                         SEQUENCE LISTING

<110>  PROVINCIAL HEALTH SERVICES AUTHORITY
       UVIC INDUSTRY PARTNERSHIPS INC.
       
<120>  MODIFIED GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND 
       CHIMERIC CYTOKINE RECEPTORS BINDING SAME

<130>  V818187WO

<140>  PCT/CA2022/050540
<141>  2022-04-07

<150>  63/171,933
<151>  2021-04-07

<150>  63/171,950
<151>  2021-04-07

<150>  63/171,980
<151>  2021-04-07

<150>  63/172,025
<151>  2021-04-07

<160>  231   

<170>  PatentIn version 3.5

<210>  1
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSF

<400>  1

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 
        35                  40                  45              


Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 
            100                 105                 110         


Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 
        115                 120                 125             


Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 
145                 150                 155                 160 


Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 


<210>  2
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (Ig-CRH)

<400>  2

Glu Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly 
1               5                   10                  15      


Asp Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu 
            20                  25                  30          


Asp Pro Glu Pro Gln Ile Leu Trp Arg Leu Gly Ala Glu Leu Gln Pro 
        35                  40                  45              


Gly Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile 
    50                  55                  60                  


Thr Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Ser Leu 
65                  70                  75                  80  


Asn Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala 
                85                  90                  95      


Gly Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu 
            100                 105                 110         


Thr Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His 
        115                 120                 125             


Leu Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys 
    130                 135                 140                 


Gln Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln 
145                 150                 155                 160 


Ser His Cys Ser Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met 
                165                 170                 175     


Gly Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro 
            180                 185                 190         


Gln Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met 
        195                 200                 205             


Leu Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly 
    210                 215                 220                 


Cys Leu Gln Leu Ser Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn 
225                 230                 235                 240 


Gln Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp 
                245                 250                 255     


Ala Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys 
            260                 265                 270         


Gly Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg 
        275                 280                 285             


Trp Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu 
    290                 295                 300                 


Arg Thr Thr Glu 
305             


<210>  3
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (Signal peptide, ECD)

<400>  3

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His 
625         


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130 (TM, ICD)

<400>  4

Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile 
            20                  25                  30          


Trp Pro Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser 
        35                  40                  45              


Pro His Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr 
    50                  55                  60                  


Ser Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn 
65                  70                  75                  80  


Asp Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys 
                85                  90                  95      


Lys Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser 
            100                 105                 110         


Ser Cys Met Ser Ser Ser Arg Pro Ser Ile Ser 
        115                 120             


<210>  5
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta ICD)

<400>  5

Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
1               5                   10                  15      


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            20                  25                  30          


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        35                  40                  45              


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    50                  55                  60                  


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
65                  70                  75                  80  


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                85                  90                  95      


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            100                 105                 110         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    130                 135                 140                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
145                 150                 155                 160 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                165                 170                 175     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            180                 185                 190         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205 


<210>  6
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (Signal peptide, ECD)

<400>  6

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His 
625         


<210>  7
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta (TM and ICD)

<400>  7

Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile 
            20                  25                  30          


Trp Pro Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser 
        35                  40                  45              


Pro His Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr 
    50                  55                  60                  


Ser Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn 
65                  70                  75                  80  


Asp Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys 
                85                  90                  95      


Lys Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser 
            100                 105                 110         


Ser Cys Met Ser Ser Ser Arg Pro Ser Ile Ser Ala Ser Leu Ser Ser 
        115                 120                 125             


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
    130                 135                 140                 


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr 
145                 150                 155                 160 


Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala 
                165                 170                 175     


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
            180                 185                 190         


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
        195                 200                 205             


Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly 
    210                 215                 220                 


Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val 
225                 230                 235                 240 


Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val 
                245                 250                 255     


Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu 
            260                 265                 270         


Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe 
        275                 280                 285             


Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala 
    290                 295                 300                 


Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
305                 310                 315                 320 


Gly Gln Asp Pro Thr His Leu Val 
                325             


<210>  8
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (Signal peptide, ECD)

<400>  8

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His 
625         


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R gamma (TM and ICD)

<400>  9

Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
            20                  25                  30          


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
        35                  40                  45              


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
    50                  55                  60                  


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
65                  70                  75                  80  


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
                85                  90                  95      


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            100                 105         


<210>  10
<211>  0
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Not Availabe

<400>  10
000
<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (Signal peptide)

<400>  11

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu 
            20                  


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GM-CSFR-alpha (Signal peptide)

<400>  12

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  13
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (Signal peptide, native sequence)

<400>  13
atggcaaggc tgggaaactg cagcctgact tgggctgccc tgatcatcct gctgctcccc       60

ggaagtctgg ag                                                           72


<210>  14
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GM-CSFR-alpha (Signal peptide, native sequence)

<400>  14
atgctgctgc tagtgacctc cctgctgctc tgtgagctgc ctcacccggc gttcctgctg       60

attcct                                                                  66


<210>  15
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ECD)

<400>  15

Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Arg Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Cys Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Cys Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Cys Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu Arg Ala Pro Thr Val Arg Leu Asp Thr Trp Trp Arg Gln 
305                 310                 315                 320 


Arg Gln Leu Asp Pro Arg Thr Val Gln Leu Phe Trp Lys Pro Val Pro 
                325                 330                 335     


Leu Glu Glu Asp Ser Gly Arg Ile Gln Gly Tyr Val Val Ser Trp Arg 
            340                 345                 350         


Pro Ser Gly Gln Ala Gly Ala Ile Leu Pro Leu Cys Asn Thr Thr Glu 
        355                 360                 365             


Leu Ser Cys Thr Phe His Leu Pro Ser Glu Ala Gln Glu Val Ala Leu 
    370                 375                 380                 


Val Ala Tyr Asn Ser Ala Gly Thr Ser Arg Pro Thr Pro Val Val Phe 
385                 390                 395                 400 


Ser Glu Ser Arg Gly Pro Ala Leu Thr Arg Leu His Ala Met Ala Arg 
                405                 410                 415     


Asp Pro His Ser Leu Trp Val Gly Trp Glu Pro Pro Asn Pro Trp Pro 
            420                 425                 430         


Gln Gly Tyr Val Ile Glu Trp Gly Leu Gly Pro Pro Ser Ala Ser Asn 
        435                 440                 445             


Ser Asn Lys Thr Trp Arg Met Glu Gln Asn Gly Arg Ala Thr Gly Phe 
    450                 455                 460                 


Leu Leu Lys Glu Asn Ile Arg Pro Phe Gln Leu Tyr Glu Ile Ile Val 
465                 470                 475                 480 


Thr Pro Leu Tyr Gln Asp Thr Met Gly Pro Ser Gln His Val Tyr Ala 
                485                 490                 495     


Tyr Ser Gln Glu Met Ala Pro Ser His Ala Pro Glu Leu His Leu Lys 
            500                 505                 510         


His Ile Gly Lys Thr Trp Ala Gln Leu Glu Trp Val Pro Glu Pro Pro 
        515                 520                 525             


Glu Leu Gly Lys Ser Pro Leu Thr His Tyr Thr Ile Phe Trp Thr Asn 
    530                 535                 540                 


Ala Gln Asn Gln Ser Phe Ser Ala Ile Leu Asn Ala Ser Ser Arg Gly 
545                 550                 555                 560 


Phe Val Leu His Gly Leu Glu Pro Ala Ser Leu Tyr His Ile His Leu 
                565                 570                 575     


Met Ala Ala Ser Gln Ala Gly Ala Thr Asn Ser Thr Val Leu Thr Leu 
            580                 585                 590         


Met Thr Leu Thr Pro Glu Gly Ser Glu Leu His 
        595                 600             


<210>  16
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ECD, native sequence)

<400>  16
gagtgcgggc acatcagtgt ctcagccccc atcgtccacc tgggggatcc catcacagcc       60

tcctgcatca tcaagcagaa ctgcagccat ctggacccgg agccacagat tctgtggaga      120

ctgggagcag agcttcagcc cgggggcagg cagcagcgtc tgtctgatgg gacccaggaa      180

tctatcatca ccctgcccca cctcaaccac actcaggcct ttctctcctg ctgcctgaac      240

tggggcaaca gcctgcagat cctggaccag gttgagctgc gcgcaggcta ccctccagcc      300

ataccccaca acctctcctg cctcatgaac ctcacaacca gcagcctcat ctgccagtgg      360

gagccaggac ctgagaccca cctacccacc agcttcactc tgaagagttt caagagccgg      420

ggcaactgtc agacccaagg ggactccatc ctggactgcg tgcccaagga cgggcagagc      480

cactgctgca tcccacgcaa acacctgctg ttgtaccaga atatgggcat ctgggtgcag      540

gcagagaatg cgctggggac cagcatgtcc ccacaactgt gtcttgatcc catggatgtt      600

gtgaaactgg agccccccat gctgcggacc atggacccca gccctgaagc ggcccctccc      660

caggcaggct gcctacagct gtgctgggag ccatggcagc caggcctgca cataaatcag      720

aagtgtgagc tgcgccacaa gccgcagcgt ggagaagcca gctgggcact ggtgggcccc      780

ctccccttgg aggcccttca gtatgagctc tgcgggctcc tcccagccac ggcctacacc      840

ctgcagatac gctgcatccg ctggcccctg cctggccact ggagcgactg gagccccagc      900

ctggagctga gaactaccga acgggccccc actgtcagac tggacacatg gtggcggcag      960

aggcagctgg accccaggac agtgcagctg ttctggaagc cagtgcccct ggaggaagac     1020

agcggacgga tccaaggtta tgtggtttct tggagaccct caggccaggc tggggccatc     1080

ctgcccctct gcaacaccac agagctcagc tgcaccttcc acctgccttc agaagcccag     1140

gaggtggccc ttgtggccta taactcagcc gggacctctc gtcccactcc ggtggtcttc     1200

tcagaaagca gaggcccagc tctgaccaga ctccatgcca tggcccgaga ccctcacagc     1260

ctctgggtag gctgggagcc ccccaatcca tggcctcagg gctatgtgat tgagtggggc     1320

ctgggccccc ccagcgcgag caatagcaac aagacctgga ggatggaaca gaatgggaga     1380

gccacggggt ttctgctgaa ggagaacatc aggccctttc agctctatga gatcatcgtg     1440

actcccttgt accaggacac catgggaccc tcccagcatg tctatgccta ctctcaagaa     1500

atggctccct cccatgcccc agagctgcat ctaaagcaca ttggcaagac ctgggcacag     1560

ctggagtggg tgcctgagcc ccctgagctg gggaagagcc cccttaccca ctacaccatc     1620

ttctggacca acgctcagaa ccagtccttc tccgccatcc tgaatgcctc ctcccgtggc     1680

tttgtcctcc atggcctgga gcccgccagt ctgtatcaca tccacctcat ggctgccagc     1740

caggctgggg ccaccaacag tacagtcctc accctgatga ccttgacccc agaggggtcg     1800

gagctacac                                                             1809


<210>  17
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ECD, 4 codons altered)

<400>  17
gagtgcgggc acatcagtgt ctcagccccc atcgtccacc tgggggatcc catcacagcc       60

tcctgcatca tcaagcagaa ctgcagccat ctggacccgg agccacagat tctgtggaga      120

ctgggagcag agcttcagcc cgggggcagg cagcagcgtc tgtctgatgg gacccaggaa      180

tctatcatca ccctgcccca cctcaaccac actcaggcct ttctctcctg ctgcctgaac      240

tggggcaaca gcctgcagat cctggaccag gttgagctgc gcgcaggcta ccctccagcc      300

ataccccaca acctctcctg cctcatgaac ctcacaacca gcagcctcat ctgccagtgg      360

gagccaggac ctgagaccca cctacccacc agcttcactc tgaagagttt caagagccgg      420

ggcaactgtc agacccaagg ggactccatc ctggactgcg tgcccaagga cgggcagagc      480

cactgctgca tcccacgcaa acacctgctg ttgtaccaga atatgggcat ctgggtgcag      540

gcagagaatg cgctggggac cagcatgtcc ccacaactgt gtcttgatcc catggatgtt      600

gtgaaactgg agccccccat gctgcggacc atggacccca gccctgaagc ggcccctccc      660

caggcaggct gcctacagct gtgctgggag ccatggcagc caggcctgca cataaatcag      720

aagtgtgagc tgcgccacaa gccgcagcgt ggagaagcca gctgggcact ggtgggcccc      780

ctccccttgg aggcccttca gtatgagctc tgcgggctcc tcccagccac ggcctacacc      840

ctgcagatac gctgcatccg ctggcccctg cctggccact ggagcgactg gagccccagc      900

ctggagctga gaactaccga acgggccccc actgtcagac tggacacatg gtggcggcag      960

aggcagctgg accccaggac agtgcagctg ttctggaagc cagtgcccct ggaggaagac     1020

agcggacgca tccaaggtta tgtggtttct tggagaccct caggccaggc tggggccatc     1080

ctgcccctct gcaacaccac agagctcagc tgcaccttcc acctgccttc agaagcccag     1140

gaggtggccc ttgtggccta taactcagcc gggacctctc gccccacccc ggtggtcttc     1200

tcagaaagca gaggcccagc tctgaccaga ctccatgcca tggcccgaga ccctcacagc     1260

ctctgggtag gctgggagcc ccccaatcca tggcctcagg gctatgtgat tgagtggggc     1320

ctgggccccc ccagcgcgag caatagcaac aagacctgga ggatggaaca gaatgggaga     1380

gccacggggt ttctgctgaa ggagaacatc aggccctttc agctctatga gatcatcgtg     1440

actcccttgt accaggacac catgggaccc tcccagcatg tctatgccta ctctcaagaa     1500

atggctccct cccatgcccc agagctgcat ctaaagcaca ttggcaagac ctgggcacag     1560

ctggagtggg tgcctgagcc ccctgagctg gggaagagcc cccttaccca ctacaccatc     1620

ttctggacca acgctcagaa ccagtccttc tccgccatcc tgaatgcatc ctcccgtggc     1680

tttgtcctcc atggcctgga gcccgccagt ctgtatcaca tccacctcat ggctgccagc     1740

caggctgggg ccaccaacag tacagtcctc accctgatga ccttgacccc agaggggtcg     1800

gagctacac                                                             1809


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (TM)

<400>  18

Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys 
1               5                   10                  15      


Gly Thr Ala Trp Leu Cys Cys 
            20              


<210>  19
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130 (TM)

<400>  19

Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe 
            20          


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (TM)

<400>  20

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2RG (TM)

<400>  21

Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu 
            20      


<210>  22
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (TM)

<400>  22
atcatcctgg gcctgttcgg cctcctgctg ttgctcacct gcctctgtgg aactgcctgg       60

ctctgttgc                                                               69


<210>  23
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gp130 (TM)

<400>  23
gccatagtcg tgcctgtttg cttagcattc ctattgacaa ctcttctggg agtgctgttc       60

tgcttt                                                                  66


<210>  24
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (TM)

<400>  24
attccgtggc tcggccacct cctcgtgggt ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210>  25
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2RG (TM)

<400>  25
gtggttatct ctgttggctc catgggattg attatcagcc ttctctgtgt gtatttctgg       60

ctg                                                                     63


<210>  26
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G2R-1)

<400>  26

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  27
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2RG (ICD, G2R-1)

<400>  27

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  28
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130 (ICD, G2R-2)

<400>  28

Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser 
            100     


<210>  29
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G2R-2)

<400>  29

Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
1               5                   10                  15      


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            20                  25                  30          


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        35                  40                  45              


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    50                  55                  60                  


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
65                  70                  75                  80  


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                85                  90                  95      


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            100                 105                 110         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    130                 135                 140                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
145                 150                 155                 160 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                165                 170                 175     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            180                 185                 190         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205 


<210>  30
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G2R-3)

<400>  30

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210>  31
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G2R-3)

<400>  31

Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala 
        35                  40                  45              


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
    50                  55                  60                  


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
65                  70                  75                  80  


Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro 
                85                  90                  95      


Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu 
            100                 105                 110         


Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro 
        115                 120                 125             


Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu 
    130                 135                 140                 


Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val 
145                 150                 155                 160 


Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu 
                165                 170                 175     


Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
            180                 185                 190         


Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200         


<210>  32
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G12R-1)

<400>  32

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr 
65          


<210>  33
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12Rb2 (ICD, G12R-1)

<400>  33

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
            20                  25                  30          


Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His 
        35                  40                  45              


Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys 
    50                  55                  60                  


Met Arg Cys Asp Ser Leu Met Leu 
65                  70          


<210>  34
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21R-1)

<400>  34

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr 
65          


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R (ICD, G21R-1)

<400>  35

Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
1               5                   10                  15      


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala 
            20                  25                  


<210>  36
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21R-2)

<400>  36

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn 
    50                  55                  60              


<210>  37
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R (ICD, G21R-2)

<400>  37

Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr 
1               5                   10                  15      


Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro 
            20                  25                  30          


Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp 
        35                  40                  45              


Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu 
    50                  55                  60                  


Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser 
65                  70                  75                  80  


Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro 
                85                  90                  95      


Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly 
            100                 105                 110         


Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala 
        115                 120                 125             


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys 
    130                 135                 140                 


Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro 
145                 150                 155                 160 


Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser 
                165                 170                 175     


Ser Pro Gly Pro Gln Ala Ser 
            180             


<210>  38
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21/2R-1)

<400>  38

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 
                85                  90              


<210>  39
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G21/2R-1)

<400>  39

Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala 
        35                  40                  45              


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
    50                  55                  60                  


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
65                  70                  75                  80  


Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro 
                85                  90                  95      


Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu 
            100                 105                 110         


Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro 
        115                 120                 125             


Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu 
    130                 135                 140                 


Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val 
145                 150                 155                 160 


Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu 
                165                 170                 175     


Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
            180                 185                 190         


Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200         


<210>  40
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G12/2R-1)

<400>  40

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210>  41
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G12/2R-1)

<400>  41

Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
        35                  40              


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12Rb2 (ICD, G12/2R-1)

<400>  42

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser 
            20  


<210>  43
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb  (ICD, G12/2R-1)

<400>  43

Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly 
1               5                   10                  15      


Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp 
            20                  25                  30          


Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val 
        35                  40                  45              


Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu 
    50                  55                  60                  


Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg 
65                  70                  75                  80  


Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
                85                  90                  95      


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            100                 105                 110         


Thr His Leu Val 
        115     


<210>  44
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21/12/2R-1)

<400>  44

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 
                85                  90              


<210>  45
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G21/12/2R-1)

<400>  45

Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
        35                  40              


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12Rb2 (ICD, G21/12/2R-1)

<400>  46

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser 
            20  


<210>  47
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G21/12/2R-1)

<400>  47

Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly 
1               5                   10                  15      


Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp 
            20                  25                  30          


Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val 
        35                  40                  45              


Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu 
    50                  55                  60                  


Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg 
65                  70                  75                  80  


Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
                85                  90                  95      


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            100                 105                 110         


Thr His Leu Val 
        115     


<210>  48
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130 (ICD, G27/2R-1)

<400>  48

Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            100                 105                 110         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        115                 120                 125             


Gln Val Pro Ser Val Gln Val Phe Ser Arg 
    130                 135             


<210>  49
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G27/2R-1)

<400>  49

Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
1               5                   10                  15      


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            20                  25                  30          


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        35                  40                  45              


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    50                  55                  60                  


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
65                  70                  75                  80  


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                85                  90                  95      


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            100                 105                 110         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    130                 135                 140                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
145                 150                 155                 160 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                165                 170                 175     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            180                 185                 190         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu 
        195                 200                 


<210>  50
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G7R-1)

<400>  50

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210>  51
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7Ra (ICD, G7R-1)

<400>  51

Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
            20                  25                  30          


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
        35                  40                  45              


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
    50                  55                  60                  


Gln Asn Gln 
65          


<210>  52
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21/7R-1)

<400>  52

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 
                85                  90              


<210>  53
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL7R (ICD, G21/7R-1)

<400>  53

Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
1               5                   10                  15      


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
            20                  25                  30          


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
        35                  40                  45              


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
    50                  55                  60                  


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
65                  70                  75          


<210>  54
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2RB (ICD, G2R-1)

<400>  54
aactgcagga acaccgggcc atggctgaag aaggtcctga agtgtaacac cccagacccc       60

tcgaagttct tttcccagct gagctcagag catggaggag acgtccagaa gtggctctct      120

tcgcccttcc cctcatcgtc cttcagccct ggcggcctgg cacctgagat ctcgccacta      180

gaagtgctgg agagggacaa ggtgacgcag ctgctcctgc agcaggacaa ggtgcctgag      240

cccgcatcct taagcagcaa ccactcgctg accagctgct tcaccaacca gggttacttc      300

ttcttccacc tcccggatgc cttggagata gaggcctgcc aggtgtactt tacttacgac      360

ccctactcag aggaagaccc tgatgagggt gtggccgggg cacccacagg gtcttccccc      420

caacccctgc agcctctgtc aggggaggac gacgcctact gcaccttccc ctccagggat      480

gacctgctgc tcttctcccc cagtctcctc ggtggcccca gccccccaag cactgcccct      540

gggggcagtg gggccggtga agagaggatg cccccttctt tgcaagaaag agtccccaga      600

gactgggacc cccagcccct ggggcctccc accccaggag tcccagacct ggtggatttt      660

cagccacccc ctgagctggt gctgcgagag gctggggagg aggtccctga cgctggcccc      720

agggagggag tcagtttccc ctggtccagg cctcctgggc agggggagtt cagggccctt      780

aatgctcgcc tgcccctgaa cactgatgcc tacttgtccc tccaagaact ccagggtcag      840

gacccaactc acttggtgta g                                                861


<210>  55
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2RG (ICD, G2R-1)

<400>  55

Gly Ala Ala Cys Gly Gly Ala Cys Gly Ala Thr Gly Cys Cys Cys Cys 
1               5                   10                  15      


Gly Ala Ala Thr Thr Cys Cys Cys Ala Cys Cys Cys Thr Gly Ala Ala 
            20                  25                  30          


Gly Ala Ala Cys Cys Thr Ala Gly Ala Gly Gly Ala Thr Cys Thr Thr 
        35                  40                  45              


Gly Thr Thr Ala Cys Thr Gly Ala Ala Thr Ala Cys Cys Ala Cys Gly 
    50                  55                  60                  


Gly Gly Ala Ala Cys Thr Thr Thr Thr Cys Gly Gly Cys Cys Thr Gly 
65                  70                  75                  80  


Gly Ala Gly Thr Gly Gly Thr Gly Thr Gly Thr Cys Thr Ala Ala Gly 
                85                  90                  95      


Gly Gly Ala Cys Thr Gly Gly Cys Thr Gly Ala Gly Ala Gly Thr Cys 
            100                 105                 110         


Thr Gly Cys Ala Gly Cys Cys Ala Gly Ala Cys Thr Ala Cys Ala Gly 
        115                 120                 125             


Thr Gly Ala Ala Cys Gly Ala Cys Thr Cys Thr Gly Cys Cys Thr Cys 
    130                 135                 140                 


Gly Thr Cys Ala Gly Thr Gly Ala Gly Ala Thr Thr Cys Cys Cys Cys 
145                 150                 155                 160 


Cys Ala Ala Ala Ala Gly Gly Ala Gly Gly Gly Gly Cys Cys Cys Thr 
                165                 170                 175     


Thr Gly Gly Gly Gly Ala Gly Gly Gly Gly Cys Cys Thr Gly Gly Gly 
            180                 185                 190         


Gly Cys Cys Thr Cys Cys Cys Cys Ala Thr Gly Cys Ala Ala Cys Cys 
        195                 200                 205             


Ala Gly Cys Ala Thr Ala Gly Cys Cys Cys Cys Thr Ala Cys Thr Gly 
    210                 215                 220                 


Gly Gly Cys Cys Cys Cys Cys Cys Cys Ala Thr Gly Thr Thr Ala Cys 
225                 230                 235                 240 


Ala Cys Cys Cys Thr Ala Ala Ala Gly Cys Cys Thr Gly Ala Ala Ala 
                245                 250                 255     


Cys Cys Thr Gly Ala 
            260     


<210>  56
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gp130 (ICD, G2R-2)

<400>  56
aataagcgag acctaattaa aaaacacatc tggcctaatg ttccagatcc ttcaaagagt       60

catattgccc agtggtcacc tcacactcct ccaaggcaca attttaattc aaaagatcaa      120

atgtattcag atggcaattt cactgatgta agtgttgtgg aaatagaagc aaatgacaaa      180

aagccttttc cagaagatct gaaatcattg gacctgttca aaaaggaaaa aattaatact      240

gaaggacaca gcagtggtat tggggggtct tcatgtatgt catcttctag gccaagcatt      300

tct                                                                    303


<210>  57
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G2R-2)

<400>  57
gcatccttaa gcagcaacca ctcgctgacc agctgcttca ccaaccaggg ttacttcttc       60

ttccacctcc cggatgcctt ggagatagag gcctgccagg tgtactttac ttacgacccc      120

tactcagagg aagaccctga tgagggtgtg gccggggcac ccacagggtc ttccccccaa      180

cccctgcagc ctctgtcagg ggaggacgac gcctactgca ccttcccctc cagggatgac      240

ctgctgctct tctcccccag tctcctcggt ggccccagcc ccccaagcac tgcccctggg      300

ggcagtgggg ccggtgaaga gaggatgccc ccttctttgc aagaaagagt ccccagagac      360

tgggaccccc agcccctggg gcctcccacc ccaggagtcc cagacctggt ggattttcag      420

ccaccccctg agctggtgct gcgagaggct ggggaggagg tccctgacgc tggccccagg      480

gagggagtca gtttcccctg gtccaggcct cctgggcagg gggagttcag ggcccttaat      540

gctcgcctgc ccctgaacac tgatgcctac ttgtccctcc aagaactcca gggtcaggac      600

ccaactcact tggtgtag                                                    618


<210>  58
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G2R-3)

<400>  58
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccat                                                                 186


<210>  59
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G2R-3)

<400>  59
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccctg atgagggtgt ggccggggca cccacagggt cttcccccca acccctgcag      180

cctctgtcag gggaggacga cgcctactgc accttcccct ccagggatga cctgctgctc      240

ttctccccca gtctcctcgg tggccccagc cccccaagca ctgcccctgg gggcagtggg      300

gccggtgaag agaggatgcc cccttctttg caagaaagag tccccagaga ctgggacccc      360

cagcccctgg ggcctcccac cccaggagtc ccagacctgg tggattttca gccaccccct      420

gagctggtgc tgcgagaggc tggggaggag gtccctgacg ctggccccag ggagggagtc      480

agtttcccct ggtccaggcc tcctgggcag ggggagttca gggcccttaa tgctcgcctg      540

cccctgaaca ctgatgccta cttgtccctc caagaactcc agggtcagga cccaactcac      600

ttggtgtag                                                              609


<210>  60
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G12R-1)

<400>  60
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac c                                                201


<210>  61
<211>  219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12Rb2 (ICD, G12R-1)

<400>  61
gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga cctcccctca       60

catgaggcac ctctcgctga ctctctggaa gaactggagc ctcagcacat ctccctttct      120

gttttcccct caagttctct tcacccactc accttctcct gtggtgataa gctgactctg      180

gatcagttaa agatgaggtg tgactccctc atgctctga                             219


<210>  62
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21R-1)

<400>  62
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac c                                                201


<210>  63
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-21R (ICD, G21R-1)

<400>  63
agccctgggg acgaaggacc cccccggagc tacctccgcc agtgggtggt cattcctccg       60

ccactttcga gccctggacc ccaggccagc taa                                    93


<210>  64
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21R-2)

<400>  64
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataac                                                              189


<210>  65
<211>  549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-21R (ICD, G21R-2)

<400>  65
cagaactcgg ggggctcagc ttacagtgag gagagggatc ggccatacgg cctggtgtcc       60

attgacacag tgactgtgct agatgcagag gggccatgca cctggccctg cagctgtgag      120

gatgacggct acccagccct ggacctggat gctggcctgg agcccagccc aggcctagag      180

gacccactct tggatgcagg gaccacagtc ctgtcctgtg gctgtgtctc agctggcagc      240

cctgggctag gagggcccct gggaagcctc ctggacagac taaagccacc ccttgcagat      300

ggggaggact gggctggggg actgccctgg ggtggccggt cacctggagg ggtctcagag      360

agtgaggcgg gctcacccct ggccggcctg gatatggaca cgtttgacag tggctttgtg      420

ggctctgact gcagcagccc tgtggagtgt gacttcacca gccctgggga cgaaggaccc      480

ccccggagct acctccgcca gtgggtggtc attcctccgc cactttcgag ccctggaccc      540

caggccagc                                                              549


<210>  66
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21/2R-1)

<400>  66
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac ctgtggcctc cccactctgg tccagaccta tgtgctccag      240

ggggacccaa gagcagtttc cacccagccc caatcccag                             279


<210>  67
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G21/2R-1)

<400>  67
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccctg atgagggtgt ggccggggca cccacagggt cttcccccca acccctgcag      180

cctctgtcag gggaggacga cgcctactgc accttcccct ccagggatga cctgctgctc      240

ttctccccca gtctcctcgg tggccccagc cccccaagca ctgcccctgg gggcagtggg      300

gccggtgaag agaggatgcc cccttctttg caagaaagag tccccagaga ctgggacccc      360

cagcccctgg ggcctcccac cccaggagtc ccagacctgg tggattttca gccaccccct      420

gagctggtgc tgcgagaggc tggggaggag gtccctgacg ctggccccag ggagggagtc      480

agtttcccct ggtccaggcc tcctgggcag ggggagttca gggcccttaa tgctcgcctg      540

cccctgaaca ctgatgccta cttgtccctc caagaactcc agggtcagga cccaactcac      600

ttggtgtag                                                              609


<210>  68
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G12/2R-1)

<400>  68
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccat                                                                 186


<210>  69
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G12/2R-1)

<400>  69
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccct                                                              129


<210>  70
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12Rb2 (ICD, G12/2R-1)

<400>  70
gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga cctcccctca       60


<210>  71
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G12/2R-1)

<400>  71
ggtggcccca gccccccaag cactgcccct gggggcagtg gggccggtga agagaggatg       60

cccccttctt tgcaagaaag agtccccaga gactgggacc cccagcccct ggggcctccc      120

accccaggag tcccagacct ggtggatttt cagccacccc ctgagctggt gctgcgagag      180

gctggggagg aggtccctga cgctggcccc agggagggag tcagtttccc ctggtccagg      240

cctcctgggc agggggagtt cagggccctt aatgctcgcc tgcccctgaa cactgatgcc      300

tacttgtccc tccaagaact ccagggtcag gacccaactc acttggtgta g               351


<210>  72
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21/12/2R-1)

<400>  72
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac ctgtggcctc cccactctgg tccagaccta tgtgctccag      240

ggggacccaa gagcagtttc cacccagccc caatcccag                             279


<210>  73
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G21/12/2R-1)

<400>  73
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccct                                                              129


<210>  74
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-12Rb2 (ICD, G21/12/2R-1)

<400>  74
gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga cctcccctca       60


<210>  75
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G21/12/2R-1)

<400>  75
ggtggcccca gccccccaag cactgcccct gggggcagtg gggccggtga agagaggatg       60

cccccttctt tgcaagaaag agtccccaga gactgggacc cccagcccct ggggcctccc      120

accccaggag tcccagacct ggtggatttt cagccacccc ctgagctggt gctgcgagag      180

gctggggagg aggtccctga cgctggcccc agggagggag tcagtttccc ctggtccagg      240

cctcctgggc agggggagtt cagggccctt aatgctcgcc tgcccctgaa cactgatgcc      300

tacttgtccc tccaagaact ccagggtcag gacccaactc acttggtgta g               351


<210>  76
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gp130 (ICD, G27/2R-1)

<400>  76
aataagcgag acctaattaa aaaacacatc tggcctaatg ttccagatcc ttcaaagagt       60

catattgccc agtggtcacc tcacactcct ccaaggcaca atttcaattc aaaggatcaa      120

atgtattcag atggcaattt cactgatgta agtgttgtgg aaatagaagc aaatgacaaa      180

aagccttttc cagaagatct gaaatcattg gacctgttca aaaaggaaaa aattaatact      240

gaaggacaca gcagtggtat tggggggtct tcatgtatgt catcttctag gccaagcatt      300

tctagcagtg atgaaaatga atcttcacaa aacacttcga gcactgtcca gtattctacc      360

gtggtacaca gtggctacag acaccaagtt ccgtcagtcc aagtcttctc aaga            414


<210>  77
<211>  618
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2Rb (ICD, G27/2R-1)

<400>  77
gcatccttaa gcagcaacca ctcgctgacc agctgcttca ccaaccaggg ttacttcttc       60

ttccacctcc cggatgcctt ggagatagag gcctgccagg tgtactttac ttacgacccc      120

tactcagagg aagaccctga tgagggtgtg gccggggcac ccacagggtc ttccccccaa      180

cccctgcagc ctctgtcagg ggaggacgac gcctactgca ccttcccctc cagggatgac      240

ctgctgctct tctcccccag tctcctcggt ggccccagcc ccccaagcac tgcccctggg      300

ggcagtgggg ccggtgaaga gaggatgccc ccttctttgc aagaaagagt ccccagagac      360

tgggaccccc agcccctggg gcctcccacc ccaggagtcc cagacctggt ggattttcag      420

ccaccccctg agctggtgct gcgagaggct ggggaggagg tccctgacgc tggccccagg      480

gagggagtca gtttcccctg gtccaggcct cctgggcagg gggagttcag ggcccttaat      540

gctcgcctgc ccctgaacac tgatgcctac ttgtccctcc aagaactcca gggtcaggac      600

ccaactcact tggtgtag                                                    618


<210>  78
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G7R-1)

<400>  78
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccat                                                                 186


<210>  79
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-7Ra (ICD, G7R-1)

<400>  79
agtggcaaga atgggcctca tgtgtaccag gacctcctgc ttagccttgg gactacaaac       60

agcacgctgc cccctccatt ttctctccaa tctggaatcc tgacattgaa cccagttgct      120

cagggtcagc ccattcttac ttccctggga tcaaatcaag aagaagcata tgtcaccatg      180

tccagcttct accaaaacca gtga                                             204


<210>  80
<211>  279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-CSFR (ICD, G21/7R-1)

<400>  80
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac ctgtggcctc cccactctgg tccagaccta tgtgctccag      240

ggggacccaa gagcagtttc cacccagccc caatcccag                             279


<210>  81
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL7R (ICD, G21/7R-1)

<400>  81
tcctcttcca ggtccctaga ctgcagggag agtggcaaga atgggcctca tgtgtaccag       60

gacctcctgc ttagccttgg gactacaaac agcacgctgc cccctccatt ttctctccaa      120

tctggaatcc tgacattgaa cccagttgct cagggtcagc ccattcttac ttccctggga      180

tcaaatcaag aagaagcata tgtcaccatg tccagcttct accaaaacca gtga            234


<210>  82
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT G-CSF

<400>  82

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  83
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  130a1 variant with mutation

<400>  83

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Arg Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Lys Asp Val Ala 
            100                 105                 110         


Arg Phe Ala Thr Thr Ile Trp Gln Gln Met Lys Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  84
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  307 variant with mutation

<400>  84

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Glu Phe Leu Leu 
1               5                   10                  15      


Asp Cys Leu Lys Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Arg Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  85
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT G-CSFR

<400>  85

Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Arg Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Ser Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Ser Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Ser Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu 
305         


<210>  86
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  134 G-CSFR variant

<400>  86

Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Glu Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Ser Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Glu Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Ser Ile Pro Asp Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Ser Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu 
305         


<210>  87
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  307 G-CSFR variant

<400>  87

Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Glu Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Ser Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Ser Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Lys Pro Met Lys Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Ser Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Glu Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu 
305         


<210>  88
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT G-CSFR

<400>  88

Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys 
1               5                   10                  15      


Gly Thr Ala Trp Leu Cys Cys 
            20              


<210>  89
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT G-CSFR

<400>  89

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu 
            20                  


<210>  90
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G2R-3 (G-CSFR)

<400>  90

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210>  91
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G2R-3 (IL-2R beta)

<400>  91

Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala 
        35                  40                  45              


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
    50                  55                  60                  


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
65                  70                  75                  80  


Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro 
                85                  90                  95      


Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu 
            100                 105                 110         


Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro 
        115                 120                 125             


Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu 
    130                 135                 140                 


Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val 
145                 150                 155                 160 


Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu 
                165                 170                 175     


Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
            180                 185                 190         


Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200         


<210>  92
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4R (IL4R alfa)

<400>  92

Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
1               5                   10                  15      


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            20                  25                  30          


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        35                  40                  45              


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    50                  55                  60                  


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
65                  70                  75                  80  


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                85                  90                  95      


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            100                 105                 110         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        115                 120                 125             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    130                 135                 140                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
145                 150                 155                 160 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                165                 170                 175     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            180                 185                 190         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        195                 200                 205             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    210                 215                 220                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
225                 230                 235                 240 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                245                 250                 255     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            260                 265                 270         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        275                 280                 285             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    290                 295                 300                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
305                 310                 315                 320 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                325                 330                 335     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            340                 345                 350         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        355                 360                 365             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    370                 375                 380                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
385                 390                 395                 400 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                405                 410                 415     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            420                 425                 430         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        435                 440                 445             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    450                 455                 460                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
465                 470                 475                 480 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                485                 490                 495     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            500                 505 


<210>  93
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G6R (gp130)

<400>  93

Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            100                 105                 110         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        115                 120                 125             


Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
    130                 135                 140                 


Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp His 
145                 150                 155                 160 


Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                165                 170                 175     


Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu Arg 
            180                 185                 190         


Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu Lys 
        195                 200                 205             


Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln Met 
    210                 215                 220                 


Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala Thr 
                245                 250                 255     


Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            260                 265                 270         


Gly Tyr Met Pro Gln 
        275         


<210>  94
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GEPOR

<400>  94

His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser Pro 
1               5                   10                  15      


Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe Gln 
            20                  25                  30          


Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys Thr 
        35                  40                  45              


Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu Arg 
    50                  55                  60                  


Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu Gly 
65                  70                  75                  80  


Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr Leu 
                85                  90                  95      


Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp Leu 
            100                 105                 110         


Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly Ser 
        115                 120                 125             


Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro Glu 
    130                 135                 140                 


Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser Ser 
145                 150                 155                 160 


Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr Pro 
                165                 170                 175     


Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile Ser 
            180                 185                 190         


Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu Ser 
        195                 200                 205             


Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala Ala 
    210                 215                 220                 


Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
225                 230                 235 


<210>  95
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIFNAR2 (G-CSFR)

<400>  95

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser 
65  


<210>  96
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIFNAR2 (IFNAR2)

<400>  96

Lys Lys Lys Val Trp Asp Tyr Asn Tyr Asp Asp Glu Ser Asp Ser Asp 
1               5                   10                  15      


Thr Glu Ala Ala Pro Arg Thr Ser Gly Gly Gly Tyr Thr Met His Gly 
            20                  25                  30          


Leu Thr Val Arg Pro Leu Gly Gln Ala Ser Ala Thr Ser Thr Glu Ser 
        35                  40                  45              


Gln Leu Ile Asp Pro Glu Ser Glu Glu Glu Pro Asp Leu Pro Glu Val 
    50                  55                  60                  


Asp Val Glu Leu Pro Thr Met Pro Lys Asp Ser Pro Gln Gln Leu Glu 
65                  70                  75                  80  


Leu Leu Ser Gly Pro Cys Glu Arg Arg Lys Ser Pro Leu Gln Asp Pro 
                85                  90                  95      


Phe Pro Glu Glu Asp Tyr Ser Ser Thr Glu Gly Ser Gly Gly Arg Ile 
            100                 105                 110         


Thr Phe Asn Val Asp Leu Asn Ser Val Phe Leu Arg Val Leu Asp Asp 
        115                 120                 125             


Glu Asp Ser Asp Asp Leu Glu Ala Pro Leu Met Leu Ser Ser His Leu 
    130                 135                 140                 


Glu Glu Met Val Asp Pro Glu Asp Pro Asp Asn Val Gln Ser Asn His 
145                 150                 155                 160 


Leu Leu Ala Ser Gly Glu Gly Thr Gln Pro Thr Phe Pro Ser Pro Ser 
                165                 170                 175     


Ser Glu Gly Leu Trp Ser Glu Asp Ala Pro Ser Asp Gln Ser Asp Thr 
            180                 185                 190         


Ser Glu Ser Asp Val Asp Leu Gly Asp Gly Tyr Ile Met Arg 
        195                 200                 205     


<210>  97
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIFNGR1 (IFN Gamma R2)

<400>  97

Lys Tyr Arg Gly Leu Ile Lys Tyr Trp Phe His Thr Pro Pro Ser Ile 
1               5                   10                  15      


Pro Leu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Thr Gln Pro Ile Leu 
            20                  25                  30          


Glu Ala Leu Asp Lys Asp Ser Ser Pro Lys Asp Asp Val Trp Asp Ser 
        35                  40                  45              


Val Ser Ile Ile Ser Phe Pro Glu Lys Glu Gln Glu Asp Val Leu Gln 
    50                  55                  60                  


Thr Leu 
65      


<210>  98
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIFNGR1 (IFN Gamma R1)

<400>  98

Glu Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly 
1               5                   10                  15      


Tyr Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser 
            20                  25                  30      


<210>  99
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIFNGR2 (G-CSFR)

<400>  99

Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


<210>  100
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GIFNGR2 (IFN Gamma R1)

<400>  100

Thr Glu Gly Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe 
1               5                   10                  15      


Gly Tyr Asp Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser 
            20                  25                  30          


<210>  101
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-CSFR(Ig-CRH)

<400>  101

Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Arg Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Ser Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Ser Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Ser Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu 
305         


<210>  102
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL-18

<400>  102

Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      


Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          


Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              


Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  


Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  


Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      


Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         


Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             


Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 


His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 


Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     


Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         


Asp 
    


<210>  103
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCXCL13

<400>  103

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  104
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL-21

<400>  104

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  105
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCCL3

<400>  105

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210>  106
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCCL4

<400>  106

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  107
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCCL19

<400>  107

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  108
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIFN Gamma

<400>  108

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  109
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIFN alfa -1/13

<400>  109

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  110
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIL-17

<400>  110

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  111
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta/IL-15R beta

<400>  111

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  112
<211>  369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R Gamma c

<400>  112

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  113
<211>  825
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4R alfa

<400>  113

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  114
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-9R

<400>  114

Met Gly Leu Gly Arg Cys Ile Trp Glu Gly Trp Thr Leu Glu Ser Glu 
1               5                   10                  15      


Ala Leu Arg Arg Asp Met Gly Thr Trp Leu Leu Ala Cys Ile Cys Ile 
            20                  25                  30          


Cys Thr Cys Val Cys Leu Gly Val Ser Val Thr Gly Glu Gly Gln Gly 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Thr Cys Leu Thr Asn Asn Ile Leu Arg Ile 
    50                  55                  60                  


Asp Cys His Trp Ser Ala Pro Glu Leu Gly Gln Gly Ser Ser Pro Trp 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Gln Ala Pro Gly Gly Thr His Lys Cys Ile 
                85                  90                  95      


Leu Arg Gly Ser Glu Cys Thr Val Val Leu Pro Pro Glu Ala Val Leu 
            100                 105                 110         


Val Pro Ser Asp Asn Phe Thr Ile Thr Phe His His Cys Met Ser Gly 
        115                 120                 125             


Arg Glu Gln Val Ser Leu Val Asp Pro Glu Tyr Leu Pro Arg Arg His 
    130                 135                 140                 


Val Lys Leu Asp Pro Pro Ser Asp Leu Gln Ser Asn Ile Ser Ser Gly 
145                 150                 155                 160 


His Cys Ile Leu Thr Trp Ser Ile Ser Pro Ala Leu Glu Pro Met Thr 
                165                 170                 175     


Thr Leu Leu Ser Tyr Glu Leu Ala Phe Lys Lys Gln Glu Glu Ala Trp 
            180                 185                 190         


Glu Gln Ala Gln His Arg Asp His Ile Val Gly Val Thr Trp Leu Ile 
        195                 200                 205             


Leu Glu Ala Phe Glu Leu Asp Pro Gly Phe Ile His Glu Ala Arg Leu 
    210                 215                 220                 


Arg Val Gln Met Ala Thr Leu Glu Asp Asp Val Val Glu Glu Glu Arg 
225                 230                 235                 240 


Tyr Thr Gly Gln Trp Ser Glu Trp Ser Gln Pro Val Cys Phe Gln Ala 
                245                 250                 255     


Pro Gln Arg Gln Gly Pro Leu Ile Pro Pro Trp Gly Trp Pro Gly Asn 
            260                 265                 270         


Thr Leu Val Ala Val Ser Ile Phe Leu Leu Leu Thr Gly Pro Thr Tyr 
        275                 280                 285             


Leu Leu Phe Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn 
    290                 295                 300                 


Val Pro Ser Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn 
305                 310                 315                 320 


Gly Asn Phe Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu 
                325                 330                 335     


Ser Gln Asp Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val 
            340                 345                 350         


Gln Glu Ala Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys 
        355                 360                 365             


Ser Val Ala Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro 
    370                 375                 380                 


Gly Asn Leu Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp 
385                 390                 395                 400 


Arg Val Gln Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr 
                405                 410                 415     


Ser Leu Thr Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys 
        435                 440                 445             


Tyr Gly Gly Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser 
    450                 455                 460                 


Gly Pro Ile Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly 
465                 470                 475                 480 


Leu Glu Thr Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln 
                485                 490                 495     


Arg Pro Gly Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val 
            500                 505                 510         


Leu Ser Lys Ala Arg Ser Trp Thr Phe 
        515                 520     


<210>  115
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12R breta2

<400>  115

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         


<210>  116
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R

<400>  116

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  117
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  117

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210>  118
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  118

Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys 
1               5                   10                  15      


Thr Leu Glu His Leu 
            20      


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  119

Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe 
1               5                   10                  15      


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  120

Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln 
1               5                   10                  15      


<210>  121
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta

<400>  121

Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
1               5                   10                  15      


Phe Phe Ser Gln Leu 
            20      


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta

<400>  122

Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr 
1               5                   10                  15      


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta

<400>  123

Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp 
1               5                   10                  15      


Ala 
    


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta

<400>  124

Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R Gamma c

<400>  125

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


<210>  126
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R Gamma c

<400>  126

Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys 
1               5                   10                  15      


<210>  127
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4R alfa

<400>  127

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala 
            20  


<210>  128
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4R alfa

<400>  128

Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg Asp 
1               5                   10                  15      


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4R alfa

<400>  129

Leu Val Ile Ala Gly Asn Pro Ala Tyr Arg Ser Phe Ser Asn Ser Leu 
1               5                   10                  15      


Ser 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4R alfa

<400>  130

Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser Leu Leu 
1               5                   10                  15      


Ala 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-4R alfa

<400>  131

Gly Ala Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile 
1               5                   10                  15      


Pro 
    


<210>  132
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-9R

<400>  132

Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn Val Pro Ser Pro Ala 
1               5                   10                  15      


Met Phe Phe Gln Pro 
            20      


<210>  133
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-9R

<400>  133

Gly Ala His Gly Ala Gly Val Leu Leu Ser Gln Asp Cys Ala Gly Thr 
1               5                   10                  15      


<210>  134
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-9R

<400>  134

Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val Gln Glu Ala Thr Ala 
1               5                   10                  15      


<210>  135
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-12R beta2

<400>  135

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
            20                  25      


<210>  136
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R

<400>  136

Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro Glu Arg 
1               5                   10                  15      


Phe Phe Met Pro Leu 
            20      


<210>  137
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R

<400>  137

Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu Val 
1               5                   10                  15      


<210>  138
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R

<400>  138

Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His Pro Pro Arg 
1               5                   10                  15      


<210>  139
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-21R

<400>  139

Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile 
1               5                   10                  15      


Pro 
    


<210>  140
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  140

Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro Ser Lys 
1               5                   10                  15      


Ser His Ile Ala Gln 
            20      


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  141

Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp 
1               5                   10                  15      


<210>  142
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  142

Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly 
1               5                   10                  15      


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  143

Ser Thr Val Val His Ser Gly Tyr Arg His Gln Val Pro Ser Val Gln 
1               5                   10                  15      


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  144

Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln 
1               5                   10                  15      


His Glu Ser Ser 
            20  


<210>  145
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  145

Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
1               5                   10                  


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gp130

<400>  146

Thr Val Arg Gln Gly Gly Tyr Met Pro Gln 
1               5                   10  


<210>  147
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV 16 E7eTCR (LVL-modified chimeric TCR)

<400>  147

Met Ala Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Trp Arg Gly Gly Arg Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr Thr 
            340                 345                 350         


Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly Ala 
        355                 360                 365             


Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly Leu 
    370                 375                 380                 


Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser Tyr 
385                 390                 395                 400 


Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe Leu 
                405                 410                 415     


Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln Met 
            420                 425                 430         


Lys Asp Ser Ala Ser Tyr Leu Cys Ala Ser Val Asp Gly Asn Asn Arg 
        435                 440                 445             


Leu Ala Phe Gly Lys Gly Asn Gln Val Val Val Ile Pro Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  148
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV 16 E7eTCR (Cys-substituted, LVL-modified chimeric TCR)

<400>  148

Met Ala Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Trp Arg Gly Gly Arg Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr Thr 
            340                 345                 350         


Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly Ala 
        355                 360                 365             


Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly Leu 
    370                 375                 380                 


Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser Tyr 
385                 390                 395                 400 


Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe Leu 
                405                 410                 415     


Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln Met 
            420                 425                 430         


Lys Asp Ser Ala Ser Tyr Leu Cys Ala Ser Val Asp Gly Asn Asn Arg 
        435                 440                 445             


Leu Ala Phe Gly Lys Gly Asn Gln Val Val Val Ile Pro Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  149
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1eTCR (NY-ESO-1c259 TCR a chain)


<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  Xaa = Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  Xaa = Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  Xaa = Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  Xaa = Pyrrolysine

<400>  149

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gly Leu Gly Trp 
1               5                   10                  15      


Val Ser Ser Lys Gly Glu Val Thr Gly Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gly Trp Phe Arg Gly Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gly Ser Ser Gly Arg Glu Gly Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gly Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Xaa Asn Pro Asp Pro Ala Val Tyr Xaa 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Xaa Thr Asn Val Ser Xaa Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Cys Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  150
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1eTCR (NY-ESO-1 c259 TCR b chain)


<220>
<221>  MISC_FEATURE
<222>  (244)..(244)
<223>  Xaa = Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (252)..(252)
<223>  Xaa = Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (272)..(272)
<223>  Xaa = Pyrrolysine

<220>
<221>  MISC_FEATURE
<222>  (273)..(273)
<223>  Xaa = Pyrrolysine

<400>  150

Arg Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp 
1               5                   10                  15      


Ala Gly Pro Val Asn Ala Gly Val Thr Gly Thr Pro Lys Phe Gly Val 
            20                  25                  30          


Leu Lys Thr Gly Gly Ser Met Thr Leu Gly Cys Ala Gly Asp Met Asn 
        35                  40                  45              


His Glu Tyr Met Ser Trp Tyr Arg Gly Asp Pro Gly Met Gly Leu Arg 
    50                  55                  60                  


Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gly Gly Glu Val 
65                  70                  75                  80  


Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu 
                85                  90                  95      


Arg Leu Leu Ser Ala Ala Pro Ser Gly Thr Ser Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Cys Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gly Pro Leu Lys Glu Gly Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gly Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gly Val Gly Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Xaa Asp Arg Ala Lys Pro Val Thr Xaa Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Xaa 
            260                 265                 270         


Xaa Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  151
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (CTL019)

<400>  151

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Ile His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Ile Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  152
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (Leader)

<400>  152

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  153
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (VH)

<400>  153

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Ile His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  154
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (Linker)

<400>  154

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  155
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (VL)

<400>  155

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  156
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (CD8 hinge)

<400>  156

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  157
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (CD8 TM)

<400>  157

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  158
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (4-1BB)

<400>  158

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  159
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation 4-1BB containing anti-CD19 CAR (CD3 Zeta)

<400>  159

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  160
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CAR (P4-z)

<400>  160

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser 
        35                  40                  45              


Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln 
    50                  55                  60                  


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser 
65                  70                  75                  80  


Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile 
                85                  90                  95      


Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val 
            100                 105                 110         


Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser 
            180                 185                 190         


Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys 
    210                 215                 220                 


Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala 
225                 230                 235                 240 


Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp 
                245                 250                 255     


Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe 
            260                 265                 270         


Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala Ser Thr Thr Thr Pro 
        275                 280                 285             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Arg Pro Leu 
    290                 295                 300                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
305                 310                 315                 320 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                325                 330                 335     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            340                 345                 350         


Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Asn 
        355                 360                 365             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    370                 375                 380                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
385                 390                 395                 400 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  161
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (Leader)

<400>  161

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro 
            20                  25                  30          


Gly Leu 
        


<210>  162
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (VH)

<400>  162

Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
1               5                   10                  15      


Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro 
            20                  25                  30          


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp 
        35                  40                  45              


Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro 
    50                  55                  60                  


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
65                  70                  75                  80  


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr 
                85                  90                  95      


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


Gly Ile Leu 
        115 


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (Linker)

<400>  163

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  164
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (VL)

<400>  164

Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro 
            20                  25                  30          


Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu 
            100                 105                 110         


Thr Val Leu Ser Ala Ser 
        115             


<210>  165
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (CD8 hinge)

<400>  165

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Arg Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  166
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (CD8 TM)

<400>  166

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  167
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  First generation anti-mesothelin CARb (CD3 Zeta)

<400>  167

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Asn Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Asn Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  168
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR 
       (HN1scFv-28Z)

<400>  168

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Ala Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys 
        35                  40                  45              


Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser 
65                  70                  75                  80  


Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr 
                85                  90                  95      


Asn Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr 
            100                 105                 110         


Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly 
        115                 120                 125             


Asp Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile 
            260                 265                 270         


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
        275                 280                 285             


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
    290                 295                 300                 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  169
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (Leader)

<400>  169

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln 
            20                  25  


<210>  170
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (VH)

<400>  170

Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr 
            20                  25                  30          


Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  171
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (Linker)

<400>  171

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  172
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (VL)

<400>  172

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  173
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (CD8 hinge)

<400>  173

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40          


<210>  174
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (CD8 TM)

<400>  174

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  175
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (CD28 ICD)

<400>  175

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  176
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Second generation CD28 containing anti-mesothelin CAR (CD3 zeta)

<400>  176

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  177
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (HN1scFv-28BBZ)

<400>  177

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Ala Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys 
        35                  40                  45              


Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser 
65                  70                  75                  80  


Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr 
                85                  90                  95      


Asn Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr 
            100                 105                 110         


Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly 
        115                 120                 125             


Asp Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         


Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val 
385                 390                 395                 400 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        435                 440                 445             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    450                 455                 460                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
465                 470                 475                 480 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                485                 490                 495     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            500                 505                 510         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        515                 520                 525             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    530                 535                 540                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 


<210>  178
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (Leader)

<400>  178

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln 
            20                  25  


<210>  179
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (VH)

<400>  179

Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr 
            20                  25                  30          


Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  180
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (Linker)

<400>  180

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  181
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (VL)

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  182
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (CD28 hinge)

<400>  182

Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              


His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    50                  55              


<210>  183
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (CD28 TM)

<400>  183

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            20                  25              


<210>  184
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (CD28 ICD)

<400>  184

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  185
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (4-1BB)

<400>  185

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  186
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Third generation CD28 and 4-1BB containing anti-mesothelin CAR 
       (CD3 zeta)

<400>  186

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  187
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  187

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Ile Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
    210                 215                 


<210>  188
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  188

Pro Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu 
1               5                   10                  15      


Leu Val Ile Leu Ala Cys Val Leu Trp 
            20                  25  


<210>  189
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  189

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  190
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7R alfa

<400>  190

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly 
            20  


<210>  191
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-7

<400>  191

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His 
145                 150         


<210>  192
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/2R-1 (IL-2R?)

<400>  192

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  193
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/2R-2 (IL-7R alfa)

<400>  193

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly 
    50                  55              


<210>  194
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/2R-2 (IL-2R beta)

<400>  194

Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val 
1               5                   10                  15      


Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe 
            20                  25                  30          


Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile 
        35                  40                  45              


Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp 
    50                  55                  60                  


Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro 
65                  70                  75                  80  


Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser 
                85                  90                  95      


Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser 
            100                 105                 110         


Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met 
        115                 120                 125             


Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro 
    130                 135                 140                 


Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro 
145                 150                 155                 160 


Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala 
                165                 170                 175     


Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln 
            180                 185                 190         


Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala 
        195                 200                 205             


Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
    210                 215                 220                 


<210>  195
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/2/12R-1 (IL-12R beta2)

<400>  195

Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro 
1               5                   10                  15      


Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser 
            20                  25                  30          


Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser 
        35                  40                  45              


Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu 
    50                  55                  60                  


Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
65                  70                  75      


<210>  196
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/12/2R-1 (IL-2R beta)

<400>  196

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
        115                 120                 125         


<210>  197
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/12/2R-1 (IL-12R beta2)

<400>  197

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser 
            20  


<210>  198
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/12/2R-1 (IL-2R beta)

<400>  198

Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly 
1               5                   10                  15      


Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp 
            20                  25                  30          


Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val 
        35                  40                  45              


Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu 
    50                  55                  60                  


Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg 
65                  70                  75                  80  


Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
                85                  90                  95      


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            100                 105                 110         


Thr His Leu Val 
        115     


<210>  199
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/12/2R-2 (IL-7R alfa)

<400>  199

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg 
    50              


<210>  200
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/12/2R-2 (IL-12R beta2)

<400>  200

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
            20                  25                  30          


Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His 
        35                  40                  45              


Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys 
    50                  55                  60                  


Met Arg Cys 
65          


<210>  201
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/21-R1 (IL-21R)

<400>  201

Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro Glu Arg 
1               5                   10                  15      


Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe Lys Lys Trp 
            20                  25                  30          


Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly Pro Trp Ser 
        35                  40                  45              


Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His Pro Pro Arg 
    50                  55                  60                  


Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu 
65                  70                  75                  80  


Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala 
                85                  90                  95      


Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr 
            100                 105                 110         


Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro 
        115                 120                 125             


Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp 
    130                 135                 140                 


Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu 
145                 150                 155                 160 


Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser 
                165                 170                 175     


Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro 
            180                 185                 190         


Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly 
        195                 200                 205             


Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala 
    210                 215                 220                 


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys 
225                 230                 235                 240 


Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro 
                245                 250                 255     


Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser 
            260                 265                 270         


Ser Pro Gly Pro Gln Ala Ser 
        275                 


<210>  202
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/21-R2 (IL-7R alfa)

<400>  202

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp 
    50                  


<210>  203
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/21-R2 (7/21-R2)

<400>  203

Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala 
1               5                   10                  15      


Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr 
            20                  25                  30          


Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 
        35                  40                  45              


Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly 
    50                  55                  60                  


Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu 
65                  70                  75                  80  


Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu 
                85                  90                  95      


Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly 
            100                 105                 110         


Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys 
        115                 120                 125             


Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly 
    130                 135                 140                 


Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu 
145                 150                 155                 160 


Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp 
                165                 170                 175     


Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly 
            180                 185                 190         


Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu 
        195                 200                 205             


Ser Ser Pro Gly Pro Gln Ala Ser 
    210                 215     


<210>  204
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/21/7R-1 (IL-7R alfa)

<400>  204

Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu 
1               5                   10                  15      


Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser 
            20                  25                  30          


Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro 
        35                  40                  45              


Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met 
    50                  55                  60                  


Ser Ser Phe Tyr Gln Asn Gln 
65                  70      


<210>  205
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/7/21R-1 (IL-7R alfa)

<400>  205

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  206
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/7/21R-1 (IL-21R)

<400>  206

Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
1               5                   10                  15      


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
            20                  25                  30  


<210>  207
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/2/21/12R-1 (IL-21R)

<400>  207

Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
1               5                   10                  15      


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala 
            20                  25                  


<210>  208
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/2/21/12R-1 (IL-12R beta2)

<400>  208

Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
            20                  25                  30          


Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His 
        35                  40                  45              


Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys 
    50                  55                  60                  


Met Arg Cys Asp Ser Leu Met 
65                  70      


<210>  209
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/4R-1 (IL-4R alfa)

<400>  209

Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
1               5                   10                  15      


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
            20                  25                  30          


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
        35                  40                  45              


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
    50                  55                  60                  


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
65                  70                  75                  80  


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
                85                  90                  95      


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
            100                 105                 110         


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
        115                 120                 125             


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
    130                 135                 140                 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
                165                 170                 175     


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
            180                 185                 190         


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
        195                 200                 205             


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
    210                 215                 220                 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
225                 230                 235                 240 


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
                245                 250                 255     


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
            260                 265                 270         


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
        275                 280                 285             


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
    290                 295                 300                 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
305                 310                 315                 320 


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
                325                 330                 335     


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
            340                 345                 350         


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
        355                 360                 365             


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
    370                 375                 380                 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
385                 390                 395                 400 


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
                405                 410                 415     


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
            420                 425                 430         


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
        435                 440                 445             


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
    450                 455                 460                 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
465                 470                 475                 480 


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
                485                 490                 495     


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
            500                 505                 510         


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
        515                 520                 525             


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
    530                 535                 540                 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
545                 550                 555                 560 


Val Gly Pro Thr Tyr Met Arg Val Ser 
                565                 


<210>  210
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/4R-2 (IL-7R alfa)

<400>  210

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala 
    50          


<210>  211
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/4R-2 (IL-4R alfa)

<400>  211

Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
1               5                   10                  15      


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            20                  25                  30          


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        35                  40                  45              


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    50                  55                  60                  


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
65                  70                  75                  80  


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                85                  90                  95      


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            100                 105                 110         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        115                 120                 125             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    130                 135                 140                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
145                 150                 155                 160 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                165                 170                 175     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            180                 185                 190         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        195                 200                 205             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    210                 215                 220                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
225                 230                 235                 240 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                245                 250                 255     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            260                 265                 270         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        275                 280                 285             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    290                 295                 300                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
305                 310                 315                 320 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                325                 330                 335     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            340                 345                 350         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        355                 360                 365             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    370                 375                 380                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
385                 390                 395                 400 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                405                 410                 415     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            420                 425                 430         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        435                 440                 445             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    450                 455                 460                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
465                 470                 475                 480 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                485                 490                 495     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            500                 505 


<210>  212
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/6R-1 (Gp130)

<400>  212

Lys Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
1               5                   10                  15      


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            20                  25                  30          


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        35                  40                  45              


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    50                  55                  60                  


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
65                  70                  75                  80  


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                85                  90                  95      


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            100                 105                 110         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        115                 120                 125             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    130                 135                 140                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
145                 150                 155                 160 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                165                 170                 175     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            180                 185                 190         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        195                 200                 205             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    210                 215                 220                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                245                 250                 255     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            260                 265                 270         


Gly Gly Tyr Met Pro Gln 
        275             


<210>  213
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/6R-2 (IL-7R alfa)

<400>  213

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu 
    50                  55          


<210>  214
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7/6R-2 (Gp130)

<400>  214

Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys 
1               5                   10                  15      


Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser 
            20                  25                  30          


Cys Met Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu 
        35                  40                  45              


Ser Ser Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His 
    50                  55                  60                  


Ser Gly Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser 
65                  70                  75                  80  


Glu Ser Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu 
                85                  90                  95      


Gln Leu Val Asp His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln 
            100                 105                 110         


Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile 
        115                 120                 125             


Ser His Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp 
    130                 135                 140                 


Phe Val Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys 
145                 150                 155                 160 


Gly Ser Gly Gln Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala 
                165                 170                 175     


Phe Gly Pro Gly Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly 
            180                 185                 190         


Met Glu Ala Ala Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln 
        195                 200                 205             


Thr Val Arg Gln Gly Gly Tyr Met Pro Gln 
    210                 215             


<210>  215
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hTNF- alfa

<400>  215

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  216
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hNKG2-D: ICD-TM-ECD

<400>  216

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  217
<211>  4758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR_P2A_G12-2R1-134_T2A_hIL-18

<400>  217
cccgccagga tcctgacgcg tatggtgctg ctggtcacca gcttactcct gtgcgagctc       60

ccccatcctg cgttcttgct gatccccgac atccagcagg tgcagctgca acagtcgggc      120

cccgagttag aaaaacccgg cgcctccgtg aagatctcgt gtaaagcttc gggctactcg      180

tttaccggct acaccatgaa ttgggttaag cagagccatg gaaagtctct tgaatggata      240

ggcctgatta cgccttataa tggggcctcg agctacaacc agaaatttcg tggtaaggca      300

actctgactg tagacaagtc gtcctccacc gcatacatgg atcttctgag cctaacctca      360

gaagacagcg cagtctactt ctgcgcccgt ggtggttacg atggccgcgg attcgactat      420

tggggccagg gcaccaccgt caccgtgagc tccggcggtg gcgggtccgg tggcggcggc      480

tcaagcggag gaggtagtga catcgagttg acccagtcgc ctgccatcat gtccgcatcc      540

cccggcgaga aggtgacgat gacgtgttct gcttccagct ctgtatcgta catgcactgg      600

taccaacaga agtccggcac ctcccccaag cgttggatct acgacacttc caagctggcg      660

tctggcgtcc ctgggcgctt ttcaggtagc gggtccggca atagctattc cttgacgatc      720

agtagcgtgg aggctgagga tgatgccacc tactactgcc agcagtggag caagcacccg      780

ctcaccttcg gcgccgggac caagcttgaa atcaaggcgg cggcgatcga ggtgatgtat      840

cctcctccct acctggacaa cgagaaatcc aatggcacta tcatccacgt gaaggggaag      900

cacctgtgcc cgagccccct gttccccggc ccttccaagc ctttttgggt gcttgttgtg      960

gtcggcggcg tgctggcctg ctactctctg ctggtaaccg tagcgttcat catcttctgg     1020

gtgcgatcta agcggtcccg gctgttgcac agtgactaca tgaacatgac cccgcgccgc     1080

cccggcccaa cccgcaagca ctaccagccg tacgctccac ctcgcgactt tgccgcctac     1140

aggtcgcgag tgaaattttc gcgctccgcg gacgcgccgg cctatcagca gggccagaac     1200

cagctttaca acgagttgaa cctcgggcgc agggaggagt acgacgtgct ggataaacgt     1260

agaggtcggg acccggagat gggcggcaaa ccacgccgca agaaccctca ggaaggcctg     1320

tacaacgagc tccagaagga caaaatggct gaggcgtact cggagattgg gatgaaaggc     1380

gagcggcgcc gcggcaaggg ccacgatggc ctgtaccagg ggctatctac cgctacaaag     1440

gacacctacg acgccctaca tatgcaggcc ctgccaccgc gtggctctgg cgcaaccaac     1500

ttctcgcttc tgaagcaggc cggtgatgtg gaggaaaacc caggtcctat ggcccgcctg     1560

ggcaactgct cgctgacctg ggcggccctg atcatcctgc tgctgcccgg ctctctggag     1620

gagtgtggcc atatttccgt gtcagctcca atcgtgcacc tgggcgaccc catcaccgct     1680

tcttgcatca tcaagcagaa ctgctctcac ctcgaccctg agccccaaat actttgggag     1740

ctgggcgcgg agctccagcc tggaggacgc cagcagcgtt tgtcagacgg cactcaggaa     1800

tccatcatca ccctcccaca tctgaatcac acccaggcgt tcctgtcttg ttgtctcaac     1860

tggggcaact ccttgcagat actggaccag gtggagctga gagctggcta tcccccggca     1920

attcctcaca acctgtcctg tctgatgaac ctgaccacct ccagtctgat ctgtcagtgg     1980

gagcccgggc cagagactca ccttcccacc agcttcaccc ttaagtcgtt caaatccgag     2040

ggcaactgcc agacccaggg tgattctatt ttggattgcg tgcccaagga cgggcagtct     2100

cactgttgta ttcccgacaa gcacctcctt ttataccaga atatgggcat ctgggtgcag     2160

gccgagaatg ccctgggaac gtctatgtct ccacagctat gcctggatcc aatggacgta     2220

gtgaagctgg agccccccat gctacgcact atggatccta gcccagaggc cgctccccct     2280

caggcggggt gcctgcagct ttgttgggaa ccctggcaac ccgggttgca cattaaccag     2340

aagtgcgagc tgcgccacaa gccccagaga ggagaggcct cctgggccct cgtgggccct     2400

ctgccgttgg aggccttgca gtatgagctg tgcggcctct tgcccgctac agcttatact     2460

ctgcaaatca ggtgtattcg ctggcctttg cccggacact ggtccgactg gtcccccagc     2520

cttgagctga gaaccacgga gcgcgccccc accgtacgct tggacacctg gtggcgccag     2580

aggcagctgg accctcgcac tgtgcagctg ttctggaagc cggtgcccct ggaggaggac     2640

tccggacgca tccagggcta cgtggtcagc tggcgtccga gtgggcaggc cggggccatc     2700

ctgcccctgt gcaacacgac tgagctgagc tgcactttcc atctgcccag cgaggctcag     2760

gaggtggcgc tcgtggctta caactccgca ggcacttctc gcccaacccc cgtggtgttc     2820

tctgagagtc ggggccccgc cctgacgcgc cttcacgcca tggcgcgcga cccgcattcc     2880

ctttgggtcg gttgggagcc acctaaccca tggccgcagg gctacgtgat cgagtggggc     2940

ctgggccccc cgagcgcatc gaacagcaac aagacctgga gaatggaaca gaacggccgc     3000

gcaaccggct tcctattaaa ggagaacatc cgcccgttcc agctgtacga gatcatcgtg     3060

acaccgctgt accaggacac tatggggcct tctcagcacg tttacgccta ctcccaggag     3120

atggccccga gccacgcacc ggaactgcac ctaaagcaca tcggtaagac ctgggcacag     3180

ctcgagtggg tccccgagcc tcccgagcta ggcaagtcgc cgctgaccca ttacaccatc     3240

ttctggacca acgcgcagaa ccagtccttt agcgcgatcc tcaatgcctc ctcccgcggt     3300

ttcgtcttgc acgggctgga gccagcctcc ttataccaca tccacctgat ggcggcttcc     3360

caggctggtg ctaccaacag cacagttttg acactgatga ccctgacccc cgagggctcg     3420

gagctccaca tcattttggg actcttcgga ctgctgctgc tgctgacctg cctgtgcggc     3480

actgcttggc tctgctgttc tcccaaccgc aagaaccctc tttggccctc tgtccctgac     3540

ccggcccatt ctagcctggg atcttgggtc ccgaccatca tggaagaaga cgcgttccag     3600

ctccctgggc tgggcacccc tccgatcacg aagctcacgg tcctggagga ggacgagaag     3660

aagcccgtac cgtgggagag ccactcctcg aatcatagcc taacctcctg ctttacaaac     3720

caggggtatt tttttttcca cttgcccgac gctctggaga tcgaggcctg ccaggtgtac     3780

ttcacctacg acccctacag cgaggaggac cctgccggtg atctgcccac ccatgacggc     3840

tatctgccat caaacattga cgacctgccg tccggaggtc ccagtcctcc gtccaccgcc     3900

cccggcggtt ctggtgccgg cgaagaacgg atgcctccct ccctgcagga gcgtgtgcca     3960

cgggattggg acccacagcc cttagggccg cctacccccg gcgtgcccga cctcgtcgat     4020

ttccagccgc ctcctgagct ggttctccga gaggcaggag aggaggtgcc tgatgctgga     4080

ccccgtgagg gcgtgagctt tccttggtct cgcccgccag gacaggggga gttccgtgct     4140

ctcaacgcgc gtctgccgtt gaacactgat gcatacctca gtcttcagga gctgcagggc     4200

caggatccaa cccacctcgt tggctcaggg gaaggtcgcg gctcgctgtt gacgtgtggt     4260

gacgtggagg agaaccccgg cccgtacttc ggtaagctgg agtctaaact gtcggtgata     4320

cggaacctga acgaccaggt cctgttcatt gaccagggta accgcccgct gttcgaggac     4380

atgactgact ccgattgccg cgacaatgcc ccccgcacga tcttcattat ctccatgtac     4440

aaggatagcc aaccccgtgg tatggccgtg accattagcg tcaaatgtga gaagatctct     4500

actctgtcct gtgagaataa gattatctcc ttcaaggaga tgaacccccc tgataacatc     4560

aaagacacta aatcggacat cattttcttt cagaggagcg tgccaggcca cgacaacaag     4620

atgcagttcg agagttctag ttacgaggga tatttcctgg cctgcgaaaa agaacgtgac     4680

ctcttcaagc taatcctgaa gaaggaggac gagctcggtg acaggagcat catgtttact     4740

gtccaaaacg aggactga                                                   4758


<210>  218
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' upstream sequence including Kozak

<400>  218
cccgccagga tcctgacgcg t                                                 21


<210>  219
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mesothelin CAR

<400>  219
atggtgctgc tggtcaccag cttactcctg tgcgagctcc cccatcctgc gttcttgctg       60

atccccgaca tccagcaggt gcagctgcaa cagtcgggcc ccgagttaga aaaacccggc      120

gcctccgtga agatctcgtg taaagcttcg ggctactcgt ttaccggcta caccatgaat      180

tgggttaagc agagccatgg aaagtctctt gaatggatag gcctgattac gccttataat      240

ggggcctcga gctacaacca gaaatttcgt ggtaaggcaa ctctgactgt agacaagtcg      300

tcctccaccg catacatgga tcttctgagc ctaacctcag aagacagcgc agtctacttc      360

tgcgcccgtg gtggttacga tggccgcgga ttcgactatt ggggccaggg caccaccgtc      420

accgtgagct ccggcggtgg cgggtccggt ggcggcggct caagcggagg aggtagtgac      480

atcgagttga cccagtcgcc tgccatcatg tccgcatccc ccggcgagaa ggtgacgatg      540

acgtgttctg cttccagctc tgtatcgtac atgcactggt accaacagaa gtccggcacc      600

tcccccaagc gttggatcta cgacacttcc aagctggcgt ctggcgtccc tgggcgcttt      660

tcaggtagcg ggtccggcaa tagctattcc ttgacgatca gtagcgtgga ggctgaggat      720

gatgccacct actactgcca gcagtggagc aagcacccgc tcaccttcgg cgccgggacc      780

aagcttgaaa tcaaggcggc ggcgatcgag gtgatgtatc ctcctcccta cctggacaac      840

gagaaatcca atggcactat catccacgtg aaggggaagc acctgtgccc gagccccctg      900

ttccccggcc cttccaagcc tttttgggtg cttgttgtgg tcggcggcgt gctggcctgc      960

tactctctgc tggtaaccgt agcgttcatc atcttctggg tgcgatctaa gcggtcccgg     1020

ctgttgcaca gtgactacat gaacatgacc ccgcgccgcc ccggcccaac ccgcaagcac     1080

taccagccgt acgctccacc tcgcgacttt gccgcctaca ggtcgcgagt gaaattttcg     1140

cgctccgcgg acgcgccggc ctatcagcag ggccagaacc agctttacaa cgagttgaac     1200

ctcgggcgca gggaggagta cgacgtgctg gataaacgta gaggtcggga cccggagatg     1260

ggcggcaaac cacgccgcaa gaaccctcag gaaggcctgt acaacgagct ccagaaggac     1320

aaaatggctg aggcgtactc ggagattggg atgaaaggcg agcggcgccg cggcaagggc     1380

cacgatggcc tgtaccaggg gctatctacc gctacaaagg acacctacga cgccctacat     1440

atgcaggccc tgccaccgcg t                                               1461


<210>  220
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  220
ggctctggcg caaccaactt ctcgcttctg aagcaggccg gtgatgtgga ggaaaaccca       60

ggtcct                                                                  66


<210>  221
<211>  2673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G12/2R-1 134 ECD

<400>  221
atggcccgcc tgggcaactg ctcgctgacc tgggcggccc tgatcatcct gctgctgccc       60

ggctctctgg aggagtgtgg ccatatttcc gtgtcagctc caatcgtgca cctgggcgac      120

cccatcaccg cttcttgcat catcaagcag aactgctctc acctcgaccc tgagccccaa      180

atactttggg agctgggcgc ggagctccag cctggaggac gccagcagcg tttgtcagac      240

ggcactcagg aatccatcat caccctccca catctgaatc acacccaggc gttcctgtct      300

tgttgtctca actggggcaa ctccttgcag atactggacc aggtggagct gagagctggc      360

tatcccccgg caattcctca caacctgtcc tgtctgatga acctgaccac ctccagtctg      420

atctgtcagt gggagcccgg gccagagact caccttccca ccagcttcac ccttaagtcg      480

ttcaaatccg agggcaactg ccagacccag ggtgattcta ttttggattg cgtgcccaag      540

gacgggcagt ctcactgttg tattcccgac aagcacctcc ttttatacca gaatatgggc      600

atctgggtgc aggccgagaa tgccctggga acgtctatgt ctccacagct atgcctggat      660

ccaatggacg tagtgaagct ggagcccccc atgctacgca ctatggatcc tagcccagag      720

gccgctcccc ctcaggcggg gtgcctgcag ctttgttggg aaccctggca acccgggttg      780

cacattaacc agaagtgcga gctgcgccac aagccccaga gaggagaggc ctcctgggcc      840

ctcgtgggcc ctctgccgtt ggaggccttg cagtatgagc tgtgcggcct cttgcccgct      900

acagcttata ctctgcaaat caggtgtatt cgctggcctt tgcccggaca ctggtccgac      960

tggtccccca gccttgagct gagaaccacg gagcgcgccc ccaccgtacg cttggacacc     1020

tggtggcgcc agaggcagct ggaccctcgc actgtgcagc tgttctggaa gccggtgccc     1080

ctggaggagg actccggacg catccagggc tacgtggtca gctggcgtcc gagtgggcag     1140

gccggggcca tcctgcccct gtgcaacacg actgagctga gctgcacttt ccatctgccc     1200

agcgaggctc aggaggtggc gctcgtggct tacaactccg caggcacttc tcgcccaacc     1260

cccgtggtgt tctctgagag tcggggcccc gccctgacgc gccttcacgc catggcgcgc     1320

gacccgcatt ccctttgggt cggttgggag ccacctaacc catggccgca gggctacgtg     1380

atcgagtggg gcctgggccc cccgagcgca tcgaacagca acaagacctg gagaatggaa     1440

cagaacggcc gcgcaaccgg cttcctatta aaggagaaca tccgcccgtt ccagctgtac     1500

gagatcatcg tgacaccgct gtaccaggac actatggggc cttctcagca cgtttacgcc     1560

tactcccagg agatggcccc gagccacgca ccggaactgc acctaaagca catcggtaag     1620

acctgggcac agctcgagtg ggtccccgag cctcccgagc taggcaagtc gccgctgacc     1680

cattacacca tcttctggac caacgcgcag aaccagtcct ttagcgcgat cctcaatgcc     1740

tcctcccgcg gtttcgtctt gcacgggctg gagccagcct ccttatacca catccacctg     1800

atggcggctt cccaggctgg tgctaccaac agcacagttt tgacactgat gaccctgacc     1860

cccgagggct cggagctcca catcattttg ggactcttcg gactgctgct gctgctgacc     1920

tgcctgtgcg gcactgcttg gctctgctgt tctcccaacc gcaagaaccc tctttggccc     1980

tctgtccctg acccggccca ttctagcctg ggatcttggg tcccgaccat catggaagaa     2040

gacgcgttcc agctccctgg gctgggcacc cctccgatca cgaagctcac ggtcctggag     2100

gaggacgaga agaagcccgt accgtgggag agccactcct cgaatcatag cctaacctcc     2160

tgctttacaa accaggggta tttttttttc cacttgcccg acgctctgga gatcgaggcc     2220

tgccaggtgt acttcaccta cgacccctac agcgaggagg accctgccgg tgatctgccc     2280

acccatgacg gctatctgcc atcaaacatt gacgacctgc cgtccggagg tcccagtcct     2340

ccgtccaccg cccccggcgg ttctggtgcc ggcgaagaac ggatgcctcc ctccctgcag     2400

gagcgtgtgc cacgggattg ggacccacag cccttagggc cgcctacccc cggcgtgccc     2460

gacctcgtcg atttccagcc gcctcctgag ctggttctcc gagaggcagg agaggaggtg     2520

cctgatgctg gaccccgtga gggcgtgagc tttccttggt ctcgcccgcc aggacagggg     2580

gagttccgtg ctctcaacgc gcgtctgccg ttgaacactg atgcatacct cagtcttcag     2640

gagctgcagg gccaggatcc aacccacctc gtt                                  2673


<210>  222
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  222
ggctcagggg aaggtcgcgg ctcgctgttg acgtgtggtg acgtggagga gaaccccggc       60

ccg                                                                     63


<210>  223
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-18

<400>  223
tacttcggta agctggagtc taaactgtcg gtgatacgga acctgaacga ccaggtcctg       60

ttcattgacc agggtaaccg cccgctgttc gaggacatga ctgactccga ttgccgcgac      120

aatgcccccc gcacgatctt cattatctcc atgtacaagg atagccaacc ccgtggtatg      180

gccgtgacca ttagcgtcaa atgtgagaag atctctactc tgtcctgtga gaataagatt      240

atctccttca aggagatgaa cccccctgat aacatcaaag acactaaatc ggacatcatt      300

ttctttcaga ggagcgtgcc aggccacgac aacaagatgc agttcgagag ttctagttac      360

gagggatatt tcctggcctg cgaaaaagaa cgtgacctct tcaagctaat cctgaagaag      420

gaggacgagc tcggtgacag gagcatcatg tttactgtcc aaaacgagga ctga            474


<210>  224
<211>  3213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G12-2R1_134_ECD_T2A_hIL-18

<400>  224
atggctcgcc tcggaaattg ttccctgacc tgggcagcat tgatcattct cctgctacca       60

gggagtctcg aagaatgtgg ccatatctct gtaagcgccc ctattgtgca cttgggagac      120

ccaatcacag catcatgcat catcaagcag aattgctctc atctcgatcc agagccacag      180

atactctggg agctgggcgc agaactgcaa cccggagggc gccagcagag actgagtgat      240

ggaacacagg agagcattat cactttacct catctgaacc acacccaggc ctttcttagc      300

tgctgtttga actggggcaa cagtctccag attctggacc aggtggagct gagggcgggt      360

tacccgcccg ccattccaca caatttgtcc tgtctcatga acctgacaac aagtagcctg      420

atatgccagt gggagccagg gccggagacc catctcccaa ctagtttcac gctcaagagc      480

ttcaagtcag aggggaactg ccagacacaa ggggacagca ttctcgactg tgtgcccaag      540

gacgggcaga gtcactgttg cattccagac aagcatctgc tgctgtatca gaacatgggc      600

atttgggttc aggccgaaaa tgccctcggt acttccatga gtccacagtt gtgtcttgac      660

cccatggatg tggtgaagct ggaaccgcca atgctgagga ccatggatcc ctcacctgag      720

gctgctccgc cacaggcagg gtgtctgcag ctgtgctggg agccctggca gcctggattg      780

cacataaacc aaaaatgtga gctgaggcac aagccccaga gaggtgaggc gagttgggcc      840

ctggtagggc ctcttcctct agaagccctg cagtatgaat tgtgtggatt acttcccgca      900

accgcctaca ctcttcagat caggtgtatc cggtggcctc tgcccggcca ctggagcgac      960

tggtctccga gcctcgaatt gagaacaaca gaacgggctc ctacggtgcg tctggataca     1020

tggtggaggc agcgacagtt ggacccgcgt acagtgcagc tgttctggaa gcccgtacct     1080

ctggaagagg atagtggtcg gattcaggga tatgtggtct cttggcggcc ttccggtcag     1140

gctggggcta tccttccctt atgcaacact acagagctca gctgtacctt tcatttaccc     1200

agcgaagccc aggaagtggc tctcgtcgcc tataattccg ctggaacgtc aagacccacc     1260

cctgtcgtgt tctctgagtc tcggggacct gccctaacca ggctccatgc aatggcacgc     1320

gatcctcaca gtctgtgggt tggctgggaa ccaccaaatc cctggcctca gggctatgtc     1380

atcgaatggg gccttggccc cccatcagcc tccaatagca acaagacctg gagaatggag     1440

caaaatggga gagcaaccgg gttcctgctg aaggagaaca tccgaccgtt ccagctttat     1500

gaaattattg taactccact gtaccaggac acaatgggac catctcagca tgtctacgct     1560

tattcccagg agatggcgcc tagtcatgct cctgaattac acttgaagca catagggaaa     1620

acttgggccc aattagagtg ggtcccggag cctcccgagc tggggaaaag cccattgacc     1680

cattacacga tattttggac caatgctcag aaccaatcct tttctgccat cctgaatgcc     1740

tcatctcgag gctttgtgct gcatggccta gagcctgcat cactctacca cattcacctg     1800

atggccgcca gccaggcggg tgccacaaac tccacagttc tcactttaat gactctaacc     1860

ccagagggca gtgaactgca catcatatta gggttattcg gattgctgct tcttttgact     1920

tgcctctgtg gcactgcgtg gctgtgctgc tccccgaacc gaaagaatcc tctctggcct     1980

agcgttcccg atcctgctca cagttcacta ggatcatggg tgccaaccat catggaagag     2040

gatgccttcc agctaccagg actgggtacg ccgcccataa ccaaattaac ggtccttgaa     2100

gaggatgaga agaaaccagt tccatgggaa agccactctt ccaatcatag cctcacctct     2160

tgcttcacca accaagggta tttttttttc cacctgcccg acgctctgga aattgaggcc     2220

tgccaagtgt atttcaccta cgacccttac tctgaagaag atccggcagg cgacctaccc     2280

actcatgatg gctacctgcc gtcaaacatc gacgacttac cgagtggagg accctcccca     2340

ccttctacag cccctggtgg ctccggtgca ggggaggaaa ggatgcctcc ctcactgcag     2400

gagagagtcc ccagagactg ggatcctcag ccacttggac cacccacacc tggtgtgcct     2460

gaccttgtgg attttcagcc ccctcctgag cttgttcttc gagaagcagg tgaggaggtt     2520

cctgatgcag gcccacgtga gggggtctcc tttccctggt ccaggcctcc tggccaagga     2580

gagttccgcg ctctgaatgc acgcttgcct ctgaacacag atgcttacct gagcctacaa     2640

gagttacaag gccaggatcc gacacacctg gtgggatctg gcgagggtag aggcagcctc     2700

ctaacttgtg gcgacgtgga ggagaacccc ggtccctact tcggtaagct ggagtctaaa     2760

ctgtcggtga tacggaacct gaacgaccag gtcctgttca ttgaccaggg taaccgcccg     2820

ctgttcgagg acatgactga ctccgattgc cgcgacaatg ccccccgcac gatcttcatt     2880

atctccatgt acaaggatag ccaaccccgt ggtatggccg tgaccattag cgtcaaatgt     2940

gagaagatct ctactctgtc ctgtgagaat aagattatct ccttcaagga gatgaacccc     3000

cctgataaca tcaaagacac taaatcggac atcattttct ttcagaggag cgtgccaggc     3060

cacgacaaca agatgcagtt cgagagttct agttacgagg gatatttcct ggcctgcgaa     3120

aaagaacgtg acctcttcaa gctaatcctg aagaaggagg acgagctcgg tgacaggagc     3180

atcatgttta ctgtccaaaa cgaggactga tga                                  3213


<210>  225
<211>  2673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G12/2R-1 134 ECD

<400>  225

Ala Thr Gly Gly Cys Thr Cys Gly Cys Cys Thr Cys Gly Gly Ala Ala 
1               5                   10                  15      


Ala Thr Thr Gly Thr Thr Cys Cys Cys Thr Gly Ala Cys Cys Thr Gly 
            20                  25                  30          


Gly Gly Cys Ala Gly Cys Ala Thr Thr Gly Ala Thr Cys Ala Thr Thr 
        35                  40                  45              


Cys Thr Cys Cys Thr Gly Cys Thr Ala Cys Cys Ala Gly Gly Gly Ala 
    50                  55                  60                  


Gly Thr Cys Thr Cys Gly Ala Ala Gly Ala Ala Thr Gly Thr Gly Gly 
65                  70                  75                  80  


Cys Cys Ala Thr Ala Thr Cys Thr Cys Thr Gly Thr Ala Ala Gly Cys 
                85                  90                  95      


Gly Cys Cys Cys Cys Thr Ala Thr Thr Gly Thr Gly Cys Ala Cys Thr 
            100                 105                 110         


Thr Gly Gly Gly Ala Gly Ala Cys Cys Cys Ala Ala Thr Cys Ala Cys 
        115                 120                 125             


Ala Gly Cys Ala Thr Cys Ala Thr Gly Cys Ala Thr Cys Ala Thr Cys 
    130                 135                 140                 


Ala Ala Gly Cys Ala Gly Ala Ala Thr Thr Gly Cys Thr Cys Thr Cys 
145                 150                 155                 160 


Ala Thr Cys Thr Cys Gly Ala Thr Cys Cys Ala Gly Ala Gly Cys Cys 
                165                 170                 175     


Ala Cys Ala Gly Ala Thr Ala Cys Thr Cys Thr Gly Gly Gly Ala Gly 
            180                 185                 190         


Cys Thr Gly Gly Gly Cys Gly Cys Ala Gly Ala Ala Cys Thr Gly Cys 
        195                 200                 205             


Ala Ala Cys Cys Cys Gly Gly Ala Gly Gly Gly Cys Gly Cys Cys Ala 
    210                 215                 220                 


Gly Cys Ala Gly Ala Gly Ala Cys Thr Gly Ala Gly Thr Gly Ala Thr 
225                 230                 235                 240 


Gly Gly Ala Ala Cys Ala Cys Ala Gly Gly Ala Gly Ala Gly Cys Ala 
                245                 250                 255     


Thr Thr Ala Thr Cys Ala Cys Thr Thr Thr Ala Cys Cys Thr Cys Ala 
            260                 265                 270         


Thr Cys Thr Gly Ala Ala Cys Cys Ala Cys Ala Cys Cys Cys Ala Gly 
        275                 280                 285             


Gly Cys Cys Thr Thr Thr Cys Thr Thr Ala Gly Cys Thr Gly Cys Thr 
    290                 295                 300                 


Gly Thr Thr Thr Gly Ala Ala Cys Thr Gly Gly Gly Gly Cys Ala Ala 
305                 310                 315                 320 


Cys Ala Gly Thr Cys Thr Cys Cys Ala Gly Ala Thr Thr Cys Thr Gly 
                325                 330                 335     


Gly Ala Cys Cys Ala Gly Gly Thr Gly Gly Ala Gly Cys Thr Gly Ala 
            340                 345                 350         


Gly Gly Gly Cys Gly Gly Gly Thr Thr Ala Cys Cys Cys Gly Cys Cys 
        355                 360                 365             


Cys Gly Cys Cys Ala Thr Thr Cys Cys Ala Cys Ala Cys Ala Ala Thr 
    370                 375                 380                 


Thr Thr Gly Thr Cys Cys Thr Gly Thr Cys Thr Cys Ala Thr Gly Ala 
385                 390                 395                 400 


Ala Cys Cys Thr Gly Ala Cys Ala Ala Cys Ala Ala Gly Thr Ala Gly 
                405                 410                 415     


Cys Cys Thr Gly Ala Thr Ala Thr Gly Cys Cys Ala Gly Thr Gly Gly 
            420                 425                 430         


Gly Ala Gly Cys Cys Ala Gly Gly Gly Cys Cys Gly Gly Ala Gly Ala 
        435                 440                 445             


Cys Cys Cys Ala Thr Cys Thr Cys Cys Cys Ala Ala Cys Thr Ala Gly 
    450                 455                 460                 


Thr Thr Thr Cys Ala Cys Gly Cys Thr Cys Ala Ala Gly Ala Gly Cys 
465                 470                 475                 480 


Thr Thr Cys Ala Ala Gly Thr Cys Ala Gly Ala Gly Gly Gly Gly Ala 
                485                 490                 495     


Ala Cys Thr Gly Cys Cys Ala Gly Ala Cys Ala Cys Ala Ala Gly Gly 
            500                 505                 510         


Gly Gly Ala Cys Ala Gly Cys Ala Thr Thr Cys Thr Cys Gly Ala Cys 
        515                 520                 525             


Thr Gly Thr Gly Thr Gly Cys Cys Cys Ala Ala Gly Gly Ala Cys Gly 
    530                 535                 540                 


Gly Gly Cys Ala Gly Ala Gly Thr Cys Ala Cys Thr Gly Thr Thr Gly 
545                 550                 555                 560 


Cys Ala Thr Thr Cys Cys Ala Gly Ala Cys Ala Ala Gly Cys Ala Thr 
                565                 570                 575     


Cys Thr Gly Cys Thr Gly Cys Thr Gly Thr Ala Thr Cys Ala Gly Ala 
            580                 585                 590         


Ala Cys Ala Thr Gly Gly Gly Cys Ala Thr Thr Thr Gly Gly Gly Thr 
        595                 600                 605             


Thr Cys Ala Gly Gly Cys Cys Gly Ala Ala Ala Ala Thr Gly Cys Cys 
    610                 615                 620                 


Cys Thr Cys Gly Gly Thr Ala Cys Thr Thr Cys Cys Ala Thr Gly Ala 
625                 630                 635                 640 


Gly Thr Cys Cys Ala Cys Ala Gly Thr Thr Gly Thr Gly Thr Cys Thr 
                645                 650                 655     


Thr Gly Ala Cys Cys Cys Cys Ala Thr Gly Gly Ala Thr Gly Thr Gly 
            660                 665                 670         


Gly Thr Gly Ala Ala Gly Cys Thr Gly Gly Ala Ala Cys Cys Gly Cys 
        675                 680                 685             


Cys Ala Ala Thr Gly Cys Thr Gly Ala Gly Gly Ala Cys Cys Ala Thr 
    690                 695                 700                 


Gly Gly Ala Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr Gly Ala Gly 
705                 710                 715                 720 


Gly Cys Thr Gly Cys Thr Cys Cys Gly Cys Cys Ala Cys Ala Gly Gly 
                725                 730                 735     


Cys Ala Gly Gly Gly Thr Gly Thr Cys Thr Gly Cys Ala Gly Cys Thr 
            740                 745                 750         


Gly Thr Gly Cys Thr Gly Gly Gly Ala Gly Cys Cys Cys Thr Gly Gly 
        755                 760                 765             


Cys Ala Gly Cys Cys Thr Gly Gly Ala Thr Thr Gly Cys Ala Cys Ala 
    770                 775                 780                 


Thr Ala Ala Ala Cys Cys Ala Ala Ala Ala Ala Thr Gly Thr Gly Ala 
785                 790                 795                 800 


Gly Cys Thr Gly Ala Gly Gly Cys Ala Cys Ala Ala Gly Cys Cys Cys 
                805                 810                 815     


Cys Ala Gly Ala Gly Ala Gly Gly Thr Gly Ala Gly Gly Cys Gly Ala 
            820                 825                 830         


Gly Thr Thr Gly Gly Gly Cys Cys Cys Thr Gly Gly Thr Ala Gly Gly 
        835                 840                 845             


Gly Cys Cys Thr Cys Thr Thr Cys Cys Thr Cys Thr Ala Gly Ala Ala 
    850                 855                 860                 


Gly Cys Cys Cys Thr Gly Cys Ala Gly Thr Ala Thr Gly Ala Ala Thr 
865                 870                 875                 880 


Thr Gly Thr Gly Thr Gly Gly Ala Thr Thr Ala Cys Thr Thr Cys Cys 
                885                 890                 895     


Cys Gly Cys Ala Ala Cys Cys Gly Cys Cys Thr Ala Cys Ala Cys Thr 
            900                 905                 910         


Cys Thr Thr Cys Ala Gly Ala Thr Cys Ala Gly Gly Thr Gly Thr Ala 
        915                 920                 925             


Thr Cys Cys Gly Gly Thr Gly Gly Cys Cys Thr Cys Thr Gly Cys Cys 
    930                 935                 940                 


Cys Gly Gly Cys Cys Ala Cys Thr Gly Gly Ala Gly Cys Gly Ala Cys 
945                 950                 955                 960 


Thr Gly Gly Thr Cys Thr Cys Cys Gly Ala Gly Cys Cys Thr Cys Gly 
                965                 970                 975     


Ala Ala Thr Thr Gly Ala Gly Ala Ala Cys Ala Ala Cys Ala Gly Ala 
            980                 985                 990         


Ala Cys Gly Gly Gly Cys Thr Cys  Cys Thr Ala Cys Gly  Gly Thr Gly 
        995                 1000                 1005             


Cys Gly  Thr Cys Thr Gly Gly  Ala Thr Ala Cys Ala  Thr Gly Gly 
    1010                 1015                 1020             


Thr Gly  Gly Ala Gly Gly Cys  Ala Gly Cys Gly Ala  Cys Ala Gly 
    1025                 1030                 1035             


Thr Thr  Gly Gly Ala Cys Cys  Cys Gly Cys Gly Thr  Ala Cys Ala 
    1040                 1045                 1050             


Gly Thr  Gly Cys Ala Gly Cys  Thr Gly Thr Thr Cys  Thr Gly Gly 
    1055                 1060                 1065             


Ala Ala  Gly Cys Cys Cys Gly  Thr Ala Cys Cys Thr  Cys Thr Gly 
    1070                 1075                 1080             


Gly Ala  Ala Gly Ala Gly Gly  Ala Thr Ala Gly Thr  Gly Gly Thr 
    1085                 1090                 1095             


Cys Gly  Gly Ala Thr Thr Cys  Ala Gly Gly Gly Ala  Thr Ala Thr 
    1100                 1105                 1110             


Gly Thr  Gly Gly Thr Cys Thr  Cys Thr Thr Gly Gly  Cys Gly Gly 
    1115                 1120                 1125             


Cys Cys  Thr Thr Cys Cys Gly  Gly Thr Cys Ala Gly  Gly Cys Thr 
    1130                 1135                 1140             


Gly Gly  Gly Gly Cys Thr Ala  Thr Cys Cys Thr Thr  Cys Cys Cys 
    1145                 1150                 1155             


Thr Thr  Ala Thr Gly Cys Ala  Ala Cys Ala Cys Thr  Ala Cys Ala 
    1160                 1165                 1170             


Gly Ala  Gly Cys Thr Cys Ala  Gly Cys Thr Gly Thr  Ala Cys Cys 
    1175                 1180                 1185             


Thr Thr  Thr Cys Ala Thr Thr  Thr Ala Cys Cys Cys  Ala Gly Cys 
    1190                 1195                 1200             


Gly Ala  Ala Gly Cys Cys Cys  Ala Gly Gly Ala Ala  Gly Thr Gly 
    1205                 1210                 1215             


Gly Cys  Thr Cys Thr Cys Gly  Thr Cys Gly Cys Cys  Thr Ala Thr 
    1220                 1225                 1230             


Ala Ala  Thr Thr Cys Cys Gly  Cys Thr Gly Gly Ala  Ala Cys Gly 
    1235                 1240                 1245             


Thr Cys  Ala Ala Gly Ala Cys  Cys Cys Ala Cys Cys  Cys Cys Thr 
    1250                 1255                 1260             


Gly Thr  Cys Gly Thr Gly Thr  Thr Cys Thr Cys Thr  Gly Ala Gly 
    1265                 1270                 1275             


Thr Cys  Thr Cys Gly Gly Gly  Gly Ala Cys Cys Thr  Gly Cys Cys 
    1280                 1285                 1290             


Cys Thr  Ala Ala Cys Cys Ala  Gly Gly Cys Thr Cys  Cys Ala Thr 
    1295                 1300                 1305             


Gly Cys  Ala Ala Thr Gly Gly  Cys Ala Cys Gly Cys  Gly Ala Thr 
    1310                 1315                 1320             


Cys Cys  Thr Cys Ala Cys Ala  Gly Thr Cys Thr Gly  Thr Gly Gly 
    1325                 1330                 1335             


Gly Thr  Thr Gly Gly Cys Thr  Gly Gly Gly Ala Ala  Cys Cys Ala 
    1340                 1345                 1350             


Cys Cys  Ala Ala Ala Thr Cys  Cys Cys Thr Gly Gly  Cys Cys Thr 
    1355                 1360                 1365             


Cys Ala  Gly Gly Gly Cys Thr  Ala Thr Gly Thr Cys  Ala Thr Cys 
    1370                 1375                 1380             


Gly Ala  Ala Thr Gly Gly Gly  Gly Cys Cys Thr Thr  Gly Gly Cys 
    1385                 1390                 1395             


Cys Cys  Cys Cys Cys Ala Thr  Cys Ala Gly Cys Cys  Thr Cys Cys 
    1400                 1405                 1410             


Ala Ala  Thr Ala Gly Cys Ala  Ala Cys Ala Ala Gly  Ala Cys Cys 
    1415                 1420                 1425             


Thr Gly  Gly Ala Gly Ala Ala  Thr Gly Gly Ala Gly  Cys Ala Ala 
    1430                 1435                 1440             


Ala Ala  Thr Gly Gly Gly Ala  Gly Ala Gly Cys Ala  Ala Cys Cys 
    1445                 1450                 1455             


Gly Gly  Gly Thr Thr Cys Cys  Thr Gly Cys Thr Gly  Ala Ala Gly 
    1460                 1465                 1470             


Gly Ala  Gly Ala Ala Cys Ala  Thr Cys Cys Gly Ala  Cys Cys Gly 
    1475                 1480                 1485             


Thr Thr  Cys Cys Ala Gly Cys  Thr Thr Thr Ala Thr  Gly Ala Ala 
    1490                 1495                 1500             


Ala Thr  Thr Ala Thr Thr Gly  Thr Ala Ala Cys Thr  Cys Cys Ala 
    1505                 1510                 1515             


Cys Thr  Gly Thr Ala Cys Cys  Ala Gly Gly Ala Cys  Ala Cys Ala 
    1520                 1525                 1530             


Ala Thr  Gly Gly Gly Ala Cys  Cys Ala Thr Cys Thr  Cys Ala Gly 
    1535                 1540                 1545             


Cys Ala  Thr Gly Thr Cys Thr  Ala Cys Gly Cys Thr  Thr Ala Thr 
    1550                 1555                 1560             


Thr Cys  Cys Cys Ala Gly Gly  Ala Gly Ala Thr Gly  Gly Cys Gly 
    1565                 1570                 1575             


Cys Cys  Thr Ala Gly Thr Cys  Ala Thr Gly Cys Thr  Cys Cys Thr 
    1580                 1585                 1590             


Gly Ala  Ala Thr Thr Ala Cys  Ala Cys Thr Thr Gly  Ala Ala Gly 
    1595                 1600                 1605             


Cys Ala  Cys Ala Thr Ala Gly  Gly Gly Ala Ala Ala  Ala Cys Thr 
    1610                 1615                 1620             


Thr Gly  Gly Gly Cys Cys Cys  Ala Ala Thr Thr Ala  Gly Ala Gly 
    1625                 1630                 1635             


Thr Gly  Gly Gly Thr Cys Cys  Cys Gly Gly Ala Gly  Cys Cys Thr 
    1640                 1645                 1650             


Cys Cys  Cys Gly Ala Gly Cys  Thr Gly Gly Gly Gly  Ala Ala Ala 
    1655                 1660                 1665             


Ala Gly  Cys Cys Cys Ala Thr  Thr Gly Ala Cys Cys  Cys Ala Thr 
    1670                 1675                 1680             


Thr Ala  Cys Ala Cys Gly Ala  Thr Ala Thr Thr Thr  Thr Gly Gly 
    1685                 1690                 1695             


Ala Cys  Cys Ala Ala Thr Gly  Cys Thr Cys Ala Gly  Ala Ala Cys 
    1700                 1705                 1710             


Cys Ala  Ala Thr Cys Cys Thr  Thr Thr Thr Cys Thr  Gly Cys Cys 
    1715                 1720                 1725             


Ala Thr  Cys Cys Thr Gly Ala  Ala Thr Gly Cys Cys  Thr Cys Ala 
    1730                 1735                 1740             


Thr Cys  Thr Cys Gly Ala Gly  Gly Cys Thr Thr Thr  Gly Thr Gly 
    1745                 1750                 1755             


Cys Thr  Gly Cys Ala Thr Gly  Gly Cys Cys Thr Ala  Gly Ala Gly 
    1760                 1765                 1770             


Cys Cys  Thr Gly Cys Ala Thr  Cys Ala Cys Thr Cys  Thr Ala Cys 
    1775                 1780                 1785             


Cys Ala  Cys Ala Thr Thr Cys  Ala Cys Cys Thr Gly  Ala Thr Gly 
    1790                 1795                 1800             


Gly Cys  Cys Gly Cys Cys Ala  Gly Cys Cys Ala Gly  Gly Cys Gly 
    1805                 1810                 1815             


Gly Gly  Thr Gly Cys Cys Ala  Cys Ala Ala Ala Cys  Thr Cys Cys 
    1820                 1825                 1830             


Ala Cys  Ala Gly Thr Thr Cys  Thr Cys Ala Cys Thr  Thr Thr Ala 
    1835                 1840                 1845             


Ala Thr  Gly Ala Cys Thr Cys  Thr Ala Ala Cys Cys  Cys Cys Ala 
    1850                 1855                 1860             


Gly Ala  Gly Gly Gly Cys Ala  Gly Thr Gly Ala Ala  Cys Thr Gly 
    1865                 1870                 1875             


Cys Ala  Cys Ala Thr Cys Ala  Thr Ala Thr Thr Ala  Gly Gly Gly 
    1880                 1885                 1890             


Thr Thr  Ala Thr Thr Cys Gly  Gly Ala Thr Thr Gly  Cys Thr Gly 
    1895                 1900                 1905             


Cys Thr  Thr Cys Thr Thr Thr  Thr Gly Ala Cys Thr  Thr Gly Cys 
    1910                 1915                 1920             


Cys Thr  Cys Thr Gly Thr Gly  Gly Cys Ala Cys Thr  Gly Cys Gly 
    1925                 1930                 1935             


Thr Gly  Gly Cys Thr Gly Thr  Gly Cys Thr Gly Cys  Thr Cys Cys 
    1940                 1945                 1950             


Cys Cys  Gly Ala Ala Cys Cys  Gly Ala Ala Ala Gly  Ala Ala Thr 
    1955                 1960                 1965             


Cys Cys  Thr Cys Thr Cys Thr  Gly Gly Cys Cys Thr  Ala Gly Cys 
    1970                 1975                 1980             


Gly Thr  Thr Cys Cys Cys Gly  Ala Thr Cys Cys Thr  Gly Cys Thr 
    1985                 1990                 1995             


Cys Ala  Cys Ala Gly Thr Thr  Cys Ala Cys Thr Ala  Gly Gly Ala 
    2000                 2005                 2010             


Thr Cys  Ala Thr Gly Gly Gly  Thr Gly Cys Cys Ala  Ala Cys Cys 
    2015                 2020                 2025             


Ala Thr  Cys Ala Thr Gly Gly  Ala Ala Gly Ala Gly  Gly Ala Thr 
    2030                 2035                 2040             


Gly Cys  Cys Thr Thr Cys Cys  Ala Gly Cys Thr Ala  Cys Cys Ala 
    2045                 2050                 2055             


Gly Gly  Ala Cys Thr Gly Gly  Gly Thr Ala Cys Gly  Cys Cys Gly 
    2060                 2065                 2070             


Cys Cys  Cys Ala Thr Ala Ala  Cys Cys Ala Ala Ala  Thr Thr Ala 
    2075                 2080                 2085             


Ala Cys  Gly Gly Thr Cys Cys  Thr Thr Gly Ala Ala  Gly Ala Gly 
    2090                 2095                 2100             


Gly Ala  Thr Gly Ala Gly Ala  Ala Gly Ala Ala Ala  Cys Cys Ala 
    2105                 2110                 2115             


Gly Thr  Thr Cys Cys Ala Thr  Gly Gly Gly Ala Ala  Ala Gly Cys 
    2120                 2125                 2130             


Cys Ala  Cys Thr Cys Thr Thr  Cys Cys Ala Ala Thr  Cys Ala Thr 
    2135                 2140                 2145             


Ala Gly  Cys Cys Thr Cys Ala  Cys Cys Thr Cys Thr  Thr Gly Cys 
    2150                 2155                 2160             


Thr Thr  Cys Ala Cys Cys Ala  Ala Cys Cys Ala Ala  Gly Gly Gly 
    2165                 2170                 2175             


Thr Ala  Thr Thr Thr Thr Thr  Thr Thr Thr Thr Cys  Cys Ala Cys 
    2180                 2185                 2190             


Cys Thr  Gly Cys Cys Cys Gly  Ala Cys Gly Cys Thr  Cys Thr Gly 
    2195                 2200                 2205             


Gly Ala  Ala Ala Thr Thr Gly  Ala Gly Gly Cys Cys  Thr Gly Cys 
    2210                 2215                 2220             


Cys Ala  Ala Gly Thr Gly Thr  Ala Thr Thr Thr Cys  Ala Cys Cys 
    2225                 2230                 2235             


Thr Ala  Cys Gly Ala Cys Cys  Cys Thr Thr Ala Cys  Thr Cys Thr 
    2240                 2245                 2250             


Gly Ala  Ala Gly Ala Ala Gly  Ala Thr Cys Cys Gly  Gly Cys Ala 
    2255                 2260                 2265             


Gly Gly  Cys Gly Ala Cys Cys  Thr Ala Cys Cys Cys  Ala Cys Thr 
    2270                 2275                 2280             


Cys Ala  Thr Gly Ala Thr Gly  Gly Cys Thr Ala Cys  Cys Thr Gly 
    2285                 2290                 2295             


Cys Cys  Gly Thr Cys Ala Ala  Ala Cys Ala Thr Cys  Gly Ala Cys 
    2300                 2305                 2310             


Gly Ala  Cys Thr Thr Ala Cys  Cys Gly Ala Gly Thr  Gly Gly Ala 
    2315                 2320                 2325             


Gly Gly  Ala Cys Cys Cys Thr  Cys Cys Cys Cys Ala  Cys Cys Thr 
    2330                 2335                 2340             


Thr Cys  Thr Ala Cys Ala Gly  Cys Cys Cys Cys Thr  Gly Gly Thr 
    2345                 2350                 2355             


Gly Gly  Cys Thr Cys Cys Gly  Gly Thr Gly Cys Ala  Gly Gly Gly 
    2360                 2365                 2370             


Gly Ala  Gly Gly Ala Ala Ala  Gly Gly Ala Thr Gly  Cys Cys Thr 
    2375                 2380                 2385             


Cys Cys  Cys Thr Cys Ala Cys  Thr Gly Cys Ala Gly  Gly Ala Gly 
    2390                 2395                 2400             


Ala Gly  Ala Gly Thr Cys Cys  Cys Cys Ala Gly Ala  Gly Ala Cys 
    2405                 2410                 2415             


Thr Gly  Gly Gly Ala Thr Cys  Cys Thr Cys Ala Gly  Cys Cys Ala 
    2420                 2425                 2430             


Cys Thr  Thr Gly Gly Ala Cys  Cys Ala Cys Cys Cys  Ala Cys Ala 
    2435                 2440                 2445             


Cys Cys  Thr Gly Gly Thr Gly  Thr Gly Cys Cys Thr  Gly Ala Cys 
    2450                 2455                 2460             


Cys Thr  Thr Gly Thr Gly Gly  Ala Thr Thr Thr Thr  Cys Ala Gly 
    2465                 2470                 2475             


Cys Cys  Cys Cys Cys Thr Cys  Cys Thr Gly Ala Gly  Cys Thr Thr 
    2480                 2485                 2490             


Gly Thr  Thr Cys Thr Thr Cys  Gly Ala Gly Ala Ala  Gly Cys Ala 
    2495                 2500                 2505             


Gly Gly  Thr Gly Ala Gly Gly  Ala Gly Gly Thr Thr  Cys Cys Thr 
    2510                 2515                 2520             


Gly Ala  Thr Gly Cys Ala Gly  Gly Cys Cys Cys Ala  Cys Gly Thr 
    2525                 2530                 2535             


Gly Ala  Gly Gly Gly Gly Gly  Thr Cys Thr Cys Cys  Thr Thr Thr 
    2540                 2545                 2550             


Cys Cys  Cys Thr Gly Gly Thr  Cys Cys Ala Gly Gly  Cys Cys Thr 
    2555                 2560                 2565             


Cys Cys  Thr Gly Gly Cys Cys  Ala Ala Gly Gly Ala  Gly Ala Gly 
    2570                 2575                 2580             


Thr Thr  Cys Cys Gly Cys Gly  Cys Thr Cys Thr Gly  Ala Ala Thr 
    2585                 2590                 2595             


Gly Cys  Ala Cys Gly Cys Thr  Thr Gly Cys Cys Thr  Cys Thr Gly 
    2600                 2605                 2610             


Ala Ala  Cys Ala Cys Ala Gly  Ala Thr Gly Cys Thr  Thr Ala Cys 
    2615                 2620                 2625             


Cys Thr  Gly Ala Gly Cys Cys  Thr Ala Cys Ala Ala  Gly Ala Gly 
    2630                 2635                 2640             


Thr Thr  Ala Cys Ala Ala Gly  Gly Cys Cys Ala Gly  Gly Ala Thr 
    2645                 2650                 2655             


Cys Cys  Gly Ala Cys Ala Cys  Ala Cys Cys Thr Gly  Gly Thr Gly 
    2660                 2665                 2670             


<210>  226
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  226

Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Ala Gly Gly Gly Thr Ala 
1               5                   10                  15      


Gly Ala Gly Gly Cys Ala Gly Cys Cys Thr Cys Cys Thr Ala Ala Cys 
            20                  25                  30          


Thr Thr Gly Thr Gly Gly Cys Gly Ala Cys Gly Thr Gly Gly Ala Gly 
        35                  40                  45              


Gly Ala Gly Ala Ala Cys Cys Cys Cys Gly Gly Thr Cys Cys Cys 
    50                  55                  60              


<210>  227
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc epitope

<400>  227

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  228
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag epitope

<400>  228

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  229
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human G-CSF recombinantly produced in E. coli

<400>  229

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  230
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV-cleavable Twin Strep tag

<400>  230

Ala Ala Ala Glu Asn Leu Tyr Phe Gln Gly Ser Ala Trp Ser His Pro 
1               5                   10                  15      


Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala 
            20                  25                  30          


Trp Ser His Pro Gln Phe Glu Lys 
        35                  40  


<210>  231
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV-cleavable Hexahistidine

<400>  231

His His His His His His Ser Ser Gly Arg Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Gly Ser Met Gly 
            20  


