               SEQUENCE LISTING

<110> Berlin Cures GmbH

<120> APTAMERS FOR USE IN THE TREATMENT OF CORONAVIRIDAE INFECTIONS

<130> BLC73438PCT1

<150> PCT/EP2021/059328
<151> 2021-04-09

<160> 11

<170> BiSSAP 1.3.6

<210> 1
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> Aptamer BC007

<400> 1
ggttggtgtg gttgg                                                     15


<210> 2
<211> 223
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus 2


<220> 
<223> Receptor-binding domain (RBD) of S1 Subunit of Spike protein of
      SARS-CoV-2

<400> 2
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             

<210> 3
<211> 222
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus


<220> 
<223> Receptor-binding domain of S1 subunit of Spike protein of
      SARS-CoV

<400> 3
Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          
Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              
Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  
Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  
Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      
Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         
Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             
Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 
Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     
Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         
Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             
Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
    210                 215                 220         

<210> 4
<211> 240
<212> PRT
<213> Middle East respiratory syndrome-related coronavirus


<220> 
<223> Receptor-binding domain of S1 subunit of Spike protein of
      MERS-CoV

<400> 4
Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      
Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          
Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              
Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  
Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  
Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      
Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         
Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             
Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 
Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 
Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     
Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         
Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             
Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 
Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 



<210> 5
<211> 6
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus 2


<220> 
<223> Amino acids 135-140 of SEQ ID NO: 1

<400> 5
Tyr Arg Leu Phe Arg Lys 
1               5       

<210> 6
<211> 68
<212> DNA
<213> Artificial Sequence


<220> 
<223> Anti-Influenza Aptamer A22

<400> 6
aattaaccct cactaaaggg ctgagtctca aaaccgcaat acactggttg tatggtcgaa     60

taagttaa                                                              68


<210> 7
<211> 26
<212> DNA
<213> Artificial Sequence


<220> 
<223> Aptamer AS 1411

<400> 7
ggtggtggtg gttgtggtgg tggtgg                                         26


<210> 8
<211> 932
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus 2


<220> 
<223> RNA dependent RNA polymerase from SARS-CoV-2 virus

<400> 8
Ser Ala Asp Ala Gln Ser Phe Leu Asn Arg Val Cys Gly Val Ser Ala 
1               5                   10                  15      
Ala Arg Leu Thr Pro Cys Gly Thr Gly Thr Ser Thr Asp Val Val Tyr 
            20                  25                  30          
Arg Ala Phe Asp Ile Tyr Asn Asp Lys Val Ala Gly Phe Ala Lys Phe 
        35                  40                  45              
Leu Lys Thr Asn Cys Cys Arg Phe Gln Glu Lys Asp Glu Asp Asp Asn 
    50                  55                  60                  
Leu Ile Asp Ser Tyr Phe Val Val Lys Arg His Thr Phe Ser Asn Tyr 
65                  70                  75                  80  
Gln His Glu Glu Thr Ile Tyr Asn Leu Leu Lys Asp Cys Pro Ala Val 
                85                  90                  95      
Ala Lys His Asp Phe Phe Lys Phe Arg Ile Asp Gly Asp Met Val Pro 
            100                 105                 110         
His Ile Ser Arg Gln Arg Leu Thr Lys Tyr Thr Met Ala Asp Leu Val 
        115                 120                 125             
Tyr Ala Leu Arg His Phe Asp Glu Gly Asn Cys Asp Thr Leu Lys Glu 
    130                 135                 140                 
Ile Leu Val Thr Tyr Asn Cys Cys Asp Asp Asp Tyr Phe Asn Lys Lys 
145                 150                 155                 160 
Asp Trp Tyr Asp Phe Val Glu Asn Pro Asp Ile Leu Arg Val Tyr Ala 
                165                 170                 175     
Asn Leu Gly Glu Arg Val Arg Gln Ala Leu Leu Lys Thr Val Gln Phe 
            180                 185                 190         
Cys Asp Ala Met Arg Asn Ala Gly Ile Val Gly Val Leu Thr Leu Asp 
        195                 200                 205             
Asn Gln Asp Leu Asn Gly Asn Trp Tyr Asp Phe Gly Asp Phe Ile Gln 
    210                 215                 220                 
Thr Thr Pro Gly Ser Gly Val Pro Val Val Asp Ser Tyr Tyr Ser Leu 
225                 230                 235                 240 
Leu Met Pro Ile Leu Thr Leu Thr Arg Ala Leu Thr Ala Glu Ser His 
                245                 250                 255     
Val Asp Thr Asp Leu Thr Lys Pro Tyr Ile Lys Trp Asp Leu Leu Lys 
            260                 265                 270         
Tyr Asp Phe Thr Glu Glu Arg Leu Lys Leu Phe Asp Arg Tyr Phe Lys 
        275                 280                 285             
Tyr Trp Asp Gln Thr Tyr His Pro Asn Cys Val Asn Cys Leu Asp Asp 
    290                 295                 300                 
Arg Cys Ile Leu His Cys Ala Asn Phe Asn Val Leu Phe Ser Thr Val 
305                 310                 315                 320 
Phe Pro Pro Thr Ser Phe Gly Pro Leu Val Arg Lys Ile Phe Val Asp 
                325                 330                 335     
Gly Val Pro Phe Val Val Ser Thr Gly Tyr His Phe Arg Glu Leu Gly 
            340                 345                 350         
Val Val His Asn Gln Asp Val Asn Leu His Ser Ser Arg Leu Ser Phe 
        355                 360                 365             
Lys Glu Leu Leu Val Tyr Ala Ala Asp Pro Ala Met His Ala Ala Ser 
    370                 375                 380                 
Gly Asn Leu Leu Leu Asp Lys Arg Thr Thr Cys Phe Ser Val Ala Ala 
385                 390                 395                 400 
Leu Thr Asn Asn Val Ala Phe Gln Thr Val Lys Pro Gly Asn Phe Asn 
                405                 410                 415     
Lys Asp Phe Tyr Asp Phe Ala Val Ser Lys Gly Phe Phe Lys Glu Gly 
            420                 425                 430         
Ser Ser Val Glu Leu Lys His Phe Phe Phe Ala Gln Asp Gly Asn Ala 
        435                 440                 445             
Ala Ile Ser Asp Tyr Asp Tyr Tyr Arg Tyr Asn Leu Pro Thr Met Cys 
    450                 455                 460                 
Asp Ile Arg Gln Leu Leu Phe Val Val Glu Val Val Asp Lys Tyr Phe 
465                 470                 475                 480 
Asp Cys Tyr Asp Gly Gly Cys Ile Asn Ala Asn Gln Val Ile Val Asn 
                485                 490                 495     
Asn Leu Asp Lys Ser Ala Gly Phe Pro Phe Asn Lys Trp Gly Lys Ala 
            500                 505                 510         
Arg Leu Tyr Tyr Asp Ser Met Ser Tyr Glu Asp Gln Asp Ala Leu Phe 
        515                 520                 525             
Ala Tyr Thr Lys Arg Asn Val Ile Pro Thr Ile Thr Gln Met Asn Leu 
    530                 535                 540                 
Lys Tyr Ala Ile Ser Ala Lys Asn Arg Ala Arg Thr Val Ala Gly Val 
545                 550                 555                 560 
Ser Ile Cys Ser Thr Met Thr Asn Arg Gln Phe His Gln Lys Leu Leu 
                565                 570                 575     
Lys Ser Ile Ala Ala Thr Arg Gly Ala Thr Val Val Ile Gly Thr Ser 
            580                 585                 590         
Lys Phe Tyr Gly Gly Trp His Asn Met Leu Lys Thr Val Tyr Ser Asp 
        595                 600                 605             
Val Glu Asn Pro His Leu Met Gly Trp Asp Tyr Pro Lys Cys Asp Arg 
    610                 615                 620                 
Ala Met Pro Asn Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg 
625                 630                 635                 640 
Lys His Thr Thr Cys Cys Ser Leu Ser His Arg Phe Tyr Arg Leu Ala 
                645                 650                 655     
Asn Glu Cys Ala Gln Val Leu Ser Glu Met Val Met Cys Gly Gly Ser 
            660                 665                 670         
Leu Tyr Val Lys Pro Gly Gly Thr Ser Ser Gly Asp Ala Thr Thr Ala 
        675                 680                 685             
Tyr Ala Asn Ser Val Phe Asn Ile Cys Gln Ala Val Thr Ala Asn Val 
    690                 695                 700                 
Asn Ala Leu Leu Ser Thr Asp Gly Asn Lys Ile Ala Asp Lys Tyr Val 
705                 710                 715                 720 
Arg Asn Leu Gln His Arg Leu Tyr Glu Cys Leu Tyr Arg Asn Arg Asp 
                725                 730                 735     
Val Asp Thr Asp Phe Val Asn Glu Phe Tyr Ala Tyr Leu Arg Lys His 
            740                 745                 750         
Phe Ser Met Met Ile Leu Ser Asp Asp Ala Val Val Cys Phe Asn Ser 
        755                 760                 765             
Thr Tyr Ala Ser Gln Gly Leu Val Ala Ser Ile Lys Asn Phe Lys Ser 
    770                 775                 780                 
Val Leu Tyr Tyr Gln Asn Asn Val Phe Met Ser Glu Ala Lys Cys Trp 
785                 790                 795                 800 
Thr Glu Thr Asp Leu Thr Lys Gly Pro His Glu Phe Cys Ser Gln His 
                805                 810                 815     
Thr Met Leu Val Lys Gln Gly Asp Asp Tyr Val Tyr Leu Pro Tyr Pro 
            820                 825                 830         
Asp Pro Ser Arg Ile Leu Gly Ala Gly Cys Phe Val Asp Asp Ile Val 
        835                 840                 845             
Lys Thr Asp Gly Thr Leu Met Ile Glu Arg Phe Val Ser Leu Ala Ile 
    850                 855                 860                 
Asp Ala Tyr Pro Leu Thr Lys His Pro Asn Gln Glu Tyr Ala Asp Val 
865                 870                 875                 880 
Phe His Leu Tyr Leu Gln Tyr Ile Arg Lys Leu His Asp Glu Leu Thr 
                885                 890                 895     
Gly His Met Leu Asp Met Tyr Ser Val Met Leu Thr Asn Asp Asn Thr 
            900                 905                 910         
Ser Arg Tyr Trp Glu Pro Glu Phe Tyr Glu Ala Met Tyr Thr Pro His 
        915                 920                 925             
Thr Val Leu Gln 
    930         

<210> 9
<211> 7
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus 2


<220> 
<223> Peptide LYRNRDV (aa 731-737 of SEQ ID NO: 8)

<400> 9
Leu Tyr Arg Asn Arg Asp Val 
1               5           

<210> 10
<211> 8
<212> PRT
<213> Severe acute respiratory syndrome-related coronavirus 2


<220> 
<223> Peptide HRFYRLAN (aa 650-657 of SEQ ID NO: 8)

<400> 10
His Arg Phe Tyr Arg Leu Ala Asn 
1               5               

<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Control peptide NRKRISN

<400> 11
Asn Arg Lys Arg Ile Ser Asn 
1               5           

