                         SEQUENCE LISTING

<110>  UCL Business Ltd
 
<120>  COMPOSITION

<130>  P6137GBWO

<150>  GB2105455.6
<151>  2021-04-16

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 1 (sense) custom spacer

<400>  1
cttgttcacc ctcagcgagt actgtgagag                                        30


<210>  2
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 1 (sense) Pre-gRNA + spacer

<400>  2
caagtaaacc cctaccaact ggtcggggtt tgaaaccttg ttcaccctca gcgagtactg       60

tgagag                                                                  66


<210>  3
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 1 (sense) mature gRNA + spacer

<400>  3
aacccctacc aactggtcgg ggtttgaaac cttgttcacc ctcagcgagt ac               52


<210>  4
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 2 (sense) custom spacer

<400>  4
caggtctttt cttgttcacc ctcagcgagt                                        30


<210>  5
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 2 (sense) pre-gRNA + spacer

<400>  5
caagtaaacc cctaccaact ggtcggggtt tgaaaccagg tcttttcttg ttcaccctca       60

gcgagt                                                                  66


<210>  6
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 2 (sense) mature gRNA + spacer

<400>  6
aacccctacc aactggtcgg ggtttgaaac caggtctttt cttgttcacc ct               52


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 3 (sense) custom spacer

<400>  7
taatctttat caggtctttt cttgttcacc                                        30


<210>  8
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 3 (sense) pre-gRNA + spacer

<400>  8
caagtaaacc cctaccaact ggtcggggtt tgaaactaat ctttatcagg tcttttcttg       60

ttcacc                                                                  66


<210>  9
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 3 (sense) mature gRNA + spacer

<400>  9
aacccctacc aactggtcgg ggtttgaaac taatctttat caggtctttt ct               52


<210>  10
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 4 (sense) custom spacer

<400>  10
ttcttctggt taatctttat caggtctttt                                        30


<210>  11
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 4 (sense) pre-gRNA + spacer

<400>  11
caagtaaacc cctaccaact ggtcggggtt tgaaacttct tctggttaat ctttatcagg       60

tctttt                                                                  66


<210>  12
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 4 (sense) mature gRNA + spacer

<400>  12
aacccctacc aactggtcgg ggtttgaaac ttcttctggt taatctttat ca               52


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 5 (sense) custom spacer

<400>  13
cctccttgtt ttcttctggt taatctttat                                        30


<210>  14
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 5 (sense) pre-gRNA + spacer

<400>  14
caagtaaacc cctaccaact ggtcggggtt tgaaaccctc cttgttttct tctggttaat       60

ctttat                                                                  66


<210>  15
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 5 (sense) mature gRNA + spacer

<400>  15
aacccctacc aactggtcgg ggtttgaaac cctccttgtt ttcttctggt ta               52


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 6 (sense) custom spacer

<400>  16
cggttgtttc cctccttgtt ttcttctggt                                        30


<210>  17
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 6 (sense) pre-gRNA + spacer

<400>  17
caagtaaacc cctaccaact ggtcggggtt tgaaaccggt tgtttccctc cttgttttct       60

tctggt                                                                  66


<210>  18
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 6 (sense) mature gRNA + spacer

<400>  18
aacccctacc aactggtcgg ggtttgaaac cggttgtttc cctccttgtt tt               52


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 7 (sense) custom spacer

<400>  19
ctacaggctg cggttgtttc cctccttgtt                                        30


<210>  20
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 7 (sense) pre-gRNA + spacer

<400>  20
caagtaaacc cctaccaact ggtcggggtt tgaaacctac aggctgcggt tgtttccctc       60

cttgtt                                                                  66


<210>  21
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 7 (sense) mature gRNA + spacer

<400>  21
aacccctacc aactggtcgg ggtttgaaac ctacaggctg cggttgtttc cc               52


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 8 (sense) custom spacer

<400>  22
ccagagcttg ctacaggctg cggttgtttc                                        30


<210>  23
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 8 (sense) pre-gRNA + spacer

<400>  23
caagtaaacc cctaccaact ggtcggggtt tgaaacccag agcttgctac aggctgcggt       60

tgtttc                                                                  66


<210>  24
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 8 (sense) mature gRNA + spacer

<400>  24
aacccctacc aactggtcgg ggtttgaaac ccagagcttg ctacaggctg cg               52


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 9 (sense) custom spacer

<400>  25
ctcctgagtt ccagagcttg ctacaggctg                                        30


<210>  26
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 9 (sense) pre-gRNA + spacer

<400>  26
caagtaaacc cctaccaact ggtcggggtt tgaaacctcc tgagttccag agcttgctac       60

aggctg                                                                  66


<210>  27
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 9 (sense) mature gRNA + spacer

<400>  27
aacccctacc aactggtcgg ggtttgaaac ctcctgagtt ccagagcttg ct               52


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 10 (sense) custom spacer

<400>  28
tagcgcgcga ctcctgagtt ccagagcttg                                        30


<210>  29
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 10 (sense) pre-gRNA + spacer

<400>  29
caagtaaacc cctaccaact ggtcggggtt tgaaactagc gcgcgactcc tgagttccag       60

agcttg                                                                  66


<210>  30
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 10 (sense) mature gRNA + spacer

<400>  30
aacccctacc aactggtcgg ggtttgaaac tagcgcgcga ctcctgagtt cc               52


<210>  31
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 11 (antisense) custom spacer

<400>  31
cgcaggcggt ggcgagtggg tgagtgagga                                        30


<210>  32
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 11 (antisense) pre-gRNA + spacer

<400>  32
caagtaaacc cctaccaact ggtcggggtt tgaaaccgca ggcggtggcg agtgggtgag       60

tgagga                                                                  66


<210>  33
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 11 (antisense) mature gRNA + spacer

<400>  33
aacccctacc aactggtcgg ggtttgaaac cgcaggcggt ggcgagtggg tg               52


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 12 (antisense) custom spacer

<400>  34
tgcgcccgcg gcggcggagg cgcaggcggt                                        30


<210>  35
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 12 (antisense) pre-gRNA + spacer

<400>  35
caagtaaacc cctaccaact ggtcggggtt tgaaactgcg cccgcggcgg cggaggcgca       60

ggcggt                                                                  66


<210>  36
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 12 (antisense) mature gRNA + spacer

<400>  36
aacccctacc aactggtcgg ggtttgaaac tgcgcccgcg gcggcggagg cg               52


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 13 (antisense) custom spacer

<400>  37
ttaactttcc ctctcatttc tctgaccgaa                                        30


<210>  38
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 13 (antisense) pre-gRNA + spacer

<400>  38
caagtaaacc cctaccaact ggtcggggtt tgaaacttaa ctttccctct catttctctg       60

accgaa                                                                  66


<210>  39
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 13 (antisense) mature gRNA + spacer

<400>  39
aacccctacc aactggtcgg ggtttgaaac ttaactttcc ctctcatttc tc               52


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 14 (antisense) custom spacer

<400>  40
ttcggctgcc gggaagaggc gcgggtagaa                                        30


<210>  41
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 14 (antisense) pre-gRNA + spacer

<400>  41
caagtaaacc cctaccaact ggtcggggtt tgaaacttcg gctgccggga agaggcgcgg       60

gtagaa                                                                  66


<210>  42
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 14 (antisense) mature gRNA + spacer

<400>  42
aacccctacc aactggtcgg ggtttgaaac ttcggctgcc gggaagaggc gc               52


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 17 (antisense) custom spacer

<400>  43
tccctctcat ttctctgacc gaagctgggt                                        30


<210>  44
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 17 (antisense) pre-gRNA + spacer

<400>  44
caagtaaacc cctaccaact ggtcggggtt tgaaactccc tctcatttct ctgaccgaag       60

ctgggt                                                                  66


<210>  45
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 17 (antisense) mature gRNA + spacer

<400>  45
aacccctacc aactggtcgg ggtttgaaac tccctctcat ttctctgacc gaa              53


<210>  46
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pre-gRNA direct repeat sequence

<400>  46
caagtaaacc cctaccaact ggtcggggtt tgaaac                                 36


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mature gRNA direct repeat sequence

<400>  47
aacccctacc aactggtcgg ggtttgaaac                                        30


<210>  48
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U6 gRNA PacI PCR Cloning Forward Primer

<400>  48
gcattaatta attacggttc ctggcctttt g                                      31


<210>  49
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U6 gRNA PacI PCR Cloning Reverse Primer

<400>  49
gcattaatta acgtaaggag aaaataccgc atca                                   34


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS55RNL Seq Forward Primer

<400>  50
ttcctagcaa ccccgacttg                                                   20


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS55RNL Seq Reverse Primer

<400>  51
ttggatcgga gttacggaca cc                                                22


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ef1a Seq Forward Primer

<400>  52
tcaagcctca gacagtggtt c                                                 21


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  U6 Seq Forward Primer

<400>  53
gactatcata tgcttaccgt                                                   20


<210>  54
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA-FISH Locked Nucleic Acid (LNA) Probe Sense

<400>  54
ccccggcccc ggcccc                                                       16


<210>  55
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA-FISH Locked Nucleic Acid (LNA) Probe Antisense

<400>  55
ggggccgggg ccgggg                                                       16


<210>  56
<211>  27322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of C9orf72 gene

<400>  56
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg gtgtgtcagc cgtccctgct gcccggttgc ttctcttttg      120

ggggcggggt ctagcaagag caggtgtggg tttaggaggt gtgtgttttt gtttttccca      180

ccctctctcc ccactacttg ctctcacagt actcgctgag ggtgaacaag aaaagacctg      240

ataaagatta accagaagaa aacaaggagg gaaacaaccg cagcctgtag caagctctgg      300

aactcaggag tcgcgcgcta ggggccgggg ccggggccgg ggcgtggtcg gggcgggccc      360

gggggcgggc ccggggcggg gctgcggttg cggtgcctgc gcccgcggcg gcggaggcgc      420

aggcggtggc gagtgggtga gtgaggaggc ggcatcctgg cgggtggctg tttggggttc      480

ggctgccggg aagaggcgcg ggtagaagcg ggggctctcc tcagagctcg acgcattttt      540

actttccctc tcatttctct gaccgaagct gggtgtcggg ctttcgcctc tagcgactgg      600

tggaattgcc tgcatccggg ccccgggctt cccggcggcg gcggcggcgg cggcggcgca      660

gggacaaggg atggggatct ggcctcttcc ttgctttccc gccctcagta cccgagctgt      720

ctccttcccg gggacccgct gggagcgctg ccgctgcggg ctcgagaaaa gggagcctcg      780

ggtactgaga ggcctcgcct gggggaaggc cggagggtgg gcggcgcgcg gcttctgcgg      840

accaagtcgg ggttcgctag gaacccgaga cggtccctgc cggcgaggag atcatgcggg      900

atgagatggg ggtgtggaga cgcctgcaca atttcagccc aagcttctag agagtggtga      960

tgacttgcat atgagggcag caatgcaagt cggtgtgctc cccattctgt gggacatgac     1020

ctggttgctt cacagctccg agatgacaca gacttgctta aaggaagtga ctattgtgac     1080

ttgggcatca cttgactgat ggtaatcagt tgtctaaaga agtgcacaga ttacatgtcc     1140

gtgtgctcat tgggtctatc tggccgcgtt gaacaccacc aggctttgta ttcagaaaca     1200

ggagggaggt cctgcacttt cccaggaggg gtggcccttt cagatgcaat cgagattgtt     1260

aggctctggg agagtagttg cctggttgtg gcagttggta aatttctatt caaacagttg     1320

ccatgcacca gttgttcaca acaagggtac gtaatctgtc tggcattact tctacttttg     1380

tacaaaggat caaaaaaaaa aaagatactg ttaagatatg atttttctca gactttggga     1440

aacttttaac ataatctgtg aatatcacag aaacaagact atcatatagg ggatattaat     1500

aacctggagt cagaatactt gaaatacggt gtcatttgac acgggcattg ttgtcaccac     1560

ctctgccaag gcctgccact ttaggaaaac cctgaatcag ttggaaactg ctacatgctg     1620

atagtacatc tgaaacaaga acgagagtaa ttaccacatt ccagattgtt cactaagcca     1680

gcatttacct gctccaggaa aaaattacaa gcaccttatg aagttgataa aatattttgt     1740

ttggctatgt tggcactcca caatttgctt tcagagaaac aaagtaaacc aaggaggact     1800

tctgtttttc aagtctgccc tcgggttcta ttctacgtta attagatagt tcccaggagg     1860

actaggttag cctacctatt gtctgagaaa cttggaactg tgagaaatgg ccagatagtg     1920

atatgaactt caccttccag tcttccctga tgttgaagat tgagaaagtg ttgtgaactt     1980

tctggtactg taaacagttc actgtccttg aagtggtcct gggcagctcc tgttgtggaa     2040

agtggacggt ttaggatcct gcttctcttt gggctgggag aaaataaaca gcatggttac     2100

aagtattgag agccaggttg gagaaggtgg cttacacctg taatgccaga gctttgggag     2160

gcggaggcaa gaggatcact tgaagccagg agttcaagct caacctgggc aacgtagacc     2220

ctgtctctac aaaaaattaa aaacttagcc gggcgtggtg atgtgcacct gtagtcctag     2280

ctacttggga ggctgaggca ggagggtcat ttgagcccaa gagtttgaag ttaccgagag     2340

ctatgatcct gccagtgcat tccagcctgg atgacaaaac gagaccctgt ctctaaaaaa     2400

caagaagtga gggctttatg attgtagaat tttcactaca atagcagtgg accaaccacc     2460

tttctaaata ccaatcaggg aagagatggt tgatttttta acagacgttt aaagaaaaag     2520

caaaacctca aacttagcac tctactaaca gttttagcag atgttaatta atgtaatcat     2580

gtctgcatgt atgggattat ttccagaaag tgtattggga aacctctcat gaaccctgtg     2640

agcaagccac cgtctcactc aatttgaatc ttggcttccc tcaaaagact ggctaatgtt     2700

tggtaactct ctggagtaga cagcactaca tgtacgtaag ataggtacat aaacaactat     2760

tggttttgag ctgatttttt tcagctgcat ttgcatgtat ggatttttct caccaaagac     2820

gatgacttca agtattagta aaataattgt acagctctcc tgattatact tctctgtgac     2880

atttcatttc ccaggctatt tcttttggta ggatttaaaa ctaagcaatt cagtatgatc     2940

tttgtccttc attttctttc ttattctttt tgtttgtttg tttgtttgtt tttttcttga     3000

ggcagagtct ctctctgtcg cccaggctgg agtgcagtgg cgccatctca gctcattgca     3060

acctctgcca cctccgggtt caagagattc tcctgcctca gcctcccgag tagctgggat     3120

tacaggtgtc caccaccaca cccggctaat tttttgtatt tttagtagag gtggggtttc     3180

accatgttgg ccaggctggt cttgagctcc tgacctcagg tgatccacct gcctcggcct     3240

accaaagagc tgggataaca ggtgtgaccc accatgcccg gcccattttt tttttcttat     3300

tctgttagga gtgagagtgt aactagcagt ataatagttc aattttcaca acgtggtaaa     3360

agtttcccta taattcaatc agattttgct ccagggttca gttctgtttt aggaaatact     3420

tttattttca gtttaatgat gaaatattag agttgtaata ttgcctttat gattatccac     3480

ctttttaacc taaaagaatg aaagaaaaat atgtttgcaa tataatttta tggttgtatg     3540

ttaacttaat tcattatgtt ggcctccagt ttgctgttgt tagttatgac agcagtagtg     3600

tcattaccat ttcaattcag attacattcc tatatttgat cattgtaaac tgactgctta     3660

cattgtatta aaaacagtgg atattttaaa gaagctgtac ggcttatatc tagtgctgtc     3720

tcttaagact attaaattga tacaacatat ttaaaagtaa atattaccta aatgaatttt     3780

tgaaattaca aatacacgtg ttaaaactgt cgttgtgttc aaccatttct gtacatactt     3840

agagttaact gttttgccag gctctgtatg cctactcata atatgataaa agcactcatc     3900

taatgctctg taaatagaag tcagtgcttt ccatcagact gaactctctt gacaagatgt     3960

ggatgaaatt ctttaagtaa aattgtttac tttgtcatac atttacagat caaatgttag     4020

ctcccaaagc aatcatatgg caaagatagg tatatcatag tttgcctatt agctgctttg     4080

tattgctatt attataaata gacttcacag ttttagactt gcttaggtga aattgcaatt     4140

ctttttactt tcagtcttag ataacaagtc ttcaattata gtacaatcac acattgctta     4200

ggaatgcatc attaggcgat tttgtcatta tgcaaacatc atagagtgta cttacacaaa     4260

cctagatagt atagccttta tgtacctagg ccgtatggta tagtctgttg ctcctaggcc     4320

acaaacctgt acaactgtta ctgtactgaa tactatagac agttgtaaca cagtggtaaa     4380

tatttatcta aatatatgca aacagagaaa aggtacagta aaagtatggt ataaaagata     4440

atggtatacc tgtgtaggcc acttaccacg aatggagctt gcaggactag aagttgctct     4500

gggtgagtca gtgagtgagt ggtgaattaa tgtgaaggcc tagaacactg tacaccactg     4560

tagactataa acacagtacg ctgaagctac accaaattta tcttaacagt ttttcttcaa     4620

taaaaaatta taacttttta actttgtaaa ctttttaatt ttttaacttt taaaatactt     4680

agcttgaaac acaaatacat tgtatagcta tacaaaaata ttttttcttt gtatccttat     4740

tctagaagct tttttctatt ttctatttta aatttttttt tttacttgtt agtcgttttt     4800

gttaaaaact aaaacacaca cactttcacc taggcataga caggattagg atcatcagta     4860

tcactccctt ccacctcact gccttccacc tccacatctt gtcccactgg aaggttttta     4920

ggggcaataa cacacatgta gctgtcacct atgataacag tgctttctgt tgaatacctc     4980

ctgaaggact tgcctgaggc tgttttacat ttaacttaaa aaaaaaaaaa gtagaaggag     5040

tgcactctaa aataacaata aaaggcatag tatagtgaat acataaacca gcaatgtagt     5100

agtttattat caagtgttgt acactgtaat aattgtatgt gctatacttt aaataacttg     5160

caaaatagta ctaagacctt atgatggtta cagtgtcact aaggcaatag catattttca     5220

ggtccattgt aatctaatgg gactaccatc atatatgcag tctaccattg actgaaacgt     5280

tacatggcac ataactgtat ttgcaagaat gatttgtttt acattaatat cacataggat     5340

gtaccttttt agagtggtat gtttatgtgg attaagatgt acaagttgag caaggggacc     5400

aagagccctg ggttctgtct tggatgtgag cgtttatgtt cttctcctca tgtctgtttt     5460

ctcattaaat tcaaaggctt gaacgggccc tatttagccc ttctgttttc tacgtgttct     5520

aaataactaa agcttttaaa ttctagccat ttagtgtaga actctctttg cagtgatgaa     5580

atgctgtatt ggtttcttgg ctagcatatt aaatattttt atctttgtct tgatacttca     5640

atgtcgtttt aaacatcagg atcgggcttc agtattctca taaccagaga gttcactgag     5700

gatacaggac tgtttgccca ttttttgtta tggctccaga cttgtggtat ttccatgtct     5760

tttttttttt tttttttttt gaccttttag cggctttaaa gtatttctgt tgttaggtgt     5820

tgtattactt ttctaagatt acttaacaaa gcaccacaaa ctgagtggct ttaaacaaca     5880

gcaatttatt ctctcacaat tctagaagct agaagtccga aatcaaagtg ttgacagggg     5940

catgatcttc aagagagaag actctttcct tgcctcttcc tggcttctgg tggttaccag     6000

caatcctgag tgttcctttc ttgccttgta gtttcaacaa tccagtatct gccttttgtc     6060

ttcacatggc tgtctaccat ttgtctctgt gtctccaaat ctctctcctt ataaacacag     6120

cagttattgg attaggcccc actctaatcc agtatgaccc cattttaaca tgattacact     6180

tatttctaga taaggtcaca ttcacgtaca ccaagggtta ggaattgaac atatcttttt     6240

gggggacaca attcaaccca caagtgtcag tctctagctg agcctttccc ttcctgtttt     6300

tctccttttt agttgctatg ggttaggggc caaatctcca gtcatactag aattgcacat     6360

ggactggata tttgggaata ctgcgggtct attctatgag ctttagtatg taacatttaa     6420

tatcagtgta aagaagccct tttttaagtt atttctttga atttctaaat gtatgccctg     6480

aatataagta acaagttacc atgtcttgta aaatgatcat atcaacaaac atttaatgtg     6540

cacctactgt gctagttgaa tgtctttatc ctgataggag ataacaggat tccacatctt     6600

tgacttaaga ggacaaacca aatatgtcta aatcatttgg ggttttgatg gatatcttta     6660

aattgctgaa cctaatcatt ggtttcatat gtcattgttt agatatctcc ggagcatttg     6720

gataatgtga cagttggaat gcagtgatgt cgactctttg cccaccgcca tctccagctg     6780

ttgccaagac agagattgct ttaagtggca aatcaccttt attagcagct acttttgctt     6840

actgggacaa tattcttggt cctagagtaa ggcacatttg ggctccaaag acagaacagg     6900

tacttctcag tgatggagaa ataacttttc ttgccaacca cactctaaat ggagaaatcc     6960

ttcgaaatgc agagagtggt gctatagatg taaagttttt tgtcttgtct gaaaagggag     7020

tgattattgt ttcattaatc tttgatggaa actggaatgg ggatcgcagc acatatggac     7080

tatcaattat acttccacag acagaactta gtttctacct cccacttcat agagtgtgtg     7140

ttgatagatt aacacatata atccggaaag gaagaatatg gatgcataag gtaagtgatt     7200

tttcagctta ttaatcatgt taacctatct gttgaaagct tattttctgg tacatataaa     7260

tcttattttt ttaattatat gcagtgaaca tcaaacaata aatgttattt attttgcatt     7320

taccctatta gatacaaata catctggtct gatacctgtc atcttcatat taactgtgga     7380

aggtacgaaa tggtagctcc acattataga tgaaaagcta aagcttagac aaataaagaa     7440

acttttagac cctggattct tcttgggagc ctttgactct aatacctttt gtttcccttt     7500

cattgcacaa ttctgtcttt tgcttactac tatgtgtaag tataacagtt caaagtaata     7560

gtttcataag ctgttggtca tgtagccttt ggtctcttta acctctttgc caagttccca     7620

ggttcataaa atgaggaggt tgaatggaat ggttcccaag agaattcctt ttaatcttac     7680

agaaattatt gttttcctaa atcctgtagt tgaatatata atgctattta catttcagta     7740

tagttttgat gtatctaaag aacacattga attctccttc ctgtgttcca gtttgatact     7800

aacctgaaag tccattaagc attaccagtt ttaaaaggct tttgcccaat agtaaggaaa     7860

aataatatct tttaaaagaa taatttttta ctatgtttgc aggcttactt ccttttttct     7920

cacattatga aactcttaaa atcaggagaa tcttttaaac aacatcataa tgtttaattt     7980

gaaaagtgca agtcattctt ttcctttttg aaactatgca gatgttacat tgactgtttt     8040

ctgtgaagtt atcttttttt cactgcagaa taaaggttgt tttgatttta ttttgtattg     8100

tttatgagaa catgcatttg ttgggttaat ttcctacccc tgcccccatt ttttccctaa     8160

agtagaaagt atttttcttg tgaactaaat tactacacaa gaacatgtct attgaaaaat     8220

aagcaagtat caaaatgttg tgggttgttt ttttaaataa attttctctt gctcaggaaa     8280

gacaagaaaa tgtccagaag attatcttag aaggcacaga gagaatggaa gatcaggtat     8340

atgcaaattg catactgtca aatgtttttc tcacagcatg tatctgtata aggttgatgg     8400

ctacatttgt caaggccttg gagacatacg aataagcctt taatggagct tttatggagg     8460

tgtacagaat aaactggagg aagatttcca tatcttaaac ccaaagagtt aaatcagtaa     8520

acaaaggaaa atagtaattg catctacaaa ttaatatttg ctcccttttt ttttctgttt     8580

gcccagaata aattttggat aacttgttca tagtaaaaat aaaaaaaatt gtctctgata     8640

tgttctttaa ggtactactt ctcgaacctt tccctagaag tagctgtaac agaaggagag     8700

catatgtacc cctgaggtat ctgtctgggg tgtaggccca ggtccacaca atatttcttc     8760

taagtcttat gttgtatcgt taagactcat gcaatttaca ttttattcca taactatttt     8820

agtattaaaa tttgtcagtg atatttctta ccctctcctc taggaaaatg tgccatgttt     8880

atcccttggc tttgaatgcc cctcaggaac agacactaag agtttgagaa gcatggttac     8940

aagggtgtgg cttcccctgc ggaaactaag tacagactat ttcactgtaa agcagagaag     9000

ttcttttgaa ggagaatctc cagtgaagaa agagttcttc acttttactt ccatttcctc     9060

ttgtgggtga ccctcaatgc tccttgtaaa actccaatat tttaaacatg gctgttttgc     9120

ctttctttgc ttctttttag catgaatgag acagatgata ctttaaaaaa gtaattaaaa     9180

aaaaaaactt gtgaaaatac atggccataa tacagaaccc aatacaatga tctcctttac     9240

caaattgtta tgtttgtact tttgtagata gctttccaat tcagagacag ttattctgtg     9300

taaaggtctg acttaacaag aaaagatttc cctttaccca aagaatccca gtccttattt     9360

gctggtcaat aagcagggtc cccaggaatg gggtaacttt cagcaccctc taacccacta     9420

gttattagta gactaattaa gtaaacttat cgcaagttga ggaaacttag aaccaactaa     9480

aattctgctt ttactgggat tttgtttttt caaaccagaa acctttactt aagttgacta     9540

ctattaatga attttggtct ctcttttaag tgctcttctt aaaaatgtta tcttactgct     9600

gagaagttca agtttgggaa gtacaaggag gaatagaaac ttaagagatt ttcttttaga     9660

gcctcttctg tatttagccc tgtaggattt tttttttttt tttttttttt ggtgttgttg     9720

agcttcagtg aggctattca ttcacttata ctgataatgt ctgagatact gtgaatgaaa     9780

tactatgtat gcttaaacct aagaggaaat attttcccaa aattattctt cccgaaaagg     9840

aggagttgcc ttttgattga gttcttgcaa atctcacaac gactttattt tgaacaatac     9900

tgtttgggga tgatgcatta gtttgaaaca acttcagttg tagctgtcat ctgataaaat     9960

tgcttcacag ggaaggaaat ttaacacgga tctagtcatt attcttgtta gattgaatgt    10020

gtgaattgta attgtaaaca ggcatgataa ttattacttt aaaaactaaa aacagtgaat    10080

agttagttgt ggaggttact aaaggatggt ttttttttaa ataaaacttt cagcattatg    10140

caaatgggca tatggcttag gataaaactt ccagaagtag catcacattt aaattctcaa    10200

gcaacttaat aatatggggc tctgaaaaac tggttaaggt tactccaaaa atggccctgg    10260

gtctgacaaa gattctaact taaagatgct tatgaagact ttgagtaaaa tcatttcata    10320

aaataagtga ggaaaaacaa ctagtattaa attcatctta aataatgtat gatttaaaaa    10380

atatgtttag ctaaaaatgc atagtcattt gacaatttca tttatatctc aaaaaattta    10440

cttaaccaag ttggtcacaa aactgatgag actggtggtg gtagtgaata aatgagggac    10500

catccatatt tgagacactt tacatttgtg atgtgttata ctgaattttc agtttgattc    10560

tatagactac aaatttcaaa attacaattt caagatgtaa taagtagtaa tatcttgaaa    10620

tagctctaaa gggaattttt ctgttttatt gattcttaaa atatatgtgc tgattttgat    10680

ttgcatttgg gtagattata cttttatgag tatggaggtt aggtattgat tcaagttttc    10740

cttacctatt tggtaaggat ttcaaagtct ttttgtgctt ggttttcctc atttttaaat    10800

atgaaatata ttgatgacct ttaacaaatt ttttttatct caaattttaa aggagatctt    10860

ttctaaaaga ggcatgatga cttaatcatt gcatgtaaca gtaaacgata aaccaatgat    10920

tccatactct ctaaagaata aaagtgagct ttagggccgg gcatggtcag aaatttgaca    10980

ccaacctggc caacatggcg aaaccccgtc tctactaaaa atacaaaaat cagccgggca    11040

tggtggcggc acctatagtc ccagctactt gggaggatga gacaggagag tcacttgaac    11100

ctgggaggag aggttgcagt gagctgagat cacgccattg cactccagcc tgagcaatga    11160

aagcaaaact ccatctcaaa aaaaaaaaaa gaaaagaaag aataaaagtg agctttggat    11220

tgcatataaa tcctttagac atgtagtaga cttgtttgat actgtgtttg aacaaattac    11280

gaagtatttt catcaaagaa tgttattgtt tgatgttatt tttatttttt attgcccagc    11340

ttctctcata ttacgtgatt ttcttcactt catgtcactt tattgtgcag ggtcagagta    11400

ttattccaat gcttactgga gaagtgattc ctgtaatgga actgctttca tctatgaaat    11460

cacacagtgt tcctgaagaa atagatgtaa gtttaaatga gagcaattat acactttatg    11520

agttttttgg ggttatagta ttattatgta tattattaat attctaattt taatagtaag    11580

gactttgtca tacatactat tcacatacag tattagccac tttagcaaat aagcacacac    11640

aaaatcctgg attttatggc aaaacagagg catttttgat cagtgatgac aaaattaaat    11700

tcattttgtt tatttcatta cttttataat tcctaaaagt gggaggatcc cagctcttat    11760

aggagcaatt aatatttaat gtagtgtctt ttgaaacaaa actgtgtgcc aaagtagtaa    11820

ccattaatgg aagtttactt gtagtcacaa atttagtttc cttaatcatt tgttgaggac    11880

gttttgaatc acacactatg agtgttaaga gataccttta ggaaactatt cttgttgttt    11940

tctgattttg tcatttaggt tagtctcctg attctgacag ctcagaagag gaagttgttc    12000

ttgtaaaaat tgtttaacct gcttgaccag ctttcacatt tgttcttctg aagtttatgg    12060

tagtgcacag agattgtttt ttggggagtc ttgattctcg gaaatgaagg cagtgtgtta    12120

tattgaatcc agacttccga aaacttgtat attaaaagtg ttatttcaac actatgttac    12180

agccagacta atttttttat tttttgatgc attttagata gctgatacag tactcaatga    12240

tgatgatatt ggtgacagct gtcatgaagg ctttcttctc aagtaagaat ttttcttttc    12300

ataaaagctg gatgaagcag ataccatctt atgctcacct atgacaagat ttggaagaaa    12360

gaaaataaca gactgtctac ttagattgtt ctagggacat tacgtatttg aactgttgct    12420

taaatttgtg ttatttttca ctcattatat ttctatatat atttggtgtt attccatttg    12480

ctatttaaag aaaccgagtt tccatcccag acaagaaatc atggcccctt gcttgattct    12540

ggtttcttgt tttacttctc attaaagcta acagaatcct ttcatattaa gttgtactgt    12600

agatgaactt aagttattta ggcgtagaac aaaattattc atatttatac tgatcttttt    12660

ccatccagca gtggagttta gtacttaaga gtttgtgccc ttaaaccaga ctccctggat    12720

taatgctgtg tacccgtggg caaggtgcct gaattctcta tacacctatt tcctcatctg    12780

taaaatggca ataatagtaa tagtacctaa tgtgtagggt tgttataagc attgagtaag    12840

ataaataata taaagcactt agaacagtgc ctggaacata aaaacactta ataatagctc    12900

atagctaaca tttcctattt acatttcttc tagaaatagc cagtatttgt tgagtgccta    12960

catgttagtt cctttactag ttgctttaca tgtattatct tatattctgt tttaaagttt    13020

cttcacagtt acagattttc atgaaatttt acttttaata aaagagaagt aaaagtataa    13080

agtattcact tttatgttca cagtcttttc ctttaggctc atgatggagt atcagaggca    13140

tgagtgtgtt taacctaaga gccttaatgg cttgaatcag aagcacttta gtcctgtatc    13200

tgttcagtgt cagcctttca tacatcattt taaatcccat ttgactttaa gtaagtcact    13260

taatctctct acatgtcaat ttcttcagct ataaaatgat ggtatttcaa taaataaata    13320

cattaattaa atgatattat actgactaat tgggctgttt taaggctcaa taagaaaatt    13380

tctgtgaaag gtctctagaa aatgtaggtt cctatacaaa taaaagataa cattgtgctt    13440

atagcttcgg tgtttatcat ataaagctat tctgagttat ttgaagagct cacctacttt    13500

tttttgtttt tagtttgtta aattgtttta taggcaatgt ttttaatctg ttttctttaa    13560

cttacagtgc catcagctca cacttgcaaa cctgtggctg ttccgttgta gtaggtagca    13620

gtgcagagaa agtaaataag gtagtttatt ttataatcta gcaaatgatt tgactcttta    13680

agactgatga tatatcatgg attgtcattt aaatggtagg ttgcaattaa aatgatctag    13740

tagtataagg aggcaatgta atctcatcaa attgctaaga caccttgtgg caacagtgag    13800

tttgaaataa actgagtaag aatcatttat cagtttattt tgatagctcg gaaataccag    13860

tgtcagtagt gtataaatgg ttttgagaat atattaaaat cagatatata aaaaaaatta    13920

ctcttctatt tcccaatgtt atctttaaca aatctgaaga tagtcatgta cttttggtag    13980

tagttccaaa gaaatgttat ttgtttattc atcttgattt cattgtcttc gctttccttc    14040

taaatctgtc ccttctaggg agctattggg attaagtggt cattgattat tatactttat    14100

tcagtaatgt ttctgaccct ttccttcagt gctacttgag ttaattaagg attaatgaac    14160

agttacattt ccaagcatta gctaataaac taaaggattt tgcacttttc ttcactgacc    14220

attagttaga aagagttcag agataagtat gtgtatcttt caatttcagc aaacctaatt    14280

ttttaaaaaa agttttacat aggaaatatg ttggaaatga tactttacaa agatattcat    14340

aatttttttt tgtaatcagc tactttgtat atttacatga gccttaattt atatttctca    14400

tataaccatt tatgagagct tagtatacct gtgtcattat attgcatcta cgaactagtg    14460

accttattcc ttctgttacc tcaaacaggt ggctttccat ctgtgatctc caaagcctta    14520

ggttgcacag agtgactgcc gagctgcttt atgaagggag aaaggctcca tagttggagt    14580

gttttttttt ttttttttaa acatttttcc catcctccat cctcttgagg gagaatagct    14640

taccttttat cttgttttaa tttgagaaag aagttgccac cactctaggt tgaaaaccac    14700

tcctttaaca taataactgt ggatatggtt tgaatttcaa gatagttaca tgccttttta    14760

tttttcctaa tagagctgta ggtcaaatat tattagaatc agatttctaa atcccaccca    14820

atgacctgct tattttaaat caaattcaat aattaattct cttctttttg gaggatctgg    14880

acattctttg atatttctta caacgaattt catgtgtaga cccactaaac agaagctata    14940

aaagttgcat ggtcaaataa gtctgagaaa gtctgcagat gatataattc acctgaagag    15000

tcacagtatg tagccaaatg ttaaaggttt tgagatgcca tacagtaaat ttaccaagca    15060

ttttctaaat ttatttgacc acagaatccc tattttaagc aacaactgtt acatcccatg    15120

gattccaggt gactaaagaa tacttatttc ttaggatatg ttttattgat aataacaatt    15180

aaaatttcag atatctttca taagcaaatc agtggtcttt ttacttcatg ttttaatgct    15240

aaaatatttt cttttataga tagtcagaac attatgcctt tttctgactc cagcagagag    15300

aaaatgctcc aggttatgtg aagcagaatc atcatttaaa tatgagtcag ggctctttgt    15360

acaaggcctg ctaaaggtat agtttctagt tatcacaagt gaaaccactt ttctaaaatc    15420

atttttgaga ctctttatag acaaatctta aatattagca tttaatgtat ctcatattga    15480

catgcccaga gactgacttc ctttacacag ttctgcacat agactatatg tcttatggat    15540

ttatagttag tatcatcagt gaaacaccat agaataccct ttgtgttcca ggtgggtccc    15600

tgttcctaca tgtctagcct caggactttt ttttttttaa cacatgctta aatcaggttg    15660

cacatcaaaa ataagatcat ttctttttaa ctaaatagat ttgaatttta ttgaaaaaaa    15720

attttaaaca tctttaagaa gcttatagga tttaagcaat tcctatgtat gtgtactaaa    15780

atatatatat ttctatatat aatatatatt agaaaaaaat tgtatttttc ttttatttga    15840

gtctactgtc aaggagcaaa acagagaaat gtaaattagc aattatttat aatacttaaa    15900

gggaagaaag ttgttcacct tgttgaatct attattgtta tttcaattat agtcccaaga    15960

cgtgaagaaa tagctttcct aatggttatg tgattgtctc atagtgacta ctttcttgag    16020

gatgtagcca cggcaaaatg aaataaaaaa atttaaaaat tgttgcaaat acaagttata    16080

ttaggctttt gtgcattttc aataatgtgc tgctatgaac tcagaatgat agtatttaaa    16140

tatagaaact agttaaagga aacgtagttt ctatttgagt tatacatatc tgtaaattag    16200

aacttctcct gttaaaggca taataaagtg cttaatactt ttgtttcctc agcaccctct    16260

catttaatta tataatttta gttctgaaag ggacctatac cagatgccta gaggaaattt    16320

caaaactatg atctaatgaa aaaatattta atagttctcc atgcaaatac aaatcatata    16380

gttttccaga aaataccttt gacattatac aaagatgatt atcacagcat tataatagta    16440

aaaaaatgga aatagcctct ttcttctgtt ctgttcatag cacagtgcct catacgcagt    16500

aggttattat tacatggtaa ctggctaccc caactgatta ggaaagaagt aaatttgttt    16560

tataaaaata catactcatt gaggtgcata gaataattaa gaaattaaaa gacacttgta    16620

attttgaatc cagtgaatac ccactgttaa tatttggtat atctctttct agtctttttt    16680

tcccttttgc atgtattttc tttaagactc ccacccccac tggatcatct ctgcatgttc    16740

taatctgctt ttttcacagc agattctaag cctctttgaa tatcaacaca aacttcaaca    16800

acttcatcta tagatgccaa ataataaatt catttttatt tacttaacca cttcctttgg    16860

atgcttaggt cattctgatg ttttgctatt gaaaccaatg ctatactgaa cacttctgtc    16920

actaaaactt tgcacacact catgaatagc ttcttaggat aaatttttag agatggattt    16980

gctaaatcag agaccatttt ttaaaattaa aaaacaatta ttcatatcgt ttggcatgta    17040

agacagtaaa ttttcctttt attttgacag gattcaactg gaagctttgt gctgcctttc    17100

cggcaagtca tgtatgctcc atatcccacc acacacatag atgtggatgt caatactgtg    17160

aagcagatgc caccctgtca tgaacatatt tataatcagc gtagatacat gagatccgag    17220

ctgacagcct tctggagagc cacttcagaa gaagacatgg ctcaggatac gatcatctac    17280

actgacgaaa gctttactcc tgatttgtac gtaatgctct gcctgctggt actgtagtca    17340

agcaatatga aattgtgtct tttacgaata aaaacaaaac agaagttgca tttaaaaaga    17400

aagaaatatt accagcagaa ttatgcttga agaaacattt aatcaagcat ttttttctta    17460

aatgttcttc tttttccata caattgtgtt taccctaaaa taggtaagat taacccttaa    17520

agtaaatatt taactatttg tttaataaat atatattgag ctcctaggca ctgttctagg    17580

taccgggctt aatagtggcc aaccagacag ccccagcccc agcccctaca ttgtgtatag    17640

tctattatgt aacagttatt gaatggactt attaacaaaa ccaaagaagt aattctaagt    17700

cttttttttc ttgacatatg aatataaaat acagcaaaac tgttaaaata tattaatgga    17760

acattttttt actttgcatt ttatattgtt attcacttct tatttttttt taaaaaaaaa    17820

agcctgaaca gtaaattcaa aaggaaaagt aatgataatt aattgttgag catggaccca    17880

acttgaaaaa aaaaatgatg atgataaatc tataatccta aaaccctaag taaacactta    17940

aaagatgttc tgaaatcagg aaaagaatta tagtatactt ttgtgtttct cttttatcag    18000

ttgaaaaaag gcacagtagc tcatgcctgt aagaacagag ctttgggagt gcaaggcagg    18060

cggatcactt gaggccagga gttccagacc agcctgggca acatagtgaa accccatctc    18120

tacaaaaaat aaaaaagaat tattggaatg tgtttctgtg tgcctgtaat cctagctatt    18180

ccgaaagctg aggcaggagg atcttttgag cccaggagtt tgaggttaca gggagttatg    18240

atgtgccagt gtactccagc ctggggaaca ccgagactct gtcttattta aaaaaaaaaa    18300

aaaaaaaatg cttgcaataa tgcctggcac atagaaggta acagtaagtg ttaactgtaa    18360

taacccaggt ctaagtgtgt aaggcaatag aaaaattggg gcaaataagc ctgacctatg    18420

tatctacaga atcagtttga gcttaggtaa cagacctgtg gagcaccagt aattacacag    18480

taagtgttaa ccaaaagcat agaataggaa tatcttgttc aagggacccc cagccttata    18540

catctcaagg tgcagaaaga tgacttaata taggacccat tttttcctag ttctccagag    18600

tttttattgg ttcttgagaa agtagtaggg gaatgtttta gaaaatgaat tggtccaact    18660

gaaattacat gtcagtaagt ttttatatat tggtaaattt tagtagacat gtagaagttt    18720

tctaattaat ctgtgccttg aaacattttc ttttttccta aagtgcttag tattttttcc    18780

gttttttgat tggttacttg ggagcttttt tgaggaaatt tagtgaactg cagaatgggt    18840

ttgcaaccat ttggtatttt tgttttgttt tttagaggat gtatgtgtat tttaacattt    18900

cttaatcatt tttagccagc tatgtttgtt ttgctgattt gacaaactac agttagacag    18960

ctattctcat tttgctgatc atgacaaaat aatatcctga atttttaaat tttgcatcca    19020

gctctaaatt ttctaaacat aaaattgtcc aaaaaatagt attttcagcc actagattgt    19080

gtgttaagtc tattgtcaca gagtcatttt acttttaagt atatgttttt acatgttaat    19140

tatgtttgtt atttttaatt ttaacttttt aaaataattc cagtcactgc caatacatga    19200

aaaattggtc actggaattt tttttttgac ttttatttta ggttcatgtg tacatgtgca    19260

ggtgtgttat acaggtaaat tgcgtgtcat gagggtttgg tgtacaggtg atttcattac    19320

ccaggtaata agcatagtac ccaataggta gttttttgat cctcaccctt ctcccaccct    19380

caagtaggcc ctggtgttgc tgtttccttc tttgtgtcca tgtatactca gtgtttagct    19440

cccacttaga agtgagaaca tgcggtagtt ggttttctgt tcctggatta gttcacttag    19500

gataatgacc tctagctcca tctggttttt atggctgcat agtattccat ggtgtatatg    19560

tatcacattt tctttatcca gtctaccatt gataggcatt taggttgatt ccctgtcttt    19620

gttatcatga atagtgctgt gatgaacata cacatgcatg tgtctttatg gtagaaaaat    19680

ttgtattcct ttaggtacat atagaataat ggggttgcta gggtgaatgg tagttctatt    19740

ttcagttatt tgagaaatct tcaaactgct tttcataata gctaaactaa tttacagtcc    19800

cgccagcagt gtataagtgt tcccttttct ccacaacctt gccaacatct gtgatttttt    19860

gactttttaa taatagccat tcctagagaa ttgatttgca attctctatt agtgatatta    19920

agcatttttt catatgcttt ttagctgtct gtatatattc ttctgaaaaa ttttcatgtc    19980

ctttgcccag tttgtagtgg ggtgggttgt tttttgcttg ttaattagtt ttaagttcct    20040

tccagattct gcatatccct ttgttggata catggtttgc agatattttt ctcccattgt    20100

gtaggttgtc ttttactctg ttgatagttt cttttgccat gcaggagctc gttaggtccc    20160

atttgtgttt gtttttgttg cagttgcttt tggcgtcttc atcataaaat ctgtgccagg    20220

gcctatgtcc agaatggtat ttcctaggtt gtcttccagg gtttttacaa ttttagattt    20280

tacgtttatg tctttaatcc atcttgagtt gatttttgta tatggcacaa ggaaggggtc    20340

cagtttcact ccaattccta tggctagcaa ttatcccagc accatttatt gaatacggag    20400

tcctttcccc attgcttgtt ttttgtcaac tttgttgaag atcagatggt tgtaagtgtg    20460

tggctttatt tcttggctct ctattctcca ttggtctatg tgtctgtttt tataacagta    20520

ccctgctgtt caggttccta tagcctttta gtataaaatc ggctaatgtg atgcctccag    20580

ctttgttctt tttgcttagg attgctttgg ctatttgggc tcctttttgg gtccatatta    20640

attttaaaac agttttttct ggttttgtga aggatatcat tggtagttta taggaatagc    20700

attgaatctg tagattgctt tgggcagtat ggccatttta acaatattaa ttcttcctat    20760

ctatgaatat ggaatgtttt tccatgtgtt tgtgtcatct ctttatacct gatgtataaa    20820

gaaaagctgg tattattcct actcaatctg ttccaaaaaa ttgaggagga ggaactcttc    20880

cctaatgagg ccagcatcat tctgatacca aaacctggca gagacacaac agaaaaaaga    20940

aaacttcagg ccaatatcct tgatgaatat agatgcaaaa atcctcaaca aaatactagc    21000

aaaccaaatc cagcagcaca tcaaaaagct gatctacttt gatcaagtag gctttatccc    21060

tgggatgcaa ggttggttca acatacacaa atcaataagt gtgattcatc acataaacag    21120

agctaaaaac aaaaaccaca agattatctc aataggtaga gaaaaggttg tcaataaaat    21180

ttaacatcct ccatgttaaa aaccttcagt aggtcaggtg tagtgactca cacctgtaat    21240

cccagcactt tgggaggcca aggcgggcat atctcttaag cccaggagtt caagacgagc    21300

ctaggcagca tggtgaaacc ccatctctac aaaaaaaaaa aaaaaaaaaa attagcttgg    21360

tatggtgaca tgcacctata gtcccagcta ttcaggaggt tgaggtggga ggattgtttg    21420

agcccgggag gcagaggttg gcagcgagct gagatcatgc caccgcactc cagcctgggc    21480

aacggagtga gaccctgtct caaaaaagaa aaatcacaaa caatcctaaa caaactaggc    21540

attgaaggaa catgcctcaa aaaaataaga accatctatg acagacccat agccaatatc    21600

ttaccaaatg ggcaaaagct ggaagtattc tccttgagaa ccgtaacaag acaaggatgt    21660

ccactctcac cactcctttt cagcatagtt ctggaagtcc tagccagagc aatcaggaaa    21720

gagaaagaaa gaaagacatt cagataggaa gagaagaagt caaactattt ctgtttgcag    21780

gcagtataat tctgtaccta gaaaatctca tagtctctgc ccagaaactc ctaaatctgt    21840

taaaaatttc agcaaagttt tggcattctc tatactccaa caccttccaa agtgagagca    21900

aaatcaagaa cacagtccca ttcacaatag ccgcaaaacg aataaaatac ctaggaatcc    21960

agctaaccag ggaggtgaaa gatctctatg agaattacaa aacactgctg aaagaaatca    22020

gagatgacac aaacaaatgg aaatgttctt ttttaacacc ttgctttatc taattcactt    22080

atgatgaaga tactcattca gtggaacagg tataataagt ccactcgatt aaatataagc    22140

cttattctct ttccagagcc caagaagggg cactatcagt gcccagtcaa taatgacgaa    22200

atgctaatat ttttcccctt tacggtttct ttcttctgta gtgtggtaca ctcgtttctt    22260

aagataagga aacttgaact accttcctgt ttgcttctac acatacccat tctctttttt    22320

tgccactctg gtcaggtata ggatgatccc taccactttc agttaaaaac tcctcctctt    22380

actaaatgtt ctcttaccct ctggcctgag tagaacctag ggaaaatgga agagaaaaag    22440

atgaaaggga ggtggggcct gggaagggaa taagtagtcc tgtttgtttg tgtgtttgct    22500

ttagcacctg ctatatccta ggtgctgtgt taggcacaca ttattttaag tggccattat    22560

attactacta ctcactctgg tcgttgccaa ggtaggtagt actttcttgg atagttggtt    22620

catgttactt acagatggtg ggcttgttga ggcaaaccca gtggataatc atcggagtgt    22680

gttctctaat ctcactcaaa tttttcttca cattttttgg tttgttttgg tttttgatgg    22740

tagtggctta tttttgttgc tggtttgttt tttgtttttt tttgagatgg caagaattgg    22800

tagttttatt tattaattgc ctaagggtct ctactttttt taaaagatga gagtagtaaa    22860

atagattgat agatacatac atacccttac tggggactgc ttatattctt tagagaaaaa    22920

attacatatt agcctgacaa acaccagtaa aatgtaaata tatccttgag taaataaatg    22980

aatgtatatt ttgtgtctcc aaatatatat atctatattc ttacaaatgt gtttatatgt    23040

aatatcaatt tataagaact taaaatgttg gctcaagtga gggattgtgg aaggtagcat    23100

tatatggcca tttcaacatt tgaacttttt tcttttcttc attttcttct tttcttcagg    23160

aatatttttc aagatgtctt acacagagac actctagtga aagccttcct ggatcaggta    23220

aatgttgaac ttgagattgt cagagtgaat gatatgacat gttttctttt ttaatatatc    23280

ctacaatgcc tgttctatat atttatattc ccctggatca tgccccagag ttctgctcag    23340

caattgcagt taagttagtt acactacagt tctcagaaga gtctgtgagg gcatgtcaag    23400

tgcatcatta cattggttgc ctcttgtcct agatttatgc ttcgggaatt cagacctttg    23460

tttacaatat aataaatatt attgctatct tttaaagata taataataag atataaagtt    23520

gaccacaact actgtttttt gaaacataga attcctggtt tacatgtatc aaagtgaaat    23580

ctgacttagc ttttacagat ataatatata catatatata tcctgcaatg cttgtactat    23640

atatgtagta caagtatata tatatgtttg tgtgtgtata tatatatagt acgagcatat    23700

atacatatta ccagcattgt aggatatata tatgtttata tattaaaaaa aagttataaa    23760

cttaaaaccc tattatgtta tgtagagtat atgttatata tgatatgtaa aatatataac    23820

atatactcta tgatagagtg taatatattt tttatatata ttttaacatt tataaaatga    23880

tagaattaag aattgagtcc taatctgttt tattaggtgc tttttgtagt gtctggtctt    23940

tctaaagtgt ctaaatgatt tttccttttg acttattaat ggggaagagc ctgtatatta    24000

acaattaaga gtgcagcatt ccatacgtca aacaacaaac attttaattc aagcattaac    24060

ctataacaag taagtttttt tttttttttt gagaaaggga ggttgtttat ttgcctgaaa    24120

tgactcaaaa atatttttga aacatagtgt acttatttaa ataacatctt tattgtttca    24180

ttcttttaaa aaatatctac ttaattacac agttgaagga aatcgtagat tatatggaac    24240

ttatttctta atatattaca gtttgttata ataacattct ggggatcagg ccaggaaact    24300

gtgtcataga taaagctttg aaataatgag atccttatgt ttactagaaa ttttggattg    24360

agatctatga ggtctgtgac atattgcgaa gttcaaggaa aattcgtagg cctggaattt    24420

catgcttctc aagctgacat aaaatccctc ccactctcca cctcatcata tgcacacatt    24480

ctactcctac ccacccactc caccccctgc aaaagtacag gtatatgaat gtctcaaaac    24540

cataggctca tcttctagga gcttcaatgt tatttgaaga tttgggcaga aaaaattaag    24600

taatacgaaa taacttatgt atgagtttta aaagtgaagt aaacatggat gtattctgaa    24660

gtagaatgca aaatttgaat gcatttttaa agataaatta gaaaacttct aaaaactgtc    24720

agattgtctg ggcctggtgg cttatgcctg taatcccagc actttgggag tccgaggtgg    24780

gtggatcaca aggtcaggag atcgagacca tcctgccaac atggtgaaac cccgtctcta    24840

ctaagtatac aaaaattagc tgggcgtggc agcgtgtgcc tgtaatccca gctacctggg    24900

aggctgaggc aggagaatcg cttgaaccca ggaggtgtag gttgcagtga gtcaagatcg    24960

cgccactgca ctttagcctg gtgacagagc tagactccgt ctcaaaaaaa aaaaaaaata    25020

tcagattgtt cctacaccta gtgcttctat accacactcc tgttaggggg catcagtgga    25080

aatggttaag gagatgttta gtgtgtattg tctgccaagc actgtcaaca ctgtcataga    25140

aacttctgta cgagtagaat gtgagcaaat tatgtgttga aatggttcct ctccctgcag    25200

gtctttcagc tgaaacctgg cttatctctc agaagtactt tccttgcaca gtttctactt    25260

gtccttcaca gaaaagcctt gacactaata aaatatatag aagacgatac gtgagtaaaa    25320

ctcctacacg gaagaaaaac ctttgtacat tgtttttttg ttttgtttcc tttgtacatt    25380

ttctatatca taatttttgc gcttcttttt tttttttttt tttttttttt tccattattt    25440

ttaggcagaa gggaaaaaag ccctttaaat ctcttcggaa cctgaagata gaccttgatt    25500

taacagcaga gggcgatctt aacataataa tggctctggc tgagaaaatt aaaccaggcc    25560

tacactcttt tatctttgga agacctttct acactagtgt gcaagaacga gatgttctaa    25620

tgacttttta aatgtgtaac ttaataagcc tattccatca caatcatgat cgctggtaaa    25680

gtagctcagt ggtgtgggga aacgttcccc tggatcatac tccagaattc tgctctcagc    25740

aattgcagtt aagtaagtta cactacagtt ctcacaagag cctgtgaggg gatgtcaggt    25800

gcatcattac attgggtgtc tcttttccta gatttatgct tttgggatac agacctatgt    25860

ttacaatata ataaatatta ttgctatctt ttaaagatat aataatagga tgtaaacttg    25920

accacaacta ctgttttttt gaaatacatg attcatggtt tacatgtgtc aaggtgaaat    25980

ctgagttggc ttttacagat agttgacttt ctatcttttg gcattctttg gtgtgtagaa    26040

ttactgtaat acttctgcaa tcaactgaaa actagagcct ttaaatgatt tcaattccac    26100

agaaagaaag tgagcttgaa cataggatga gctttagaaa gaaaattgat caagcagatg    26160

tttaattgga attgattatt agatcctact ttgtggattt agtccctggg attcagtctg    26220

tagaaatgtc taatagttct ctatagtcct tgttcctggt gaaccacagt tagggtgttt    26280

tgtttatttt attgttcttg ctattgttga tattctatgt agttgagctc tgtaaaagga    26340

aattgtattt tatgttttag taattgttgc caacttttta aattaatttt cattattttt    26400

gagccaaatt gaaatgtgca cctcctgtgc cttttttctc cttagaaaat ctaattactt    26460

ggaacaagtt cagatttcac tggtcagtca ttttcatctt gttttcttct tgctaagtct    26520

taccatgtac ctgctttggc aatcattgca actctgagat tataaaatgc cttagagaat    26580

atactaacta ataagatctt tttttcagaa acagaaaata gttccttgag tacttccttc    26640

ttgcatttct gcctatgttt ttgaagttgt tgctgtttgc ctgcaatagg ctataaggaa    26700

tagcaggaga aattttactg aagtgctgtt ttcctaggtg ctactttggc agagctaagt    26760

tatcttttgt tttcttaatg cgtttggacc attttgctgg ctataaaata actgattaat    26820

ataattctaa cacaatgttg acattgtagt tacacaaaca caaataaata ttttatttaa    26880

aattctggaa gtaatataaa agggaaaata tatttataag aaagggataa aggtaataga    26940

gcccttctgc cccccaccca ccaaatttac acaacaaaat gacatgttcg aatgtgaaag    27000

gtcataatag ctttcccatc atgaatcaga aagatgtgga cagcttgatg ttttagacaa    27060

ccactgaact agatgactgt tgtactgtag ctcagtcatt taaaaaatat ataaatacta    27120

ccttgtagtg tcccatactg tgttttttac atggtagatt cttatttaag tgctaactgg    27180

ttattttctt tggctggttt attgtactgt tatacagaat gtaagttgta cagtgaaata    27240

agttattaaa gcatgtgtaa acattgttat atatcttttc tcctaaatgg agaattttga    27300

ataaaatata tttgaaattt tg                                             27322


<210>  57
<211>  5502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S92RNL (Sense GR-Nanoluciferase reporter plasmid)

<400>  57
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa       60

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata      120

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag      180

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc      240

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta      300

cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg      360

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      420

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      480

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      540

gtctatataa gcagagctcg tttagtgaac cgtcagatca ctagaagctt tattgcggta      600

gtttatcaca gttaaattgc taacgcagtc agtgcttctg acacaacagt ctcgaactta      660

agctgcagaa gttggtcgtg aggcactggg caggtaagta tcaaggttac aagacaggtt      720

taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag      780

gcacctattg gtcttactga catccacttt gcctttctct ccacaggtgt ccactcccag      840

ttcaattaca gctcttaagg ctagagtact taatacgact cactataggg atatctgctt      900

atcgataccg tcgacctcga atcactagtc agctggaatt cctcacagta ctcgctgagg      960

gtgaacaaga aaagacctga taaagattaa ccagaagaaa acaaggaggg aaacaaccgc     1020

agcctgtagc aagctctgga actcaggagt cgcgcgctag ctcttcaggc cggggccggg     1080

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1140

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1200

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1260

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1320

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1380

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1440

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1500

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1560

gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc cggggccggg     1620

gcctgcggcc gctggtcttc acactcgaag atttcgttgg ggactggcga cagacagccg     1680

gctacaacct ggaccaagtc cttgaacagg gaggtgtgtc cagtttgttt cagaatctcg     1740

gggtgtccgt aactccgatc caaaggattg tcctgagcgg tgaaaatggg ctgaagatcg     1800

acatccatgt catcatcccg tatgaaggtc tgagcggcga ccaaatgggc cagatcgaaa     1860

aaatttttaa ggtggtgtac cctgtggatg atcatcactt taaggtgatc ctgcactatg     1920

gcacactggt aatcgacggg gttacgccga acatgatcga ctatttcgga cggccgtatg     1980

aaggcatcgc cgtgttcgac ggcaaaaaga tcactgtaac agggaccctg tggaacggca     2040

acaaaattat cgacgagcgc ctgatcaacc ccgacggctc cctgctgttc cgagtaacca     2100

tcaacggagt gaccggctgg cggctgtgcg aacgcattct ggcgtaattc tagagtcggg     2160

gcggccggcc gcttcgagca gacatgataa gatacattga tgagtttgga caaaccacaa     2220

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     2280

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     2340

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     2400

aaatcgataa ggatctgaac gatggagcgg agaatgggcg gaactgggcg gagttagggg     2460

cgggatgggc ggagttaggg gcgggactat ggttgctgac taattgagat gcatgctttg     2520

catacttctg cctgctgggg agcctgggga ctttccacac ctggttgctg actaattgag     2580

atgcatgctt tgcatacttc tgcctgctgg ggagcctggg gactttccac accctaactg     2640

acacacattc cacagcggat ccgtcgaccg atgcccttga gagccttcaa cccagtcagc     2700

tccttccggt gggcgcgggg catgactatc gtcgccgcac ttatgactgt cttctttatc     2760

atgcaactcg taggacaggt gccggcagcg ctgttccgct tcctcgctca ctgactcgct     2820

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     2880

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc     2940

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     3000

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     3060

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     3120

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     3180

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     3240

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     3300

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     3360

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     3420

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     3480

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     3540

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     3600

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     3660

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     3720

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     3780

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt     3840

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     3900

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     3960

cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     4020

tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg     4080

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     4140

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     4200

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     4260

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     4320

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac     4380

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     4440

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     4500

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     4560

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat attattgaag     4620

catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa     4680

acaaataggg gttccgcgca catttccccg aaaagtgcca cctgacgcgc cctgtagcgg     4740

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     4800

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     4860

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     4920

cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac     4980

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     5040

tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat     5100

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     5160

aatattaacg cttacaattt gccattcgcc attcaggctg cgcaactgtt gggaagggcg     5220

atcggtgcgg gcctcttcgc tattacgcca gcccaagcta ccatgataag taagtaatat     5280

taaggtacgg gaggtactgg ccgcaataaa atatctttat tttcattaca tctgtgtgtt     5340

ggttttttgt gtgaatcgat agtactaaca tacgctctcc atcaaaacaa aacgaaacaa     5400

aacaaactag caaaataggc tgtccccagt gcaagtgcag gtgccagaac atttctctat     5460

cgataggtac cgagctctta cgcgtgctag cccgggctcg ag                        5502


<210>  58
<211>  6099
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS55RNL Nanoluciferase reporter plasmid

<400>  58
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa       60

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata      120

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag      180

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc      240

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta      300

cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg      360

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      420

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      480

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      540

gtctatataa gcagagctcg tttagtgaac cgtcagatca ctagaagctt tattgcggta      600

gtttatcaca gttaaattgc taacgcagtc agtgcttctg acacaacagt ctcgaactta      660

agctgcagaa gttggtcgtg aggcactggg caggtaagta tcaaggttac aagacaggtt      720

taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag      780

gcacctattg gtcttactga catccacttt gcctttctct ccacaggtgt ccactcccag      840

ttcaattaca gctcttaagg ctagagtact taatacgact cactataggg atatcgaatt      900

caatagtcac ttcctttaag caagtctgtg tcatctcgga gctgtgaagc aaccaggtca      960

tgtcccacag aatggggagc acaccgactt gcattgctgc cctcatatgc aagtcatcac     1020

cactctctag aagcttgggc tgaaattgtg caggcgtctc cacaccccca tctcatcccg     1080

catgatctcc tcgccggcag ggaccgtctc gggttcctag cgaaccccga cttggtccgc     1140

agaagccgcg cgccgcccac cctccggcct tcccccaggc gaggcctctc agtacccgag     1200

gctccctttt ctcgagcccg cagcggcagc gctcccagcg ggtccccggg aaggagacag     1260

ctcgggtact gagggcggga aagcaaggaa gaggccagat ccccatccct tgtccctgcg     1320

ccgccgccgc cgccgccgcc gccgggaagc cgaattccgg ggcccggatg caggcaattc     1380

caccagtcgc tagaggcgaa agcccgacac ccagcttcgg tcagagaaat gagagggaaa     1440

gtaaaaatgc gtcgagctct gaggagagcc cccgcttcta cccgcgcctc ttcccggcag     1500

ccgaacccca aacagccacc cgccaggatg ccgcctcctc actcacccac tcgccaccgc     1560

ctgcgcctcc gccgccgcgg gcgcaggcac cgcaaccgca gccccgcccc gggcccgccc     1620

ccgggcccgc cccgaccacg agcggccgca ggccccggcc ccggccccgg ccccggcccc     1680

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     1740

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     1800

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     1860

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     1920

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     1980

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     2040

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     2100

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg ccccggcccc     2160

ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccacta gtcagctgga     2220

attggccgct ggtcttcaca ctcgaagatt tcgttgggga ctggcgacag acagccggct     2280

acaacctgga ccaagtcctt gaacagggag gtgtgtccag tttgtttcag aatctcgggg     2340

tgtccgtaac tccgatccaa aggattgtcc tgagcggtga aaatgggctg aagatcgaca     2400

tccatgtcat catcccgtat gaaggtctga gcggcgacca aatgggccag atcgaaaaaa     2460

tttttaaggt ggtgtaccct gtggatgatc atcactttaa ggtgatcctg cactatggca     2520

cactggtaat cgacggggtt acgccgaaca tgatcgacta tttcggacgg ccgtatgaag     2580

gcatcgccgt gttcgacggc aaaaagatca ctgtaacagg gaccctgtgg aacggcaaca     2640

aaattatcga cgagcgcctg atcaaccccg acggctccct gctgttccga gtaaccatca     2700

acggagtgac cggctggcgg ctgtgcgaac gcattctggc gtaattctag agtcggggcg     2760

gccggccgct tcgagcagac atgataagat acattgatga gtttggacaa accacaacta     2820

gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa     2880

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg     2940

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa     3000

tcgataagga tctgaacgat ggagcggaga atgggcggaa ctgggcggag ttaggggcgg     3060

gatgggcgga gttaggggcg ggactatggt tgctgactaa ttgagatgca tgctttgcat     3120

acttctgcct gctggggagc ctggggactt tccacacctg gttgctgact aattgagatg     3180

catgctttgc atacttctgc ctgctgggga gcctggggac tttccacacc ctaactgaca     3240

cacattccac agcggatccg tcgaccgatg cccttgagag ccttcaaccc agtcagctcc     3300

ttccggtggg cgcggggcat gactatcgtc gccgcactta tgactgtctt ctttatcatg     3360

caactcgtag gacaggtgcc ggcagcgctg ttccgcttcc tcgctcactg actcgctgcg     3420

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     3480

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag     3540

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     3600

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     3660

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     3720

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     3780

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     3840

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     3900

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     3960

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt     4020

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     4080

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     4140

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     4200

gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta     4260

gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg     4320

gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg     4380

ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc     4440

atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc     4500

agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc     4560

ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag     4620

tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat     4680

ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg     4740

caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt     4800

gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag     4860

atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg     4920

accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt     4980

aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct     5040

gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac     5100

tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat     5160

aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat     5220

ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca     5280

aataggggtt ccgcgcacat ttccccgaaa agtgccacct gacgcgccct gtagcggcgc     5340

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct     5400

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg     5460

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga     5520

ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt     5580

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg     5640

aacaacactc aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc     5700

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat     5760

attaacgctt acaatttgcc attcgccatt caggctgcgc aactgttggg aagggcgatc     5820

ggtgcgggcc tcttcgctat tacgccagcc caagctacca tgataagtaa gtaatattaa     5880

ggtacgggag gtactggccg caataaaata tctttatttt cattacatct gtgtgttggt     5940

tttttgtgtg aatcgatagt actaacatac gctctccatc aaaacaaaac gaaacaaaac     6000

aaactagcaa aataggctgt ccccagtgca agtgcaggtg ccagaacatt tctctatcga     6060

taggtaccga gctcttacgc gtgctagccc gggctcgag                            6099


<210>  59
<211>  4944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S0RNL Nanoluciferase reporter plasmid

<400>  59
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa       60

cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata      120

atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag      180

tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtccgccc      240

cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta      300

cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg      360

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      420

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      480

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      540

gtctatataa gcagagctcg tttagtgaac cgtcagatca ctagaagctt tattgcggta      600

gtttatcaca gttaaattgc taacgcagtc agtgcttctg acacaacagt ctcgaactta      660

agctgcagaa gttggtcgtg aggcactggg caggtaagta tcaaggttac aagacaggtt      720

taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag      780

gcacctattg gtcttactga catccacttt gcctttctct ccacaggtgt ccactcccag      840

ttcaattaca gctcttaagg ctagagtact taatacgact cactataggg atatctgctt      900

atcgataccg tcgacctcga atcactagtc agctggaatt cctcacagta ctcgctgagg      960

gtgaacaaga aaagacctga taaagattaa ccagaagaaa acaaggaggg aaacaaccgc     1020

agcctgtagc aagctctgga actcaggagt cgcgcgctag ggggctctgg ccgctggtct     1080

tcacactcga agatttcgtt ggggactggc gacagacagc cggctacaac ctggaccaag     1140

tccttgaaca gggaggtgtg tccagtttgt ttcagaatct cggggtgtcc gtaactccga     1200

tccaaaggat tgtcctgagc ggtgaaaatg ggctgaagat cgacatccat gtcatcatcc     1260

cgtatgaagg tctgagcggc gaccaaatgg gccagatcga aaaaattttt aaggtggtgt     1320

accctgtgga tgatcatcac tttaaggtga tcctgcacta tggcacactg gtaatcgacg     1380

gggttacgcc gaacatgatc gactatttcg gacggccgta tgaaggcatc gccgtgttcg     1440

acggcaaaaa gatcactgta acagggaccc tgtggaacgg caacaaaatt atcgacgagc     1500

gcctgatcaa ccccgacggc tccctgctgt tccgagtaac catcaacgga gtgaccggct     1560

ggcggctgtg cgaacgcatt ctggcgtaat tctagagtcg gggcggccgg ccgcttcgag     1620

cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa     1680

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca     1740

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt     1800

gggaggtttt ttaaagcaag taaaacctct acaaatgtgg taaaatcgat aaggatctga     1860

acgatggagc ggagaatggg cggaactggg cggagttagg ggcgggatgg gcggagttag     1920

gggcgggact atggttgctg actaattgag atgcatgctt tgcatacttc tgcctgctgg     1980

ggagcctggg gactttccac acctggttgc tgactaattg agatgcatgc tttgcatact     2040

tctgcctgct ggggagcctg gggactttcc acaccctaac tgacacacat tccacagcgg     2100

atccgtcgac cgatgccctt gagagccttc aacccagtca gctccttccg gtgggcgcgg     2160

ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact cgtaggacag     2220

gtgccggcag cgctgttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     2280

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     2340

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     2400

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     2460

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     2520

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     2580

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     2640

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     2700

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     2760

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     2820

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     2880

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     2940

cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc     3000

tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg     3060

ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta     3120

aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca     3180

atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc     3240

ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc     3300

tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc     3360

agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat     3420

taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt     3480

tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc     3540

cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag     3600

ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt     3660

tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac     3720

tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg     3780

cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat     3840

tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc     3900

gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     3960

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     4020

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg     4080

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     4140

cacatttccc cgaaaagtgc cacctgacgc gccctgtagc ggcgcattaa gcgcggcggg     4200

tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt     4260

cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg     4320

ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga     4380

ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac     4440

gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc     4500

tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa     4560

aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgcttacaat     4620

ttgccattcg ccattcaggc tgcgcaactg ttgggaaggg cgatcggtgc gggcctcttc     4680

gctattacgc cagcccaagc taccatgata agtaagtaat attaaggtac gggaggtact     4740

ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgaatcg     4800

atagtactaa catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag     4860

gctgtcccca gtgcaagtgc aggtgccaga acatttctct atcgataggt accgagctct     4920

tacgcgtgct agcccgggct cgag                                            4944


<210>  60
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Base pairs 201-320 of the C9orf72 gene (SEQ ID NO: 56)

<400>  60
ctctcacagt actcgctgag ggtgaacaag aaaagacctg ataaagatta accagaagaa       60

aacaaggagg gaaacaaccg cagcctgtag caagctctgg aactcaggag tcgcgcgcta      120


<210>  61
<211>  157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Base pairs 418-574 of the C9orf72 gene (SEQ ID NO: 56)

<400>  61
cgcaggcggt ggcgagtggg tgagtgagga ggcggcatcc tggcgggtgg ctgtttgggg       60

ttcggctgcc gggaagaggc gcgggtagaa gcgggggctc tcctcagagc tcgacgcatt      120

tttactttcc ctctcatttc tctgaccgaa gctgggt                               157


<210>  62
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hexanucleotide repeat (sense)

<400>  62
ggggcc                                                                   6


<210>  63
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hexanucleotide repeat (antisense)

<400>  63
ccccgg                                                                   6


<210>  64
<211>  959
<212>  PRT
<213>  Ruminococcus flavefaciens

<400>  64

Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr 
1               5                   10                  15      


Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser 
            20                  25                  30          


Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val 
        35                  40                  45              


Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly 
    50                  55                  60                  


Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Trp 
65                  70                  75                  80  


Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly 
                85                  90                  95      


Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly 
            100                 105                 110         


Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu 
        115                 120                 125             


Lys Ile Leu Ala Glu Tyr Ile Thr Asn Met Tyr Ala Val Asn Asn Ile 
    130                 135                 140                 


Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val 
145                 150                 155                 160 


Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe 
                165                 170                 175     


Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu 
            180                 185                 190         


Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala 
        195                 200                 205             


Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu 
    210                 215                 220                 


Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Ala His Trp Val Val 
225                 230                 235                 240 


Ala Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn 
                245                 250                 255     


Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu 
            260                 265                 270         


Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser 
        275                 280                 285             


Met Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu 
    290                 295                 300                 


Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn 
305                 310                 315                 320 


Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys 
                325                 330                 335     


Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg 
            340                 345                 350         


Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile 
        355                 360                 365             


Glu Glu Asp Ala Lys Val Ala Met Asn Lys Ser Leu Pro Asp Asn Glu 
    370                 375                 380                 


Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser 
385                 390                 395                 400 


Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg 
                405                 410                 415     


Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg 
            420                 425                 430         


Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro 
        435                 440                 445             


Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met 
    450                 455                 460                 


Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
465                 470                 475                 480 


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val 
                485                 490                 495     


Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe 
            500                 505                 510         


Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser 
        515                 520                 525             


Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr 
    530                 535                 540                 


Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu Ser Tyr Asp Glu Leu 
545                 550                 555                 560 


Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu Asn Gly Asn Lys Leu 
                565                 570                 575     


Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile Asn Asn Val Ile 
            580                 585                 590         


Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His 
        595                 600                 605             


Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly 
    610                 615                 620                 


Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln 
625                 630                 635                 640 


Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser 
                645                 650                 655     


Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn 
            660                 665                 670         


Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg 
        675                 680                 685             


Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu 
    690                 695                 700                 


Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg 
705                 710                 715                 720 


Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys 
                725                 730                 735     


Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe 
            740                 745                 750         


Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp 
        755                 760                 765             


Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser 
    770                 775                 780                 


Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile 
785                 790                 795                 800 


Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn 
                805                 810                 815     


Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys 
            820                 825                 830         


Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr 
        835                 840                 845             


Cys Thr Leu Phe Ala Asn Lys Ala Val Ala Leu Glu Val Ala Arg Tyr 
    850                 855                 860                 


Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln 
865                 870                 875                 880 


Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu 
                885                 890                 895     


Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu 
            900                 905                 910         


Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly 
        915                 920                 925             


Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asn Glu Met Lys Phe Asp Lys Glu Lys Lys Ser Gly Asn Ser 
945                 950                 955                 


<210>  65
<211>  1000
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example Cas13Rx polypeptide sequence

<400>  65

Met Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ile Glu Lys Lys 
1               5                   10                  15      


Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser Thr Leu Val Ser Gly 
            20                  25                  30          


Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly Ser Asp Ala Arg Leu 
        35                  40                  45              


Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser Val Asn Glu Gly Glu 
    50                  55                  60                  


Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala Gly Tyr Lys Ile Gly 
65                  70                  75                  80  


Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala Val Val Ala Asn Asn 
                85                  90                  95      


Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met Leu Gly Leu Lys Glu 
            100                 105                 110         


Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala Asp Gly Asn Asp Asn 
        115                 120                 125             


Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp Ile Glu Lys Ile Leu 
    130                 135                 140                 


Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val Asn Asn Ile Ser Gly 
145                 150                 155                 160 


Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe Ser Thr Val Tyr Thr 
                165                 170                 175     


Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg Ala Ala Phe Asn Asn 
            180                 185                 190         


Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln Tyr Asp Glu Phe Asp 
        195                 200                 205             


Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe Gly Gln Ala Phe Phe 
    210                 215                 220                 


Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr Gly Asn Glu Cys Tyr 
225                 230                 235                 240 


Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His Trp Val Val His Asn 
                245                 250                 255     


Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp Leu Tyr Asn Leu Asp 
            260                 265                 270         


Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu Asn Tyr Leu Tyr Asp 
        275                 280                 285             


Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser Lys Asn Ser Ala Ala 
    290                 295                 300                 


Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile Asn Pro Ala Glu Phe 
305                 310                 315                 320 


Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys Glu Gln Lys Asn Leu 
                325                 330                 335     


Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met Leu Asp Arg Lys Asp 
            340                 345                 350         


Met Ser Glu Ile Arg Lys Asn His Lys Val Phe Asp Ser Ile Arg Thr 
        355                 360                 365             


Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr Arg Tyr Tyr Ile Glu 
    370                 375                 380                 


Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser Leu Pro Asp Asn Glu 
385                 390                 395                 400 


Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile Asn Leu Arg Gly Ser 
                405                 410                 415     


Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr Asp Glu Ala Asn Arg 
            420                 425                 430         


Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn Ile Lys Glu Phe Arg 
        435                 440                 445             


Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp Ala Pro Arg Leu Pro 
    450                 455                 460                 


Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala Phe Ser Lys Leu Met 
465                 470                 475                 480 


Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
                485                 490                 495     


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln Ser Phe Leu Lys Val 
            500                 505                 510         


Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val Glu Glu Tyr Ala Phe 
        515                 520                 525             


Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu Arg Leu Ile Lys Ser 
    530                 535                 540                 


Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala Arg Arg Ala Met Tyr 
545                 550                 555                 560 


Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu Ser Tyr Asp Glu Leu 
                565                 570                 575     


Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu Asn Gly Asn Lys Leu 
            580                 585                 590         


Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile Ile Asn Asn Val Ile 
        595                 600                 605             


Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr Gly Asp Pro Ala His 
    610                 615                 620                 


Leu His Glu Ile Ala Lys Asn Glu Ala Val Val Lys Phe Val Leu Gly 
625                 630                 635                 640 


Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln Asn Gly Lys Asn Gln 
                645                 650                 655     


Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys Asp Lys Gly Lys Ser 
            660                 665                 670         


Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile Ile Thr Gly Met Asn 
        675                 680                 685             


Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile Glu Asp Thr Gly Arg 
    690                 695                 700                 


Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile Ile Ser Leu Tyr Leu 
705                 710                 715                 720 


Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val Asn Ile Asn Ala Arg 
                725                 730                 735     


Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp Ala Gln Leu Tyr Lys 
            740                 745                 750         


Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu Glu Glu Lys Gly Phe 
        755                 760                 765             


Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp Glu Thr Ala Pro Asp 
    770                 775                 780                 


Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu Arg Ala Lys Glu Ser 
785                 790                 795                 800 


Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu Tyr Ala Asn Tyr Ile 
                805                 810                 815     


Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe Thr Arg Gln Ile Asn 
            820                 825                 830         


Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr Leu Arg Asn Thr Lys 
        835                 840                 845             


Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg Ile Asp Asn Lys Thr 
    850                 855                 860                 


Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu Glu Val Ala Arg Tyr 
865                 870                 875                 880 


Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val Asn Ser Tyr Phe Gln 
                885                 890                 895     


Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met Asn Glu Arg Tyr Glu 
            900                 905                 910         


Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp Ala Val Asn Asp Glu 
        915                 920                 925             


Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu Cys Val Pro Phe Gly 
    930                 935                 940                 


Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Ala Leu Phe Asp 
945                 950                 955                 960 


Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys Lys Lys Val Ser Gly 
                965                 970                 975     


Asn Ser Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Tyr 
            980                 985                 990         


Pro Tyr Asp Val Pro Asp Tyr Ala  
        995                 1000 


<210>  66
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alternative hexanucleotide repeat (antisense)

<400>  66
ggcccc                                                                   6


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Repeat containing intron 1a Fwd primer

<400>  67
ccccactact tgctctcaca                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Repeat containing intron 1a Rev primer

<400>  68
cggttgtttc cctccttgtt                                                   20


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon 1b containing Fwd primer

<400>  69
gcggtggcga gtggatat                                                     18


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exon 1b containing Rev primer

<400>  70
tgggcaaaga gtcgacatca                                                   20


<210>  71
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense repeat transcript Fwd primer

<400>  71
agtcgctaga ggcgaaagc                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense repeat containing Rev primer

<400>  72
cgagtgggtg agtgaggag                                                    19


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH Fwd primer

<400>  73
gtctcctctg acttcaacag cg                                                22


<210>  74
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH Rev primer

<400>  74
accaccctgt tgctgtagcc aa                                                22


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  149R AAV repeats Fwd primer

<400>  75
agtactcgct gagggtgaac aag                                               23


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  149R AAV repeats Rev primer

<400>  76
agcttgctac aggctgcggt tg                                                22


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-targeting guide sequence

<400>  77
gtaatgcctg gcttgtcgac gcatagtctg                                        30


