                         SEQUENCE LISTING

<110>  UCL Business Ltd
       Cambridge Enterprise Limited
 
<120>  SOMATIC EXPANSION INHIBITORS

<130>  P69235WO

<150>  GB 2105484.6
<151>  2021-04-16

<150>  GB 2110949.1
<151>  2021-07-29

<160>  129   

<170>  PatentIn version 3.5

<210>  1
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Phe Val Ala Gly Val Ile Arg Arg Leu Asp Glu Thr Val Val 
1               5                   10                  15      


Asn Arg Ile Ala Ala Gly Glu Val Ile Gln Arg Pro Ala Asn Ala Ile 
            20                  25                  30          


Lys Glu Met Ile Glu Asn Cys Leu Asp Ala Lys Ser Thr Ser Ile Gln 
        35                  40                  45              


Val Ile Val Lys Glu Gly Gly Leu Lys Leu Ile Gln Ile Gln Asp Asn 
    50                  55                  60                  


Gly Thr Gly Ile Arg Lys Glu Asp Leu Asp Ile Val Cys Glu Arg Phe 
65                  70                  75                  80  


Thr Thr Ser Lys Leu Gln Ser Phe Glu Asp Leu Ala Ser Ile Ser Thr 
                85                  90                  95      


Tyr Gly Phe Arg Gly Glu Ala Leu Ala Ser Ile Ser His Val Ala His 
            100                 105                 110         


Val Thr Ile Thr Thr Lys Thr Ala Asp Gly Lys Cys Ala Tyr Arg Ala 
        115                 120                 125             


Ser Tyr Ser Asp Gly Lys Leu Lys Ala Pro Pro Lys Pro Cys Ala Gly 
    130                 135                 140                 


Asn Gln Gly Thr Gln Ile Thr Val Glu Asp Leu Phe Tyr Asn Ile Ala 
145                 150                 155                 160 


Thr Arg Arg Lys Ala Leu Lys Asn Pro Ser Glu Glu Tyr Gly Lys Ile 
                165                 170                 175     


Leu Glu Val Val Gly Arg Tyr Ser Val His Asn Ala Gly Ile Ser Phe 
            180                 185                 190         


Ser Val Lys Lys Gln Gly Glu Thr Val Ala Asp Val Arg Thr Leu Pro 
        195                 200                 205             


Asn Ala Ser Thr Val Asp Asn Ile Arg Ser Ile Phe Gly Asn Ala Val 
    210                 215                 220                 


Ser Arg Glu Leu Ile Glu Ile Gly Cys Glu Asp Lys Thr Leu Ala Phe 
225                 230                 235                 240 


Lys Met Asn Gly Tyr Ile Ser Asn Ala Asn Tyr Ser Val Lys Lys Cys 
                245                 250                 255     


Ile Phe Leu Leu Phe Ile Asn His Arg Leu Val Glu Ser Thr Ser Leu 
            260                 265                 270         


Arg Lys Ala Ile Glu Thr Val Tyr Ala Ala Tyr Leu Pro Lys Asn Thr 
        275                 280                 285             


His Pro Phe Leu Tyr Leu Ser Leu Glu Ile Ser Pro Gln Asn Val Asp 
    290                 295                 300                 


Val Asn Val His Pro Thr Lys His Glu Val His Phe Leu His Glu Glu 
305                 310                 315                 320 


Ser Ile Leu Glu Arg Val Gln Gln His Ile Glu Ser Lys Leu Leu Gly 
                325                 330                 335     


Ser Asn Ser Ser Arg Met Tyr Phe Thr Gln Thr Leu Leu Pro Gly Leu 
            340                 345                 350         


Ala Gly Pro Ser Gly Glu Met Val Lys Ser Thr Thr Ser Leu Thr Ser 
        355                 360                 365             


Ser Ser Thr Ser Gly Ser Ser Asp Lys Val Tyr Ala His Gln Met Val 
    370                 375                 380                 


Arg Thr Asp Ser Arg Glu Gln Lys Leu Asp Ala Phe Leu Gln Pro Leu 
385                 390                 395                 400 


Ser Lys Pro Leu Ser Ser Gln Pro Gln Ala Ile Val Thr Glu Asp Lys 
                405                 410                 415     


Thr Asp Ile Ser Ser Gly Arg Ala Arg Gln Gln Asp Glu Glu Met Leu 
            420                 425                 430         


Glu Leu Pro Ala Pro Ala Glu Val Ala Ala Lys Asn Gln Ser Leu Glu 
        435                 440                 445             


Gly Asp Thr Thr Lys Gly Thr Ser Glu Met Ser Glu Lys Arg Gly Pro 
    450                 455                 460                 


Thr Ser Ser Asn Pro Arg Lys Arg His Arg Glu Asp Ser Asp Val Glu 
465                 470                 475                 480 


Met Val Glu Asp Asp Ser Arg Lys Glu Met Thr Ala Ala Cys Thr Pro 
                485                 490                 495     


Arg Arg Arg Ile Ile Asn Leu Thr Ser Val Leu Ser Leu Gln Glu Glu 
            500                 505                 510         


Ile Asn Glu Gln Gly His Glu Val Leu Arg Glu Met Leu His Asn His 
        515                 520                 525             


Ser Phe Val Gly Cys Val Asn Pro Gln Trp Ala Leu Ala Gln His Gln 
    530                 535                 540                 


Thr Lys Leu Tyr Leu Leu Asn Thr Thr Lys Leu Ser Glu Glu Leu Phe 
545                 550                 555                 560 


Tyr Gln Ile Leu Ile Tyr Asp Phe Ala Asn Phe Gly Val Leu Arg Leu 
                565                 570                 575     


Ser Glu Pro Ala Pro Leu Phe Asp Leu Ala Met Leu Ala Leu Asp Ser 
            580                 585                 590         


Pro Glu Ser Gly Trp Thr Glu Glu Asp Gly Pro Lys Glu Gly Leu Ala 
        595                 600                 605             


Glu Tyr Ile Val Glu Phe Leu Lys Lys Lys Ala Glu Met Leu Ala Asp 
    610                 615                 620                 


Tyr Phe Ser Leu Glu Ile Asp Glu Glu Gly Asn Leu Ile Gly Leu Pro 
625                 630                 635                 640 


Leu Leu Ile Asp Asn Tyr Val Pro Pro Leu Glu Gly Leu Pro Ile Phe 
                645                 650                 655     


Ile Leu Arg Leu Ala Thr Glu Val Asn Trp Asp Glu Glu Lys Glu Cys 
            660                 665                 670         


Phe Glu Ser Leu Ser Lys Glu Cys Ala Met Phe Tyr Ser Ile Arg Lys 
        675                 680                 685             


Gln Tyr Ile Ser Glu Glu Ser Thr Leu Ser Gly Gln Gln Ser Glu Val 
    690                 695                 700                 


Pro Gly Ser Ile Pro Asn Ser Trp Lys Trp Thr Val Glu His Ile Val 
705                 710                 715                 720 


Tyr Lys Ala Leu Arg Ser His Ile Leu Pro Pro Lys His Phe Thr Glu 
                725                 730                 735     


Asp Gly Asn Ile Leu Gln Leu Ala Asn Leu Pro Asp Leu Tyr Lys Val 
            740                 745                 750         


Phe Glu Arg Cys 
        755     


<210>  2
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Ser Glu Gly Lys Pro Pro Asp Lys Lys Arg Pro Arg Arg Ser 
1               5                   10                  15      


Leu Ser Ile Ser Lys Asn Lys Lys Lys Ala Ser Asn Ser Ile Ile Ser 
            20                  25                  30          


Cys Phe Asn Asn Ala Pro Pro Ala Lys Leu Ala Cys Pro Val Cys Ser 
        35                  40                  45              


Lys Met Val Pro Arg Tyr Asp Leu Asn Arg His Leu Asp Glu Met Cys 
    50                  55                  60                  


Ala Asn Asn Asp Phe Val Gln Val Asp Pro Gly Gln Val Gly Leu Ile 
65                  70                  75                  80  


Asn Ser Asn Val Ser Met Val Asp Leu Thr Ser Val Thr Leu Glu Asp 
                85                  90                  95      


Val Thr Pro Lys Lys Ser Pro Pro Pro Lys Thr Asn Leu Thr Pro Gly 
            100                 105                 110         


Gln Ser Asp Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr 
        115                 120                 125             


Phe Lys Ser Asn Asp Val Val Cys Lys Asn Gln Asp Glu Leu Arg Asn 
    130                 135                 140                 


Arg Ser Val Lys Val Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser 
145                 150                 155                 160 


Arg Lys Tyr Val Lys Ala Lys Lys Ser Ile Asp Lys Asp Glu Glu Phe 
                165                 170                 175     


Ala Gly Ser Ser Pro Gln Ser Ser Lys Ser Thr Val Val Lys Ser Leu 
            180                 185                 190         


Ile Asp Asn Ser Ser Glu Ile Glu Asp Glu Asp Gln Ile Leu Glu Asn 
        195                 200                 205             


Ser Ser Gln Lys Glu Asn Val Phe Lys Cys Asp Ser Leu Lys Glu Glu 
    210                 215                 220                 


Cys Ile Pro Glu His Met Val Arg Gly Ser Lys Ile Met Glu Ala Glu 
225                 230                 235                 240 


Ser Gln Lys Ala Thr Arg Glu Cys Glu Lys Ser Ala Leu Thr Pro Gly 
                245                 250                 255     


Phe Ser Asp Asn Ala Ile Met Leu Phe Ser Pro Asp Phe Thr Leu Arg 
            260                 265                 270         


Asn Thr Leu Lys Ser Thr Ser Glu Asp Ser Leu Val Lys Gln Glu Cys 
        275                 280                 285             


Ile Lys Glu Val Val Glu Lys Arg Glu Ala Cys His Cys Glu Glu Val 
    290                 295                 300                 


Lys Met Thr Val Ala Ser Glu Ala Lys Ile Gln Leu Ser Asp Ser Glu 
305                 310                 315                 320 


Ala Lys Ser His Ser Ser Ala Asp Asp Ala Ser Ala Trp Ser Asn Ile 
                325                 330                 335     


Gln Glu Ala Pro Leu Gln Asp Asp Ser Cys Leu Asn Asn Asp Ile Pro 
            340                 345                 350         


His Ser Ile Pro Leu Glu Gln Gly Ser Ser Cys Asn Gly Pro Gly Gln 
        355                 360                 365             


Thr Thr Gly His Pro Tyr Tyr Leu Arg Ser Phe Leu Val Val Leu Lys 
    370                 375                 380                 


Thr Val Leu Glu Asn Glu Asp Asp Met Leu Leu Phe Asp Glu Gln Glu 
385                 390                 395                 400 


Lys Gly Ile Val Thr Lys Phe Tyr Gln Leu Ser Ala Thr Gly Gln Lys 
                405                 410                 415     


Leu Tyr Val Arg Leu Phe Gln Arg Lys Leu Ser Trp Ile Lys Met Thr 
            420                 425                 430         


Lys Leu Glu Tyr Glu Glu Ile Ala Leu Asp Leu Thr Pro Val Ile Glu 
        435                 440                 445             


Glu Leu Thr Asn Ala Gly Phe Leu Gln Thr Glu Ser Glu Leu Gln Glu 
    450                 455                 460                 


Leu Ser Glu Val Leu Glu Leu Leu Ser Ala Pro Glu Leu Lys Ser Leu 
465                 470                 475                 480 


Ala Lys Thr Phe His Leu Val Asn Pro Asn Gly Gln Lys Gln Gln Leu 
                485                 490                 495     


Val Asp Ala Phe Leu Lys Leu Ala Lys Gln Arg Ser Val Cys Thr Trp 
            500                 505                 510         


Gly Lys Asn Lys Pro Gly Ile Gly Ala Val Ile Leu Lys Arg Ala Lys 
        515                 520                 525             


Ala Leu Ala Gly Gln Ser Val Arg Ile Cys Lys Gly Pro Arg Ala Val 
    530                 535                 540                 


Phe Ser Arg Ile Leu Leu Leu Phe Ser Leu Thr Asp Ser Met Glu Asp 
545                 550                 555                 560 


Glu Asp Ala Ala Cys Gly Gly Gln Gly Gln Leu Ser Thr Val Leu Leu 
                565                 570                 575     


Val Asn Leu Gly Arg Met Glu Phe Pro Ser Tyr Thr Ile Asn Arg Lys 
            580                 585                 590         


Thr His Ile Phe Gln Asp Arg Asp Asp Leu Ile Arg Tyr Ala Ala Ala 
        595                 600                 605             


Thr His Met Leu Ser Asp Ile Ser Ser Ala Met Ala Asn Gly Asn Trp 
    610                 615                 620                 


Glu Glu Ala Lys Glu Leu Ala Gln Cys Ala Lys Arg Asp Trp Asn Arg 
625                 630                 635                 640 


Leu Lys Asn His Pro Ser Leu Arg Cys His Glu Asp Leu Pro Leu Phe 
                645                 650                 655     


Leu Arg Cys Phe Thr Val Gly Trp Ile Tyr Thr Arg Ile Leu Ser Arg 
            660                 665                 670         


Phe Val Glu Ile Leu Gln Arg Leu His Met Tyr Glu Glu Ala Val Arg 
        675                 680                 685             


Glu Leu Glu Ser Leu Leu Ser Gln Arg Ile Tyr Cys Pro Asp Ser Arg 
    690                 695                 700                 


Gly Arg Trp Trp Asp Arg Leu Ala Leu Asn Leu His Gln His Leu Lys 
705                 710                 715                 720 


Arg Leu Glu Pro Thr Ile Lys Cys Ile Thr Glu Gly Leu Ala Asp Pro 
                725                 730                 735     


Glu Val Arg Thr Gly His Arg Leu Ser Leu Tyr Gln Arg Ala Val Arg 
            740                 745                 750         


Leu Arg Glu Ser Pro Ser Cys Lys Lys Phe Lys His Leu Phe Gln Gln 
        755                 760                 765             


Leu Pro Glu Met Ala Val Gln Asp Val Lys His Val Thr Ile Thr Gly 
    770                 775                 780                 


Arg Leu Cys Pro Gln Arg Gly Met Cys Lys Ser Val Phe Val Met Glu 
785                 790                 795                 800 


Ala Gly Glu Ala Ala Asp Pro Thr Thr Val Leu Cys Ser Val Glu Glu 
                805                 810                 815     


Leu Ala Leu Ala His Tyr Arg Arg Ser Gly Phe Asp Gln Gly Ile His 
            820                 825                 830         


Gly Glu Gly Ser Thr Phe Ser Thr Leu Tyr Gly Leu Leu Leu Trp Asp 
        835                 840                 845             


Ile Ile Phe Met Asp Gly Ile Pro Asp Val Phe Arg Asn Ala Cys Gln 
    850                 855                 860                 


Ala Phe Pro Leu Asp Leu Cys Thr Asp Ser Phe Phe Thr Ser Arg Arg 
865                 870                 875                 880 


Pro Ala Leu Glu Ala Arg Leu Gln Leu Ile His Asp Ala Pro Glu Glu 
                885                 890                 895     


Ser Leu Arg Ala Trp Val Ala Ala Thr Trp His Glu Gln Glu Gly Arg 
            900                 905                 910         


Val Ala Ser Leu Val Ser Trp Asp Arg Phe Thr Ser Leu Gln Gln Ala 
        915                 920                 925             


Gln Asp Leu Val Ser Cys Leu Gly Gly Pro Val Leu Ser Gly Val Cys 
    930                 935                 940                 


Arg His Leu Ala Ala Asp Phe Arg His Cys Arg Gly Gly Leu Pro Asp 
945                 950                 955                 960 


Leu Val Val Trp Asn Ser Gln Ser Arg His Phe Lys Leu Val Glu Val 
                965                 970                 975     


Lys Gly Pro Asn Asp Arg Leu Ser His Lys Gln Met Ile Trp Leu Ala 
            980                 985                 990         


Glu Leu Gln Lys Leu Gly Ala Glu  Val Glu Val Cys His  Val Val Ala 
        995                 1000                 1005             


Val Gly  Ala Lys Ser Gln Ser  Leu Ser 
    1010                 1015         


<210>  3
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Pro Tyr Phe 
1               


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Ala Ser Lys Leu 
1               5   


<210>  5
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  5

Gln Lys Ile Ser Pro Tyr Phe 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Pro Tyr Phe Lys Ser Asn 
1               5           


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Lys Ile Ser Pro Tyr Phe Lys Ser Asn 
1               5                   10  


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Pro Tyr Phe Lys 
1               5   


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Ile Gly Phe Ser His Leu Gln Gln Arg 
1               5                   10  


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Thr Leu Glu Leu Leu Val Cys Arg 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Gln Glu Phe Leu Gln Thr Leu Arg 
1               5                   


<210>  12
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Asn Leu Thr Pro Gly Gln Ser Asp Ser Ala Lys Arg 
1               5                   10              


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Leu Asp Glu Thr Val Val Asn Arg 
1               5                   


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Pro Ser Glu Glu Tyr Gly Lys 
1               5               


<210>  15
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Gly Leu Pro Asp Leu Val Val Trp Asn Ser Gln Ser Arg 
1               5                   10                  


<210>  16
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  16

His Val Thr Ile Thr Gly Arg Leu Cys Pro Gln Arg 
1               5                   10          


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg His Pro Ser Tyr Pro Lys 
1               5           


<210>  18
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Ser Val His Asn Ala Gly Ile Ser Phe Ser Val Lys Lys Gln Gly 
1               5                   10                  15      


Glu Thr Val Ala Asp Val Arg 
            20              


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Asn Ser Glu Cys Asp Pro Thr Pro Ser His Arg 
1               5                   10      


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Gly Glu Thr Val Ala Asp Val Arg 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Ser Leu Tyr Gln Arg Ala Val Arg 
1               5                   


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Ala Lys Ala Leu Ala Gly Gln Ser Val Arg Ile Cys Lys 
1               5                   10                  


<210>  23
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  23

Tyr Glu Lys Thr Ile Ser Glu Ala Trp Ile Lys 
1               5                   10      


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Leu Ser Gln Gln Ala Asp Val Arg 
1               5                   


<210>  25
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Asn Leu Thr Pro Gly Gln Ser Asp Ser Ala Lys Arg 
1               5                   10              


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Leu Tyr Trp Asn Met Ala Val Arg 
1               5                   


<210>  27
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Gly Thr Arg Leu Met Phe Asp His Asn Gly Lys Ile Ile Gln Lys 
1               5                   10                  15      


<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Leu Ala Gly Gln Ser Val Arg Ile Cys Lys Gly Pro Arg 
1               5                   10                  


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Leu Gln Glu Phe Leu Gln Thr Leu Arg 
1               5                   


<210>  30
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  30

Thr Gly Glu Glu Lys Lys Asp Val Ser Ile Ser Arg 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Phe Lys Asp Leu Gln Leu Leu Gln Gly Ser Lys 
1               5                   10          


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Leu Lys Asn Pro Ser Glu Glu Tyr Gly Lys 
1               5                   10      


<210>  33
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Gln Ala Ser Gln Val Lys Leu Lys Ser Lys Gly Arg 
1               5                   10              


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Lys Gln Gly Glu Thr Val Ala Asp Val Arg 
1               5                   10  


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Leu Lys Asn Pro Ser Glu Glu Tyr Gly Lys 
1               5                   10      


<210>  36
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Leu Ala Gly Gln Ser Val Arg Ile Cys Lys Gly Pro Arg 
1               5                   10                  


<210>  37
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  37

Leu Leu Met Val Ile Leu Glu Lys Ser Thr Ala Ser Ala Gln Asn Lys 
1               5                   10                  15      


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Asn Asp Val Val Cys Lys 
1               5           


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  39

Thr Leu Pro Asn Ala Ser Thr Val Asp Asn Ile Arg 
1               5                   10          


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Val Lys Gln Lys Ile Ser Pro Tyr Phe Lys 
1               5                   10      


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Lys Asp Val Ser Ile Ser Arg Leu Arg 
1               5                   


<210>  42
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Leu Met Asn Leu Leu Phe Ser Leu His Val Ser Tyr Lys 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Val Met Ile Gly Thr Ala Leu Asn Thr Ser Glu Met Lys 
1               5                   10                  


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Ile Lys Lys Glu Tyr Ala Lys 
1               5               


<210>  45
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Ser Lys Val Asn Leu Met Gln His Met Lys Leu Ser Thr Ser Arg 
1               5                   10                  15      


<210>  46
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  46

Trp Thr Val Glu His Ile Val Tyr Lys Ala Leu Arg 
1               5                   10          


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Phe Gln Thr Leu Arg Arg His Pro Ser Tyr Pro Lys 
1               5                   10              


<210>  48
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Ala Ser Asn Ser Ile Ile Ser Cys Phe Asn Asn Ala Pro Pro Ala 
1               5                   10                  15      


Lys 
    


<210>  49
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  49

Leu Leu Tyr Trp Asn Met Ala Val Arg 
1               5                   


<210>  50
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  50

Thr Ser Val Val Lys Ser Phe Lys 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Lys Thr His Ile Phe Gln Asp Arg 
1               5               


<210>  52
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  52

Lys Ser Ala Val Ala Gly Phe Leu Leu Leu Leu Lys 
1               5                   10          


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Lys Thr His Ile Phe Gln Asp Arg 
1               5               


<210>  54
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Glu Ser Pro Ser Leu Thr Gln Glu Arg 
1               5                   10  


<210>  55
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  55

Phe Val Glu Ile Leu Gln Arg Leu His Met Tyr Glu Glu Ala Val Arg 
1               5                   10                  15      


<210>  56
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Met Phe Ala Ser Arg Ala Cys Arg 
1               5                   


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Leu Ser Trp Ile Lys Met Thr Lys 
1               5               


<210>  58
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  58

Leu Glu Ser Met Ser Ala Lys 
1               5           


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Met Phe Ala Ser Arg Ala Cys Arg Lys 
1               5                   10  


<210>  60
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  60

Thr Arg Lys Gln Pro Leu Ser Lys 
1               5               


<210>  61
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  61

Thr Pro Tyr Pro Arg Pro Arg 
1               5           


<210>  62
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Val Ser Lys Arg Arg 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  63

Lys Ser Pro Pro Pro Lys 
1               5       


<210>  64
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  64

Arg Ser Pro Leu Gly Gln Lys 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  65

Leu Asp Tyr Glu Leu Gly Arg 
1               5           


<210>  66
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  66

Lys Ser Pro Pro Pro Lys 
1               5       


<210>  67
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  67

Lys Asp Val Ser Ile Ser Arg 
1               5           


<210>  68
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  68

Thr Gly Glu Glu Lys Lys 
1               5       


<210>  69
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  69

Leu Glu Ser Met Ser Ala Lys 
1               5           


<210>  70
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Pro Leu Ser Lys Lys 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  71

Ile Ala Ser Leu Ala Arg 
1               5       


<210>  72
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  72

Lys Gln Lys Thr Asp Gly Ser Lys 
1               5               


<210>  73
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  73

Val Ser Met Ser Met Arg 
1               5       


<210>  74
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  74

Val Pro Phe Leu Lys Asn Lys 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Tyr Ser Asp Gly Lys 
1               5           


<210>  76
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  76

Thr Ser Val Val Lys Ser Phe Lys 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  77

Leu Arg Glu Ala Phe Ser Leu Arg 
1               5               


<210>  78
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Leu Ile Asn Thr Leu Cys Ser Gly Arg 
1               5                   10  


<210>  79
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  79

Asn His Pro Ser Leu Arg 
1               5       


<210>  80
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Val Ser Lys Arg Arg 
1               5       


<210>  81
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  81

Lys Tyr Val Lys Ala Lys Lys 
1               5           


<210>  82
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  82

Leu Leu Gly Ser Asn Ser Ser Arg 
1               5               


<210>  83
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Thr Ser Glu Met Ser Glu Lys Arg 
1               5                   


<210>  84
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  84

Lys Glu Asn Leu Ala Tyr Gly Lys 
1               5               


<210>  85
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Arg Glu Ser Pro Ser Cys Lys Lys 
1               5                   


<210>  86
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  86

Gly Thr Ser Glu Met Ser Glu Lys Arg 
1               5                   


<210>  87
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  87

Leu Phe Gln Thr Leu Arg Arg 
1               5           


<210>  88
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  88

Leu Glu Pro Thr Ile Lys 
1               5       


<210>  89
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  89

Thr Asp Ile Ser Ser Gly Arg 
1               5           


<210>  90
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  90

Val Ser Met Ser Met Arg 
1               5       


<210>  91
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Pro Leu Gly Gln Lys 
1               5       


<210>  92
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  92

Asn Pro Ser Glu Glu Tyr Gly Lys 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  93

Lys Thr His Ile Phe Gln Asp Arg 
1               5               


<210>  94
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  94

Val Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser Arg 
1               5                   10              


<210>  95
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  95

Arg Ser Leu Ser Ile Ser Lys 
1               5           


<210>  96
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Tyr Val Arg Leu Phe Gln Arg 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  97

Leu Ser Asp Ile Leu Asn Glu Lys 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  98

Glu Gly Ser Leu Val Asn Gly Lys 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Thr Ser Glu Met Ser Glu Lys 
1               5               


<210>  100
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  100

Thr Asp Ile Ser Ser Gly Arg 
1               5           


<210>  101
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  101

Lys Leu Phe Gln Thr Leu Arg 
1               5           


<210>  102
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Val Ser Lys Arg Arg 
1               5       


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Leu Pro Glu Tyr Phe Phe Glu Asn Lys 
1               5                   


<210>  104
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Val Ser Lys Arg Arg 
1               5       


<210>  105
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  105

Lys Thr His Ile Phe Gln Asp Arg 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  106

Asn Ile Lys Lys Glu Tyr Ala Lys 
1               5               


<210>  107
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Pro Ala Lys Lys Lys 
1               5       


<210>  108
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  108

Ala Thr Arg Glu Cys Glu Lys 
1               5           


<210>  109
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  109

Asn Met Glu Lys Leu Val Lys 
1               5           


<210>  110
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  110

Ser Leu Asn Tyr Thr Gly Glu Lys 
1               5               


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer targeting region proximal to CAG repeat in Homo sapiens 
       HTT gene

<400>  111
ccgctcaggt tctgctttta                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer targeting region proximal to CAG repeat in Homo sapiens 
       HTT gene

<400>  112
gccttcatca gcttttccag                                                   20


<210>  113
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer targeting region proximal to CAG repeat in Homo sapiens 
       HTT gene

<400>  113
ccagagcccc attcattg                                                     18


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer targeting region proximal to CAG repeat in Homo sapiens 
       HTT gene

<400>  114
gccttcatca gcttttccag                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer targeting region proximal to CAG repeat in Homo sapiens 
       HTT gene

<400>  115
tgcctttcga agttgatgca                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer targeting region proximal to CAG repeat in Homo sapiens 
       HTT gene

<400>  116
tgccaccacg aatttcacaa                                                   20


<210>  117
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplifying Homo sapiens HTT locus

<400>  117
aaggccttcg agtccctcaa gtcctt                                            26


<210>  118
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer for amplifying Homo sapiens HTT locus

<400>  118
cggctgaggc agcagcggct gt                                                22


<210>  119
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  119

Glu Val Lys Gln Lys Ile Ser Pro Tyr Phe Lys Ser Asn Asp Val Val 
1               5                   10                  15      


Cys Lys 
        


<210>  120
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  120

Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr Phe Lys Ser 
1               5                   10                  15      


Asn Asp Val Val Cys Lys Asn Gln Asp Glu Leu Arg 
            20                  25              


<210>  121
<211>  26
<212>  PRT
<213>  Mus musculus

<400>  121

Ser Lys Leu Gly Ile Gln Gln Gln Thr Ser Pro Tyr Phe Lys Asp Ala 
1               5                   10                  15      


Leu Val Ser Lys Asp Gln Asn Glu Leu Pro 
            20                  25      


<210>  122
<211>  28
<212>  PRT
<213>  Gallus gallus

<400>  122

Lys Ala Glu Arg Arg Ala Val Gln Gln Val Ser Pro Tyr Phe Ser Asn 
1               5                   10                  15      


Lys Gly Ser Val Ser Asp Val Cys Thr Glu Pro Leu 
            20                  25              


<210>  123
<211>  28
<212>  PRT
<213>  Anolis carolinensis

<400>  123

Gln Ser Lys Ser Val Ala Gly Gly Glu Thr Ser Pro Tyr Phe Lys Lys 
1               5                   10                  15      


His Gly Gly Leu Ala Leu Asp Asp Gly Gln Pro Lys 
            20                  25              


<210>  124
<211>  28
<212>  PRT
<213>  Xenopus leavis

<400>  124

Ser Pro Pro Lys Pro Asn Glu Lys Gln Thr Ser Ser Tyr Phe Asn Lys 
1               5                   10                  15      


Val Asp Pro Val Lys Glu Leu His Asn Glu Lys Glu 
            20                  25              


<210>  125
<211>  28
<212>  PRT
<213>  Danio rerio

<400>  125

Lys Ser Pro Gly Asp Lys Asp Ala Asp Thr Ser Pro Phe Phe Lys Lys 
1               5                   10                  15      


Asn Cys Ala Val Arg Arg Asp Ser Ser Glu Thr Asp 
            20                  25              


<210>  126
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  126

Ser Asp Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr Phe 
1               5                   10                  15      


Lys Ser Asn Asp Val Val Cys Lys 
            20                  


<210>  127
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  127

Ala Pro Tyr Phe 
1               

<210>  128
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  128

Ser Pro Ala Phe 
1               


<210>  129
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  129

Ser Pro Tyr Ala 
1               


