                         Sequence Listing

<110>  Crown Bioscience Inc.
 
<120>  NOVEL ANTI-CD4 ANTIBODIES

<130>  056211-8004WO02

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  mus musculus 

<400>  1

Ser Gly Tyr Trp Asn 
1               5   


<210>  2
<211>  16
<212>  PRT
<213>  mus musculus 

<400>  2

Tyr Ile Ser Phe Ala Asp Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  10
<212>  PRT
<213>  mus musculus 

<400>  3

Asp Asp Tyr Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  4

Arg Ala Ser Gln Asp Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  mus musculus 

<400>  5

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  mus musculus 

<400>  6

Gln Gln Gly Asn Thr Leu Pro Thr 
1               5               


<210>  7
<211>  118
<212>  PRT
<213>  mus musculus 

<400>  7

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly His Lys Leu Glu Phe Leu 
        35                  40                  45              


Gly Tyr Ile Ser Phe Ala Asp Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Asp Leu 
65                  70                  75                  80  


Gln Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr His Cys Ala 
                85                  90                  95      


Arg Asp Asp Tyr Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  8
<211>  106
<212>  PRT
<213>  mus musculus 

<400>  8

Asp Ile His Leu Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ile Cys Arg Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Leu Lys Pro Asp Gly Thr Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Arg 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  9
<211>  354
<212>  DNA
<213>  Artificial 

<220>
<223>  Synthetic

<400>  9
gaagtgcagc ttcaggagtc aggacctagc ctcgtgaaac cttctcagac tctgtccctc       60

acctgttctg tcactggcga ctccatcacc agcggttact ggaattggat ccggaagttc      120

ccaggacata aacttgagtt tttggggtac ataagtttcg ctgataccac taactacaat      180

ccatctctca aaagtcgagt ctccatcact cgagacacat ccaagaacca gttcgacctg      240

cagttgaagt ctgtgactac tgaggacaca gccacatatc actgtgcaag agatgattat      300

ggttattatg caatggacta ctggggtcaa ggaatatcag tcaccgtctc ctca            354


<210>  10
<211>  318
<212>  DNA
<213>  Artificial 

<220>
<223>  Synthetic

<400>  10
gatatccact tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcatttgta gggcaagtca ggacattgac aattatttga actggtatca gctgaagcca      120

gatggaactc ttaaactcct gatctactac acatcaagac tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagaa tattctctca ccattagcaa cctggaacgt      240

gaagatgttg ccacttactt ttgccaacag ggtaatacac ttcccacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  11
<211>  5
<212>  PRT
<213>  mus musculus 

<400>  11

Thr His Trp Met His 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  mus musculus 

<400>  12

Tyr Ile Asn Pro Tyr Thr Gly Ser Gly Glu Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  8
<212>  PRT
<213>  mus musculus 

<400>  13

Asp Ser Thr Gly Ala Met Asp Tyr 
1               5               


<210>  14
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  14

Lys Ala Ser Gln Asp Ile Asn Arg Tyr Leu Ser 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  mus musculus 

<400>  15

Arg Ala Asp Arg Ser Val Asp 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  mus musculus 

<400>  16

Tyr Asp Glu Phe Pro Tyr Thr 
1               5           


<210>  17
<211>  117
<212>  PRT
<213>  mus musculus 

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Ala Asp Ser Leu Asn Thr His 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Thr Gly Ser Gly Glu Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Asp Ser Thr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  107
<212>  PRT
<213>  mus musculus 

<400>  18

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Pro Ile 
        35                  40                  45              


Tyr Arg Ala Asp Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Gln Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  351
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
caggtccagc ttcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagatg       60

tcctgcaaga cttctgccga cagccttaat acccactgga tgcactgggt aaaacagagg      120

cctggacagg gtctggaatg gattggatac attaatcctt acactggttc tggtgaatac      180

agtcagaagt tcaagggcaa ggccacattg actgcagaca tatcctccag cacagcctac      240

atgcaactga tcagcctgac atctgaggac tcagcagtct attactgtgc ctatgattcg      300

acaggtgcca tggactactg gggtcaggga acctcagtca ccgtctcctc a               351


<210>  20
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagaatcact       60

atcacttgca aggcgagtca ggacattaat aggtatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagacccc gatctatcgt gcagacagat cggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaggatatgg gaatttatta ttgtcaacag tatgatgagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  21
<211>  6
<212>  PRT
<213>  mus musculus 

<400>  21

Ser Asp Tyr Ala Trp Asn 
1               5       


<210>  22
<211>  16
<212>  PRT
<213>  mus musculus 

<400>  22

Tyr Ile Ser Tyr Ser Gly Ile Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  23
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  23

Leu Asp Ser Ser Gly Tyr Gly Ala Met Asp Tyr 
1               5                   10      


<210>  24
<211>  15
<212>  PRT
<213>  mus musculus 

<400>  24

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  25
<211>  7
<212>  PRT
<213>  mus musculus 

<400>  25

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  mus musculus 

<400>  26

Gln His Ser Trp Asp Phe Pro Leu Thr 
1               5                   


<210>  27
<211>  120
<212>  PRT
<213>  mus musculus 

<400>  27

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Ser Ser Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  111
<212>  PRT
<213>  mus musculus 

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Arg Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Asp Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  29
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  29
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacataagct acagtggtat cactagctac      180

aacccatctc tcaaaagtcg attctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aaggctagac      300

agctcgggct acggtgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  30
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  30
gacattgtgc tgacacagtc tcctgcttcc ttacctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaggt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga ctttccgctc      300

acgttcggtg ctgggaccaa gctggagctg aaa                                   333


<210>  31
<211>  5
<212>  PRT
<213>  mus musculus 

<400>  31

Ser Ser Tyr Trp Asn 
1               5   


<210>  32
<400>  32
000
<210>  33
<211>  10
<212>  PRT
<213>  mus musculus 

<400>  33

Asp Asp Phe Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  34
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  34

Arg Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  35
<400>  35
000
<210>  36
<400>  36
000
<210>  37
<211>  118
<212>  PRT
<213>  mus musculus 

<400>  37

Glu Val Gln Leu Glu Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Ser 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly His Lys Leu Glu Phe Leu 
        35                  40                  45              


Gly Tyr Ile Ser Phe Ala Asp Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Asp Leu 
65                  70                  75                  80  


Gln Leu Lys Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asp Phe Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  38
<211>  106
<212>  PRT
<213>  mus musculus 

<400>  38

Asp Ile Tyr Val Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ile Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Leu Lys Pro Asp Gly Thr Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  39
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  39
gaagtacagc tggaggagtc tggacctagc ctcgtgaaac cttctcagac tctgtccctc       60

acctgttctg tcactggcga ctccatcacc agcagttact ggaattggat ccggaagttc      120

ccaggacata aacttgagtt tttggggtac ataagtttcg ctgataccac taactacaat      180

ccatctctca aaagtcgaat ctccatcact cgagacacat ccaagaacca gttcgacctg      240

cagttgaagt ctgtgactac tgaggacaca gccacatatt actgtgcaag agatgatttt      300

ggttactatg caatggacta ctggggtcaa gggatatcag tcactgtctc ctca            354


<210>  40
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  40
gatatttacg tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcatttgta gggcaagtca ggacattaac aattatttga actggtatca gttgaagcca      120

gatggaactc ttaaactcct gatctactac acatcaagac tacactcagg agtcccatca      180

aggttcggtg gcagtgggtc tggaacagaa tattctctca ccattagcaa cctggaacaa      240

gaagatgttg ccacttactt ttgccaacag ggtaatacac ttcccacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  41
<211>  5
<212>  PRT
<213>  mus musculus 

<400>  41

Ser Tyr Trp Ile Glu 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  mus musculus 

<400>  42

Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Glu Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  43

Ser Val Ser Ala Ser Asn Trp Tyr Phe Asp Val 
1               5                   10      


<210>  44
<400>  44
000
<210>  45
<400>  45
000
<210>  46
<211>  9
<212>  PRT
<213>  mus musculus 

<400>  46

Gln His Ser Trp Glu Ile Pro Pro Thr 
1               5                   


<210>  47
<211>  120
<212>  PRT
<213>  mus musculus 

<400>  47

Glu Val Lys Leu Gln Gln Ser Gly Thr Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Thr Gly Arg Ala Thr Phe Thr Ala Asp Thr Phe Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Ser Ala Ser Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  48
<211>  111
<212>  PRT
<213>  mus musculus 

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Phe Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  49
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  49
gaggtgaagc tgcagcagtc tggaactgag ttgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt agctactgga tagagtggat aaagcagagg      120

cctggacgtg gccttgagtg gattggagag attttacctg gaagtggtag tactaactac      180

aatgaggagt tcacgggcag ggccacattc actgcagata cattttccaa tacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgc aagatctgtt      300

tcggcttcca actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcgagc      360


<210>  50
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  50
gacattgtga tgacccaatc tccagcttcc ctagctgtgt ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagtt acagttatat gcactggtac      120

caacagaagc caggacagcc acccaaattc ctcatcaaat atgcatccaa cctggaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattcctccc      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  51
<211>  5
<212>  PRT
<213>  mus musculus 

<400>  51

Asp Tyr Ser Met His 
1               5   


<210>  52
<211>  17
<212>  PRT
<213>  mus musculus 

<400>  52

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  53

Glu Asp Tyr Tyr Gly His Asp Gly Phe Leu Tyr 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  mus musculus 

<400>  54

Lys Ala Ser Gln Asp Val Val Thr Thr Val Ala 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  mus musculus 

<400>  55

Trp Ala Ser Leu Arg His Thr 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  mus musculus 

<400>  56

Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  57
<211>  120
<212>  PRT
<213>  mus musculus 

<400>  57

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Asp Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Gly His Asp Gly Phe Leu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  58
<211>  107
<212>  PRT
<213>  mus musculus 

<400>  58

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Val Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Leu Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Phe 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  59
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  59
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggtta taccttcaca gactattcaa tgcactgggt gaagcaggct      120

ccaggaaagg atttaaagtg gatgggctgg ataaacactg agactggtga gccaacatat      180

gcagatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc tagagaggac      300

tactatggtc acgacgggtt tctttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  60
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  60
gacattgtga tgacccagtc tcacaaattc atgtccactt cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtggtt actactgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccctcc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagttt      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  61
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  61

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Phe Leu 
        35                  40                  45              


Gly Tyr Ile Ser Phe Ala Asp Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asp Tyr Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  62
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  62

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  63
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Ser Leu Asn Thr His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Thr Gly Ser Gly Glu Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Ile Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Tyr Asp Ser Thr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Arg Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Pro Ile 
        35                  40                  45              


Tyr Arg Ala Asp Arg Ser Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  65
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  65

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Gly His Asp Gly Phe Leu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  66
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Thr Thr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Leu Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  67
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  67

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ala Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Ala Ala Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  68
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  68

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  69
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  69

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


