                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
       BETH ISRAEL DEACONESS MEDICAL CENTER
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

<130>  DFS-31525

<140>  PCT/US2022/023849
<141>  2022-04-07

<150>  US 63/171,808
<151>  2021-04-07

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  6881
<212>  DNA
<213>  Homo sapiens

<400>  1
acccctcgcc gcaccacaca cagcgcgggc ttctagcgct cggcaccggc gggccaggcg       60

cgtcctgcct tcatttatcc agcagctttt cggaaaatgc atttgctgtt cggagtttaa      120

tcagaagagg attcctgcct ccgtccccgg ctccttcatc gtcccctctc ccctgtctct      180

ctcctgggga ggcgtgaagc ggtcccgtgg atagagattc atgcctgtgc ccgcgcgtgt      240

gtgcgcgcgt gtaaattgcc gagaagggga aaacatcaca ggacttctgc gaataccgga      300

ctgaaaattg taattcatct gccgccgccg ctgccttttt tttttctcga gctcttgaga      360

tctccggttg ggattcctgc ggattgacat ttctgtgaag cagaagtctg ggaatcgatc      420

tggaaatcct cctaattttt actccctctc cccgcgactc ctgattcatt gggaagtttc      480

aaatcagcta taactggaga gtgctgaaga ttgatgggat cgttgcctta tgcatttgtt      540

ttggttttac aaaaaggaaa cttgacagag gatcatgctg tacttaaaaa atacaacatc      600

acagaggaag tagactgata ttaacaatac ttactaataa taacgtgcct catgaaataa      660

agatccgaaa ggaattggaa taaaaatttc ctgcatctca tgccaagggg gaaacaccag      720

aatcaagtgt tccgcgtgat tgaagacacc ccctcgtcca agaatgcaaa gcacatccaa      780

taaaatagct ggattataac tcctcttctt tctctggggg ccgtggggtg ggagctgggg      840

cgagaggtgc cgttggcccc cgttgctttt cctctgggaa ggatggcgca cgctgggaga      900

acagggtacg ataaccggga gatagtgatg aagtacatcc attataagct gtcgcagagg      960

ggctacgagt gggatgcggg agatgtgggc gccgcgcccc cgggggccgc ccccgcaccg     1020

ggcatcttct cctcccagcc cgggcacacg ccccatccag ccgcatcccg ggacccggtc     1080

gccaggacct cgccgctgca gaccccggct gcccccggcg ccgccgcggg gcctgcgctc     1140

agcccggtgc cacctgtggt ccacctgacc ctccgccagg ccggcgacga cttctcccgc     1200

cgctaccgcc gcgacttcgc cgagatgtcc agccagctgc acctgacgcc cttcaccgcg     1260

cggggacgct ttgccacggt ggtggaggag ctcttcaggg acggggtgaa ctgggggagg     1320

attgtggcct tctttgagtt cggtggggtc atgtgtgtgg agagcgtcaa ccgggagatg     1380

tcgcccctgg tggacaacat cgccctgtgg atgactgagt acctgaaccg gcacctgcac     1440

acctggatcc aggataacgg aggctgggat gcctttgtgg aactgtacgg ccccagcatg     1500

cggcctctgt ttgatttctc ctggctgtct ctgaagactc tgctcagttt ggccctggtg     1560

ggagcttgca tcaccctggg tgcctatctg ggccacaagt gaagtcaaca tgcctgcccc     1620

aaacaaatat gcaaaaggtt cactaaagca gtagaaataa tatgcattgt cagtgatgta     1680

ccatgaaaca aagctgcagg ctgtttaaga aaaaataaca cacatataaa catcacacac     1740

acagacagac acacacacac acaacaatta acagtcttca ggcaaaacgt cgaatcagct     1800

atttactgcc aaagggaaat atcatttatt ttttacatta ttaagaaaaa aagatttatt     1860

tatttaagac agtcccatca aaactcctgt ctttggaaat ccgaccacta attgccaagc     1920

accgcttcgt gtggctccac ctggatgttc tgtgcctgta aacatagatt cgctttccat     1980

gttgttggcc ggatcaccat ctgaagagca gacggatgga aaaaggacct gatcattggg     2040

gaagctggct ttctggctgc tggaggctgg ggagaaggtg ttcattcact tgcatttctt     2100

tgccctgggg gctgtgatat taacagaggg agggttcctg tggggggaag tccatgcctc     2160

cctggcctga agaagagact ctttgcatat gactcacatg atgcatacct ggtgggagga     2220

aaagagttgg gaacttcaga tggacctagt acccactgag atttccacgc cgaaggacag     2280

cgatgggaaa aatgccctta aatcatagga aagtattttt ttaagctacc aattgtgccg     2340

agaaaagcat tttagcaatt tatacaatat catccagtac cttaagccct gattgtgtat     2400

attcatatat tttggatacg caccccccaa ctcccaatac tggctctgtc tgagtaagaa     2460

acagaatcct ctggaacttg aggaagtgaa catttcggtg acttccgcat caggaaggct     2520

agagttaccc agagcatcag gccgccacaa gtgcctgctt ttaggagacc gaagtccgca     2580

gaacctgcct gtgtcccagc ttggaggcct ggtcctggaa ctgagccggg gccctcactg     2640

gcctcctcca gggatgatca acagggcagt gtggtctccg aatgtctgga agctgatgga     2700

gctcagaatt ccactgtcaa gaaagagcag tagaggggtg tggctgggcc tgtcaccctg     2760

gggccctcca ggtaggcccg ttttcacgtg gagcatggga gccacgaccc ttcttaagac     2820

atgtatcact gtagagggaa ggaacagagg ccctgggccc ttcctatcag aaggacatgg     2880

tgaaggctgg gaacgtgagg agaggcaatg gccacggccc attttggctg tagcacatgg     2940

cacgttggct gtgtggcctt ggcccacctg tgagtttaaa gcaaggcttt aaatgacttt     3000

ggagagggtc acaaatccta aaagaagcat tgaagtgagg tgtcatggat taattgaccc     3060

ctgtctatgg aattacatgt aaaacattat cttgtcactg tagtttggtt ttatttgaaa     3120

acctgacaaa aaaaaagttc caggtgtgga atatgggggt tatctgtaca tcctggggca     3180

ttaaaaaaaa aatcaatggt ggggaactat aaagaagtaa caaaagaagt gacatcttca     3240

gcaaataaac taggaaattt ttttttcttc cagtttagaa tcagccttga aacattgatg     3300

gaataactct gtggcattat tgcattatat accatttatc tgtattaact ttggaatgta     3360

ctctgttcaa tgtttaatgc tgtggttgat atttcgaaag ctgctttaaa aaaatacatg     3420

catctcagcg tttttttgtt tttaattgta tttagttatg gcctatacac tatttgtgag     3480

caaaggtgat cgttttctgt ttgagatttt tatctcttga ttcttcaaaa gcattctgag     3540

aaggtgagat aagccctgag tctcagctac ctaagaaaaa cctggatgtc actggccact     3600

gaggagcttt gtttcaacca agtcatgtgc atttccacgt caacagaatt gtttattgtg     3660

acagttatat ctgttgtccc tttgaccttg tttcttgaag gtttcctcgt ccctgggcaa     3720

ttccgcattt aattcatggt attcaggatt acatgcatgt ttggttaaac ccatgagatt     3780

cattcagtta aaaatccaga tggcaaatga ccagcagatt caaatctatg gtggtttgac     3840

ctttagagag ttgctttacg tggcctgttt caacacagac ccacccagag ccctcctgcc     3900

ctccttccgc gggggctttc tcatggctgt ccttcagggt cttcctgaaa tgcagtggtg     3960

cttacgctcc accaagaaag caggaaacct gtggtatgaa gccagacctc cccggcgggc     4020

ctcagggaac agaatgatca gacctttgaa tgattctaat ttttaagcaa aatattattt     4080

tatgaaaggt ttacattgtc aaagtgatga atatggaata tccaatcctg tgctgctatc     4140

ctgccaaaat cattttaatg gagtcagttt gcagtatgct ccacgtggta agatcctcca     4200

agctgcttta gaagtaacaa tgaagaacgt ggacgttttt aatataaagc ctgttttgtc     4260

ttttgttgtt gttcaaacgg gattcacaga gtatttgaaa aatgtatata tattaagagg     4320

tcacgggggc taattgctgg ctggctgcct tttgctgtgg ggttttgtta cctggtttta     4380

ataacagtaa atgtgcccag cctcttggcc ccagaactgt acagtattgt ggctgcactt     4440

gctctaagag tagttgatgt tgcattttcc ttattgttaa aaacatgtta gaagcaatga     4500

atgtatataa aagcctcaac tagtcatttt tttctcctct tctttttttt cattatatct     4560

aattattttg cagttgggca acagagaacc atccctattt tgtattgaag agggattcac     4620

atctgcatct taactgctct ttatgaatga aaaaacagtc ctctgtatgt actcctcttt     4680

acactggcca gggtcagagt taaatagagt atatgcactt tccaaattgg ggacaagggc     4740

tctaaaaaaa gccccaaaag gagaagaaca tctgagaacc tcctcggccc tcccagtccc     4800

tcgctgcaca aatactccgc aagagaggcc agaatgacag ctgacagggt ctatggccat     4860

cgggtcgtct ccgaagattt ggcaggggca gaaaactctg gcaggcttaa gatttggaat     4920

aaagtcacag aattaaggaa gcacctcaat ttagttcaaa caagacgcca acattctctc     4980

cacagctcac ttacctctct gtgttcagat gtggccttcc atttatatgt gatctttgtt     5040

ttattagtaa atgcttatca tctaaagatg tagctctggc ccagtgggaa aaattaggaa     5100

gtgattataa atcgagagga gttataataa tcaagattaa atgtaaataa tcagggcaat     5160

cccaacacat gtctagcttt cacctccagg atctattgag tgaacagaat tgcaaatagt     5220

ctctatttgt aattgaactt atcctaaaac aaatagttta taaatgtgaa cttaaactct     5280

aattaattcc aactgtactt ttaaggcagt ggctgttttt agactttctt atcacttata     5340

gttagtaatg tacacctact ctatcagaga aaaacaggaa aggctcgaaa tacaagccat     5400

tctaaggaaa ttagggagtc agttgaaatt ctattctgat cttattctgt ggtgtctttt     5460

gcagcccaga caaatgtggt tacacacttt ttaagaaata caattctaca ttgtcaagct     5520

tatgaaggtt ccaatcagat ctttattgtt attcaatttg gatctttcag ggattttttt     5580

tttaaattat tatgggacaa aggacatttg ttggaggggt gggagggagg aagaattttt     5640

aaatgtaaaa cattcccaag tttggatcag ggagttggaa gttttcagaa taaccagaac     5700

taagggtatg aaggacctgt attggggtcg atgtgatgcc tctgcgaaga accttgtgtg     5760

acaaatgaga aacattttga agtttgtggt acgaccttta gattccagag acatcagcat     5820

ggctcaaagt gcagctccgt ttggcagtgc aatggtataa atttcaagct ggatatgtct     5880

aatgggtatt taaacaataa atgtgcagtt ttaactaaca ggatatttaa tgacaacctt     5940

ctggttggta gggacatctg tttctaaatg tttattatgt acaatacaga aaaaaatttt     6000

ataaaattaa gcaatgtgaa actgaattgg agagtgataa tacaagtcct ttagtcttac     6060

ccagtgaatc attctgttcc atgtctttgg acaaccatga ccttggacaa tcatgaaata     6120

tgcatctcac tggatgcaaa gaaaatcaga tggagcatga atggtactgt accggttcat     6180

ctggactgcc ccagaaaaat aacttcaagc aaacatccta tcaacaacaa ggttgttctg     6240

cataccaagc tgagcacaga agatgggaac actggtggag gatggaaagg ctcgctcaat     6300

caagaaaatt ctgagactat taataaataa gactgtagtg tagatactga gtaaatccat     6360

gcacctaaac cttttggaaa atctgccgtg ggccctccag atagctcatt tcattaagtt     6420

tttccctcca aggtagaatt tgcaagagtg acagtggatt gcatttcttt tggggaagct     6480

ttcttttggt ggttttgttt attatacctt cttaagtttt caaccaaggt ttgcttttgt     6540

tttgagttac tggggttatt tttgttttaa ataaaaataa gtgtacaata agtgtttttg     6600

tattgaaagc ttttgttatc aagattttca tacttttacc ttccatggct ctttttaaga     6660

ttgatacttt taagaggtgg ctgatattct gcaacactgt acacataaaa aatacggtaa     6720

ggatacttta catggttaag gtaaagtaag tctccagttg gccaccatta gctataatgg     6780

cactttgttt gtgttgttgg aaaaagtcac attgccatta aactttcctt gtctgtctag     6840

ttaatattgt gaagaaaaat aaagtacagt gtgagatact g                         6881


<210>  2
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  3
<211>  1595
<212>  DNA
<213>  Homo sapiens

<400>  3
acccctcgcc gcaccacaca cagcgcgggc ttctagcgct cggcaccggc gggccaggcg       60

cgtcctgcct tcatttatcc agcagctttt cggaaaatgc atttgctgtt cggagtttaa      120

tcagaagagg attcctgcct ccgtccccgg ctccttcatc gtcccctctc ccctgtctct      180

ctcctgggga ggcgtgaagc ggtcccgtgg atagagattc atgcctgtgc ccgcgcgtgt      240

gtgcgcgcgt gtaaattgcc gagaagggga aaacatcaca ggacttctgc gaataccgga      300

ctgaaaattg taattcatct gccgccgccg ctgccttttt tttttctcga gctcttgaga      360

tctccggttg ggattcctgc ggattgacat ttctgtgaag cagaagtctg ggaatcgatc      420

tggaaatcct cctaattttt actccctctc cccgcgactc ctgattcatt gggaagtttc      480

aaatcagcta taactggaga gtgctgaaga ttgatgggat cgttgcctta tgcatttgtt      540

ttggttttac aaaaaggaaa cttgacagag gatcatgctg tacttaaaaa atacaacatc      600

acagaggaag tagactgata ttaacaatac ttactaataa taacgtgcct catgaaataa      660

agatccgaaa ggaattggaa taaaaatttc ctgcatctca tgccaagggg gaaacaccag      720

aatcaagtgt tccgcgtgat tgaagacacc ccctcgtcca agaatgcaaa gcacatccaa      780

taaaatagct ggattataac tcctcttctt tctctggggg ccgtggggtg ggagctgggg      840

cgagaggtgc cgttggcccc cgttgctttt cctctgggaa ggatggcgca cgctgggaga      900

acagggtacg ataaccggga gatagtgatg aagtacatcc attataagct gtcgcagagg      960

ggctacgagt gggatgcggg agatgtgggc gccgcgcccc cgggggccgc ccccgcaccg     1020

ggcatcttct cctcccagcc cgggcacacg ccccatccag ccgcatcccg ggacccggtc     1080

gccaggacct cgccgctgca gaccccggct gcccccggcg ccgccgcggg gcctgcgctc     1140

agcccggtgc cacctgtggt ccacctgacc ctccgccagg ccggcgacga cttctcccgc     1200

cgctaccgcc gcgacttcgc cgagatgtcc agccagctgc acctgacgcc cttcaccgcg     1260

cggggacgct ttgccacggt ggtggaggag ctcttcaggg acggggtgaa ctgggggagg     1320

attgtggcct tctttgagtt cggtggggtc atgtgtgtgg agagcgtcaa ccgggagatg     1380

tcgcccctgg tggacaacat cgccctgtgg atgactgagt acctgaaccg gcacctgcac     1440

acctggatcc aggataacgg aggctgggta ggtgcacttg gtgatgtgag tctgggctga     1500

ggccacaggt ccgagatgcg ggggttggag tgcgggtggg ctcctggggc aatgggaggc     1560

tgtggagccg gcgaaataaa atcagagttg ttgct                                1595


<210>  4
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic GO-203 peptide

<400>  5

Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys Gln Cys Arg Arg Lys Asn 
1               5                   10                  15      


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  6

Cys Leu Ile Cys 
1               


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is a cysteine, penicillamine, homocysteine, or 
       3-mercaptoproline

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is a cysteine, penicillamine, homocysteine, or 
       3-mercaptoproline

<400>  7

Xaa Leu Ile Xaa Gly Val Leu Val Thr Thr Arg Arg Arg Lys Lys 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  8

Cys Leu Ile Cys Gly Val Leu Val Thr Thr Arg Arg Arg Lys Lys 
1               5                   10                  15