﻿                         序列表

<110>  南京北恒生物科技有限公司

<120>  工程化免疫细胞及其用途

<130>  BHCN36V1

<150>  2021104104669
<151>  2021-04-16

<160>  36

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  726
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD19 scFv


<400>  1
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc        60
atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca       120
gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca       180
aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa       240
gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg       300
gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc       360
ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg       420
tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc       480
cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac       540
tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt       600
ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat       660
tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc       720
tcctca                                                                  726

<210>  2
<211>  242
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD19 scFv


<400>  2
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             
Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 
Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 
Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     
Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         
Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             
Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 
Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 
Ser Ser 
        

<210>  3
<211>  75
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α跨膜结构域


<400>  3
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc        60
accctttact gcaaa                                                         75

<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α跨膜结构域


<400>  4
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            20                  25  

<210>  5
<211>  120
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  4-1BB共刺激结构域


<400>  5
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact        60
actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa       120

<210>  6
<211>  40
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  4-1BB共刺激结构域


<400>  6
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
1               5                   10                  15      
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            20                  25                  30          
Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40  

<210>  7
<211>  339
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  7
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag        60
ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt       120
ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac       180
aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag       240
cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac       300
acctacgacg cccttcacat gcaggccctg ccccctcgc                              339

<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  8
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210>  9
<211>  63
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α信号肽


<400>  9
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccg                                                                      63

<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α信号肽


<400>  10
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210>  11
<211>  135
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α铰链区


<400>  11
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg        60
tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg       120
gacttcgcct gtgat                                                        135

<210>  12
<211>  45
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α铰链区


<400>  12
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  13
<211>  714
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD19 scFv


<400>  13
gacatccaga tgacccagag ccctgccagc ctgtctacca gcctgggcga gacagtgacc        60
atccagtgtc aggccagcga ggacatctac tctggcctgg cttggtatca gcagaagccc       120
ggcaagagcc ctcagctgct gatctacggc gccagcgacc tgcaggacgg cgtgcctagc       180
agattcagcg gcagcggctc cggaacccag tacagcctga agatcaccag catgcagacc       240
gaggacgagg gcgtgtactt ctgccagcaa ggcctgacct accctagaac cttcggagga       300
ggcaccaagc tggaactgaa gggcggaggc ggaagtggag gcggaggatc tggcggcgga       360
ggctctgaag tgcagctgca gcagtctggc gctgaactgg tccggcctgg cactagcgtg       420
aagctgtcct gcaaggtgtc cggcgacacc atcaccttct actacatgca cttcgtgaag       480
cagaggccag gacagggcct ggaatggatc ggcagaatcg accctgagga cgagagcacc       540
aagtacagcg agaagttcaa gaacaaggcc accctgaccg ccgacaccag cagcaacacc       600
gcctacctga agctgtctag cctgacctcc gaggacaccg ccacctactt ttgcatctac       660
ggcggctact acttcgacta ctggggccag ggcgtgatgg tcaccgtgtc cagc             714

<210>  14
<211>  238
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD19 scFv


<400>  14
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr 
65                  70                  75                  80  
Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
        115                 120                 125             
Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
    130                 135                 140                 
Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val Lys 
145                 150                 155                 160 
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu 
                165                 170                 175     
Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr Leu 
            180                 185                 190         
Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser Leu 
        195                 200                 205             
Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr Tyr 
    210                 215                 220                 
Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
225                 230                 235             

<210>  15
<211>  63
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α跨膜结构域


<400>  15
atctgggcac ccttggccgg aatctgcgtg gcccttctgc tgtccttgat catcactctc        60
atc                                                                      63

<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α跨膜结构域


<400>  16
Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      
Ile Ile Thr Leu Ile 
            20      

<210>  17
<211>  126
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  m4-1BB共刺激结构域


<400>  17
aggaaaaaat tcccccacat attcaagcaa ccatttaaga agaccactgg agcagctcaa        60
gaggaagatg cttgtagctg ccgatgtcca caggaagaag aaggaggagg aggaggctat       120
gagctg                                                                  126

<210>  18
<211>  42
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  m4-1BB共刺激结构域


<400>  18
Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr 
1               5                   10                  15      
Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu 
            20                  25                  30          
Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
        35                  40          

<210>  19
<211>  327
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD3ζ胞内信号传导结构域


<400>  19
agcaggagtg cagagactgc tgccaacctg caggacccca accagctcta caatgagctc        60
aatctagggc gaagagagga atatgacgtc ttggagaaga agcgggctcg ggatccagag       120
atgggaggca aacagcagag gaggaggaac ccccaggaag gcgtatacaa tgcactgcag       180
aaagacaaga tggcagaagc ctacagtgag atcggcacaa aaggcgagag gcggagaggc       240
aaggggcacg atggccttta ccagggtctc agcactgcca ccaaggacac ctatgatgcc       300
ctgcatatgc agaccctggc ccctcgc                                           327

<210>  20
<211>  109
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD3ζ胞内信号传导结构域


<400>  20
Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu 
1               5                   10                  15      
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu 
            20                  25                  30          
Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg 
        35                  40                  45              
Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met 
    50                  55                  60                  
Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly 
65                  70                  75                  80  
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                85                  90                  95      
Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
            100                 105                 

<210>  21
<211>  135
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α铰链区


<400>  21
actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag        60
ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttc       120
gcctgtgata tttac                                                        135

<210>  22
<211>  45
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α铰链区


<400>  22
Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
1               5                   10                  15      
Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
            20                  25                  30          
Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45  

<210>  23
<211>  345
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL-1


<400>  23
atgagacttc tcatcctggc cctccttggc atctgctctc tcactgcata cattgtggaa        60
ggtgtaggga gtgaagtctc agataagagg acctgtgtga gcctcactac ccagcgactg       120
ccggttagca gaatcaagac ctacaccatc acggaaggct ccttgagagc agtaattttt       180
attaccaaac gtggcctaaa agtctgtgct gatccacaag ccacgtgggt gagagacgtg       240
gtcaggagca tggacaggaa atccaacacc agaaataaca tgatccagac caagccaaca       300
ggaacccagc aatcgaccaa tacagctgtg accctgactg gctag                       345

<210>  24
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL-1


<400>  24
Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      
Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser Asp Lys Arg Thr Cys 
            20                  25                  30          
Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              
Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  
Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  
Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      
Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         
Thr Gly 
        

<210>  25
<211>  345
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mXCL-1


<400>  25
atgagacttc tcctcctgac tttcctggga gtctgctgcc tcaccccatg ggttgtggaa        60
ggtgtgggga ctgaagtcct agaagagagt agctgtgtga acttacaaac ccagcggctg       120
ccagttcaaa aaatcaagac ctatatcatc tgggaggggg ccatgagagc tgtaattttt       180
gtcaccaaac gaggactaaa aatttgtgct gatccagaag ccaaatgggt gaaagcagcg       240
atcaagactg tggatggcag ggccagtacc agaaagaaca tggctgaaac tgttcccaca       300
ggagcccaga ggtccaccag cacagcagta accctgactg ggtaa                       345

<210>  26
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mXCL-1


<400>  26
Met Arg Leu Leu Leu Leu Thr Phe Leu Gly Val Cys Cys Leu Thr Pro 
1               5                   10                  15      
Trp Val Val Glu Gly Val Gly Thr Glu Val Leu Glu Glu Ser Ser Cys 
            20                  25                  30          
Val Asn Leu Gln Thr Gln Arg Leu Pro Val Gln Lys Ile Lys Thr Tyr 
        35                  40                  45              
Ile Ile Trp Glu Gly Ala Met Arg Ala Val Ile Phe Val Thr Lys Arg 
    50                  55                  60                  
Gly Leu Lys Ile Cys Ala Asp Pro Glu Ala Lys Trp Val Lys Ala Ala 
65                  70                  75                  80  
Ile Lys Thr Val Asp Gly Arg Ala Ser Thr Arg Lys Asn Met Ala Glu 
                85                  90                  95      
Thr Val Pro Thr Gly Ala Gln Arg Ser Thr Ser Thr Ala Val Thr Leu 
            100                 105                 110         
Thr Gly 
        

<210>  27
<211>  54
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  T2A


<400>  27
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct              54

<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  T2A


<400>  28
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      
Gly Pro 
        

<210>  29
<211>  72
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α信号肽


<400>  29
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt        60
atcctgggga gt                                                            72

<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α信号肽


<400>  30
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      
Gly Glu Ser Ile Ile Leu Gly Ser 
            20                  

<210>  31
<211>  345
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL2


<400>  31
atgagacttc tcatcctggc cctccttggc atctgctctc tcactgcata cattgtggaa        60
ggtgtaggga gtgaagtctc acataggagg acctgtgtga gcctcactac ccagcgactg       120
ccagttagca gaatcaagac ctacaccatc acggaaggct ccttgagagc agtaattttt       180
attaccaaac gtggcctaaa agtctgtgct gatccacaag ccacgtgggt gagagacgtg       240
gtcaggagca tggacaggaa atccaacacc agaaataaca tgatccagac caagccaaca       300
ggaacccagc aatcgaccaa tacagctgtg accctgactg gctag                       345

<210>  32
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL2


<400>  32
Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      
Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser His Arg Arg Thr Cys 
            20                  25                  30          
Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              
Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  
Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  
Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      
Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         
Thr Gly 
        

<210>  33
<211>  122
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  Claudin18.2 sdAb


<400>  33
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Leu Ile Asn 
            20                  25                  30          
Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Val Ile Thr Arg Gly Gly Ser Ala Asn Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Asp Leu Asn Leu Arg Ser Asp Pro Phe Lys Trp Tyr Thr Phe Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CLDN18.2 sdAb CDR1


<400>  34
Gly Ser Ile Phe Leu Ile Asn 
1               5           

<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CLDN18.2 sdAb CDR2


<400>  35
Thr Arg Gly Gly Ser 
1               5   

<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CLDN18.2 sdAb CDR3


<400>  36
Asp Leu Asn Leu Arg Ser Asp Pro Phe Lys Trp Tyr Thr Phe 
1               5                   10                  

