                         SEQUENCE LISTING

<110>  City of Hope
       MORRIS, Kevin
       DAVIS, Alicia
       SCOTT, Tristan
       RAY, Roslyn
       SHEVCHENKO, Galina
       O'MEALLY, Denis
 
<120>  LIPID NANOPARTICLES AND METHODS OF USE

<130>  048440-801001WO

<150>  63/172,209
<151>  2021-04-08

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
auaccuuccc agguaacaaa ccaac                                             25


<210>  2
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  "n" is modified nucleotide with 2'O-methyl

<220>
<221>  modified_base
<222>  (26)..(28)
<223>  phosphorothioate linkage

<400>  2
anunacncnu uccncnaggu anancaaacc aac                                    33


<210>  3
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
guugguuugu uaccugggaa gguauaa                                           27


<210>  4
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  "n" is modified nucleotide with 2'O-methyl

<220>
<221>  modified_base
<222>  (1)..(2)
<223>  phosphorothioate linkage

<400>  4
guugguuugu nunanccugg gaaggnuanu naa                                    33


<210>  5
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
gucccugguu ucaacgagaa aacac                                             25


<210>  6
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  "n" is modified nucleotide with 2'O-methyl

<220>
<221>  modified_base
<222>  (26)..(28)
<223>  phosphorothioate linkage

<400>  6
gnunccncnu gguununcan ancgagaaaa ncac                                   34


<210>  7
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
guguuuucuc guugaaacca gggacaa                                           27


<210>  8
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  "n" is modified nucleotide with 2'O-methyl

<220>
<221>  modified_base
<222>  (33)..(34)
<223>  phosphorothioate linkage

<400>  8
anancnaggg nanccaaagu ugncnucuuu ugug                                   34


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
uggacugaga cugaccuuac u                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
uaaggucagu cucaguccaa c                                                 21


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
accuuauaau ucacagaaug cugua                                             25


<210>  12
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
uacagcauuc ugugaauuau aagguga                                           27


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
aacuuaugua cucauucguu u                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
acgaaugagu acauaaguuc g                                                 21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
aaccaccuug uagguuuguu a                                                 21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
acaaaccuac aaggugguuc c                                                 21


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
uguugauuca ucacagggcu cagaa                                             25


<210>  18
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
uucugagccc ugugaugaau caacagu                                           27


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
acuuauguac ucauucguuu c                                                 21


<210>  20
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
aacgaaugag uacauaaguu c                                                 21


<210>  21
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
uuugaaugug gcuaaaucug a                                                 21


<210>  22
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
agauuuagcc acauucaaag a                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
accaccuugu agguuuguua c                                                 21


<210>  24
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
aacaaaccua caaggugguu c                                                 21


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  25
uggaaccacc uuguagguuu g                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
aaccuacaag gugguuccag u                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  27
acuggaacca ccuuguaggu u                                                 21


<210>  28
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
ccuacaaggu gguuccaguu c                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  29
augaugauua uuucaauaaa a                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
uuauugaaau aaucaucauc a                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  31
acuauauguu aaaccaggug g                                                 21


<210>  32
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  32
accugguuua acauauagug a                                                 21


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  33
gcuuaguaga aguugaaaaa ggcgt                                             25


<210>  34
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  34
acgccuuuuu caacuucuac uaagcca                                           27


<210>  35
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
aagauggcac uuguggcuua guaga                                             25


<210>  36
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  36
ucuacuaagc cacaagugcc aucuuua                                           27


<210>  37
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
cccugguuuc aacgagaaaa cacac                                             25


<210>  38
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  38
guguguuuuc ucguugaaac cagggac                                           27


<210>  39
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  39
uauggguugg gauuauccua aaugt                                             25


<210>  40
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  40
acauuuagga uaaucccaac ccauaag                                           27


<210>  41
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  41
caaagaauag agcucgcacc guagc                                             25


<210>  42
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  42
gcuacggugc gagcucuauu cuuugca                                           27


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  43
uauggguugg gauuacccua aaugt                                             25


<210>  44
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  44
acauuuaggg uaaucccaac ccauaag                                           27


<210>  45
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  45
cgaacuuaug uacucauucg u                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  46
gaacuuaugu acucauucgu u                                                 21


<210>  47
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  47
ucuuugaaug uggcuaaauc u                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  48
gaaccaccuu guagguuugu u                                                 21


<210>  49
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  49
acuggaacca ccuuguaggu u                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  50
ggaaccaccu uguagguuug u                                                 21


<210>  51
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  51
guuggacuga gacugaccuu a                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  52
gaacuggaac caccuuguag g                                                 21


<210>  53
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  53
ugaugaugau uauuucaaua a                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  54
ucacuauaug uuaaaccagg u                                                 21


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  55
uugucccugg uuucaacgag a                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  56
uggcuuagua gaaguugaaa a                                                 21


<210>  57
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  57
uuauaccuuc ccagguaaca a                                                 21


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  58
uaaagauggc acuuguggcu u                                                 21


<210>  59
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  59
gucccugguu ucaacgagaa a                                                 21


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  60
cuuauggguu gggauuaucc u                                                 21


<210>  61
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  61
ugcaaagaau agagcucgca c                                                 21


<210>  62
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  62
acuguugauu caucacaggg c                                                 21


<210>  63
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  63
ucaccuuaua auucacagaa u                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  64
cuuauggguu gggauuaucc a                                                 21


<210>  65
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  65
ugcuaagaau agagcucgca c                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  66
acuguugauu caucacaggg u                                                 21


<210>  67
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  67
acuguugauu ccucacaggg u                                                 21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  68
ucaccuuaua auucacagaa c                                                 21


<210>  69
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  69
ucgccuuaua auucacagaa u                                                 21


<210>  70
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  70
cauauugcgc guauagucgc guuag                                             25


<210>  71
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  71
cuaacgcgac uauacgcgca auauggu                                           27


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  72
gacuuuccgc uggggacuuu c                                                 21


<210>  73
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  73
uggaaagucc ccagcggaaa g                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  74
cugaccuuug gauggugcuu c                                                 21


<210>  75
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  75
uggaaagucc ccagcggaaa g                                                 21


<210>  76
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  76
gacuuggugu ggaaggcgca gaaca                                             25


<210>  77
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  77
uguucugcgc cuuccacacc aagucag                                           27


<210>  78
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  78
cuuauggguu gggauuaccc u                                                 21


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  79
gagaggctaa gaagcagc                                                     18


<210>  80
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  80
acgcagttcc tcgctgtaa                                                    19


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  81
gctacagctt caccaccaca                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  82
tctccaggga ggaagaggat                                                   20


