                         SEQUENCE LISTING

<110>  VAXTHERA SAS
       OSORIO, JORGE E.
 
<120>  CORONAVIRUS VACCINE COMPRISING A MOSAIC PROTEIN

<130>  4997.002PC03

<150>  US 63/301,417
<151>  2022-01-20

<150>  US 63/263,131
<151>  2021-10-27

<150>  US 63/172,495
<151>  2021-04-08

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-1 (amino acid sequence)

<400>  1

Met Phe Leu Ile Leu Leu Ile Ser Leu Pro Thr Ala Phe Ala Val Ile 
1               5                   10                  15      


Gly Asp Leu Asn Cys Pro Leu Asp Pro Arg Leu Lys Gly Ser Phe Asn 
            20                  25                  30          


Asn Arg Asp Thr Gly Pro Pro Ser Ile Ser Thr Asp Thr Val Asp Val 
        35                  40                  45              


Thr Asn Gly Leu Gly Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn 
    50                  55                  60                  


Thr Thr Leu Phe Leu Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Asn Met Ala Leu Lys Gly Thr Asp Lys Leu Ser Thr Leu Trp Phe 
                85                  90                  95      


Lys Pro Pro Phe Leu Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val 
            100                 105                 110         


Lys Asn Thr Lys Val Phe Lys Asp Gly Val Met Tyr Ser Glu Phe Pro 
        115                 120                 125             


Ala Ile Thr Ile Gly Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val 
    130                 135                 140                 


Val Gln Pro Arg Thr Ile Asn Ser Thr Gln Asp Gly Val Asn Lys Leu 
145                 150                 155                 160 


Gln Gly Leu Leu Glu Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr 
                165                 170                 175     


Pro His Thr Ile Cys His Pro Lys Leu Gly Asn His Phe Lys Glu Leu 
            180                 185                 190         


Trp His Leu Asp Thr Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe 
        195                 200                 205             


Thr Tyr Asp Val Asn Ala Thr Tyr Leu Tyr Phe His Phe Tyr Gln Glu 
    210                 215                 220                 


Gly Gly Thr Phe Tyr Ala Tyr Phe Thr Asp Thr Gly Phe Val Thr Lys 
225                 230                 235                 240 


Phe Leu Phe Asn Val Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val 
                245                 250                 255     


Met Pro Leu Thr Cys Ile Ser Arg Leu Asp Ile Gly Phe Thr Leu Glu 
            260                 265                 270         


Tyr Trp Val Thr Pro Leu Thr Pro Arg Gln Tyr Leu Leu Ala Phe Asn 
        275                 280                 285             


Gln Asp Gly Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp Phe Met 
    290                 295                 300                 


Ser Glu Ile Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr Gly Val 
305                 310                 315                 320 


Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Ile Ala Asp Val Tyr Arg 
                325                 330                 335     


Arg Lys Pro Asp Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu Asn Asp 
            340                 345                 350         


Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Ser Asn 
        355                 360                 365             


Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala Asp Ser 
    370                 375                 380                 


Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met Cys Phe 
385                 390                 395                 400 


Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Arg Arg Lys Val 
                405                 410                 415     


Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Ser Asn Tyr Arg 
            420                 425                 430         


Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu Pro Ala 
        435                 440                 445             


Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn Lys Arg 
    450                 455                 460                 


Phe Gly Phe Ile Glu Asp Ser Val Phe Val Pro Gln Pro Thr Gly Val 
465                 470                 475                 480 


Phe Thr Asn His Ser Val Val Tyr Ala Gln His Cys Phe Lys Ala Pro 
                485                 490                 495     


Lys Asn Phe Cys Pro Cys Ser Ser Cys Pro Gly Lys Asn Asn Gly Ile 
            500                 505                 510         


Gly Thr Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu Cys 
        515                 520                 525             


Thr Leu Asp Pro Ile Thr Phe Lys Ala Pro Asp Thr Tyr Lys Cys Pro 
    530                 535                 540                 


Gln Thr Lys Ser Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala 
545                 550                 555                 560 


Val Lys Ser Asp Tyr Cys Gly Asn Asn Ser Cys Thr Cys Gln Pro Gln 
                565                 570                 575     


Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys 
            580                 585                 590         


Asn Ile Phe Ala Asn Phe Ile Leu His Asp Val Asn Asn Gly Leu Thr 
        595                 600                 605             


Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr Glu Ile Glu Leu Gly Val 
    610                 615                 620                 


Cys Val Asn Tyr Asp Leu Tyr Gly Ile Ser Gly Gln Gly Ile Phe Val 
625                 630                 635                 640 


Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp 
                645                 650                 655     


Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr 
            660                 665                 670         


Phe Met Ile His Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Tyr His 
        675                 680                 685             


Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn 
    690                 695                 700                 


Tyr Val Phe Asn Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr 
705                 710                 715                 720 


Ser Phe Asp Ser Tyr Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr 
                725                 730                 735     


Ala Ile Ser Val Gln Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys 
            740                 745                 750         


Val Asp Tyr Ser Lys Asn Arg Arg Ser Arg Gly Ala Ile Thr Thr Gly 
        755                 760                 765             


Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp 
    770                 775                 780                 


Ser Leu Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu 
785                 790                 795                 800 


Phe Thr Ile Gly Asn Met Glu Glu Phe Ile Gln Thr Ser Ser Pro Lys 
                805                 810                 815     


Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys 
            820                 825                 830         


Lys Leu Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala 
        835                 840                 845             


Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val 
    850                 855                 860                 


Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp 
865                 870                 875                 880 


Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly 
                885                 890                 895     


Cys Leu Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu 
            900                 905                 910         


Asp Leu Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu 
        915                 920                 925             


Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys 
    930                 935                 940                 


Val Gln Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu 
945                 950                 955                 960 


Asn Gln Ile Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe 
                965                 970                 975     


Pro Pro Trp Thr Ala Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln 
            980                 985                 990         


Tyr Arg Ile Asn Gly Leu Gly Val  Thr Met Asp Val Leu  Ser Gln Asn 
        995                 1000                 1005             


Gln Lys  Leu Ile Ala Asn Ala  Phe Asn Asn Ala Leu  His Ala Ile 
    1010                 1015                 1020             


Gln Gln  Gly Phe Asp Ala Thr  Asn Ser Ala Leu Val  Lys Ile Gln 
    1025                 1030                 1035             


Ala Val  Val Asn Ala Asn Ala  Glu Ala Leu Asn Asn  Leu Leu Gln 
    1040                 1045                 1050             


Gln Leu  Ser Asn Arg Phe Gly  Ala Ile Ser Ala Ser  Leu Gln Glu 
    1055                 1060                 1065             


Ile Leu  Ser Arg Leu Asp Ala  Leu Glu Ala Glu Ala  Gln Ile Asp 
    1070                 1075                 1080             


Arg Leu  Ile Asn Gly Arg Leu  Thr Ala Leu Asn Ala  Tyr Val Ser 
    1085                 1090                 1095             


Gln Gln  Leu Ser Asp Ser Thr  Leu Val Lys Phe Ser  Ala Ala Gln 
    1100                 1105                 1110             


Ala Met  Glu Lys Val Asn Glu  Cys Val Lys Ser Gln  Ser Ser Arg 
    1115                 1120                 1125             


Ile Asn  Phe Cys Gly Asn Gly  Asn His Ile Ile Ser  Leu Val Gln 
    1130                 1135                 1140             


Asn Ala  Pro Tyr Gly Leu Tyr  Phe Ile His Phe Asn  Tyr Val Pro 
    1145                 1150                 1155             


Thr Lys  Tyr Val Thr Ala Lys  Val Ser Pro Gly Leu  Cys Ile Ala 
    1160                 1165                 1170             


Gly Asn  Arg Gly Ile Ala Pro  Lys Ser Gly Tyr Phe  Val Asn Val 
    1175                 1180                 1185             


Asn Asn  Thr Trp Met Tyr Thr  Gly Ser Gly Tyr Tyr  Tyr Pro Glu 
    1190                 1195                 1200             


Pro Ile  Thr Glu Asn Asn Val  Val Val Met Ser Thr  Cys Ala Val 
    1205                 1210                 1215             


Asn Tyr  Thr Lys Ala Pro Tyr  Val Met Leu Asn Thr  Ser Ile Pro 
    1220                 1225                 1230             


Asn Leu  Pro Asp Phe Lys Glu  Glu Leu Asp Gln Trp  Phe Lys Asn 
    1235                 1240                 1245             


Gln Thr  Ser Val Ala Pro Asp  Leu Ser Leu Asp Tyr  Ile Asn Val 
    1250                 1255                 1260             


Thr Phe  Leu Asp Leu Gln Val  Glu Met Asn Arg Leu  Gln Glu Ala 
    1265                 1270                 1275             


Ile Lys  Val Leu Asn His Ser  Tyr Ile Asn Leu Lys  Asp Ile Gly 
    1280                 1285                 1290             


Thr Tyr  Glu Tyr Tyr Val Lys  Trp Pro Trp Tyr Val  Trp Leu Leu 
    1295                 1300                 1305             


Ile Cys  Leu Ala Gly Val Ala  Met Leu Val Leu Leu  Phe Phe Ile 
    1310                 1315                 1320             


Cys Cys  Cys Thr Gly Cys Gly  Thr Ser Cys Phe Lys  Lys Cys Gly 
    1325                 1330                 1335             


Gly Cys  Cys Asp Asp Tyr Thr  Gly Tyr Gln Glu Leu  Val Ile Lys 
    1340                 1345                 1350             


Thr Ser  His Asp Asp 
    1355             


<210>  2
<211>  4077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-1 (nucleic acid sequence)

<400>  2
atgtttttaa ttttattaat ttctttacca acagcatttg cagtaattgg agatttaaat       60

tgtccattag atccaagatt aaaaggatct tttaataata gagatacagg accaccatct      120

atttctacag atacagtaga tgtaacaaat ggattaggaa catattatgt attagataga      180

gtatatttaa atacaacatt atttttaaat ggatattatc caacatctgg atctacatat      240

agaaatatgg cattaaaagg aacagataaa ttatctacat tatggtttaa accaccattc      300

ttatctgatt ttattaatgg aatttttgca aaagtaaaaa atacaaaagt atttaaagat      360

ggagtaatgt attctgaatt tccagcaatt acaattggat ctacatttgt aaatacatct      420

tattctgtag tagtacaacc aagaacaatt aattctacac aagatggagt aaataaatta      480

caaggattat tagaagtatc tgtatgtcaa tataatatgt gtgaatatcc acatacaatt      540

tgtcatccaa aattaggaaa tcattttaaa gaattatggc atttagatac aggagtagta      600

tcttgtttat ataaaagaaa ttttacatat gatgtaaatg caacatattt atattttcat      660

ttctatcaag aaggaggaac attttatgca tattttacag atacaggatt tgtaacaaaa      720

ttcttattta atgtatattt aggaatggca ttatctcatt attatgtaat gccattaaca      780

tgtatttcta gattagatat tggatttaca ttagaatatt gggtaacacc attaacacca      840

agacaatatt tattagcatt taatcaagat ggaattattt ttaatgcagt agattgtatg      900

tctgatttta tgtctgaaat taaatgtaaa acacaatcta ttgcaccacc aacaggagta      960

tatgaattaa atggatatac agtacaacca attgcagatg tatatagaag aaaaccagat     1020

ttaccaaatt gtaatattga agcatggtta aatgataaat ctgtaccatc tccattaaat     1080

tgggaaagaa aaacattttc taattgtaat tttaatatgt cttctttaat gtcttttatt     1140

caagcagatt cttttacatg taataatatt gatgcagcaa aaatttatgg aatgtgtttc     1200

tcttctatta caattgataa atttgcaatt ccaaatagaa gaaaagtaga tttacaatta     1260

ggaaatttag gatatttaca atcttctaat tatagaattg atacaacagc aacatcttgt     1320

caattatatt ataatttacc agcagcaaat gtatctgtat ctagatttaa tccatctaca     1380

tggaataaaa gatttggatt tattgaagat tctgtatttg taccacaacc aacaggagta     1440

tttacaaatc attctgtagt atatgcacaa cattgtttta aagcaccaaa aaatttctgt     1500

ccatgttctt cttgtccagg aaaaaataat ggaattggaa catgtccagc aggaacaaat     1560

tatttaacat gtgataattt atgtacatta gatccaatta catttaaagc accagataca     1620

tataaatgtc cacaaacaaa atctttagta ggaattggag aacattgttc tggattagca     1680

gtaaaatctg attattgtgg aaataattct tgtacatgtc aaccacaagc atttttagga     1740

tggtctgcag attcttgttt acaaggagat aaatgtaata tttttgcaaa ttttatttta     1800

catgatgtaa ataatggatt aacatgttct acagatttac aaaaagcaaa tacagaaatt     1860

gaattaggag tatgtgtaaa ttatgattta tatggaattt ctggacaagg aattttcgta     1920

gaagtaaatg caacatatta taattcttgg caaaatttat tatatgattc taatggaaat     1980

ttatatggat ttagagatta tattacaaat agaacattta tgattcattc ttgttattct     2040

ggaagagtat ctgcagcata tcatgcaaat tcttctgaac cagcattatt atttagaaat     2100

attaaatgta attatgtatt taataattct ttaacaagac aattacaacc aattaattat     2160

tcttttgatt cttatttagg atgtgtagta aatgcatata attctacagc aatttctgta     2220

caaacatgtg atttaacagt aggatctgga tattgtgtag attattctaa aaatagaaga     2280

tctagaggag caattacaac aggatataga tttacaaatt ttgaaccatt tacagtaaat     2340

tctgtaaatg attctttaga accagtagga ggattatatg aaattcaaat tccatctgaa     2400

tttacaattg gaaatatgga agaatttatt caaacatctt ctccaaaagt aacaattgat     2460

tgtgcagcat ttgtatgtgg agattatgca gcatgtaaat tacaattagt agaatatgga     2520

tctttctgtg ataatattaa tgcaatttta acagaagtaa atgaattatt agatacaaca     2580

caattacaag tagcaaattc tttaatgaat ggagtaacat tatctacaaa attaaaagat     2640

ggagtaaatt ttaatgtaga tgatattaat ttctctccag tattaggatg tttaggatct     2700

gaatgttcta aagcatcttc tagatctgca attgaagatt tattatttga taaagtaaaa     2760

ttatctgatg taggatttgt agaagcatat aataattgta caggaggagc agaaattaga     2820

gatttaattt gtgtacaatc ttataaagga attaaagtat taccaccatt attatctgaa     2880

aatcaaattt ctggatatac attagcagca acatctgcat ctttatttcc accatggaca     2940

gcagcagcag gagtaccatt ttatttaaat gtacaatata gaattaatgg attaggagta     3000

acaatggatg tattatctca aaatcaaaaa ttaattgcaa atgcatttaa taatgcatta     3060

catgcaattc aacaaggatt tgatgcaaca aattctgcat tagtaaaaat tcaagcagta     3120

gtaaatgcaa atgcagaagc attaaataat ttattacaac aattatctaa tagatttgga     3180

gcaatttctg catctttaca agaaatttta tctagattag atgcattaga agcagaagca     3240

caaattgata gattaattaa tggaagatta acagcattaa atgcatatgt atctcaacaa     3300

ttatctgatt ctacattagt aaaattttct gcagcacaag caatggaaaa agtaaatgaa     3360

tgtgtaaaat ctcaatcttc tagaattaat ttctgtggaa atggaaatca tattatttct     3420

ttagtacaaa atgcaccata tggattatat tttattcatt ttaattatgt accaacaaaa     3480

tatgtaacag caaaagtatc tccaggatta tgtattgcag gaaatagagg aattgcacca     3540

aaatctggat attttgtaaa tgtaaataat acatggatgt atacaggatc tggatattat     3600

tatccagaac caattacaga aaataatgta gtagtaatgt ctacatgtgc agtaaattat     3660

acaaaagcac catatgtaat gttaaataca tctattccaa atttaccaga ttttaaagaa     3720

gaattagatc aatggtttaa aaatcaaaca tctgtagcac cagatttatc tttagattat     3780

attaatgtaa catttttaga tttacaagta gaaatgaata gattacaaga agcaattaaa     3840

gtattaaatc attcttatat taatttaaaa gatattggaa catatgaata ttatgtaaaa     3900

tggccatggt atgtatggtt attaatttgt ttagcaggag tagcaatgtt agtattatta     3960

tttttcattt gttgttgtac aggatgtgga acatcttgtt ttaaaaaatg tggaggatgt     4020

tgtgatgatt atacaggata tcaagaatta gtaattaaaa catctcatga tgattaa        4077


<210>  3
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-2 (amino acid sequence)

<400>  3

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Arg  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  4
<211>  4062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-2 (nucleic acid sequence)

<400>  4
atgattcatt ctgttttctt attaatgttc ttattaacac caacagaatc ttatgtagat       60

gtaggaccag attctgtaaa atctgcatgt attgaagtag atattcaaca aacatttttt      120

gataaaacat ggccaagacc aattgatgta tctaaagcag atggaattat ttatccacaa      180

ggaagaacat attctaatat tacaattaca tatcaaggat tatttccata tcaaggagat      240

catggagata tgtatgtata ttctgcagga catgcaacag gaacaacacc acaaaaatta      300

tttgtagcaa attattctca agatgtaaaa caatttgcaa atggatttgt agtaagaatt      360

ggagcagcag caaattctac aggaacagta attatttctc catctacatc tgcaacaatt      420

agaaaaattt atccagcatt tatgttagga tcttctgtag gaaatttctc tgatggaaaa      480

atgggaagat tttttaatca tacattagta ttattaccag atggatgtgg aacattatta      540

agagcatttt attgtatttt agaaccaaga tctggaaatc attgtccagc aggaaattct      600

tatacatctt ttgcaacata tcatacacca gcaacagatt gttctgatgg aaattataat      660

agaaatgcat ctttaaattc ttttaaagaa tattttaatt taagaaattg tacatttatg      720

tatacatata atattacaga agatgaaatt ttagaatggt ttggaattac acaaacagca      780

caaggagtac atttattttc ttctagatat gtagatttat atggaggaaa tatgtttcaa      840

tttgcaacat taccagtata tgatacaatt aaatattatt ctattattcc acattctatt      900

agatctattc aatctgatag aaaagcatgg gcagcatttt atgtatataa attacaacca      960

ttaactttct tattagattt ctctgtagat ggatatatta gaagagcaat tgattgtgga     1020

tttaatgatt tatctcaatt acattgttct tatgaatctt ttgatgtaga atctggagta     1080

tattctgtat cttcttttga agcaaaacca tctggatctg tagtagaaca agcagaagga     1140

gtagaatgtg atttctctcc attattatct ggaacaccac cacaagtata taattttaaa     1200

agattagtat ttacaaattg taattataat ttaacaaaat tattatcttt attttctgta     1260

aatgatttta catgttctca aatttctcca gcagcaattg catctaattg ttattcttct     1320

ttaattttag attatttctc ttatccatta tctatgaaat ctgatttatc tgtatcttct     1380

gcaggaccaa tttctcaatt taattataaa caatctttct ctaatccaac atgtttaatt     1440

ttagcaacag taccacataa tttaacaaca attacaaaac cattaaaata ttcttatatt     1500

aataaatgtt ctagattatt atctgatgat agaacagaag taccacaatt agtaaatgca     1560

aatcaatatt ctccatgtgt atctattgta ccatctacag tatgggaaga tggagattat     1620

tatagaaaac aattatctcc attagaagga ggaggatggt tagtagcatc tggatctaca     1680

gtagcaatga cagaacaatt acaaatggga tttggaatta cagtacaata tggaacagat     1740

acaaattctg tatgtccaaa attagaattt gcaaatgata caaaaattgc atctcaatta     1800

ggaaattgtg tagaatattc tttatatgga gtatctggaa gaggagtatt tcaaaattgt     1860

acagcagtag gagtaagaca acaaagattt gtatatgatg catatcaaaa tttagtagga     1920

tattattctg atgatggaaa ttattattgt ttaagagcat gtgtatctgt accagtatct     1980

gtaatttatg ataaagaaac aaaaacacat gcaacattat ttggatctgt agcatgtgaa     2040

catatttctt ctacaatgtc tcaatattct agatctacaa gatctatgtt aaaaagaaga     2100

gattctacat atggaccatt acaaacacca gtaggatgtg tattaggatt agtaaattct     2160

tctttatttg tagaagattg taaattacca ttaggacaat ctttatgtgc attaccagat     2220

acaccatcta cattaacacc aagatctgta agatctgtac caggagaaat gagattagca     2280

tctattgcat ttaatcatcc aattcaagta gatcaattaa attcttctta ttttaaatta     2340

tctattccaa caaatttctc ttttggagta acacaagaat atattcaaac aacaattcaa     2400

aaagtaacag tagattgtaa acaatatgta tgtaatggat ttcaaaaatg tgaacaatta     2460

ttaagagaat atggacaatt ttgttctaaa attaatcaag cattacatgg agcaaattta     2520

agacaagatg attctgtaag aaatttattt gcatctgtaa aatcttctca atcttctcca     2580

attattccag gatttggagg agattttaat ttaacattat tagaaccagt atctatttct     2640

acaggatcta gatctgcaag atctgcaatt gaagatttat tatttgataa agtaacaatt     2700

gcagatccag gatatatgca aggatatgat gattgtatgc aacaaggacc agcatctgca     2760

agagatttaa tttgtgcaca atatgtagca ggatataaag tattaccacc attaatggat     2820

gtaaatatgg aagcagcata tacatcttct ttattaggat ctattgcagg agtaggatgg     2880

acagcaggat tatcttcttt tgcagcaatt ccatttgcac aatctatatt ctatagatta     2940

aatggagtag gaattacaca acaagtatta tctgaaaatc aaaaattaat tgcaaataaa     3000

tttaatcaag cattaggagc aatgcaaaca ggatttacaa caacaaatga agcatttaga     3060

aaagtacaag atgcagtaaa taataatgca caagcattat ctaaattagc atctgaatta     3120

tctaatacat ttggagcaat ttctgcatct attggagata ttattcaaag attagatgta     3180

ttagaacaag atgcacaaat tgatagatta attaatggaa gattaacaac attaaatgca     3240

tttgtagcac aacaattagt aagatctgaa tctgcagcat tatctgcaca attagcaaaa     3300

gataaagtaa atgaatgtgt aaaagcacaa tctaaaagat ctggattttg tggacaagga     3360

acacatattg tatcttttgt agtaaatgca ccaaatggat tatattttat gcatgtagga     3420

tattatccat ctaatcatat tgaagtagta tctgcatatg gattatgtga tgcagcaaat     3480

ccaacaaatt gtattgcacc agtaaatgga tattttatta aaacaaataa tacaagaatt     3540

gtagatgaat ggtcttatac aggatcttct ttctatgcac cagaaccaat tacatcttta     3600

aatacaaaat atgtagcacc acaagtaaca tatcaaaata tttctacaaa tttaccacca     3660

ccattattag gaaattctac aggaattgat tttcaagatg aattagatga attttttaaa     3720

aatgtatcta catctattcc aaattttgga tctttaacac aaattaatac aacattatta     3780

gatttaacat atgaaatgtt atctttacaa caagtagtaa aagcattaaa tgaatcttat     3840

attgatttaa aagaattagg aaattataca tattataata aatggccatg gtatatttgg     3900

ttaggattta ttgcaggatt agtagcatta gcattatgtg tattctttat tttatgttgt     3960

acaggatgtg gaacaaattg tatgggaaaa ttaaaatgta atagatgttg tgatagatat     4020

gaagaatatg atttagaacc acataaagta catgtacatt aa                        4062


<210>  5
<211>  1356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-3 (amino acid sequence)

<400>  5

Met Lys Leu Phe Leu Ile Leu Leu Val Leu Pro Leu Ala Ser Cys Phe 
1               5                   10                  15      


Phe Thr Cys Asn Ser Asn Ala Asn Leu Ser Met Leu Gln Leu Gly Val 
            20                  25                  30          


Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Thr His Trp 
        35                  40                  45              


Ile Cys Ala Asn Gln Ser Thr Ser Val Tyr Ser Ala Asn Gly Phe Phe 
    50                  55                  60                  


Tyr Ile Asp Val Gly Asn His Arg Ser Ala Phe Ala Leu His Thr Gly 
65                  70                  75                  80  


Tyr Tyr Asp Val Asn Gln Tyr Tyr Ile Tyr Val Thr Asn Glu Ile Gly 
                85                  90                  95      


Leu Asn Ala Ser Val Thr Leu Lys Ile Cys Lys Phe Gly Ile Asn Thr 
            100                 105                 110         


Thr Phe Asp Phe Leu Ser Asn Ser Ser Ser Ser Phe Asp Cys Ile Val 
        115                 120                 125             


Asn Leu Leu Phe Thr Glu Gln Leu Gly Ala Pro Leu Gly Ile Thr Ile 
    130                 135                 140                 


Ser Gly Glu Thr Val Arg Leu His Leu Tyr Asn Val Thr Arg Thr Phe 
145                 150                 155                 160 


Tyr Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr 
                165                 170                 175     


Phe Asn Tyr Ser Cys Val Phe Ser Val Val Asn Ala Thr Val Thr Val 
            180                 185                 190         


Asn Val Thr Thr His Asn Gly Arg Val Val Asn Tyr Thr Val Cys Asp 
        195                 200                 205             


Asp Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly 
    210                 215                 220                 


Arg Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn 
225                 230                 235                 240 


Gly Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg 
                245                 250                 255     


Leu Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe 
            260                 265                 270         


Val Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln 
        275                 280                 285             


His Asn Ser Val Ala Asp Val Met Arg Tyr Asn Leu Asn Phe Ser Ala 
    290                 295                 300                 


Asn Ser Val Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu 
305                 310                 315                 320 


Gln Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu 
                325                 330                 335     


Asp Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe 
            340                 345                 350         


Ile Asn Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Val 
        355                 360                 365             


Leu Pro Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe 
    370                 375                 380                 


Tyr Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val 
385                 390                 395                 400 


Asn Phe Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala 
                405                 410                 415     


Phe Ala Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Lys Ile 
            420                 425                 430         


Gln Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu 
        435                 440                 445             


His Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu 
    450                 455                 460                 


Asp Asp Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr 
465                 470                 475                 480 


Gln His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser 
                485                 490                 495     


Cys Tyr Val Cys Lys Pro His Gln Val Asn Ile Ser Leu Asn Gly Asn 
            500                 505                 510         


Thr Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr 
        515                 520                 525             


Asn Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr 
    530                 535                 540                 


Leu Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe 
545                 550                 555                 560 


Gln Lys Phe Lys Thr Ile Cys Phe Ser Thr Val Ala Val Pro Gly Ser 
                565                 570                 575     


Cys Asn Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile 
            580                 585                 590         


Val Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly 
        595                 600                 605             


Val Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu 
    610                 615                 620                 


Asn Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile 
625                 630                 635                 640 


Ile Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser 
                645                 650                 655     


Asn Ser Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile 
            660                 665                 670         


Phe Ile Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln 
        675                 680                 685             


Gln Ser Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly 
    690                 695                 700                 


Leu Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly 
705                 710                 715                 720 


Gly Asn Asn Cys Thr Thr Ala Val Met Thr Tyr Ser Asn Phe Gly Ile 
                725                 730                 735     


Cys Ala Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser Asp 
            740                 745                 750         


Asn Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn 
        755                 760                 765             


Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro 
    770                 775                 780                 


Ile Val Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys 
785                 790                 795                 800 


Lys Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp 
                805                 810                 815     


Ala Leu Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met 
            820                 825                 830         


Leu Thr Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe 
        835                 840                 845             


Gly Asp Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile His Ser 
    850                 855                 860                 


Ser Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys 
865                 870                 875                 880 


Val Val Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys 
                885                 890                 895     


Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn 
            900                 905                 910         


Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met 
        915                 920                 925             


Tyr Thr Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser 
    930                 935                 940                 


Ala Ala Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr 
945                 950                 955                 960 


Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala 
                965                 970                 975     


Ala Ser Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser 
            980                 985                 990         


Val Asn Asp Ala Ile Thr Gln Thr  Ala Glu Ala Ile His  Thr Val Thr 
        995                 1000                 1005             


Ile Ala  Leu Asn Lys Ile Gln  Asp Val Val Asn Gln  Gln Gly Ser 
    1010                 1015                 1020             


Ala Leu  Asn His Leu Thr Ser  Gln Leu Arg His Asn  Phe Gln Ala 
    1025                 1030                 1035             


Ile Ser  Asn Ser Ile Gln Ala  Ile Tyr Asp Arg Leu  Asp Ser Ile 
    1040                 1045                 1050             


Gln Ala  Asp Gln Gln Val Asp  Arg Leu Ile Thr Gly  Arg Leu Ala 
    1055                 1060                 1065             


Ala Leu  Asn Ala Phe Val Ser  Gln Val Leu Asn Lys  Tyr Thr Glu 
    1070                 1075                 1080             


Val Arg  Ser Ser Arg Arg Leu  Ala Gln Gln Lys Ile  Asn Glu Cys 
    1085                 1090                 1095             


Val Lys  Ser Gln Ser Asn Arg  Tyr Gly Phe Cys Gly  Asn Gly Thr 
    1100                 1105                 1110             


His Ile  Phe Ser Ile Val Asn  Ser Ala Pro Asp Gly  Leu Leu Phe 
    1115                 1120                 1125             


Leu His  Thr Val Leu Leu Pro  Thr Asp Tyr Lys Asn  Val Lys Ala 
    1130                 1135                 1140             


Trp Ser  Gly Ile Cys Val Asp  Gly Ile Tyr Gly Tyr  Val Leu Arg 
    1145                 1150                 1155             


Gln Pro  Asn Leu Val Leu Tyr  Ser Asp Asn Gly Val  Phe Arg Val 
    1160                 1165                 1170             


Thr Ser  Arg Val Met Phe Gln  Pro Arg Leu Pro Val  Leu Ser Asp 
    1175                 1180                 1185             


Phe Val  Gln Ile Tyr Asn Cys  Asn Val Thr Phe Val  Asn Ile Ser 
    1190                 1195                 1200             


Arg Val  Glu Leu His Thr Val  Ile Pro Asp Tyr Val  Asp Val Asn 
    1205                 1210                 1215             


Lys Thr  Leu Gln Glu Phe Ala  Gln Asn Leu Pro Lys  Tyr Val Lys 
    1220                 1225                 1230             


Pro Asn  Phe Asp Leu Thr Pro  Phe Asn Leu Thr Tyr  Leu Asn Leu 
    1235                 1240                 1245             


Ser Ser  Glu Leu Lys Gln Leu  Glu Ala Lys Thr Ala  Ser Leu Phe 
    1250                 1255                 1260             


Gln Thr  Thr Val Glu Leu Gln  Gly Leu Ile Asp Gln  Ile Asn Ser 
    1265                 1270                 1275             


Thr Tyr  Val Asp Leu Lys Leu  Leu Asn Arg Phe Glu  Asn Tyr Ile 
    1280                 1285                 1290             


Lys Trp  Pro Trp Trp Val Trp  Leu Ile Ile Ser Val  Val Phe Val 
    1295                 1300                 1305             


Val Leu  Leu Ser Leu Leu Val  Phe Cys Cys Leu Ser  Thr Gly Cys 
    1310                 1315                 1320             


Cys Gly  Cys Cys Asn Cys Leu  Thr Ser Ser Met Arg  Gly Cys Cys 
    1325                 1330                 1335             


Asp Cys  Gly Ser Thr Lys Leu  Pro Tyr Tyr Glu Phe  Glu Lys Val 
    1340                 1345                 1350             


His Val  Gln 
    1355     


<210>  6
<211>  4071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-3 (nucleic acid sequence)

<400>  6
atgaaattat ttttaatttt attagtatta ccattagcat cttgtttttt tacatgtaat       60

tctaatgcaa atttatctat gttacaatta ggagtaccag ataattcttc tacaattgta      120

acaggattat taccaacaca ttggatttgt gcaaatcaat ctacatctgt atattctgca      180

aatggattct tctatattga tgtaggaaat catagatctg catttgcatt acatacagga      240

tattatgatg taaatcaata ttatatttat gtaacaaatg aaattggatt aaatgcatct      300

gtaacattaa aaatttgtaa atttggaatt aatacaacat ttgatttctt atctaattct      360

tcttcttctt ttgattgtat tgtaaattta ttatttacag aacaattagg agcaccatta      420

ggaattacaa tttctggaga aacagtaaga ttacatttat ataatgtaac aagaacattt      480

tatgtaccag cagcatataa attaacaaaa ttatctgtaa aatgttattt taattattct      540

tgtgtatttt ctgtagtaaa tgcaacagta acagtaaatg taacaacaca taatggaaga      600

gtagtaaatt atacagtatg tgatgattgt aatggatata cagataatat tttctctgta      660

caacaagatg gaagaattcc aaatggattt ccatttaata attggttctt attaacaaat      720

ggatctacat tagtagatgg agtatctaga ttatatcaac cattaagatt aacatgttta      780

tggccagtac caggattaaa atcttctaca ggatttgtat attttaatgc aacaggatct      840

gatgtaaatt gtaatggata tcaacataat tctgtagcag atgtaatgag atataattta      900

aatttctctg caaattctgt agataattta aaatctggag taattgtatt taaaacatta      960

caatatgatg tattatttta ttgttctaat tcttcttctg gagtattaga tacaacaatt     1020

ccatttggac catcttctca accatattat tgttttatta attctacaat taatacaaca     1080

catgtatcta catttgtagg agtattacca ccaacagtaa gagaaattgt agtagcaaga     1140

acaggacaat tttatattaa tggatttaaa tattttgatt taggatttat tgaagcagta     1200

aattttaatg taacaacagc atctgcaaca gatttttgga cagtagcatt tgcaacattt     1260

gtagatgtat tagtaaatgt atctgcaaca aaaattcaaa atttattata ttgtgattct     1320

ccatttgaaa aattacaatg tgaacattta caatttggat tacaagatgg attttattct     1380

gcaaattttt tagatgataa tgtattacca gaaacatatg tagcattacc aatttattat     1440

caacatacag atattaattt tacagcaaca gcatcttttg gaggatcttg ttatgtatgt     1500

aaaccacatc aagtaaatat ttctttaaat ggaaatacat ctgtatgtgt aagaacatct     1560

catttctcta ttagatatat ttataataga gtaaaatctg gatctccagg agattcttct     1620

tggcatattt atttaaaatc tggaacatgt ccattttctt tctctaaatt aaataatttt     1680

caaaaattta aaacaatttg tttctctaca gtagcagtac caggatcttg taattttcca     1740

ttagaagcaa catggcatta tacatcttat acaattgtag gagcattata tgtaacatgg     1800

tctgaaggaa attctattac aggagtacca tatccagtat ctggaattag agaattttct     1860

aatttagtat taaataattg tacaaaatat aatatttatg attatgtagg aacaggaatt     1920

attagatctt ctaatcaatc tttagcagga ggaattacat atgtatctaa ttctggaaat     1980

ttattaggat ttaaaaatgt atctacagga aatatattca ttgtaacacc atgtaatcaa     2040

ccagatcaag tagcagtata tcaacaatct attattggag caatgacagc agtaaatgaa     2100

tctagatatg gattacaaaa tttattacaa ttaccaaact tctattatgt atctaatgga     2160

ggaaataatt gtacaacagc agtaatgaca tattctaatt ttggaatttg tgcagatgga     2220

tctttaattc cagtaagacc aagaaattct tctgataatg gaatttctgc aattattaca     2280

gcaaatttat ctattccatc taattggaca acatctgtac aagtagaata tttacaaatt     2340

acatctacac caattgtagt agattgtgca acatatgtat gtaatggaaa tccaagatgt     2400

aaaaatttat taaaacaata tacatctgca tgtaaaacaa ttgaagatgc attaagatta     2460

tctgcacatt tagaaacaaa tgatgtatct tctatgttaa catttgattc taatgcattt     2520

tctttagcaa atgtaacatc ttttggagat tataatttat cttctgtatt accacaaaga     2580

aatattcatt cttctagaat tgcaggaaga tctgcattag aagatttatt attttctaaa     2640

gtagtaacat ctggattagg aacagtagat gtagattata aatcttgtac aaaaggatta     2700

tctattgcag atttagcatg tgcacaatat tataatggaa ttatggtatt accaggagta     2760

gcagatgcag aaagaatggc aatgtataca ggatctttaa ttggaggaat ggtattagga     2820

ggattaacat ctgcagcagc aattccattt tctttagcat tacaagcaag attaaattat     2880

gtagcattac aaacagatgt attacaagaa aatcaaaaaa ttttagcagc atcttttaat     2940

aaagcaatta ataatattgt agcatctttc tcttctgtaa atgatgcaat tacacaaaca     3000

gcagaagcaa ttcatacagt aacaattgca ttaaataaaa ttcaagatgt agtaaatcaa     3060

caaggatctg cattaaatca tttaacatct caattaagac ataattttca agcaatttct     3120

aattctattc aagcaattta tgatagatta gattctattc aagcagatca acaagtagat     3180

agattaatta caggaagatt agcagcatta aatgcatttg tatctcaagt attaaataaa     3240

tatacagaag taagatcttc tagaagatta gcacaacaaa aaattaatga atgtgtaaaa     3300

tctcaatcta atagatatgg attttgtgga aatggaacac atattttctc tattgtaaat     3360

tctgcaccag atggattatt atttttacat acagtattat taccaacaga ttataagaat     3420

gtaaaagcat ggtctggaat ttgtgtagat ggaatttatg gatatgtatt aagacaacca     3480

aatttagtat tatattctga taatggagta tttagagtaa catctagagt aatgtttcaa     3540

ccaagattac cagtattatc tgattttgta caaatttata attgtaatgt aacatttgta     3600

aatatttcta gagtagaatt acatacagta attccagatt atgtagatgt aaataaaaca     3660

ttacaagaat ttgcacaaaa tttaccaaaa tatgtaaaac caaattttga tttaacacca     3720

tttaatttaa catatttaaa tttatcttct gaattaaaac aattagaagc aaaaacagca     3780

tctttatttc aaacaacagt agaattacaa ggattaattg atcaaattaa ttctacatat     3840

gtagatttaa aattattaaa tagatttgaa aattatatta aatggccatg gtgggtatgg     3900

ttaattattt ctgtagtatt tgtagtatta ttatctttat tagtattttg ttgtttatct     3960

acaggatgtt gtggatgttg taattgttta acatcttcta tgagaggatg ttgtgattgt     4020

ggatctacaa aattaccata ttatgaattt gaaaaagtac atgtacaata a              4071


<210>  7
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S E/L Promoter (nucleic acid sequence)

<400>  7
aaaaattgaa attttatttt ttttttttgg aatataaata ag                          42


<210>  8
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LEO Promoter (nucleic acid sequence)

<400>  8
ttttattttt tttttttgga atataaatat ccggtaaaat tgaaaaaata tacactaatt       60

agcgtctcgt ttcagacgct agctcgag                                          88


<210>  9
<211>  1270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-4 (amino acid sequence)

<400>  9

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys His Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Thr Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Pro Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Val Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Phe 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  10
<211>  3813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-4 (nucleic acid sequence)

<400>  10
atgtttgtat ttttagtatt attaccatta gtatcttctc aatgtgtaaa tttaactact       60

agaactcaat taccaccagc ttatactaat tcttttacta gaggagtata ttatccagat      120

aaagtattta gatcttctgt attacattct actcaagatt tatttttacc attcttctct      180

aatgtaactt ggtttcatgc tattcatgta tctggaacta atggaactaa aagatttgat      240

aatccagtat taccatttaa tgatggagta tattttgctt ctactgaaaa atctaatatt      300

attagaggat ggatttttgg aactacttta gattctaaaa ctcaatcttt attaattgta      360

aataatgcta ctaatgtagt aattaaagta tgtgaatttc aattttgtaa ttatccattc      420

ttatatcata aaaataataa atcttggatg gaatctgaat ttagagtata ttcttctgct      480

aataattgta cttttgaata tgtatctcaa ccatttttaa tggatttaga aggaaaacat      540

ggaaatttta aaaatttaag agaatttgta tttaaaaata ttgatggata ttttaaaatt      600

tattctaaac atactccaat taatttagta agagatttac cacaaggatt ttctgcttta      660

gaaccattag tagatttacc aattggaatt aatattacta gatttcaaac tttattagct      720

ttacatagat cttatttaac tccaggagat tcttcttctg gatggactgc tggagctgct      780

gcttattatg taggatattt acaaccaaga actttcttat taaaatataa tgaaaatgga      840

actattactg atgctgtaga ttgtgcttta gatccattat ctgaaactaa atgtacttta      900

aaatctttta ctgtagaaaa aggaatttat caaacttcta attttagagt acaaccaact      960

gaatctattg taagatttcc aaatattact aatttatgtc catttggaga agtatttaat     1020

gctactagat ttgcttctgt atatgcttgg aatagaaaaa gaatttctaa ttgtgtagct     1080

gattattctg tattatataa ttctgcttct ttctctactt ttaaatgtta tggagtatct     1140

ccaactaaat taaatgattt atgttttact aatgtatatg ctgattcttt tgtaattaga     1200

ggagatgaag taagacaaat tgctccagga caaactggaa ctattgctga ttataattat     1260

aaattaccag atgattttac tggatgtgta attgcttgga attctaataa tttagattct     1320

aaagtaggag gaaattataa ttatttatat agattattta gaaaatctaa tttaaaacca     1380

tttgaaagag atatttctac tgaaatttat caagctggat ctaaaccatg taatggagta     1440

aaaggattta attgttattt tccattacaa ccatatggat ttcaaccaac ttatggagta     1500

ggatatcaac catatagagt agtagtatta tcttttgaat tattacatgc tccagctact     1560

gtatgtggac caaaaaaatc tactaattta gtaaaaaata aatgtgtaaa ttttaatttt     1620

aatggattaa ctggaactgg agtattaact gaatctaata aaaaattttt accatttcaa     1680

caatttggaa gagatattgc tgatactact gatgctgtaa gagatccaca aactttagaa     1740

attttagata ttactccatg ttcttttgga ggagtatctg taattactcc aggaactaat     1800

acttctaatc aagtagctgt attatatcaa ggagtaaatt gtactgaagt accagtagct     1860

attcatgctg atcaattaac tccaacttgg agagtatatt ctactggatc taatgtattt     1920

caaactagag ctggatgttt aattggagct gaacatgtaa ataattctta tgaatgtgat     1980

attccaattg gagctggaat ttgtgcttct tatcaaactc aaactaattc tccaagaaga     2040

gctagatctg tagcttctca atctattatt gcttatacta tgtctttagg agctgaaaat     2100

tctgtagctt attctaataa ttctattgct attccaacta attttactat ttctgtaact     2160

actgaaattt taccagtatc tatgactaaa acttctgtag attgtactat gtatatttgt     2220

ggagattcta ctgaatgttc taatttatta ttacaatatg gatctttttg tactcaatta     2280

aatagagctt taactggaat tgctgtagaa caagataaaa atactcaaga agtatttgct     2340

caagtaaaac aaatttataa aactccacca attaaagatt ttggaggatt taatttctct     2400

caaattttac cagatccatc taaaccatct aaaagatctt ttattgaaga tttattattt     2460

aataaagtaa ctttagctga tgctggattt attaaacaat atggagattg tttaggagat     2520

attgctgcta gagatttaat ttgtgctcaa aaatttaatg gattaactgt attaccacca     2580

ttattaactg atgaaatggt agctcaatat acttctgctt tattagctgg aactattact     2640

tctggatgga cttttggagc tggagctgct ttacaaattc catttgctat gcaaatggct     2700

tatagattta atggaattgg agtaactcaa aatgtattat atgaaaatca aaaattaatt     2760

gctaatcaat ttaattctgc tattggaaaa attcaagatt ctttatcttc tactgcttct     2820

gctttaggaa aattacaaga tgtagtaaat caaaatgctc aagctttaaa tactttagta     2880

aaacaattat cttctaattt tggagctatt tcttctgtat taaatgatat tttatctaga     2940

ttagataaag tagaagctga agtacaaatt gatagattaa ttactggaag attacaatct     3000

ttacaaactt atgtaactca acaattaatt agagctgctg aaattagagc ttctgctaat     3060

ttagctgcta ctaaaatgtc tgaatgtgta ttaggacaat ctaaaagagt agatttttgt     3120

ggaaaaggat atcatttaat gtcttttcca caatctgctc cacatggagt agtattttta     3180

catgtaactt atgtaccagc tcaagaaaaa aattttacta ctgctccagc tatttgtcat     3240

gatggaaaag ctcattttcc aagagaagga gtatttgtat ctaatggaac tcattggttt     3300

gtaactcaaa gaaatttcta tgaaccacaa attattacta ctgataatac ttttgtatct     3360

ggaaattgtg atgtagtaat tggaattgta aataatactg tatatgatcc attacaacca     3420

gaattagatt cttttaaaga agaattagat aaatatttta aaaatcatac ttctccagat     3480

gtagatttag gagatatttc tggaattaat gcttcttttg taaatattca aaaagaaatt     3540

gatagattaa atgaagtagc taaaaattta aatgaatctt taattgattt acaagaatta     3600

ggaaaatatg aacaatatat taaatggcca tggtatattt ggttaggatt tattgctgga     3660

ttaattgcta ttgtaatggt aactattatg ttatgttgta tgacttcttg ttgttcttgt     3720

ttaaaaggat gttgttcttg tggatcttgt tgtaaatttg atgaagatga ttctgaacca     3780

gtattaaaag gagtaaaatt acattatact taa                                  3813


<210>  11
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M-B (amino acid sequence)

<400>  11

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  12
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M-B (nucleic acid sequence)

<400>  12
atgtttgtat ttttagtatt attaccatta gtatcttctc aatgtgtaaa tttaactact       60

agaactcaat taccaccagc ttatactaat tcttttacta gaggagtata ttatccagat      120

aaagtattta gatcttctgt attacattct actcaagatt tatttttacc attcttctct      180

aatgtaactt ggtttcatgc tattcatgta tctggaacta atggaactaa aagatttgat      240

aatccagtat taccatttaa tgatggagta tattttgctt ctactgaaaa atctaatatt      300

attagaggat ggatttttgg aactacttta gattctaaaa ctcaatcttt attaattgta      360

aataatgcta ctaatgtagt aattaaagta tgtgaatttc aattttgtaa tgatccattt      420

ttaggagtat attatcataa aaataataaa tcttggatgg aatctgaatt tagagtatat      480

tcttctgcta ataattgtac ttttgaatat gtatctcaac catttttaat ggatttagaa      540

ggaaaacaag gaaattttaa aaatttaaga gaatttgtat ttaaaaatat tgatggatat      600

tttaaaattt attctaaaca tactccaatt aatttagtaa gagatttacc acaaggattt      660

tctgctttag aaccattagt agatttacca attggaatta atattactag atttcaaact      720

ttattagctt tacatagatc ttatttaact ccaggagatt cttcttctgg atggactgct      780

ggagctgctg cttattatgt aggatattta caaccaagaa ctttcttatt aaaatataat      840

gaaaatggaa ctattactga tgctgtagat tgtgctttag atccattatc tgaaactaaa      900

tgtactttaa aatcttttac tgtagaaaaa ggaatttatc aaacttctaa ttttagagta      960

caaccaactg aatctattgt aagatttcca aatattacta atttatgtcc atttggagaa     1020

gtatttaatg ctactagatt tgcttctgta tatgcttgga atagaaaaag aatttctaat     1080

tgtgtagctg attattctgt attatataat tctgcttctt tctctacttt taaatgttat     1140

ggagtatctc caactaaatt aaatgattta tgttttacta atgtatatgc tgattctttt     1200

gtaattagag gagatgaagt aagacaaatt gctccaggac aaactggaaa aattgctgat     1260

tataattata aattaccaga tgattttact ggatgtgtaa ttgcttggaa ttctaataat     1320

ttagattcta aagtaggagg aaattataat tatttatata gattatttag aaaatctaat     1380

ttaaaaccat ttgaaagaga tatttctact gaaatttatc aagctggatc tactccatgt     1440

aatggagtag aaggatttaa ttgttatttt ccattacaat cttatggatt tcaaccaact     1500

aatggagtag gatatcaacc atatagagta gtagtattat cttttgaatt attacatgct     1560

ccagctactg tatgtggacc aaaaaaatct actaatttag taaaaaataa atgtgtaaat     1620

tttaatttta atggattaac tggaactgga gtattaactg aatctaataa aaaattttta     1680

ccatttcaac aatttggaag agatattgct gatactactg atgctgtaag agatccacaa     1740

actttagaaa ttttagatat tactccatgt tcttttggag gagtatctgt aattactcca     1800

ggaactaata cttctaatca agtagctgta ttatatcaag gagtaaattg tactgaagta     1860

ccagtagcta ttcatgctga tcaattaact ccaacttgga gagtatattc tactggatct     1920

aatgtatttc aaactagagc tggatgttta attggagctg aacatgtaaa taattcttat     1980

gaatgtgata ttccaattgg agctggaatt tgtgcttctt atcaaactca aactaattct     2040

ccaagaagag ctagatctgt agcttctcaa tctattattg cttatactat gtctttagga     2100

gctgaaaatt ctgtagctta ttctaataat tctattgcta ttccaactaa ttttactatt     2160

tctgtaacta ctgaaatttt accagtatct atgactaaaa cttctgtaga ttgtactatg     2220

tatatttgtg gagattctac tgaatgttct aatttattat tacaatatgg atctttttgt     2280

actcaattaa atagagcttt aactggaatt gctgtagaac aagataaaaa tactcaagaa     2340

gtatttgctc aagtaaaaca aatttataaa actccaccaa ttaaagattt tggaggattt     2400

aatttctctc aaattttacc agatccatct aaaccatcta aaagatcttt tattgaagat     2460

ttattattta ataaagtaac tttagctgat gctggattta ttaaacaata tggagattgt     2520

ttaggagata ttgctgctag agatttaatt tgtgctcaaa aatttaatgg attaactgta     2580

ttaccaccat tattaactga tgaaatgatt gctcaatata cttctgcttt attagctgga     2640

actattactt ctggatggac ttttggagct ggagctgctt tacaaattcc atttgctatg     2700

caaatggctt atagatttaa tggaattgga gtaactcaaa atgtattata tgaaaatcaa     2760

aaattaattg ctaatcaatt taattctgct attggaaaaa ttcaagattc tttatcttct     2820

actgcttctg ctttaggaaa attacaagat gtagtaaatc aaaatgctca agctttaaat     2880

actttagtaa aacaattatc ttctaatttt ggagctattt cttctgtatt aaatgatatt     2940

ttatctagat tagataaagt agaagctgaa gtacaaattg atagattaat tactggaaga     3000

ttacaatctt tacaaactta tgtaactcaa caattaatta gagctgctga aattagagct     3060

tctgctaatt tagctgctac taaaatgtct gaatgtgtat taggacaatc taaaagagta     3120

gatttttgtg gaaaaggata tcatttaatg tcttttccac aatctgctcc acatggagta     3180

gtatttttac atgtaactta tgtaccagct caagaaaaaa attttactac tgctccagct     3240

atttgtcatg atggaaaagc tcattttcca agagaaggag tatttgtatc taatggaact     3300

cattggtttg taactcaaag aaatttctat gaaccacaaa ttattactac tgataatact     3360

tttgtatctg gaaattgtga tgtagtaatt ggaattgtaa ataatactgt atatgatcca     3420

ttacaaccag aattagattc ttttaaagaa gaattagata aatattttaa aaatcatact     3480

tctccagatg tagatttagg agatatttct ggaattaatg cttctgtagt aaatattcaa     3540

aaagaaattg atagattaaa tgaagtagct aaaaatttaa atgaatcttt aattgattta     3600

caagaattag gaaaatatga acaatatatt aaatggccat ggtatatttg gttaggattt     3660

attgctggat taattgctat tgtaatggta actattatgt tatgttgtat gacttcttgt     3720

tgttcttgtt taaaaggatg ttgttcttgt ggatcttgtt gtaaatttga tgaagatgat     3780

tctgaaccag tattaaaagg agtaaaatta cattatactt aa                        3822


<210>  13
<211>  1347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 (amino acid sequence)

<400>  13

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        915                 920                 925             


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile 
    930                 935                 940                 


Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp 
945                 950                 955                 960 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                965                 970                 975     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            980                 985                 990         


Asn Gln Lys Gln Ile Ala Asn Gln  Phe Asn Lys Ala Ile  Ser Gln Ile 
        995                 1000                 1005             


Gln Glu  Ser Leu Thr Thr Thr  Ser Thr Ala Leu Gly  Lys Leu Gln 
    1010                 1015                 1020             


Asp Val  Val Asn Gln Asn Ala  Gln Ala Leu Asn Thr  Leu Val Lys 
    1025                 1030                 1035             


Gln Leu  Ser Ser Asn Phe Gly  Ala Ile Ser Ser Val  Leu Asn Asp 
    1040                 1045                 1050             


Ile Leu  Ser Arg Leu Asp Pro  Pro Glu Ala Glu Val  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
    1070                 1075                 1080             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1085                 1090                 1095             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1100                 1105                 1110             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1115                 1120                 1125             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1130                 1135                 1140             


Ser Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1145                 1150                 1155             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1160                 1165                 1170             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1175                 1180                 1185             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1190                 1195                 1200             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1205                 1210                 1215             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1220                 1225                 1230             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1235                 1240                 1245             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1250                 1255                 1260             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1265                 1270                 1275             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1280                 1285                 1290             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1295                 1300                 1305             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1310                 1315                 1320             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1325                 1330                 1335             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1340                 1345         


<210>  14
<211>  4044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M5 (nucleic acid sequence)

<400>  14
atgatccatt ctgtcttctt gcttatgttt ttgttgacgc ccactgagtc ttacgtggac       60

gtgggcccgg actctgttaa gagcgcatgc attgaggtcg atatacaaca aacatttttt      120

gacaagacct ggccccggcc gatagacgtt agcaaagcag atggaataat ttatccccag      180

gggcgtactt attccaacat aacgatcaca taccagggcc tgttcccgta tcaaggcgac      240

cacggtgata tgtacgtata cagtgcgggc catgcgacgg gcacgacgcc gcagaagttg      300

tttgtagcca actacagtca agatgtcaag caattcgcca acggcttcgt cgtacgcatc      360

ggtgcagctg cgaattctac cggtaccgtg attattagtc cgtcgacctc agctaccatt      420

cgaaaaatct atccagcgtt catgctcggt tcctcagttg ggaacttttc tgacgggaaa      480

atgggtcggt tcttcaatca taccctcgtc ctcctcccag atggatgcgg cacactgctt      540

cgcgccttct attgcatact agaaccaaga tccggcaacc attgccctgc agggaacagc      600

tatacatcct ttgcaaccta tcacactcca gcgaccgact gttctgatgg taactataat      660

agaaatgcgt cactaaacag ctttaaggag tattttaatt tacgcaactg tacctttatg      720

tacacgtata atatcacaga ggatgagatt ctcgagtggt tcggtataac tcaaacggct      780

caaggggtgc atttattctc ctcacggtat gtcgacctgt acggcggaaa tatgttccaa      840

ttcgccacct tgccggtata cgacactatt aagtactact ctattatccc acatagcatc      900

cgttcaatcc agagtgatcg caaagcttgg gctgcgttct atgtgtacaa gttgcaaccc      960

ttaactttct tgctagactt tagcgtcgat ggttacatcc gaagagccat tgactgtgga     1020

ttcaacgacc tatcgcaact gcattgttca tacgagtcgt tcgatgtcga aagcggtgtt     1080

tattcagtca gtagctttga agccaagccg tcgggctctg ttgtcgaaca ggcggaagga     1140

gtagaatgcg acttttcccc gctactatca ggcactcctc ctcaagtgta caatttcaaa     1200

agactagtat tcacaaactg taattacaac cttaccaaat tactatcgct cttttccgtc     1260

aacgatttta cctgctcaca gatttctcct gccgcgatag catctaattg ctactcttct     1320

ttgattcttg attacttttc gtatccactt tccatgaagt ctgatttgtc agtatcctct     1380

gctggcccga tctcccagtt taattacaag cagtctttta gtaatcccac gtgtctaatt     1440

cttgctaccg tacctcacaa cttaacaacg ataacaaagc ccctaaagta ctcgtacatt     1500

aacaagtgtt ccaggttact gtcggatgat cggacggagg ttccacaatt agtcaacgcc     1560

aaccaatact caccatgcgt gtccatagtg ccctccacag tatgggaaga tggagattac     1620

tatcggaaac agctatctcc attagaaggg gggggttggc ttgtcgcctc aggatccaca     1680

gtagctatga ctgagcaatt acaaatgggt tttgggatca cggtgcagta cgggacggac     1740

acaaatagtg tatgtccaaa gctagagttc gccaatgaca ccaaaatcgc ctcacagcta     1800

ggcaattgtg tggaatattc tttatatggt gtttcgggcc gaggagtatt ccagaattgt     1860

accgccgttg gagttcggca acagaggttc gtttatgatg cctaccaaaa tctggtcggc     1920

tattattcgg atgacggtaa ctattattgc ttaagagcat gcgtttccgt acccgttagc     1980

gttatctacg ataaggaaac aaaaacccat gcaacactat ttggtagcgt agcctgtgaa     2040

catatctcgt ccaccatgtc gcagtattcc aggtctactc gttccatgct gaagcggcgt     2100

gactctacat atggaccact gcagactccg gtggggtgcg tattgggact cgtcaattct     2160

agtctttttg tagaagattg taaattgccc ctgggacaat ctttatgcgc tctgccagat     2220

acaccaagta ctttgacacc acgaagtgtg aggtcggtgc ccggtgaaat gcgtcttgca     2280

tcgattgcgt tcaaccaccc tatacaagtc gaccaattaa attcctccta ttttaaactt     2340

tcaatcccaa ctaacttttc ttttggggtg acgcaggaat atatccaaac caccatccaa     2400

aaagtcaccg tagattgcaa gcagtacgtg tgtaatggtt ttcaaaaatg cgagcaactt     2460

ttacgagagt acggtcagtt ctgttccaaa atcaatcaag ctctccacgg ggcgaacttg     2520

aggcaagacg actcggtacg taatctgttt gcctccgtca aaagttcgca atcgtctccg     2580

atcatcccgg gcttcggggg agactttaat ctgacgctgc tagaacctgt atcaatttcc     2640

acgggctcga gaagcgccag gagtgccata gaggacctac tgttcgacaa agtaacgata     2700

gcagaccctg gatacatgca gggttatgat gactgtatgc agcaaggccc cgctagcgct     2760

cgagacttga tttgcgcaca aaagtttaat ggtctcaccg tgcttccccc gctactgact     2820

gatgacatga tcgccgcata tacggcagcg ttagtatccg gaacggcaac agcgggttgg     2880

acattcggcg caggcgctgc cttacagata ccattcgcaa tgcagatggc ataccgattc     2940

aacggtatcg gggttaccca gaacgtactt tatgaaaacc aaaaacaaat tgccaaccaa     3000

ttcaataaag caatttcgca gatccaggag agcttgacaa caacgtcgac ggccctcggc     3060

aagctacagg acgtggtaaa ccagaatgca caggctctta atacacttgt aaaacagtta     3120

tcatcaaatt ttggcgcgat ctcttctgtg ctgaatgaca tcctgtcgcg tctcgatcca     3180

cctgaggcgg aggtccagat agacaggttg ataacgggtc gtttacagtc attgcagaca     3240

tacgttacac aacaactcat tcgagcagca gagatacgcg cgtccgctaa cctagcggct     3300

accaaaatgt ccgaatgtgt gctaggccaa tcgaaacgag tagatttctg tgggaaaggc     3360

taccacctca tgtcctttcc ccaagcagct ccacatggcg tggtctttct acatgtcacg     3420

tacgtgcctt cacaagaaaa gaattttacc accgcgcctg caatttgcca cgaggggaaa     3480

gcctattttc cgagggaagg ggttttcgtt ttcaatggga cctcttggtt cattacccaa     3540

cgtaatttct tctcgccaca aattattact acggacaata ctttcgtaag tgggaactgt     3600

gatgtagtta ttggaataat caacaataca gtctatgacc ccctccagcc agaactggac     3660

tctttcaaag aagagcttga taagtatttc aagaatcaca ccagccctga cgtggaccta     3720

ggagatatat cagggataaa cgcatcagtg gtgaatatac agaaggagat tgaccggcta     3780

aacgaagtcg cgaagaacct taacgagtcg ttaattgacc tgcaagaact cgggaagtac     3840

gaacagtaca ttaagtggcc ttggtacgta tggttagggt ttatagccgg actcatcgcg     3900

atagtcatgg tgactattct cctctgctgc atgacatctt gctgcagctg tctgaagggg     3960

gcatgtagtt gtggcagctg ttgcaaattt gacgaggatg atagcgaacc ggtgcttaag     4020

ggcgtaaaat tacactacac ctaa                                            4044


<210>  15
<211>  1347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 + D510G (amino acid sequence)

<400>  15

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Gly Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        915                 920                 925             


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile 
    930                 935                 940                 


Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp 
945                 950                 955                 960 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                965                 970                 975     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            980                 985                 990         


Asn Gln Lys Gln Ile Ala Asn Gln  Phe Asn Lys Ala Ile  Ser Gln Ile 
        995                 1000                 1005             


Gln Glu  Ser Leu Thr Thr Thr  Ser Thr Ala Leu Gly  Lys Leu Gln 
    1010                 1015                 1020             


Asp Val  Val Asn Gln Asn Ala  Gln Ala Leu Asn Thr  Leu Val Lys 
    1025                 1030                 1035             


Gln Leu  Ser Ser Asn Phe Gly  Ala Ile Ser Ser Val  Leu Asn Asp 
    1040                 1045                 1050             


Ile Leu  Ser Arg Leu Asp Pro  Pro Glu Ala Glu Val  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
    1070                 1075                 1080             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1085                 1090                 1095             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1100                 1105                 1110             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1115                 1120                 1125             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1130                 1135                 1140             


Ser Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1145                 1150                 1155             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1160                 1165                 1170             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1175                 1180                 1185             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1190                 1195                 1200             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1205                 1210                 1215             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1220                 1225                 1230             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1235                 1240                 1245             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1250                 1255                 1260             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1265                 1270                 1275             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1280                 1285                 1290             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1295                 1300                 1305             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1310                 1315                 1320             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1325                 1330                 1335             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1340                 1345         


<210>  16
<211>  1347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 + I529T (amino acid sequence)

<400>  16

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Thr Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        915                 920                 925             


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile 
    930                 935                 940                 


Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp 
945                 950                 955                 960 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                965                 970                 975     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            980                 985                 990         


Asn Gln Lys Gln Ile Ala Asn Gln  Phe Asn Lys Ala Ile  Ser Gln Ile 
        995                 1000                 1005             


Gln Glu  Ser Leu Thr Thr Thr  Ser Thr Ala Leu Gly  Lys Leu Gln 
    1010                 1015                 1020             


Asp Val  Val Asn Gln Asn Ala  Gln Ala Leu Asn Thr  Leu Val Lys 
    1025                 1030                 1035             


Gln Leu  Ser Ser Asn Phe Gly  Ala Ile Ser Ser Val  Leu Asn Asp 
    1040                 1045                 1050             


Ile Leu  Ser Arg Leu Asp Pro  Pro Glu Ala Glu Val  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
    1070                 1075                 1080             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1085                 1090                 1095             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1100                 1105                 1110             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1115                 1120                 1125             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1130                 1135                 1140             


Ser Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1145                 1150                 1155             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1160                 1165                 1170             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1175                 1180                 1185             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1190                 1195                 1200             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1205                 1210                 1215             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1220                 1225                 1230             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1235                 1240                 1245             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1250                 1255                 1260             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1265                 1270                 1275             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1280                 1285                 1290             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1295                 1300                 1305             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1310                 1315                 1320             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1325                 1330                 1335             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1340                 1345         


<210>  17
<211>  1347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M5 + D510G + I529T (amino acid sequence)

<400>  17

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Gly Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Thr Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        915                 920                 925             


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile 
    930                 935                 940                 


Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp 
945                 950                 955                 960 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                965                 970                 975     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            980                 985                 990         


Asn Gln Lys Gln Ile Ala Asn Gln  Phe Asn Lys Ala Ile  Ser Gln Ile 
        995                 1000                 1005             


Gln Glu  Ser Leu Thr Thr Thr  Ser Thr Ala Leu Gly  Lys Leu Gln 
    1010                 1015                 1020             


Asp Val  Val Asn Gln Asn Ala  Gln Ala Leu Asn Thr  Leu Val Lys 
    1025                 1030                 1035             


Gln Leu  Ser Ser Asn Phe Gly  Ala Ile Ser Ser Val  Leu Asn Asp 
    1040                 1045                 1050             


Ile Leu  Ser Arg Leu Asp Pro  Pro Glu Ala Glu Val  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
    1070                 1075                 1080             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1085                 1090                 1095             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1100                 1105                 1110             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1115                 1120                 1125             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1130                 1135                 1140             


Ser Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1145                 1150                 1155             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1160                 1165                 1170             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1175                 1180                 1185             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1190                 1195                 1200             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1205                 1210                 1215             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1220                 1225                 1230             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1235                 1240                 1245             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1250                 1255                 1260             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1265                 1270                 1275             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1280                 1285                 1290             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1295                 1300                 1305             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1310                 1315                 1320             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1325                 1330                 1335             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1340                 1345         


<210>  18
<211>  1347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mosaic MERS-CoV/Bat SARS-like CoV S Protein

<400>  18

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Lys 
        915                 920                 925             


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile 
    930                 935                 940                 


Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp 
945                 950                 955                 960 


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
                965                 970                 975     


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
            980                 985                 990         


Asn Gln Lys Gln Ile Ala Asn Gln  Phe Asn Lys Ala Ile  Ser Gln Ile 
        995                 1000                 1005             


Gln Glu  Ser Leu Thr Thr Thr  Ser Thr Ala Leu Gly  Lys Leu Gln 
    1010                 1015                 1020             


Asp Val  Val Asn Gln Asn Ala  Gln Ala Leu Asn Thr  Leu Val Lys 
    1025                 1030                 1035             


Gln Leu  Ser Ser Asn Phe Gly  Ala Ile Ser Ser Val  Leu Asn Asp 
    1040                 1045                 1050             


Ile Leu  Ser Arg Leu Asp Lys  Val Glu Ala Glu Val  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
    1070                 1075                 1080             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1085                 1090                 1095             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1100                 1105                 1110             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1115                 1120                 1125             


Ala Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1130                 1135                 1140             


Ser Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1145                 1150                 1155             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Phe Asn Gly 
    1160                 1165                 1170             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Phe Ser  Pro Gln Ile 
    1175                 1180                 1185             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1190                 1195                 1200             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1205                 1210                 1215             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1220                 1225                 1230             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1235                 1240                 1245             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1250                 1255                 1260             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1265                 1270                 1275             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1280                 1285                 1290             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1295                 1300                 1305             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1310                 1315                 1320             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1325                 1330                 1335             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1340                 1345         


