                         SEQUENCE LISTING

<110>  Century Therapeutics, Inc.
 
<120>  GENE TRANSFER VECTORS AND METHODS OF ENGINEERING CELLS

<130>  CNTY-008-WO-01

<150>  63/171,891
<151>  2021-04-07

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 VH

<400>  2

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Whitlow Linker

<400>  3

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 VL

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  5
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  7
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FMC63 scFV

<400>  7

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys 
        115                 120                 125             


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu 
            180                 185                 190         


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Thr 
                245 


<210>  8
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  9

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  10
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  11
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  12
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg 
1               5                   10                  15      


Leu Arg Arg Glu Ser Val Arg Pro Val 
            20                  25  


<210>  13
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr 
1               5                   10                  15      


Asn Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
            20                  25                  30          


Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser 
        35                  40                  45              


Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
    50                  55                  60      


<210>  14
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  15
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  16
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser 
    50      


<210>  17
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  18
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  18

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  19
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  19

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  20
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  21
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  22
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  23
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  24
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  24

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3

<400>  26

Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10                  15      


Thr Gly Gly Ser 
            20  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4

<400>  27

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5

<400>  28

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 6

<400>  29

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 7

<400>  30

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 8

<400>  31

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 9

<400>  32

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  33
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 10

<400>  33

Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala 
1               5                   10                  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 11

<400>  34

Gly Lys Gly Gly Ser Gly Lys Gly Gly Ser Gly Lys Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 12

<400>  35

Gly Gly Lys Gly Ser Gly Gly Lys Gly Ser Gly Gly Lys Gly Ser 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 13

<400>  36

Gly Gly Gly Lys Ser Gly Gly Gly Lys Ser Gly Gly Gly Lys Ser 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 14

<400>  37

Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 15

<400>  38

Gly Gly Gly Lys Ser Gly Gly Lys Gly Ser Gly Lys Gly Gly Ser 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 16

<400>  39

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 
1               5                   10                  15  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 17

<400>  40

Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly 
1               5                   10                  15      


Lys Pro Gly Ser 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 18

<400>  41

Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser Gly Lys Gly Lys Ser Gly 
1               5                   10                  15      


Lys Gly Lys Ser 
            20  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 19

<400>  42

Ser Thr Ala Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp 
1               5                   10                  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 20

<400>  43

Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser Gly Glu Gly Gly Ser 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 21

<400>  44

Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser Gly Gly Glu Gly Ser 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 22

<400>  45

Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 23

<400>  46

Gly Gly Gly Glu Ser Gly Gly Glu Gly Ser Gly Glu Gly Gly Ser 
1               5                   10                  15  


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 24

<400>  47

Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser Gly Glu Gly Glu Ser Gly 
1               5                   10                  15      


Glu Gly Glu Ser 
            20  


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 26

<400>  48

Pro Arg Gly Ala Ser Lys Ser Gly Ser Ala Ser Gln Thr Gly Ser Ala 
1               5                   10                  15      


Pro Gly Ser 
            


<210>  49
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 27

<400>  49

Gly Thr Ala Ala Ala Gly Ala Gly Ala Ala Gly Gly Ala Ala Ala Gly 
1               5                   10                  15      


Ala Ala Gly 
            


<210>  50
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 28

<400>  50

Gly Thr Ser Gly Ser Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly 
            


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 30

<400>  51

Gly Ser Gly Ser 
1               


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 31

<400>  52

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10  


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 32

<400>  53

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  54
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 33

<400>  54

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Ala Ala Ala 
            20                  25                  30          


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  55

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  56

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  57
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  57

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  58

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  59
tttatctgtc ccctccaccc caca                                              24


<210>  60
<211>  1205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 Left Homology Arm

<400>  60
actctgcccc aggcctcctt accattcccc ttcgacctac tctcttccgc attggagtcg       60

ctttaactgg ccctggcttt ggcagcctgt gctgacccat gcagtcctcc ttaccatccc      120

tccctcgact tcccctcttc cgatgttgag cccctccagc cggtcctgga ctttgtctcc      180

ttccctgccc tgccctctcc tgaacctgag ccagctccca tagctcagtc tggtctatct      240

gcctggccct ggccattgtc actttgcgct gccctcctct cgcccccgag tgcccttgct      300

gtgccgccgg aactctgccc tctaacgctg ccgtctctct cctgagtccg gaccactttg      360

agctctactg gcttctgcgc cgcctctggc ccactgtttc cccttcccag gcaggtcctg      420

ctttctctga cctgcattct ctcccctggg cctgtgccgc tttctgtctg cagcttgtgg      480

cctgggtcac ctctacggct ggcccagatc cttccctgcc gcctccttca ggttccgtct      540

tcctccactc cctcttcccc ttgctctctg ctgtgttgct gcccaaggat gctctttccg      600

gagcacttcc ttctcggcgc tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc      660

tgggtcctct ccgggcatct ctcctccctc acccaacccc atgccgtctt cactcgctgg      720

gttccctttt ccttctcctt ctggggcctg tgccatctct cgtttcttag gatggccttc      780

tccgacggat gtctcccttg cgtcccgcct ccccttcttg taggcctgca tcatcaccgt      840

ttttctggac aaccccaaag taccccgtct ccctggcttt agccacctct ccatcctctt      900

gctttctttg cctggacacc ccgttctcct gtggattcgg gtcacctctc actcctttca      960

tttgggcagc tcccctaccc cccttacctc tctagtctgt gctagctctt ccagccccct     1020

gtcatggcat cttccagggg tccgagagct cagctagtct tcttcctcca acccgggccc     1080

ctatgtccac ttcaggacag catgtttgct gcctccaggg atcctgtgtc cccgagctgg     1140

gaccacctta tattcccagg gccggttaat gtggctctgg ttctgggtac ttttatctgt     1200

cccct                                                                 1205


<210>  61
<211>  1200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVS1 Right Homology Arm

<400>  61
ccaccccaca gtggggccac tagggacagg attggtgaca gaaaagcccc atccttaggc       60

ctcctccttc ctagtctcct gatattgggt ctaaccccca cctcctgtta ggcagattcc      120

ttatctggtg acacaccccc atttcctgga gccatctctc tccttgccag aacctctaag      180

gtttgcttac gatggagcca gagaggatcc tgggagggag agcttggcag ggggtgggag      240

ggaagggggg gatgcgtgac ctgcccggtt ctcagtggcc accctgcgct accctctccc      300

agaacctgag ctgctctgac gcggccgtct ggtgcgtttc actgatcctg gtgctgcagc      360

ttccttacac ttcccaagag gagaagcagt ttggaaaaac aaaatcagaa taagttggtc      420

ctgagttcta actttggctc ttcacctttc tagtccccaa tttatattgt tcctccgtgc      480

gtcagtttta cctgtgagat aaggccagta gccagccccg tcctggcagg gctgtggtga      540

ggaggggggt gtccgtgtgg aaaactccct ttgtgagaat ggtgcgtcct aggtgttcac      600

caggtcgtgg ccgcctctac tccctttctc tttctccatc cttctttcct taaagagtcc      660

ccagtgctat ctgggacata ttcctccgcc cagagcaggg tcccgcttcc ctaaggccct      720

gctctgggct tctgggtttg agtccttggc aagcccagga gaggcgctca ggcttccctg      780

tcccccttcc tcgtccacca tctcatgccc ctggctctcc tgccccttcc ctacaggggt      840

tcctggctct gctcttcaga ctgagccccg ttcccctgca tccccgtacc cctgcatccc      900

ccttcccctg catcccccag aggccccagg ccacctactt ggcctggacc ccacgagagg      960

ccaccccagc cctgtctacc aggctgcctt ttgggtggat tctcctccaa ctgtggggtg     1020

actgcttggc aaactcactc ttcggggtat cccaggaggc ctggagcatt ggggtgggct     1080

ggggttcaga gaggagggat tcccttctca ggttacgtgg ccaagaagca ggggagctgg     1140

gtttgggtca ggtctgggtg tggggtgacc agcttatgct gtttgcccag gacagcctag     1200


<210>  62
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  62
tttactcacg tcatccagca gaga                                              24


<210>  63
<211>  1042
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Left Homology Arm

<400>  63
gcatataaaa cctcagcaga aataaagagg ttttgttgtt tggtaagaac ataccttggg       60

ttggttgggc acggtggctc gtgcctgtaa tcccaacact ttgggaggcc aaggcaggct      120

gatcacttga agttgggagt tcaagaccag cctggccaac atggtgaaat cccgtctcta      180

ctgaaaatac aaaaattaac caggcatggt ggtgtgtgcc tgtagtccca ggaatcactt      240

gaacccagga ggcggaggtt gcagtgagct gagatctcac cactgcacac tgcactccag      300

cctgggcaat ggaatgagat tccatcccaa aaaataaaaa aataaaaaaa taaagaacat      360

accttgggtt gatccactta ggaacctcag ataataacat ctgccacgta tagagcaatt      420

gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag      480

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      540

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      600

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      660

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      720

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      780

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      840

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      900

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      960

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactcca     1020

aagattcagg tttactcacg tc                                              1042


<210>  64
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M Right Homology Arm

<400>  64
atccagcaga gaatggaaag tcaaatttcc tgaattgcta tgtgtctggg tttcatccat       60

ccgacattga agttgactta ctgaagaatg gagagagaat tgaaaaagtg gagcattcag      120

acttgtcttt cagcaaggac tggtctttct atctcttgta ctacactgaa ttcaccccca      180

ctgaaaaaga tgagtatgcc tgccgtgtga accatgtgac tttgtcacag cccaagatag      240

ttaagtgggg taagtcttac attcttttgt aagctgctga aagttgtgta tgagtagtca      300

tatcataaag ctgctttgat ataaaaaagg tctatggcca tactaccctg aatgagtccc      360

atcccatctg atataaacaa tctgcatatt gggattgtca gggaatgttc ttaaagatca      420

gattagtggc acctgctgag atactgatgc acagcatggt ttctgaacca gtagtttccc      480

tgcagttgag cagggagcag cagcagcact tgcacaaata catatacact cttaacactt      540

cttacctact ggcttcctct agcttttgtg gcagcttcag gtatatttag cactgaacga      600

acatctcaag aaggtatagg cctttgtttg taagtcctgc tgtcctagca tcctataatc      660

ctggacttct ccagtacttt ctggctggat tggtatctga ggctagtagg aagggcttgt      720

tcctgctggg tagctctaaa caatgtattc atgggtagga acagcagcct attctgccag      780

ccttatttct aaccatttta gacatttgtt agtacatggt attttaaaag taaaacttaa      840

tgtcttcctt ttttttctcc actgtctttt tcatagatcg agacatgtaa gcagcatcat      900

ggaggtaagt ttttgacctt gagaaaatgt ttttgtttca ctgtcctgag gactatttat      960

agacagctct aacatgataa ccctcactat gtggagaaca ttgacagagt aacattttag     1020

cag                                                                   1023


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  65
tttaccttgg ggctctgaca ggta                                              24


<210>  66
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA Left Homology Arm

<400>  66
acaggaggta accatttaac aagaaagcag agtgatgtta gattatagca agatactgtt       60

gactgtagaa ggctctgagg ctagagagct gctttctata aaacagagtg atcatatatt      120

agaagaggtg ttaaagacat gttcacacca agctgagact tcctccttga taccaccagg      180

aggatgggca gagactggaa aagacactaa ctttctccct atgggagtca gtattattta      240

gcatcacttt ggcgggtcac cccaaaccat ctgactacaa gggtaccata tttgggttaa      300

cactcttttg gtataattta tgttttagtc caatgtcttg ggatgaaaat gacaggtggg      360

ccacttatga tctccagaga aattcagggc aatttggtgt gggagtaggc atggtagagg      420

agagcagcat ctaagaagtc cccagcagag gctctcagct tgtcttgagg catctgggcg      480

gagggctatg atactggccc catcctgcag aaggtggcag atattggcag ctggcaccag      540

tgcggttcca ttgtgatcat catttctgaa cgtcagactg ttgaaggttc ccccaacaga      600

ctttctgtgc aactttctgt cttcaccaaa ttcagtccac agtaaggaag tgaaattaat      660

ttcagaggtg tggggagggc ttaagggagt gtggtaaaat tagagggtgt tcagaaacag      720

aaatctgacc gcttggggcc accttgcagg gagagttttt ttgatgatcc ctcacttgtt      780

tctttgcatg ttggcttagc ttggcgggct cccaactggt gactggttag tgatgaggct      840

agtgatgagg ctgtgtgctt ctgagctggg catccgaagg catccttggg gaagctgagg      900

gcacgaggag gggctgccag actccgggag ctgctgcctg gctgggattc ctacacaatg      960

cgttgcctgg ctccacgccc tgctgggtcc tacctgtcag                           1000


<210>  67
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA Right Homology Arm

<400>  67
agccccaagg taaaaaggcc gggaaagcat cttaatttag cgtgcagtct cagctggtcc       60

tgccattcca gataaacaga gaaaccattc tgaattgggg atgggggtga ggatgggaac      120

aggagtctgt gtcctgctgg ggcaggccat tggaagatgt gaaagagttg tctatttcct      180

tccaccggag ggagacttca ggtcagccag gtgtctggag tatgaaccat gtatcagcac      240

cgaaaggttc tagaagtcag actttcgggc agtgtgtcac taactctcag catgctggcc      300

tggctcggcc cacagcaagg tcttctcgcc tccctttggg taaatactga ggggtgcctc      360

tgcaggacgg gacctctgcc agactccact ccatacccag agaagcaggg aaaccaaaat      420

tggagtcagc cttgaggtgt agctgttgag ccctcagcag ctggggagag ctggcggatg      480

ctgccctccc cccagtttcc taatggtgtt gtttaaaaag ggtcagggga cgggggaaca      540

gatggtggga agagcacagt gcagacacct ggcaccggct ctgaaggcag catggcagct      600

acaccgttgg ctgggaaggg tgtgcccctg aagaagtcgt ttacattctc gagtcaattt      660

tcctggagtg tacaatggac ctgtgggaaa gcctgtatga aagggtaatg atgagggacc      720

tagcacagtg tccaatattt tataggaact ggaattgagc tcataggagc tcaattttat      780

tggcattgct gttgttggat ggttaaaggg gtggtatccc ttttctcaga ctcccctgaa      840

atgtatggtt tgctttgaac ccagagactg atgacaggtc tgccggtgtg gttgggtgca      900

gccttaagtt gctacgggaa agtgttggag ggggagaagt cagaggtaac cttgccccct      960

ccctcaattc cagatgagga aattcaggcc tgaaaaggga                           1000


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  68
agagtgatca cagctctgac taaa                                              24


<210>  69
<211>  1046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLYBL Left Homology Arm

<400>  69
gtccagactc aggaggactt agttctcttc ataaaaagtt gatcaccttt gctttctcct       60

ttgcatgggc aataaagaag tgaaaaataa attcccagtg agcttgcatt ctgcttggga      120

acaacatagc acatccattt tctagagagc tgtccagtcc ccatttgagg gctgctagcc      180

acatgtcaag caggaaccca gagtataacc aggaaaatgt ctgtggtaga ccccagtgat      240

tcatgcctcc catctccaca ccctcctgta gtcccctccc acgctgattc tggactaggc      300

cacatggctt ggccagtgga acacatgcag gcttgcacgt ctggaactct gccacctaat      360

ttaggatccc agactctcct actggagaca caggtcctta gtgacagtct gcaccaccat      420

tcagacaagt cagtagggcc atcttagatc atccagccct agtcaagcca ccagataact      480

gtacccacat aagtgacccc tggcgagacc agcaggagaa tcatgccaat gggccaatat      540

acattctgac ccacagtttc ataataaaat aaaatggttg tggttgtaag ccactatgtt      600

tcagagtggt ttgttacaca gcaataaata actaatatag taggcatacc atcaagtcca      660

aagtaggtag agaagaatgt aaatagcaga gcaaaacagc atgactggtg gctgggaggc      720

ttaaaactgg gacaggatca gagtcatgaa agaagtcaaa gaaatggttc agaagtaagg      780

ctgagactga cttacaaaag ctgaaagtcc ctttaagttg gtgtttggtg cattggcagg      840

ggcaggtatg gtgacttaaa agagccatgc tcaacaagat caagcacaac acaatcacgg      900

gtcaccccag cagaccttag cgagtctagc catttctttg gtggtggtca cagtcatgct      960

tcagcccagt ttccacttgg acaaatggta catattttca atgagatgaa aattaagata     1020

caatccatgt gctcagagag tgatca                                          1046


<210>  70
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CLYBL Right Homology Arm

<400>  70
atcatgtctg ctcgacagct ctgactaaac actgtgcccc aaagtgttga ggaattggga       60

aaacctagct gagttagtgg tctcttttct gttacaataa agctcataat gaaaattagc      120

cttctttgtt cttccccaag tctttctttc tagacgaaac tactttcaac tgttttaact      180

tccttactgt taacttccat atttctagat agtatggtca gactgttatt tcttgacttt      240

taaatgtaag atattatcta ctgacttcct tctatgtaag atgaggattg agctctctta      300

cccttctccc atttcctcat ccttccaaca taaatatatt ttgggattat atcaacattc      360

aatgttactt aaagtgacct tgtaaatatt ttcacaactg agccatgttt gatttgtata      420

cttatgttta ctttactgtt tttcctgaag ttaataattg ccttgaattt atttatttct      480

ttaaaaatgt ttcattactc aggactgtag tttacattac gattctttgt gttatacagt      540

tgatgggttt cttttctttc ttaatttctt taaaaaatag agatggggtc ttactatatt      600

acccaggctg gtcttgaagt cctgggctca agtgatcttc ctgtctcagc ctaccaagta      660

gctgagacta taggtgcaaa aaagccacta tacctggcta gtttacaggt tttaacaaat      720

gcattatgcc acgtatccat tattacagga tcacacaaga tattttcatt accctgaaag      780

catccctgtg ttccaccaat tcatcctgcc tccatgagcc gctggcaacc actgatctct      840

atagttttgc cttttctaaa atgtcatata attggaatca tacagtctgt agcattttca      900

gactagcttt taaaatttgg caatatgcat ttaaggttcc tccttaaatg tgaagggcat      960

agccaatgtg gcttgatagc tcatttcttt ttattggtga atatttcatt gtctggatgt     1020

tccacagttt gtttatcctc gagagcttgg cgt                                  1053


<210>  71
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  71
ctcagacctg aatctgcccc caaa                                              24


<210>  72
<211>  1045
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKG2A Left Homology Arm

<400>  72
gacctggcct ccgttttatg tagtgttcct aatactattt aggttatgca taagttaact       60

gtgtcacata gcattttctg tcatatacaa atatttaatt ttttataatt tttaataaat      120

aatttttaat aatttcttag aacatttcag ccattaagaa aagaccattt aattacctct      180

attgattttc attaatgtgt ataaattact aattaaaagt aatgtagtgc aagaaatttt      240

tatatatata tatgtcaact ttactattac tcatgtgcag accacatagt cttaaccatt      300

actggatttc aaaattaaca taaaaatgag tgcagaagtt tttctaatac aacattttaa      360

tttttaacac aggtaaaaca tcagacttta agaaatatat ttttattcct gaacttcttt      420

attccttagt aatttattgc ttctcattgc cccagcaata atattttgtc aaatgcagaa      480

aatttatctt ttttttttga gtcggagtct cactctgtcg cccaggctgg agtgcagtgg      540

cacaatctcc gctcactgca acctctgccg cccatgttca agagattctc ctgcctcagc      600

ctcccgagta gctaggacta caggcgcctg acatcatgcc cgactacttt ttgtattttt      660

agtagagacg gagtttcacc gtgttagcca ggatggtctc gatctcctga cctcgtgatc      720

ggcatgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccgc gcccggccta      780

aaaatctttt tttaaaacaa atattcataa gaaacgtgtt taggcttgaa gaaaatcaga      840

gaaagaactt tagattattt aatgcaaaat gagctccaat actcgttctc cacctcaccc      900

ttttaattgc actagggaat cctgtatata aaccatttat taacttctta actactgtta      960

ttatagagta cagtccctga catcacacac tgcagagatg gataaccaag gagtaatcta     1020

ctcagacctg aacggtacca acgcg                                           1045


<210>  73
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKG2A Right Homology Arm

<400>  73
aatctgcccc caaacccaaa gaggcagcaa cgaaaaccta aaggcaataa aaactccatt       60

ttagcaactg aacaggaaat aacctatgcg gaattaaacc ttcaaaaagc ttctcaggat      120

tttcaaggga atgacaaaac ctatcactgc aaaggtaaag catttaaaag atcctcaata      180

taacagtcta ggatgtgcag cttggggtac aggaatgtgg ggaaagagaa gggagtgctc      240

atatatcttc tatttgcaaa gatcagaatt ccaagttgag atatgctatt tcaatgtaaa      300

gtatgaagac tgattgaact cattgttgaa gtttgtagtc tttgtcaaat aattcatgga      360

gcattatttt tcctgaaaat tcaatggtat attattctga gaaaaagatt acaatgggag      420

atgagggttt ggggtccaag tttctctgta tgattcctgt gcattcaggt tctcttgtct      480

gtgaatcttc taaacgactg tatccacctc tcctttcgca ctgttcccat ttctctccct      540

gcagatttac catcagctcc agagaagctc attgttggga tcctgggaat tatctgtctt      600

atcttaatgg cctctgtggt aacgatagtt gttattccct gtaagtctat tttcgaagat      660

tacaagggga attttcacgt taatgattga atgtgcctct aaacatttca tattttcagg      720

gaatagagtt ctcattgtaa tgtatatatt tggactaaat gtggaatgat tattctgaat      780

ttgtcaaaga ataaatgaaa gaataattgt tgaaagtatt cgcttctgat gcaatcgtat      840

gtatatattt ggatttcata actcaaaaat atgttctagg agtctgaaaa accttactga      900

gaaatagaaa ttaatttttg aaagtagtta aatcaagaat tataagaact atatgagatg      960

gtgaaatttg gttctttaga tctatgaaat acttttccaa aaaaccacca ttactttatc     1020


<210>  74
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  74
gtgtaccagc tgagagactc taaa                                              24


<210>  75
<211>  1229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC Left Homology Arm

<400>  75
cgactctaga ctcgaagctg gatgtctgca ttgccgaggc caccagggct ggctcagcaa       60

ctgtcgggga atcaccaggg tctgagaaat cttgtgcgca tgtgaggggc tgtgggagca      120

gagaaccact gggtgggaaa ttctaatccc caccctgctg gaaactctct gggtggcccc      180

aacatgctaa tcctccggca aacctctgtt tcctcctcaa aaggcaggag gtcggaaaga      240

ataaacaatg agagtcacat taaaaacaca aaatcctacg gaaatactga agaatgagtc      300

tcagcactaa ggaaaagcct ccagcagctc ctgctttctg agggtgaagg atagacgctg      360

tggctctgca tgactcacta gcactctatc acggccatat tctggcaggg tcagtggctc      420

caactaacat ttgtttggta ctttacagtt tattaaatag atgtttatat ggagaagctc      480

tcatttcttt ctcagaagag cctggctagg aaggtggatg aggcaccata ttcattttgc      540

aggtgaaatt cctgagatgt aaggagctgc tgtgacttgc tcaaggcctt atatcgagta      600

aacggtagtg ctggggctta gacgcaggtg ttctgattta tagttcaaaa cctctatcaa      660

tgagagagca atctcctggt aatgtgatag atttcccaac ttaatgccaa cataccataa      720

acctcccatt ctgctaatgc ccagcctaag ttggggagac cactccagat tccaagatgt      780

acagtttgct ttgctgggcc tttttcccat gcctgccttt actctgccag agttatattg      840

ctggggtttt gaagaagatc ctattaaata aaagaataag cagtattatt aagtagccct      900

gcatttcagg tttccttgag tggcaggcca ggcctggccg tgaacgttca ctgaaatcat      960

ggcctcttgg ccaagattga tagcttgtgc ctgtccctga gtcccagtcc atcacgagca     1020

gctggtttct aagatgctat ttcccgtata aagcatgaga ccgtgacttg ccagccccac     1080

agagccccgc ccttgtccat cactggcatc tggactccag cctgggttgg ggcaaagagg     1140

gaaatgagat catgtcctaa ccctgatcct cttgtcccac agatatccag aaccctgacc     1200

ctgccgtgta ccagctcgag aaggatctg                                       1229


<210>  76
<211>  1130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC Right Homology Arm

<400>  76
atcatgtctg ggatctgaga gactctaaat ccagtgacaa gtctgtctgc ctattcaccg       60

attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca      120

aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg gcctggagca      180

acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca gaagacacct      240

tcttccccag cccaggtaag ggcagctttg gtgccttcgc aggctgtttc cttgcttcag      300

gaatggccag gttctgccca gagctctggt caatgatgtc taaaactcct ctgattggtg      360

gtctcggcct tatccattgc caccaaaacc ctctttttac taagaaacag tgagccttgt      420

tctggcagtc cagagaatga cacgggaaaa aagcagatga agagaaggtg gcaggagagg      480

gcacgtggcc cagcctcagt ctctccaact gagttcctgc ctgcctgcct ttgctcagac      540

tgtttgcccc ttactgctct tctaggcctc attctaagcc ccttctccaa gttgcctctc      600

cttatttctc cctgtctgcc aaaaaatctt tcccagctca ctaagtcagt ctcacgcagt      660

cactcattaa cccaccaatc actgattgtg ccggcacatg aatgcaccag gtgttgaagt      720

ggaggaatta aaaagtcaga tgaggggtgt gcccagagga agcaccattc tagttggggg      780

agcccatctg tcagctggga aaagtccaaa taacttcaga ttggaatgtg ttttaactca      840

gggttgagaa aacagctacc ttcaggacaa aagtcaggga agggctctct gaagaaatgc      900

tacttgaaga taccagccct accaagggca gggagaggac cctatagagg cctgggacag      960

gagctcaatg agaaaggaga agagcagcag gcatgagttg aatgaaggag gcagggccgg     1020

gtcacagggc cttctaggcc atgagagggt agacagtatt ctaaggacgc cagaaagctg     1080

ttgatcggct tcaagcaggg gagggacacc taattgatcc gatccgagct                1130


<210>  77
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tEGFR

<400>  77

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Gly Val Arg Lys Cys Lys Lys Cys 
            20                  25                  30          


Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe 
        35                  40                  45              


Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn 
    50                  55                  60                  


Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg 
65                  70                  75                  80  


Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp 
                85                  90                  95      


Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala 
            100                 105                 110         


Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile 
        115                 120                 125             


Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val 
    130                 135                 140                 


Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser 
145                 150                 155                 160 


Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn 
                165                 170                 175     


Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys 
            180                 185                 190         


Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val 
        195                 200                 205             


Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg 
    210                 215                 220                 


Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp 
225                 230                 235                 240 


Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser 
                245                 250                 255     


Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile 
            260                 265                 270         


Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr 
        275                 280                 285             


Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly 
    290                 295                 300                 


Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys 
305                 310                 315                 320 


His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu 
                325                 330                 335     


Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly 
            340                 345                 350         


Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly 
        355                 360                 365             


Leu Phe Met 
    370     


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  78

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  79
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-15

<400>  79

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence

<400>  80

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  81
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD79b Epitope

<400>  81

Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser 
1               5                   10                  15      


Arg Ile Trp Gln Ser 
            20      


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 Mimitope

<400>  82

Ala Cys Pro Tyr Ala Asn Pro Ser Leu Cys 
1               5                   10  


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  83

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  84
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ErbB Epitope

<400>  84

Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly 
1               5                   10                  15      


Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln 
            20                  25                  30          


Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr 
        35                  40                  45              


Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln 
    50                  55                  60                  


Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala 
65                  70                  75                  80  


Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser 
                85                  90                  95      


Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp 
            100                 105                 110         


Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys 
        115                 120                 125             


Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro 
    130                 135                 140                 


Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val 
145                 150                 155                 160 


Leu Gly Val Val Phe Gly Ile Leu Ile Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


<210>  85
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 Amino Acid Sequence

<400>  85

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  86
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tEGFR-P2A-IL15 Amino Acid Sequence

<400>  86

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Gly Val Arg Lys Cys Lys Lys Cys 
            20                  25                  30          


Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe 
        35                  40                  45              


Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn 
    50                  55                  60                  


Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg 
65                  70                  75                  80  


Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp 
                85                  90                  95      


Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala 
            100                 105                 110         


Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile 
        115                 120                 125             


Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val 
    130                 135                 140                 


Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser 
145                 150                 155                 160 


Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn 
                165                 170                 175     


Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys 
            180                 185                 190         


Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val 
        195                 200                 205             


Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg 
    210                 215                 220                 


Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp 
225                 230                 235                 240 


Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser 
                245                 250                 255     


Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile 
            260                 265                 270         


Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr 
        275                 280                 285             


Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly 
    290                 295                 300                 


Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys 
305                 310                 315                 320 


His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu 
                325                 330                 335     


Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly 
            340                 345                 350         


Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly 
        355                 360                 365             


Leu Phe Met Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Ser Lys Pro 
385                 390                 395                 400 


His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn 
                405                 410                 415     


Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys 
            420                 425                 430         


Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile 
        435                 440                 445             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    450                 455                 460                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
465                 470                 475                 480 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                485                 490                 495     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            500                 505                 510         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        515                 520                 525             


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    530                 535                 540                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
545                 550                 555     


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  87

Gly Gly Gly Gly Ser 
1               5   


<210>  88
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD79b-P2A-IL15

<400>  88

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser 
            20                  25                  30          


Ala Cys Ser Arg Ile Trp Gln Ser Thr Thr Thr Pro Ala Pro Arg Pro 
        35                  40                  45              


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    50                  55                  60                  


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
65                  70                  75                  80  


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                85                  90                  95      


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Ala Thr Asn Phe Ser Leu 
            100                 105                 110         


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
        115                 120                 125             


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
    130                 135                 140                 


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
145                 150                 155                 160 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val 
                165                 170                 175     


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
            180                 185                 190         


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
        195                 200                 205             


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
    210                 215                 220                 


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
225                 230                 235                 240 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
                245                 250                 255     


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
            260                 265                 270         


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        275                 280                 285         


<210>  89
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD20 Mimitope-P2A-IL15

<400>  89

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Ala Cys Pro Tyr Ala Asn Pro Ser Leu Cys Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Ala Cys Pro Tyr Ala Asn Pro Ser Leu 
        35                  40                  45              


Cys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                85                  90                  95      


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            100                 105                 110         


Val Ile Thr Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        115                 120                 125             


Glu Glu Asn Pro Gly Pro Met Arg Ile Ser Lys Pro His Leu Arg Ser 
    130                 135                 140                 


Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu 
145                 150                 155                 160 


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
                165                 170                 175     


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            180                 185                 190         


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        195                 200                 205             


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    210                 215                 220                 


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
225                 230                 235                 240 


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                245                 250                 255     


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            260                 265                 270         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        275                 280                 285             


Val Gln Met Phe Ile Asn Thr Ser 
    290                 295     


<210>  90
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ErbB Epitope-P2A-IL15

<400>  90

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly His 
            20                  25                  30          


Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe Leu 
        35                  40                  45              


Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu Pro 
    50                  55                  60                  


Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu Cys 
65                  70                  75                  80  


Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln 
                85                  90                  95      


Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg 
            100                 105                 110         


Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys 
        115                 120                 125             


Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr 
    130                 135                 140                 


His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg 
145                 150                 155                 160 


Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu 
                165                 170                 175     


Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile Gly Gly Gly Gly 
            180                 185                 190         


Ser Gly Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        195                 200                 205             


Glu Glu Asn Pro Gly Pro Met Arg Ile Ser Lys Pro His Leu Arg Ser 
    210                 215                 220                 


Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu 
225                 230                 235                 240 


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
                245                 250                 255     


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            260                 265                 270         


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        275                 280                 285             


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    290                 295                 300                 


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
305                 310                 315                 320 


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                325                 330                 335     


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            340                 345                 350         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        355                 360                 365             


Val Gln Met Phe Ile Asn Thr Ser 
    370                 375     


<210>  91
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-E

<400>  91

His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly 
1               5                   10                  15      


Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val 
            20                  25                  30          


Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg Ala Pro 
        35                  40                  45              


Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser 
    50                  55                  60                  


Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr Leu Arg 
65                  70                  75                  80  


Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp Met 
                85                  90                  95      


His Gly Cys Glu Leu Gly Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu 
            100                 105                 110         


Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu 
        115                 120                 125             


Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys 
    130                 135                 140                 


Ser Asn Asp Ala Ser Glu Ala Glu His Gln Arg Ala Tyr Leu Glu Asp 
145                 150                 155                 160 


Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys Glu Thr 
                165                 170                 175     


Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His Pro Ile 
            180                 185                 190         


Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
        195                 200                 205             


Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His Thr Gln 
    210                 215                 220                 


Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
225                 230                 235                 240 


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
                245                 250                 255     


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Val Thr Leu Arg Trp 
            260                 265                 270         


Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly 
        275                 280                 285             


Leu Val Leu Leu Gly Ser Val Val Ser Gly Ala Val Val Ala Ala Val 
    290                 295                 300                 


Ile Trp Arg Lys Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys 
305                 310                 315                 320 


Ala Glu Trp Ser Asp Ser Ala Gln Gly Ser Glu Ser His Ser Leu 
                325                 330                 335 


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G Signal Peptide

<400>  92

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Val Met Ala Pro Arg Thr Leu Ile 
            20                  25                  30          


Leu 
    


<210>  93
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G Signal Peptide-B2M-HLA-E Amino Acid

<400>  93

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Val Met Ala Pro Arg Thr Leu Ile 
            20                  25                  30          


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser 
    50                  55                  60                  


Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val 
65                  70                  75                  80  


Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly 
                85                  90                  95      


Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp 
            100                 105                 110         


Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys 
        115                 120                 125             


Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys 
    130                 135                 140                 


Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Leu Lys Tyr Phe His 
                165                 170                 175     


Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val 
            180                 185                 190         


Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala 
        195                 200                 205             


Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser 
    210                 215                 220                 


Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile 
225                 230                 235                 240 


Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
                245                 250                 255     


Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro 
            260                 265                 270         


Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys 
        275                 280                 285             


Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp 
    290                 295                 300                 


Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala 
305                 310                 315                 320 


Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His 
                325                 330                 335     


Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro 
            340                 345                 350         


Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu 
        355                 360                 365             


Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp 
    370                 375                 380                 


Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr 
385                 390                 395                 400 


Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
                405                 410                 415     


Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
            420                 425                 430         


Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr 
        435                 440                 445             


Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val 
    450                 455                 460                 


Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser 
465                 470                 475                 480 


Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala 
                485                 490                 495     


Gln Gly Ser Glu Ser His Ser Leu 
            500                 


<210>  94
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-G Signal Peptide-B2M-HLA-E Nucleotide

<400>  94
atggtggtca tggcccctag aacactgttc ctgctgctgt ctggcgccct gacactgaca       60

gagacatggg ccgtgatggc ccccagaacc ctgatcctgg gcggcggtgg ttcaggcgga      120

ggaggttcag gaggaggggg tagtggaggt ggtggttcta tccagcggac ccctaagatc      180

caggtgtaca gcagacaccc cgccgagaac ggcaagagca acttcctgaa ctgctacgtg      240

tccggctttc accccagcga cattgaggtg gacctgctga agaacggcga gcggatcgag      300

aaggtggaac acagcgatct gagcttcagc aaggactggt ccttctacct gctgtactac      360

accgagttca cccctaccga gaaggacgag tacgcctgca gagtgaacca cgtgacactg      420

agccagccta agatcgtgaa gtgggatcgc gatatgggcg gaggcggatc tggtggcgga      480

ggaagtggcg gcggaggatc tggctcccac tccttgaagt atttccacac ttccgtgtcc      540

cggcccggcc gcggggagcc ccgcttcatc tctgtgggct acgtggacga cacccagttc      600

gtgcgcttcg acaacgacgc cgcgagtccg aggatggtgc cgcgggcgcc gtggatggag      660

caggaggggt cagagtattg ggaccgggag acacggagcg ccagggacac cgcacagatt      720

ttccgagtga atctgcggac gctgcgcggc tactacaatc agagcgaggc cgggtctcac      780

accctgcagt ggatgcatgg ctgcgagctg gggcccgacg ggcgcttcct ccgcgggtat      840

gaacagttcg cctacgacgg caaggattat ctcaccctga atgaggacct gcgctcctgg      900

accgcggtgg acacggcggc tcagatctcc gagcaaaagt caaatgatgc ctctgaggcg      960

gagcaccaga gagcctacct ggaagacaca tgcgtggagt ggctccacaa atacctggag     1020

aaggggaagg agacgctgct tcacctggag cccccaaaga cacacgtgac tcaccacccc     1080

atctctgacc atgaggccac cctgaggtgc tgggccctgg gcttctaccc tgcggagatc     1140

acactgacct ggcagcagga tggggagggc catacccagg acacggagct cgtggagacc     1200

aggcctgcag gggatggaac cttccagaag tgggcagctg tggtggtgcc ttctggagag     1260

gagcagagat acacgtgcca tgtgcagcat gaggggctac ccgagcccgt caccctgaga     1320

tggaagccgg cttcccagcc caccatcccc atcgtgggca tcattgctgg cctggttctc     1380

cttggatctg tggtctctgg agctgtggtt gctgctgtga tatggaggaa gaagagctca     1440

ggtggaaaag gagggagcta ctctaaggct gagtggagcg acagtgccca ggggtctgag     1500

tctcacagct tgtaa                                                      1515


<210>  95
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G

<400>  95

His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg Gly 
1               5                   10                  15      


Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe Val 
            20                  25                  30          


Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala Pro 
        35                  40                  45              


Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn 
    50                  55                  60                  


Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu Arg 
65                  70                  75                  80  


Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp Met 
                85                  90                  95      


Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu 
            100                 105                 110         


Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu 
        115                 120                 125             


Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys 
    130                 135                 140                 


Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly 
145                 150                 155                 160 


Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu Met 
                165                 170                 175     


Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val 
            180                 185                 190         


Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro 
        195                 200                 205             


Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
    210                 215                 220                 


Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
225                 230                 235                 240 


Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr 
                245                 250                 255     


Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp 
            260                 265                 270         


Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val Ala Gly 
        275                 280                 285             


Leu Val Val Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala Ala Val 
    290                 295                 300                 


Leu Trp Arg Lys Lys Ser Ser Asp 
305                 310         


<210>  96
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-G Signal Peptide-B2M-HLA-G

<400>  96

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Arg Ile Ile Pro Arg His Leu Gln 
            20                  25                  30          


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro 
        35                  40                  45              


Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn 
    50                  55                  60                  


Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val 
65                  70                  75                  80  


Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp 
                85                  90                  95      


Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu 
            100                 105                 110         


Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val 
        115                 120                 125             


Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His 
145                 150                 155                 160 


Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu 
                165                 170                 175     


Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg 
            180                 185                 190         


Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp 
        195                 200                 205             


Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr 
    210                 215                 220                 


Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly 
225                 230                 235                 240 


Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile 
                245                 250                 255     


Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln 
            260                 265                 270         


Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg 
        275                 280                 285             


Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys 
    290                 295                 300                 


Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr 
305                 310                 315                 320 


Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu 
                325                 330                 335     


Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val Phe 
            340                 345                 350         


Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala 
        355                 360                 365             


Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp 
    370                 375                 380                 


Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys 
385                 390                 395                 400 


Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys 
                405                 410                 415     


His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys 
            420                 425                 430         


Gln Ser Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu 
        435                 440                 445             


Val Val Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala Ala Val Leu 
    450                 455                 460                 


Trp Arg Lys Lys Ser Ser Asp 
465                 470     


<210>  97
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HLA-G Signal Peptide-B2M-HLA-G

<400>  97
gccaccatgg tggtcatggc gccccgaacc ctcttcctgc tgctctcggg ggccctgacc       60

ctgaccgaga cctgggcgcg gatcattccc cgacatctgc aactgggagg cggcggttca      120

ggagggggcg gatcgatcca acgcaccccc aagatccagg tctactccag acacccggcc      180

gaaaacggaa agtcgaactt cctgaactgc tatgtgtcag gattccaccc gtccgacatc      240

gaggtggacc tcctgaagaa cggcgaacgc attgagaagg tcgagcactc cgatctgtcg      300

ttctccaagg actggtcctt ctaccttctc tactataccg aattcacccc gaccgagaag      360

gacgaatacg cctgccgggt caaccacgtg accctgagcc agccaaagat cgtgaaatgg      420

gaccgcgata tgggaggagg aggttccggc ggaggaggaa gcggaggcgg aggttccggc      480

tcccactcca tgaggtattt cagcgccgcc gtgtcccggc ctggccgcgg agagcctcgc      540

ttcatcgcca tgggatacgt ggacgacacc cagttcgtca gattcgacag cgacagcgcc      600

tgtcctcgga tggaacctag agcaccttgg gtcgagcaag agggccctga gtactgggaa      660

gaagagacac ggaacaccaa ggctcacgcc cagaccgaca gaatgaacct gcagaccctg      720

cggggctact acaatcagtc tgaggccagc agccatactc tgcagtggat gatcggctgc      780

gatctgggct ctgatggcag actgctgaga ggctacgagc agtacgccta cgacggcaag      840

gattatctgg ccctgaacga ggacctgcgg tcttggacag ctgccgatac agccgctcag      900

atcagcaaga gaaagtgcga ggccgccaat gtggccgaac agagaagggc ttacctggaa      960

ggcacctgtg tggaatggct gcacagatac ctggaaaacg gcaaagagat gctgcagcgg     1020

gccgatcctc ctaagacaca tgtgacccac catcctgtgt tcgactacga ggccacactg     1080

agatgttggg ccctgggctt ttaccctgcc gagatcatcc tgacctggca gcgagatggc     1140

gaggatcaga cccaggatgt ggaactggtg gaaaccagac ctgccggcga cggcaccttt     1200

cagaaatggg ctgctgtggt ggtgcccagc ggagaggaac agagatacac ctgtcacgtg     1260

cagcacgagg gactgcctga acctctgatg ctgagatgga agcagagcag cctgcctaca     1320

atccccatca tgggaatcgt ggccggactg gtggttctgg ccgctgttgt tacaggtgct     1380

gcagtggctg ccgtgctgtg gcggaagaaa agcagcgact ga                        1422


<210>  98
<211>  1724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG Promoter

<400>  98
attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat       60

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      120

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      180

tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca gtacatcaag      240

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      300

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      360

tcatcgctat taccatgggt cgaggtgagc cccacgttct gcttcactct ccccatctcc      420

cccccctccc cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg      480

ggggcggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg      540

ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt      600

tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt      660

cgctgcgttg ccttcgcccc gtgccccgct ccgcgccgcc tcgcgccgcc cgccccggct      720

ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc ctccgggctg      780

taattagcgc ttggtttaat gacggctcgt ttcttttctg tggctgcgtg aaagccttaa      840

agggctccgg gagggccctt tgtgcggggg ggagcggctc ggggggtgcg tgcgtgtgtg      900

tgtgcgtggg gagcgccgcg tgcggcccgc gctgcccggc ggctgtgagc gctgcgggcg      960

cggcgcgggg ctttgtgcgc tccgcgtgtg cgcgagggga gcgcggccgg gggcggtgcc     1020

ccgcggtgcg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg     1080

ggtgagcagg gggtgtgggc gcggcggtcg ggctgtaacc cccccctgca cccccctccc     1140

cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtgcggggcg tggcgcgggg     1200

ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct     1260

cgggccgggg agggctcggg ggaggggcgc ggcggccccg gagcgccggc ggctgtcgag     1320

gcgcggcgag ccgcagccat tgccttttat ggtaatcgtg cgagagggcg cagggacttc     1380

ctttgtccca aatctggcgg agccgaaatc tgggaggcgc cgccgcaccc cctctagcgg     1440

gcgcgggcga agcggtgcgg cgccggcagg aaggaaatgg gcggggaggg ccttcgtgcg     1500

tcgccgcgcc gccgtcccct tctccatctc cagcctcggg gctgccgcag ggggacggct     1560

gccttcgggg gggacggggc agggcggggt tcggcttctg gcgtgtgacc ggcgggatat     1620

ctacgaagcg gccgccctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaa                      1724


<210>  99
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 Terminator

<400>  99
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

t                                                                      121


<210>  100
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tEGFR-P2A-IL15 Nucleotide Seqeuence

<400>  100
atgaggccct caggcactgc cggggccgcc ctcctggccc tgttagccgc tttgtgtcca       60

gcaagccgcg ccggagtgcg gaaatgtaag aaatgcgaag gaccctgccg gaaggtatgc      120

aacggcattg ggattggcga attcaaggac agcctgagca ttaatgctac aaacatcaag      180

cactttaaga attgcaccag cattagcggc gatctgcata tactgccagt ggctttccga      240

ggcgactctt ttactcatac ccctccgctg gaccctcaag agctggacat tctcaagact      300

gtgaaggaaa ttacggggtt tctgctcatt caggcctggc ctgaaaaccg cacggatttg      360

catgcctttg agaatctgga aataatcaga ggccggacga aacagcatgg ccagttcagc      420

ctcgcggtcg tctctttgaa tattacgtca ctcggcctca ggtccctcaa agagatttct      480

gatggcgatg tcatcatctc tggtaataag aatctgtgtt acgcaaatac catcaattgg      540

aagaagctct ttgggacctc aggtcaaaag actaaaatta tctccaaccg cggcgagaac      600

agctgtaagg ctacaggcca ggtttgccac gcgctctgct ccccagaggg ttgctggggg      660

cctgagccaa gggattgcgt ttcatgtcgc aacgtgtctc ggggcagaga atgcgtggat      720

aaatgtaacc tcttagaggg cgaacctcgc gagtttgttg agaactcaga atgtatacag      780

tgccaccccg aatgtcttcc tcaggccatg aatatcacat gcaccggacg cggaccagac      840

aactgtatcc aatgtgctca ctacattgac ggacctcatt gtgtgaaaac atgccccgca      900

ggagttatgg gagaaaacaa caccctcgtt tggaaatatg ccgatgcagg tcacgtatgt      960

cacctgtgcc acccaaactg cacttatggg tgcaccgggc cgggcctgga ggggtgccct     1020

acgaatggac caaaaattcc cagtattgca actgggatgg tcggggcact gttgttgctg     1080

cttgtggttg ccctcgggat aggcctgttt atgtctggct ccggcgccac caatttcagc     1140

ctgctgaaac aggcaggcga cgtcgaagaa aatccaggac caatgcgaat atcaaaacca     1200

cacttgcgca gcatttctat acagtgctat ttgtgcttgt tgctgaactc tcacttcctc     1260

acagaggctg ggatacacgt tttcatactt ggatgttttt cagctgggct gccgaagaca     1320

gaggcgaatt gggtgaatgt aatttcagac ctcaagaaga tcgaggatct catccagtcc     1380

atgcacatcg acgctactct gtacacagag agcgatgtcc acccttcttg taaggttacc     1440

gccatgaaat gcttcctttt ggaactccaa gtcatctcat tggaatcagg ggatgcgtcc     1500

attcatgaca ccgtggaaaa cctgataata ctggctaaca acagcttgtc aagtaatggg     1560

aatgttactg agtccggttg taaagaatgt gaagagctgg aggagaagaa cattaaggaa     1620

tttttgcaat cttttgtaca tattgttcag atgtttatta acacaagc                  1668


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)2

<400>  101

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  102
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)6

<400>  102

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  103
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)7

<400>  103

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  104
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)8

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  105
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  105
tttctgccca acttctgctg gcat                                              24


<210>  106
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA Ex5 Left Homology Arm Sequence

<400>  106
aaacttctac caccgtcacc tatctctcag ggtttcctaa acatactctg aacaagtttc       60

ctcactctgc cactgtgacc cagaaagcta tctgttctcc ttctcccaga ctctgcctca      120

tctttcaagg cctggttcca ggatcccttc ctccaggaag ccttccctga ttgccctatt      180

ccaccataca ccttttttct cggacttcat gtcatggtgc ctatattcca agggctctga      240

gccatgtacc cctttatata gttaccacta tttactgagt gcctactgta taccagctac      300

tgtgttggat gctctagatg tagaacctct aattatcacc atcgattcct gggtagtagg      360

cattatttat tcatcttaca cagatgagaa aatggaggcc cacagtggtt aaataagtag      420

cccaagattg cacagctagt agggctagtg gaaagtagag gtggaatttg aactcaaatc      480

ctgcagtaac tctaccattc tgccttgctc ttctttgtag cagtagataa gttttcatgg      540

atacatacct catccttttg attagattaa gggcccctgg agtgtcagtg ttcattcatt      600

tgtttgatca ttcattcatt caacaaacat ttcttgagtc cccactgtgt gccaggccca      660

gaggttcccc agcccaaggc ctggcacaca gtgggccttc agttagacct tgttgattga      720

ctgcgctttt ccttgtctgg gcagcggaac tggaccagta tgtcttccag gactcccagc      780

tggagggcct gagcaaggac attttcagta agtttgtggt gggtggggag gtcttggctc      840

agcctgcatt tcctgccttg ttccctgggg ggtgccctaa tacctgacga ccattcattg      900

atgggcagtc agacccctct ccccaaggtg ggtacaatag agactcacct tgggctttca      960

ttgattgtgt gagttggtct ctggtttttc tcaaagtaga gcacatagga ccagatgaag     1020

tgatcggtga gagtatggag atgccagcag                                      1050


<210>  107
<211>  1052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CIITA Ex5 Right Homology Arm Sequence

<400>  107
aagttgggca gaaaagtcag aaaagacgtg agtgagcccc tccctgatcc aacctagcct       60

tgcttgagac ctggcctttc cttgactcca aagcctgctg tgggtccaac ttgcttccct      120

cgctaagtcc tgtctggttg ggaggccctt taaaagccaa caggagcctt aaaatgtaca      180

tctgattatt tcatggccct gataaccctc caatggctac aaaatacatg ccacaaggcc      240

tgtatggccc ttcctccctc tccaaaccca ctatgagaca ccacacttca gccaccacca      300

gcttctccac tcctataacc catgtgccct ttcaagcctc ggggcctttg cagttgctat      360

agtctctatc tggaatgccc ttcccccagt tcttcccatg gctgactcct ttgaatcttt      420

ctggtgttgg ctaaactgtc acctcttcct ggaacccttc tctgaccatc cttccatgta      480

gattagctca gttattctca ccttgtgtgt ctttttcctt gcagtttagc actcattacc      540

atctggacat attttacgcc ttgctctccc actgtgagga cagggacctt gtctttcttg      600

ctcgtgactg tttccccagc atctagtgca gtgcctggta tgcagtagca cctcagtaga      660

tatctgttga atgaaaacat ctgtaaaatg ggtgtaacag ttaactgagt acttattatg      720

ggtctgacca tgtgtaagtc ctgtatctat ttattcagtt cttaaacagg tgaatcgcac      780

acagggtatg agattttaaa agtgcaaaga atattcagtg aaggctgggc gcagcggctc      840

acacctgtaa tcccagcagt ttgggaggcc aagggggacg gatcacttga ggtcaggagt      900

ttgatacctg cctggccaac atggtgaaac cgcgtctcta ccaaaaaata caaaaattag      960

ccgggtgtgg tggtgcacgc ctgtaatccc agctactcgg gaggctgagg caggagaatc     1020

gcttgaaccc aggaggtgga ggttgcagtg ag                                   1052


<210>  108
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  108
tttggtccca ttggtcgcgg gctt                                              24


<210>  109
<211>  973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD70 Ex1 Left Homology Arm Sequence

<400>  109
aaaaataaaa aataaaaata ttaacttaat ttaactttaa acaaaaaagc aggtggtctc       60

caagaatgca ggagataact gaccgggtgc agtgtctcat gcctttaatc ccagcacttt      120

ggaaggccaa ggcgggtgga tcacccaagg tcaggagttc aagtccagcc tggccaacat      180

ggtgaaaccc catctctact aaaaatacaa aaaattagcc aggcatggtg gcgcgcgcat      240

gttactccca gctactcgcg aggctcagac aggagaatcg cttgaaccca ggagatcgag      300

gttgcggcga gctgagatgg cgccactgca ctccagcctg ggtgacagag ggagacctcc      360

gtctcaaaaa caaaacaaat caaaaaaatg caggagaggg gtacacgaat atttggggag      420

cacccccaat tcttggatgt ctgctgtatc cccagtgcac agcacaatct aatccctaat      480

aaatgtgcag tggaggtttg ttgaataaat gaatgggccc cagaagaatg aggtggagag      540

gggaatagga agattgaatg tctcctgcct gaaggtcggg cggggagggg ttgggggcag      600

gcaactctga ggctcacccg gggccactgc ctgcatcctg gcaactgcct ccacccactt      660

taggatcttc agactggcag cggttggagg gaatttcccc tcgccaattg ctcaagtccc      720

tcccctcgac cggccggaca tccccagaga ggggcaggct ggtcccctga caggttgaag      780

caagtagacg cccaggagcc ccgggagggg gctgcagttt ccttccttcc ttctcggcag      840

cgctccgcgc ccccatcgcc cctcctgcgc tagcggaggt gatcgccgcg gcgatgccgg      900

aggagggttc gggctgctcg gtgcggcgca ggccctatgg gtgcgtcctg cgggctgctt      960

tggtcccatt ggt                                                         973


<210>  110
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD70 Ex1 Right Homology Arm Sequence

<400>  110
cgcgggcttg gtgatctgcc tcgtggtgtg catccagcgc ttcgcacagg ctcagcagca       60

gctgccgctc gagtcacttg gggtgagttg agatggaaaa gttgggaaga aaacatagag      120

aggcgcgtga ccgaaaagac agaatgagat gggtacaaag aggccagaga ggaagatctg      180

gtagggcaga gacagagacc agaacaggga ggcgaggcgg ggaccaggct gcccggtgta      240

ggggctacga gacaggcagc cctgccagga ggtacaggga gatcccggga tgggaaaggt      300

aggcacacat ggaaatggaa gatgactcgg ctctggtgtt cccccggcag gctgactcag      360

aggctgctgg gggcttcaca aggctgggcg tgggggcttc ctggggcctc ctaggacggg      420

atggccccag ccactcgctc cgggtggggg aggggtccct ttggggaccg cgccgggcgc      480

ctttgcagcg tagagagtcc gctgcgcgcg gtgctctcgc gcccagtgac atccaggaaa      540

acgattcggg aaacgaagaa gttcttttga aggtctcgac ttcacgttcc ccgctggttc      600

agacctgctt cctctttaag aagtcttaag agtaaaaaaa aataaaatga aataaaatca      660

ccagtgcgcg ccgtgggatg agaggtggaa aggaggatgg acagagaaaa gagagctcct      720

ggcacagggg acacatagaa cctctctgct tacgtccgtg ccctgttttc tggtcttttc      780

ttccagtggg acgtagctga gctgcagctg aatcacacag gtaacacggg ggacgtggag      840

ggacggggag aagaagaggc acagagagag aaggaaggag aggtagaaag acaagtgggg      900

agagacagag agaaagagac acagacagag acggagggag agagggaggg agagataggg      960

agggaaacgg agagggggag acagagagaa gacagagagg                           1000


<210>  111
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  111
tttcccgaga ccgtcctggc gcg                                               23


<210>  112
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  112
tttgtctgca gggaaacaag agacc                                             25


<210>  113
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeting domain

<400>  113
tttggagtgg ccgggttcta gagtg                                             25


<210>  114
<211>  3792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT MAD7 nucleic acid sequence

<400>  114
atgaataatg gaacaaataa ctttcagaat tttatcggaa tttcttcttt gcagaagact       60

cttaggaatg ctctcattcc aaccgaaaca acacagcaat ttattgttaa aaacggaata      120

attaaagaag atgagctaag aggagaaaat cgtcagatac ttaaagatat catggatgat      180

tattacagag gtttcatttc agaaacttta tcgtcaattg atgatattga ctggacttct      240

ttatttgaga aaatggaaat tcagttaaaa aatggagata acaaagacac tcttataaaa      300

gaacagactg aataccgtaa ggcaattcat aaaaaatttg caaatgatga tagatttaaa      360

aatatgttca gtgcaaaatt aatctcagat attcttcctg aatttgtcat tcataacaat      420

aattattctg catcagaaaa ggaagaaaaa acacaggtaa ttaaattatt ttccagattt      480

gcaacgtcat tcaaggacta ttttaaaaac agggctaatt gtttttcggc tgatgatata      540

tcttcatctt cttgtcatag aatagttaat gataatgcag agatattttt tagtaatgca      600

ttggtgtata ggagaattgt aaaaagtctt tcaaatgatg atataaataa aatatccgga      660

gatatgaagg attcattaaa ggaaatgtct ctggaagaaa tttattctta tgaaaaatat      720

ggggaattta ttacacagga aggtatatct ttttataatg atatatgtgg taaagtaaat      780

tcatttatga atttatattg ccagaaaaat aaagaaaaca aaaatctcta taagctgcaa      840

aagcttcata aacagatact gtgcatagca gatacttctt atgaggtgcc gtataaattt      900

gaatcagatg aagaggttta tcaatcagtg aatggatttt tggacaatat tagttcgaaa      960

catatcgttg aaagattgcg taagattgga gacaactata acggctacaa tcttgataag     1020

atttatattg ttagtaaatt ctatgaatca gtttcacaaa agacatatag agattgggaa     1080

acaataaata ctgcattaga aattcattac aacaatatat tacccggaaa tggtaaatct     1140

aaagctgaca aggtaaaaaa agcggtaaag aatgatctgc aaaaaagcat tactgaaatc     1200

aatgagcttg ttagcaatta taaattatgt tcggatgata atattaaagc tgagacatat     1260

atacatgaaa tatcacatat tttgaataat tttgaagcac aggagcttaa gtataatcct     1320

gaaattcatc tggtggaaag tgaattgaaa gcatctgaat taaaaaatgt tctcgatgta     1380

ataatgaatg cttttcattg gtgttcggtt ttcatgacag aggagctggt agataaagat     1440

aataattttt atgccgagtt agaagagata tatgacgaaa tatatccggt aatttcattg     1500

tataatcttg tgcgtaatta tgtaacgcag aagccatata gtacaaaaaa aattaaattg     1560

aattttggta ttcctacact agcggatgga tggagtaaaa gtaaagaata tagtaataat     1620

gcaattattc tcatgcgtga taatttgtac tatttaggaa tatttaatgc aaaaaataag     1680

cctgacaaaa agataattga aggtaataca tcagaaaata aaggggatta taagaagatg     1740

atttataatc ttctgccagg accaaataaa atgatcccca aggtattcct ctcttcaaaa     1800

accggagtgg aaacatataa gccgtctgcc tatatattgg agggctataa acaaaacaag     1860

catattaaat cctctaagga ttttgatata acattttgtc acgatttgat tgattatttt     1920

aagaactgta tagcaataca tcctgaatgg aagaattttg gctttgattt ttctgacacc     1980

tccacatatg aagatatcag cggattttac agagaagtcg aattacaagg ttataaaatc     2040

gactggacat atatcagcga aaaggatatt gatttgttgc aggaaaaagg acagttatat     2100

ttattccaaa tatataacaa agatttttcc aagaaaagta ccggaaatga taatcttcat     2160

actatgtatt tgaagaattt gtttagtgaa gagaatttaa aggatattgt actgaaatta     2220

aacggtgagg cggaaatctt ctttagaaaa tcaagcataa agaatccaat aattcataaa     2280

aaaggctcta ttcttgttaa tagaacatat gaagcagagg aaaaagatca atttggaaat     2340

atccagatag tcagaaaaaa cataccggaa aatatatatc aggagcttta taaatatttc     2400

aatgataaaa gtgataaaga actttcggat gaagcagcta agcttaagaa tgtagtaggt     2460

catcatgagg ctgctacaaa catagtaaaa gattatagat atacatatga taaatatttt     2520

cttcatatgc ctattacaat caattttaaa gccaataaga caggctttat taatgacaga     2580

atattacaat atattgctaa agaaaaggat ttgcatgtaa taggcattga tcgtggtgaa     2640

agaaacctga tatatgtttc agtaattgat acttgtggaa atattgttga acaaaaatcg     2700

tttaacattg ttaatggata tgattatcag attaagctca agcagcagga gggggcgcga     2760

caaatcgcac gaaaagaatg gaaagaaatc ggcaaaataa aagaaattaa agaaggctat     2820

ttatctcttg taattcatga aatttcaaag atggttatta aatataatgc cataattgca     2880

atggaggatt taagctacgg atttaaaaaa ggtcgtttca aggttgagcg acaggtttac     2940

cagaagtttg agacaatgct tatcaacaaa ctcaactatc tggtatttaa agatatatcc     3000

ataacggaaa acggtggtct tctaaaggga taccagctta catatattcc agataaactg     3060

aaaaatgtgg gtcatcaatg tggctgtata ttttatgtac ctgctgccta tacatcaaaa     3120

atagatccta caaccggatt tgtaaatata ttcaaattta aagatttaac agttgatgcg     3180

aagagagaat ttataaaaaa atttgacagt atcagatatg attcagaaaa aaatctgttt     3240

tgttttacat tcgattataa taactttatt acgcaaaata ctgttatgtc aaagtcaagc     3300

tggagtgtat atacgtacgg agttaggata aaaagaagat ttgtcaatgg caggttctca     3360

aatgaatcgg atacaattga tataacaaaa gatatggaaa aaacactcga aatgacagat     3420

ataaattgga gagatggtca tgatctgagg caggatatta ttgattatga aatcgtacaa     3480

cacatatttg agatttttag attgactgta caaatgagaa acagtttaag tgaattagaa     3540

gacagggatt atgaccgttt gatttctccg gtgctcaatg aaaataatat attttatgat     3600

tcagctaaag caggagatgc gttacctaaa gacgcagatg ctaatggtgc atattgtata     3660

gctctaaaag gcttgtatga aatcaaacaa attacagaga attggaaaga agacggtaag     3720

ttttcaagag ataaacttaa aatttccaat aaggactggt ttgactttat tcaaaataaa     3780

aggtatttat aa                                                         3792


<210>  115
<211>  3792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence

<400>  115
atgaacaacg gcacaaataa ttttcagaac ttcatcggga tctcaagttt gcagaaaacg       60

ctgcgcaatg ctctgatccc cacggaaacc acgcaacagt tcatcgtcaa gaacggaata      120

attaaagaag atgagttacg tggcgagaac cgccagattc tgaaagatat catggatgac      180

tactaccgcg gattcatctc tgagactctg agttctattg atgacataga ttggactagc      240

ctgttcgaaa aaatggaaat tcagctgaaa aatggtgata ataaagatac cttaattaag      300

gaacagacag agtatcggaa agcaatccat aaaaaatttg cgaacgacga tcggtttaag      360

aacatgttta gcgccaaact gattagtgac atattacctg aatttgtcat ccacaacaat      420

aattattcgg catcagagaa agaggaaaaa acccaggtga taaaattgtt ttcgcgcttt      480

gcgactagct ttaaagatta cttcaagaac cgtgcaaatt gcttttcagc ggacgatatt      540

tcatcaagca gctgccatcg catcgtcaac gacaatgcag agatattctt ttcaaatgcg      600

ctggtctacc gccggatcgt aaaatcgctg agcaatgacg atatcaacaa aatttcgggc      660

gatatgaaag attcattaaa agaaatgagt ctggaagaaa tatattctta cgagaagtat      720

ggggaattta ttacccagga aggcattagc ttctataatg atatctgtgg gaaagtgaat      780

tcttttatga acctgtattg tcagaaaaat aaagaaaaca aaaatttata caaacttcag      840

aaacttcaca aacagattct atgcattgcg gacactagct atgaggtccc gtataaattt      900

gaaagtgacg aggaagtgta ccaatcagtt aacggcttcc ttgataacat tagcagcaaa      960

catatagtcg aaagattacg caaaatcggc gataactata acggctacaa cctggataaa     1020

atttatatcg tgtccaaatt ttacgagagc gttagccaaa aaacctaccg cgactgggaa     1080

acaattaata ccgccctcga aattcattac aataatatct tgccgggtaa cggtaaaagt     1140

aaagccgaca aagtaaaaaa agcggttaag aatgatttac agaaatccat caccgaaata     1200

aatgaactag tgtcaaacta taagctgtgc agtgacgaca acatcaaagc ggagacttat     1260

atacatgaga ttagccatat cttgaataac tttgaagcac aggaattgaa atacaatccg     1320

gaaattcacc tagttgaatc cgagctcaaa gcgagtgagc ttaaaaacgt gctggacgtg     1380

atcatgaatg cgtttcattg gtgttcggtt tttatgactg aggaacttgt tgataaagac     1440

aacaattttt atgcggaact ggaggagatt tacgatgaaa tttatccagt aattagtctg     1500

tacaacctgg ttcgtaacta cgttacccag aaaccgtaca gcacgaaaaa gattaaattg     1560

aactttggaa taccgacgtt agcagacggt tggtcaaagt ccaaagagta ttctaataac     1620

gctatcatac tgatgcgcga caatctgtat tatctgggca tctttaatgc gaagaataaa     1680

ccggacaaga agattatcga gggtaatacg tcagaaaata agggtgacta caaaaagatg     1740

atttataatt tgctcccggg tcccaacaaa atgatcccga aagttttctt gagcagcaag     1800

acgggggtgg aaacgtataa accgagcgcc tatatcctag aggggtataa acagaataaa     1860

catatcaagt cttcaaaaga ctttgatatc actttctgtc atgatctgat cgactacttc     1920

aaaaactgta ttgcaattca tcccgagtgg aaaaacttcg gttttgattt tagcgacacc     1980

agtacttatg aagacatttc cgggttttat cgtgaggtag agttacaagg ttacaagatt     2040

gattggacat acattagcga aaaagacatt gatctgctgc aggaaaaagg tcaactgtat     2100

ctgttccaga tatataacaa agatttttcg aaaaaatcaa ccgggaatga caaccttcac     2160

accatgtacc tgaaaaatct tttctcagaa gaaaatctta aggatatcgt cctgaaactt     2220

aacggcgaag cggaaatctt cttcaggaag agcagcataa agaacccaat cattcataaa     2280

aaaggctcga ttttagtcaa ccgtacctac gaagcagaag aaaaagacca gtttggcaac     2340

attcaaattg tgcgtaaaaa tattccggaa aacatttatc aggagctgta caaatacttc     2400

aacgataaaa gcgacaaaga gctgtctgat gaagcagcca aactgaagaa tgtagtggga     2460

caccacgagg cagcgacgaa tatagtcaag gactatcgct acacgtatga taaatacttc     2520

cttcatatgc ctattacgat caatttcaaa gccaataaaa cgggttttat taatgatagg     2580

atcttacagt atatcgctaa agaaaaagac ttacatgtga tcggcattga tcggggcgag     2640

cgtaacctga tctacgtgtc cgtgattgat acttgtggta atatagttga acagaaaagc     2700

tttaacattg taaacggcta cgactatcag ataaaactga aacaacagga gggcgctaga     2760

cagattgcgc ggaaagaatg gaaagaaatt ggtaaaatta aagagatcaa agagggctac     2820

ctgagcttag taatccacga gatctctaaa atggtaatca aatacaatgc aattatagcg     2880

atggaggatt tgtcttatgg ttttaaaaaa gggcgcttta aggtcgaacg gcaagtttac     2940

cagaaatttg aaaccatgct catcaataaa ctcaactatc tggtatttaa agatatttcg     3000

attaccgaga atggcggtct cctgaaaggt tatcagctga catacattcc tgataaactt     3060

aaaaacgtgg gtcatcagtg cggctgcatt ttttatgtgc ctgctgcata cacgagcaaa     3120

attgatccga ccaccggctt tgtgaatatc tttaaattta aagacctgac agtggacgca     3180

aaacgtgaat tcattaaaaa atttgactca attcgttatg acagtgaaaa aaatctgttc     3240

tgctttacat ttgactacaa taactttatt acgcaaaaca cggtcatgag caaatcatcg     3300

tggagtgtgt atacatacgg cgtgcgcatc aaacgtcgct ttgtgaacgg ccgcttctca     3360

aacgaaagtg ataccattga cataaccaaa gatatggaga aaacgttgga aatgacggac     3420

attaactggc gcgatggcca cgatcttcgt caagacatta tagattatga aattgttcag     3480

cacatattcg aaattttccg tttaacagtg caaatgcgta actccttgtc tgaactggag     3540

gaccgtgatt acgatcgtct catttcacct gtactgaacg aaaataacat tttttatgac     3600

agcgcgaaag cgggggatgc acttcctaag gatgccgatg caaatggtgc gtattgtatt     3660

gcattaaaag ggttatatga aattaaacaa attaccgaaa attggaaaga agatggtaaa     3720

ttttcgcgcg ataaactcaa aatcagcaat aaagattggt tcgactttat ccagaataag     3780

cgctatctct aa                                                         3792


<210>  116
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAD7 amino acid sequence

<400>  116

Met Asn Asn Gly Thr Asn Asn Phe Gln Asn Phe Ile Gly Ile Ser Ser 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Thr Thr Gln 
            20                  25                  30          


Gln Phe Ile Val Lys Asn Gly Ile Ile Lys Glu Asp Glu Leu Arg Gly 
        35                  40                  45              


Glu Asn Arg Gln Ile Leu Lys Asp Ile Met Asp Asp Tyr Tyr Arg Gly 
    50                  55                  60                  


Phe Ile Ser Glu Thr Leu Ser Ser Ile Asp Asp Ile Asp Trp Thr Ser 
65                  70                  75                  80  


Leu Phe Glu Lys Met Glu Ile Gln Leu Lys Asn Gly Asp Asn Lys Asp 
                85                  90                  95      


Thr Leu Ile Lys Glu Gln Thr Glu Tyr Arg Lys Ala Ile His Lys Lys 
            100                 105                 110         


Phe Ala Asn Asp Asp Arg Phe Lys Asn Met Phe Ser Ala Lys Leu Ile 
        115                 120                 125             


Ser Asp Ile Leu Pro Glu Phe Val Ile His Asn Asn Asn Tyr Ser Ala 
    130                 135                 140                 


Ser Glu Lys Glu Glu Lys Thr Gln Val Ile Lys Leu Phe Ser Arg Phe 
145                 150                 155                 160 


Ala Thr Ser Phe Lys Asp Tyr Phe Lys Asn Arg Ala Asn Cys Phe Ser 
                165                 170                 175     


Ala Asp Asp Ile Ser Ser Ser Ser Cys His Arg Ile Val Asn Asp Asn 
            180                 185                 190         


Ala Glu Ile Phe Phe Ser Asn Ala Leu Val Tyr Arg Arg Ile Val Lys 
        195                 200                 205             


Ser Leu Ser Asn Asp Asp Ile Asn Lys Ile Ser Gly Asp Met Lys Asp 
    210                 215                 220                 


Ser Leu Lys Glu Met Ser Leu Glu Glu Ile Tyr Ser Tyr Glu Lys Tyr 
225                 230                 235                 240 


Gly Glu Phe Ile Thr Gln Glu Gly Ile Ser Phe Tyr Asn Asp Ile Cys 
                245                 250                 255     


Gly Lys Val Asn Ser Phe Met Asn Leu Tyr Cys Gln Lys Asn Lys Glu 
            260                 265                 270         


Asn Lys Asn Leu Tyr Lys Leu Gln Lys Leu His Lys Gln Ile Leu Cys 
        275                 280                 285             


Ile Ala Asp Thr Ser Tyr Glu Val Pro Tyr Lys Phe Glu Ser Asp Glu 
    290                 295                 300                 


Glu Val Tyr Gln Ser Val Asn Gly Phe Leu Asp Asn Ile Ser Ser Lys 
305                 310                 315                 320 


His Ile Val Glu Arg Leu Arg Lys Ile Gly Asp Asn Tyr Asn Gly Tyr 
                325                 330                 335     


Asn Leu Asp Lys Ile Tyr Ile Val Ser Lys Phe Tyr Glu Ser Val Ser 
            340                 345                 350         


Gln Lys Thr Tyr Arg Asp Trp Glu Thr Ile Asn Thr Ala Leu Glu Ile 
        355                 360                 365             


His Tyr Asn Asn Ile Leu Pro Gly Asn Gly Lys Ser Lys Ala Asp Lys 
    370                 375                 380                 


Val Lys Lys Ala Val Lys Asn Asp Leu Gln Lys Ser Ile Thr Glu Ile 
385                 390                 395                 400 


Asn Glu Leu Val Ser Asn Tyr Lys Leu Cys Ser Asp Asp Asn Ile Lys 
                405                 410                 415     


Ala Glu Thr Tyr Ile His Glu Ile Ser His Ile Leu Asn Asn Phe Glu 
            420                 425                 430         


Ala Gln Glu Leu Lys Tyr Asn Pro Glu Ile His Leu Val Glu Ser Glu 
        435                 440                 445             


Leu Lys Ala Ser Glu Leu Lys Asn Val Leu Asp Val Ile Met Asn Ala 
    450                 455                 460                 


Phe His Trp Cys Ser Val Phe Met Thr Glu Glu Leu Val Asp Lys Asp 
465                 470                 475                 480 


Asn Asn Phe Tyr Ala Glu Leu Glu Glu Ile Tyr Asp Glu Ile Tyr Pro 
                485                 490                 495     


Val Ile Ser Leu Tyr Asn Leu Val Arg Asn Tyr Val Thr Gln Lys Pro 
            500                 505                 510         


Tyr Ser Thr Lys Lys Ile Lys Leu Asn Phe Gly Ile Pro Thr Leu Ala 
        515                 520                 525             


Asp Gly Trp Ser Lys Ser Lys Glu Tyr Ser Asn Asn Ala Ile Ile Leu 
    530                 535                 540                 


Met Arg Asp Asn Leu Tyr Tyr Leu Gly Ile Phe Asn Ala Lys Asn Lys 
545                 550                 555                 560 


Pro Asp Lys Lys Ile Ile Glu Gly Asn Thr Ser Glu Asn Lys Gly Asp 
                565                 570                 575     


Tyr Lys Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Asn Lys Met Ile 
            580                 585                 590         


Pro Lys Val Phe Leu Ser Ser Lys Thr Gly Val Glu Thr Tyr Lys Pro 
        595                 600                 605             


Ser Ala Tyr Ile Leu Glu Gly Tyr Lys Gln Asn Lys His Ile Lys Ser 
    610                 615                 620                 


Ser Lys Asp Phe Asp Ile Thr Phe Cys His Asp Leu Ile Asp Tyr Phe 
625                 630                 635                 640 


Lys Asn Cys Ile Ala Ile His Pro Glu Trp Lys Asn Phe Gly Phe Asp 
                645                 650                 655     


Phe Ser Asp Thr Ser Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Leu Gln Gly Tyr Lys Ile Asp Trp Thr Tyr Ile Ser Glu Lys 
        675                 680                 685             


Asp Ile Asp Leu Leu Gln Glu Lys Gly Gln Leu Tyr Leu Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Lys Lys Ser Thr Gly Asn Asp Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile 
                725                 730                 735     


Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg Lys Ser Ser 
            740                 745                 750         


Ile Lys Asn Pro Ile Ile His Lys Lys Gly Ser Ile Leu Val Asn Arg 
        755                 760                 765             


Thr Tyr Glu Ala Glu Glu Lys Asp Gln Phe Gly Asn Ile Gln Ile Val 
    770                 775                 780                 


Arg Lys Asn Ile Pro Glu Asn Ile Tyr Gln Glu Leu Tyr Lys Tyr Phe 
785                 790                 795                 800 


Asn Asp Lys Ser Asp Lys Glu Leu Ser Asp Glu Ala Ala Lys Leu Lys 
                805                 810                 815     


Asn Val Val Gly His His Glu Ala Ala Thr Asn Ile Val Lys Asp Tyr 
            820                 825                 830         


Arg Tyr Thr Tyr Asp Lys Tyr Phe Leu His Met Pro Ile Thr Ile Asn 
        835                 840                 845             


Phe Lys Ala Asn Lys Thr Gly Phe Ile Asn Asp Arg Ile Leu Gln Tyr 
    850                 855                 860                 


Ile Ala Lys Glu Lys Asp Leu His Val Ile Gly Ile Asp Arg Gly Glu 
865                 870                 875                 880 


Arg Asn Leu Ile Tyr Val Ser Val Ile Asp Thr Cys Gly Asn Ile Val 
                885                 890                 895     


Glu Gln Lys Ser Phe Asn Ile Val Asn Gly Tyr Asp Tyr Gln Ile Lys 
            900                 905                 910         


Leu Lys Gln Gln Glu Gly Ala Arg Gln Ile Ala Arg Lys Glu Trp Lys 
        915                 920                 925             


Glu Ile Gly Lys Ile Lys Glu Ile Lys Glu Gly Tyr Leu Ser Leu Val 
    930                 935                 940                 


Ile His Glu Ile Ser Lys Met Val Ile Lys Tyr Asn Ala Ile Ile Ala 
945                 950                 955                 960 


Met Glu Asp Leu Ser Tyr Gly Phe Lys Lys Gly Arg Phe Lys Val Glu 
                965                 970                 975     


Arg Gln Val Tyr Gln Lys Phe Glu Thr Met Leu Ile Asn Lys Leu Asn 
            980                 985                 990         


Tyr Leu Val Phe Lys Asp Ile Ser  Ile Thr Glu Asn Gly  Gly Leu Leu 
        995                 1000                 1005             


Lys Gly  Tyr Gln Leu Thr Tyr  Ile Pro Asp Lys Leu  Lys Asn Val 
    1010                 1015                 1020             


Gly His  Gln Cys Gly Cys Ile  Phe Tyr Val Pro Ala  Ala Tyr Thr 
    1025                 1030                 1035             


Ser Lys  Ile Asp Pro Thr Thr  Gly Phe Val Asn Ile  Phe Lys Phe 
    1040                 1045                 1050             


Lys Asp  Leu Thr Val Asp Ala  Lys Arg Glu Phe Ile  Lys Lys Phe 
    1055                 1060                 1065             


Asp Ser  Ile Arg Tyr Asp Ser  Glu Lys Asn Leu Phe  Cys Phe Thr 
    1070                 1075                 1080             


Phe Asp  Tyr Asn Asn Phe Ile  Thr Gln Asn Thr Val  Met Ser Lys 
    1085                 1090                 1095             


Ser Ser  Trp Ser Val Tyr Thr  Tyr Gly Val Arg Ile  Lys Arg Arg 
    1100                 1105                 1110             


Phe Val  Asn Gly Arg Phe Ser  Asn Glu Ser Asp Thr  Ile Asp Ile 
    1115                 1120                 1125             


Thr Lys  Asp Met Glu Lys Thr  Leu Glu Met Thr Asp  Ile Asn Trp 
    1130                 1135                 1140             


Arg Asp  Gly His Asp Leu Arg  Gln Asp Ile Ile Asp  Tyr Glu Ile 
    1145                 1150                 1155             


Val Gln  His Ile Phe Glu Ile  Phe Arg Leu Thr Val  Gln Met Arg 
    1160                 1165                 1170             


Asn Ser  Leu Ser Glu Leu Glu  Asp Arg Asp Tyr Asp  Arg Leu Ile 
    1175                 1180                 1185             


Ser Pro  Val Leu Asn Glu Asn  Asn Ile Phe Tyr Asp  Ser Ala Lys 
    1190                 1195                 1200             


Ala Gly  Asp Ala Leu Pro Lys  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1205                 1210                 1215             


Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Ile Lys Gln  Ile Thr Glu 
    1220                 1225                 1230             


Asn Trp  Lys Glu Asp Gly Lys  Phe Ser Arg Asp Lys  Leu Lys Ile 
    1235                 1240                 1245             


Ser Asn  Lys Asp Trp Phe Asp  Phe Ile Gln Asn Lys  Arg Tyr Leu 
    1250                 1255                 1260             


<210>  117
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scaffold sequence

<400>  117
gttaagttat atagaataat ttctactgtt gtaga                                  35


<210>  118
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scaffold sequence

<400>  118
ctctacaact gataaagaat ttctactttt gtagat                                 36


<210>  119
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scaffold sequence

<400>  119
gtctggcccc aaattttaat ttctactgtt gtagat                                 36


<210>  120
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  120
uuuaucuguc cccuccaccc caca                                              24


<210>  121
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  121
uuuacucacg ucauccagca gaga                                              24


<210>  122
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  122
uuuaccuugg ggcucugaca ggua                                              24


<210>  123
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  123
agagugauca cagcucugac uaaa                                              24


<210>  124
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  124
cucagaccug aaucugcccc caaa                                              24


<210>  125
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  125
guguaccagc ugagagacuc uaaa                                              24


<210>  126
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  126
uuucugccca acuucugcug gcau                                              24


<210>  127
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  127
uuugguccca uuggucgcgg gcuu                                              24


<210>  128
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  128
uuucccgaga ccguccuggc gcg                                               23


<210>  129
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  129
uuugucugca gggaaacaag agacc                                             25


<210>  130
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  130
uuuggagugg ccggguucua gagug                                             25


