               SEQUENCE LISTING

<110> DSM IP Assets B.V.

<120> ENZYME COMPOSITION

<130> 33962-WO-PCT

<150> EP21166963.5
<151> 2021-04-06

<160> 7

<170> BiSSAP 1.3.6

<210> 1
<211> 1932
<212> DNA
<213> Rasamsonia emersonii


<220> 
<223> Glucoamylase

<400> 1
atggctcctc ctctgtccta tgcgctgttc gcgctcgctc tcagcccggc ggtcatggca      60

gaccctctgc tgaaatcgcg cgcaacggcc agcctgagca gctggctggc cacggagacg     120

tcgtatgcgc tcgaggctat cctgaacaac atcggctcgt cgggtgcgtg ggcgcaatca     180

gccagcccag gcatcgtcgt ggccagtccc agcacgagcg atccagatta ctactacacc     240

tggacgcgag actcagcgct gaccttaaag gtgctgatcg acctcttcaa gaacggcaac     300

tccagcctcc agggcgtgat cgaggagtat atcgatgcgc aggcctatct ccagacggta     360

tccaatccgt ctggcaccct gtctacgggt ggcctggggg agcccaagtt caatgtcgac     420

aaaaccgcat ttaccggcag ctgggggcgt ccgcagcgag atggtccggc cctgcgagct     480

actgcgctga tttcttttgg cgaatggctg attgataatg gctattcgac gtatgcgtct     540

gatattgtgt ggcccattgt gcgcaatgat ctgtcatatg tcgcacagta ttggaacgag     600

accggttacg atctctggga ggaagtcgac gggtcttcgt tctttaccgt cgccgtccag     660

catcgcgcgc tggttgaggg agccaacttt gccagcgcac tgggaacgtc atgcgactac     720

tgtacctctc aggctcctga gatcctctgc tacctgcagt ccttctggac ggggtcctac     780

atcttggcca acttccagag cagccgctca ggaaaggacg tcaacaccat cctaggcagc     840

atccacacgt tcgaccctga agcggcctgc gatgacacca ccttccagcc ctgctcacca     900

agagcactcg cgaatcataa agtggtggtg gatgccttcc gagacctcta cactatcaac     960

aacaatgccg ctgaaggtgt agccgtggct gtgggtcggt atcctgaaga cacatactat    1020

aacggcaacc cgtggttctt gtgtacgctt gctgcagccg agcagctgta tgatgctctg    1080

tatcagtgga acaacattgg atccattacc atcaccgacg tctctttgga tttcttccag    1140

gacttgtata gcgatgccgc ggtgggcacg tactcttcct cgagctccga gtacagtgcg    1200

atcgtcgatg ccgtgaagac ctacgccgac ggattcgtga gcatcgtgga aaactatgca    1260

ctgacgaatg gatctctgtc cgagcaatac tccaagacgg acgggacaca ggagtccgct    1320

cgcgatctca cctggtcgta tgctgccctg ctaacggcca acatgcgtcg caactcgata    1380

gtgcccgcag cctggggtga gacggctgcc agcagtgtgc cggcgacctg tgtgtccacg    1440

tcggccacag gcatctacag cactgctacg gacacagcct ggccgagcac gttgactgca    1500

gccacaacga cagcaacagc gacgacaacg acaacgacaa ccacgagcaa gaccacaaca    1560

agcacaggaa catccaccat ctcaacaacc tcctcctcat catcatgtac gaccccaaca    1620

tccgtagccg taaccttcaa gctaaccgca acaacctact acggagaaaa catcaagatg    1680

tcaggctcaa tcccgcagct cggcgactgg gacacagacg acgcagtggc cctgagcgca    1740

gcaaactaca cgagcactga cccgctgtgg ttcgtcacca tcaacctgcc cgcaggcgag    1800

tcatttgagt acaagtacat ccgcatcgag agcgacggga cgatcgagtg ggagagtgat    1860

ccgaaccggt cgtacacggt tcctgcggct tgtggtgaga cggctgctgt tgagagcgat    1920

acgtggcggt aa                                                        1932


<210> 2
<211> 643
<212> PRT
<213> Rasamsonia emersonii


<220> 
<223> Glucoamylase

<400> 2
Met Ala Pro Pro Leu Ser Tyr Ala Leu Phe Ala Leu Ala Leu Ser Pro 
1               5                   10                  15      
Ala Val Met Ala Asp Pro Leu Leu Lys Ser Arg Ala Thr Ala Ser Leu 
            20                  25                  30          
Ser Ser Trp Leu Ala Thr Glu Thr Ser Tyr Ala Leu Glu Ala Ile Leu 
        35                  40                  45              
Asn Asn Ile Gly Ser Ser Gly Ala Trp Ala Gln Ser Ala Ser Pro Gly 
    50                  55                  60                  
Ile Val Val Ala Ser Pro Ser Thr Ser Asp Pro Asp Tyr Tyr Tyr Thr 
65                  70                  75                  80  
Trp Thr Arg Asp Ser Ala Leu Thr Leu Lys Val Leu Ile Asp Leu Phe 
                85                  90                  95      
Lys Asn Gly Asn Ser Ser Leu Gln Gly Val Ile Glu Glu Tyr Ile Asp 
            100                 105                 110         
Ala Gln Ala Tyr Leu Gln Thr Val Ser Asn Pro Ser Gly Thr Leu Ser 
        115                 120                 125             
Thr Gly Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Lys Thr Ala Phe 
    130                 135                 140                 
Thr Gly Ser Trp Gly Arg Pro Gln Arg Asp Gly Pro Ala Leu Arg Ala 
145                 150                 155                 160 
Thr Ala Leu Ile Ser Phe Gly Glu Trp Leu Ile Asp Asn Gly Tyr Ser 
                165                 170                 175     
Thr Tyr Ala Ser Asp Ile Val Trp Pro Ile Val Arg Asn Asp Leu Ser 
            180                 185                 190         
Tyr Val Ala Gln Tyr Trp Asn Glu Thr Gly Tyr Asp Leu Trp Glu Glu 
        195                 200                 205             
Val Asp Gly Ser Ser Phe Phe Thr Val Ala Val Gln His Arg Ala Leu 
    210                 215                 220                 
Val Glu Gly Ala Asn Phe Ala Ser Ala Leu Gly Thr Ser Cys Asp Tyr 
225                 230                 235                 240 
Cys Thr Ser Gln Ala Pro Glu Ile Leu Cys Tyr Leu Gln Ser Phe Trp 
                245                 250                 255     
Thr Gly Ser Tyr Ile Leu Ala Asn Phe Gln Ser Ser Arg Ser Gly Lys 
            260                 265                 270         
Asp Val Asn Thr Ile Leu Gly Ser Ile His Thr Phe Asp Pro Glu Ala 
        275                 280                 285             
Ala Cys Asp Asp Thr Thr Phe Gln Pro Cys Ser Pro Arg Ala Leu Ala 
    290                 295                 300                 
Asn His Lys Val Val Val Asp Ala Phe Arg Asp Leu Tyr Thr Ile Asn 
305                 310                 315                 320 
Asn Asn Ala Ala Glu Gly Val Ala Val Ala Val Gly Arg Tyr Pro Glu 
                325                 330                 335     
Asp Thr Tyr Tyr Asn Gly Asn Pro Trp Phe Leu Cys Thr Leu Ala Ala 
            340                 345                 350         
Ala Glu Gln Leu Tyr Asp Ala Leu Tyr Gln Trp Asn Asn Ile Gly Ser 
        355                 360                 365             
Ile Thr Ile Thr Asp Val Ser Leu Asp Phe Phe Gln Asp Leu Tyr Ser 
    370                 375                 380                 
Asp Ala Ala Val Gly Thr Tyr Ser Ser Ser Ser Ser Glu Tyr Ser Ala 
385                 390                 395                 400 
Ile Val Asp Ala Val Lys Thr Tyr Ala Asp Gly Phe Val Ser Ile Val 
                405                 410                 415     
Glu Asn Tyr Ala Leu Thr Asn Gly Ser Leu Ser Glu Gln Tyr Ser Lys 
            420                 425                 430         
Thr Asp Gly Thr Gln Glu Ser Ala Arg Asp Leu Thr Trp Ser Tyr Ala 
        435                 440                 445             
Ala Leu Leu Thr Ala Asn Met Arg Arg Asn Ser Ile Val Pro Ala Ala 
    450                 455                 460                 
Trp Gly Glu Thr Ala Ala Ser Ser Val Pro Ala Thr Cys Val Ser Thr 
465                 470                 475                 480 
Ser Ala Thr Gly Ile Tyr Ser Thr Ala Thr Asp Thr Ala Trp Pro Ser 
                485                 490                 495     
Thr Leu Thr Ala Ala Thr Thr Thr Ala Thr Ala Thr Thr Thr Thr Thr 
            500                 505                 510         
Thr Thr Thr Ser Lys Thr Thr Thr Ser Thr Gly Thr Ser Thr Ile Ser 
        515                 520                 525             
Thr Thr Ser Ser Ser Ser Ser Cys Thr Thr Pro Thr Ser Val Ala Val 
    530                 535                 540                 
Thr Phe Lys Leu Thr Ala Thr Thr Tyr Tyr Gly Glu Asn Ile Lys Met 
545                 550                 555                 560 
Ser Gly Ser Ile Pro Gln Leu Gly Asp Trp Asp Thr Asp Asp Ala Val 
                565                 570                 575     
Ala Leu Ser Ala Ala Asn Tyr Thr Ser Thr Asp Pro Leu Trp Phe Val 
            580                 585                 590         
Thr Ile Asn Leu Pro Ala Gly Glu Ser Phe Glu Tyr Lys Tyr Ile Arg 
        595                 600                 605             
Ile Glu Ser Asp Gly Thr Ile Glu Trp Glu Ser Asp Pro Asn Arg Ser 
    610                 615                 620                 
Tyr Thr Val Pro Ala Ala Cys Gly Glu Thr Ala Ala Val Glu Ser Asp 
625                 630                 635                 640 
Thr Trp Arg 
            

<210> 3
<211> 1368
<212> DNA
<213> Rasamsonia emersonii


<220> 
<223> Cellobiohydrolase I

<400> 3
atgcttcgac gggctcttct tctatcctct tctgccatcc ttgctgtcaa agcacagcag      60

gctggcacgg cgactgcgga gaaccacccg cccctgacat ggcaggagtg caccgctcct     120

gggagctgca caacccagaa cggtgcggtc gttcttgatt cgaactggcg ttgggtgcac     180

aatgtcgggg gctacaccaa ctgctacacg ggcaacacct ggaacccaac gtactgcccg     240

gacgacgtca cctgcgccga gaattgtgcg ctggacggcg cggattacga gggcacctac     300

ggcgtgactt cgtccggcag cgagttgagg ctcaattttg tcaccgggtc gaacgttgga     360

tctcgtctct acctgttgca ggacgacgag acctatcaga tcttcaagct cctgaaccgg     420

gaattcacct ttgacgtcga tgtctccaat ctcccgtgcg gattgaacgg cgctctgtac     480

tttgttgcca tggacgctga cggcggcgtg tccaagtacc cgaacaacaa ggctggtgcc     540

aagtacggaa ccgggtattg cgattcccaa tgcccacggg acctcaagtt tatcgacggc     600

gagggaaacg tcgagggctg gcagccgtct tcgaacaacg ccaacactgg gattggcgac     660

cacggctcgt gctgcgctga gatggatgtc tgggaagcca acagcatctc caatgcggtc     720

actccgcacc catgcgacac gccaggacag acgatgtgcg atggggatga ctgcggtggc     780

acatactcta ccaaccgcta tgcgggagag tgtgatcctg acggctgtga cttcaaccct     840

taccgcatgg gcaacacttc tttctacggg cctggcaaga ttatcgacac cacccagccc     900

ttcactgttg tgacgcagtt cctcactgat gacggtactg acaccggcac cctcagcgag     960

atcaagcgct tctacatcca gaacggcaaa gtcattccgc agcccaactc cgacatcgcc    1020

ggcgtgactg gcaactcgat caccaccgag ttctgcactg ctcagaagca ggcctttggc    1080

gacactgacg atttctccaa gcacggtgga ctggccagca tgggagctgc catgcagcag    1140

ggcatggtcc tggtgatgag tttgtgggac gactatgccg cacaaatgct gtggctggat    1200

tccgactacc cgaccaacgc gtccgccacc acgcctggtg ttgcccgagg aacatgtccg    1260

acggactcgg gcgtcccatc gcaggtcgag tcgcagagcc ccaactcgta cgtgacgtac    1320

tcgaacatca agtttggtcc gatcaactcg acctttaccg cttcataa                 1368


<210> 4
<211> 455
<212> PRT
<213> Rasamsonia emersonii


<220> 
<223> Cellobiohydrolase I

<400> 4
Met Leu Arg Arg Ala Leu Leu Leu Ser Ser Ser Ala Ile Leu Ala Val 
1               5                   10                  15      
Lys Ala Gln Gln Ala Gly Thr Ala Thr Ala Glu Asn His Pro Pro Leu 
            20                  25                  30          
Thr Trp Gln Glu Cys Thr Ala Pro Gly Ser Cys Thr Thr Gln Asn Gly 
        35                  40                  45              
Ala Val Val Leu Asp Ser Asn Trp Arg Trp Val His Asn Val Gly Gly 
    50                  55                  60                  
Tyr Thr Asn Cys Tyr Thr Gly Asn Thr Trp Asn Pro Thr Tyr Cys Pro 
65                  70                  75                  80  
Asp Asp Val Thr Cys Ala Glu Asn Cys Ala Leu Asp Gly Ala Asp Tyr 
                85                  90                  95      
Glu Gly Thr Tyr Gly Val Thr Ser Ser Gly Ser Glu Leu Arg Leu Asn 
            100                 105                 110         
Phe Val Thr Gly Ser Asn Val Gly Ser Arg Leu Tyr Leu Leu Gln Asp 
        115                 120                 125             
Asp Glu Thr Tyr Gln Ile Phe Lys Leu Leu Asn Arg Glu Phe Thr Phe 
    130                 135                 140                 
Asp Val Asp Val Ser Asn Leu Pro Cys Gly Leu Asn Gly Ala Leu Tyr 
145                 150                 155                 160 
Phe Val Ala Met Asp Ala Asp Gly Gly Val Ser Lys Tyr Pro Asn Asn 
                165                 170                 175     
Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln Cys Pro 
            180                 185                 190         
Arg Asp Leu Lys Phe Ile Asp Gly Glu Gly Asn Val Glu Gly Trp Gln 
        195                 200                 205             
Pro Ser Ser Asn Asn Ala Asn Thr Gly Ile Gly Asp His Gly Ser Cys 
    210                 215                 220                 
Cys Ala Glu Met Asp Val Trp Glu Ala Asn Ser Ile Ser Asn Ala Val 
225                 230                 235                 240 
Thr Pro His Pro Cys Asp Thr Pro Gly Gln Thr Met Cys Asp Gly Asp 
                245                 250                 255     
Asp Cys Gly Gly Thr Tyr Ser Thr Asn Arg Tyr Ala Gly Glu Cys Asp 
            260                 265                 270         
Pro Asp Gly Cys Asp Phe Asn Pro Tyr Arg Met Gly Asn Thr Ser Phe 
        275                 280                 285             
Tyr Gly Pro Gly Lys Ile Ile Asp Thr Thr Gln Pro Phe Thr Val Val 
    290                 295                 300                 
Thr Gln Phe Leu Thr Asp Asp Gly Thr Asp Thr Gly Thr Leu Ser Glu 
305                 310                 315                 320 
Ile Lys Arg Phe Tyr Ile Gln Asn Gly Lys Val Ile Pro Gln Pro Asn 
                325                 330                 335     
Ser Asp Ile Ala Gly Val Thr Gly Asn Ser Ile Thr Thr Glu Phe Cys 
            340                 345                 350         
Thr Ala Gln Lys Gln Ala Phe Gly Asp Thr Asp Asp Phe Ser Lys His 
        355                 360                 365             
Gly Gly Leu Ala Ser Met Gly Ala Ala Met Gln Gln Gly Met Val Leu 
    370                 375                 380                 
Val Met Ser Leu Trp Asp Asp Tyr Ala Ala Gln Met Leu Trp Leu Asp 
385                 390                 395                 400 
Ser Asp Tyr Pro Thr Asn Ala Ser Ala Thr Thr Pro Gly Val Ala Arg 
                405                 410                 415     
Gly Thr Cys Pro Thr Asp Ser Gly Val Pro Ser Gln Val Glu Ser Gln 
            420                 425                 430         
Ser Pro Asn Ser Tyr Val Thr Tyr Ser Asn Ile Lys Phe Gly Pro Ile 
        435                 440                 445             
Asn Ser Thr Phe Thr Ala Ser 
    450                 455 

<210> 5
<211> 1368
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cellobiohydrolase I

<400> 5
atgctccgcc gtgctctcct gctgagcagc tctgccatcc tggccgtcaa ggcccagcag      60

gctggtactg ccactgctga gaaccaccct cccttgacct ggcaggagtg cactgctcct     120

ggttcctgca ccactcagaa cggtgctgtt gtccttgaca gcaactggag atgggttcac     180

aacgtcggtg gttacaccaa ctgctacact ggcaacacct ggaaccccac ctactgcccc     240

gatgatgtca cctgcgctga gaactgcgct cttgacggtg ccgactacga gggtacctac     300

ggtgtcactt cttctggctc tgagctccgt ctgaacttcg tcaccggcag caacgtcggc     360

tctcgcctct acctcctcca ggatgacgag acttaccaga tcttcaagct cctcaaccgt     420

gagttcacct tcgatgttga tgtctccaac cttccttgcg gtctgaacgg tgctctgtac     480

ttcgtcgcca tggatgccga cggtggtgtc tccaagtacc ccaacaacaa ggccggtgcc     540

aagtacggta ccggttactg cgacagccag tgcccccgtg acctcaagtt cattgacggc     600

gagggcaacg tcgagggctg gcagccctcc tccaacaacg ccaacactgg tatcggtgac     660

cacggctctt gctgcgctga gatggatgtc tgggaggcca actccatctc caacgccgtc     720

accccccacc cttgcgacac ccccggccag accatgtgcg atggtgatga ctgcggtggt     780

acctactcca ccaaccgcta cgccggtgag tgcgaccccg atggctgcga cttcaacccc     840

taccgcatgg gcaacacctc cttctacggc cctggcaaga tcattgacac cacccagccc     900

ttcaccgttg tcacccagtt cctgaccgat gacggcaccg acactggtac cctctccgag     960

atcaagcgct tctacatcca gaacggcaag gtcatccccc agcccaactc cgacatcgcc    1020

ggtgtcaccg gcaactccat caccactgag ttctgcactg ctcagaagca ggctttcggt    1080

gacaccgatg acttctccaa gcacggtggt cttgcctcca tgggtgctgc catgcagcag    1140

ggtatggtcc tggtcatgtc cctctgggat gactacgctg ctcagatgct ctggctcgac    1200

tccgactacc ccaccaacgc ctccgccacc actcctggtg ttgctcgtgg tacctgcccc    1260

accgactctg gtgttcctag ccaggttgag agccagtccc ccaactccta cgtgacctac    1320

tccaacatca agttcggtcc catcaactcc accttcactg catcgtaa                 1368


<210> 6
<211> 2577
<212> DNA
<213> Rasamsonia emersonii


<220> 
<223> Beta-glucosidase

<400> 6
atgaggaacg ggttgctcaa ggtcgccgcc cttgcggccg cttcggtcgt caatggcgag      60

aacctggctt attcacctcc cttctaccct tcgccgtggg ccaatggaca gggcgactgg     120

gcagaggcct acgagaaggc cgtcaagttt gtctcccaac tcacgctggc cgaaaaggtc     180

aacctgacca ccggaactgg ttgggagcag gaccgatgcg tcggccaagt gggtagcatc     240

ccaagattgg gcttcccagg actttgcatg caggactctc cgctgggtgt tcgagacact     300

gactacaact cggccttccc ggcgggtgtc aatgtcgctg ctacctggaa cagggacctc     360

gcctaccgtc gcggccaagc gatgggcgag gagcatcgcg gaaaaggtgt cgacgttcag     420

ctgggccctg tggccggccc gctgggcagg tctcccgatg ctggcagaaa ctgggaaggt     480

ttcgccccgg atcccgtgct gaccggaaac atgatggcgt ccaccatcca gggtattcaa     540

gatgctggtg tcattgcttg cgccaagcat ttcatcctct acgagcagga gcatttccgt     600

cagggcgctc aagatggcta cgatatctcc gacagtatca gtgccaacgc cgatgacaag     660

actatgcacg agttgtactt gtggcctttt gccgatgctg ttcgcgctgg cgttggttca     720

atcatgtgct cctacaacca ggtgaacaac agctacgcct gctccaacag ctacaccatg     780

aacaagctgc tcaagagcga attgggcttc caaggcttcg tcatgaccga ctggggtggc     840

caccacagtg gtgtgggttc cgctctcgct ggtttggaca tgtcgatgcc cggagacatt     900

gccttcgaca gtggcacctc cttctggggc actaacctca cggttgccgt gctcaatgga     960

agtgttcctg agtggcgtgt tgatgacatg gctgtccgta tcatgtccgc ttattacaag    1020

gtcggccgcg accgctacag cgtccccatc aactttgact cgtggaccct ggatacctat    1080

ggtcccgagc actatgcggt gggccagggc aacaccaaga tcaacgagca cgttgatgtt    1140

cgcggcaacc atgcagaaat catccatgaa atcggtgctg ccagcgccgt ccttctcaag    1200

aacaagggtg ggcttccttt gactggcacc gaacggtttg tcggtgtttt cggagaggat    1260

gccggatcca acccttgggg tgtgaacggc tgcagtgacc gaggctgcga caatggtaca    1320

ttggccatgg gctggggcag tggtactgct aacttcccct acttggtgac gccggagcag    1380

gcgatcgaga gagaagtcgt gtcccgaaat ggaaccttca ccgccatcac ggacaatggc    1440

gctcttgagc agatggcggc tgtcgcctct caggctgatg tttgcctggt cttcgccaac    1500

gccgactccg gagaaggcta catcaacgtc gacggcaatg agggtgaccg gaagaatctg    1560

accctgtggc aaggggcgga tcaagtcatc cacaacgtca ctgccaactg caacaacacc    1620

gtcgtggtgt tgcacactgt cggccccgtt ttgatcgatg attggtatga ccaccccaac    1680

gtcactgcca ttctctgggc tggtcttccg ggccaggaga gcggtaactc gctcgtcgat    1740

gtcctctacg gccgtgtcaa ccctggcgga aagactccgt tcacctgggg acggacccgg    1800

gaggattacg gtgctcctct ggtcctgaag ccgaacaatg gcaagggcgc cccgcagcag    1860

gacttcactg agggtatctt catcgactac cgtcggtttg acaagtacaa catcaccccc    1920

atctacgaat tcggattcgg tctgagctac actacctttg agttttctga gctcaatgtg    1980

cagcctatca atacgccgcc gtacactccc gcttctggct tcaccaaggc ggcgcagtca    2040

ttcggcccgt cgtccaatgc ttctgacaac ctgtacccca gcgacattga gcgggtcccg    2100

ttgtacatct acccatggct caactccacc gatttgaagg cgtccgccaa tgaccctgac    2160

tatgggttgc ctaacgacaa atacgttcct cccaacgcca cgaacggtaa cccgcagccc    2220

attaacccgg ctggcggtgc tcctggtggc aaccctagtc tctatgagcc tgttgctcgg    2280

gtctcagcca tcatcaccaa caccggtaag gttacgggtg acgaggttcc tcaactgtat    2340

gtctctcttg gcggtcccga tgatgccccc aaggttcttc gtggcttcga ccgtatcaca    2400

cttgcgcctg gtcagcagac cttgtggacg accaccctga cgaggcgaga catctcgaac    2460

tgggaccctg tcacccagaa ctgggttgtg accaactaca ccaagacggt gtatgttggc    2520

aactcctccc gcaacctgcc tttgcaggca ccccttaagc catatcctgg aatctaa       2577


<210> 7
<211> 858
<212> PRT
<213> Rasamsonia emersonii


<220> 
<223> Beta-glucosidase

<400> 7
Met Arg Asn Gly Leu Leu Lys Val Ala Ala Leu Ala Ala Ala Ser Val 
1               5                   10                  15      
Val Asn Gly Glu Asn Leu Ala Tyr Ser Pro Pro Phe Tyr Pro Ser Pro 
            20                  25                  30          
Trp Ala Asn Gly Gln Gly Asp Trp Ala Glu Ala Tyr Glu Lys Ala Val 
        35                  40                  45              
Lys Phe Val Ser Gln Leu Thr Leu Ala Glu Lys Val Asn Leu Thr Thr 
    50                  55                  60                  
Gly Thr Gly Trp Glu Gln Asp Arg Cys Val Gly Gln Val Gly Ser Ile 
65                  70                  75                  80  
Pro Arg Leu Gly Phe Pro Gly Leu Cys Met Gln Asp Ser Pro Leu Gly 
                85                  90                  95      
Val Arg Asp Thr Asp Tyr Asn Ser Ala Phe Pro Ala Gly Val Asn Val 
            100                 105                 110         
Ala Ala Thr Trp Asn Arg Asp Leu Ala Tyr Arg Arg Gly Gln Ala Met 
        115                 120                 125             
Gly Glu Glu His Arg Gly Lys Gly Val Asp Val Gln Leu Gly Pro Val 
    130                 135                 140                 
Ala Gly Pro Leu Gly Arg Ser Pro Asp Ala Gly Arg Asn Trp Glu Gly 
145                 150                 155                 160 
Phe Ala Pro Asp Pro Val Leu Thr Gly Asn Met Met Ala Ser Thr Ile 
                165                 170                 175     
Gln Gly Ile Gln Asp Ala Gly Val Ile Ala Cys Ala Lys His Phe Ile 
            180                 185                 190         
Leu Tyr Glu Gln Glu His Phe Arg Gln Gly Ala Gln Asp Gly Tyr Asp 
        195                 200                 205             
Ile Ser Asp Ser Ile Ser Ala Asn Ala Asp Asp Lys Thr Met His Glu 
    210                 215                 220                 
Leu Tyr Leu Trp Pro Phe Ala Asp Ala Val Arg Ala Gly Val Gly Ser 
225                 230                 235                 240 
Ile Met Cys Ser Tyr Asn Gln Val Asn Asn Ser Tyr Ala Cys Ser Asn 
                245                 250                 255     
Ser Tyr Thr Met Asn Lys Leu Leu Lys Ser Glu Leu Gly Phe Gln Gly 
            260                 265                 270         
Phe Val Met Thr Asp Trp Gly Gly His His Ser Gly Val Gly Ser Ala 
        275                 280                 285             
Leu Ala Gly Leu Asp Met Ser Met Pro Gly Asp Ile Ala Phe Asp Ser 
    290                 295                 300                 
Gly Thr Ser Phe Trp Gly Thr Asn Leu Thr Val Ala Val Leu Asn Gly 
305                 310                 315                 320 
Ser Val Pro Glu Trp Arg Val Asp Asp Met Ala Val Arg Ile Met Ser 
                325                 330                 335     
Ala Tyr Tyr Lys Val Gly Arg Asp Arg Tyr Ser Val Pro Ile Asn Phe 
            340                 345                 350         
Asp Ser Trp Thr Leu Asp Thr Tyr Gly Pro Glu His Tyr Ala Val Gly 
        355                 360                 365             
Gln Gly Asn Thr Lys Ile Asn Glu His Val Asp Val Arg Gly Asn His 
    370                 375                 380                 
Ala Glu Ile Ile His Glu Ile Gly Ala Ala Ser Ala Val Leu Leu Lys 
385                 390                 395                 400 
Asn Lys Gly Gly Leu Pro Leu Thr Gly Thr Glu Arg Phe Val Gly Val 
                405                 410                 415     
Phe Gly Glu Asp Ala Gly Ser Asn Pro Trp Gly Val Asn Gly Cys Ser 
            420                 425                 430         
Asp Arg Gly Cys Asp Asn Gly Thr Leu Ala Met Gly Trp Gly Ser Gly 
        435                 440                 445             
Thr Ala Asn Phe Pro Tyr Leu Val Thr Pro Glu Gln Ala Ile Glu Arg 
    450                 455                 460                 
Glu Val Val Ser Arg Asn Gly Thr Phe Thr Ala Ile Thr Asp Asn Gly 
465                 470                 475                 480 
Ala Leu Glu Gln Met Ala Ala Val Ala Ser Gln Ala Asp Val Cys Leu 
                485                 490                 495     
Val Phe Ala Asn Ala Asp Ser Gly Glu Gly Tyr Ile Asn Val Asp Gly 
            500                 505                 510         
Asn Glu Gly Asp Arg Lys Asn Leu Thr Leu Trp Gln Gly Ala Asp Gln 
        515                 520                 525             
Val Ile His Asn Val Thr Ala Asn Cys Asn Asn Thr Val Val Val Leu 
    530                 535                 540                 
His Thr Val Gly Pro Val Leu Ile Asp Asp Trp Tyr Asp His Pro Asn 
545                 550                 555                 560 
Val Thr Ala Ile Leu Trp Ala Gly Leu Pro Gly Gln Glu Ser Gly Asn 
                565                 570                 575     
Ser Leu Val Asp Val Leu Tyr Gly Arg Val Asn Pro Gly Gly Lys Thr 
            580                 585                 590         
Pro Phe Thr Trp Gly Arg Thr Arg Glu Asp Tyr Gly Ala Pro Leu Val 
        595                 600                 605             
Leu Lys Pro Asn Asn Gly Lys Gly Ala Pro Gln Gln Asp Phe Thr Glu 
    610                 615                 620                 
Gly Ile Phe Ile Asp Tyr Arg Arg Phe Asp Lys Tyr Asn Ile Thr Pro 
625                 630                 635                 640 
Ile Tyr Glu Phe Gly Phe Gly Leu Ser Tyr Thr Thr Phe Glu Phe Ser 
                645                 650                 655     
Glu Leu Asn Val Gln Pro Ile Asn Thr Pro Pro Tyr Thr Pro Ala Ser 
            660                 665                 670         
Gly Phe Thr Lys Ala Ala Gln Ser Phe Gly Pro Ser Ser Asn Ala Ser 
        675                 680                 685             
Asp Asn Leu Tyr Pro Ser Asp Ile Glu Arg Val Pro Leu Tyr Ile Tyr 
    690                 695                 700                 
Pro Trp Leu Asn Ser Thr Asp Leu Lys Ala Ser Ala Asn Asp Pro Asp 
705                 710                 715                 720 
Tyr Gly Leu Pro Asn Asp Lys Tyr Val Pro Pro Asn Ala Thr Asn Gly 
                725                 730                 735     
Asn Pro Gln Pro Ile Asn Pro Ala Gly Gly Ala Pro Gly Gly Asn Pro 
            740                 745                 750         
Ser Leu Tyr Glu Pro Val Ala Arg Val Ser Ala Ile Ile Thr Asn Thr 
        755                 760                 765             
Gly Lys Val Thr Gly Asp Glu Val Pro Gln Leu Tyr Val Ser Leu Gly 
    770                 775                 780                 
Gly Pro Asp Asp Ala Pro Lys Val Leu Arg Gly Phe Asp Arg Ile Thr 
785                 790                 795                 800 
Leu Ala Pro Gly Gln Gln Thr Leu Trp Thr Thr Thr Leu Thr Arg Arg 
                805                 810                 815     
Asp Ile Ser Asn Trp Asp Pro Val Thr Gln Asn Trp Val Val Thr Asn 
            820                 825                 830         
Tyr Thr Lys Thr Val Tyr Val Gly Asn Ser Ser Arg Asn Leu Pro Leu 
        835                 840                 845             
Gln Ala Pro Leu Lys Pro Tyr Pro Gly Ile 
    850                 855             

