                         SEQUENCE LISTING

<110>  Pieris Pharmaceuticals GmbH
 
<120>  Novel lipocalin muteins specific for connective tissue growth 
       factor (CTGF)

<130>  P065 PCT

<150>  EP 21167385.0
<151>  2021-04-08

<150>  EP 21192311.5
<151>  2021-08-20

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  178
<212>  PRT
<213>  human

<400>  1

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  2
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  2

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  3
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  3

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Arg Ala Gly Asn Asn Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr His Val His Phe Met Thr Lys Lys Cys Arg Tyr Ile Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Met Thr Ser Pro Leu Val Arg Ile Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Asn Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  4
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  4

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Arg Ala Gly Asn Asn Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr His Val His Phe Met Thr Lys Lys Cys Arg Tyr Ile Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Met Thr Ser Pro Leu Val Arg Ile Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Asn Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  5
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  5

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Lys Ala Gly Asn Ala Leu Arg Glu Asp Lys Glu Pro Pro 
        35                  40                  45              


Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asp 
    50                  55                  60                  


Val Thr His Val His Phe Leu Thr Lys Lys Cys Lys Tyr Leu Ile Asp 
65                  70                  75                  80  


Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ile Gly Ala Ile 
                85                  90                  95      


Lys Ser Gly Pro Gly Leu Thr Ser Pro Leu Val Arg Val Val Ser Thr 
            100                 105                 110         


Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Ser Gln Asn 
        115                 120                 125             


Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr 
    130                 135                 140                 


Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu 
145                 150                 155                 160 


Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp 
                165                 170                 175     


Gly 
    


<210>  6
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  6

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Arg Ala Gly Asn Asn Gln Leu Arg Glu Asp Lys Ser Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr His Val His Phe Ser Thr Lys Lys Cys Arg Tyr Ile Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Leu Thr Ser Pro Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  7
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  7

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Tyr Gly Leu Arg Thr Asp Lys Arg Pro 
        35                  40                  45              


Ser Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Gln Glu Arg Cys His Tyr Thr Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Thr Gly Ser 
                85                  90                  95      


Ile Lys Ser Arg Pro Gly Gln Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  8
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  8

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Tyr Gly Leu Arg Thr Asp Lys Arg Pro 
        35                  40                  45              


Ser Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Gln Glu Arg Cys His Tyr Thr Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ser Gly Asn 
                85                  90                  95      


Ile Gly Asn Tyr Pro Gly Ser Tyr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ser Val Ile Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Ala Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  9
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  9

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Lys Ile Leu Arg Ile Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Arg Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  10
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  10

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Trp Lys Ser Val Ala Gly 
        115                 120                 125             


Thr Arg Glu Ser Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  11
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  11

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ser 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  12
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  12

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Asn Lys Ser Cys Val Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Thr Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  13
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  13

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Asn Lys Ser Cys Val Tyr Thr Ser 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Thr Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  14
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  14

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ile Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Arg Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  15
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  15

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Tyr 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  16
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  16

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Thr Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Val Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  17
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  17

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Thr Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Val Tyr Thr Ser 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  18
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  18

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Ile Ala Gly Asn Ala Ile Leu Arg Asp Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Asn Lys Ser Cys Ile Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr His Gly Asn 
                85                  90                  95      


Ile Lys Ser His Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  19
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  19

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe His Lys Ala Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Ser Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  20
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  20

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Ala Lys Ala Val Gln Leu 
        115                 120                 125             


Asn Arg Glu His Phe Phe Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  21
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  21

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Ala Val Arg Gly 
        115                 120                 125             


Ala Arg Glu Ser Phe Asn Ile Ala Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  22
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  22

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Ile Ala Gly Asn Ala Ile Leu Arg Val Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Val Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  23
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  23

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Ala Ile Leu Arg Pro Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ser Gly Gln 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  24
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  24

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Ala Ile Leu Arg Thr Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  25
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  25

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Met Ala Gly Asn Phe Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Phe Pro Gly Phe Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Val Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  26
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  26

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Val Tyr Pro Thr Leu Glu Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Tyr Gln 
        115                 120                 125             


Asn Arg Glu Val Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  27
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  27

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Leu Lys Lys Val Tyr Gly 
        115                 120                 125             


Ser Glu Glu Tyr Phe His Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  28
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  28

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Val Lys Lys Val Trp Pro 
        115                 120                 125             


Asn Leu Glu Tyr Phe Gln Ile Val Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  29
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  29

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Phe Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Glu Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  30
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  30

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Phe Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Glu Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  31
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  31

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  32
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  32

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Phe Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Ser Pro 
                85                  90                  95      


Ile Ser Ser Ser Pro Gly Leu Val Ser His Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val His Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  33
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  33

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Ala Lys Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Phe Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Glu Gly Asn 
                85                  90                  95      


Tyr Lys Arg Arg Pro Arg Leu Trp Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val His Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  34
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  34

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Val Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Phe Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Glu Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  35
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  35

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Leu Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  36
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  36

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Gly Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  37

His His His His His His His His His His 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  38

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor Xa cleavage site

<400>  39

Ile Glu Gly Arg 
1               


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion peptide

<400>  40

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-tag II peptide

<400>  41

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  42

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  43

Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser 
        


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  44

Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val 
1               5                   10                  


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  45

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  46
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  46

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


Ala Ser 
65      


<210>  47
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  47

Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val 
            20                  25                  30          


<210>  48
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  48

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr 
        35                  40                  45              


Pro Ser Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser 
    50                  55                  60                  


Thr Pro Pro Thr Pro Ser Pro Ser Ala Ser 
65                  70                  


<210>  49
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  49

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            20                  25                  30          


Ala Pro Ala Pro Ser Ala Pro Ala 
        35                  40  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  50

Val Asp Asp Ile Glu Gly Arg Met Asp Glu 
1               5                   10  


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  51

Glu Asn Leu Tyr Phe Gln Gly Arg Met Asp Glu 
1               5                   10      


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  52

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain CDR1 sequence

<400>  53

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain CDR2 sequence

<400>  54

Ile Gly Thr Gly Gly Gly Thr 
1               5           


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain CDR3 sequence

<400>  55

Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Phe Phe Asp Cys 
1               5                   10                  


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain CDR1 sequence

<400>  56

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain CDR3 sequence

<400>  57

Gln Gln Tyr Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  58
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain variable region

<400>  58

Glu Gly Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Thr Gly Gly Gly Thr Tyr Ser Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Phe Phe Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain variable region

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  60

Glu Gly Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gly Thr Gly Gly Gly Thr Tyr Ser Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Phe Phe Asp Cys Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  61
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  62
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  62

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Arg Ala Gly Asn Asn Gln Leu Arg Glu Asp Lys Ser Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr His Val His Phe Ser Thr Lys Lys Cys Arg Tyr Ile Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Leu Thr Ser Pro Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  63
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  63

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Arg Ala Gly Asn Asn Gln Leu Arg Glu Asp Lys Ser Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr His Val His Phe Ser Thr Lys Lys Cys Arg Tyr Ile Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Leu Thr Ser Pro Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Tyr Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr 
305                 310                 315                 320 


Gln Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  64
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  64

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val Ile 
65                  70                  75                  80  


Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Gln Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Val Lys Lys Val Trp Pro 
        115                 120                 125             


Asn Leu Glu Tyr Phe Gln Ile Val Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Tyr Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr 
305                 310                 315                 320 


Gln Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  65
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  65

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Arg Ala Gly Asn Asn Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr His Val His Phe Met Thr Lys Lys Cys Arg Tyr Ile Ile 
65                  70                  75                  80  


Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Ala 
                85                  90                  95      


Ile Lys Ser Gly Pro Gly Met Thr Ser Pro Leu Val Arg Ile Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Asn Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Lys Ile Leu Arg Ile Asp Lys Gln 
225                 230                 235                 240 


Pro Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Ser Val Arg Phe Glu Ala Arg Ser Cys Ser Tyr Thr 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asn Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  66
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  66

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Lys Ile Leu Arg Ile Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Arg Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Arg Ala Gly Asn Asn Arg Leu Arg Glu Asp Lys Asp 
225                 230                 235                 240 


Pro Pro Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr His Val His Phe Met Thr Lys Lys Cys Arg Tyr Ile 
            260                 265                 270         


Ile Asp Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
        275                 280                 285             


Ala Ile Lys Ser Gly Pro Gly Met Thr Ser Pro Leu Val Arg Ile Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Asn 
305                 310                 315                 320 


Gln Asn Arg Glu Trp Phe Thr Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  67
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  67

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Lys Ile Leu Arg Ile Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Arg Ser Cys Ser Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Ile Lys Leu Arg Glu Asp Lys Asp 
225                 230                 235                 240 


Pro Phe Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Glu Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Phe 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  68
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  68

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ser 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  69
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  69

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Ser Tyr Thr Ser 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Thr Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp 
225                 230                 235                 240 


Pro Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val 
            260                 265                 270         


Ile Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
        275                 280                 285             


Ala Ile Lys Ser Tyr Pro Gly Leu Thr Ser Gln Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Val Lys Lys Val Trp 
305                 310                 315                 320 


Pro Asn Leu Glu Tyr Phe Gln Ile Val Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  70
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  70

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Asp 
                85                  90                  95      


Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Tyr Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr 
305                 310                 315                 320 


Gln Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  71
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  71

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Asn Lys Ser Cys Val Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Thr Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  72
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  72

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Asn Lys Ser Cys Val Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Thr Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp 
225                 230                 235                 240 


Pro Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val 
            260                 265                 270         


Ile Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
        275                 280                 285             


Ala Ile Lys Ser Tyr Pro Gly Leu Thr Ser Gln Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Val Lys Lys Val Trp 
305                 310                 315                 320 


Pro Asn Leu Glu Tyr Phe Gln Ile Val Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  73
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  73

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Tyr Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Asn Lys Ser Cys Val Tyr Thr Ser 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Thr Gly Asn 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Phe Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  74
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  74

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Tyr 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Gln Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  75
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  75

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Tyr 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Leu Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp 
225                 230                 235                 240 


Pro Ser Lys Met Gly Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Gln Val Gln Phe Asp Asp Lys Lys Cys Leu Tyr Val 
            260                 265                 270         


Ile Glu Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly 
        275                 280                 285             


Ala Ile Lys Ser Tyr Pro Gly Leu Thr Ser Gln Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Val Lys Lys Val Trp 
305                 310                 315                 320 


Pro Asn Leu Glu Tyr Phe Gln Ile Val Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  76
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  76

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Gln Pro 
        35                  40                  45              


Ala Lys Met Phe Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asp Val Thr Ser Val Arg Phe Glu Ala Lys Ser Cys Lys Tyr Thr Ile 
65                  70                  75                  80  


Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly Tyr 
                85                  90                  95      


Ile Lys Ser Ala Pro Gly Gln Thr Ser Thr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys His Val Thr Gln 
        115                 120                 125             


Asn Arg Glu Ile Phe Val Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys 
        195                 200                 205             


Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp 
    210                 215                 220                 


Tyr Val Val Gly Trp Ala Gly Asn Val Lys Leu Arg Glu Asp Lys Gln 
225                 230                 235                 240 


Pro Leu Lys Met Ser Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser 
                245                 250                 255     


Tyr Asp Val Thr Glu Val Val Phe Glu Gln Lys Lys Cys His Tyr Ile 
            260                 265                 270         


Ile Lys Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Ala Gly 
        275                 280                 285             


Asp Ile Lys Ser Pro Pro Gly Tyr Thr Ser Ser Leu Val Arg Val Val 
    290                 295                 300                 


Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser 
305                 310                 315                 320 


Gln Asn Arg Glu Phe Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu 
                325                 330                 335     


Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu 
            340                 345                 350         


Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys 
        355                 360                 365             


Ile Asp Gly 
    370     


<210>  77
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CTGF domains 1 and 2 with Fc Tag

<400>  77

Gln Asn Cys Ser Gly Pro Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys His Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Met Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Arg Met Asp Glu Asp Lys 
145                 150                 155                 160 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        195                 200                 205             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys 
385 


<210>  78
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine CTGF domains 1 and 2 with Fc Tag

<400>  78

Gln Asp Cys Ser Ala Gln Cys Gln Cys Ala Ala Glu Ala Ala Pro His 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly 
65                  70                  75                  80  


Gly Ser Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Gly Gly 
    130                 135                 140                 


Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Arg Met Asp Glu Asp Lys 
145                 150                 155                 160 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        195                 200                 205             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys 
385 


<210>  79
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CTGF fragment

<400>  79

Gln Asn Cys Ser Gly Pro Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Met Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp Gln Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Ile Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met Lys 
        275                 280                 285             


Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  80
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine CTGF fragment with Fc tag

<400>  80

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Arg Met 
225                 230                 235                 240 


Asp Glu Gln Asp Cys Ser Ala Gln Cys Gln Cys Ala Ala Glu Ala Ala 
                245                 250                 255     


Pro His Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys 
            260                 265                 270         


Cys Arg Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp 
        275                 280                 285             


Pro Cys Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala 
    290                 295                 300                 


Asn Arg Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val 
305                 310                 315                 320 


Phe Gly Gly Ser Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys 
                325                 330                 335     


Lys Tyr Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu 
            340                 345                 350         


Cys Ser Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg 
        355                 360                 365             


Arg Val Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu 
    370                 375                 380                 


Pro Lys Asp Arg Thr Ala Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu 
385                 390                 395                 400 


Glu Asp Thr Phe Gly Pro Asp Pro Thr Met Met Arg Ala Asn Cys Leu 
                405                 410                 415     


Val Gln Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly 
            420                 425                 430         


Ile Ser Thr Arg Val Thr Asn Asp Asn Thr Phe Cys Arg Leu Glu Lys 
        435                 440                 445             


Gln Ser Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu 
    450                 455                 460                 


Asn Ile Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ala Lys 
465                 470                 475                 480 


Pro Val Lys Phe Glu Leu Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg 
                485                 490                 495     


Ala Lys Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His 
            500                 505                 510         


Arg Thr Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Ile 
        515                 520                 525             


Met Lys Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn 
    530                 535                 540                 


Cys Pro Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met 
545                 550                 555                 560 


Tyr Gly Asp Met Ala 
                565 


<210>  81
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus CTGF fragment with Fc tag

<400>  81

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Arg Met 
225                 230                 235                 240 


Asp Glu Gln Asn Cys Ser Gly Pro Cys Arg Cys Pro Ala Glu Gln Ala 
                245                 250                 255     


Pro Arg Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys 
            260                 265                 270         


Cys Arg Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp 
        275                 280                 285             


Pro Cys Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala 
    290                 295                 300                 


Asn Arg Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Ile 
305                 310                 315                 320 


Phe Gly Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys 
                325                 330                 335     


Lys Tyr Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Met Pro Leu 
            340                 345                 350         


Cys Ser Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg 
        355                 360                 365             


Arg Val Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu 
    370                 375                 380                 


Pro Lys Asp Gln Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu 
385                 390                 395                 400 


Glu Asp Thr Phe Gly Pro Asp Pro Thr Met Ile Arg Ala Asn Cys Leu 
                405                 410                 415     


Val Gln Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly 
            420                 425                 430         


Ile Ser Thr Arg Val Thr Asn Asp Asn Ala Ser Cys Arg Leu Glu Lys 
        435                 440                 445             


Gln Ser Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu 
    450                 455                 460                 


Asn Ile Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys 
465                 470                 475                 480 


Pro Ile Lys Phe Glu Leu Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg 
                485                 490                 495     


Ala Lys Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His 
            500                 505                 510         


Arg Thr Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val 
        515                 520                 525             


Met Lys Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn 
    530                 535                 540                 


Cys Pro Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met 
545                 550                 555                 560 


Tyr Gly Asp Met Ala 
                565 


<210>  82
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rat CTGF fragment

<400>  82

Gln Asp Cys Ser Ala Gln Cys Gln Cys Ala Ala Glu Ala Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly 
65                  70                  75                  80  


Gly Ser Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp Arg Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Met Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Thr Phe Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ala Lys Pro Val 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Ile Met Lys 
        275                 280                 285             


Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala 
            


<210>  83
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CTGF fragment with Fc tag

<400>  83

Gln Asn Cys Ser Gly Pro Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg 
1               5                   10                  15      


Cys Pro Ala Gly Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg 
            20                  25                  30          


Val Cys Ala Lys Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys 
        35                  40                  45              


Asp Pro His Lys Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg 
    50                  55                  60                  


Lys Ile Gly Val Cys Thr Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly 
65                  70                  75                  80  


Gly Thr Val Tyr Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr 
                85                  90                  95      


Gln Cys Thr Cys Leu Asp Gly Ala Val Gly Cys Met Pro Leu Cys Ser 
            100                 105                 110         


Met Asp Val Arg Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val 
        115                 120                 125             


Lys Leu Pro Gly Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys 
    130                 135                 140                 


Asp Gln Thr Val Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Thr Phe Gly Pro Asp Pro Thr Met Ile Arg Ala Asn Cys Leu Val Gln 
                165                 170                 175     


Thr Thr Glu Trp Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser 
            180                 185                 190         


Thr Arg Val Thr Asn Asp Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser 
        195                 200                 205             


Arg Leu Cys Met Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile 
    210                 215                 220                 


Lys Lys Gly Lys Lys Cys Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile 
225                 230                 235                 240 


Lys Phe Glu Leu Ser Gly Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys 
                245                 250                 255     


Phe Cys Gly Val Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr 
            260                 265                 270         


Thr Thr Leu Pro Val Glu Phe Lys Cys Pro Asp Gly Glu Val Met Lys 
        275                 280                 285             


Lys Asn Met Met Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro 
    290                 295                 300                 


Gly Asp Asn Asp Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly 
305                 310                 315                 320 


Asp Met Ala Val Asp Asp Ile Glu Gly Arg Met Asp Glu Pro Lys Ser 
                325                 330                 335     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            340                 345                 350         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        355                 360                 365             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    370                 375                 380                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
385                 390                 395                 400 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                405                 410                 415     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            420                 425                 430         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        435                 440                 445             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    450                 455                 460                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                485                 490                 495     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            500                 505                 510         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        515                 520                 525             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    530                 535                 540                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
545                 550                 555                 560 


Ser Pro Gly Lys 
                


<210>  84
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine CTGF fragment with GST tag

<400>  84

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gln Asp Cys Ser 
    210                 215                 220                 


Ala Gln Cys Gln Cys Ala Ala Glu Ala Ala Pro His Cys Pro Ala Gly 
225                 230                 235                 240 


Val Ser Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys 
                245                 250                 255     


Gln Leu Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys 
            260                 265                 270         


Gly Leu Phe Cys Asp Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val 
        275                 280                 285             


Cys Thr Ala Lys Asp Gly Ala Pro Cys Val Phe Gly Gly Ser Val Tyr 
    290                 295                 300                 


Arg Ser Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys 
305                 310                 315                 320 


Leu Asp Gly Ala Val Gly Cys Val Pro Leu Cys Ser Met Asp Val Arg 
                325                 330                 335     


Leu Pro Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly 
            340                 345                 350         


Lys Cys Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Arg Thr Ala 
        355                 360                 365             


Val Gly Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro 
    370                 375                 380                 


Asp Pro Thr Met Met Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp 
385                 390                 395                 400 


Ser Ala Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr 
                405                 410                 415     


Asn Asp Asn Thr Phe Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met 
            420                 425                 430         


Val Arg Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys 
        435                 440                 445             


Lys Cys Ile Arg Thr Pro Lys Ile Ala Lys Pro Val Lys Phe Glu Leu 
    450                 455                 460                 


Ser Gly Cys Thr Ser Val Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val 
465                 470                 475                 480 


Cys Thr Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro 
                485                 490                 495     


Val Glu Phe Lys Cys Pro Asp Gly Glu Ile Met Lys Lys Asn Met Met 
            500                 505                 510         


Phe Ile Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp 
        515                 520                 525             


Ile Phe Glu Ser Leu Tyr Tyr Arg Lys Met Tyr 
    530                 535                 


