﻿                         序列表

<110>  正大天晴药业集团股份有限公司

<120>  靶向BCMA的多特异性抗体

<150>  202110405638.3
<151>  2021-04-15

<160>  84

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  肽接头


<400>  1
Gly Gly Gly Gly Ser 
1               5   

<210>  2
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  肽接头


<400>  2
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  

<210>  3
<211>  16
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  铰链区


<400>  3
Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      

<210>  4
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  铰链区


<400>  4
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210>  5
<211>  232
<212>  PRT
<213>  Homo sapiens

<220>
<223>  人IgG1恒定区


<400>  5
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         

<210>  6
<211>  183
<212>  PRT
<213>  食蟹猕猴(Macaca fascicularis)

<220>
<223>  食蟹猴BCMA全长


<400>  6
Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
            20                  25                  30          
Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
        35                  40                  45              
Lys Gly Met Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile 
    50                  55                  60                  
Ile Ser Leu Ala Val Phe Val Leu Thr Phe Leu Leu Arg Lys Met Ser 
65                  70                  75                  80  
Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu 
                85                  90                  95      
Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr Gly Asp Glu Ile 
            100                 105                 110         
Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
        115                 120                 125             
Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 
    130                 135                 140                 
Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
145                 150                 155                 160 
Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser Val Thr Glu Ile 
                165                 170                 175     
Glu Lys Ser Ile Ser Ala Arg 
            180             

<210>  7
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A1单可变结构域CDR1


<400>  7
Gly Trp Asn Lys His 
1               5   

<210>  8
<211>  16
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A1单可变结构域CDR2


<400>  8
Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  9
<211>  10
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A1单可变结构域CDR3


<400>  9
Asp Leu Pro Gly Ser Gly Leu Pro Ala Phe 
1               5                   10  

<210>  10
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A10单可变结构域CDR1


<400>  10
Val Ala Cys Met Ala 
1               5   

<210>  11
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A10单可变结构域CDR2


<400>  11
Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  12
<211>  14
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A10单可变结构域CDR3


<400>  12
Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
1               5                   10                  

<210>  13
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A11单可变结构域CDR1


<400>  13
Ser Ala Cys Met Gly 
1               5   

<210>  14
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A11单可变结构域CDR2


<400>  14
Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  15
<211>  17
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A11单可变结构域CDR3


<400>  15
Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp Tyr Asn 
1               5                   10                  15      
Tyr 
    

<210>  16
<211>  5
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1B10单可变结构域CDR1


<400>  16
Gly Trp Asn Lys His 
1               5   

<210>  17
<211>  16
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1B10单可变结构域CDR2


<400>  17
Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  18
<211>  10
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1B10单可变结构域CDR3


<400>  18
Asp Leu Pro Gly Ser Gly Leu Pro Glu Phe 
1               5                   10  

<210>  19
<211>  118
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A1单可变结构域


<400>  19
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Ala Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  20
<211>  354
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A1单可变结构域


<400>  20
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ccggagggtc tctgagactc        60
tcctgtacag cctctggata caccttcagg ggctggaaca agcactggta ccgccaggct       120
ccagggaagg agcgcgagtt ggtctcgagc atctttcgtg atgggaagac agcctataca       180
gactccgtga agggccgatt caccatctct caagacaacg ccgacgcaac ggtgtatctg       240
caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaaata cgatctgcct       300
ggatctggtc ttcctgcatt ctggggccag gggaccctgg tcactgtctc atca             354

<210>  21
<211>  123
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A10单可变结构域


<400>  21
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  22
<211>  369
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A10单可变结构域


<400>  22
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc gctgagactc        60
tcctgtgccg cctccggata cagcagtaat gtggcatgca tggcctggta ccgccaggct       120
ccagggaagg agcgcgagtg ggtcgcaact attgttgctg atttcggtac cacaaactat       180
gccgcctccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat       240
ctgcaaatga acagcctgaa acctgaggac tctgccatgt actactgtgc ggcaacccag       300
agggggggta ttgactggtg tgatgaaatt aattactggg gccaggggac cctggtcact       360
gtctcatca                                                               369

<210>  23
<211>  126
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A11单可变结构域


<400>  23
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  24
<211>  378
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1A11单可变结构域


<400>  24
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc        60
tcctgtgcag cctctggagt cacttttaat agcgcatgta tgggttggtt ccgccaggct       120
ccagggaagg agcgcgaggg ggtcgcacgt attgaaactg gttatggtgg cactgtctat       180
gccgactccg tgaagggacg attcaccatc tcccgagaca acgccaagaa cacggtgtat       240
ctgcaaatga acagcctaaa acctgaggac actgccatgt actactgtgc ggctaagaga       300
tcctggtgta ctcctacgtg gtggcacgaa cttgactata actactgggg acaggggacc       360
caggtcactg tctcatca                                                     378

<210>  25
<211>  118
<212>  PRT
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1B10单可变结构域


<400>  25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Glu Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  26
<211>  354
<212>  DNA
<213>  双峰驼(Camelus bactrianus)

<220>
<223>  1B10单可变结构域


<400>  26
gaggtgcagc tggtggagtc tgggggaggc tcggtgcagg ccggagggtc tctgagactc        60
tcctgtacag cctctggata caccttcagg ggctggaaca agcactggta ccgccaggct       120
ccagggaagg agcgcgagtt ggtctcgagt atctttcgtg atgggaagac agcctataca       180
gactccgtga agggccgatt caccatctct caagacagcg ccgacgcaac ggtgtatctg       240
caaatgaaca gcctgaaacc tgaggacacg gccatgtatt actgtaaata cgatctgcct       300
ggatctggtc ttcctgagtt ctggggccag gggaccctgg tcactgtctc atca             354

<210>  27
<211>  350
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A1-Fc


<400>  27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Ala Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 

<210>  28
<211>  1050
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A1-Fc


<400>  28
caagtgcaac tggtggagtc tggaggcggt tccgtgcagg ccggcggctc cctgagactg        60
tcctgcaccg cttccggcta caccttcaga ggctggaaca agcactggta tcggcaggct       120
cctggcaaag aaagagagct ggtgtcctcc atcttccggg acggcaagac cgcctacacc       180
gactccgtga agggcagatt caccatctct caggacaacg ccgacgccac agtgtacctg       240
cagatgaact ctctgaagcc cgaggacacc gccatgtact actgcaagta cgacctgcct       300
ggatctggcc tgcccgcctt ctggggccaa ggcaccctgg taaccgtgtc gtccgagccc       360
aagtcttgcg acaagaccca cacctgtcct ccttgtcctg ctccggaact gctgggcggc       420
ccttccgtgt ttctgtttcc tccaaagcct aaggacacac tgatgatcag ccggacccct       480
gaggtgacct gcgtggtcgt ggatgtctct cacgaggatc ctgaggtgaa gttcaactgg       540
tacgtggatg gagtggaagt gcataacgct aaaaccaagc ctagagaaga gcagtacaac       600
tccacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa       660
gagtacaagt gcaaggtgtc caacaaggct ctgcctgccc ctatcgagaa gaccatctcc       720
aaggccaagg gccagcctcg ggagcctcaa gtgtacaccc tgcctccttc tcgcgacgag       780
ctgaccaaga accaggtgtc tctgacctgc ctggtgaaag gcttctaccc ctccgacatc       840
gccgtggaat gggagtccaa tggccagccc gagaacaact acaagaccac cccacctgtg       900
ctggactctg atggctcctt cttcctgtac tccaagctga ccgtggacaa gtccagatgg       960
cagcagggca acgtgttctc ctgttctgtg atgcacgagg ccctgcacaa ccactacaca      1020
cagaagtccc tgagcctgtc tcctggcaag                                       1050

<210>  29
<211>  355
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-Fc


<400>  29
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
        115                 120                 125             
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         
Pro Gly Lys 
        355 

<210>  30
<211>  1065
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-Fc


<400>  30
caggtgcaac tggtggagtc tggcggcgga tctgtgcaag ctggcggatc cctgagactg        60
tcttgtgccg cttccggcta ctcctctaac gtggcctgta tggcctggta cagacaggcc       120
cctggcaaag aaagagagtg ggtcgccacc atcgtggccg atttcggcac caccaattac       180
gccgcttccg tgaagggcag attcaccatc tctcaggaca acgccaagaa caccgtgtac       240
ctgcagatga actccctgaa gcctgaggac tccgccatgt actactgcgc cgctacacag       300
cgcggaggca ttgattggtg cgacgagatt aactactggg gccaaggcac cctggttacc       360
gtgtcctctg agcccaagtc ctgcgacaag acccacacct gtccaccttg tcctgcccca       420
gaactgctgg gcggtcccag cgtgttcctg ttccccccca agcctaagga cacactgatg       480
atctctagaa cccctgaagt gacctgcgtg gtggtcgatg tatctcacga ggatcctgag       540
gtcaagttca actggtacgt ggacggagtg gaagtgcata atgctaagac caagcctaga       600
gaggaacagt acaactccac ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat       660
tggctgaacg gcaaggagta caagtgcaag gtgtccaaca aggctctgcc tgctcctatc       720
gagaagacca tcagcaaggc caagggccag cctcgggagc ctcaagtgta caccctgcct       780
ccttctcggg acgagctgac caagaaccag gtgtctctta catgcctggt gaaaggcttc       840
tacccttccg acatcgccgt ggaatgggag tccaatggcc agcccgagaa caactacaag       900
accacacctc ctgtgctgga ctctgacggc tccttcttcc tgtactccaa gctgacagtg       960
gataagtcca gatggcagca gggcaacgtg ttctcctgct ccgtgatgca cgaggccctg      1020
cacaaccact acacccagaa gtctctgagc ctgtcccctg gaaaa                      1065

<210>  31
<211>  358
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-Fc


<400>  31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
        115                 120                 125             
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    130                 135                 140                 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
145                 150                 155                 160 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                165                 170                 175     
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            180                 185                 190         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        195                 200                 205             
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    210                 215                 220                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
225                 230                 235                 240 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                245                 250                 255     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            260                 265                 270         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        275                 280                 285             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    290                 295                 300                 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
305                 310                 315                 320 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                325                 330                 335     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            340                 345                 350         
Ser Leu Ser Pro Gly Lys 
        355             

<210>  32
<211>  1074
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-Fc


<400>  32
caggtgcagt tggttgaatc tggcggcgga tctgtgcagg ctggcggatc tctgagactg        60
tcctgtgccg cttccggcgt caccttcaac tccgcttgca tgggatggtt cagacaggcc       120
cctggcaaag agagagaggg cgtcgctagg atcgagaccg gctatggcgg aaccgtctac       180
gccgactccg tcaagggcag gttcaccatc agcagagaca acgccaagaa caccgtgtac       240
ctgcagatga actccctgaa gcccgaggac accgccatgt actactgtgc tgccaagaga       300
agctggtgca cccctacctg gtggcacgag ctggactaca actactgggg ccagggcaca       360
caggtcaccg tgtcctctga gcctaagtcc tgcgacaaga cccacacctg tcctccatgt       420
cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggat       480
accctgatga tctctcggac ccctgaagtg acctgcgtgg tggtggatgt gtctcacgag       540
gatcccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa tgctaagacc       600
aagcctagag aggaacagta caactccacc tatagagtgg tgtccgtgct gaccgtgctg       660
caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct       720
gctcctatcg aaaagaccat ctccaaggcc aagggccagc ctagggaacc ccaggtttac       780
accttgcctc catctcggga cgagctgacc aagaaccagg tgtccctgac ctgtctggtc       840
aagggcttct acccctccga tatcgccgtg gaatgggagt ctaatggcca gccagagaac       900
aactacaaga caacccctcc tgtgctggac tccgacggct cattcttcct gtactccaag       960
ctgacagtgg acaagtccag atggcagcag ggcaacgtgt tctcctgctc cgtgatgcac      1020
gaggccctgc acaatcacta cacccagaag tccctgtctc tgagccccgg caaa            1074

<210>  33
<211>  350
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B10-Fc


<400>  33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Phe Arg Gly Trp 
            20                  25                  30          
Asn Lys His Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              
Ser Ser Ile Phe Arg Asp Gly Lys Thr Ala Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Asp Ala Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Lys 
                85                  90                  95      
Tyr Asp Leu Pro Gly Ser Gly Leu Pro Glu Phe Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 

<210>  34
<211>  1050
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1B10-Fc


<400>  34
gaggtgcaac tggtggagtc tggaggcggt tccgtgcagg ccggcggctc cctgagactg        60
tcctgcaccg cttccggcta caccttcaga ggctggaaca agcactggta tcggcaggct       120
cctggcaaag aaagagagct ggtgtcctcc atcttccggg acggcaagac cgcctacacc       180
gactccgtga agggcagatt caccatctct caggactctg ccgacgccac agtgtacctg       240
cagatgaact ctctgaagcc cgaggacacc gccatgtact actgcaagta cgacctgcct       300
ggatctggcc tgcccgagtt ctggggccaa ggcaccctgg taaccgtgtc gtccgagccc       360
aagtcttgcg acaagaccca cacctgtcct ccttgtcctg ctccggaact gctgggcggc       420
ccttccgtgt ttctgtttcc tccaaagcct aaggacacac tgatgatcag ccggacccct       480
gaggtgacct gcgtggtcgt ggatgtctct cacgaggatc ctgaggtgaa gttcaactgg       540
tacgtggatg gagtggaagt gcataacgct aaaaccaagc ctagagaaga gcagtacaac       600
tccacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa       660
gagtacaagt gcaaggtgtc caacaaggct ctgcctgccc ctatcgagaa gaccatctcc       720
aaggccaagg gccagcctcg ggagcctcaa gtgtacaccc tgcctccttc tcgcgacgag       780
ctgaccaaga accaggtgtc tctgacctgc ctggtgaaag gcttctaccc ctccgacatc       840
gccgtggaat gggagtccaa tggccagccc gagaacaact acaagaccac cccacctgtg       900
ctggactctg atggctcctt cttcctgtac tccaagctga ccgtggacaa gtccagatgg       960
cagcagggca acgtgttctc ctgttctgtg atgcacgagg ccctgcacaa ccactacaca      1020
cagaagtccc tgagcctgtc tcctggcaag                                       1050

<210>  35
<211>  54
<212>  PRT
<213>  智人(Homo sapiens)

<220>
<223>  人BCMA胞外区


<400>  35
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          
Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              
Val Lys Gly Thr Asn Ala 
    50                  

<210>  36
<211>  53
<212>  PRT
<213>  食蟹猕猴(Macaca fascicularis)

<220>
<223>  食蟹猴BCMA胞外区


<400>  36
Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      
Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
            20                  25                  30          
Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
        35                  40                  45              
Lys Gly Met Asn Ala 
    50              

<210>  37
<211>  123
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-V1单可变结构域


<400>  37
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  38
<211>  123
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-V2单可变结构域


<400>  38
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  39
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-V1单可变结构域


<400>  39
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              
Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  40
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-V2单可变结构域


<400>  40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  41
<211>  123
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (11)
<223>  Xaa is S or L


<220>
<221>  UNSURE
<222>  (14)
<223>  Xaa is P or A


<220>
<221>  UNSURE
<222>  (44)
<223>  Xaa is G or E


<220>
<221>  UNSURE
<222>  (45)
<223>  Xaa is R or L


<220>
<221>  UNSURE
<222>  (49)
<223>  Xaa is A or S


<220>
<221>  UNSURE
<222>  (75)
<223>  Xaa is A or S


<220>
<221>  UNSURE
<222>  (87)
<223>  Xaa is R or K


<220>
<221>  UNSURE
<222>  (88)
<223>  Xaa is A or P


<220>
<221>  UNSURE
<222>  (91)
<223>  Xaa is T or S


<220>
<221>  UNSURE
<222>  (93)
<223>  Xaa is V or M


<220>
<223>  结合BCMA的单可变结构域


<400>  41
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Xaa Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Trp Val 
        35                  40                  45              
Xaa Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Xaa Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Xaa Ala Xaa Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210>  42
<211>  126
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (11)
<223>  Xaa is S or L


<220>
<221>  UNSURE
<222>  (14)
<223>  Xaa is P or A


<220>
<221>  UNSURE
<222>  (27)
<223>  Xaa is F or V


<220>
<221>  UNSURE
<222>  (44)
<223>  Xaa is E or G


<220>
<221>  UNSURE
<222>  (49)
<223>  Xaa is A or S


<220>
<221>  UNSURE
<222>  (75)
<223>  Xaa is A or S


<220>
<221>  UNSURE
<222>  (87)
<223>  Xaa is R or K


<220>
<221>  UNSURE
<222>  (88)
<223>  Xaa is A or P


<220>
<221>  UNSURE
<222>  (93)
<223>  Xaa is V or M


<220>
<223>  结合BCMA的单可变结构域


<400>  42
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Xaa Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Xaa Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Xaa Arg Glu Gly Val 
        35                  40                  45              
Xaa Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  43
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-HCDR1


<400>  43
Thr Tyr Ala Met Asn 
1               5   

<210>  44
<211>  19
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-HCDR2


<400>  44
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210>  45
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-HCDR3


<400>  45
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210>  46
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-LCDR1


<400>  46
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210>  47
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-LCDR2


<400>  47
Gly Thr Asn Lys Arg Ala Pro 
1               5           

<210>  48
<211>  9
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-LCDR3


<400>  48
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   

<210>  49
<211>  125
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-VH


<400>  49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210>  50
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  CD3-VL


<400>  50
Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210>  51
<211>  356
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-V1


<400>  51
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Glu Pro Lys Ser 
        115                 120                 125             
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         
Ser Pro Gly Lys 
        355     

<210>  52
<211>  1068
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-V1


<400>  52
caggtgcagc tggtggagtc cggcggcgga ctggtgcagc ctggaggatc tctgcggctg        60
tcctgcgccg ccagcggata ctccagcaac gtggcttgca tggcctggta tcggcaggcc       120
cctggcaagg gcctggagtg ggtggctacc atcgtggctg acttcggcac caccaattat       180
gccgctagcg tgaagggccg gttcaccatc agccaggata actccaagaa taccgtgtat       240
ctgcagatga atagcctgcg ggccgaggat accgccgtgt attattgtgc cgctacccag       300
cggggcggca tcgactggtg tgatgagatc aactattggg gccagggcac cctggtgacc       360
gtgtcctccg gcgagcctaa gtcctccgac aagacccaca cctgccctcc ttgtcccgcc       420
cctgagctgc tgggcggacc atctgtgttc ctgttccctc ccaagcccaa ggacaccctg       480
atgatctcca ggacccctga ggtgacctgc gtggtggtgg atgtgtccca cgaggaccct       540
gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaatgctaa gaccaagccc       600
cgggaggagc agtataacag cacctaccgg gtggtgagcg tgctgaccgt gctgcaccag       660
gattggctga atggcaagga gtacaagtgt aaggtgtcca acaaggctct gcctgccccc       720
atcgagaaga ccatctccaa ggccaagggc cagcctcggg agccccaggt gtataccctg       780
cccccctcca gggacgagct gaccaagaac caggtgagcc tgacctgtct ggtgaagggc       840
ttctatcctt ccgacatcgc cgtggagtgg gagtccaacg gccagcctga gaataactac       900
aagaccaccc cccctgtgct ggatagcgac ggctccttct tcctgtattc caagctgacc       960
gtggataagt cccggtggca gcagggcaat gtgttcagct gttccgtgat gcacgaggct      1020
ctgcacaacc actataccca gaagtccctg tccctgagcc ccggcaag                   1068

<210>  53
<211>  356
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-V2


<400>  53
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ser Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Glu Pro Lys Ser 
        115                 120                 125             
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            260                 265                 270         
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         
Ser Pro Gly Lys 
        355     

<210>  54
<211>  1068
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A10-V2


<400>  54
caggtgcagc tggtggagtc cggcggcgga ctggtgcagc ctggaggatc tctgcggctg        60
tcctgcgccg ccagcggata ctccagcaac gtggcttgca tggcctggta tcggcaggcc       120
cctggcaagg agcgggagtg ggtgagcacc atcgtggctg acttcggcac caccaattat       180
gccgctagcg tgaagggccg gttcaccatc agccaggata actccaagaa taccgtgtat       240
ctgcagatga atagcctgcg ggccgaggat accgccgtgt attattgtgc cgctacccag       300
cggggcggca tcgactggtg tgatgagatc aactattggg gccagggcac cctggtgacc       360
gtgtcctccg gcgagcctaa gtcctccgac aagacccaca cctgccctcc ttgtcccgcc       420
cctgagctgc tgggcggacc atctgtgttc ctgttccctc ccaagcccaa ggacaccctg       480
atgatctcca ggacccctga ggtgacctgc gtggtggtgg atgtgtccca cgaggaccct       540
gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaatgctaa gaccaagccc       600
cgggaggagc agtataacag cacctaccgg gtggtgagcg tgctgaccgt gctgcaccag       660
gattggctga atggcaagga gtacaagtgt aaggtgtcca acaaggctct gcctgccccc       720
atcgagaaga ccatctccaa ggccaagggc cagcctcggg agccccaggt gtataccctg       780
cccccctcca gggacgagct gaccaagaac caggtgagcc tgacctgtct ggtgaagggc       840
ttctatcctt ccgacatcgc cgtggagtgg gagtccaacg gccagcctga gaataactac       900
aagaccaccc cccctgtgct ggatagcgac ggctccttct tcctgtattc caagctgacc       960
gtggataagt cccggtggca gcagggcaat gtgttcagct gttccgtgat gcacgaggct      1020
ctgcacaacc actataccca gaagtccctg tccctgagcc ccggcaag                   1068

<210>  55
<211>  359
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-V1


<400>  55
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              
Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Glu 
        115                 120                 125             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         
Leu Ser Leu Ser Pro Gly Lys 
        355                 

<210>  56
<211>  1077
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-V1


<400>  56
caggtgcagc tggtggagtc cggcggcgga ctggtgcagc caggaggatc tctgcggctg        60
tcctgtgccg cttccggctt caccttcaat tccgcttgca tgggctggtt caggcaggcc       120
cctggcaagg gcagggaggg agtgtccagg atcgagaccg gctacggcgg caccgtgtac       180
gctgacagcg tgaagggccg gttcaccatc agccgggata actccaagaa caccgtgtat       240
ctgcagatga atagcctgag ggctgaggat accgccgtgt actattgtgc tgctaagcgg       300
tcctggtgta cccccacctg gtggcacgag ctggactaca attactgggg ccagggcacc       360
caggtgaccg tgagctccgg cgagcctaag tcctccgaca agacccacac ctgccctcct       420
tgtcccgccc ctgagctgct gggcggacca tctgtgttcc tgttccctcc caagcccaag       480
gacaccctga tgatctccag gacccctgag gtgacctgcg tggtggtgga tgtgtcccac       540
gaggaccctg aggtgaagtt caactggtac gtggacggcg tggaggtgca caatgctaag       600
accaagcccc gggaggagca gtataacagc acctaccggg tggtgagcgt gctgaccgtg       660
ctgcaccagg attggctgaa tggcaaggag tacaagtgta aggtgtccaa caaggctctg       720
cctgccccca tcgagaagac catctccaag gccaagggcc agcctcggga gccccaggtg       780
tataccctgc ccccctccag ggacgagctg accaagaacc aggtgagcct gacctgtctg       840
gtgaagggct tctatccttc cgacatcgcc gtggagtggg agtccaacgg ccagcctgag       900
aataactaca agaccacccc ccctgtgctg gatagcgacg gctccttctt cctgtattcc       960
aagctgaccg tggataagtc ccggtggcag cagggcaatg tgttcagctg ttccgtgatg      1020
cacgaggctc tgcacaacca ctatacccag aagtccctgt ccctgagccc cggcaag         1077

<210>  57
<211>  359
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-V2


<400>  57
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              
Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Glu 
        115                 120                 125             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         
Leu Ser Leu Ser Pro Gly Lys 
        355                 

<210>  58
<211>  1077
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  1A11-V2


<400>  58
caggtgcagc tggtggagtc cggcggcgga ctggtgcagc caggaggatc tctgcggctg        60
tcctgtgccg cttccggctt caccttcaat tccgcttgca tgggctggtt caggcaggcc       120
cctggcaagg agagggaggg agtgtccagg atcgagaccg gctacggcgg caccgtgtac       180
gctgacagcg tgaagggccg gttcaccatc agccgggata actccaagaa caccgtgtat       240
ctgcagatga atagcctgaa ggctgaggat accgccgtgt actattgtgc tgctaagcgg       300
tcctggtgta cccccacctg gtggcacgag ctggactaca attactgggg ccagggcacc       360
caggtgaccg tgagctccgg cgagcctaag tcctccgaca agacccacac ctgccctcct       420
tgtcccgccc ctgagctgct gggcggacca tctgtgttcc tgttccctcc caagcccaag       480
gacaccctga tgatctccag gacccctgag gtgacctgcg tggtggtgga tgtgtcccac       540
gaggaccctg aggtgaagtt caactggtac gtggacggcg tggaggtgca caatgctaag       600
accaagcccc gggaggagca gtataacagc acctaccggg tggtgagcgt gctgaccgtg       660
ctgcaccagg attggctgaa tggcaaggag tacaagtgta aggtgtccaa caaggctctg       720
cctgccccca tcgagaagac catctccaag gccaagggcc agcctcggga gccccaggtg       780
tataccctgc ccccctccag ggacgagctg accaagaacc aggtgagcct gacctgtctg       840
gtgaagggct tctatccttc cgacatcgcc gtggagtggg agtccaacgg ccagcctgag       900
aataactaca agaccacccc ccctgtgctg gatagcgacg gctccttctt cctgtattcc       960
aagctgaccg tggataagtc ccggtggcag cagggcaatg tgttcagctg ttccgtgatg      1020
cacgaggctc tgcacaacca ctatacccag aagtccctgt ccctgagccc cggcaag         1077

<210>  59
<211>  492
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  A10-linker-A11-Fc


<400>  59
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
    130                 135                 140                 
Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val 
145                 150                 155                 160 
Thr Phe Asn Ser Ala Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     
Glu Arg Glu Gly Val Ala Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val 
            180                 185                 190         
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
    210                 215                 220                 
Ala Met Tyr Tyr Cys Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp 
225                 230                 235                 240 
Trp His Glu Leu Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     
Val Ser Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         
Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             
Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 
Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
                405                 410                 415     
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             
Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         

<210>  60
<211>  1476
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  A10-linker-A11-Fc


<400>  60
caggtgcagc tggtggagag cggcggcgga tccgtgcagg ctggaggaag cctgcggctg        60
tcctgtgccg cctccggata ctcctccaac gtggcctgta tggcttggta caggcaggct       120
cctggcaagg agcgggagtg ggtggctacc atcgtggccg acttcggcac caccaattac       180
gctgctagcg tgaagggcag gttcaccatc agccaggata acgctaagaa taccgtgtac       240
ctgcagatga atagcctgaa gcccgaggac tccgctatgt actattgtgc cgctacccag       300
aggggcggca tcgattggtg cgacgagatc aattattggg gccagggcac cctggtgacc       360
gtgagcagcg gcggaggcgg aagcggagga ggaggaagcc aggtgcagct cgtggagtcc       420
ggcggcggaa gcgtgcaggc tggtggaagc ctgaggctgt cctgtgctgc tagcggcgtg       480
accttcaact ccgcttgtat gggctggttc cggcaggctc ccggcaagga gagagagggc       540
gtggccagga tcgagaccgg ctatggcggc accgtgtacg ccgacagcgt gaagggacgg       600
ttcaccatct ccagggataa cgctaaaaac accgtgtatc tgcagatgaa cagcctgaag       660
ccagaggata ccgctatgta ttactgtgct gccaagcgga gctggtgtac ccctacctgg       720
tggcacgagc tggactacaa ctattggggc cagggaaccc aggtgaccgt gtccagcggc       780
gagcccaagt ccagcgacaa gacccacacc tgtcctcctt gccctgctcc agaggccgct       840
ggcggaccta gcgtgttcct gttccctcct aagcctaagg acaccctgat gatctccaga       900
acacctgaag tgacctgcgt ggtcgtggat gtttctcacg aggaccctga ggtgaagttc       960
aactggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctcg ggaggaacag      1020
tacaactcca cctacagagt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      1080
ggaaaagagt acaagtgcaa ggtgtccaac aaggccctgg ccgctcctat cgagaagact      1140
atctccaagg ctaagggcca gcctagagag cctcaagtgt gcaccctgcc tccatctcgg      1200
gaagagatga ccaagaacca ggtgtctctg tcttgcgccg tcaagggctt ctacccttcc      1260
gacatcgccg tggaatggga gtctaacggc cagcctgaga acaactacaa gaccacccct      1320
cctgtgctgg actctgacgg ctccttcttc ctcgtgtcca agctgaccgt ggacaagtct      1380
cggtggcagc agggcaacgt gttctcctgc tctgtgatgc acgaggctct gcacaaccac      1440
tacacccaga agtccctgtc cctgtcccct ggcaag                                1476

<210>  61
<211>  455
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-HC-Fc


<400>  61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     
Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         
Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys 
        355                 360                 365             
Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         
Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
        435                 440                 445             
Leu Ser Leu Ser Pro Gly Lys 
    450                 455 

<210>  62
<211>  1365
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-HC-Fc


<400>  62
gaggtgcagc tggtggaatc tggcggaggc ctcgtgcagc ccggcggctc tctgagactg        60
tcttgcgccg cttctggctt taccttcaat acctatgcca tgaattgggt gcggcaggcc       120
cctggcaagg gcctggaatg ggtcgccaga atcagatcca agtacaacaa ctacgccacc       180
tactacgccg attctgtgaa agacagattc accatctctc gggacgactc taagaacacc       240
gcctacctgc agatgaacaa cctgaagacc gaggacaccg ctatgtacta ctgcgtgaga       300
cacggcaact tcggcaactc ctacgtgtcc tggttcgcct actggggcca gggcaccctg       360
gtcacagttt cttctgcctc taccaagggc ccttccgtgt tccctctggc ccctagcagc       420
aaaagcacct ccggcggaac cgccgccctg ggctgtctgg tgaaggacta cttccccgag       480
cctgtgacgg tgtcttggaa ctccggcgct ctgacctctg gcgtgcatac ctttcctgcc       540
gtgctgcagt ccagcggact gtactccctg tcctccgtcg tgacagttcc ctcctctagc       600
ctgggcacac agacctacat ctgcaacgtg aaccacaagc cttctaacac caaagtggac       660
aagaaggtgg aacccaaatc ctgcgacaag acacacacct gtcctccttg ccctgctcct       720
gaggccgctg gcggccctag cgtgtttctg tttcctccta agcccaagga cacactgatg       780
atctccagaa ccccagaagt gacctgcgta gtggtggacg tgtcccacga ggatcctgag       840
gtgaagttca actggtacgt ggatggcgtg gaagtgcaca acgccaagac caagcctaga       900
gaagagcagt acaactccac ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggac       960
tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctggc tgctcctatc      1020
gagaagacca tctccaaggc taagggacag cctcgggaac ctcaagtgta caccctgcct      1080
ccttgtagag aggaaatgac caagaaccag gtgtctctgt ggtgcctggt caagggcttc      1140
tacccttctg acatcgccgt ggagtgggag tccaacggcc agcctgagaa caactacaaa      1200
accacccctc cagtgctgga ctccgacggc tccttcttcc tgtactccaa gctgacagtg      1260
gataagtcta gatggcagca gggcaatgtg ttctcctgct ccgtgatgca cgaggctctg      1320
cacaaccggt tcacccagaa gtccctgtcc ctgtcccctg gcaag                      1365

<210>  63
<211>  215
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-LC


<400>  63
Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
145                 150                 155                 160 
Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Thr Glu Cys Ser 
    210                 215 

<210>  64
<211>  645
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-LC


<400>  64
gagctggtgg tgacccagga gccatccctg accacaagcc caggaggaac cgtgacactg        60
acctgtagat ccagcaccgg cgccgtgacc acaagcaact acgctaattg ggtgcagcag       120
aagcctggac aggctccaag gggactgatc ggaggaacca acaagagagc ccccggaaca       180
ccagctcggt tttccggcag cctgctggga ggcaaggccg ctctgacaat caccggcgtg       240
cagccagagg acgaggccga gtactattgc gctctgtggt attctaatct gtgggtgttt       300
ggaggaggaa caaagctgac cgtgctggga cagcccaagg ctaaccctac agtgaccctg       360
ttcccccctt cttccgagga gctgcaggcc aataaggcca ccctggtgtg cctgatctct       420
gacttttacc caggagctgt gacagtggct tggaaggctg atggctcccc tgtgaaggct       480
ggcgtggaga ccacaaagcc aagcaagcag tctaacaata agtacgccgc tagctcttat       540
ctgtctctga cccccgagca gtggaagtcc cacaggtctt attcctgcca ggtgacacat       600
gagggcagca cagtggagaa gaccgtggcc cctacagagt gttct                       645

<210>  65
<211>  492
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A10-v1-linker-A11-v1-Fc


<400>  65
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 
Thr Phe Asn Ser Ala Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     
Gly Arg Glu Gly Val Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val 
            180                 185                 190         
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp 
225                 230                 235                 240 
Trp His Glu Leu Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     
Val Ser Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         
Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             
Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 
Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
                405                 410                 415     
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             
Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490         

<210>  66
<211>  1476
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A10-v1-linker-A11-v1-Fc


<400>  66
caagtgcagc tggtcgagtc cggcggcgga ctggtgcagc caggcggctc cctccggctg        60
tcctgtgccg cctccggcta ctcctctaac gtggcctgca tggcctggta tagacaggct       120
cctggcaagg gcctggaatg ggtggccacc attgtggccg acttcggcac caccaactac       180
gccgcttccg tcaagggcag attcaccatc tcccaggata actccaagaa caccgtgtac       240
ctgcagatga actccctgag ggctgaagat accgctgtgt actactgtgc tgccacacag       300
agaggcggca tcgattggtg cgacgagatc aactattggg gacagggcac tttggtgacc       360
gtgtccagcg gaggcggcgg ctccggcggg ggcggctctc aggttcagct ggtcgagtcc       420
ggcggtggcc tggtgcagcc cggcggaagc ctgagactgt cctgcgccgc ctctggcttt       480
accttcaact ctgcctgtat gggctggttt cggcaagccc ctgggaaagg cagagagggc       540
gtgagccgga tcgagacagg ctacggcggc acagtttacg ctgactctgt gaagggaaga       600
ttcaccatca gccgggacaa ttccaaaaat accgtgtacc tgcagatgaa cagcctgcgg       660
gccgaggaca cagctgtcta ctactgcgcg gccaagcggt cttggtgtac ccctacctgg       720
tggcacgagc tggactacaa ctactggggc cagggaactc aggtgaccgt gtcctccggc       780
gagcccaagt cctctgacaa gacacacacc tgtcctccat gccctgctcc tgaggccgct       840
ggcggacctt ccgtgttcct gtttcctcct aagcccaagg acaccctgat gatctctcgg       900
acccctgagg tgacctgcgt ggtggtggac gtgtctcatg aggatcctga agtgaagttc       960
aactggtacg tggatggcgt ggaagtgcac aacgccaaga ccaagcctag agaagaacag      1020
tacaactcca cctacagagt ggtcagcgtg ctgaccgtgc tgcatcagga ctggctgaac      1080
ggaaaagagt acaagtgcaa ggtgtccaac aaggctctgg ctgcccctat cgagaagacc      1140
atctccaagg ccaagggcca gccccgcgag cctcaggtgt gcaccctgcc tccatctaga      1200
gaagagatga ccaagaacca ggtctccctc agctgcgccg tgaagggctt ctacccttct      1260
gacatcgctg tggaatggga aagcaatggc caacccgaga acaactacaa gaccaccccc      1320
cctgtgctgg actccgacgg cagcttcttc ctggtgtcaa agctgacagt ggacaagtcc      1380
agatggcagc agggcaacgt gttcagctgc agtgtgatgc acgaggccct gcacaaccac      1440
tacacccaga aatctctgtc tctgtctcct ggcaaa                                1476

<210>  67
<211>  482
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-scFv-Fc


<400>  67
Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Val 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
        115                 120                 125             
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 
Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn Trp 
145                 150                 155                 160 
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
                165                 170                 175     
Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
            180                 185                 190         
Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
        195                 200                 205             
Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg 
    210                 215                 220                 
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly 
225                 230                 235                 240 
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Glu Pro Lys Ser Ser Asp 
                245                 250                 255     
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
            260                 265                 270         
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu 
        355                 360                 365             
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 
Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 
Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 
Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 
Gly Lys 
        

<210>  68
<211>  1446
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-scFv-Fc


<400>  68
gagctggtcg tcacccaaga gccctctctg accacaagcc ctggcggaac cgtgaccctg        60
acctgtaggt cctccaccgg cgctgtgacc acctcgaact atgccaactg ggtgcaacag       120
aagcccggcc aggcacccag aggcctgatc ggcggcacca acaagcgcgc ccccggcaca       180
cctgccagat tctctggctc tctgctgggc ggaaaggccg ccctgaccat caccggcgtc       240
cagcccgagg acgaggccga gtactactgc gctctgtggt actccaacct gtgggtgttt       300
ggcggcggca ccaagctgac cgtgctgggc ggcggtggct ctggaggagg cggatctggt       360
ggcggaggct ctgaagtgca gctcgttgag agcggcggcg gcctggtgca gcctggcggc       420
tccctgagac tgtcttgcgc cgcttccggc ttcaccttca acacctatgc catgaattgg       480
gtccggcagg cccccggcaa gggactggaa tgggtggcta gaatcagatc caagtacaac       540
aactacgcta cctactacgc cgactctgtg aaggaccggt tcaccatctc tcgggacgac       600
tccaagaaca ccgcctacct gcagatgaac aatctgaaga ccgaggatac cgctatgtac       660
tactgtgtgc ggcacggcaa cttcggcaac tcctacgtgt cctggttcgc ctactggggc       720
cagggcactc tcgtgaccgt gtccagcggc gagcccaagt cctctgacaa gacccacacc       780
tgccctccat gtcctgctcc tgaggctgct ggcggccctt ccgtgtttct gttccctcct       840
aagcctaaag atacactgat gatctcccgg acccctgaag ttacatgcgt ggtggtggac       900
gtgtctcacg aggaccccga agtgaagttc aactggtatg tggatggcgt ggaagtgcac       960
aatgccaaaa ccaagcctcg ggaggaacag tacaactcta cctacagagt ggtaagcgtg      1020
ctgaccgtgc tgcaccagga ctggctgaac ggcaaagagt acaagtgcaa ggtgtctaac      1080
aaggctctgg ccgcccctat cgagaagaca atttccaagg ccaagggcca gcctagagaa      1140
cctcaggtgt acaccctgcc tccttgcaga gaagagatga ccaagaacca ggttagccta      1200
tggtgcctgg tgaagggttt ctacccttct gacatcgccg tggagtggga gtccaatggc      1260
caaccagaga acaactacaa gacaacacca cctgtgctgg actccgatgg ctccttcttc      1320
ctgtactcta agctgacagt ggacaagtcc agatggcagc agggcaacgt gttctcctgc      1380
tccgtgatgc atgaagctct gcacaaccgg ttcacccaga aatccctgag cctgtctcct      1440
ggaaaa                                                                 1446

<210>  69
<211>  356
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A10-v1-Fc


<400>  69
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Glu Pro Lys Ser 
        115                 120                 125             
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    130                 135                 140                 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro 
225                 230                 235                 240 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     
Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         
Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
305                 310                 315                 320 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         
Ser Pro Gly Lys 
        355     

<210>  70
<211>  1068
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A10-v1-Fc


<400>  70
caagtccagc tggttgagtc cggcggaggc ctggtgcagc caggcggctc cctgagactg        60
tcttgtgctg cctctggcta ctcctctaat gtggcctgca tggcctggta ccggcaggcc       120
cctggcaagg gcctggaatg ggtggctact atcgtggccg acttcggcac caccaattat       180
gctgcctctg tgaagggacg gttcaccatc tcccaggaca actccaagaa caccgtgtac       240
ctgcagatga acagcctgcg ggccgaggac acagccgtgt actactgtgc cgctacacag       300
agaggcggca tcgactggtg cgacgagatc aactactggg gccaaggaac cctggtgaca       360
gtgtcttctg gcgagcccaa atcctccgat aaaacacaca cctgtcctcc ttgccctgct       420
cccgaggccg ccggcggccc tagcgtattc ctgtttcccc ctaagcctaa ggacacattg       480
atgatctctc ggacacccga agtgacctgc gtggtcgtgg acgtgtctca cgaagatcct       540
gaggtgaagt tcaactggta tgtggatggc gtggaagtgc ataacgccaa gaccaagccc       600
agagaggaac agtacaactc tacctacaga gtggtgtccg tcctgaccgt gctgcatcag       660
gattggctga acggcaaaga gtacaagtgc aaggtgtcta acaaggctct ggccgctccc       720
attgagaaga ccatctccaa ggctaagggt cagcctagag agcctcaagt gtgcaccctg       780
cctccatcta gagaagagat gaccaagaac caggtcagcc tgtcttgtgc agtgaaaggc       840
ttctacccaa gcgacatcgc cgtggaatgg gagtctaatg gccagcctga aaacaactac       900
aagaccaccc ctcctgtgct cgactccgac ggctccttct tcctggtgtc caagctgacc       960
gtggacaagt cccgctggca gcagggcaac gtgttctcct gctccgtgat gcacgaggct      1020
ctgcacaacc actacaccca gaagagcctg agcctgtccc ctggaaag                   1068

<210>  71
<211>  613
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A11-v1-linker-anti-CD3-scFv-Fc


<400>  71
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              
Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser 
    130                 135                 140                 
Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
145                 150                 155                 160 
Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     
Pro Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro 
            180                 185                 190         
Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile 
        195                 200                 205             
Thr Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp 
    210                 215                 220                 
Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
                245                 250                 255     
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            260                 265                 270         
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala 
        275                 280                 285             
Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
    290                 295                 300                 
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
305                 310                 315                 320 
Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 
                325                 330                 335     
Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr 
            340                 345                 350         
Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala 
        355                 360                 365             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Glu Pro Lys 
    370                 375                 380                 
Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
385                 390                 395                 400 
Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                405                 410                 415     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            420                 425                 430         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        435                 440                 445             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    450                 455                 460                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
465                 470                 475                 480 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala 
                485                 490                 495     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            500                 505                 510         
Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr Lys Asn Gln 
        515                 520                 525             
Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    530                 535                 540                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
545                 550                 555                 560 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                565                 570                 575     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            580                 585                 590         
Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
        595                 600                 605             
Leu Ser Pro Gly Lys 
    610             

<210>  72
<211>  1839
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A11-v1-linker-anti-CD3-scFv-Fc


<400>  72
caggtgcagc tcgtggaatc cggcggcggc ctggtgcagc ctggcggctc tctgagactg        60
tcttgtgctg cctctggctt tactttcaac tccgcctgca tgggctggtt cagacaggcc       120
cccggaaagg gccgggaggg cgtgtctcgg atcgagacag gctacggcgg taccgtgtac       180
gccgactctg tgaaaggcag attcaccatc tccagagaca actccaagaa taccgtctac       240
ctgcagatga atagcctccg cgccgaggac accgctgtgt actactgcgc cgctaagaga       300
tcttggtgca cccccacctg gtggcacgag ctggactaca actactgggg ccagggaacc       360
caggtgaccg tgtccagcgg cggaggcggc tctgaactgg tggtgaccca agagccttcc       420
ctgaccacct cccctggcgg cacagtgaca ctgacctgta gatcctccac cggcgccgtg       480
accacctcta actatgctaa ctgggtgcag cagaaacctg gccaggcacc tcggggactg       540
atcggcggca ccaacaagcg ggctcctgga acacctgcta gattctccgg ctccttgctg       600
ggcggcaagg ccgccctgac catcaccggg gtgcaacctg aggacgaggc tgagtattac       660
tgcgctctgt ggtactccaa cctgtgggtc tttggcggcg gaaccaagct gaccgtgctg       720
ggcggcggcg gctccggcgg aggcggctcc ggaggaggcg gcagcgaggt gcagctggtc       780
gagtctggcg gcggcctggt gcagcccggc ggctcgctgc ggctgagctg tgccgcctcc       840
ggcttcacat tcaataccta cgccatgaac tgggtcaggc aggctcctgg caaaggcctg       900
gaatgggtgg ccagaatccg gagcaagtac aacaactatg ccacctacta cgccgattct       960
gtgaaggaca gattcacaat ctcccgggac gactctaaga acaccgctta cctgcagatg      1020
aacaacctga agaccgagga tacagctatg tactactgtg tgcggcacgg caacttcggc      1080
aattcctacg tgtcctggtt cgcctactgg ggacaaggca ccttggtgac agtttctagc      1140
ggcgagccca agtcttctga caagacacac acctgccctc cttgtcctgc ccctgaggcc      1200
gctggcggac cttctgtgtt tctgtttcca cctaagccta aggataccct gatgatctct      1260
agaacccccg aggtgacctg cgtggtcgtg gacgtgagcc atgaagatcc tgaagtgaag      1320
ttcaactggt atgtggacgg cgtggaagtg cacaatgcca agaccaagcc tagagaagag      1380
cagtacaact ctacctacag agtggtgtcc gtgctgaccg ttctgcatca ggactggctg      1440
aacggcaaag agtacaagtg caaggtgtct aacaaggctc tggctgcccc tatcgagaag      1500
accatttcca aggccaaggg ccagccacgc gaacctcaag tgtacaccct gccaccttgc      1560
agagaggaga tgaccaagaa ccaggtgagc ctgtggtgcc tggtgaaagg cttctacccc      1620
agcgacatcg ccgtggaatg ggagtccaac ggccagcccg agaacaacta caaaaccacc      1680
cctcctgtgc tggattctga tggttccttc ttcctgtact ctaagctgac cgtggacaag      1740
tcccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaagc cctgcacaac      1800
cggttcaccc agaaatccct gtctctgtct ccaggcaag                             1839

<210>  73
<211>  359
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A11-v1-Fc


<400>  73
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Ala 
            20                  25                  30          
Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              
Ser Arg Ile Glu Thr Gly Tyr Gly Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Ser Trp Cys Thr Pro Thr Trp Trp His Glu Leu Asp 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Glu 
        115                 120                 125             
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 
Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 
Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     
Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            260                 265                 270         
Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
305                 310                 315                 320 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         
Leu Ser Leu Ser Pro Gly Lys 
        355                 

<210>  74
<211>  1077
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A11-v1-Fc


<400>  74
caggtgcagc tggtggaatc cggcggaggc ctggtccagc ctggaggcag cctgcggctg        60
tcgtgcgctg cctccggatt caccttcaac tccgcctgta tgggctggtt cagacaggcc       120
cctggcaagg gtcgcgaggg cgttagccgg atcgaaacag gctacggcgg aaccgtctac       180
gccgactccg tgaaaggcag attcaccatc tctcgggaca attctaagaa taccgtgtac       240
ctgcagatga actctctgag ggccgaggac accgctgtgt actactgcgc cgctaaacgg       300
tcctggtgca ctcctacctg gtggcatgag ctggactaca attattgggg ccaaggaaca       360
caagtgacag tatcctctgg cgagcccaag tcctccgata aaacccacac ctgccctcct       420
tgtcctgctc cagaggccgc tggcggccct tccgtgtttc tgtttccacc taagcccaag       480
gacacactga tgatcagcag aacccctgaa gtcacctgtg tggtcgtgga cgtgagccat       540
gaagatcctg aggtgaagtt caactggtac gtggacggcg tggaagtgca caacgctaaa       600
accaagccta gagaggaaca gtacaactct acctacagag tggtgtccgt gctgacagtg       660
ctgcaccagg actggctgaa cggcaaagag tacaagtgca aggtgagtaa caaggccctg       720
gctgctccca tcgagaagac catctccaag gccaagggcc agcctcggga gcctcaggtg       780
tgcaccctgc ctccatctag agaagagatg accaagaacc aggtgtccct gtcttgtgcc       840
gtcaagggct tctacccttc tgacatcgcc gtggaatggg agtctaacgg ccagcccgag       900
aacaactata agaccacccc ccccgtgctg gattctgatg gctccttctt cctcgtgtcc       960
aagctgaccg tggacaagtc cagatggcag cagggcaacg tgttctcctg ctctgtgatg      1020
cacgaggcac tgcacaacca ctacacccag aagtccctta gcctgtctcc tggcaag         1077

<210>  75
<211>  343
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A10-v1-linker-anti-CD3-VL


<400>  75
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ser Asn Val Ala 
            20                  25                  30          
Cys Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Val Ala Asp Phe Gly Thr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Thr Gln Arg Gly Gly Ile Asp Trp Cys Asp Glu Ile Asn Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Thr Ser Pro Gly Gly 
    130                 135                 140                 
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
145                 150                 155                 160 
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly 
                165                 170                 175     
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
            180                 185                 190         
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Thr Gly Val 
        195                 200                 205             
Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
    210                 215                 220                 
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
225                 230                 235                 240 
Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
                245                 250                 255     
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
            260                 265                 270         
Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala 
        275                 280                 285             
Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
    290                 295                 300                 
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
305                 310                 315                 320 
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
                325                 330                 335     
Val Ala Pro Thr Glu Cys Ser 
            340             

<210>  76
<211>  1029
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-A10-v1-linker-anti-CD3-VL


<400>  76
caagtgcagc tggtggaatc tggcggcgga ctggtgcagc caggcggctc cctgagactg        60
tcctgtgctg cttctggcta ctcgtccaac gtggcctgca tggcctggta tcgccaggct       120
cctggcaaag gcctggaatg ggtggctacc atcgtggccg acttcggcac tacaaactac       180
gccgcctccg tgaagggcag attcaccatc tctcaggaca actccaagaa caccgtgtac       240
ctgcagatga acagcctgcg ggctgaggac accgccgtgt actactgtgc cgctacccag       300
cggggaggca tcgactggtg cgacgagatc aactactggg gccagggaac cttggttaca       360
gtgtccagcg gcggaggcgg ctccgaactg gtggtgaccc aagagccttc tctgaccacc       420
tcccctggcg gcacagtgac cctgacctgt agatcctcta ccggtgccgt gacaacctct       480
aattacgcca actgggtcca gcagaagccc ggccaagccc ctagaggcct gatcggcggg       540
acgaacaagc gggctcctgg cacccctgcc cggttcagcg gctctctgct gggcggcaag       600
gctgccctga caatcaccgg cgtgcagcct gaggatgagg ccgagtacta ctgcgctctg       660
tggtatagca acctgtgggt gttcggagga ggcacaaagc tgaccgtgct gggccagcct       720
aaggccaatc ctaccgtgac cctgtttcct ccatcttctg aagagctgca ggccaacaaa       780
gccaccctcg tgtgcctgat ctccgacttc taccccggcg ctgtgaccgt ggcatggaag       840
gccgatggct cccctgtgaa agctggcgtc gaaaccacca agcctagcaa gcagtccaac       900
aacaagtacg ctgcctcttc ctacctgtct ctgacccccg agcagtggaa gtcccataga       960
agctactctt gccaggtgac ccacgagggc tccaccgtcg agaagaccgt ggcccccacc      1020
gagtgctcc                                                              1029

<210>  77
<211>  446
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-HC-Fc


<400>  77
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210>  78
<211>  1338
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-HC-Fc


<400>  78
gaggtgcagc tgctggaatc tggaggcggc ctggtgcaac ccggcggatc tctgagactg        60
tcttgtgccg cttctggctt caccttttcc tcctacgcca tgtcctgggt cagacaggcc       120
cctggaaagg gactggaatg ggtgtctgcc atctccggct ctggcggctc tacatactac       180
gccgacagcg tgaagggcag attcaccatc agccgggaca actccaagaa caccctctac       240
ctgcagatga actctctgcg ggccgaggat accgccgtgt actactgcgc caaagtgctg       300
ggatggttcg actactgggg ccaaggcacg ctcgtgaccg tgtcctccgc ctccaccaaa       360
ggaccttccg tgtttcctct ggccccttcc agcaagtcca cctccggcgg taccgctgcc       420
ctgggctgcc tggtcgagga ctacttccct gagcccgtga ccgtgtcttg gaactccggc       480
gctctgacct ctggcgtgca caccttcccc gctgttctgc agtccagcgg cctgtactcc       540
ctgtcctctg tggtgacagt gcctagctct tctctgggca cccagaccta catctgcaac       600
gtgaaccaca agccctccaa caccaaggtg gatgagaaag tggaacccaa gtcttgcgac       660
aagacacata cctgtcctcc ttgccctgct cctgaggccg ctggcggccc ttctgtgttc       720
ctgttcccac ccaagcctaa ggacaccctg atgatctctc ggacccctga ggtcacctgc       780
gtggtcgtgg acgtgtccca tgaagatcct gaagtgaagt tcaactggta cgtggatggc       840
gtggaagtgc acaacgccaa gaccaagcct cgggaagagc agtacaactc cacatacaga       900
gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc       960
aaggtgtcca acaaggctct cggcgccccc atcgagaaga caatctccaa ggccaagggc      1020
cagcctagag agcctcaggt gtgcaccctg cctccatctc gcgacgagct gactaagaac      1080
caggtgtccc tgtcctgtgc tgtgaaaggc ttctaccctt ctgacatcgc cgtggagtgg      1140
gagtctaacg gccagcccga gaacaactac aagaccacac ctcctgttct ggactccgac      1200
ggctccttct tcctggtgtc taagctgacc gtggacaagt ccagatggca gcagggcaac      1260
gtgttctcct gctccgtgat gcacgaggct ctgcacaaca gattcaccca gaagtctctc      1320
agcctgtccc ctggcaag                                                    1338

<210>  79
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-LC


<400>  79
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Tyr Pro Pro 
                85                  90                  95      
Asp Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg Lys Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  80
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-LC


<400>  80
gagatcgtgc tgacccagtc tcctggaaca ctgtctctgt cccctggcga gagagctacc        60
ctgagctgca gagcctctca gtccgtgtcc tcctcctacc tggcctggta ccagcagaag       120
cctggccagg cccctcggct gctgatctac ggcgctagct ctcgggccac cggcatccct       180
gacagattct ccggctccgg ctctggcaca gattttaccc tgaccatctc cagactggaa       240
cctgaggact tcgccgtgta ctactgccag cagtacggct acccccccga cttcaccttc       300
ggccaaggca ccaaagtgga aatcaagcgg accgtggctg ctccttctgt gttcatcttc       360
cctccttccg accggaagct gaagtctgga accgcctccg tggtgtgcct gctgaacaac       420
ttctacccta gagaggccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaac       480
tcccaagagt ccgtcaccga gcaggactct aaggactcca cctactccct gtcctctacc       540
ctgacactgt ccaaggccga ctacgagaag cacaaggtgt acgcctgcga ggtgacccac       600
cagggcctgt cttctcctgt gaccaagtcc ttcaacagag gcgaatgt                    648

<210>  81
<211>  671
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-VH-anti-CD3-VL-Fc


<400>  81
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Val Leu Gly Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 
Ser Gly Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu 
225                 230                 235                 240 
Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr 
                245                 250                 255     
Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro 
            260                 265                 270         
Gly Gln Ala Phe Arg Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro 
        275                 280                 285             
Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala 
    290                 295                 300                 
Leu Thr Leu Ser Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys 
305                 310                 315                 320 
Ala Leu Trp Tyr Ser Asn Leu Trp Val Phe Gly Gly Gly Thr Lys Leu 
                325                 330                 335     
Thr Val Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
            340                 345                 350         
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
        355                 360                 365             
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
    370                 375                 380                 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
385                 390                 395                 400 
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
                405                 410                 415     
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
            420                 425                 430         
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
        435                 440                 445             
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
    450                 455                 460                 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
465                 470                 475                 480 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                485                 490                 495     
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            500                 505                 510         
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        515                 520                 525             
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    530                 535                 540                 
Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
545                 550                 555                 560 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                565                 570                 575     
Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
            580                 585                 590         
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        595                 600                 605             
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    610                 615                 620                 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
625                 630                 635                 640 
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                645                 650                 655     
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665                 670     

<210>  82
<211>  2013
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-BCMA-VH-anti-CD3-VL-Fc


<400>  82
gaggtgcagc tgctggaatc aggcggaggc ctcgtgcagc caggtggcag cctgcggctg        60
tcttgtgccg cctctggctt caccttctcc tcctacgcca tgtcctgggt gcggcaggcc       120
cctggcaagg gactggagtg ggtctccgcc atctctgggt ccggaggctc cacctactac       180
gctgattctg tgaaaggcag attcaccatc tctcgggaca actccaagaa cacactgtac       240
ctgcagatga actccctgag agccgaggac accgccgtgt actactgcgc caaggtgctg       300
ggatggttcg actactgggg ccagggcacc ttagtgaccg tgtcaagcgc cagcacaaag       360
ggacctagcg tatttcctct ggcccctagc tctaagtcca cctctggtgg caccgcagcc       420
ctgggctgtc tggtggaaga ctacttccct gaacccgtga cagtgtcttg gaactccggc       480
gctctgacat ctggcgtgca caccttccct gctgttcttc aatcttccgg cctgtacagc       540
ctgtcctctg ttgtcacagt gcccagttct tctctgggca cccagacata catctgtaac       600
gtgaaccaca agccttccaa caccaaagtg gacgagaaag tggaacctaa gtcctgcgat       660
ggcggcggcg ggtccggtgg agggggatct caggctgtgg tcacccaaga gccctccctg       720
accgtgtccc ctggcggcac cgtgacactg acctgcggct cttccacagg cgccgtgacc       780
acctccaact acgccaactg ggtgcaagag aagcctggcc aggccttcag aggcctgatc       840
ggcggaacca acaagcgggc tcctggcacc cctgccagat tctctggaag tctgctgggt       900
ggcaaggctg cactgaccct gtccggcgct caacctgagg atgaggccga gtactactgc       960
gccctgtggt attccaacct gtgggtcttc ggcggtggca ccaagctgac cgtgctgtct      1020
tctgcctcca ccaaaggccc ctcggtgttc cctctggctc ctagttccaa gtctacctcc      1080
ggcggtacag ctgctctggg ctgcctggtc aaggattact tcccagagcc tgtgaccgtg      1140
tcttggaact cgggcgccct gacttctgga gtgcacacat tccctgctgt gctgcagtcc      1200
tctggcctgt actctctgtc ttcggtcgtg acagtgcctt ccagcagcct cggcacacag      1260
acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggataa gaaggtggaa      1320
cccaaatctt gcgacaagac ccacacctgt cctccttgtc ctgcccctga ggccgctggc      1380
ggcccttctg tgttcctgtt cccgccaaag cctaaggaca cgctgatgat ctcccggacc      1440
cctgaggtga cctgcgtggt ggtggatgtg tctcatgagg accctgaagt gaagttcaac      1500
tggtacgtgg acggcgtcga ggtgcacaac gccaaaacca agcccagaga ggaacagtac      1560
aacagcacct acagagtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      1620
aaagagtaca agtgcaaggt gagcaataag gccctgggcg cccctatcga gaagaccatc      1680
tccaaggcca agggccagcc tagagaacct caggtgtaca ccctgcctcc ttgcagagac      1740
gagctgacca agaaccaggt ctctctgtgg tgcctggtga agggcttcta cccttctgac      1800
atcgccgtgg aatgggagtc caatggacag cccgagaaca actacaagac cacacctcca      1860
gtgctggact ccgacggctc cttcttcctg tacagcaagc tgacagtgga caagtccaga      1920
tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggctctgca caaccactac      1980
acccagaagt ccctgtccct gtctcctgga aag                                   2013

<210>  83
<211>  232
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-VH-CL


<400>  83
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val 
        115                 120                 125             
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 
Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         

<210>  84
<211>  696
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  anti-CD3-VH-CL


<400>  84
gaggtgcagc tgctggaatc cggcggagga ctggtccagc ctggcggctc tctgcggctg        60
tcttgtgctg cttctggctt caccttctcc acatatgcca tgaactgggt cagacaggcc       120
cccggcaagg gcctggaatg ggtgtccaga atcagatcca agtacaacaa ctacgccacc       180
tactacgccg attccgtgaa gggacggttc accatctccc gggacgactc caagaacaca       240
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ctgcgtgcgg       300
cacggcaact tcggcaattc ctacgtgtcc tggttcgcct actggggcca gggcaccctg       360
gtcaccgtgt cttccgcctc tgtggccgct ccttctgtgt tcatcttccc tccttccgac       420
gagcagctga agtctggcac agcttctgtg gtgtgcctgc tgaacaactt ctaccctaga       480
gaggccaagg tgcagtggaa ggtggacaac gccctgcagt ccggcaactc ccaagagtcc       540
gtgaccgagc aggactctaa ggactctacc tactccctgt cctccaccct gaccctgagc       600
aaggccgact acgagaagca caaagtgtac gcctgcgaag tgacccacca gggcctgtcc       660
tctcctgtga ccaagtcctt caacagaggc gagtgc                                 696

