                         SEQUENCE LISTING

<110>  OBLIQUE THERAPEUTICS AB
 
<120>  KRAS ANTIBODIES

<130>  15.69.154747/01

<140>  PCT/EP2022/060112
<141>  2022-04-14

<150>  US63/175,679
<151>  2021-04-16

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated G12D Ab1 and G12D Ab2 peptides, 
       not including additional modifications present for the purposes 
       of antibody generation

<400>  1

Gly Ala Asp Gly Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated G13D Ab1 and G13D Ab2 peptides, 
       not including additional modifications present for the purposes 
       of antibody generation

<400>  2

Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10          


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated G12D Ab1 peptide, including 
       additional modifications present for the purposes of antibody 
       generation


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  The peptide is amidated at the C-terminus, and is acetylated at 
       the N-terminus.

<400>  3

Gly Ala Asp Gly Val Gly Lys Ser Ala Leu Thr Ile Cys 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated G12D Ab2 peptide, including 
       additional modifications present for the purposes of antibody 
       generation


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  The peptide is amidated at the C-terminus.

<400>  4

Cys Gly Ala Asp Gly Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated G13D Ab1 peptide, including 
       additional modifications present for the purposes of antibody 
       generation


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  The peptide is amidated at the C-terminus.

<400>  5

Cys Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated G13D Ab2 peptide, including 
       additional modifications present for the purposes of antibody 
       generation


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  The peptide is amidated at the C-terminus, and is acetylated at 
       the N-terminus.

<400>  6

Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr Ile Cys 
1               5                   10              


<210>  7
<211>  189
<212>  PRT
<213>  Human

<400>  7

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  8
<211>  189
<212>  PRT
<213>  Human

<400>  8

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  9
<211>  189
<212>  PRT
<213>  Human

<400>  9

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  10
<211>  188
<212>  PRT
<213>  Human

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  11
<211>  188
<212>  PRT
<213>  Human

<400>  11

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  12
<211>  188
<212>  PRT
<213>  Human

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Asp Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated C-Ahx-GAG peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  An Ahx spacer is located between the C residue at the N-terminus 
       and the first glycine residue

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  The peptide is amidated at the C-terminus

<400>  13

Cys Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of isolated C-X-GAG peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  There is a spacer between the C residue at the N-terminus and the
       first glycine residue.

<400>  14

Cys Gly Ala Gly Asp Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10              


<210>  15
<211>  342
<212>  DNA
<213>  Mouse

<400>  15
caggtccacc tgcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cacctttact aggtactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtggtta tactgattac      180

aatcagaagt tcatggacaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctga gcagcctgac atatgaggac tctgcagtct atttctgtgc aagaggggtt      300

ggcggctact ggggccaagg caccgctctc acagtctcct ca                         342


<210>  16
<211>  318
<212>  DNA
<213>  Mouse

<400>  16
gaaaatgttc tcacccagtc tccaccaatc atgtctgcat ctccagggga aaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaagc      120

acctccccca aactctggat ttatgacaca tccaaactgg cttctggagt cccaggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcct cttattactg ttttcagggg agtgggtacc cactcacgtt cggtgctggg      300

accaagctgg cgctgaaa                                                    318


<210>  17
<211>  114
<212>  PRT
<213>  Mouse

<400>  17

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Gly Gly Tyr Trp Gly Gln Gly Thr Ala Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  18
<211>  106
<212>  PRT
<213>  Mouse

<400>  18

Glu Asn Val Leu Thr Gln Ser Pro Pro Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Ser Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Ala Leu Lys 
            100                 105     


<210>  19
<211>  5
<212>  PRT
<213>  Mouse

<400>  19

Arg Tyr Trp Met His 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Mouse

<400>  20

Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Asp Tyr Asn Gln Lys Phe Met 
1               5                   10                  15      


Asp 
    


<210>  21
<211>  5
<212>  PRT
<213>  Mouse

<400>  21

Gly Val Gly Gly Tyr 
1               5   


<210>  22
<211>  10
<212>  PRT
<213>  Mouse

<400>  22

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  23
<211>  7
<212>  PRT
<213>  Mouse

<400>  23

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Mouse

<400>  24

Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  25
<211>  30
<212>  PRT
<213>  Mouse

<400>  25

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  26
<211>  14
<212>  PRT
<213>  Mouse

<400>  26

Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  27
<211>  32
<212>  PRT
<213>  Mouse

<400>  27

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  Mouse

<400>  28

Trp Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  23
<212>  PRT
<213>  Mouse

<400>  29

Glu Asn Val Leu Thr Gln Ser Pro Pro Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys 
            20              


<210>  30
<211>  15
<212>  PRT
<213>  Mouse

<400>  30

Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
1               5                   10                  15  


<210>  31
<211>  32
<212>  PRT
<213>  Mouse

<400>  31

Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala Ser Tyr Tyr Cys 
            20                  25                  30          


<210>  32
<211>  10
<212>  PRT
<213>  Mouse

<400>  32

Phe Gly Ala Gly Thr Lys Leu Ala Leu Lys 
1               5                   10  


<210>  33
<211>  19
<212>  PRT
<213>  Mouse

<400>  33

Met Glu Arg His Trp Ile Phe Leu Ser Leu Leu Ser Val Ile Ala Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  34
<211>  22
<212>  PRT
<213>  Mouse

<400>  34

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  35
<211>  348
<212>  DNA
<213>  Mouse

<400>  35
caggttcagc tgcagcagtc tggagctgag gtggcgaggc ctggggcttc agtgaaactg       60

tcctgcaagg cttctggcta caccttcaca cgctatggta taaactgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttttccta gacgtgataa tacttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac      240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aacttatgat      300

tacgacgggg cttactgggg ccgagggact ctggtcactg tctctgca                   348


<210>  36
<211>  321
<212>  DNA
<213>  Mouse

<400>  36
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt gtttacttaa gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa      180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      240

gaagattttg cagactatta ctgtctacaa tatgttagtt atcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  37
<211>  116
<212>  PRT
<213>  Mouse

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Phe Pro Arg Arg Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Asp Tyr Asp Gly Ala Tyr Trp Gly Arg Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  38
<211>  107
<212>  PRT
<213>  Mouse

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Val Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Val Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  5
<212>  PRT
<213>  Mouse

<400>  39

Arg Tyr Gly Ile Asn 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Mouse

<400>  40

Glu Ile Phe Pro Arg Arg Asp Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  7
<212>  PRT
<213>  Mouse

<400>  41

Tyr Asp Tyr Asp Gly Ala Tyr 
1               5           


<210>  42
<211>  11
<212>  PRT
<213>  Mouse

<400>  42

Arg Ala Ser Gln Glu Ile Ser Val Tyr Leu Ser 
1               5                   10      


<210>  43
<211>  7
<212>  PRT
<213>  Mouse

<400>  43

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Mouse

<400>  44

Leu Gln Tyr Val Ser Tyr Pro Arg Thr 
1               5                   


<210>  45
<211>  30
<212>  PRT
<213>  Mouse

<400>  45

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  46
<211>  14
<212>  PRT
<213>  Mouse

<400>  46

Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  47
<211>  32
<212>  PRT
<213>  Mouse

<400>  47

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Thr 
            20                  25                  30          


<210>  48
<211>  11
<212>  PRT
<213>  Mouse

<400>  48

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  49
<211>  23
<212>  PRT
<213>  Mouse

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys 
            20              


<210>  50
<211>  15
<212>  PRT
<213>  Mouse

<400>  50

Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  51
<211>  32
<212>  PRT
<213>  Mouse

<400>  51

Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  52
<211>  10
<212>  PRT
<213>  Mouse

<400>  52

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  53
<211>  19
<212>  PRT
<213>  Mouse

<400>  53

Met Glu Trp Ile Trp Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  54
<211>  20
<212>  PRT
<213>  Mouse

<400>  54

Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  55
<211>  348
<212>  DNA
<213>  Mouse

<400>  55
caggttcagc tgcagcagtc tggagctgaa ctggcgaggc ctggggcttc actgaagctg       60

tcctgcaagg cttctggcta caccttcaca aactatggta taaactgggt gaagcagagt      120

actggacagg gccttgagtg gattggagag gtttttccta gacgtggtaa tacttactac      180

actgagaaat tcaaggccaa ggccacactg actgcagaca agtcctccaa cacagcgtac      240

atagagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aacttatgat      300

tacgacgggg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  56
<211>  321
<212>  DNA
<213>  Mouse

<400>  56
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt atttacttaa gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc gcatccactt tagattctgg tgtcccaaaa      180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      240

gaagattttg cagactatta ctgtctacaa tatgctagtt atcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  57
<211>  116
<212>  PRT
<213>  Mouse

<400>  57

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Ser Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Phe Pro Arg Arg Gly Asn Thr Tyr Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Ile Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Asp Tyr Asp Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  58
<211>  107
<212>  PRT
<213>  Mouse

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Ile Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  59
<211>  5
<212>  PRT
<213>  Mouse

<400>  59

Asn Tyr Gly Ile Asn 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  Mouse

<400>  60

Glu Val Phe Pro Arg Arg Gly Asn Thr Tyr Tyr Thr Glu Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  61
<211>  7
<212>  PRT
<213>  Mouse

<400>  61

Tyr Asp Tyr Asp Gly Ala Tyr 
1               5           


<210>  62
<211>  11
<212>  PRT
<213>  Mouse

<400>  62

Arg Ala Ser Gln Glu Ile Ser Ile Tyr Leu Ser 
1               5                   10      


<210>  63
<211>  7
<212>  PRT
<213>  Mouse

<400>  63

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Mouse

<400>  64

Leu Gln Tyr Ala Ser Tyr Pro Arg Thr 
1               5                   


<210>  65
<211>  30
<212>  PRT
<213>  Mouse

<400>  65

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  66
<211>  14
<212>  PRT
<213>  Mouse

<400>  66

Trp Val Lys Gln Ser Thr Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  67
<211>  32
<212>  PRT
<213>  Mouse

<400>  67

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Ile Glu 
1               5                   10                  15      


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Thr 
            20                  25                  30          


<210>  68
<211>  11
<212>  PRT
<213>  Mouse

<400>  68

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  69
<211>  23
<212>  PRT
<213>  Mouse

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys 
            20              


<210>  70
<211>  15
<212>  PRT
<213>  Mouse

<400>  70

Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  32
<212>  PRT
<213>  Mouse

<400>  71

Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  10
<212>  PRT
<213>  Mouse

<400>  72

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  73
<211>  19
<212>  PRT
<213>  Mouse

<400>  73

Met Glu Trp Ile Trp Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  74
<211>  20
<212>  PRT
<213>  Mouse

<400>  74

Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR1 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  75

Xaa Tyr Gly Ile Asn 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR1 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Asn or Arg

<400>  76

Xaa Tyr Gly Ile Asn 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR2 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  any amino acid

<400>  77

Glu Xaa Phe Pro Arg Arg Xaa Asn Thr Tyr Tyr Xaa Glu Lys Phe Lys 
1               5                   10                  15      


Xaa 
    


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR2 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Gly or Asp

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Ala or Gly

<400>  78

Glu Xaa Phe Pro Arg Arg Xaa Asn Thr Tyr Tyr Xaa Glu Lys Phe Lys 
1               5                   10                  15      


Xaa 
    


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light CDR1 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  any amino acid

<400>  79

Arg Ala Ser Gln Glu Ile Ser Xaa Tyr Leu Ser 
1               5                   10      


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light CDR1 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Ile or Val

<400>  80

Arg Ala Ser Gln Glu Ile Ser Xaa Tyr Leu Ser 
1               5                   10      


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light CDR3 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  any amino acid

<400>  81

Leu Gln Tyr Xaa Ser Tyr Pro Arg Thr 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light CDR3 Consensus Sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Ala or Val

<400>  82

Leu Gln Tyr Xaa Ser Tyr Pro Arg Thr 
1               5                   


