                         SEQUENCE LISTING

<110>  DAVIDSON, Donald J.
 
<120>  ANTIVIRUS PROTEINS HAVING A KRINGLE 5 SUBUNIT

<130>  CU-75247 DCB

<160>  189   

<170>  PatentIn version 3.5

<210>  1
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(3-89 Active Zone)

<400>  1

Ser Glu Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys 
1               5                   10                  15      


Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln 
            20                  25                  30          


Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala 
        35                  40                  45              


Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly 
    50                  55                  60                  


Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp 
65                  70                  75                  80  


Val Pro Gln Cys Ala Ala Pro Lys Ser 
                85                  


<210>  2
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(3-89 Active Zone)frag-Fc

<400>  2

Ser Glu Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys 
1               5                   10                  15      


Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln 
            20                  25                  30          


Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala 
        35                  40                  45              


Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly 
    50                  55                  60                  


Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp 
65                  70                  75                  80  


Val Pro Gln Cys Ala Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                85                  90                  95      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            100                 105                 110         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        115                 120                 125             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    130                 135                 140                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
145                 150                 155                 160 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                165                 170                 175     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            180                 185                 190         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        195                 200                 205             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    210                 215                 220                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
225                 230                 235                 240 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                245                 250                 255     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            260                 265                 270         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        275                 280                 285             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    290                 295                 300                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310                 315         


<210>  3
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(57-81 Active Zone)frag -Fc

<400>  3

Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn 
1               5                   10                  15      


Pro Arg Lys Leu Tyr Asp Tyr Cys Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 


<210>  4
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(57-81 Active Zone w Ala sub Cys)frag -Fc

<400>  4

Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Ala Tyr Thr Thr Asn 
1               5                   10                  15      


Pro Arg Lys Leu Tyr Asp Tyr Ala Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 


<210>  5
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(57-81 Active Zone w Val sub Cys)frag-Fc

<400>  5

Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Val Tyr Thr Thr Asn 
1               5                   10                  15      


Pro Arg Lys Leu Tyr Asp Tyr Val Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 


<210>  6
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(57-81 Active Zone w Ile sub Cys)frag-Fc

<400>  6

Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Ile Tyr Thr Thr Asn 
1               5                   10                  15      


Pro Arg Lys Leu Tyr Asp Tyr Ile Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 


<210>  7
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(57-81 Active Zone w Leu sub Cys)frag-Fc

<400>  7

Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Leu Tyr Thr Thr Asn 
1               5                   10                  15      


Pro Arg Lys Leu Tyr Asp Tyr Leu Lys Ser Cys Asp Lys Thr His Thr 
            20                  25                  30          


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    50                  55                  60                  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
65                  70                  75                  80  


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                85                  90                  95      


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            100                 105                 110         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        115                 120                 125             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    130                 135                 140                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
145                 150                 155                 160 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                165                 170                 175     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            180                 185                 190         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    210                 215                 220                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
225                 230                 235                 240 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 


<210>  8
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(70-89 Active Zone)frag-Fc

<400>  8

Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln 
1               5                   10                  15      


Cys Ala Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
145                 150                 155                 160 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250 


<210>  9
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(70-89 Active Zone with Ala sub Cys)frag-Fc

<400>  9

Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Ala Asp Val Pro Gln 
1               5                   10                  15      


Ala Ala Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
145                 150                 155                 160 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250 


<210>  10
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(70-89 Active Zone with Val sub Cys)frag-Fc

<400>  10

Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Val Asp Val Pro Gln 
1               5                   10                  15      


Val Ala Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
145                 150                 155                 160 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250 


<210>  11
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(70-89 Active Zone with Ile sub Cys)frag-Fc

<400>  11

Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Ile Asp Val Pro Gln 
1               5                   10                  15      


Ile Ala Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
145                 150                 155                 160 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250 


<210>  12
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(70-89 Active Zone with Leu sub Cys)frag-Fc

<400>  12

Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Leu Asp Val Pro Gln 
1               5                   10                  15      


Leu Ala Ala Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            20                  25                  30          


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        35                  40                  45              


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    50                  55                  60                  


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
65                  70                  75                  80  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                85                  90                  95      


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            100                 105                 110         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        115                 120                 125             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    130                 135                 140                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
145                 150                 155                 160 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                165                 170                 175     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            180                 185                 190         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        195                 200                 205             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    210                 215                 220                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
225                 230                 235                 240 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250 


<210>  13
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(74-89 Active Zone)frag-Fc

<400>  13

Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro 
1               5                   10                  15      


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  14
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(74-89 Active Zone w Ala sub Cys)frag-Fc

<400>  14

Pro Arg Lys Leu Tyr Asp Tyr Ala Asp Val Pro Gln Ala Ala Ala Pro 
1               5                   10                  15      


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  15
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(74-89 Active Zone w Val sub Cys)frag-Fc

<400>  15

Pro Arg Lys Leu Tyr Asp Tyr Val Asp Val Pro Gln Val Ala Ala Pro 
1               5                   10                  15      


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  16
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(74-89 Active Zone w Ile sub Cys)frag-Fc

<400>  16

Pro Arg Lys Leu Tyr Asp Tyr Ile Asp Val Pro Gln Ile Ala Ala Pro 
1               5                   10                  15      


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  17
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(74-89 Active Zone w Leu sub Cys)frag-Fc

<400>  17

Pro Arg Lys Leu Tyr Asp Tyr Leu Asp Val Pro Gln Leu Ala Ala Pro 
1               5                   10                  15      


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  18
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(74-80 Active Zone)frag-Fc

<400>  18

Pro Arg Lys Leu Tyr Asp Tyr Lys Ser Cys Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235         


<210>  19
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(1-93 Active Zone)frag

<400>  19

Gly Ser Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr 
1               5                   10                  15      


Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp 
            20                  25                  30          


Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe Pro 
        35                  40                  45              


Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys 
    50                  55                  60                  


Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
65                  70                  75                  80  


Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Asp Ile 
                85                  90              


<210>  20
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(3-91 Active Zone)frag-Fc

<400>  20

Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr Arg Gly 
1               5                   10                  15      


Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp Asn Ser 
            20                  25                  30          


Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe Pro Glu Leu 
        35                  40                  45              


Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys Glu Ala 
    50                  55                  60                  


Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Cys Asp 
65                  70                  75                  80  


Ile Pro Ala Cys Asp Ser Lys Asp Ser Cys Asp Lys Thr His Thr Cys 
                85                  90                  95      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            100                 105                 110         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        115                 120                 125             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    130                 135                 140                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
145                 150                 155                 160 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                165                 170                 175     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            180                 185                 190         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        195                 200                 205             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    210                 215                 220                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
225                 230                 235                 240 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                245                 250                 255     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            260                 265                 270         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        275                 280                 285             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    290                 295                 300                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310                 315         


<210>  21
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-91 Active Zone)frag-Fc

<400>  21

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys 
            20                  25                  30          


Asp Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys 
            260         


<210>  22
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-91 Active Zone with Ala sub Cys)frag-Fc

<400>  22

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Ala Asp Ile Pro Ala Ala Asp Ser Lys 
            20                  25                  30          


Asp Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys 
            260         


<210>  23
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-91 Active Zone with Val sub Cys)frag-Fc

<400>  23

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Val Asp Ile Pro Ala Val Asp Ser Lys 
            20                  25                  30          


Asp Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys 
            260         


<210>  24
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-91 Active Zone with Ile sub Cys)frag-Fc

<400>  24

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Ile Asp Ile Pro Ala Ile Asp Ser Lys 
            20                  25                  30          


Asp Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys 
            260         


<210>  25
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-91 Active Zone with Leu sub Cys)frag-Fc

<400>  25

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Leu Asp Ile Pro Ala Leu Asp Ser Lys 
            20                  25                  30          


Asp Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys 
            260         


<210>  26
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone)frag-Fc

<400>  26

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  27
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Ala sub Cys)frag-Fc

<400>  27

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  28
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Val sub Cys)frag-Fc

<400>  28

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  29
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Ile sub Cys)frag-Fc

<400>  29

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  30
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Leu sub Cys)frag-Fc

<400>  30

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  31
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(70-80 Active Zone)frag-Fc

<400>  31

Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His 
1               5                   10                  15      


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        35                  40                  45              


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    50                  55                  60                  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
65                  70                  75                  80  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                85                  90                  95      


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            100                 105                 110         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        115                 120                 125             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 


<210>  32
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(73-80 Active Zone)frag-Fc

<400>  32

Asp Glu Asn Phe Lys Ser Asp Leu Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235     


<210>  33
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(1-85 Active Zone)frag

<400>  33

Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly 
1               5                   10                  15      


Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu 
            20                  25                  30          


Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu Leu 
        35                  40                  45              


Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly 
    50                  55                  60                  


Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp 
65                  70                  75                  80  


Val Pro Ser Cys Ser 
                85  


<210>  34
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(1-85 Active Zone)frag-Fc

<400>  34

Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly 
1               5                   10                  15      


Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu 
            20                  25                  30          


Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu Leu 
        35                  40                  45              


Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly 
    50                  55                  60                  


Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp 
65                  70                  75                  80  


Val Pro Ser Cys Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                85                  90                  95      


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            100                 105                 110         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        115                 120                 125             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    130                 135                 140                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
145                 150                 155                 160 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                165                 170                 175     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            180                 185                 190         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        195                 200                 205             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    210                 215                 220                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
225                 230                 235                 240 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                245                 250                 255     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            260                 265                 270         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        275                 280                 285             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    290                 295                 300                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310                 315     


<210>  35
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-85 Active Zone)frag-Fc

<400>  35

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys 
            260     


<210>  36
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-85 Active Zone w Ala sub Cys)frag-Fc

<400>  36

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Ala Asp Val Pro Ser Ala Ser Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys 
            260     


<210>  37
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-85 Active Zone w Val sub Cys)frag-Fc

<400>  37

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Val Asp Val Pro Ser Val Ser Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys 
            260     


<210>  38
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-85 Active Zone w Ile sub Cys)frag-Fc

<400>  38

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Ile Asp Val Pro Ser Ile Ser Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys 
            260     


<210>  39
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-85 Active Zone w Leu sub Cys)frag-Fc

<400>  39

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Leu Asp Val Pro Ser Leu Ser Pro Lys 
            20                  25                  30          


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        35                  40                  45              


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    50                  55                  60                  


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
65                  70                  75                  80  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                85                  90                  95      


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            100                 105                 110         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        115                 120                 125             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    130                 135                 140                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
145                 150                 155                 160 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                165                 170                 175     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            180                 185                 190         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        195                 200                 205             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    210                 215                 220                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
225                 230                 235                 240 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                245                 250                 255     


Leu Ser Pro Gly Lys 
            260     


<210>  40
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-85 Active Zone)frag-Fc

<400>  40

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp Val Pro Ser 
1               5                   10                  15      


Cys Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 


<210>  41
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-85  Active Zone w Ala sub Cys)frag-Fc

<400>  41

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Ala Asp Val Pro Ser 
1               5                   10                  15      


Ala Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 


<210>  42
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-85  Active Zone w Val sub Cys)frag-Fc

<400>  42

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Val Asp Val Pro Ser 
1               5                   10                  15      


Val Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 


<210>  43
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-85 Active Zone w Ile sub Cys)frag-Fc

<400>  43

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Ile Asp Val Pro Ser 
1               5                   10                  15      


Ile Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 


<210>  44
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-85 Active Zone w Leu sub Cys)frag-Fc

<400>  44

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Leu Asp Val Pro Ser 
1               5                   10                  15      


Leu Ser Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        35                  40                  45              


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    50                  55                  60                  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
65                  70                  75                  80  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                85                  90                  95      


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            100                 105                 110         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        115                 120                 125             


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    130                 135                 140                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
145                 150                 155                 160 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                165                 170                 175     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            180                 185                 190         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        195                 200                 205             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    210                 215                 220                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
225                 230                 235                 240 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 


<210>  45
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-79 Active Zone w Lys sub Cys)frag-Fc

<400>  45

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Lys Ser Cys Asp Lys 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys 
    


<210>  46
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-81 Active Zone w Ala sub Cys and w Lys 
       sub Cys)frag

<400>  46

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-81 Active Zone w Val sub Cys and w Lys 
       sub Cys)frag

<400>  47

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  48
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-81 Active Zone w Ile sub Cys and w Lys 
       sub Cys)frag

<400>  48

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  49
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-81 Active Zone w Leu sub Cys and w Lys 
       sub Cys)frag

<400>  49

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  50
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Ala sub Cys)frag

<400>  50

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  51
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Val sub Cys)frag

<400>  51

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  52
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Ile sub Cys)frag

<400>  52

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  53
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-80 Active Zone w Leu sub Cys)frag

<400>  53

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-69 Active Zone w Lys sub Cys)frag

<400>  54

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Lys 
1               5                   10          


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(58-68 Active Zone)frag

<400>  55

Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp 
1               5                   10      


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(70-81 Active Zone w Lys sub Cys)frag

<400>  56

Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Lys 
1               5                   10          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(70-80 Active Zone)frag

<400>  57

Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10      


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(71-80 Active Zone)frag

<400>  58

Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(72-80 Active Zone)frag

<400>  59

Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(73-80 Active Zone)frag

<400>  60

Asp Glu Asn Phe Lys Ser Asp Leu 
1               5               


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr1(73-79 Active Zone)frag

<400>  61

Asp Glu Asn Phe Lys Ser Asp 
1               5           


<210>  62
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(6-84 Active Zone)frag

<400>  62

Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr 
1               5                   10                  15      


Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu Gln His Pro His Ser 
            20                  25                  30          


His His Leu Ser Ser Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala 
        35                  40                  45              


Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr 
    50                  55                  60                  


Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp Val Pro Ser Cys 
65                  70                  75                  


<210>  63
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-79 Active Zone w Ala sub Cys and Lys sub
       Cys)frag

<400>  63

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  64
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-79 Active Zone w Val sub Cys and Lys sub
       Cys)frag

<400>  64

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  65
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-79 Active Zone w Ile sub Cys and Lys sub
       Cys)

<400>  65

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-79 Active Zone w Leu sub Cys and Lys sub
       Cys)frag

<400>  66

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  67
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-78 Active Zone w Ala sub Cys)frag

<400>  67

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  68
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-78 Active Zone w Val sub Cys)frag

<400>  68

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-78 Active Zone w Ile sub Cys)frag

<400>  69

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  70
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-78 Active Zone w Leu sub Cys)frag

<400>  70

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-67 Active Zone with Lys sub Cys)frag

<400>  71

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Lys 
1               5                   10          


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(56-66 Active Zone)frag

<400>  72

Arg Asn Pro Gly Gly Gln Met Glu Gly Pro Trp 
1               5                   10      


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-79 Active Zone w Lys sub Cys)frag

<400>  73

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Lys 
1               5                   10          


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(68-78 Active Zone)frag

<400>  74

Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10      


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(69-78 Active Zone)frag

<400>  75

Thr Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10  


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(70-78 Active Zone)frag

<400>  76

Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(70-77 Active Zone)frag

<400>  77

Gln Asn Lys Asn Val Arg Met Glu 
1               5               


<210>  78
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ala sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  78

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  79
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Val sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  79

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  80
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ile sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  80

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  81
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Leu sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  81

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  82
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ala sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  82

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  83
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Val sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  83

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  84
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ile sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  84

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  85
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Leu sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  85

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  86
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ala sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  86

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  87
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Val sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  87

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  88
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ile sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  88

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  89
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Leu sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  89

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu Lys 
            20                  


<210>  90
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ala sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  90

Xaa Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp Glu 
1               5                   10                  15      


Asn Phe Lys Ser Asp Leu Xaa 
            20              


<210>  91
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Val sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  91

Xaa Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp Glu 
1               5                   10                  15      


Asn Phe Lys Ser Asp Leu Xaa 
            20              


<210>  92
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Ile sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  92

Xaa Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp Glu 
1               5                   10                  15      


Asn Phe Lys Ser Asp Leu Xaa 
            20              


<210>  93
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-81 Active Zone w Leu sub Cys and w 
       Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  93

Xaa Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp Glu 
1               5                   10                  15      


Asn Phe Lys Ser Asp Leu Xaa 
            20              


<210>  94
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Ala sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  94

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  95
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Val sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  95

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  96
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Ile sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  96

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  97
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Leu sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  97

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  98
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Ala sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  98

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  99
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Val sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  99

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  100
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Ile sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  100

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  101
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone w Leu sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  101

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  102
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone)


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  102

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ala Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  103
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  103

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Val Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  104
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  104

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Ile Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  105
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  105

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Leu Phe Thr Leu Asp 
1               5                   10                  15      


Glu Asn Phe Lys Ser Asp Leu 
            20              


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-69 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  106

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Lys 
1               5                   10          


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-69 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  107

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Lys 
1               5                   10          


<210>  108
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-69 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  108

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Lys 
1               5                   10          


<210>  109
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-69 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  109

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Xaa 
1               5                   10          


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-68 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  110

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-68 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  111

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp 
1               5                   10      


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(58-68 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  112

Xaa Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp 
1               5                   10      


<210>  113
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-81 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to NAc

<400>  113

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Lys 
1               5                   10          


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-81 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA

<400>  114

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Lys 
1               5                   10          


<210>  115
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-81 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA-AEEA

<400>  115

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Lys 
1               5                   10          


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-81 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to NAc

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  116

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Xaa 
1               5                   10          


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to NAc

<400>  117

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10      


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA

<400>  118

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10      


<210>  119
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(70-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA-AEEA

<400>  119

Xaa Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10      


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(71-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr linked to NAc

<400>  120

Xaa Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(71-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr linked to MPA

<400>  121

Xaa Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(71-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr linked to MPA-AEEA

<400>  122

Xaa Leu Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   10  


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(72-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Leu linked to NAc

<400>  123

Xaa Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(72-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Leu linked to MPA

<400>  124

Xaa Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(72-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Leu linked to MPA-AEEA

<400>  125

Xaa Asp Glu Asn Phe Lys Ser Asp Leu 
1               5                   


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(73-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp linked to NAc

<400>  126

Xaa Glu Asn Phe Lys Ser Asp Leu 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(73-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp linked to MPA

<400>  127

Xaa Glu Asn Phe Lys Ser Asp Leu 
1               5               


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(73-80 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp linked to MPA-AEEA

<400>  128

Xaa Glu Asn Phe Lys Ser Asp Leu 
1               5               


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(73-79 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp linked to NAc

<400>  129

Xaa Glu Asn Phe Lys Ser Asp 
1               5           


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(73-79 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp linked to MPA

<400>  130

Xaa Glu Asn Phe Lys Ser Asp 
1               5           


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(73-79 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Asp linked to MPA-AEEA

<400>  131

Xaa Glu Asn Phe Lys Ser Asp 
1               5           


<210>  132
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(1-85 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly is linked to NAc

<400>  132

Xaa Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly 
1               5                   10                  15      


Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu 
            20                  25                  30          


Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu Leu 
        35                  40                  45              


Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly 
    50                  55                  60                  


Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp 
65                  70                  75                  80  


Val Pro Ser Cys Ser 
                85  


<210>  133
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(1-85 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly is linked to MPA

<400>  133

Xaa Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly 
1               5                   10                  15      


Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu 
            20                  25                  30          


Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu Leu 
        35                  40                  45              


Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly 
    50                  55                  60                  


Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp 
65                  70                  75                  80  


Val Pro Ser Cys Ser 
                85  


<210>  134
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Kr2(1-85 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly is linked to MPA-AEEA

<400>  134

Xaa Arg Tyr His Gln Cys Tyr Asn Gly Ser Gly Met Asp Tyr Arg Gly 
1               5                   10                  15      


Thr Ala Ser Thr Thr Lys Ser Gly His Gln Cys Gln Pro Trp Ala Leu 
            20                  25                  30          


Gln His Pro His Ser His His Leu Ser Ser Thr Asp Phe Pro Glu Leu 
        35                  40                  45              


Gly Gly Gly His Ala Tyr Cys Arg Asn Pro Gly Gly Gln Met Glu Gly 
    50                  55                  60                  


Pro Trp Cys Phe Thr Gln Asn Lys Asn Val Arg Met Glu Leu Cys Asp 
65                  70                  75                  80  


Val Pro Ser Cys Ser 
                85  


<210>  135
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ala sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  135

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  136
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Val sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  136

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  137
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ile sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  137

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  138
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Leu sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  138

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  139
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ala sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  139

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  140
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Val sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  140

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  141
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ile sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  141

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  142
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Leu sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  142

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  143
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ala sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  143

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  144
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Val sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  144

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  145
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ile sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  145

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  146
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Leu sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  146

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Lys 
            20                  


<210>  147
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ala sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  147

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Xaa 
            20                  


<210>  148
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Val sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  148

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Xaa 
            20                  


<210>  149
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Ile sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  149

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Xaa 
            20                  


<210>  150
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-79 Active Zone w Leu sub Cys and Lys
       sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  150

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu Xaa 
            20                  


<210>  151
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Ala sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  151

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  152
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Val sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  152

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  153
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Ile sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  153

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  154
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Leu sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  154

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  155
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Ala sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  155

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  156
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Val sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  156

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  157
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Ile sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  157

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  158
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Leu sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  158

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  159
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Ala sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  159

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ala Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  160
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Val sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  160

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Val Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  161
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Ile sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  161

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Ile Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  162
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-78 Active Zone w Leu sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  162

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Leu Phe Thr Gln Asn 
1               5                   10                  15      


Lys Asn Val Arg Met Glu Leu 
            20              


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-67 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  163

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Lys 
1               5                   10          


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-67 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  164

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Lys 
1               5                   10          


<210>  165
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-67 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  165

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Lys 
1               5                   10          


<210>  166
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-67 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  166

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp Xaa 
1               5                   10          


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-66 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to NAc

<400>  167

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp 
1               5                   10      


<210>  168
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-66 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA

<400>  168

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp 
1               5                   10      


<210>  169
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(56-66 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Arg linked to MPA-AEEA

<400>  169

Xaa Asn Pro Gly Gly Gln Met Glu Gly Pro Trp 
1               5                   10      


<210>  170
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-79 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to NAc

<400>  170

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu Lys 
1               5                   10          


<210>  171
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-79 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA

<400>  171

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu Lys 
1               5                   10          


<210>  172
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-79 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA-AEEA

<400>  172

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu Lys 
1               5                   10          


<210>  173
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-79 Active Zone w Lys sub Cys)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Phe is NAc-Phe

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is Lys linked to N-epsilon-MPA

<400>  173

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu Xaa 
1               5                   10          


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to NAc

<400>  174

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10      


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA

<400>  175

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10      


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(68-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Phe linked to MPA-AEEA

<400>  176

Xaa Thr Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10      


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(69-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr linked to NAc

<400>  177

Xaa Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10  


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(69-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr linked to MPA

<400>  178

Xaa Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10  


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(69-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Thr linked to MPA-AEEA

<400>  179

Xaa Gln Asn Lys Asn Val Arg Met Glu Leu 
1               5                   10  


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(70-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gln linked to NAc

<400>  180

Xaa Asn Lys Asn Val Arg Met Glu Leu 
1               5                   


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(70-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gln linked to MPA

<400>  181

Xaa Asn Lys Asn Val Arg Met Glu Leu 
1               5                   


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(70-78 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gln linked to MPA-AEEA

<400>  182

Xaa Asn Lys Asn Val Arg Met Glu Leu 
1               5                   


<210>  183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(70-77 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gln linked to NAc

<400>  183

Xaa Asn Lys Asn Val Arg Met Glu 
1               5               


<210>  184
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(70-77 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gln linked to MPA

<400>  184

Xaa Asn Lys Asn Val Arg Met Glu 
1               5               


<210>  185
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr2(70-77 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gln linked to MPA-AEEA

<400>  185

Xaa Asn Lys Asn Val Arg Met Glu 
1               5               


<210>  186
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(1-93 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly linked to NAc

<400>  186

Xaa Ser Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr 
1               5                   10                  15      


Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp 
            20                  25                  30          


Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe Pro 
        35                  40                  45              


Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys 
    50                  55                  60                  


Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
65                  70                  75                  80  


Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Asp Ile 
                85                  90              


<210>  187
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(1-93 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly linked to MPA

<400>  187

Xaa Ser Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr 
1               5                   10                  15      


Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp 
            20                  25                  30          


Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe Pro 
        35                  40                  45              


Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys 
    50                  55                  60                  


Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
65                  70                  75                  80  


Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Asp Ile 
                85                  90              


<210>  188
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Mod-Kr1(1-93 Active Zone)frag


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Gly linked to MPA-AEEA

<400>  188

Xaa Ser Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr 
1               5                   10                  15      


Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp 
            20                  25                  30          


Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe Pro 
        35                  40                  45              


Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys 
    50                  55                  60                  


Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu 
65                  70                  75                  80  


Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Asp Ile 
                85                  90              


<210>  189
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide K5(1-91 Active Zone)frag

<400>  189

Gly Ser Ser Glu Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg 
1               5                   10                  15      


Gly Lys Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala 
            20                  25                  30          


Ala Gln Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro 
        35                  40                  45              


Arg Ala Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val 
    50                  55                  60                  


Gly Gly Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr 
65                  70                  75                  80  


Cys Asp Val Pro Gln Cys Ala Ala Pro Asp Ile 
                85                  90      


