                               SEQUENCE LISTING

<110> GENOMATICA, INC.
 
<120> PHOSPHOKETOLASE VARIANTS AND METHODS OF USE

<130> 199683-228509/PCT

<140>
<141>

<150> 63/173,217
<151> 2021-04-09

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 826
<212> PRT
<213> Bifidobacterium adolescentis

<400> 1
Met Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala 
1               5                   10                  15      


Pro Val Ser Glu Glu Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Ala 
            20                  25                  30          


Ala Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu 
        35                  40                  45              


Met Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly 
    50                  55                  60                  


His Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn 
65                  70                  75                  80  


Arg Leu Ile Ala Asp His Gln Gln Asn Thr Val Ile Ile Met Gly Pro 
                85                  90                  95      


Gly His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr 
            100                 105                 110         


Tyr Thr Glu Tyr Phe Pro Asn Ile Thr Lys Asp Glu Ala Gly Leu Gln 
        115                 120                 125             


Lys Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Tyr 
    130                 135                 140                 


Ala Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr 
145                 150                 155                 160 


Ala Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe 
                165                 170                 175     


Val Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala 
            180                 185                 190         


Thr Gly Trp Gln Ser Asn Lys Leu Ile Asn Pro Arg Thr Asp Gly Ile 
        195                 200                 205             


Val Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr 
    210                 215                 220                 


Ile Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly 
225                 230                 235                 240 


Met Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asn Glu Asp 
                245                 250                 255     


His Leu Ser Ile His Arg Arg Phe Ala Glu Leu Phe Glu Thr Val Phe 
            260                 265                 270         


Asp Glu Ile Cys Asp Ile Lys Ala Ala Ala Gln Thr Asp Asp Met Thr 
        275                 280                 285             


Arg Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr 
    290                 295                 300                 


Cys Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ser 
305                 310                 315                 320 


His Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu 
                325                 330                 335     


Val Leu Lys Asn Trp Leu Glu Ser Tyr Lys Pro Glu Glu Leu Phe Asp 
            340                 345                 350         


Glu Asn Gly Ala Val Lys Pro Glu Val Thr Ala Phe Met Pro Thr Gly 
        355                 360                 365             


Glu Leu Arg Ile Gly Glu Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg 
    370                 375                 380                 


Glu Glu Leu Lys Leu Pro Lys Leu Glu Asp Tyr Glu Val Lys Glu Val 
385                 390                 395                 400 


Ala Glu Tyr Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu 
                405                 410                 415     


Gly Val Tyr Thr Arg Asp Ile Ile Lys Asn Asn Pro Asp Ser Phe Arg 
            420                 425                 430         


Ile Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr 
        435                 440                 445             


Asp Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Ala Gln Val 
    450                 455                 460                 


Asp Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu 
465                 470                 475                 480 


His Gln Met Glu Gly Phe Leu Glu Gly Tyr Leu Leu Thr Gly Arg His 
                485                 490                 495     


Gly Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met 
            500                 505                 510         


Leu Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro 
        515                 520                 525             


Trp Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val 
    530                 535                 540                 


Trp Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr 
545                 550                 555                 560 


Ser Val Leu Leu Asn Lys Cys Phe Asn Asn Asp His Val Ile Gly Ile 
                565                 570                 575     


Tyr Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Ala Glu Lys Cys 
            580                 585                 590         


Tyr Lys Ser Thr Asn Lys Ile Asn Ala Ile Ile Ala Gly Lys Gln Pro 
        595                 600                 605             


Ala Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Ala Glu Leu Glu Lys 
    610                 615                 620                 


Gly Ala Ala Glu Trp Lys Trp Ala Ser Asn Val Lys Ser Asn Asp Glu 
625                 630                 635                 640 


Ala Gln Ile Val Leu Ala Ala Thr Gly Asp Val Pro Thr Gln Glu Ile 
                645                 650                 655     


Met Ala Ala Ala Asp Lys Leu Asp Ala Met Gly Ile Lys Phe Lys Val 
            660                 665                 670         


Val Asn Val Val Asp Leu Val Lys Leu Gln Ser Ala Lys Glu Asn Asn 
        675                 680                 685             


Glu Ala Leu Ser Asp Glu Glu Phe Ala Glu Leu Phe Thr Glu Asp Lys 
    690                 695                 700                 


Pro Val Leu Phe Ala Tyr His Ser Tyr Ala Arg Asp Val Arg Gly Leu 
705                 710                 715                 720 


Ile Tyr Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Glu 
                725                 730                 735     


Glu Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asn 
            740                 745                 750         


Ile Asp Arg Tyr Glu Leu Gln Ala Glu Ala Leu Arg Met Ile Asp Ala 
        755                 760                 765             


Asp Lys Tyr Ala Asp Lys Ile Asn Glu Leu Glu Ala Phe Arg Gln Glu 
    770                 775                 780                 


Ala Phe Gln Phe Ala Val Asp Asn Gly Tyr Asp His Pro Asp Tyr Thr 
785                 790                 795                 800 


Asp Trp Val Tyr Ser Gly Val Asn Thr Asn Lys Gln Gly Ala Ile Ser 
                805                 810                 815     


Ala Thr Ala Ala Thr Ala Gly Asp Asn Glu 
            820                 825     


<210> 2
<211> 842
<212> PRT
<213> Collinsella aerofaciens

<400> 2
Met Ala Lys Thr Leu Gly Thr Pro Trp Gln Lys Leu Gly His Glu Val 
1               5                   10                  15      


Pro Ala Ser Glu Leu Glu Gly Val Asp Leu Tyr Trp Arg Ala Ser Asn 
            20                  25                  30          


Tyr Leu Ser Val Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met Arg 
        35                  40                  45              


Ala Asp Phe Val Asp Asp Lys Thr Gly Glu Ala Arg Asp Phe Gly Arg 
    50                  55                  60                  


Pro Asp Val Lys His Arg Leu Val Gly His Trp Gly Thr Thr Pro Gly 
65                  70                  75                  80  


Ile Asn Phe Leu Phe Gly His Val Asn Arg Leu Ile Ala Asp His Asn 
                85                  90                  95      


Gln Asn Ala Ile Phe Leu Met Gly Pro Gly His Gly Gly Pro Ala Gly 
            100                 105                 110         


Thr Ala Gln Ser Leu Leu Asp Gly Thr Tyr Arg Glu Ile Arg Pro Asp 
        115                 120                 125             


Ile Thr Asn Asp Glu Ala Gly Leu Gln Lys Phe Phe Arg Gln Phe Ser 
    130                 135                 140                 


Tyr Pro Gly Gly Ile Pro Ser His Phe Ala Pro Glu Thr Pro Gly Ser 
145                 150                 155                 160 


Ile His Glu Gly Gly Glu Leu Gly Tyr Thr Leu Ser His Ala Tyr Gly 
                165                 170                 175     


Ala Val Met Asp Asn Pro Ser Leu Leu Ala Val Ala Val Val Gly Asp 
            180                 185                 190         


Gly Glu Ser Glu Thr Gly Pro Leu Ala Thr Ser Trp Gln Ser Asn Lys 
        195                 200                 205             


Leu Val Asn Pro Ala Thr Asp Gly Ile Val Leu Pro Ile Leu His Leu 
    210                 215                 220                 


Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile Leu Ala Arg Val Ser Asp 
225                 230                 235                 240 


Glu Glu Leu Thr Lys Phe Phe Glu Gly Met Gly Tyr Lys Pro His Phe 
                245                 250                 255     


Phe Ile Ala Gly Phe Asp Asp Glu Ser His Ala Ser Ile His Glu Arg 
            260                 265                 270         


Phe Ala Ala Leu Phe Glu Gln Val Phe Asp Glu Ile Cys Asp Ile Lys 
        275                 280                 285             


Ala Thr Ala Gln Ala Gln Ala Ala Ala Gly Glu Thr Val Val Arg Pro 
    290                 295                 300                 


Ala Tyr Pro Met Ile Val Phe Arg Thr Pro Lys Gly Trp Thr Cys Pro 
305                 310                 315                 320 


Lys Gln Ile Asp Gly Lys Lys Thr Glu Asp Ser Trp Arg Ala His Gln 
                325                 330                 335     


Val Pro Leu Ala Ser Ala Lys Asp Thr His Glu His Phe Arg Val Leu 
            340                 345                 350         


Arg Glu Trp Leu Arg Ser Tyr Lys Pro Glu Glu Leu Phe Thr Pro Glu 
        355                 360                 365             


Gly Gln Val Arg Pro Glu Val Thr Ala Phe Met Pro Thr Gly Glu Leu 
    370                 375                 380                 


Arg Ile Gly Ala Asn Pro Asn Ala Asn Gly Gly Lys Val Arg Arg Glu 
385                 390                 395                 400 


Leu Glu Leu Pro Asp Ile His Ala His Glu Ile Pro Val Ala Glu Lys 
                405                 410                 415     


Gly His Gly Trp Gly Ser Thr Glu Ala Ala Arg Val Phe Gly Glu Tyr 
            420                 425                 430         


Thr Ala Asp Val Leu Ala Lys Asn Met Asp Asp Phe Arg Ile Phe Gly 
        435                 440                 445             


Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Arg Val Thr 
    450                 455                 460                 


Lys Lys Gln Trp Asp Ala Gly Phe Tyr Glu Asp Glu Ala Asn Asp Glu 
465                 470                 475                 480 


Leu Leu Ala Gly Ser Gly Lys Val Val Glu Gln Leu Ser Glu His Gln 
                485                 490                 495     


Cys Glu Gly Phe Leu Glu Ala Tyr Val Leu Thr Gly Arg Ser Gly Val 
            500                 505                 510         


Trp Ser Ser Tyr Glu Ser Phe Val His Val Val Asp Ser Met Val Asn 
        515                 520                 525             


Gln His Cys Lys Trp Leu Glu Ala Thr Lys Arg Glu Ile Pro Trp Arg 
    530                 535                 540                 


Ala Pro Ile Ser Gly Leu Asn Ile Leu Leu Ser Ser His Val Trp Arg 
545                 550                 555                 560 


Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Phe Ile Asp Leu 
                565                 570                 575     


Leu Leu Asn Lys Ala Asn Asp Thr His Ile Val Asn Ala Tyr Tyr Pro 
            580                 585                 590         


Ala Asp Ala Asn Met Ala Leu Ala Val Ala Glu Arg Val Tyr Gln Ser 
        595                 600                 605             


Thr Asp Cys Val Asn Ala Ile Phe Cys Gly Lys Gln Pro Ala Pro Thr 
    610                 615                 620                 


Phe Gln Thr Val Asp Glu Ala Lys Ala Glu Leu Ala Glu Gly Val Ala 
625                 630                 635                 640 


Asn Trp Glu Trp Ala Ser Thr Ala Asp Ser Leu Gly Glu Ala Asp Val 
                645                 650                 655     


Val Val Ala Thr Cys Gly Asp Val Pro Thr Leu Glu Ala Leu Ala Ala 
            660                 665                 670         


Thr Asp Met Leu Arg Glu Leu Gly Ile Lys Val Trp Phe Val Asn Val 
        675                 680                 685             


Val Asp Leu Leu Lys Ile Gln Asn Val Cys Glu Asn Asp Gln Ala Ile 
    690                 695                 700                 


Ser Asp Glu Arg Trp Ala Glu Leu Phe Gly Cys Gly Glu Lys Pro Val 
705                 710                 715                 720 


Leu Phe Ala Phe His Ala Tyr Ala Gly Thr Ile Arg Arg Leu Ile Trp 
                725                 730                 735     


Asn Arg Pro Gly His Asp Ala Phe Arg Val His Gly Tyr Glu Glu Lys 
            740                 745                 750         


Gly Ser Thr Thr Thr Pro Phe Asp Met Leu Arg Leu Asn Asn Met Asp 
        755                 760                 765             


Arg Trp Ala Leu Ala Ala Asp Val Leu Arg Met Val Asp Ala Val Lys 
    770                 775                 780                 


Phe Ala Glu Gln Ile Asp Glu Trp Glu Ala Phe Arg Thr Glu Ala Phe 
785                 790                 795                 800 


Glu Phe Ala Cys Asp Glu Gly Phe Asp His Pro Ala Phe Thr Asp Trp 
                805                 810                 815     


Val Trp Pro Asp Ala Ala Ala Ala Thr Ala Ala Asp Gly Ala Leu Ser 
            820                 825                 830         


Ala Thr Gln Leu Thr Ala Gly Asp Asn Glu 
        835                 840         


<210> 3
<211> 2478
<212> DNA
<213> Bifidobacterium adolescentis

<400> 3
atgatgacga gcccagttat tgggacccct tggaaaaagt taaacgcccc ggtaagtgag       60

gaagctatag aaggagtgga taaatactgg agggcggcaa attatttgtc gatcggccaa      120

atttatctcc gatctaaccc gcttatgaaa gagcccttta cacgtgaaga cgtcaaacat      180

cgcctggtgg gtcactgggg cactaccccg ggtctgaatt tcctgatcgg ccatattaat      240

cggctaatcg cggatcacca gcagaacacg gttattatca tggggccggg tcatggcggg      300

ccagcaggta ccgcccaatc atacctggat ggaacgtata ccgaatactt tcccaatata      360

actaaagacg aagcgggctt gcagaagttc tttcgccagt tcagctatcc gggtggcatt      420

ccgtcccact atgcccctga aactccagga tctatccatg agggcggtga actgggatac      480

gcattgtccc acgcttatgg cgcggtaatg aacaacccaa gcctgtttgt gcctgcgatt      540

gtcggtgatg gtgaagccga aaccggcccg ctcgctacag gctggcaaag taacaaactg      600

attaatccgc gtaccgatgg tatcgttctc ccgattctgc atttaaacgg ctataaaatc      660

gcgaacccaa cgattttatc gcgcatctca gacgaggagc tgcatgagtt ttttcatggg      720

atgggctacg aaccctatga atttgtggct gggttcgata atgaggatca cttaagtata      780

caccgtcgtt tcgcagaact tttcgaaacc gtgtttgacg agatttgcga cattaaagcc      840

gccgcgcaga ctgacgatat gacgcgcccg ttttatccga tgatcatctt ccgaaccccg      900

aagggctgga catgtccgaa atttatcgat ggtaaaaaga ctgagggttc ttggcgctcg      960

caccaagttc ctctggcaag cgcccgtgat accgaagcgc atttcgaagt cctgaaaaat     1020

tggcttgaaa gctacaaacc tgaggaattg tttgacgaaa atggcgcagt caaacctgaa     1080

gtgacggcat tcatgccaac tggcgagtta cgaattggtg aaaacccgaa tgccaatggg     1140

ggccgcatta gggaagagct aaaattaccg aagctggaag attacgaggt aaaggaagtc     1200

gcggaatatg gacatggttg ggggcagctg gaggcgaccc gtcgcctggg agtgtacaca     1260

cgtgatatca ttaaaaacaa cccagacagc tttcgcatct ttggcccaga tgaaaccgct     1320

tcaaaccgtt tacaggccgc atatgatgtt accaacaaac aatgggacgc tggctatttg     1380

agtgctcagg tggatgaaca catggcggtg acgggtcagg tgaccgaaca gctgagtgaa     1440

catcaaatgg aaggctttct tgagggttat ctgttgaccg gtcggcacgg tatctggtcc     1500

tcgtatgagt ctttcgtaca cgtcattgat agcatgctca atcagcatgc caagtggctg     1560

gaagctactg ttcgggaaat cccgtggcgc aaaccgattt catctatgaa cctgctggtt     1620

agtagccatg tttggaggca ggaccataat ggattctcgc accaagatcc cggtgtaacg     1680

tccgtacttc tgaacaaatg ctttaacaat gaccatgtaa taggaattta cttccccgtg     1740

gatagcaaca tgctcttggc ggttgcggaa aaatgttaca aatccactaa caaaatcaat     1800

gctatcatcg caggaaagca gccagccgcg acatggctga cgttagatga agctagagcg     1860

gaactggaga aaggcgcagc agaatggaaa tgggcctcca atgttaagtc taacgatgaa     1920

gctcagattg tgcttgcggc caccggtgac gtcccgaccc aagaaattat ggccgcagcc     1980

gataagttag acgccatggg catcaaattt aaagtcgtaa atgtggttga tctggtgaaa     2040

ctccaatctg cgaaggaaaa taacgaggct ttgtcagacg aagagtttgc ggaactgttc     2100

accgaagata aaccggtcct gttcgcctac cattcgtacg cgcgcgatgt tcgtgggctg     2160

atttatgatc gtccaaacca tgacaatttt aatgtccacg ggtatgaaga acagggtagt     2220

acgacaacgc cgtacgatat ggtgcgggta aataatatag atcgttatga gctgcaagca     2280

gaggcgctac gcatgatcga cgcggataaa tacgccgaca aaattaatga attagaagct     2340

tttcgccagg aagctttcca gtttgcagtc gataacggct atgatcatcc agactacact     2400

gactgggtgt atagcggggt gaatactaac aaacagggtg cgattagtgc aaccgccgcc     2460

accgccggcg acaatgaa                                                   2478


<210> 4
<211> 2526
<212> DNA
<213> Collinsella aerofaciens

<400> 4
atggcaaaaa ccttagggac tccgtggcag aagttgggtc acgaagtacc cgcgagcgag       60

cttgaaggcg tcgatctgta ctggcgtgcc tccaactatc tgtcagttgg acaaatatat      120

ctgaggtcta atccactgat gcgcgctgac tttgtggatg ataaaacagg cgaagcccgc      180

gacttcggtc gtccggatgt gaaacatcgg ctcgtcggcc attggggtac gacccctggc      240

atcaactttc tgttcgggca cgtgaatcga ttgattgcgg accataacca gaacgcaatc      300

tttctaatgg gaccgggcca cggtggccca gcgggtacgg cacagtcgct cctggacggg      360

acctaccgcg agattagacc ggatattact aatgatgaag ccggccttca aaaattcttt      420

cgtcagttta gctatccggg tggtatcccg agtcatttcg ctccagagac acctggatcg      480

attcatgaag ggggagaact aggctacacc ttaagccacg cgtatggcgc ggttatggac      540

aatccgtctt tgctggcggt cgccgtagtg ggtgatggtg agagtgaaac gggacctctt      600

gcgacctcct ggcagagcaa caaactggtt aatccggcca cggatggcat tgtgctgccc      660

atccttcatc tgaacggcta caagattgct aacccgacca tcctcgcccg tgtgtccgat      720

gaagaactga ctaaattttt cgagggcatg ggttataaac cccatttctt tattgcaggg      780

ttcgatgacg aatcacacgc ttcgatccac gagcgctttg cggcgctatt cgaacaagtc      840

tttgacgaga tttgcgatat aaaggccacg gcacaggccc aagcggcggc aggggaaaca      900

gtagtacgcc ctgcatatcc gatgattgtt tttcgtacac caaaaggctg gacctgtccg      960

aaacagatcg acgggaaaaa aaccgaagat tcttggcgcg cacaccaggt tccgctggct     1020

tccgccaaag atactcatga gcatttccgc gtgctgcgtg aatggttacg gagctacaaa     1080

cccgaagaat tgtttacccc cgagggtcaa gtgcgtccgg aggtcaccgc tttcatgcct     1140

acgggtgaac tgcgtatagg tgccaatccg aacgcaaatg gcggcaaagt gcgccgagaa     1200

ttagaactcc cggatataca cgcgcatgaa atcccagttg cggaaaaggg ccatgggtgg     1260

ggctcgaccg aggctgctcg ggtgtttgga gaatataccg ctgatgtact ggccaagaac     1320

atggacgatt ttcgcatttt tggtccagat gaaacagcca gtaaccgact gcaagcggct     1380

tatagggtca cgaaaaaaca gtgggatgcg ggtttctacg aagatgaggc aaatgacgag     1440

ttgttagccg ggagcgggaa ggtggtggag cagttatcag aacatcaatg cgaaggcttt     1500

ttagaagcat acgtcctgac gggtcgcagt ggtgtttgga gcagttacga aagcttcgtc     1560

cacgtcgtgg actccatggt taaccagcac tgtaagtggc tggaagcgac caaacgagaa     1620

attccgtgga gagcccctat cagcggcttg aatattcttc tgtcgagtca cgtctggcgc     1680

caggaccata acggattttc gcaccaagat ccaggcttta tcgatctttt attaaataag     1740

gcaaatgata cccatatcgt aaacgcctat tacccggcgg acgcgaacat ggctctggcc     1800

gtggcggagc gtgtctatca gtctacggac tgcgttaatg cgattttttg cggaaaacag     1860

cccgcaccga ctttccaaac ggtggatgaa gccaaagccg aactggccga gggcgtagcg     1920

aactgggaat gggcatcaac tgcggactca ctgggggaag cagacgtcgt ggttgcgacc     1980

tgtggggatg tacctaccct ggaagccctc gcggctactg acatgctacg tgaactgggc     2040

atcaaagtct ggttcgtaaa tgttgttgac ctgttgaaaa tccagaatgt ctgtgaaaat     2100

gatcaagcga tttcagatga gcggtgggcc gagctgtttg ggtgcggcga aaaaccggtg     2160

cttttcgcgt ttcatgcgta tgcgggtaca attcgtcggc tgatctggaa ccgtccggga     2220

catgatgcgt ttagagtaca cggttatgag gaaaaaggtt ctaccacaac cccgtttgat     2280

atgctacgct tgaacaacat ggatcgctgg gccctcgcag ccgatgtgct gcgcatggtt     2340

gatgctgtta aattcgcgga gcaaattgac gaatgggaag cattcagaac ggaagcattc     2400

gaatttgcct gcgatgaagg ctttgatcac ccggccttca ctgattgggt gtggcccgac     2460

gccgccgcgg caaccgctgc cgacggtgcg ctgagcgcga cacagctcac ggctggcgat     2520

aatgaa                                                                2526


<210> 5
<211> 846
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(6)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (19)..(22)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (33)..(33)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (50)..(52)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (54)..(65)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (67)..(67)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (87)..(87)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (98)..(98)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (101)..(103)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (119)..(119)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (125)..(125)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (127)..(128)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (133)..(133)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (155)..(155)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (187)..(189)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (191)..(191)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (205)..(205)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (212)..(212)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (215)..(215)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (238)..(238)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (240)..(240)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (246)..(247)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (257)..(258)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (267)..(267)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (269)..(269)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (273)..(273)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (277)..(277)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (281)..(281)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (292)..(292)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (295)..(304)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (307)..(307)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (312)..(312)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (324)..(324)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (332)..(332)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (345)..(345)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (348)..(349)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (352)..(352)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (355)..(356)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (359)..(359)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (368)..(370)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (390)..(390)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (398)..(399)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (401)..(401)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (404)..(404)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (408)..(408)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (409)..(411)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (413)..(415)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (419)..(419)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (425)..(426)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (429)..(429)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (431)..(432)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (434)..(434)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (437)..(437)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (439)..(439)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (440)..(440)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (441)..(442)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (444)..(444)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (446)..(446)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (465)..(465)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (468)..(468)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (475)..(478)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (480)..(481)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (484)..(485)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (487)..(488)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (490)..(490)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (492)..(492)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (500)..(500)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (506)..(506)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (508)..(508)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (515)..(515)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (526)..(526)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (530)..(530)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (534)..(534)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (541)..(541)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (548)..(548)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (552)..(553)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (555)..(555)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (557)..(557)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (576)..(579)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (584)..(585)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (588)..(588)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (590)..(593)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (595)..(595)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (597)..(597)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (599)..(599)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (602)..(602)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (608)..(609)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (611)..(611)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (615)..(616)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (620)..(621)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (627)..(627)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (629)..(630)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (632)..(632)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (636)..(636)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (640)..(641)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (643)..(643)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (645)..(645)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (647)..(647)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (651)..(653)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (655)..(656)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (659)..(660)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (662)..(662)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (664)..(665)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (671)..(671)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (673)..(674)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (677)..(677)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (679)..(679)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (681)..(683)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (687)..(689)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (696)..(696)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (698)..(698)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (700)..(702)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (708)..(708)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (712)..(713)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (718)..(721)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (728)..(728)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (730)..(730)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (733)..(735)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (737)..(737)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (740)..(740)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (744)..(744)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (747)..(747)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (749)..(749)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (756)..(756)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (763)..(763)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (766)..(766)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (768)..(768)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (771)..(771)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (774)..(775)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (777)..(777)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (779)..(780)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (784)..(784)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (787)..(787)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (789)..(789)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (791)..(792)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (796)..(796)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (801)..(801)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (808)..(808)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (810)..(810)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (812)..(812)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (816)..(817)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (822)..(828)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (830)..(832)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (835)..(835)
<223> Leucine or Isoleucine

<220>
<221> MOD_RES
<222> (839)..(840)
<223> Any amino acid

<400> 5
Met Met Xaa Xaa Xaa Xaa Xaa Gly Thr Pro Trp Xaa Lys Leu Xaa Xaa 
1               5                   10                  15      


Xaa Val Xaa Xaa Xaa Xaa Xaa Glu Gly Val Asp Xaa Tyr Trp Arg Ala 
            20                  25                  30          


Xaa Asn Tyr Leu Ser Xaa Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu 
        35                  40                  45              


Met Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Arg Xaa Asp Val Lys His Arg Leu Val Gly His Trp Gly Thr Thr 
65                  70                  75                  80  


Pro Gly Xaa Asn Phe Leu Xaa Gly His Xaa Asn Arg Leu Ile Ala Asp 
                85                  90                  95      


His Xaa Gln Asn Xaa Xaa Xaa Xaa Met Gly Pro Gly His Gly Gly Pro 
            100                 105                 110         


Ala Gly Thr Ala Gln Ser Xaa Leu Asp Gly Thr Tyr Xaa Glu Xaa Xaa 
        115                 120                 125             


Pro Asx Ile Thr Xaa Asp Glu Ala Gly Leu Gln Lys Phe Phe Arg Gln 
    130                 135                 140                 


Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Xaa Ala Pro Glu Thr Pro 
145                 150                 155                 160 


Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Xaa Leu Ser His Ala 
                165                 170                 175     


Tyr Gly Ala Val Met Asx Asn Pro Ser Leu Xaa Xaa Xaa Ala Xaa Val 
            180                 185                 190         


Gly Asp Gly Glu Xaa Glu Thr Gly Pro Leu Ala Thr Xaa Trp Gln Ser 
        195                 200                 205             


Asn Lys Leu Xaa Asn Pro Xaa Thr Asp Gly Ile Val Leu Pro Ile Leu 
    210                 215                 220                 


His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile Leu Xaa Arg Xaa 
225                 230                 235                 240 


Ser Asp Glu Glu Leu Xaa Xaa Phe Phe Xaa Gly Met Gly Tyr Xaa Pro 
                245                 250                 255     


Xaa Xaa Phe Xaa Ala Gly Phe Asp Asx Glu Xaa His Xaa Ser Ile His 
            260                 265                 270         


Xaa Arg Phe Ala Xaa Leu Phe Glu Xaa Val Phe Asp Glu Ile Cys Asp 
        275                 280                 285             


Ile Lys Ala Xaa Ala Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Arg Pro Xaa Tyr Pro Met Ile Xaa Phe Arg Thr Pro Lys Gly Trp Thr 
305                 310                 315                 320 


Cys Pro Lys Xaa Ile Asp Gly Lys Lys Thr Glu Xaa Ser Trp Arg Xaa 
                325                 330                 335     


His Gln Val Pro Leu Ala Ser Ala Xaa Asp Thr Xaa Xaa His Phe Xaa 
            340                 345                 350         


Val Leu Xaa Xaa Trp Leu Xaa Ser Tyr Lys Pro Glu Glu Leu Phe Xaa 
        355                 360                 365             


Xaa Xaa Gly Xaa Val Xaa Pro Glu Val Thr Ala Phe Met Pro Thr Gly 
    370                 375                 380                 


Glu Leu Arg Ile Gly Xaa Asn Pro Asn Ala Asn Gly Gly Xaa Xaa Arg 
385                 390                 395                 400 


Xaa Glu Leu Xaa Leu Pro Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Val 
                405                 410                 415     


Ala Glu Xaa Gly His Gly Trp Gly Xaa Xaa Glu Ala Xaa Arg Xaa Xaa 
            420                 425                 430         


Gly Xaa Tyr Thr Xaa Asp Xaa Xaa Xaa Xaa Asn Xaa Asp Xaa Phe Arg 
        435                 440                 445             


Ile Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr 
    450                 455                 460                 


Xaa Val Thr Xaa Lys Gln Trp Asp Ala Gly Xaa Xaa Xaa Xaa Glx Xaa 
465                 470                 475                 480 


Xaa Asp Glu Xaa Xaa Ala Xaa Xaa Gly Xaa Val Xaa Glu Gln Leu Ser 
                485                 490                 495     


Glu His Gln Xaa Glu Gly Phe Leu Glu Xaa Tyr Xaa Leu Thr Gly Arg 
            500                 505                 510         


Xaa Gly Xaa Trp Ser Ser Tyr Glu Ser Phe Val His Val Xaa Asp Ser 
        515                 520                 525             


Met Xaa Asn Gln His Xaa Lys Trp Leu Glu Ala Thr Xaa Arg Glu Ile 
    530                 535                 540                 


Pro Trp Arg Xaa Pro Ile Ser Xaa Xaa Asn Xaa Leu Xaa Ser Ser His 
545                 550                 555                 560 


Val Trp Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Xaa 
                565                 570                 575     


Xaa Xaa Xaa Leu Leu Asn Lys Xaa Xaa Asn Asx Xaa His Xaa Xaa Xaa 
            580                 585                 590         


Xaa Tyr Xaa Pro Xaa Asp Xaa Asn Met Xaa Leu Ala Val Ala Glu Xaa 
        595                 600                 605             


Xaa Tyr Xaa Ser Thr Asx Xaa Xaa Asn Ala Ile Xaa Xaa Gly Lys Gln 
    610                 615                 620                 


Pro Ala Xaa Thr Xaa Xaa Thr Xaa Asp Glu Ala Xaa Ala Glu Leu Xaa 
625                 630                 635                 640 


Xaa Gly Xaa Ala Xaa Trp Xaa Trp Ala Ser Xaa Xaa Xaa Ser Xaa Xaa 
                645                 650                 655     


Glu Ala Xaa Xaa Val Xaa Ala Xaa Xaa Gly Asp Val Pro Thr Xaa Glu 
            660                 665                 670         


Xaa Xaa Ala Ala Xaa Asp Xaa Leu Xaa Xaa Xaa Gly Ile Lys Xaa Xaa 
        675                 680                 685             


Xaa Val Asn Val Val Asp Leu Xaa Lys Xaa Gln Xaa Xaa Xaa Glu Asn 
    690                 695                 700                 


Asx Glx Ala Xaa Ser Asp Glu Xaa Xaa Ala Glu Leu Phe Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Lys Pro Val Leu Phe Ala Xaa His Xaa Tyr Ala Xaa Xaa Xaa Arg 
                725                 730                 735     


Xaa Leu Ile Xaa Asx Arg Pro Xaa His Asp Xaa Phe Xaa Val His Gly 
            740                 745                 750         


Tyr Glu Glu Xaa Gly Ser Thr Thr Thr Pro Xaa Asp Met Xaa Arg Xaa 
        755                 760                 765             


Asn Asn Xaa Asp Arg Xaa Xaa Leu Xaa Ala Xaa Xaa Leu Arg Met Xaa 
    770                 775                 780                 


Asp Ala Xaa Lys Xaa Ala Xaa Xaa Ile Asx Glu Xaa Glu Ala Phe Arg 
785                 790                 795                 800 


Xaa Glu Ala Phe Glx Phe Ala Xaa Asp Xaa Gly Xaa Asp His Pro Xaa 
                805                 810                 815     


Xaa Thr Asp Trp Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Xaa Xaa 
            820                 825                 830         


Gly Ala Xaa Ser Ala Thr Xaa Xaa Thr Ala Gly Asp Asn Glu 
        835                 840                 845     


