                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES 
       ALTERNATIVES
       UNIVERSITE GRENOBLE ALPES
 
<120>  NOVEL UNIVERSAL VACCINE PRESENTING SYSTEM

<130>  B381231PCT D40920

<150>  EP21305483.6
<151>  2021-04-12

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  544
<212>  PRT
<213>  Human adenovirus B serotype 3


<220>
<221>  MISC_FEATURE
<223>  ADE3 Penton base protein

<400>  1

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Val Thr Val Asn 
145                 150                 155                 160 


Asp Thr Tyr Asp His Lys Glu Asp Ile Leu Lys Tyr Glu Trp Phe Glu 
                165                 170                 175     


Phe Ile Leu Pro Glu Gly Asn Phe Ser Ala Thr Met Thr Ile Asp Leu 
            180                 185                 190         


Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Glu Ile Gly Arg Gln Asn 
        195                 200                 205             


Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe 
    210                 215                 220                 


Arg Leu Gly Trp Asp Pro Glu Thr Lys Leu Ile Met Pro Gly Val Tyr 
225                 230                 235                 240 


Thr Tyr Glu Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly 
                245                 250                 255     


Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys 
            260                 265                 270         


Arg His Pro Phe Gln Glu Gly Phe Lys Ile Met Tyr Glu Asp Leu Glu 
        275                 280                 285             


Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Thr Ala Tyr Glu Glu Ser 
    290                 295                 300                 


Lys Lys Asp Thr Thr Thr Glu Thr Thr Thr Leu Ala Val Ala Glu Glu 
305                 310                 315                 320 


Thr Ser Glu Asp Asp Asp Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu 
                325                 330                 335     


Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Val Lys Lys Glu Leu Lys 
            340                 345                 350         


Ile Gln Pro Leu Glu Lys Asp Ser Lys Ser Arg Ser Tyr Asn Val Leu 
        355                 360                 365             


Glu Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn 
    370                 375                 380                 


Tyr Gly Asn Pro Glu Lys Gly Ile Arg Ser Trp Thr Leu Leu Thr Thr 
385                 390                 395                 400 


Ser Asp Val Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp 
                405                 410                 415     


Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Asn Asn 
            420                 425                 430         


Tyr Pro Val Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe 
        435                 440                 445             


Tyr Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ala Thr Ser 
    450                 455                 460                 


Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg 
465                 470                 475                 480 


Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu 
                485                 490                 495     


Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 
            500                 505                 510         


Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr 
        515                 520                 525             


Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
    530                 535                 540                 


<210>  2
<211>  544
<212>  PRT
<213>  Human adenovirus B serotype 7


<220>
<221>  MISC_FEATURE
<223>  ADE7 Penton base protein

<400>  2

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Val Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly His Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Val Thr Val Asn 
145                 150                 155                 160 


Asp Thr Tyr Asp His Lys Glu Asp Ile Leu Lys Tyr Glu Trp Phe Glu 
                165                 170                 175     


Phe Ile Leu Pro Glu Gly Asn Phe Ser Ala Thr Met Thr Ile Asp Leu 
            180                 185                 190         


Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Glu Ile Gly Arg Gln Asn 
        195                 200                 205             


Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe 
    210                 215                 220                 


Arg Leu Gly Trp Asp Pro Glu Thr Lys Leu Ile Met Pro Gly Val Tyr 
225                 230                 235                 240 


Thr Tyr Glu Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly 
                245                 250                 255     


Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys 
            260                 265                 270         


Arg His Pro Phe Gln Glu Gly Phe Lys Ile Met Tyr Glu Asp Leu Glu 
        275                 280                 285             


Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Thr Ala Tyr Glu Glu Ser 
    290                 295                 300                 


Lys Lys Asp Thr Thr Thr Glu Thr Thr Thr Leu Ala Val Ala Glu Glu 
305                 310                 315                 320 


Thr Ser Glu Asp Asp Asn Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu 
                325                 330                 335     


Lys His Lys Arg Glu Ala Ala Ala Ala Glu Val Lys Lys Glu Leu Lys 
            340                 345                 350         


Ile Gln Pro Leu Glu Lys Asp Ser Lys Ser Arg Ser Tyr Asn Val Leu 
        355                 360                 365             


Glu Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn 
    370                 375                 380                 


Tyr Gly Asn Pro Lys Lys Gly Ile Arg Ser Trp Thr Leu Leu Thr Thr 
385                 390                 395                 400 


Ser Asp Val Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp 
                405                 410                 415     


Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Asn Asn 
            420                 425                 430         


Tyr Pro Val Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe 
        435                 440                 445             


Tyr Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ala Thr Ser 
    450                 455                 460                 


Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg 
465                 470                 475                 480 


Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu 
                485                 490                 495     


Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln 
            500                 505                 510         


Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr 
        515                 520                 525             


Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
    530                 535                 540                 


<210>  3
<211>  561
<212>  PRT
<213>  Human adenovirus 11

<400>  3

Met Arg Arg Val Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly Pro 
1               5                   10                  15      


Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Gln Ala Thr Ala Val 
            20                  25                  30          


Met Gln Ser Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala 
        35                  40                  45              


Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Gln 
    50                  55                  60                  


Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile 
65                  70                  75                  80  


Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val 
                85                  90                  95      


Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile 
            100                 105                 110         


Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met 
        115                 120                 125             


His Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe 
    130                 135                 140                 


Lys Ala Arg Val Met Val Ser Arg Lys Pro Pro Asp Gly Ala Ala Val 
145                 150                 155                 160 


Gly Asp Thr Tyr Asp His Lys Gln Asp Ile Leu Lys Tyr Glu Trp Phe 
                165                 170                 175     


Glu Phe Thr Leu Pro Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp 
            180                 185                 190         


Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Lys Val Gly Arg Gln 
        195                 200                 205             


Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn 
    210                 215                 220                 


Phe Lys Leu Gly Trp Asp Pro Glu Thr Lys Leu Ile Met Pro Gly Val 
225                 230                 235                 240 


Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys 
                245                 250                 255     


Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg 
            260                 265                 270         


Lys Lys Gln Pro Phe Gln Glu Gly Phe Lys Ile Leu Tyr Glu Asp Leu 
        275                 280                 285             


Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Asn 
    290                 295                 300                 


Ser Lys Lys Glu Gln Lys Ala Lys Ile Glu Ala Ala Thr Ala Ala Ala 
305                 310                 315                 320 


Glu Ala Lys Ala Asn Ile Val Ala Ser Asp Ser Thr Arg Val Ala Asn 
                325                 330                 335     


Ala Gly Glu Val Arg Gly Asp Asn Phe Ala Pro Thr Pro Val Pro Thr 
            340                 345                 350         


Ala Glu Ser Leu Leu Ala Asp Val Ser Glu Gly Thr Asp Val Lys Leu 
        355                 360                 365             


Thr Ile Gln Pro Val Glu Lys Asp Ser Lys Asn Arg Ser Tyr Asn Val 
    370                 375                 380                 


Leu Glu Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr 
385                 390                 395                 400 


Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr 
                405                 410                 415     


Thr Ser Asp Val Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro 
            420                 425                 430         


Asp Met Met Lys Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser 
        435                 440                 445             


Asn Tyr Pro Val Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser 
    450                 455                 460                 


Phe Tyr Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ser Thr 
465                 470                 475                 480 


Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile 
                485                 490                 495     


Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala 
            500                 505                 510         


Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val 
        515                 520                 525             


Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val 
    530                 535                 540                 


Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr 
545                 550                 555                 560 


Phe 
    


<210>  4
<211>  519
<212>  PRT
<213>  Human adenovirus D serotype 9


<220>
<221>  MISC_FEATURE
<223>  ADE9 Penton base protein

<400>  4

Met Arg Arg Ala Val Val Ser Ser Ser Pro Pro Pro Ser Tyr Glu Ser 
1               5                   10                  15      


Val Met Ala Gln Ala Thr Leu Glu Val Pro Phe Val Pro Pro Arg Tyr 
            20                  25                  30          


Met Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala 
        35                  40                  45              


Pro Gln Tyr Asp Thr Thr Arg Val Tyr Leu Val Asp Asn Lys Ser Ala 
    50                  55                  60                  


Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 
65                  70                  75                  80  


Thr Val Val Gln Asn Asn Asp Phe Thr Pro Ala Glu Ala Ser Thr Gln 
                85                  90                  95      


Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Asp Leu Lys Thr 
            100                 105                 110         


Ile Leu His Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Thr Ser 
        115                 120                 125             


Lys Phe Lys Ala Arg Val Met Val Ala Arg Lys His Pro Glu Gly Val 
    130                 135                 140                 


Val Glu Thr Asp Leu Ser Gln Asp Lys Leu Glu Tyr Glu Trp Phe Glu 
145                 150                 155                 160 


Phe Thr Leu Pro Glu Gly Asn Phe Ser Glu Thr Met Thr Ile Asp Leu 
                165                 170                 175     


Met Asn Asn Ala Ile Leu Glu Asn Tyr Leu Gln Val Gly Arg Gln Asn 
            180                 185                 190         


Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Ser Arg Asn Phe 
        195                 200                 205             


Lys Leu Gly Trp Asp Pro Val Thr Lys Leu Val Met Pro Gly Val Tyr 
    210                 215                 220                 


Thr Tyr Glu Ala Phe His Pro Asp Val Val Leu Leu Pro Gly Cys Gly 
225                 230                 235                 240 


Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys 
                245                 250                 255     


Lys Gln Pro Phe Gln Glu Gly Phe Arg Ile Met Tyr Glu Asp Leu Glu 
            260                 265                 270         


Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Pro Lys Tyr Leu Glu Ser 
        275                 280                 285             


Lys Lys Lys Val Glu Asp Glu Thr Lys Asn Ala Ala Ala Ala Thr Ala 
    290                 295                 300                 


Asp Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Pro Ala Gln Glu Thr 
305                 310                 315                 320 


Ala Ala Asp Lys Lys Val Glu Val Leu Pro Ile Glu Lys Asp Glu Ser 
                325                 330                 335     


Gly Arg Ser Tyr Asn Leu Ile Gln Gly Thr His Asp Thr Leu Tyr Arg 
            340                 345                 350         


Ser Trp Tyr Leu Ser Tyr Thr Tyr Gly Asp Pro Glu Lys Gly Val Gln 
        355                 360                 365             


Ser Trp Thr Leu Leu Thr Thr Pro Asp Val Thr Cys Gly Ala Glu Gln 
    370                 375                 380                 


Val Tyr Trp Ser Leu Pro Asp Leu Met Gln Asp Pro Val Thr Phe Arg 
385                 390                 395                 400 


Ser Thr Gln Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Met 
                405                 410                 415     


Pro Phe Arg Ala Lys Ser Phe Tyr Asn Asp Leu Ala Val Tyr Ser Gln 
            420                 425                 430         


Leu Ile Arg Ser Tyr Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro 
        435                 440                 445             


Asp Asn Gln Ile Leu Cys Arg Pro Pro Ala Pro Thr Ile Thr Thr Val 
    450                 455                 460                 


Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg 
465                 470                 475                 480 


Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg 
                485                 490                 495     


Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg 
            500                 505                 510         


Val Leu Ser Ser Arg Thr Phe 
        515                 


<210>  5
<211>  520
<212>  PRT
<213>  Human adenovirus D serotype 15


<220>
<221>  MISC_FEATURE
<223>  ADE15 Penton base protein

<400>  5

Met Arg Arg Ala Val Val Ser Ser Ser Pro Pro Pro Ser Tyr Glu Ser 
1               5                   10                  15      


Val Met Ala Gln Ala Thr Leu Glu Val Pro Phe Val Pro Pro Arg Tyr 
            20                  25                  30          


Met Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala 
        35                  40                  45              


Pro Gln Tyr Asp Thr Thr Arg Val Tyr Leu Val Asp Asn Lys Ser Ala 
    50                  55                  60                  


Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 
65                  70                  75                  80  


Thr Val Val Gln Asn Asn Asp Phe Thr Pro Ala Glu Ala Ser Thr Gln 
                85                  90                  95      


Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Asp Leu Lys Thr 
            100                 105                 110         


Ile Leu His Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Thr Ser 
        115                 120                 125             


Lys Phe Lys Ala Arg Val Met Val Ala Arg Lys His Pro Glu Asn Val 
    130                 135                 140                 


Ala Lys Glu Asp Leu Ser Gln Asp Ile Leu Glu Tyr Lys Trp Phe Glu 
145                 150                 155                 160 


Phe Thr Leu Pro Glu Gly Asn Phe Ser Glu Thr Met Thr Ile Asp Leu 
                165                 170                 175     


Met Asn Asn Ala Ile Leu Glu Asn Tyr Leu Gln Val Gly Arg Gln Asn 
            180                 185                 190         


Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Ser Arg Asn Phe 
        195                 200                 205             


Lys Leu Gly Trp Asp Pro Val Thr Lys Leu Val Met Pro Gly Val Tyr 
    210                 215                 220                 


Thr Tyr Glu Ala Phe His Pro Asp Val Val Leu Leu Pro Gly Cys Gly 
225                 230                 235                 240 


Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys 
                245                 250                 255     


Lys Gln Pro Phe Gln Glu Gly Phe Arg Ile Met Tyr Glu Asp Leu Glu 
            260                 265                 270         


Gly Gly Asn Ile Pro Ala Leu Leu Asp Thr Lys Lys Tyr Leu Asp Ser 
        275                 280                 285             


Lys Lys Glu Leu Glu Asp Ala Ala Lys Glu Ala Ala Lys Gln Gln Gly 
    290                 295                 300                 


Asp Gly Ala Val Thr Arg Gly Asp Thr His Leu Thr Val Ala Gln Glu 
305                 310                 315                 320 


Lys Ala Ala Gln Lys Glu Leu Val Ile Val Pro Ile Glu Lys Asp Glu 
                325                 330                 335     


Ser Asn Arg Ser Tyr Asn Leu Ile Lys Asp Thr His Asp Thr Leu Tyr 
            340                 345                 350         


Arg Ser Trp Tyr Leu Ser Tyr Thr Tyr Gly Asp Pro Glu Lys Gly Val 
        355                 360                 365             


Gln Ser Trp Thr Leu Leu Thr Thr Pro Asp Val Thr Cys Gly Ala Glu 
    370                 375                 380                 


Gln Val Tyr Trp Ser Leu Pro Asp Leu Met Gln Asp Pro Val Thr Phe 
385                 390                 395                 400 


Arg Ser Thr Gln Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu 
                405                 410                 415     


Met Pro Phe Arg Ala Lys Ser Phe Tyr Asn Asp Leu Ala Val Tyr Ser 
            420                 425                 430         


Gln Leu Ile Arg Ser Tyr Thr Ser Leu Thr His Val Phe Asn Arg Phe 
        435                 440                 445             


Pro Asp Asn Gln Ile Leu Cys Arg Pro Pro Ala Pro Thr Ile Thr Thr 
    450                 455                 460                 


Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu 
465                 470                 475                 480 


Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg 
                485                 490                 495     


Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro 
            500                 505                 510         


Arg Val Leu Ser Ser Arg Thr Phe 
        515                 520 


<210>  6
<211>  535
<212>  PRT
<213>  Human adenovirus E serotype 4


<220>
<221>  MISC_FEATURE
<223>  ADE4 Penton base protein

<400>  6

Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 
1               5                   10                  15      


Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 
            20                  25                  30          


Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 
        35                  40                  45              


Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 
    50                  55                  60                  


Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 
65                  70                  75                  80  


Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 
                85                  90                  95      


Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 
            100                 105                 110         


Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 
        115                 120                 125             


Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 
    130                 135                 140                 


Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Gly Asp Asp Tyr Asp 
145                 150                 155                 160 


Gly Ser Gln Asp Glu Leu Lys Tyr Glu Trp Val Glu Phe Glu Leu Pro 
                165                 170                 175     


Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala 
            180                 185                 190         


Ile Ile Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu 
        195                 200                 205             


Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp 
    210                 215                 220                 


Asp Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala 
225                 230                 235                 240 


Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr 
                245                 250                 255     


Glu Ser Arg Leu Ser Asn Met Leu Gly Ile Arg Lys Arg Gln Pro Phe 
            260                 265                 270         


Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Asp Gly Gly Asn Ile 
        275                 280                 285             


Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ser 
    290                 295                 300                 


Val Ala Ala Ser Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg 
305                 310                 315                 320 


Gly Asp Asn Phe Ala Ser Ala Ala Ala Val Ala Ala Ala Lys Ala Asp 
                325                 330                 335     


Glu Thr Glu Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys 
            340                 345                 350         


Asp Arg Ser Tyr Asn Val Leu Ser Asp Lys Lys Asn Thr Ala Tyr Arg 
        355                 360                 365             


Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp His Glu Lys Gly Val Arg 
    370                 375                 380                 


Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln 
385                 390                 395                 400 


Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg 
                405                 410                 415     


Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Met 
            420                 425                 430         


Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln 
        435                 440                 445             


Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro 
    450                 455                 460                 


Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val 
465                 470                 475                 480 


Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg 
                485                 490                 495     


Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg 
            500                 505                 510         


Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg 
        515                 520                 525             


Val Leu Ser Ser Arg Thr Phe 
    530                 535 


<210>  7
<211>  571
<212>  PRT
<213>  Human adenovirus C serotype 2


<220>
<221>  MISC_FEATURE
<223>  ADE2 Penton base protein

<400>  7

Met Gln Arg Ala Ala Met Tyr Glu Glu Gly Pro Pro Pro Ser Tyr Glu 
1               5                   10                  15      


Ser Val Val Ser Ala Ala Pro Val Ala Ala Ala Leu Gly Ser Pro Phe 
            20                  25                  30          


Asp Ala Pro Leu Asp Pro Pro Phe Val Pro Pro Arg Tyr Leu Arg Pro 
        35                  40                  45              


Thr Gly Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Phe 
    50                  55                  60                  


Asp Thr Thr Arg Val Tyr Leu Val Asp Asn Lys Ser Thr Asp Val Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Ile 
                85                  90                  95      


Gln Asn Asn Asp Tyr Ser Pro Gly Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Leu Asp Asp Arg Ser His Trp Gly Gly Asp Leu Lys Thr Ile Leu His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Phe Met Phe Thr Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Ser Leu Thr Lys Asp Lys Gln Val Glu 
145                 150                 155                 160 


Leu Lys Tyr Glu Trp Val Glu Phe Thr Leu Pro Glu Gly Asn Tyr Ser 
                165                 170                 175     


Glu Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Val Glu His Tyr 
            180                 185                 190         


Leu Lys Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 
        195                 200                 205             


Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Phe Asp Pro Val Thr Gly 
    210                 215                 220                 


Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 
225                 230                 235                 240 


Ile Leu Leu Pro Gly Cys Gly Val Asp Phe Thr His Ser Arg Leu Ser 
                245                 250                 255     


Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Arg 
            260                 265                 270         


Ile Thr Tyr Asp Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 
        275                 280                 285             


Val Asp Ala Tyr Gln Ala Ser Leu Lys Asp Asp Thr Glu Gln Gly Gly 
    290                 295                 300                 


Asp Gly Ala Gly Gly Gly Asn Asn Ser Gly Ser Gly Ala Glu Glu Asn 
305                 310                 315                 320 


Ser Asn Ala Ala Ala Ala Ala Met Gln Pro Val Glu Asp Met Asn Asp 
                325                 330                 335     


His Ala Ile Arg Gly Asp Thr Phe Ala Thr Arg Ala Glu Glu Lys Arg 
            340                 345                 350         


Ala Glu Ala Glu Ala Ala Ala Glu Ala Ala Ala Pro Ala Ala Gln Pro 
        355                 360                 365             


Glu Val Glu Lys Pro Gln Lys Lys Pro Val Ile Lys Pro Leu Thr Glu 
    370                 375                 380                 


Asp Ser Lys Lys Arg Ser Tyr Asn Leu Ile Ser Asn Asp Ser Thr Phe 
385                 390                 395                 400 


Thr Gln Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Gln 
                405                 410                 415     


Thr Gly Ile Arg Ser Trp Thr Leu Leu Cys Thr Pro Asp Val Thr Cys 
            420                 425                 430         


Gly Ser Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro 
        435                 440                 445             


Val Thr Phe Arg Ser Thr Ser Gln Ile Ser Asn Phe Pro Val Val Gly 
    450                 455                 460                 


Ala Glu Leu Leu Pro Val His Ser Lys Ser Phe Tyr Asn Asp Gln Ala 
465                 470                 475                 480 


Val Tyr Ser Gln Leu Ile Arg Gln Phe Thr Ser Leu Thr His Val Phe 
                485                 490                 495     


Asn Arg Phe Pro Glu Asn Gln Ile Leu Ala Arg Pro Pro Ala Pro Thr 
            500                 505                 510         


Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 
        515                 520                 525             


Leu Pro Leu Arg Asn Ser Ile Gly Gly Val Gln Arg Val Thr Ile Thr 
    530                 535                 540                 


Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile 
545                 550                 555                 560 


Val Ser Pro Arg Val Leu Ser Ser Arg Thr Phe 
                565                 570     


<210>  8
<211>  558
<212>  PRT
<213>  Human adenovirus 14


<220>
<221>  MISC_FEATURE
<223>  ADE14 Penton base protein

<400>  8

Met Arg Arg Val Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly Pro 
1               5                   10                  15      


Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Gln Ala Thr Ala Val 
            20                  25                  30          


Met Gln Ser Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala 
        35                  40                  45              


Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Gln 
    50                  55                  60                  


Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile 
65                  70                  75                  80  


Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val 
                85                  90                  95      


Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile 
            100                 105                 110         


Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met 
        115                 120                 125             


His Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Asn Phe 
    130                 135                 140                 


Lys Ala Arg Val Met Val Ser Arg Lys Pro Pro Glu Gly Ala Ala Val 
145                 150                 155                 160 


Gly Asp Thr Tyr Asp His Lys Gln Asp Ile Leu Glu Tyr Glu Trp Phe 
                165                 170                 175     


Glu Phe Thr Leu Pro Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp 
            180                 185                 190         


Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Lys Val Gly Arg Gln 
        195                 200                 205             


Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn 
    210                 215                 220                 


Phe Lys Leu Gly Trp Asp Pro Glu Thr Lys Leu Ile Met Pro Gly Val 
225                 230                 235                 240 


Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys 
                245                 250                 255     


Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg 
            260                 265                 270         


Lys Lys Gln Pro Phe Gln Glu Gly Phe Lys Ile Leu Tyr Glu Asp Leu 
        275                 280                 285             


Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Asn 
    290                 295                 300                 


Ser Lys Lys Glu Gln Lys Ala Lys Ile Glu Ala Ala Ala Glu Ala Lys 
305                 310                 315                 320 


Ala Asn Ile Val Ala Ser Asp Ser Thr Arg Val Ala Asn Ala Gly Glu 
                325                 330                 335     


Val Arg Gly Asp Asn Phe Ala Pro Thr Pro Val Pro Thr Ala Glu Ser 
            340                 345                 350         


Leu Leu Ala Asp Val Thr Gly Gly Thr Asn Val Lys Leu Thr Ile Gln 
        355                 360                 365             


Pro Val Glu Lys Asp Ser Lys Asn Arg Ser Tyr Asn Val Leu Glu Asp 
    370                 375                 380                 


Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn Tyr Gly 
385                 390                 395                 400 


Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 
                405                 410                 415     


Val Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 
            420                 425                 430         


Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 
        435                 440                 445             


Val Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe Tyr Asn 
    450                 455                 460                 


Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ser Thr Ser Leu Thr 
465                 470                 475                 480 


His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg Pro Pro 
                485                 490                 495     


Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 
            500                 505                 510         


His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 
        515                 520                 525             


Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 
    530                 535                 540                 


Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
545                 550                 555             


<210>  9
<211>  519
<212>  PRT
<213>  Human adenovirus D10


<220>
<221>  MISC_FEATURE
<223>  ADE10 Penton base protein

<400>  9

Met Arg Arg Ala Val Val Ser Ser Ser Pro Pro Pro Ser Tyr Glu Ser 
1               5                   10                  15      


Val Met Ala Gln Ala Thr Leu Glu Val Pro Phe Val Pro Pro Arg Tyr 
            20                  25                  30          


Met Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala 
        35                  40                  45              


Pro Gln Tyr Asp Thr Thr Arg Val Tyr Leu Val Asp Asn Lys Ser Ala 
    50                  55                  60                  


Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr 
65                  70                  75                  80  


Thr Val Val Gln Asn Asn Asp Phe Thr Pro Ala Glu Ala Ser Thr Gln 
                85                  90                  95      


Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Asp Leu Lys Thr 
            100                 105                 110         


Ile Leu His Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Thr Ser 
        115                 120                 125             


Lys Phe Lys Ala Arg Val Met Val Ala Arg Lys His Pro Glu Gly Val 
    130                 135                 140                 


Val Glu Thr Asp Leu Ser Gln Asp Lys Leu Glu Tyr Glu Trp Phe Glu 
145                 150                 155                 160 


Phe Thr Leu Pro Glu Gly Asn Phe Ser Glu Thr Met Thr Ile Asp Leu 
                165                 170                 175     


Met Asn Asn Ala Ile Leu Glu Asn Tyr Leu Gln Val Gly Arg Gln Asn 
            180                 185                 190         


Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Ser Arg Asn Phe 
        195                 200                 205             


Lys Leu Gly Trp Asp Pro Val Thr Lys Leu Val Met Pro Gly Val Tyr 
    210                 215                 220                 


Thr Tyr Glu Ala Phe His Pro Asp Val Val Leu Leu Pro Gly Cys Gly 
225                 230                 235                 240 


Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys 
                245                 250                 255     


Lys Gln Pro Phe Gln Glu Gly Phe Arg Ile Met Tyr Glu Asp Leu Glu 
            260                 265                 270         


Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Pro Lys Tyr Leu Glu Ser 
        275                 280                 285             


Lys Lys Lys Val Glu Asp Glu Thr Lys Asn Ala Ala Ala Ala Thr Ala 
    290                 295                 300                 


Asp Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Pro Ala Gln Glu Thr 
305                 310                 315                 320 


Ala Ala Asp Lys Lys Val Glu Val Leu Pro Ile Glu Lys Asp Glu Ser 
                325                 330                 335     


Gly Arg Ser Tyr Asn Leu Ile Gln Gly Thr His Asp Thr Leu Tyr Arg 
            340                 345                 350         


Ser Trp Tyr Leu Ser Tyr Thr Tyr Gly Asp Pro Glu Lys Gly Val Gln 
        355                 360                 365             


Ser Trp Thr Leu Leu Thr Thr Pro Asp Val Thr Cys Gly Ala Glu Gln 
    370                 375                 380                 


Val Tyr Trp Ser Leu Pro Asp Leu Met Gln Asp Pro Val Thr Phe Arg 
385                 390                 395                 400 


Ser Thr Gln Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Met 
                405                 410                 415     


Pro Phe Arg Ala Lys Ser Phe Tyr Asn Asp Leu Ala Val Tyr Ser Gln 
            420                 425                 430         


Leu Ile Arg Ser Tyr Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro 
        435                 440                 445             


Asp Asn Gln Ile Leu Cys Arg Pro Pro Ala Pro Thr Ile Thr Thr Val 
    450                 455                 460                 


Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg 
465                 470                 475                 480 


Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg 
                485                 490                 495     


Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg 
            500                 505                 510         


Val Leu Ser Ser Arg Thr Phe 
        515                 


<210>  10
<211>  555
<212>  PRT
<213>  Human adenovirus B serotype 16


<220>
<221>  MISC_FEATURE
<223>  ADE16 Penton base protein

<400>  10

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Gln Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Val Thr Val Asn 
145                 150                 155                 160 


Asp His Lys Asp Asp Ile Leu Lys Tyr Glu Trp Phe Glu Phe Thr Leu 
                165                 170                 175     


Pro Glu Gly Asn Phe Ser Ala Thr Met Thr Ile Asp Leu Met Asn Asn 
            180                 185                 190         


Ala Ile Ile Asp Asn Tyr Leu Lys Ile Gly Arg Gln Asn Gly Val Leu 
        195                 200                 205             


Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly 
    210                 215                 220                 


Trp Asp Pro Glu Thr Lys Leu Ile Met Pro Gly Val Tyr Thr Tyr Glu 
225                 230                 235                 240 


Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe 
                245                 250                 255     


Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg His Pro 
            260                 265                 270         


Phe Gln Glu Gly Phe Lys Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn 
        275                 280                 285             


Ile Pro Ala Leu Leu Asp Val Thr Ala Tyr Glu Glu Ser Lys Lys Asp 
    290                 295                 300                 


Thr Thr Thr Glu Thr Gly Glu Lys Ala Val Val Lys Thr Thr Thr Val 
305                 310                 315                 320 


Ala Val Ala Glu Glu Thr Ser Glu Asp Asp Asn Ile Thr Arg Gly Asp 
                325                 330                 335     


Thr Tyr Ile Thr Glu Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Leu 
            340                 345                 350         


Leu Leu Met Ser Glu Val Lys Lys Glu Leu Lys Ile Gln Pro Leu Glu 
        355                 360                 365             


Lys Asp Ser Lys Asn Arg Ser Tyr Asn Val Leu Glu Asp Lys Ile Asn 
    370                 375                 380                 


Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn Tyr Gly Asn Pro Glu 
385                 390                 395                 400 


Lys Gly Ile Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys 
                405                 410                 415     


Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro 
            420                 425                 430         


Ile Thr Phe Arg Ser Ser Arg Gln Val Asn Asn Tyr Pro Val Val Gly 
        435                 440                 445             


Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe Tyr Asn Glu Gln Ala 
    450                 455                 460                 


Val Tyr Ser Gln Gln Leu Arg Gln Ser Thr Ser Leu Thr His Val Phe 
465                 470                 475                 480 


Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg Pro Pro Ala Pro Thr 
                485                 490                 495     


Ile Thr Thr Ile Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 
            500                 505                 510         


Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr 
        515                 520                 525             


Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile 
    530                 535                 540                 


Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
545                 550                 555 


<210>  11
<211>  559
<212>  PRT
<213>  Artificial

<220>
<223>  Addomer penton base protein including restriction sites

<400>  11

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Glu Phe Val Thr 
145                 150                 155                 160 


Val Asn Asp Gly Pro Val Asn Asp Thr Tyr Asp His Lys Glu Asp Ile 
                165                 170                 175     


Leu Lys Tyr Glu Trp Phe Glu Phe Ile Leu Pro Glu Gly Asn Phe Ser 
            180                 185                 190         


Ala Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 
        195                 200                 205             


Leu Glu Ile Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 
    210                 215                 220                 


Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Glu Thr Lys 
225                 230                 235                 240 


Leu Ile Met Pro Gly Val Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile 
                245                 250                 255     


Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 
            260                 265                 270         


Asn Leu Leu Gly Ile Arg Lys Arg His Pro Phe Gln Glu Gly Phe Lys 
        275                 280                 285             


Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 
    290                 295                 300                 


Val Thr Ala Tyr Glu Glu Ser Lys Lys Asp Thr Thr Thr Ala Arg Glu 
305                 310                 315                 320 


Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Val Asp Asp 
                325                 330                 335     


Asp Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Leu Glu Lys Gln Lys 
            340                 345                 350         


Arg Glu Ala Ala Ala Ala Glu Val Ser Arg Lys Lys Glu Leu Lys Ile 
        355                 360                 365             


Gln Pro Leu Glu Lys Asp Ser Lys Ser Arg Ser Tyr Asn Val Leu Glu 
    370                 375                 380                 


Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn Tyr 
385                 390                 395                 400 


Gly Asn Pro Glu Lys Gly Ile Arg Ser Trp Thr Leu Leu Thr Thr Ser 
                405                 410                 415     


Asp Val Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp Met 
            420                 425                 430         


Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Asn Asn Tyr 
        435                 440                 445             


Pro Val Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe Tyr 
    450                 455                 460                 


Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ala Thr Ser Leu 
465                 470                 475                 480 


Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg Pro 
                485                 490                 495     


Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr 
            500                 505                 510         


Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg 
        515                 520                 525             


Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys 
    530                 535                 540                 


Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
545                 550                 555                 


<210>  12
<211>  1683
<212>  DNA
<213>  Artificial

<220>
<223>  Addomer penton base protein including restriction sites

<400>  12
atgaggagac gagccgtgct aggcggagcg gtggtgtatc cggagggtcc tcctccttct       60

tacgagagcg tgatgcagca acaggcggcg atgatacagc ccccactgga ggctcccttc      120

gtacccccac ggtacctggc gcctacggaa gggagaaaca gcattcgtta ctcggagctg      180

tcgcccctgt acgataccac caagttgtat ctggtggaca acaagtcggc ggacatcgcc      240

tccctgaact atcagaacga ccacagcaac ttcctgacca cggtggtgca gaacaatgac      300

tttaccccca cggaggctag cacccagacc atcaactttg acgagcggtc gcgatggggc      360

ggtcagctga agaccatcat gcacaccaac atgcccaacg tgaacgagta catgttcagc      420

aacaagttca aggcgagggt gatggtgtcc agaaaagctc ctgaaggtga attcgtcaca      480

gtcaacgacg gtccggtcaa tgacacctat gatcataaag aggatatctt gaagtatgag      540

tggtttgagt tcattttacc agaaggcaac ttttcagcca ccatgacgat cgacctgatg      600

aacaatgcca tcattgacaa ctacctggaa attggcagac agaatggagt gctggaaagt      660

gacattggtg ttaagtttga cactagaaat ttcaggctcg ggtgggaccc cgaaactaag      720

ttgattatgc caggtgtcta cacttatgag gcattccatc ctgacattgt attgctgcct      780

ggttgcgggg tagactttac tgaaagccga cttagcaact tgcttggcat caggaagaga      840

catccattcc aggagggttt caaaatcatg tatgaagatc ttgaaggggg taatattcct      900

gcccttttgg atgtcactgc ctatgaggaa agcaaaaagg ataccactac tgcgcgcgaa      960

acaaccacac tggctgttgc agaggaaact agtgaagatg tcgacgatga tataactaga     1020

ggagatacct atataactga gctcgaaaaa caaaaacgtg aagctgctgc tgctgaagtt     1080

tctagaaaaa aagagttaaa gatccaacct ctggaaaaag acagcaagag tagaagctac     1140

aatgtcttgg aagacaaaat caacacagcc taccgcagtt ggtatctgtc ctacaattac     1200

ggtaaccctg agaaaggaat aaggtcttgg acactgctca ccacttcaga tgtcacctgt     1260

ggggcagagc aggtctactg gtcgctccct gacatgatgc aagacccagt caccttccgc     1320

tccacaagac aagtcaacaa ctacccagtg gtgggtgcag agcttatgcc cgtcttctca     1380

aagagtttct acaatgagca agccgtgtac tctcagcagc tccgacaggc cacttcgctc     1440

acgcacgtct tcaaccgctt ccctgagaac cagatcctca tccgcccgcc ggcacccaca     1500

attaccaccg tcagtgaaaa cgttcctgct ctcacagatc acgggaccct gccgttacgc     1560

agcagtatcc ggggagtcca gcgcgtgacc gttactgacg ccagacgccg cacctgtccc     1620

tacgtttaca aggccctggg catagtcgcg ccgcgcgttc tttcaagccg cactttctga     1680

taa                                                                   1683


<210>  13
<211>  574
<212>  PRT
<213>  Artificial

<220>
<223>  Addomer penton base protein with SpyTag in Variable loop (ADD-ST 
       V loop)

<400>  13

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Glu Phe Gly Ser 
145                 150                 155                 160 


Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Ser 
                165                 170                 175     


Gly Gly Gly Pro Val Asn Asp Thr Tyr Asp His Lys Glu Asp Ile Leu 
            180                 185                 190         


Lys Tyr Glu Trp Phe Glu Phe Ile Leu Pro Glu Gly Asn Phe Ser Ala 
        195                 200                 205             


Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu 
    210                 215                 220                 


Glu Ile Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys 
225                 230                 235                 240 


Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Glu Thr Lys Leu 
                245                 250                 255     


Ile Met Pro Gly Val Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile Val 
            260                 265                 270         


Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn 
        275                 280                 285             


Leu Leu Gly Ile Arg Lys Arg His Pro Phe Gln Glu Gly Phe Lys Ile 
    290                 295                 300                 


Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val 
305                 310                 315                 320 


Thr Ala Tyr Glu Glu Ser Lys Lys Asp Thr Thr Thr Ala Arg Glu Thr 
                325                 330                 335     


Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Val Asp Asp Asp 
            340                 345                 350         


Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Leu Glu Lys Gln Lys Arg 
        355                 360                 365             


Glu Ala Ala Ala Ala Glu Val Ser Arg Lys Lys Glu Leu Lys Ile Gln 
    370                 375                 380                 


Pro Leu Glu Lys Asp Ser Lys Ser Arg Ser Tyr Asn Val Leu Glu Asp 
385                 390                 395                 400 


Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn Tyr Gly 
                405                 410                 415     


Asn Pro Glu Lys Gly Ile Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 
            420                 425                 430         


Val Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 
        435                 440                 445             


Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Asn Asn Tyr Pro 
    450                 455                 460                 


Val Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe Tyr Asn 
465                 470                 475                 480 


Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ala Thr Ser Leu Thr 
                485                 490                 495     


His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg Pro Pro 
            500                 505                 510         


Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 
        515                 520                 525             


His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 
    530                 535                 540                 


Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 
545                 550                 555                 560 


Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
                565                 570                 


<210>  14
<211>  1728
<212>  DNA
<213>  Artificial

<220>
<223>  Addomer penton base protein with SpyTag in Variable loop (ADD-ST 
       V loop)

<400>  14
atgaggagac gagccgtgct aggcggagcg gtggtgtatc cggagggtcc tcctccttct       60

tacgagagcg tgatgcagca acaggcggcg atgatacagc ccccactgga ggctcccttc      120

gtacccccac ggtacctggc gcctacggaa gggagaaaca gcattcgtta ctcggagctg      180

tcgcccctgt acgataccac caagttgtat ctggtggaca acaagtcggc ggacatcgcc      240

tccctgaact atcagaacga ccacagcaac ttcctgacca cggtggtgca gaacaatgac      300

tttaccccca cggaggctag cacccagacc atcaactttg acgagcggtc gcgatggggc      360

ggtcagctga agaccatcat gcacaccaac atgcccaacg tgaacgagta catgttcagc      420

aacaagttca aggcgagggt gatggtgtcc agaaaagctc ctgaaggtga attcggttct      480

ggtgctcaca tcgtgatggt cgacgcctac aagcctacca agggctccgg tggcggtccg      540

gtcaatgaca cctatgatca taaagaggat atcttgaagt atgagtggtt tgagttcatt      600

ttaccagaag gcaacttttc agccaccatg acgatcgacc tgatgaacaa tgccatcatt      660

gacaactacc tggaaattgg cagacagaat ggagtgctgg aaagtgacat tggtgttaag      720

tttgacacta gaaatttcag gctcgggtgg gaccccgaaa ctaagttgat tatgccaggt      780

gtctacactt atgaggcatt ccatcctgac attgtattgc tgcctggttg cggggtagac      840

tttactgaaa gccgacttag caacttgctt ggcatcagga agagacatcc attccaggag      900

ggtttcaaaa tcatgtatga agatcttgaa gggggtaata ttcctgccct tttggatgtc      960

actgcctatg aggaaagcaa aaaggatacc actactgcgc gcgaaacaac cacactggct     1020

gttgcagagg aaactagtga agatgtcgac gatgatataa ctagaggaga tacctatata     1080

actgagctcg aaaaacaaaa acgtgaagct gctgctgctg aagtttctag aaaaaaagag     1140

ttaaagatcc aacctctgga aaaagacagc aagagtagaa gctacaatgt cttggaagac     1200

aaaatcaaca cagcctaccg cagttggtat ctgtcctaca attacggtaa ccctgagaaa     1260

ggaataaggt cttggacact gctcaccact tcagatgtca cctgtggggc agagcaggtc     1320

tactggtcgc tccctgacat gatgcaagac ccagtcacct tccgctccac aagacaagtc     1380

aacaactacc cagtggtggg tgcagagctt atgcccgtct tctcaaagag tttctacaat     1440

gagcaagccg tgtactctca gcagctccga caggccactt cgctcacgca cgtcttcaac     1500

cgcttccctg agaaccagat cctcatccgc ccgccggcac ccacaattac caccgtcagt     1560

gaaaacgttc ctgctctcac agatcacggg accctgccgt tacgcagcag tatccgggga     1620

gtccagcgcg tgaccgttac tgacgccaga cgccgcacct gtccctacgt ttacaaggcc     1680

ctgggcatag tcgcgccgcg cgttctttca agccgcactt tctgataa                  1728


<210>  15
<211>  567
<212>  PRT
<213>  Artificial

<220>
<223>   Addomer penton base protein with SpyTag  in RGD loop (ADD-ST RGD
       loop)

<400>  15

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Glu Phe Val Thr 
145                 150                 155                 160 


Val Asn Asp Gly Pro Val Asn Asp Thr Tyr Asp His Lys Glu Asp Ile 
                165                 170                 175     


Leu Lys Tyr Glu Trp Phe Glu Phe Ile Leu Pro Glu Gly Asn Phe Ser 
            180                 185                 190         


Ala Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 
        195                 200                 205             


Leu Glu Ile Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 
    210                 215                 220                 


Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Glu Thr Lys 
225                 230                 235                 240 


Leu Ile Met Pro Gly Val Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile 
                245                 250                 255     


Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 
            260                 265                 270         


Asn Leu Leu Gly Ile Arg Lys Arg His Pro Phe Gln Glu Gly Phe Lys 
        275                 280                 285             


Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 
    290                 295                 300                 


Val Thr Ala Tyr Glu Glu Ser Lys Lys Asp Thr Thr Thr Ala Arg Glu 
305                 310                 315                 320 


Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Val Asp Gly 
                325                 330                 335     


Ser Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly 
            340                 345                 350         


Ser Gly Glu Leu Glu Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Val 
        355                 360                 365             


Ser Arg Lys Lys Glu Leu Lys Ile Gln Pro Leu Glu Lys Asp Ser Lys 
    370                 375                 380                 


Ser Arg Ser Tyr Asn Val Leu Glu Asp Lys Ile Asn Thr Ala Tyr Arg 
385                 390                 395                 400 


Ser Trp Tyr Leu Ser Tyr Asn Tyr Gly Asn Pro Glu Lys Gly Ile Arg 
                405                 410                 415     


Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Ala Glu Gln 
            420                 425                 430         


Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg 
        435                 440                 445             


Ser Thr Arg Gln Val Asn Asn Tyr Pro Val Val Gly Ala Glu Leu Met 
    450                 455                 460                 


Pro Val Phe Ser Lys Ser Phe Tyr Asn Glu Gln Ala Val Tyr Ser Gln 
465                 470                 475                 480 


Gln Leu Arg Gln Ala Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro 
                485                 490                 495     


Glu Asn Gln Ile Leu Ile Arg Pro Pro Ala Pro Thr Ile Thr Thr Val 
            500                 505                 510         


Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg 
        515                 520                 525             


Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg 
    530                 535                 540                 


Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg 
545                 550                 555                 560 


Val Leu Ser Ser Arg Thr Phe 
                565         


<210>  16
<211>  1707
<212>  DNA
<213>  Artificial

<220>
<223>  Addomer penton base protein with SpyTag  in RGD loop (ADD-ST RGD 
       loop)

<400>  16
atgaggagac gagccgtgct aggcggagcg gtggtgtatc cggagggtcc tcctccttct       60

tacgagagcg tgatgcagca acaggcggcg atgatacagc ccccactgga ggctcccttc      120

gtacccccac ggtacctggc gcctacggaa gggagaaaca gcattcgtta ctcggagctg      180

tcgcccctgt acgataccac caagttgtat ctggtggaca acaagtcggc ggacatcgcc      240

tccctgaact atcagaacga ccacagcaac ttcctgacca cggtggtgca gaacaatgac      300

tttaccccca cggaggctag cacccagacc atcaactttg acgagcggtc gcgatggggc      360

ggtcagctga agaccatcat gcacaccaac atgcccaacg tgaacgagta catgttcagc      420

aacaagttca aggcgagggt gatggtgtcc agaaaagctc ctgaaggtga attcgtcaca      480

gtcaacgacg gtccggtcaa tgacacctat gatcataaag aggatatctt gaagtatgag      540

tggtttgagt tcattttacc agaaggcaac ttttcagcca ccatgacgat cgacctgatg      600

aacaatgcca tcattgacaa ctacctggaa attggcagac agaatggagt gctggaaagt      660

gacattggtg ttaagtttga cactagaaat ttcaggctcg ggtgggaccc cgaaactaag      720

ttgattatgc caggtgtcta cacttatgag gcattccatc ctgacattgt attgctgcct      780

ggttgcgggg tagactttac tgaaagccga cttagcaact tgcttggcat caggaagaga      840

catccattcc aggagggttt caaaatcatg tatgaagatc ttgaaggggg taatattcct      900

gcccttttgg atgtcactgc ctatgaggaa agcaaaaagg ataccactac tgcgcgcgaa      960

acaaccacac tggctgttgc agaggaaact agtgaagatg tcgacggttc cggtgctcac     1020

atcgtgatgg tggacgccta caagcctacc aagggctccg gtgagctcga aaaacaaaaa     1080

cgtgaagctg ctgctgctga agtttctaga aaaaaagagt taaagatcca acctctggaa     1140

aaagacagca agagtagaag ctacaatgtc ttggaagaca aaatcaacac agcctaccgc     1200

agttggtatc tgtcctacaa ttacggtaac cctgagaaag gaataaggtc ttggacactg     1260

ctcaccactt cagatgtcac ctgtggggca gagcaggtct actggtcgct ccctgacatg     1320

atgcaagacc cagtcacctt ccgctccaca agacaagtca acaactaccc agtggtgggt     1380

gcagagctta tgcccgtctt ctcaaagagt ttctacaatg agcaagccgt gtactctcag     1440

cagctccgac aggccacttc gctcacgcac gtcttcaacc gcttccctga gaaccagatc     1500

ctcatccgcc cgccggcacc cacaattacc accgtcagtg aaaacgttcc tgctctcaca     1560

gatcacggga ccctgccgtt acgcagcagt atccggggag tccagcgcgt gaccgttact     1620

gacgccagac gccgcacctg tccctacgtt tacaaggccc tgggcatagt cgcgccgcgc     1680

gttctttcaa gccgcacttt ctgataa                                         1707


<210>  17
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE3

<400>  17

Thr Glu Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Asp 
1               5                   10                  15      


Asp Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Lys Gln Lys Arg Glu 
            20                  25                  30          


Ala Ala Ala Ala Glu Val Lys Lys 
        35                  40  


<210>  18
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE7

<400>  18

Thr Glu Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Asp 
1               5                   10                  15      


Asn Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Lys His Lys Arg Glu 
            20                  25                  30          


Ala Ala Ala Ala Glu Val Lys Lys 
        35                  40  


<210>  19
<211>  56
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE11

<400>  19

Ala Lys Ile Glu Ala Ala Thr Ala Ala Ala Glu Ala Lys Ala Asn Ile 
1               5                   10                  15      


Val Ala Ser Asp Ser Thr Arg Val Ala Asn Ala Gly Glu Val Arg Gly 
            20                  25                  30          


Asp Asn Phe Ala Pro Thr Pro Val Pro Thr Ala Glu Ser Leu Leu Ala 
        35                  40                  45              


Asp Val Ser Glu Gly Thr Asp Val 
    50                  55      


<210>  20
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE9

<400>  20

Asp Glu Thr Lys Asn Ala Ala Ala Ala Thr Ala Asp Thr Thr Thr Arg 
1               5                   10                  15      


Gly Asp Thr Phe Ala Thr Pro Ala Gln Glu Thr Ala Ala Asp Lys 
            20                  25                  30      


<210>  21
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE15

<400>  21

Asp Ala Ala Lys Glu Ala Ala Lys Gln Gln Gly Asp Gly Ala Val Thr 
1               5                   10                  15      


Arg Gly Asp Thr His Leu Thr Val Ala Gln Glu Lys Ala Ala Gln Lys 
            20                  25                  30          


<210>  22
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE4

<400>  22

Ala Ala Ser Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly 
1               5                   10                  15      


Asp Asn Phe Ala Ser Ala Ala Ala Val Ala Ala Ala Lys Ala Asp Glu 
            20                  25                  30          


Thr Glu Ser 
        35  


<210>  23
<211>  75
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE02

<400>  23

Glu Gln Gly Gly Asp Gly Ala Gly Gly Gly Asn Asn Ser Gly Ser Gly 
1               5                   10                  15      


Ala Glu Glu Asn Ser Asn Ala Ala Ala Ala Ala Met Gln Pro Val Glu 
            20                  25                  30          


Asp Met Asn Asp His Ala Ile Arg Gly Asp Thr Phe Ala Thr Arg Ala 
        35                  40                  45              


Glu Glu Lys Arg Ala Glu Ala Glu Ala Ala Ala Glu Ala Ala Ala Pro 
    50                  55                  60                  


Ala Ala Gln Pro Glu Val Glu Lys Pro Gln Lys 
65                  70                  75  


<210>  24
<211>  53
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE 14

<400>  24

Ala Lys Ile Glu Ala Ala Ala Glu Ala Lys Ala Asn Ile Val Ala Ser 
1               5                   10                  15      


Asp Ser Thr Arg Val Ala Asn Ala Gly Glu Val Arg Gly Asp Asn Phe 
            20                  25                  30          


Ala Pro Thr Pro Val Pro Thr Ala Glu Ser Leu Leu Ala Asp Val Thr 
        35                  40                  45              


Gly Gly Thr Asn Val 
    50              


<210>  25
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE10

<400>  25

Asp Glu Thr Lys Asn Ala Ala Ala Ala Thr Ala Asp Thr Thr Thr Arg 
1               5                   10                  15      


Gly Asp Thr Phe Ala Thr Pro Ala Gln Glu Thr Ala Ala Asp Lys 
            20                  25                  30      


<210>  26
<211>  54
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop ADE16

<400>  26

Thr Glu Thr Gly Glu Lys Ala Val Val Lys Thr Thr Thr Val Ala Val 
1               5                   10                  15      


Ala Glu Glu Thr Ser Glu Asp Asp Asn Ile Thr Arg Gly Asp Thr Tyr 
            20                  25                  30          


Ile Thr Glu Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Leu Leu Leu 
        35                  40                  45              


Met Ser Glu Val Lys Lys 
    50                  


<210>  27
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  RGD loop Addomer Penton base protein of SEQ ID NO: 11

<400>  27

Thr Ala Arg Glu Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu 
1               5                   10                  15      


Asp Val Asp Asp Asp Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Leu 
            20                  25                  30          


Glu Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Val Ser Arg Lys Lys 
        35                  40                  45              


<210>  28
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE3 Penton base protein

<400>  28

Ser Arg Lys Ala Pro Glu Gly Val Thr Val Asn Asp Thr Tyr Asp His 
1               5                   10                  15      


Lys Glu Asp Ile 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE7 Penton base protein

<400>  29

Ser Arg Lys Ala Pro Glu Gly Val Thr Val Asn Asp Thr Tyr Asp His 
1               5                   10                  15      


Lys Glu Asp Ile 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE11 Penton base protein

<400>  30

Ser Arg Lys Pro Pro Asp Gly Ala Ala Val Gly Asp Thr Tyr Asp His 
1               5                   10                  15      


Lys Gln Asp Ile 
            20  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE9 Penton base protein

<400>  31

Ala Arg Lys His Pro Glu Gly Val Val Glu Thr Asp Leu Ser Gln Asp 
1               5                   10                  15      


Lys 
    


<210>  32
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE15 Penton base protein

<400>  32

Ala Arg Lys His Pro Glu Asn Val Ala Lys Glu Asp Leu Ser Gln Asp 
1               5                   10                  15      


Ile 
    


<210>  33
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE4 Penton base protein

<400>  33

Ser Arg Lys Thr Pro Asn Gly Val Thr Val Gly Asp Asp Tyr Asp Gly 
1               5                   10                  15      


Ser Gln Asp Glu 
            20  


<210>  34
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE2 Penton base protein

<400>  34

Ser Arg Ser Leu Thr Lys Asp Lys Gln Val Glu 
1               5                   10      


<210>  35
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE14 Penton base protein

<400>  35

Ser Arg Lys Pro Pro Glu Gly Ala Ala Val Gly Asp Thr Tyr Asp His 
1               5                   10                  15      


Lys Gln Asp Ile 
            20  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE10 Penton base protein

<400>  36

Ala Arg Lys His Pro Glu Gly Val Val Glu Thr Asp Leu Ser Gln Asp 
1               5                   10                  15      


Lys 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  V loop ADE16 Penton base protein

<400>  37

Ser Arg Lys Ala Pro Glu Gly Val Thr Val Asn Asp His Lys Asp Asp 
1               5                   10                  15      


Ile 
    


<210>  38
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  V loop Addomer Penton base protein of SEQ ID NO :11

<400>  38

Ser Arg Lys Ala Pro Glu Gly Glu Phe Val Thr Val Asn Asp Gly Pro 
1               5                   10                  15      


Val Asn Asp Thr Tyr Asp His Lys Glu Asp Ile 
            20                  25          


<210>  39
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  IsopepTag

<400>  39

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  40
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  SpyTag

<400>  40

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  41
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  SpyTag002

<400>  41

Val Pro Thr Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
1               5                   10                  


<210>  42
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  SpyTag003

<400>  42

Arg Gly Val Pro His Ile Val Met Val Asp Ala Tyr Lys Arg Tyr Lys 
1               5                   10                  15      


<210>  43
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  SnoopTag

<400>  43

Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  SnoopTagJr

<400>  44

Lys Leu Gly Ser Ile Glu Phe Ile Lys Val Asn Lys 
1               5                   10          


<210>  45
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Dog Tag

<400>  45

Asp Ile Pro Ala Thr Tyr Glu Phe Thr Asp Gly Lys His Tyr Ile Thr 
1               5                   10                  15      


Asn Glu Pro Ile Pro Pro Lys 
            20              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Sdy Tag

<400>  46

Asp Pro Ile Val Met Ile Asp Asn Asp Lys Pro Ile Thr 
1               5                   10              


<210>  47
<211>  340
<212>  PRT
<213>  Streptococcus pyogenes


<220>
<221>  MISC_FEATURE
<223>  Pilin C protein

<400>  47

Met Lys Leu Arg His Leu Leu Leu Thr Gly Ala Ala Leu Thr Ser Phe 
1               5                   10                  15      


Ala Ala Thr Thr Val His Gly Glu Thr Val Val Asn Gly Ala Lys Leu 
            20                  25                  30          


Thr Val Thr Lys Asn Leu Asp Leu Val Asn Ser Asn Ala Leu Ile Pro 
        35                  40                  45              


Asn Thr Asp Phe Thr Phe Lys Ile Glu Pro Asp Thr Thr Val Asn Glu 
    50                  55                  60                  


Asp Gly Asn Lys Phe Lys Gly Val Ala Leu Asn Thr Pro Met Thr Lys 
65                  70                  75                  80  


Val Thr Tyr Thr Asn Ser Asp Lys Gly Gly Ser Asn Thr Lys Thr Ala 
                85                  90                  95      


Glu Phe Asp Phe Ser Glu Val Thr Phe Glu Lys Pro Gly Val Tyr Tyr 
            100                 105                 110         


Tyr Lys Val Thr Glu Glu Lys Ile Asp Lys Val Pro Gly Val Ser Tyr 
        115                 120                 125             


Asp Thr Thr Ser Tyr Thr Val Gln Val His Val Leu Trp Asn Glu Glu 
    130                 135                 140                 


Gln Gln Lys Pro Val Ala Thr Tyr Ile Val Gly Tyr Lys Glu Gly Ser 
145                 150                 155                 160 


Lys Val Pro Ile Gln Phe Lys Asn Ser Leu Asp Ser Thr Thr Leu Thr 
                165                 170                 175     


Val Lys Lys Lys Val Ser Gly Thr Gly Gly Asp Arg Ser Lys Asp Phe 
            180                 185                 190         


Asn Phe Gly Leu Thr Leu Lys Ala Asn Gln Tyr Tyr Lys Ala Ser Glu 
        195                 200                 205             


Lys Val Met Ile Glu Lys Thr Thr Lys Gly Gly Gln Ala Pro Val Gln 
    210                 215                 220                 


Thr Glu Ala Ser Ile Asp Gln Leu Tyr His Phe Thr Leu Lys Asp Gly 
225                 230                 235                 240 


Glu Ser Ile Lys Val Thr Asn Leu Pro Val Gly Val Asp Tyr Val Val 
                245                 250                 255     


Thr Glu Asp Asp Tyr Lys Ser Glu Lys Tyr Thr Thr Asn Val Glu Val 
            260                 265                 270         


Ser Pro Gln Asp Gly Ala Val Lys Asn Ile Ala Gly Asn Ser Thr Glu 
        275                 280                 285             


Gln Glu Thr Ser Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys 
    290                 295                 300                 


Lys Asp Phe Glu Val Pro Thr Gly Val Ala Met Thr Val Ala Pro Tyr 
305                 310                 315                 320 


Ile Ala Leu Gly Ile Val Ala Val Gly Gly Ala Leu Tyr Phe Val Lys 
                325                 330                 335     


Lys Lys Asn Ala 
            340 


<210>  48
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Spy Catcher

<400>  48

Val Asp Thr Leu Ser Gly Leu Ser Ser Glu Gln Gly Gln Ser Gly Asp 
1               5                   10                  15      


Met Thr Ile Glu Glu Asp Ser Ala Thr His Ile Lys Phe Ser Lys Arg 
            20                  25                  30          


Asp Glu Asp Gly Lys Glu Leu Ala Gly Ala Thr Met Glu Leu Arg Asp 
        35                  40                  45              


Ser Ser Gly Lys Thr Ile Ser Thr Trp Ile Ser Asp Gly Gln Val Lys 
    50                  55                  60                  


Asp Phe Tyr Leu Tyr Pro Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala 
65                  70                  75                  80  


Pro Asp Gly Tyr Glu Val Ala Thr Ala Ile Thr Phe Thr Val Asn Glu 
                85                  90                  95      


Gln Gly Gln Val Thr Val Asn Gly Lys Ala Thr Lys Gly Asp Ala His 
            100                 105                 110         


Ile 
    


<210>  49
<211>  139
<212>  PRT
<213>  Artificial

<220>
<223>  Spy Catcher 002

<400>  49

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Val Thr Thr Leu Ser Gly 
            20                  25                  30          


Leu Ser Gly Glu Gln Gly Pro Ser Gly Asp Met Thr Thr Glu Glu Asp 
        35                  40                  45              


Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly Arg Glu 
    50                  55                  60                  


Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile 
65                  70                  75                  80  


Ser Thr Trp Ile Ser Asp Gly His Val Lys Asp Phe Tyr Leu Tyr Pro 
                85                  90                  95      


Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val 
            100                 105                 110         


Ala Thr Ala Ile Thr Phe Thr Val Asn Glu Gln Gly Gln Val Thr Val 
        115                 120                 125             


Asn Gly Glu Ala Thr Lys Gly Asp Ala His Thr 
    130                 135                 


<210>  50
<211>  139
<212>  PRT
<213>  Artificial

<220>
<223>  Spy Catcher 003

<400>  50

Met Ser Tyr Tyr His His His His His His Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ala Met Val Thr Thr Leu Ser Gly 
            20                  25                  30          


Leu Ser Gly Glu Gln Gly Pro Ser Gly Asp Met Thr Thr Glu Glu Asp 
        35                  40                  45              


Ser Ala Thr His Ile Lys Phe Ser Lys Arg Asp Glu Asp Gly Arg Glu 
    50                  55                  60                  


Leu Ala Gly Ala Thr Met Glu Leu Arg Asp Ser Ser Gly Lys Thr Ile 
65                  70                  75                  80  


Ser Thr Trp Ile Ser Asp Gly His Val Lys Asp Phe Tyr Leu Tyr Pro 
                85                  90                  95      


Gly Lys Tyr Thr Phe Val Glu Thr Ala Ala Pro Asp Gly Tyr Glu Val 
            100                 105                 110         


Ala Thr Pro Ile Glu Phe Thr Val Asn Glu Asp Gly Gln Val Thr Val 
        115                 120                 125             


Asp Gly Glu Ala Thr Glu Gly Asp Ala His Thr 
    130                 135                 


<210>  51
<211>  133
<212>  PRT
<213>  Artificial

<220>
<223>  Snoop Catcher

<400>  51

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Lys Pro Leu Arg Gly Ala Val Phe Ser Leu Gln 
            20                  25                  30          


Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn 
        35                  40                  45              


Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe 
    50                  55                  60                  


Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro 
65                  70                  75                  80  


Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val Ala Phe Gln Ile 
                85                  90                  95      


Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val Pro Gln Asp Ile 
            100                 105                 110         


Pro Ala Thr Tyr Glu Phe Thr Asn Gly Lys His Tyr Ile Thr Asn Glu 
        115                 120                 125             


Pro Ile Pro Pro Lys 
    130             


<210>  52
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Sdy Catcher

<400>  52

Leu Ser Gly Glu Thr Gly Gln Ser Gly Asn Thr Thr Ile Glu Glu Asp 
1               5                   10                  15      


Ser Thr Thr His Val Lys Phe Ser Lys Arg Asp Ala Asn Gly Lys Glu 
            20                  25                  30          


Leu Ala Gly Ala Met Ile Glu Leu Arg Asn Leu Ser Gly Gln Thr Ile 
        35                  40                  45              


Gln Ser Trp Ile Ser Asp Gly Thr Val Lys Val Phe Tyr Leu Met Pro 
    50                  55                  60                  


Gly Thr Tyr Gln Phe Val Glu Thr Ala Ala Pro Glu Gly Tyr Glu Leu 
65                  70                  75                  80  


Ala Ala Pro Ile Thr Phe Thr Ile Asp Glu Lys Gly Gln Ile Trp Val 
                85                  90                  95      


Asp Ser 
        


<210>  53
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence of  SpyTag  with linker sequence shown in fig
       1

<400>  53

Gly Ser Gly Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  54
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence of  SpyTag  with linker sequence shown in fig
       1

<400>  54
ggttctggtg ctcacatcgt gatggtcgac gcctacaagc ctaccaaggg ctccggtggc       60


<210>  55
<211>  236
<212>  PRT
<213>  Artificial

<220>
<223>  mCherry

<400>  55

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  56
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  melan A

<400>  56

Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly His 
1               5                   10                  15      


Gly His Ser Tyr Thr Thr Ala Glu Glu Leu Ala Gly Ile Gly Ile Leu 
            20                  25                  30          


Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys Arg 
        35                  40                  45              


Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val Gly 
    50                  55                  60                  


Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp His 
65                  70                  75                  80  


Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val Val 
                85                  90                  95      


Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser Pro 
            100                 105                 110         


Pro Pro Tyr Ser Pro 
        115         


<210>  57
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  A2L

<400>  57

Thr Gly His Ser Tyr Thr Thr Ala Glu Glu Leu Ala Gly Ile Gly Ile 
1               5                   10                  15      


Leu Thr Val 
            


<210>  58
<211>  1273
<212>  PRT
<213>  Coronavirus Cov2


<220>
<221>  MISC_FEATURE
<223>  SARS-CoV2 Spike protein wt

<400>  58

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  59
<211>  223
<212>  PRT
<213>  Coronavirus Cov2


<220>
<221>  MISC_FEATURE
<223>  RBD domain of SARS-CoV2 Spike protein wt

<400>  59

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  60
<211>  223
<212>  PRT
<213>  Coronavirus Cov2


<220>
<221>  MISC_FEATURE
<223>  RBD domain of SARS-CoV2 Spike protein B1.351 variant

<400>  60

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  61
<211>  223
<212>  PRT
<213>  Coronavirus Cov2


<220>
<221>  MISC_FEATURE
<223>  RBD domain of SARS-CoV2 Spike protein P.1 variant

<400>  61

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  62
<211>  805
<212>  PRT
<213>  Artificial

<220>
<223>  ACE2 receptor

<400>  62

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  63
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE3

<400>  63

Thr Glu Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu 
1               5                   10                  


<210>  64
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE7

<400>  64

Thr Glu Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu 
1               5                   10                  


<210>  65
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE11

<400>  65

Ala Lys Ile Glu Ala Ala Thr Ala Ala Ala Glu Ala Lys Ala Asn Ile 
1               5                   10                  15      


Val Ala Ser Asp Ser Thr Arg Val Ala 
            20                  25  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE9

<400>  66

Asp Glu Thr Lys Asn Ala Ala Ala Ala Thr 
1               5                   10  


<210>  67
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE15

<400>  67

Asp Ala Ala Lys Glu Ala Ala Lys Gln Gln Gly 
1               5                   10      


<210>  68
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE4

<400>  68

Ala Ala Ser Thr Ala Ala Val Ala Thr 
1               5                   


<210>  69
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE02

<400>  69

Glu Gln Gly Gly Asp Gly Ala Gly Gly Gly Asn Asn Ser Gly Ser Gly 
1               5                   10                  15      


Ala Glu Glu Asn Ser Asn Ala Ala Ala Ala Ala Met Gln Pro Val Glu 
            20                  25                  30          


Asp Met 
        


<210>  70
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE 14

<400>  70

Ala Lys Ile Glu Ala Ala Ala Glu Ala Lys Ala Asn Ile Val Ala Ser 
1               5                   10                  15      


Asp Ser Thr Arg Val Ala 
            20          


<210>  71
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE10

<400>  71

Asp Glu Thr Lys Asn Ala Ala Ala Ala Thr 
1               5                   10  


<210>  72
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop ADE16

<400>  72

Thr Glu Thr Gly Glu Lys Ala Val Val Lys Thr Thr Thr Val Ala Val 
1               5                   10                  15      


Ala Glu Glu Thr Ser Glu 
            20          


<210>  73
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  First RGD-subloop Addomer Penton base protein of SEQ ID NO :11

<400>  73

Thr Ala Arg Glu Thr Thr Thr Leu Ala Val Ala Glu Glu Thr Ser Glu 
1               5                   10                  15      


Asp Val 
        


<210>  74
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE3

<400>  74

Asp Asp Asp Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Lys 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE7

<400>  75

Asp Asp Asn Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Lys 
1               5                   10                  


<210>  76
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE11

<400>  76

Asn Ala Gly Glu Val Arg Gly Asp Asn Phe Ala Pro Thr Pro 
1               5                   10                  


<210>  77
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE9

<400>  77

Ala Asp Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Pro Ala 
1               5                   10                  


<210>  78
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE15

<400>  78

Asp Gly Ala Val Thr Arg Gly Asp Thr His Leu Thr Val Ala 
1               5                   10                  


<210>  79
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE4

<400>  79

Ala Ser Thr Glu Val Arg Gly Asp Asn Phe Ala Ser Ala Ala 
1               5                   10                  


<210>  80
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE2

<400>  80

Asn Asp His Ala Ile Arg Gly Asp Thr Phe Ala Thr Arg Ala 
1               5                   10                  


<210>  81
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE14

<400>  81

Asn Ala Gly Glu Val Arg Gly Asp Asn Phe Ala Pro Thr Pro 
1               5                   10                  


<210>  82
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE10

<400>  82

Ala Asp Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Pro Ala 
1               5                   10                  


<210>  83
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif ADE16

<400>  83

Asp Asp Asn Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Lys 
1               5                   10                  


<210>  84
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  enlarged RGD-motif Addomer Penton base protein of SEQ ID NO: 11

<400>  84

Asp Asp Asp Ile Thr Arg Gly Asp Thr Tyr Ile Thr Glu Leu 
1               5                   10                  


<210>  85
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE3

<400>  85

Gln Lys Arg Glu Ala Ala Ala Ala Glu Val Lys Lys 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE7

<400>  86

His Lys Arg Glu Ala Ala Ala Ala Glu Val Lys Lys 
1               5                   10          


<210>  87
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE11

<400>  87

Val Pro Thr Ala Glu Ser Leu Leu Ala Asp Val Ser Glu Gly Thr Asp 
1               5                   10                  15      


Val 
    


<210>  88
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE9

<400>  88

Gln Glu Thr Ala Ala Asp Lys 
1               5           


<210>  89
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE15

<400>  89

Gln Glu Lys Ala Ala Gln Lys 
1               5           


<210>  90
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE4

<400>  90

Ala Val Ala Ala Ala Lys Ala Asp Glu Thr Glu Ser 
1               5                   10          


<210>  91
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE2

<400>  91

Glu Glu Lys Arg Ala Glu Ala Glu Ala Ala Ala Glu Ala Ala Ala Pro 
1               5                   10                  15      


Ala Ala Gln Pro Glu Val Glu Lys Pro Gln Lys 
            20                  25          


<210>  92
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE14

<400>  92

Val Pro Thr Ala Glu Ser Leu Leu Ala Asp Val Thr Gly Gly Thr Asn 
1               5                   10                  15      


Val 
    


<210>  93
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE10

<400>  93

Gln Glu Thr Ala Ala Asp Lys 
1               5           


<210>  94
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop ADE16

<400>  94

Gln Lys Arg Glu Ala Ala Ala Ala Glu Leu Leu Leu Met Ser Glu Val 
1               5                   10                  15      


Lys Lys 
        


<210>  95
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Second RGD subloop Addomer Penton base protein of SEQ ID NO :11

<400>  95

Glu Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Val Ser Arg Lys Lys 
1               5                   10                  15      


<210>  96
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Addomer penton base protein with SnoopTag  in Variable loop 
       (ADD-SnoopTag V loop)

<400>  96

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Glu Phe Gly Ser 
145                 150                 155                 160 


Gly Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys Gly Ser Gly 
                165                 170                 175     


Gly Gly Pro Val Asn Asp Thr Tyr Asp His Lys Glu Asp Ile Leu Lys 
            180                 185                 190         


Tyr Glu Trp Phe Glu Phe Ile Leu Pro Glu Gly Asn Phe Ser Ala Thr 
        195                 200                 205             


Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Glu 
    210                 215                 220                 


Ile Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe 
225                 230                 235                 240 


Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Glu Thr Lys Leu Ile 
                245                 250                 255     


Met Pro Gly Val Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile Val Leu 
            260                 265                 270         


Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu 
        275                 280                 285             


Leu Gly Ile Arg Lys Arg His Pro Phe Gln Glu Gly Phe Lys Ile Met 
    290                 295                 300                 


Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Thr 
305                 310                 315                 320 


Ala Tyr Glu Glu Ser Lys Lys Asp Thr Thr Thr Ala Arg Glu Thr Thr 
                325                 330                 335     


Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Val Asp Asp Asp Ile 
            340                 345                 350         


Thr Arg Gly Asp Thr Tyr Ile Thr Glu Leu Glu Lys Gln Lys Arg Glu 
        355                 360                 365             


Ala Ala Ala Ala Glu Val Ser Arg Lys Lys Glu Leu Lys Ile Gln Pro 
    370                 375                 380                 


Leu Glu Lys Asp Ser Lys Ser Arg Ser Tyr Asn Val Leu Glu Asp Lys 
385                 390                 395                 400 


Ile Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ser Tyr Asn Tyr Gly Asn 
                405                 410                 415     


Pro Glu Lys Gly Ile Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val 
            420                 425                 430         


Thr Cys Gly Ala Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln 
        435                 440                 445             


Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Asn Asn Tyr Pro Val 
    450                 455                 460                 


Val Gly Ala Glu Leu Met Pro Val Phe Ser Lys Ser Phe Tyr Asn Glu 
465                 470                 475                 480 


Gln Ala Val Tyr Ser Gln Gln Leu Arg Gln Ala Thr Ser Leu Thr His 
                485                 490                 495     


Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Ile Arg Pro Pro Ala 
            500                 505                 510         


Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His 
        515                 520                 525             


Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr 
    530                 535                 540                 


Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu 
545                 550                 555                 560 


Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 
                565                 570             


<210>  97
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Addomer penton base protein with SnoopTag  in Variable loop 
       (ADD-SnoopTag V loop)

<400>  97
atgaggagac gagccgtgct aggcggagcg gtggtgtatc cggagggtcc tcctccttct       60

tacgagagcg tgatgcagca acaggcggcg atgatacagc ccccactgga ggctcccttc      120

gtacccccac ggtacctggc gcctacggaa gggagaaaca gcattcgtta ctcggagctg      180

tcgcccctgt acgataccac caagttgtat ctggtggaca acaagtcggc ggacatcgcc      240

tccctgaact atcagaacga ccacagcaac ttcctgacca cggtggtgca gaacaatgac      300

tttaccccca cggaggctag cacccagacc atcaactttg acgagcggtc gcgatggggc      360

ggtcagctga agaccatcat gcacaccaac atgcccaacg tgaacgagta catgttcagc      420

aacaagttca aggcgagggt gatggtgtcc agaaaagctc ctgaaggtga attcggttcc      480

ggcaagctgg gtgacatcga gttcatcaag gtgaacaagg gaagcggtgg cggtccggtc      540

aatgacacct atgatcataa agaggatatc ttgaagtatg agtggtttga gttcatttta      600

ccagaaggca acttttcagc caccatgacg atcgacctga tgaacaatgc catcattgac      660

aactacctgg aaattggcag acagaatgga gtgctggaaa gtgacattgg tgttaagttt      720

gacactagaa atttcaggct cgggtgggac cccgaaacta agttgattat gccaggtgtc      780

tacacttatg aggcattcca tcctgacatt gtattgctgc ctggttgcgg ggtagacttt      840

actgaaagcc gacttagcaa cttgcttggc atcaggaaga gacatccatt ccaggagggt      900

ttcaaaatca tgtatgaaga tcttgaaggg ggtaatattc ctgccctttt ggatgtcact      960

gcctatgagg aaagcaaaaa ggataccact actgcgcgcg aaacaaccac actggctgtt     1020

gcagaggaaa ctagtgaaga tgtcgacgat gatataacta gaggagatac ctatataact     1080

gagctcgaaa aacaaaaacg tgaagctgct gctgctgaag tttctagaaa aaaagagtta     1140

aagatccaac ctctggaaaa agacagcaag agtagaagct acaatgtctt ggaagacaaa     1200

atcaacacag cctaccgcag ttggtatctg tcctacaatt acggtaaccc tgagaaagga     1260

ataaggtctt ggacactgct caccacttca gatgtcacct gtggggcaga gcaggtctac     1320

tggtcgctcc ctgacatgat gcaagaccca gtcaccttcc gctccacaag acaagtcaac     1380

aactacccag tggtgggtgc agagcttatg cccgtcttct caaagagttt ctacaatgag     1440

caagccgtgt actctcagca gctccgacag gccacttcgc tcacgcacgt cttcaaccgc     1500

ttccctgaga accagatcct catccgcccg ccggcaccca caattaccac cgtcagtgaa     1560

aacgttcctg ctctcacaga tcacgggacc ctgccgttac gcagcagtat ccggggagtc     1620

cagcgcgtga ccgttactga cgccagacgc cgcacctgtc cctacgttta caaggccctg     1680

ggcatagtcg cgccgcgcgt tctttcaagc cgcactttc                            1719


<210>  98
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Addomer penton base protein with SnoopTag  in Variable loop and 
       SpyTag in RGD loop (ADD-ortho)

<400>  98

Met Arg Arg Arg Ala Val Leu Gly Gly Ala Val Val Tyr Pro Glu Gly 
1               5                   10                  15      


Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Gln Ala Ala Met Ile 
            20                  25                  30          


Gln Pro Pro Leu Glu Ala Pro Phe Val Pro Pro Arg Tyr Leu Ala Pro 
        35                  40                  45              


Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ser Pro Leu Tyr 
    50                  55                  60                  


Asp Thr Thr Lys Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 
65                  70                  75                  80  


Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 
                85                  90                  95      


Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 
            100                 105                 110         


Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His 
        115                 120                 125             


Thr Asn Met Pro Asn Val Asn Glu Tyr Met Phe Ser Asn Lys Phe Lys 
    130                 135                 140                 


Ala Arg Val Met Val Ser Arg Lys Ala Pro Glu Gly Glu Phe Gly Ser 
145                 150                 155                 160 


Gly Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys Gly Ser Gly 
                165                 170                 175     


Gly Gly Pro Val Asn Asp Thr Tyr Asp His Lys Glu Asp Ile Leu Lys 
            180                 185                 190         


Tyr Glu Trp Phe Glu Phe Ile Leu Pro Glu Gly Asn Phe Ser Ala Thr 
        195                 200                 205             


Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Glu 
    210                 215                 220                 


Ile Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe 
225                 230                 235                 240 


Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Glu Thr Lys Leu Ile 
                245                 250                 255     


Met Pro Gly Val Tyr Thr Tyr Glu Ala Phe His Pro Asp Ile Val Leu 
            260                 265                 270         


Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu 
        275                 280                 285             


Leu Gly Ile Arg Lys Arg His Pro Phe Gln Glu Gly Phe Lys Ile Met 
    290                 295                 300                 


Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Thr 
305                 310                 315                 320 


Ala Tyr Glu Glu Ser Lys Lys Asp Thr Thr Thr Ala Arg Glu Thr Thr 
                325                 330                 335     


Thr Leu Ala Val Ala Glu Glu Thr Ser Glu Asp Val Asp Gly Ser Gly 
            340                 345                 350         


Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys Gly Ser Gly 
        355                 360                 365             


Glu Leu Glu Lys Gln Lys Arg Glu Ala Ala Ala Ala Glu Val Ser Arg 
    370                 375                 380                 


Lys Lys Glu Leu Lys Ile Gln Pro Leu Glu Lys Asp Ser Lys Ser Arg 
385                 390                 395                 400 


Ser Tyr Asn Val Leu Glu Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp 
                405                 410                 415     


Tyr Leu Ser Tyr Asn Tyr Gly Asn Pro Glu Lys Gly Ile Arg Ser Trp 
            420                 425                 430         


Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Ala Glu Gln Val Tyr 
        435                 440                 445             


Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr 
    450                 455                 460                 


Arg Gln Val Asn Asn Tyr Pro Val Val Gly Ala Glu Leu Met Pro Val 
465                 470                 475                 480 


Phe Ser Lys Ser Phe Tyr Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu 
                485                 490                 495     


Arg Gln Ala Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn 
            500                 505                 510         


Gln Ile Leu Ile Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu 
        515                 520                 525             


Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser 
    530                 535                 540                 


Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr 
545                 550                 555                 560 


Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu 
                565                 570                 575     


Ser Ser Arg Thr Phe 
            580     


<210>  99
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Addomer penton base protein with SnoopTag  in Variable loop and 
       SpyTag in RGD loop (ADD-ortho)

<400>  99
atgaggagac gagccgtgct aggcggagcg gtggtgtatc cggagggtcc tcctccttct       60

tacgagagcg tgatgcagca acaggcggcg atgatacagc ccccactgga ggctcccttc      120

gtacccccac ggtacctggc gcctacggaa gggagaaaca gcattcgtta ctcggagctg      180

tcgcccctgt acgataccac caagttgtat ctggtggaca acaagtcggc ggacatcgcc      240

tccctgaact atcagaacga ccacagcaac ttcctgacca cggtggtgca gaacaatgac      300

tttaccccca cggaggctag cacccagacc atcaactttg acgagcggtc gcgatggggc      360

ggtcagctga agaccatcat gcacaccaac atgcccaacg tgaacgagta catgttcagc      420

aacaagttca aggcgagggt gatggtgtcc agaaaagctc ctgaaggtga attcggttcc      480

ggcaagctgg gtgacatcga gttcatcaag gtgaacaagg gaagcggtgg cggtccggtc      540

aatgacacct atgatcataa agaggatatc ttgaagtatg agtggtttga gttcatttta      600

ccagaaggca acttttcagc caccatgacg atcgacctga tgaacaatgc catcattgac      660

aactacctgg aaattggcag acagaatgga gtgctggaaa gtgacattgg tgttaagttt      720

gacactagaa atttcaggct cgggtgggac cccgaaacta agttgattat gccaggtgtc      780

tacacttatg aggcattcca tcctgacatt gtattgctgc ctggttgcgg ggtagacttt      840

actgaaagcc gacttagcaa cttgcttggc atcaggaaga gacatccatt ccaggagggt      900

ttcaaaatca tgtatgaaga tcttgaaggg ggtaatattc ctgccctttt ggatgtcact      960

gcctatgagg aaagcaaaaa ggataccact actgcgcgcg aaacaaccac actggctgtt     1020

gcagaggaaa ctagtgaaga tgtcgacggt tccggcgctc acatcgtgat ggtggacgcc     1080

tacaagccta ccaagggaag cggtgagctc gaaaaacaaa aacgtgaagc tgctgctgct     1140

gaagtttcta gaaaaaaaga gttaaagatc caacctctgg aaaaagacag caagagtaga     1200

agctacaatg tcttggaaga caaaatcaac acagcctacc gcagttggta tctgtcctac     1260

aattacggta accctgagaa aggaataagg tcttggacac tgctcaccac ttcagatgtc     1320

acctgtgggg cagagcaggt ctactggtcg ctccctgaca tgatgcaaga cccagtcacc     1380

ttccgctcca caagacaagt caacaactac ccagtggtgg gtgcagagct tatgcccgtc     1440

ttctcaaaga gtttctacaa tgagcaagcc gtgtactctc agcagctccg acaggccact     1500

tcgctcacgc acgtcttcaa ccgcttccct gagaaccaga tcctcatccg cccgccggca     1560

cccacaatta ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gaccctgccg     1620

ttacgcagca gtatccgggg agtccagcgc gtgaccgtta ctgacgccag acgccgcacc     1680

tgtccctacg tttacaaggc cctgggcata gtcgcgccgc gcgttctttc aagccgcact     1740

ttc                                                                   1743


