                         SEQUENCE LISTING

<110>  UNIVERSITY COLLEGE CORK NATIONAL UNIVERSITY OF IRELAND CORK
 
<120>  Treatment of cerebrovascular events and neurological disorders

<130>  P13759PC00

<150>  EP21168469.1
<151>  2021-04-14

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Thr Leu Ser Ala Pro Pro Cys Thr Gln Arg Ile Lys Trp Lys 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Leu Pro Thr 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Glu Pro Thr Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Thr Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Met Arg Asp Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Glu Ile Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ala Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Arg Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Gly Asp 
        115                 120                 125             


Asp Gly Thr Arg Gly Val Thr Gly Arg Phe Thr Phe Thr Leu His Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Thr Met Glu Ala Val Ser Leu Thr Cys Asp Pro Glu Thr Pro Asp Ala 
                165                 170                 175     


Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Ser 
            180                 185                 190         


Leu Lys Leu Ser Glu Thr Asn Arg Thr Leu Phe Leu Leu Gly Val Thr 
        195                 200                 205             


Lys Tyr Thr Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro 
225                 230                 235                 240 


Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp 
                245                 250                 255     


Val Leu Asn Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile 
            260                 265                 270         


Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Arg 
        275                 280                 285             


Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Ile Arg 
305                 310                 315                 320 


Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg 
                325                 330                 335     


Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Val Leu Tyr Leu 
            340                 345                 350         


Ser Cys Ser Ala Asp Ser Asn Pro Pro Ala Gln Tyr Ser Trp Thr Ile 
        355                 360                 365             


Asn Glu Lys Phe Gln Leu Pro Gly Gln Lys Leu Phe Ile Arg His Ile 
    370                 375                 380                 


Thr Thr Lys His Ser Gly Leu Tyr Val Cys Ser Val Arg Asn Ser Ala 
385                 390                 395                 400 


Thr Gly Lys Glu Ser Ser Lys Ser Met Thr Val Glu Val Ser Asp Trp 
                405                 410                 415     


Thr Val Pro 
            


<210>  2
<211>  1956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSG1-Fc ORF

<400>  2
atgggaaccc tctcagcccc tccctgcaca cagcgcatca aatggaaggg gctcctgctc       60

acagcatcac ttttaaactt ctggaacctg cccaccactg cccaagtcac gattgaagcc      120

gagccaacca aagtttccga ggggaaggat gttcttctac ttgtccacaa tttgccccag      180

aatcttaccg gctacatctg gtacaaaggg caaatgaggg acctctacca ttacattaca      240

tcatatgtag tagacggtga aataattata tatgggcctg catatagtgg acgagaaaca      300

gcatattcca atgcatccct gctgatccag aatgtcaccc gggaggacgc aggatcctac      360

accttacaca tcataaaggg agatgatggg actagaggag taactggacg tttcaccttc      420

accttacacc tggagactcc taagccctcc atctccagca gcaacttaaa tcccagggag      480

accatggagg ctgtgagctt aacctgtgac cctgagactc cagacgcaag ctacctgtgg      540

tggatgaatg gtcagagcct ccctatgact cacagcttga agctgtccga aaccaacagg      600

accctctttc tattgggtgt cacaaagtat actgcaggac cctatgaatg tgaaatacgg      660

aacccagtga gtgccagccg cagtgaccca gtcaccctga atctcctccc gaagctgccc      720

aagccctaca tcaccatcaa caacttaaac cccagggaga ataaggatgt cttaaacttc      780

acctgtgaac ctaagagtga gaactacacc tacatttggt ggctaaatgg tcagagcctc      840

ccggtcagtc ccagggtaaa gcgacccatt gaaaacagga tcctcattct acccagtgtc      900

acgagaaatg aaacaggacc ctatcaatgt gaaatacggg accgatatgg tggcatccgc      960

agtgacccag tcaccctgaa tgtcctctat ggtccagacc tccccagaat ttacccttca     1020

ttcacctatt accgttcagg agaagtcctc tacttgtcct gttctgcgga ctctaaccca     1080

ccggcacagt attcttggac aattaatgaa aagtttcagc taccaggaca aaagctcttt     1140

atccgccata ttactacaaa gcatagcggg ctctatgttt gctctgttcg taactcagcc     1200

actggcaagg aaagctccaa atccatgaca gtcgaagtct ctgactggac agttcccgag     1260

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1320

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctctacat cacccgggaa     1380

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1440

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1500

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1560

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1620

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1680

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1740

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1800

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1860

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgaa gttccactac     1920

acgcagaaga gcctctccct gtctccgggt aaatga                               1956


<210>  3
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified human Fc ORF

<400>  3
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcta catcacccgg      120

gaacctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gaagttccac      660

tacacgcaga agagcctctc cctgtctccg ggtaaatga                             699


