                         SEQUENCE LISTING

<110>  Cilian AG
 
<120>  Purification of Proteins

<130>  CD43131

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Tetrahymena thermophila

<400>  1

Met Lys Leu Gln Leu Leu Leu Leu Val Cys Leu Ser Phe Ala Ala Cys 
1               5                   10                  15      


Gln Ser Phe Thr Tyr Thr Gln Ser Leu Ala Gln Asp Leu Ala Gly Phe 
            20                  25                  30          


Ser Leu Ala Ser Tyr Cys Asn Pro Lys Ser Ile Glu Gln Trp Asn Cys 
        35                  40                  45              


Gly Cys Ala Cys Asp Lys Asn Pro Gln Gly Leu Arg Asn Val Thr Ile 
    50                  55                  60                  


Leu Phe Asn Ser Thr Leu Gln Ala Ser Gly Tyr Leu Gly Tyr Ser Thr 
65                  70                  75                  80  


His His Asp Ala Ile Val Val Val Phe Arg Gly Thr Val Pro Trp Leu 
                85                  90                  95      


Ile Glu Asn Trp Ile Ala Asp Leu Asn Thr Phe Lys Thr Gln Tyr Pro 
            100                 105                 110         


Leu Cys Gln Asn Cys Tyr Val His Gln Gly Phe Tyr Asn Gln Phe Lys 
        115                 120                 125             


Gln Leu Lys Ser Gln Leu Val Thr Ser Phe Thr Ser Leu Arg Gln Leu 
    130                 135                 140                 


Tyr Pro Asn Ala Lys Val Phe Val Thr Gly His Ser Leu Gly Ala Ala 
145                 150                 155                 160 


Met Ser Ala His Ser Ile Pro Val Ile Tyr Gln Leu Asn Gly Asn Lys 
                165                 170                 175     


Pro Ile Asp Ala Phe Tyr Asn Tyr Gly Cys Pro Arg Val Gly Asp Gln 
            180                 185                 190         


Thr Tyr Ala Asn Trp Phe Asn Ser Gln Asn Phe Ala Leu Glu Tyr Gly 
        195                 200                 205             


Arg Ile Asn Asn Ala Ala Asp Pro Val Pro His Leu Pro Pro Leu Leu 
    210                 215                 220                 


Tyr Pro Phe Ser Phe Phe His Tyr Asn His Glu Ile Phe Tyr Pro Ser 
225                 230                 235                 240 


Phe Val Leu Phe Gly Asn Gln His Asn Gln Cys Gln Asn Ala Glu Thr 
                245                 250                 255     


Ile Phe Gly Ala Asp Gly Val Ile Ile Ala Ala Asn Val Leu Asp His 
            260                 265                 270         


Leu Thr Tyr Phe Gly Trp Asp Trp Ser Gly Ser Ile Leu Thr Cys Gln 
        275                 280                 285             


<210>  2
<211>  288
<212>  PRT
<213>  Tetrahymena thermophila

<400>  2

Met Lys Ser Ile Phe Leu Leu Ile Ile Ser Leu Leu Leu Ala Ser Cys 
1               5                   10                  15      


Ser Gln Phe Gln Tyr Asn Glu Thr Leu Ala Gln Asp Leu Ala Gly Phe 
            20                  25                  30          


Ser Leu Ala Ser Tyr Cys Asn Pro Lys Tyr Leu Gln Gln Trp Asn Cys 
        35                  40                  45              


Gly Ser Ala Cys Lys Lys Asn Pro Asn Gly Leu Thr Asp Phe Ser Tyr 
    50                  55                  60                  


Leu Tyr Asn Lys Thr Leu Lys Ala Ser Gly Tyr Ile Gly Tyr Ser Ala 
65                  70                  75                  80  


His His Asp Ala Ile Ile Val Val Phe Arg Gly Thr Val Pro Trp Leu 
                85                  90                  95      


Ile Gln Asn Trp Ile Ala Asp Leu Asn Thr Ile Lys Ile Gln Tyr Pro 
            100                 105                 110         


Phe Cys Glu Asn Cys Tyr Val His Lys Gly Phe Tyr Lys Gln Phe Asn 
        115                 120                 125             


Gln Leu Lys Ser Gln Leu Ile Gln Ser Phe Thr Glu Ile Arg Gln Lys 
    130                 135                 140                 


Tyr Pro Ser Ser Lys Ile Phe Val Thr Gly His Ser Leu Gly Ala Ala 
145                 150                 155                 160 


Met Ser Phe His Ser Met Pro Ile Ile Phe Glu Leu Asn Gly Asn Lys 
                165                 170                 175     


Pro Ile Asp Ala Phe Tyr Asn Tyr Gly Ser Pro Arg Val Gly Asn Glu 
            180                 185                 190         


Ala Tyr Ala Thr Trp Phe Asn Leu Gln Asn Phe Ala Leu Gln Tyr Gly 
        195                 200                 205             


Arg Ile Asn Asn Ala Ala Asp Pro Val Pro His Leu Pro Pro Ile Leu 
    210                 215                 220                 


Phe Pro Phe Gln Phe Tyr His Thr Asn His Glu Ile Phe Tyr Thr Ser 
225                 230                 235                 240 


Phe Ile Glu Asp Gly Asn Lys Tyr Glu Gln Cys Leu Asp Ala Glu His 
                245                 250                 255     


Lys Leu Cys Ala Asn Ser Lys Ile Ile Ala Ala Ser Val Arg Asp His 
            260                 265                 270         


Leu Ser Tyr Phe Gly Trp Asn Trp Ala Thr Ser Ile Leu Thr Cys Gln 
        275                 280                 285             


<210>  3
<211>  308
<212>  PRT
<213>  Tetrahymena thermophila

<400>  3

Met Asn Lys Leu Gln Val Leu Phe Ile Ala Ala Ile Val Cys Thr Ile 
1               5                   10                  15      


Gly Ser Thr Val Tyr Leu Leu Asn Lys Ser Ser Ser Asp Val Gln Glu 
            20                  25                  30          


Ser Gln Leu Thr Phe Pro Tyr Asp Glu Asn Leu Ala Glu Asn Leu Ala 
        35                  40                  45              


Gly Phe Ser Met Ala Ser Tyr Cys Lys Ala Ser Lys Ile Glu Asn Trp 
    50                  55                  60                  


Asn Cys Gly Ala Ser Cys Lys Lys Asn Pro Glu Gly Leu Gln Asp Val 
65                  70                  75                  80  


Tyr Ile Met Lys Asn Lys Thr Met Asn Ala Ala Gly Phe Leu Ala Tyr 
                85                  90                  95      


Ser Pro Ala His Asp Ala Ile Val Val Val Phe Arg Gly Thr Val Pro 
            100                 105                 110         


Trp Leu Ile Lys Asn Trp Ile Ser Asp Ile Asn Thr Val Lys Thr Lys 
        115                 120                 125             


Tyr Ser Arg Cys Glu Lys Cys Tyr Val His Leu Gly Phe Phe Asn Ala 
    130                 135                 140                 


Phe Lys Glu Leu Gln Asp Gln Ile Leu Thr Glu Phe Pro Lys Leu Lys 
145                 150                 155                 160 


Ala Lys Tyr Pro Tyr Ser Lys Asn Ile Asn Tyr Ser Lys Leu Asn Arg 
                165                 170                 175     


Arg His Ser Leu Gly Ala Ala Met Ser Thr His Ala Val Pro Val Ile 
            180                 185                 190         


Tyr Glu Leu Asn Gly Asn Lys Pro Ile Asp Ala Phe Tyr Asn Phe Gly 
        195                 200                 205             


Ser Pro Arg Val Gly Asp Glu Asn Tyr His Gln Trp Phe Asp Ser Gln 
    210                 215                 220                 


Asn Phe Thr Leu Gln Tyr Gly Arg Ile Asn His Arg Ala Asp Pro Val 
225                 230                 235                 240 


Pro His Leu Pro Pro Asn Tyr Ser Pro Phe Thr Phe Thr His Ile Asp 
                245                 250                 255     


His Glu Val Phe Tyr Gln Thr Phe Lys Lys Pro Tyr Thr Gln Cys Ile 
            260                 265                 270         


Glu Thr Glu Ser Leu Glu Cys Ala Asp Gly Ile Lys Ile Pro Leu Asp 
        275                 280                 285             


Ile Pro Asp His Leu Ser Tyr Phe Gly Trp Asp Trp Ala Thr Asp Ile 
    290                 295                 300                 


Leu Ala Cys Gln 
305             


<210>  4
<211>  486
<212>  PRT
<213>  Tetrahymena thermophila

<400>  4

Met Ser Lys Leu Gln Phe Val Leu Ile Ala Ala Leu Leu Leu Val Ala 
1               5                   10                  15      


Val Ser Ala Lys Thr Ala Gln Glu Trp Lys Thr Arg Asn Ile Tyr Gln 
            20                  25                  30          


Ile Ile Thr Asp Arg Phe Ala Leu Gly Asp Gly Ser Lys Pro Tyr Cys 
        35                  40                  45              


Asp Leu Asn Lys Gln Pro Tyr Tyr Cys Gly Gly Asn Phe Lys Gly Ile 
    50                  55                  60                  


Glu Asn Asn Leu Asp Tyr Ile Gln Gly Met Gly Phe Asn Ala Ile Trp 
65                  70                  75                  80  


Ile Ser Pro Val Pro Asp Asn Tyr Pro Asn Gln Phe His Gly Tyr Ala 
                85                  90                  95      


Ala Lys Asn Met Thr Glu Ile Asn Ser His Phe Gly Gly Ala Asp Gly 
            100                 105                 110         


Leu Lys Ser Leu Ile Asp Ala Cys His Lys Arg Asp Ile Trp Val Met 
        115                 120                 125             


Ile Asp Val Val Ala Asn His Met Gly Asn Thr Asp Gln Asn Tyr Ser 
    130                 135                 140                 


Glu Asn Ile Pro Phe Asn Ser Pro Asp His Tyr His Ser Tyr Cys Ile 
145                 150                 155                 160 


Ile Ser Asp Ser Asp Phe Ala Thr Lys Asn Met Tyr Asn Ile Gln His 
                165                 170                 175     


Cys Arg Leu Ala Gly Leu Ala Asp Leu Asn Gln Glu Asn Ser Tyr Val 
            180                 185                 190         


Ser Asn Tyr Leu Val Asn Trp Ile Lys Asp Leu Val Gln Thr Tyr Asn 
        195                 200                 205             


Val Asp Gly Ile Arg Ile Asp Thr Val Pro Glu Val His Pro Asp Phe 
    210                 215                 220                 


Trp Lys Gln Tyr Thr Thr Ser Ala Gly Val Phe Ala Thr Gly Glu Val 
225                 230                 235                 240 


Phe Asp Gly Asp Phe Gly Tyr Val Ala Ser Tyr Ile Pro Ser Val Gly 
                245                 250                 255     


Ser Val Leu Asn Tyr Pro Trp Tyr Phe Asn Met Arg Asp Ile Phe Val 
            260                 265                 270         


Asn Gln Lys Asp Met Trp Gly Val Arg Thr Tyr Tyr Gln Asn Trp Ala 
        275                 280                 285             


Asn Gln His Ala Asp Leu Ser Ile Leu Thr Pro Phe Val Asp Asn His 
    290                 295                 300                 


Asp Asn Pro Arg Phe Leu Ser Asp Gln Val Phe Asn Asn Gly Lys Asp 
305                 310                 315                 320 


Arg Asn Thr Arg Ile Gln Leu Leu Lys Gly Tyr Thr Thr Phe Thr Leu 
                325                 330                 335     


Thr Ser Ile Gly Ile Pro Ile Leu Tyr Tyr Gly Thr Glu Gln Tyr Phe 
            340                 345                 350         


Ser Gly Asn Thr Asp Pro Tyr Asp Arg Glu Pro Leu Trp Asn Ser Leu 
        355                 360                 365             


Asn Thr Asn Ser Asp Met Tyr Lys Tyr Val Gln Ser Ile Leu Tyr Ala 
    370                 375                 380                 


Lys Asn Ile Thr Asn Ala Gly Leu Gln Gly Gln Thr Glu Ala Tyr Cys 
385                 390                 395                 400 


Asp Gln Asp Leu Tyr Ala Phe Phe Arg Gly Lys Leu Phe Val Gly Val 
                405                 410                 415     


Thr Ser Lys Phe Asn Gln Val Thr Arg Gln Ile Val Thr His Pro Phe 
            420                 425                 430         


Ser Asn Gly Glu Val Ile Cys Asn Ile Phe Tyr Pro Thr Gln Asp Cys 
        435                 440                 445             


Leu Thr Ile Thr Asn Asn Ser Phe Asn Leu Val Leu Ile Gly Gly Glu 
    450                 455                 460                 


Ala Lys Ile Phe Val Pro Lys Ser Leu Leu Gln Lys Ser Ser Gln Phe 
465                 470                 475                 480 


Leu Arg Ser Ala Ser Ser 
                485     


<210>  5
<211>  324
<212>  PRT
<213>  Tetrahymena thermophila

<400>  5

Met Ser Gln Lys Ile Thr Val Thr Leu Val Ala Ile Ala Ala Ile Ala 
1               5                   10                  15      


Ala Ile Thr Ala Ala Gly Ile Tyr Tyr Gln Asn His Gln Ala Ser Gln 
            20                  25                  30          


Leu Glu Lys Ser Phe Lys Arg Asn Thr Ile Leu Glu Gln Trp Asn Glu 
        35                  40                  45              


Phe Lys Gln Lys Phe Gly Lys Lys Tyr Ala Asp Gln Glu Phe Glu Arg 
    50                  55                  60                  


Tyr Arg Ile Gly Val Phe Ala Gln Asn Leu Glu Val Ile Lys Asn Asp 
65                  70                  75                  80  


Pro Ser Phe Gly Val Thr Lys Phe Met Asp Met Thr Pro Gln Glu Phe 
                85                  90                  95      


Glu Gln Ser Tyr Leu Ser Leu Gln Leu Gln Gln Asn Phe Asn Ala Glu 
            100                 105                 110         


Lys Val Asp Gly Asp Phe Asn Gly Asp Ile Asp Trp Thr Gln Lys Gly 
        115                 120                 125             


Ala Val Thr Pro Val Lys Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala 
    130                 135                 140                 


Phe Ser Ala Ile Gly Ala Val Glu Ser Ala Leu Ile Leu Asn Gly Glu 
145                 150                 155                 160 


Asp Lys Asn Ile Asn Leu Ala Glu Gln Glu Leu Val Asp Cys Ala Thr 
                165                 170                 175     


Thr Pro Lys Tyr Glu Asn Glu Gly Cys Asn Gly Gly Trp Met Asp Ser 
            180                 185                 190         


Ala Phe Asp Tyr Ile Ile Asp Glu Lys Ile Ser Gln Thr Lys Asp Tyr 
        195                 200                 205             


Lys Tyr Thr Ala Arg Asp Gly Lys Cys Lys Asp Thr Ser Ser Phe Glu 
    210                 215                 220                 


Lys Lys Ser Ile Ser Gly Tyr Lys Asp Ile Pro Gln Gly Asp Cys Lys 
225                 230                 235                 240 


Ser Leu Leu Asn Ala Leu Ser Gln Gln Pro Val Ala Ile Ala Val Asp 
                245                 250                 255     


Ala Ser Ser Trp Gln Phe Tyr Asn Lys Gly Val Leu Ser Ser Cys Gly 
            260                 265                 270         


Ser Arg Leu Asn His Gly Val Leu Leu Thr Gly Tyr Val Asn Glu Thr 
        275                 280                 285             


Tyr Lys Val Lys Asn Ser Trp Gly Thr Ser Trp Gly Glu Lys Gly Phe 
    290                 295                 300                 


Ile Gln Leu Lys Ser Gly Asn Ser Cys Gly Leu Cys Asn Ala Ala Ser 
305                 310                 315                 320 


Tyr Pro Leu Ala 
                


<210>  6
<211>  320
<212>  PRT
<213>  Tetrahymena thermophila

<400>  6

Met Asn Lys Thr Leu Ile Leu Ala Leu Val Gly Val Leu Ala Leu Thr 
1               5                   10                  15      


Ala Thr Thr Leu Val Ala Phe His Asn His Ser His Asn Ile Arg Val 
            20                  25                  30          


Asp Gln Asp Pro Ala Thr Leu Phe Lys Gln Phe Lys Gln Thr Tyr Asn 
        35                  40                  45              


Lys Lys Tyr Ala Asp Pro Thr Phe Glu Thr Tyr Arg Phe Gly Val Phe 
    50                  55                  60                  


Thr Gln Asn Leu Glu Ile Val Lys Thr Asp Ser Thr Phe Gly Val Thr 
65                  70                  75                  80  


Gln Phe Met Asp Leu Thr Pro Ala Glu Phe Ala Gln Gln Phe Leu Thr 
                85                  90                  95      


Leu His Glu Lys Val Asn Ser Thr Glu Val Tyr Arg Ala Gln Gly Glu 
            100                 105                 110         


Ala Thr Glu Val Asp Trp Thr Ala Lys Gly Lys Val Thr Pro Val Lys 
        115                 120                 125             


Asn Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Thr Ile Gly Ala 
    130                 135                 140                 


Val Glu Ser Ala Leu Leu Ile Ala Gly Gln Gly Glu Gln Asn Thr Leu 
145                 150                 155                 160 


Asn Leu Ala Glu Gln Glu Leu Val Asp Cys Ala Lys Ser Pro Lys Tyr 
                165                 170                 175     


Asp Ser Glu Gly Cys Asn Gly Gly Trp Met Val Glu Gly Phe Lys Tyr 
            180                 185                 190         


Ile Ile Asp Asn Lys Ile Ser Gln Thr Ala Asn Tyr Pro Tyr Thr Ala 
        195                 200                 205             


Lys Asp Gly Lys Cys Lys Asp Thr Ser Ser Phe Lys Lys Phe Ser Ile 
    210                 215                 220                 


Ser Lys Tyr Ala Glu Ile Pro Gln Gly Asp Cys Asn Ser Leu Asn Ser 
225                 230                 235                 240 


Ala Leu Glu Gln Gly Pro Ile Ser Val Ala Val Asp Ala Thr Asn Phe 
                245                 250                 255     


Gln Phe Tyr Thr Ser Gly Val Phe Lys Asn Cys Lys Ala Asn Leu Asn 
            260                 265                 270         


His Gly Val Leu Leu Val Ala Asn Val Asp Ser Ser Leu Lys Ile Lys 
        275                 280                 285             


Asn Ser Trp Gly Pro Ser Trp Gly Glu Lys Gly Phe Ile Arg Leu Ala 
    290                 295                 300                 


Ala Gly Asn Thr Cys Gly Val Cys Asn Ala Ala Ser Tyr Pro Ile Val 
305                 310                 315                 320 


<210>  7
<211>  325
<212>  PRT
<213>  Tetrahymena thermophila

<400>  7

Met Arg Thr Gln Leu Leu Ile Ala Ala Ala Leu Gly Leu Thr Leu Leu 
1               5                   10                  15      


Gly Leu Thr Ser Tyr Leu Phe Leu His Lys Ser Thr Gln Val Gly Tyr 
            20                  25                  30          


Thr Asp Asp Gln Ile Asn Met Trp Lys Gly Phe Lys Lys Thr Tyr Asn 
        35                  40                  45              


Lys Lys Phe Ser Ser Glu Asp Ala Asp Gln Glu Ala Tyr Arg Met Asn 
    50                  55                  60                  


Val Phe Phe Asp Asn Val Glu Tyr Ala Ser Gln Asp Ser Thr Met Gly 
65                  70                  75                  80  


Ile Thr Lys Phe Met Asp Leu Thr Pro Val Glu Phe Ala Gln Leu Tyr 
                85                  90                  95      


Leu Asn Pro Ile Glu Asn Val Glu Gly Ser Ile Glu Thr Phe Gln Ala 
            100                 105                 110         


Ile Gln Ala Asn Gly Asp Ile Val Val Asp Trp Val Ala Lys Gly Ala 
        115                 120                 125             


Val Thr Pro Val Lys Asp Gln Gly Gly Cys Gly Gly Cys Trp Ser Phe 
    130                 135                 140                 


Ala Thr Thr Gly Gly Val Glu Gly Ala Asn Phe Val Tyr Lys Asn Val 
145                 150                 155                 160 


Leu Pro Asn Leu Ser Glu Gln Gln Leu Ile Asp Cys Asp Thr Gln Asn 
                165                 170                 175     


Ser Gly Cys Gly Gly Gly Leu Arg Asp Val Ala Leu Asn Tyr Val Lys 
            180                 185                 190         


Ala Thr Gly Leu Ala Thr Glu Gln Asp Tyr Pro Tyr Glu Ala Lys Asp 
        195                 200                 205             


Gly Lys Cys Arg Leu Glu Gly Lys Ser His Pro Trp Thr Val Ser Gly 
    210                 215                 220                 


Tyr Thr Ser Ile Lys Gln Cys Ala Asp Leu Val Thr Ala Ile Gln Lys 
225                 230                 235                 240 


Ala Pro Val Thr Val Gly Ile Asp Ala Ser Asn Leu Gln Phe Tyr Thr 
                245                 250                 255     


Gly Gly Ile Phe Ser Lys Cys Ala Thr Asn Ile Asn His Gly Val Leu 
            260                 265                 270         


Leu Val Gly Tyr Asp Ser Val Asn Gln Ser Trp Lys Val Lys Asn Ser 
        275                 280                 285             


Trp Gly Pro Asn Phe Gly Glu His Gly Tyr Phe Gln Leu Ser Ala Lys 
    290                 295                 300                 


Val Thr Gly Asp Gln Ile Ala Asn Thr Cys Gly Ile Cys Ser Arg Ala 
305                 310                 315                 320 


Tyr Ala Pro Tyr Ile 
                325 


<210>  8
<211>  272
<212>  PRT
<213>  Tetrahymena thermophila

<400>  8

Gln Ser Phe Thr Tyr Thr Gln Ser Leu Ala Gln Asp Leu Ala Gly Phe 
1               5                   10                  15      


Ser Leu Ala Ser Tyr Cys Asn Pro Lys Ser Ile Glu Gln Trp Asn Cys 
            20                  25                  30          


Gly Cys Ala Cys Asp Lys Asn Pro Gln Gly Leu Arg Asn Val Thr Ile 
        35                  40                  45              


Leu Phe Asn Ser Thr Leu Gln Ala Ser Gly Tyr Leu Gly Tyr Ser Thr 
    50                  55                  60                  


His His Asp Ala Ile Val Val Val Phe Arg Gly Thr Val Pro Trp Leu 
65                  70                  75                  80  


Ile Glu Asn Trp Ile Ala Asp Leu Asn Thr Phe Lys Thr Gln Tyr Pro 
                85                  90                  95      


Leu Cys Gln Asn Cys Tyr Val His Gln Gly Phe Tyr Asn Gln Phe Lys 
            100                 105                 110         


Gln Leu Lys Ser Gln Leu Val Thr Ser Phe Thr Ser Leu Arg Gln Leu 
        115                 120                 125             


Tyr Pro Asn Ala Lys Val Phe Val Thr Gly His Ser Leu Gly Ala Ala 
    130                 135                 140                 


Met Ser Ala His Ser Ile Pro Val Ile Tyr Gln Leu Asn Gly Asn Lys 
145                 150                 155                 160 


Pro Ile Asp Ala Phe Tyr Asn Tyr Gly Cys Pro Arg Val Gly Asp Gln 
                165                 170                 175     


Thr Tyr Ala Asn Trp Phe Asn Ser Gln Asn Phe Ala Leu Glu Tyr Gly 
            180                 185                 190         


Arg Ile Asn Asn Ala Ala Asp Pro Val Pro His Leu Pro Pro Leu Leu 
        195                 200                 205             


Tyr Pro Phe Ser Phe Phe His Tyr Asn His Glu Ile Phe Tyr Pro Ser 
    210                 215                 220                 


Phe Val Leu Phe Gly Asn Gln His Asn Gln Cys Gln Asn Ala Glu Thr 
225                 230                 235                 240 


Ile Phe Gly Ala Asp Gly Val Ile Ile Ala Ala Asn Val Leu Asp His 
                245                 250                 255     


Leu Thr Tyr Phe Gly Trp Asp Trp Ser Gly Ser Ile Leu Thr Cys Gln 
            260                 265                 270         


<210>  9
<211>  270
<212>  PRT
<213>  Tetrahymena thermophila

<400>  9

Phe Gln Tyr Asn Glu Thr Leu Ala Gln Asp Leu Ala Gly Phe Ser Leu 
1               5                   10                  15      


Ala Ser Tyr Cys Asn Pro Lys Tyr Leu Gln Gln Trp Asn Cys Gly Ser 
            20                  25                  30          


Ala Cys Lys Lys Asn Pro Asn Gly Leu Thr Asp Phe Ser Tyr Leu Tyr 
        35                  40                  45              


Asn Lys Thr Leu Lys Ala Ser Gly Tyr Ile Gly Tyr Ser Ala His His 
    50                  55                  60                  


Asp Ala Ile Ile Val Val Phe Arg Gly Thr Val Pro Trp Leu Ile Gln 
65                  70                  75                  80  


Asn Trp Ile Ala Asp Leu Asn Thr Ile Lys Ile Gln Tyr Pro Phe Cys 
                85                  90                  95      


Glu Asn Cys Tyr Val His Lys Gly Phe Tyr Lys Gln Phe Asn Gln Leu 
            100                 105                 110         


Lys Ser Gln Leu Ile Gln Ser Phe Thr Glu Ile Arg Gln Lys Tyr Pro 
        115                 120                 125             


Ser Ser Lys Ile Phe Val Thr Gly His Ser Leu Gly Ala Ala Met Ser 
    130                 135                 140                 


Phe His Ser Met Pro Ile Ile Phe Glu Leu Asn Gly Asn Lys Pro Ile 
145                 150                 155                 160 


Asp Ala Phe Tyr Asn Tyr Gly Ser Pro Arg Val Gly Asn Glu Ala Tyr 
                165                 170                 175     


Ala Thr Trp Phe Asn Leu Gln Asn Phe Ala Leu Gln Tyr Gly Arg Ile 
            180                 185                 190         


Asn Asn Ala Ala Asp Pro Val Pro His Leu Pro Pro Ile Leu Phe Pro 
        195                 200                 205             


Phe Gln Phe Tyr His Thr Asn His Glu Ile Phe Tyr Thr Ser Phe Ile 
    210                 215                 220                 


Glu Asp Gly Asn Lys Tyr Glu Gln Cys Leu Asp Ala Glu His Lys Leu 
225                 230                 235                 240 


Cys Ala Asn Ser Lys Ile Ile Ala Ala Ser Val Arg Asp His Leu Ser 
                245                 250                 255     


Tyr Phe Gly Trp Asn Trp Ala Thr Ser Ile Leu Thr Cys Gln 
            260                 265                 270 


<210>  10
<211>  289
<212>  PRT
<213>  Tetrahymena thermophila

<400>  10

Val Tyr Leu Leu Asn Lys Ser Ser Ser Asp Val Gln Glu Ser Gln Leu 
1               5                   10                  15      


Thr Phe Pro Tyr Asp Glu Asn Leu Ala Glu Asn Leu Ala Gly Phe Ser 
            20                  25                  30          


Met Ala Ser Tyr Cys Lys Ala Ser Lys Ile Glu Asn Trp Asn Cys Gly 
        35                  40                  45              


Ala Ser Cys Lys Lys Asn Pro Glu Gly Leu Gln Asp Val Tyr Ile Met 
    50                  55                  60                  


Lys Asn Lys Thr Met Asn Ala Ala Gly Phe Leu Ala Tyr Ser Pro Ala 
65                  70                  75                  80  


His Asp Ala Ile Val Val Val Phe Arg Gly Thr Val Pro Trp Leu Ile 
                85                  90                  95      


Lys Asn Trp Ile Ser Asp Ile Asn Thr Val Lys Thr Lys Tyr Ser Arg 
            100                 105                 110         


Cys Glu Lys Cys Tyr Val His Leu Gly Phe Phe Asn Ala Phe Lys Glu 
        115                 120                 125             


Leu Gln Asp Gln Ile Leu Thr Glu Phe Pro Lys Leu Lys Ala Lys Tyr 
    130                 135                 140                 


Pro Tyr Ser Lys Asn Ile Asn Tyr Ser Lys Leu Asn Arg Arg His Ser 
145                 150                 155                 160 


Leu Gly Ala Ala Met Ser Thr His Ala Val Pro Val Ile Tyr Glu Leu 
                165                 170                 175     


Asn Gly Asn Lys Pro Ile Asp Ala Phe Tyr Asn Phe Gly Ser Pro Arg 
            180                 185                 190         


Val Gly Asp Glu Asn Tyr His Gln Trp Phe Asp Ser Gln Asn Phe Thr 
        195                 200                 205             


Leu Gln Tyr Gly Arg Ile Asn His Arg Ala Asp Pro Val Pro His Leu 
    210                 215                 220                 


Pro Pro Asn Tyr Ser Pro Phe Thr Phe Thr His Ile Asp His Glu Val 
225                 230                 235                 240 


Phe Tyr Gln Thr Phe Lys Lys Pro Tyr Thr Gln Cys Ile Glu Thr Glu 
                245                 250                 255     


Ser Leu Glu Cys Ala Asp Gly Ile Lys Ile Pro Leu Asp Ile Pro Asp 
            260                 265                 270         


His Leu Ser Tyr Phe Gly Trp Asp Trp Ala Thr Asp Ile Leu Ala Cys 
        275                 280                 285             


Gln 
    


<210>  11
<211>  467
<212>  PRT
<213>  Tetrahymena thermophila

<400>  11

Lys Thr Ala Gln Glu Trp Lys Thr Arg Asn Ile Tyr Gln Ile Ile Thr 
1               5                   10                  15      


Asp Arg Phe Ala Leu Gly Asp Gly Ser Lys Pro Tyr Cys Asp Leu Asn 
            20                  25                  30          


Lys Gln Pro Tyr Tyr Cys Gly Gly Asn Phe Lys Gly Ile Glu Asn Asn 
        35                  40                  45              


Leu Asp Tyr Ile Gln Gly Met Gly Phe Asn Ala Ile Trp Ile Ser Pro 
    50                  55                  60                  


Val Pro Asp Asn Tyr Pro Asn Gln Phe His Gly Tyr Ala Ala Lys Asn 
65                  70                  75                  80  


Met Thr Glu Ile Asn Ser His Phe Gly Gly Ala Asp Gly Leu Lys Ser 
                85                  90                  95      


Leu Ile Asp Ala Cys His Lys Arg Asp Ile Trp Val Met Ile Asp Val 
            100                 105                 110         


Val Ala Asn His Met Gly Asn Thr Asp Gln Asn Tyr Ser Glu Asn Ile 
        115                 120                 125             


Pro Phe Asn Ser Pro Asp His Tyr His Ser Tyr Cys Ile Ile Ser Asp 
    130                 135                 140                 


Ser Asp Phe Ala Thr Lys Asn Met Tyr Asn Ile Gln His Cys Arg Leu 
145                 150                 155                 160 


Ala Gly Leu Ala Asp Leu Asn Gln Glu Asn Ser Tyr Val Ser Asn Tyr 
                165                 170                 175     


Leu Val Asn Trp Ile Lys Asp Leu Val Gln Thr Tyr Asn Val Asp Gly 
            180                 185                 190         


Ile Arg Ile Asp Thr Val Pro Glu Val His Pro Asp Phe Trp Lys Gln 
        195                 200                 205             


Tyr Thr Thr Ser Ala Gly Val Phe Ala Thr Gly Glu Val Phe Asp Gly 
    210                 215                 220                 


Asp Phe Gly Tyr Val Ala Ser Tyr Ile Pro Ser Val Gly Ser Val Leu 
225                 230                 235                 240 


Asn Tyr Pro Trp Tyr Phe Asn Met Arg Asp Ile Phe Val Asn Gln Lys 
                245                 250                 255     


Asp Met Trp Gly Val Arg Thr Tyr Tyr Gln Asn Trp Ala Asn Gln His 
            260                 265                 270         


Ala Asp Leu Ser Ile Leu Thr Pro Phe Val Asp Asn His Asp Asn Pro 
        275                 280                 285             


Arg Phe Leu Ser Asp Gln Val Phe Asn Asn Gly Lys Asp Arg Asn Thr 
    290                 295                 300                 


Arg Ile Gln Leu Leu Lys Gly Tyr Thr Thr Phe Thr Leu Thr Ser Ile 
305                 310                 315                 320 


Gly Ile Pro Ile Leu Tyr Tyr Gly Thr Glu Gln Tyr Phe Ser Gly Asn 
                325                 330                 335     


Thr Asp Pro Tyr Asp Arg Glu Pro Leu Trp Asn Ser Leu Asn Thr Asn 
            340                 345                 350         


Ser Asp Met Tyr Lys Tyr Val Gln Ser Ile Leu Tyr Ala Lys Asn Ile 
        355                 360                 365             


Thr Asn Ala Gly Leu Gln Gly Gln Thr Glu Ala Tyr Cys Asp Gln Asp 
    370                 375                 380                 


Leu Tyr Ala Phe Phe Arg Gly Lys Leu Phe Val Gly Val Thr Ser Lys 
385                 390                 395                 400 


Phe Asn Gln Val Thr Arg Gln Ile Val Thr His Pro Phe Ser Asn Gly 
                405                 410                 415     


Glu Val Ile Cys Asn Ile Phe Tyr Pro Thr Gln Asp Cys Leu Thr Ile 
            420                 425                 430         


Thr Asn Asn Ser Phe Asn Leu Val Leu Ile Gly Gly Glu Ala Lys Ile 
        435                 440                 445             


Phe Val Pro Lys Ser Leu Leu Gln Lys Ser Ser Gln Phe Leu Arg Ser 
    450                 455                 460                 


Ala Ser Ser 
465         


<210>  12
<211>  303
<212>  PRT
<213>  Tetrahymena thermophila

<400>  12

Gly Ile Tyr Tyr Gln Asn His Gln Ala Ser Gln Leu Glu Lys Ser Phe 
1               5                   10                  15      


Lys Arg Asn Thr Ile Leu Glu Gln Trp Asn Glu Phe Lys Gln Lys Phe 
            20                  25                  30          


Gly Lys Lys Tyr Ala Asp Gln Glu Phe Glu Arg Tyr Arg Ile Gly Val 
        35                  40                  45              


Phe Ala Gln Asn Leu Glu Val Ile Lys Asn Asp Pro Ser Phe Gly Val 
    50                  55                  60                  


Thr Lys Phe Met Asp Met Thr Pro Gln Glu Phe Glu Gln Ser Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Leu Gln Gln Asn Phe Asn Ala Glu Lys Val Asp Gly Asp 
                85                  90                  95      


Phe Asn Gly Asp Ile Asp Trp Thr Gln Lys Gly Ala Val Thr Pro Val 
            100                 105                 110         


Lys Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Ala Ile Gly 
        115                 120                 125             


Ala Val Glu Ser Ala Leu Ile Leu Asn Gly Glu Asp Lys Asn Ile Asn 
    130                 135                 140                 


Leu Ala Glu Gln Glu Leu Val Asp Cys Ala Thr Thr Pro Lys Tyr Glu 
145                 150                 155                 160 


Asn Glu Gly Cys Asn Gly Gly Trp Met Asp Ser Ala Phe Asp Tyr Ile 
                165                 170                 175     


Ile Asp Glu Lys Ile Ser Gln Thr Lys Asp Tyr Lys Tyr Thr Ala Arg 
            180                 185                 190         


Asp Gly Lys Cys Lys Asp Thr Ser Ser Phe Glu Lys Lys Ser Ile Ser 
        195                 200                 205             


Gly Tyr Lys Asp Ile Pro Gln Gly Asp Cys Lys Ser Leu Leu Asn Ala 
    210                 215                 220                 


Leu Ser Gln Gln Pro Val Ala Ile Ala Val Asp Ala Ser Ser Trp Gln 
225                 230                 235                 240 


Phe Tyr Asn Lys Gly Val Leu Ser Ser Cys Gly Ser Arg Leu Asn His 
                245                 250                 255     


Gly Val Leu Leu Thr Gly Tyr Val Asn Glu Thr Tyr Lys Val Lys Asn 
            260                 265                 270         


Ser Trp Gly Thr Ser Trp Gly Glu Lys Gly Phe Ile Gln Leu Lys Ser 
        275                 280                 285             


Gly Asn Ser Cys Gly Leu Cys Asn Ala Ala Ser Tyr Pro Leu Ala 
    290                 295                 300             


<210>  13
<211>  298
<212>  PRT
<213>  Tetrahymena thermophila

<400>  13

Phe His Asn His Ser His Asn Ile Arg Val Asp Gln Asp Pro Ala Thr 
1               5                   10                  15      


Leu Phe Lys Gln Phe Lys Gln Thr Tyr Asn Lys Lys Tyr Ala Asp Pro 
            20                  25                  30          


Thr Phe Glu Thr Tyr Arg Phe Gly Val Phe Thr Gln Asn Leu Glu Ile 
        35                  40                  45              


Val Lys Thr Asp Ser Thr Phe Gly Val Thr Gln Phe Met Asp Leu Thr 
    50                  55                  60                  


Pro Ala Glu Phe Ala Gln Gln Phe Leu Thr Leu His Glu Lys Val Asn 
65                  70                  75                  80  


Ser Thr Glu Val Tyr Arg Ala Gln Gly Glu Ala Thr Glu Val Asp Trp 
                85                  90                  95      


Thr Ala Lys Gly Lys Val Thr Pro Val Lys Asn Gln Gly Ser Cys Gly 
            100                 105                 110         


Ser Cys Trp Ala Phe Ser Thr Ile Gly Ala Val Glu Ser Ala Leu Leu 
        115                 120                 125             


Ile Ala Gly Gln Gly Glu Gln Asn Thr Leu Asn Leu Ala Glu Gln Glu 
    130                 135                 140                 


Leu Val Asp Cys Ala Lys Ser Pro Lys Tyr Asp Ser Glu Gly Cys Asn 
145                 150                 155                 160 


Gly Gly Trp Met Val Glu Gly Phe Lys Tyr Ile Ile Asp Asn Lys Ile 
                165                 170                 175     


Ser Gln Thr Ala Asn Tyr Pro Tyr Thr Ala Lys Asp Gly Lys Cys Lys 
            180                 185                 190         


Asp Thr Ser Ser Phe Lys Lys Phe Ser Ile Ser Lys Tyr Ala Glu Ile 
        195                 200                 205             


Pro Gln Gly Asp Cys Asn Ser Leu Asn Ser Ala Leu Glu Gln Gly Pro 
    210                 215                 220                 


Ile Ser Val Ala Val Asp Ala Thr Asn Phe Gln Phe Tyr Thr Ser Gly 
225                 230                 235                 240 


Val Phe Lys Asn Cys Lys Ala Asn Leu Asn His Gly Val Leu Leu Val 
                245                 250                 255     


Ala Asn Val Asp Ser Ser Leu Lys Ile Lys Asn Ser Trp Gly Pro Ser 
            260                 265                 270         


Trp Gly Glu Lys Gly Phe Ile Arg Leu Ala Ala Gly Asn Thr Cys Gly 
        275                 280                 285             


Val Cys Asn Ala Ala Ser Tyr Pro Ile Val 
    290                 295             


<210>  14
<211>  301
<212>  PRT
<213>  Tetrahymena thermophila

<400>  14

His Lys Ser Thr Gln Val Gly Tyr Thr Asp Asp Gln Ile Asn Met Trp 
1               5                   10                  15      


Lys Gly Phe Lys Lys Thr Tyr Asn Lys Lys Phe Ser Ser Glu Asp Ala 
            20                  25                  30          


Asp Gln Glu Ala Tyr Arg Met Asn Val Phe Phe Asp Asn Val Glu Tyr 
        35                  40                  45              


Ala Ser Gln Asp Ser Thr Met Gly Ile Thr Lys Phe Met Asp Leu Thr 
    50                  55                  60                  


Pro Val Glu Phe Ala Gln Leu Tyr Leu Asn Pro Ile Glu Asn Val Glu 
65                  70                  75                  80  


Gly Ser Ile Glu Thr Phe Gln Ala Ile Gln Ala Asn Gly Asp Ile Val 
                85                  90                  95      


Val Asp Trp Val Ala Lys Gly Ala Val Thr Pro Val Lys Asp Gln Gly 
            100                 105                 110         


Gly Cys Gly Gly Cys Trp Ser Phe Ala Thr Thr Gly Gly Val Glu Gly 
        115                 120                 125             


Ala Asn Phe Val Tyr Lys Asn Val Leu Pro Asn Leu Ser Glu Gln Gln 
    130                 135                 140                 


Leu Ile Asp Cys Asp Thr Gln Asn Ser Gly Cys Gly Gly Gly Leu Arg 
145                 150                 155                 160 


Asp Val Ala Leu Asn Tyr Val Lys Ala Thr Gly Leu Ala Thr Glu Gln 
                165                 170                 175     


Asp Tyr Pro Tyr Glu Ala Lys Asp Gly Lys Cys Arg Leu Glu Gly Lys 
            180                 185                 190         


Ser His Pro Trp Thr Val Ser Gly Tyr Thr Ser Ile Lys Gln Cys Ala 
        195                 200                 205             


Asp Leu Val Thr Ala Ile Gln Lys Ala Pro Val Thr Val Gly Ile Asp 
    210                 215                 220                 


Ala Ser Asn Leu Gln Phe Tyr Thr Gly Gly Ile Phe Ser Lys Cys Ala 
225                 230                 235                 240 


Thr Asn Ile Asn His Gly Val Leu Leu Val Gly Tyr Asp Ser Val Asn 
                245                 250                 255     


Gln Ser Trp Lys Val Lys Asn Ser Trp Gly Pro Asn Phe Gly Glu His 
            260                 265                 270         


Gly Tyr Phe Gln Leu Ser Ala Lys Val Thr Gly Asp Gln Ile Ala Asn 
        275                 280                 285             


Thr Cys Gly Ile Cys Ser Arg Ala Tyr Ala Pro Tyr Ile 
    290                 295                 300     


<210>  15
<211>  207
<212>  PRT
<213>  Tetrahymena thermophila

<400>  15

Phe Asn Gly Asp Ile Asp Trp Thr Gln Lys Gly Ala Val Thr Pro Val 
1               5                   10                  15      


Lys Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Ala Ile Gly 
            20                  25                  30          


Ala Val Glu Ser Ala Leu Ile Leu Asn Gly Glu Asp Lys Asn Ile Asn 
        35                  40                  45              


Leu Ala Glu Gln Glu Leu Val Asp Cys Ala Thr Thr Pro Lys Tyr Glu 
    50                  55                  60                  


Asn Glu Gly Cys Asn Gly Gly Trp Met Asp Ser Ala Phe Asp Tyr Ile 
65                  70                  75                  80  


Ile Asp Glu Lys Ile Ser Gln Thr Lys Asp Tyr Lys Tyr Thr Ala Arg 
                85                  90                  95      


Asp Gly Lys Cys Lys Asp Thr Ser Ser Phe Glu Lys Lys Ser Ile Ser 
            100                 105                 110         


Gly Tyr Lys Asp Ile Pro Gln Gly Asp Cys Lys Ser Leu Leu Asn Ala 
        115                 120                 125             


Leu Ser Gln Gln Pro Val Ala Ile Ala Val Asp Ala Ser Ser Trp Gln 
    130                 135                 140                 


Phe Tyr Asn Lys Gly Val Leu Ser Ser Cys Gly Ser Arg Leu Asn His 
145                 150                 155                 160 


Gly Val Leu Leu Thr Gly Tyr Val Asn Glu Thr Tyr Lys Val Lys Asn 
                165                 170                 175     


Ser Trp Gly Thr Ser Trp Gly Glu Lys Gly Phe Ile Gln Leu Lys Ser 
            180                 185                 190         


Gly Asn Ser Cys Gly Leu Cys Asn Ala Ala Ser Tyr Pro Leu Ala 
        195                 200                 205         


<210>  16
<211>  209
<212>  PRT
<213>  Tetrahymena thermophila

<400>  16

Glu Ala Thr Glu Val Asp Trp Thr Ala Lys Gly Lys Val Thr Pro Val 
1               5                   10                  15      


Lys Asn Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Thr Ile Gly 
            20                  25                  30          


Ala Val Glu Ser Ala Leu Leu Ile Ala Gly Gln Gly Glu Gln Asn Thr 
        35                  40                  45              


Leu Asn Leu Ala Glu Gln Glu Leu Val Asp Cys Ala Lys Ser Pro Lys 
    50                  55                  60                  


Tyr Asp Ser Glu Gly Cys Asn Gly Gly Trp Met Val Glu Gly Phe Lys 
65                  70                  75                  80  


Tyr Ile Ile Asp Asn Lys Ile Ser Gln Thr Ala Asn Tyr Pro Tyr Thr 
                85                  90                  95      


Ala Lys Asp Gly Lys Cys Lys Asp Thr Ser Ser Phe Lys Lys Phe Ser 
            100                 105                 110         


Ile Ser Lys Tyr Ala Glu Ile Pro Gln Gly Asp Cys Asn Ser Leu Asn 
        115                 120                 125             


Ser Ala Leu Glu Gln Gly Pro Ile Ser Val Ala Val Asp Ala Thr Asn 
    130                 135                 140                 


Phe Gln Phe Tyr Thr Ser Gly Val Phe Lys Asn Cys Lys Ala Asn Leu 
145                 150                 155                 160 


Asn His Gly Val Leu Leu Val Ala Asn Val Asp Ser Ser Leu Lys Ile 
                165                 170                 175     


Lys Asn Ser Trp Gly Pro Ser Trp Gly Glu Lys Gly Phe Ile Arg Leu 
            180                 185                 190         


Ala Ala Gly Asn Thr Cys Gly Val Cys Asn Ala Ala Ser Tyr Pro Ile 
        195                 200                 205             


Val 
    


<210>  17
<211>  209
<212>  PRT
<213>  Tetrahymena thermophila

<400>  17

Gly Asp Ile Val Val Asp Trp Val Ala Lys Gly Ala Val Thr Pro Val 
1               5                   10                  15      


Lys Asp Gln Gly Gly Cys Gly Gly Cys Trp Ser Phe Ala Thr Thr Gly 
            20                  25                  30          


Gly Val Glu Gly Ala Asn Phe Val Tyr Lys Asn Val Leu Pro Asn Leu 
        35                  40                  45              


Ser Glu Gln Gln Leu Ile Asp Cys Asp Thr Gln Asn Ser Gly Cys Gly 
    50                  55                  60                  


Gly Gly Leu Arg Asp Val Ala Leu Asn Tyr Val Lys Ala Thr Gly Leu 
65                  70                  75                  80  


Ala Thr Glu Gln Asp Tyr Pro Tyr Glu Ala Lys Asp Gly Lys Cys Arg 
                85                  90                  95      


Leu Glu Gly Lys Ser His Pro Trp Thr Val Ser Gly Tyr Thr Ser Ile 
            100                 105                 110         


Lys Gln Cys Ala Asp Leu Val Thr Ala Ile Gln Lys Ala Pro Val Thr 
        115                 120                 125             


Val Gly Ile Asp Ala Ser Asn Leu Gln Phe Tyr Thr Gly Gly Ile Phe 
    130                 135                 140                 


Ser Lys Cys Ala Thr Asn Ile Asn His Gly Val Leu Leu Val Gly Tyr 
145                 150                 155                 160 


Asp Ser Val Asn Gln Ser Trp Lys Val Lys Asn Ser Trp Gly Pro Asn 
                165                 170                 175     


Phe Gly Glu His Gly Tyr Phe Gln Leu Ser Ala Lys Val Thr Gly Asp 
            180                 185                 190         


Gln Ile Ala Asn Thr Cys Gly Ile Cys Ser Arg Ala Tyr Ala Pro Tyr 
        195                 200                 205             


Ile 
    


