
                                SEQUENCE LISTING

<110> IMMUNOME, INC.

<120> IL-38-Specific Antibodies

<130> 22419-20003.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 63/236,454
<151> 2021-08-24

<150> US 63/167,105
<151> 2021-03-28

<160> 106

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 355
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone PR087-29B5 IL38 VH nucleic acid

<400> 1
gtgaaggtct cctgcaaggc ttctggttac agctttatca actatggcat cacctgggtg 60
cgccaggtcc ctggacaagg gcttgagtgg atgggatgga tcagcgctta caatgttaag 120
acaaagtatg caccgaagtt ccagggcaga gtcaacatga atacagacac atccacgagg 180
acagcctaca tggagctgag gagcctgaga tctgacgaca cggccgtcta ttactgtgcg 240
agagataggg attacgattt ttggagtggt tcggcttttg atatctgggg ccaagggaca 300
atggtcaccg tctcttcagc ctccaccaag ggcccatcgg tcttccccct ggcgc      355

<210> 2
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone PR087-29B5 IL38 VH amino acid

<400> 2
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr Gly
 1               5                  10                  15      
Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met Gly
            20                  25                  30          
Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys Tyr Ala Pro Lys Phe Gln
        35                  40                  45              
Gly Arg Val Asn Met Asn Thr Asp Thr Ser Thr Arg Thr Ala Tyr Met
    50                  55                  60                  
Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala
65                  70                  75                  80  
Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile Trp
                85                  90                  95      
Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
            100                 105                 110         
Ser Val Phe Pro Leu Ala
        115


<210> 3
<211> 308
<212> DNA
<213> Homo sapiens

<220> 
<223> Clone PR087-29B5 IL38 VL nucleic acid

<400> 3
aagagtcacc ctctcctgca gggccagtca gagtattagc accaactact tagcctggta 60
ccagcagaaa cctggccagg ctcccagtct actcatctat ggtgcatcca gcagggccac 120
tggcatccca gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag 180
cagactggag cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc 240
gaggactttt ggccagggga ccaagctgga gatcagacga actgtggctg caccatctgt 300
cttcatct                                                          308

<210> 4
<211> 102
<212> PRT
<213> Homo sapiens

<220> 
<223> Clone PR087-29B5 IL38 VL amino acid

<400> 4
Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn Tyr
 1               5                  10                  15      
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile
            20                  25                  30          
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly
        35                  40                  45              
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro
    50                  55                  60                  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro
65                  70                  75                  80  
Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg Arg Thr Val Ala
                85                  90                  95      
Ala Pro Ser Val Phe Ile
            100


<210> 5
<211> 369
<212> DNA
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VH nucleic acid

<400> 5
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg 60
tcctgcaagg ccagcggcta cagcttcatc aactacggca tcacctgggt ccgacaggtg 120
ccaggacaag gcttggaatg gatgggctgg atcagcgcct acaacgtcaa gaccaaatac 180
gcccctaagt tccagggccg cgtgaacatg aacaccgaca ccagcaccag aaccgcctac 240
atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagacaga 300
gactacgact tttggagcgg cagcgccttc gatatctggg gccagggaac aatggtcacc 360
gtgtctagt                                                         369

<210> 6
<211> 369
<212> DNA
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VH codon optimized expression fragment nucleic acid

<400> 6
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg 60
tcctgcaagg ccagcggcta cagcttcatc aactacggca tcacctgggt ccgacaggtg 120
ccaggacaag gcttggaatg gatgggctgg atcagcgcct acaacgtcaa gaccaaatac 180
gcccctaagt tccagggccg cgtgaacatg aacaccgaca ccagcaccag aaccgcctac 240
atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagacaga 300
gactacgact tttggagcgg cagcgccttc gatatctggg gccagggaac aatggtcacc 360
gtgtctagt                                                         369

<210> 7
<211> 123
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VH amino acid

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr
            20                  25                  30          
Gly Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys Tyr Ala Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Asn Met Asn Thr Asp Thr Ser Thr Arg Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120             


<210> 8
<211> 324
<212> DNA
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VL nucleic acid

<400> 8
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagtgacc 60
ctgagctgta gagccagcca gagcatcagc accaactacc tggcctggta tcagcagaag 120
cctggacagg ctcctagcct gctgatctac ggcgcctctt ctagagccac aggcatcccc 180
gatagattca gcggctctgg cagcggcacc gatttcaccc tgacaatcag cagactggaa 240
cccgaggact tcgccgtgta ctactgtcag cagtacggca gcagccctcc tagaacattt 300
ggccagggca ccaagctgga aatc                                        324

<210> 9
<211> 327
<212> DNA
<213> Homosapiens

<220> 
<223> IMM20130 IL38 VL codon optimized expression fragment nucleic acid

<400> 9
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagtgacc 60
ctgagctgta gagccagcca gagcatcagc accaactacc tggcctggta tcagcagaag 120
cctggacagg ctcctagcct gctgatctac ggcgcctctt ctagagccac aggcatcccc 180
gatagattca gcggctctgg cagcggcacc gatttcaccc tgacaatcag cagactggaa 240
cccgaggact tcgccgtgta ctactgtcag cagtacggca gcagccctcc tagaacattt 300
ggccagggca ccaagctgga aatcaag                                     327

<210> 10
<211> 109
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VL amino acid

<400> 10
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
                85                  90                  95      
Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 


<210> 11
<211> 1365
<212> DNA
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 HC nucleic acid

<400> 11
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg 60
tcctgcaagg ccagcggcta cagcttcatc aactacggca tcacctgggt ccgacaggtg 120
ccaggacaag gcttggaatg gatgggctgg atcagcgcct acaacgtcaa gaccaaatac 180
gcccctaagt tccagggccg cgtgaacatg aacaccgaca ccagcaccag aaccgcctac 240
atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagacaga 300
gactacgact tttggagcgg cagcgccttc gatatctggg gccagggaac aatggtcacc 360
gtgtctagtg ccagcaccaa gggcccttcc gtgtttccac tggccccctc ctctaaatcc 420
acatctggcg gcaccgccgc cctgggctgt ctggtgaagg actacttccc agagcctgtg 480
acagtgtcct ggaactctgg cgccctgaca tccggcgtgc acacatttcc agccgtgctg 540
cagagctccg gcctgtacag cctgtctagc gtggtgacag tgccctcctc tagcctgggc 600
acacagacct atatctgcaa cgtgaatcac aagccaagca ataccaaggt ggacaagaag 660
gtggagccca agtcctgtga taagacacac acctgccccc cttgtcctgc tcccgagctg 720
ctgggcggcc ctagcgtgtt cctgtttcca cccaagccta aggacaccct gatgatctcc 780
cggacacccg aggtgacctg cgtggtggtg gacgtgtctc acgaggatcc tgaggtgaag 840
ttcaactggt atgtggatgg cgtggaggtg cacaatgcca agaccaagcc cagagaggag 900
cagtacaact ctacatatag ggtggtgagc gtgctgaccg tgctgcacca ggactggctg 960
aacggcaagg agtataagtg caaggtgtcc aataaggccc tgcccgcccc catcgagaag 1020
acaatcagca aggccaaggg ccagcctcgg gagccacagg tgtacaccct gcctccatcc 1080
agagacgagc tgacaaagaa ccaggtgtct ctgacatgtc tggtgaaggg cttctatcct 1140
agcgatatcg ccgtggagtg ggagtccaat ggccagccag agaacaatta caagaccaca 1200
ccccctgtgc tggactccga tggctccttc tttctgtatt ccaagctgac cgtggataag 1260
tctcggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc cctgcataat 1320
cactatactc agaaatccct gtccctgtca cctggaaagt gataa                 1365

<210> 12
<211> 453
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 HC amino acid

<400> 12
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr
            20                  25                  30          
Gly Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys Tyr Ala Pro Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Asn Met Asn Thr Asp Thr Ser Thr Arg Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450


<210> 13
<211> 654
<212> DNA
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 LC nucleic acid

<400> 13
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagtgacc 60
ctgagctgta gagccagcca gagcatcagc accaactacc tggcctggta tcagcagaag 120
cctggacagg ctcctagcct gctgatctac ggcgcctctt ctagagccac aggcatcccc 180
gatagattca gcggctctgg cagcggcacc gatttcaccc tgacaatcag cagactggaa 240
cccgaggact tcgccgtgta ctactgtcag cagtacggca gcagccctcc tagaacattt 300
ggccagggca ccaagctgga aatcaagagg acagtggccg ccccaagcgt gttcatcttt 360
cccccttccg acgagcagct gaagtctggc accgccagcg tggtgtgcct gctgaacaac 420
ttctaccctc gggaggccaa ggtccagtgg aaggtggata acgccctgca gtctggcaat 480
agccaggagt ccgtgaccga gcaggactct aaggatagca catattccct gtctagcacc 540
ctgacactga gcaaggccga ttacgagaag cacaaggtgt atgcctgtga agtcacccat 600
caggggctgt catcacccgt cactaagtca ttcaatcgcg gagaatgctg ataa       654

<210> 14
<211> 216
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 LC amino acid

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
                85                  90                  95      
Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 15
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VH-CDR1 amino acid

<400> 15
Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr Gly Ile Thr
 1               5                  10              


<210> 16
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38VH-CDR2amino acid

<400> 16
Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys
 1               5                  10  


<210> 17
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38VH-CDR3amino acid

<400> 17
Ala Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile
 1               5                  10                  15      


<210> 18
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VL-CDR1 amino acid

<400> 18
Arg Ala Ser Gln Ser Ile Ser Thr Asn Tyr Leu Ala
 1               5                  10          


<210> 19
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VL-CDR2 amino acid

<400> 19
Tyr Gly Ala Ser Ser Arg Ala Thr
 1               5              


<210> 20
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> IMM20130 IL38 VL-CDR3 amino acid

<400> 20
Gln Gln Tyr Gly Ser Ser Pro Pro Arg Thr
 1               5                  10  


<210> 21
<211> 352
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH nucleic acid

<400> 21
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaaaata 60
ccctgcaagg cttctggata cacattcact gactacaata tggactgggt gaagcagagc 120
catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactatctac 180
aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcttccag cacagcctac 240
atggagctcc gcagcctgac atctgaggac actgcagtct attactgttc aagaccctat 300
tatggttact ttgcttactg gggccaaggg actctggtca ctgtctctgc ag         352

<210> 22
<211> 117
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH amino acid

<400> 22
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ala
        115


<210> 23
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH CDR1 amino acid

<400> 23
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp
 1               5                  10              


<210> 24
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH CDR2 amino acid

<400> 24
Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile
 1               5                  10  


<210> 25
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH CDR3 amino acid

<400> 25
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr
 1               5                  10  


<210> 26
<211> 337
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH Alternate nucleic acid

<400> 26
gaggtccagc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg 60
tcctgcaagg cttctggcta cacattcact gactactaca tacactgggt gaagcagagc 120
catggaaagg gccttgagtg gattggatat atttttccta ataatggtgg taatggctac 180
agccagaagt tcaagggcaa ggccacaatg actgtagaca agtcctccag cacagcctac 240
atggagctcc gcagcctgac atctgaggac tctgcagtct attattgtgc aagatttgtt 300
tactggggcc aagggacgct ggtcactgtc tctgcag                          337

<210> 27
<211> 112
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH Alternate amino acid

<400> 27
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly Tyr Ser Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
            100                 105                 110         


<210> 28
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH Alternate CDR1 amino acid

<400> 28
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His
 1               5                  10              


<210> 29
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH Alternate CDR2 amino acid

<400> 29
Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly
 1               5                  10  


<210> 30
<211> 11
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH Alternate CDR3 amino acid

<400> 30
Ala Arg Gly Gly Tyr Asp Ala Gly Phe Val Tyr
 1               5                  10      


<210> 31
<211> 355
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VH nucleic acid

<400> 31
gaggtccarc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg 60
tcctgcaagg cttctggcta cacattcact gactactaca tacactgggt gaagcagagc 120
catggaaagg gccttgagtg gattggatat atttttccta ataatggtgg taatggctac 180
agccagaagt tcaagggcaa ggccacaatg actgtagaca agtcctccag cacagcctac 240
atggagctcc gcagcctgac atctgaggac tctgcagtct attattgtgc aagagggggc 300
tacgacgcgg ggtttgttta ctggggccaa gggacgctgg tcactgtctc tgcag      355

<210> 32
<211> 118
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VH amino acid

<400> 32
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly Tyr Ser Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Tyr Asp Ala Gly Phe Val Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ala
        115


<210> 33
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VH CDR1 amino acid

<400> 33
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His
 1               5                  10              


<210> 34
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VH CDR2 amino acid

<400> 34
Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly
 1               5                  10  


<210> 35
<211> 11
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VH CDR3 amino acid

<400> 35
Ala Arg Gly Gly Tyr Asp Ala Gly Phe Val Tyr
 1               5                  10      


<210> 36
<211> 370
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C HC nucleic acid

<400> 36
gaggtgcagc ttgttgagtc tggtggaaga ttggtacagc ctaaagggtc attgaaactc 60
tcatgtgcag cctctggatt caccttcaat acctatgcca tgtactggat ccgccaggct 120
ccaggaaagg gtttggaatg ggttgctcgc ataagaacta aaagtaataa ttttgcaaca 180
tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaaacatg 240
ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgctc 300
ggatttggat ggcccactta ctatactctg gactactggg gtcaaggaac ctcagtcacc 360
gtctcctcag                                                        370

<210> 37
<211> 123
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VH amino acid

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Lys Gly
 1               5                  10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
            20                  25                  30          
Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Arg Thr Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala Asp
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Met
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95      
Tyr Cys Val Leu Gly Phe Gly Trp Pro Thr Tyr Tyr Thr Leu Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120             


<210> 38
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VH CDR1 amino acid

<400> 38
Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Tyr
 1               5                  10              


<210> 39
<211> 12
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VH CDR2 amino acid

<400> 39
Arg Ile Arg Thr Lys Ser Asn Asn Phe Ala Thr Tyr
 1               5                  10          


<210> 40
<211> 14
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VH CDR3 amino acid

<400> 40
Val Leu Gly Phe Gly Trp Pro Thr Tyr Tyr Thr Leu Asp Tyr
 1               5                  10                  


<210> 41
<211> 358
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VH nucleic acid

<400> 41
caggtccaac tgcagcagcc tggkgctgag cttgtgaagc ctggggcctc agtgaagctg 60
tcctgcaagg cttctggcta cactttcacc agctactgga taaactgggt gaagcagagg 120
cctggacaag gccttgagtg gattggaaat atttatcctg ttagtagtaa tactaagtac 180
aatgagaagt tcaagagtaa ggccacactg actgtagaca catcctccag cacagcctac 240
atgcagctca gcagcctgac atctgacgac tctgcggtct attattgtgc aagagggggg 300
tactacggtt atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcag   358

<210> 42
<211> 119
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VH amino acid

<400> 42
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asn Ile Tyr Pro Val Ser Ser Asn Thr Lys Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser
        115


<210> 43
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VH CDR1 amino acid

<400> 43
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn
 1               5                  10              


<210> 44
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VH CDR2 amino acid

<400> 44
Asn Ile Tyr Pro Val Ser Ser Asn Thr Lys
 1               5                  10  


<210> 45
<211> 12
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VH CDR3 amino acid

<400> 45
Ala Arg Gly Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr
 1               5                  10          


<210> 46
<211> 340
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VH nucleic acid

<400> 46
gaggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata 60
tcctgcaagg cttctggtta ctcattcact ggctactaca tgcactgggt gaagcaaagt 120
cctgaaaaga gccttgagtg gattggagtg attaatccta acactggtgg tattacctac 180
aaccagaagt tcaaggccaa ggccacattg aatgtagaca aatcctccag cacagcctac 240
atgcagctca agagcctgac atctgaggac tctgcagtct attactgtgc aagatcgatg 300
ggagtttggg gccaagggac tctggtcact gtctctgcag                       340

<210> 47
<211> 113
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VH amino acid

<400> 47
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Asn Pro Asn Thr Gly Gly Ile Thr Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Ala Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Met Gly Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ala
    


<210> 48
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VH CDR1 amino acid

<400> 48
Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His
 1               5                  10              


<210> 49
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VH CDR2 amino acid

<400> 49
Val Ile Asn Pro Asn Thr Gly Gly Ile Thr
 1               5                  10  


<210> 50
<211> 6
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VH CDR3 amino acid

<400> 50
Ala Arg Ser Met Gly Val
 1               5      


<210> 51
<211> 349
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VH nucleic acid

<400> 51
caggttcaac tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt 60
tcctgcaaag cttctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg 120
cctggaaagg gtcttgagtg gattggacgg atttatcctg gagatggaaa tactaagtac 180
aatgggatgt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac 240
atgcaactca gcagcctgac atctgaggac tctgcggtct tcttctgtgc aagaggggca 300
cgtggggagg actactgggg tcaaggaacc tcagtcaccg tctcctcag             349

<210> 52
<211> 116
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VH amino acid

<400> 52
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Arg Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Asn Gly Met Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys
                85                  90                  95      
Ala Arg Gly Ala Arg Gly Glu Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115


<210> 53
<211> 13
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VH CDR1 amino acid

<400> 53
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn
 1               5                  10              


<210> 54
<211> 10
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VH CDR2 amino acid

<400> 54
Arg Ile Tyr Pro Gly Asp Gly Asn Thr Lys
 1               5                  10  


<210> 55
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VH CDR3 amino acid

<400> 55
Ala Arg Gly Ala Arg Gly Glu Asp Tyr
 1               5                  


<210> 56
<211> 337
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VL nucleic acid

<400> 56
gatgttgtga tgacccaatc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60
atctctcgca gatttagtca gagccttgta cacagtcatg aaaacacctt tttacattgg 120
tacgtgcaga agccaggcca gtctccaaag ctcctgattt acagagtttc caaccgattt 180
tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240
agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg 300
ctcacgttcg gtgctgggac caagctggag ctgaaac                          337

<210> 57
<211> 112
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VL amino acid

<400> 57
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 58
<211> 16
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VL CDR1 amino acid

<400> 58
Arg Ser Ser Gln Ser Leu Val His Ser His Glu Asn Thr Phe Leu His
 1               5                  10                  15      


<210> 59
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VL CDR2 amino acid

<400> 59
Tyr Arg Val Ser Asn Arg Phe Ser
 1               5              


<210> 60
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VL CDR3 amino acid

<400> 60
Ser Gln Ser Thr His Val Pro Leu Thr
 1               5                  


<210> 61
<211> 337
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VL nucleic acid

<400> 61
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact 60
atgagctgca aatccagtca gagtctgttc aacagtggag cccgaaagaa cttcttggct 120
tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180
gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 240
atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttattatctg 300
atcacgttcg gtgctgggac caagctggag ctgaaac                          337

<210> 62
<211> 112
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VL amino acid

<400> 62
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser
            20                  25                  30          
Gly Ala Arg Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln
                85                  90                  95      
Ser Tyr Tyr Leu Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 63
<211> 17
<212> PRT
<213> Mus sp.

<220> 
<223> CloneM8 IL38-C VL CDR1 aminoacid

<400> 63
Lys Ser Ser Gln Ser Leu Phe Asn Ser Gly Ala Arg Lys Asn Phe Leu
 1               5                  10                  15      
Ala
    


<210> 64
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VL CDR2 amino acid

<400> 64
Tyr Trp Ala Ser Thr Arg Glu Ser
 1               5              


<210> 65
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-C VL CDR3 amino acid

<400> 65
Lys Gln Ser Tyr Tyr Leu Ile Thr
 1               5              


<210> 66
<211> 325
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VL nucleic acid

<400> 66
caaattgttc tcacccagtc tccagcaatc atgtctgcct ctccagggga aaaggtcacc 60
atgccctgca gtgccatgtc aagtgtcagt tccaggtact tgcactggaa ccagcagaag 120
tcaggagcct cccccaaact ctggatctat ggcgcatcca acctggcttc tggagtccct 180
gctcggttca gtggcagtgg gtctgggacc tcctactctc tcacaatcat cagcgtggag 240
gatgaagatg ctgccaccta ttactgccag cagtatcata gtggagcgct cacgttcgga 300
ggggggacca agctggagat gaaac                                       325

<210> 67
<211> 108
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VL amino acid

<400> 67
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Pro Cys Ser Ala Met Ser Ser Val Ser Ser Arg
            20                  25                  30          
Tyr Leu His Trp Asn Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ile Ser Val Glu
65                  70                  75                  80  
Asp Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Gly Ala
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys
            100                 105             


<210> 68
<211> 12
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VL CDR1 amino acid

<400> 68
Ser Ala Met Ser Ser Val Ser Ser Arg Tyr Leu His
 1               5                  10          


<210> 69
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VL CDR2 amino acid

<400> 69
Tyr Gly Ala Ser Asn Leu Ala Ser
 1               5              


<210> 70
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M27 IL38-C VL CDR3 amino acid

<400> 70
Gln Gln Tyr His Ser Gly Ala Leu Thr
 1               5                  


<210> 71
<211> 322
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VL nucleic acid

<400> 71
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc 60
ctcacatgtc gaccaagtgg gaatgttcac aattatttag catggtatca gcagaaacag 120
ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca 180
aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct 240
gaagattttg ggagttatta ctgtcaacat ttttggagta ctccattcac gttcggctcg 300
gggacaaagt tggaaataaa ac                                          322

<210> 72
<211> 107
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VL amino acid

<400> 72
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Glu Thr Val Thr Leu Thr Cys Arg Pro Ser Gly Asn Val His Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
        35                  40                  45              
Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 73
<211> 11
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VL CDR1 amino acid

<400> 73
Arg Pro Ser Gly Asn Val His Asn Tyr Leu Ala
 1               5                  10      


<210> 74
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VL CDR2 amino acid

<400> 74
Tyr Asn Ala Lys Thr Leu Ala Asp
 1               5              


<210> 75
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VL CDR3 amino acid

<400> 75
Gln His Phe Trp Ser Thr Pro Phe Thr
 1               5                  


<210> 76
<211> 337
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VL nucleic acid

<400> 76
gatattgtga tgactcaggc tgcaccctct gtatctgtca ctcctggaga gtcagtatcc 60
atctcctcca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg 120
ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc 180
tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc 240
agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaatatct agaatatcct 300
ttcacgttcg gctcggggac aaagctggaa ataaaac                          337

<210> 77
<211> 112
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VL amino acid

<400> 77
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Ser Val Thr Pro Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr
                85                  90                  95      
Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 78
<211> 16
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VL CDR1 amino acid

<400> 78
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
 1               5                  10                  15      


<210> 79
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VL CDR2 amino acid

<400> 79
Tyr Arg Met Ser Asn Leu Ala Ser
 1               5              


<210> 80
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M8 IL38-N VL CDR3 amino acid

<400> 80
Met Gln Tyr Leu Glu Tyr Pro Phe Thr
 1               5                  


<210> 81
<211> 325
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VL nucleic acid

<400> 81
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctccagggga aaaggtcacc 60
atgacctgca gggccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag 120
tcaggtgcct cccccaaact ctggatttat agcacatcca acttggcttc tggagtccct 180
gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagtgtggag 240
gctgaagatg ctgccactta ttactgccag cagtacggtg attttccact cacgttcgga 300
ggggggacca agctggaaat aaaac                                       325

<210> 82
<211> 108
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VL amino acid

<400> 82
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser
            20                  25                  30          
Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asp Phe Pro
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 83
<211> 12
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VL CDR1 amino acid

<400> 83
Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His
 1               5                  10          


<210> 84
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VL CDR2 amino acid

<400> 84
Tyr Ser Thr Ser Asn Leu Ala Ser
 1               5              


<210> 85
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M12 IL38-N VL CDR3 amino acid

<400> 85
Gln Gln Tyr Gly Asp Phe Pro Leu Thr
 1               5                  


<210> 86
<211> 343
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VH Nucleic acid

<400> 86
caggtccagc tgcagcagcc tggggctgag atggtgaggg ctggggcttc agtgaagttg 60
tcctgcaagg cttctggcta caccttcacc aactactgga tgcactgggt aaagcagagg 120
cctggacaag gccttgagtg gattggtaag attgatcctt ctgatagtga aactcactac 180
aatcaaaagt tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac 240
atgcagctca acagcctgac atctgaagac tctgcggtct attattgtca actctatctt 300
atggactact ggggtcaagg aacctcagtc accgtctcct cag                   343

<210> 87
<211> 114
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL-38C VH amino acid

<400> 87
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Met Val Arg Ala Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Lys Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Gln Leu Tyr Leu Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val
            100                 105                 110         
Ser Ser
        


<210> 88
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VH CDR1 amino acid

<400> 88
Gly Tyr Thr Phe Thr Asn Tyr Trp
 1               5              


<210> 89
<211> 8
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VH CDR2 amino acid

<400> 89
Ile Asp Pro Ser Asp Ser Glu Thr
 1               5              


<210> 90
<211> 7
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VH CDR3 amino acid

<400> 90
Gln Leu Tyr Leu Met Asp Tyr
 1               5          


<210> 91
<211> 336
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VL nucleic acid

<400> 91
gacgttgtgt tgacacagtc tcttctctcc ttagctgtat ctctggggga gagggcttcc 60
atcttttgca gatttagtca gagcctttca aacagcaatg gaaagtccta tttatattgg 120
ttcctgcaga agccaggcca gtctccaaag ctcctgatct acagggtttc caaccgattt 180
tctggggtcc cagccaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc 240
agcagagtgg aggctgagga tctgggagtt tatttctgct ttcaaggtgc acatgttcct 300
catacgttcg gatcggggac caagctggaa ataaaa                           336

<210> 92
<211> 112
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VL amino acid

<400> 92
Asp Val Val Leu Thr Gln Ser Leu Leu Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Asn Arg Gly Ala Lys Ser Ser Ile Tyr Phe Leu Cys Tyr Arg Trp
            20                  25                  30          
Phe Phe Ser Leu Gln Gln Ser Lys Leu Pro Ser Gly Asn Gln Ser Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly
                85                  90                  95      
Ala His Val Pro His Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 93
<211> 11
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VL CDR1 amino acid

<400> 93
Gln Ser Leu Ser Asn Ser Asn Gly Lys Ser Tyr
 1               5                  10      


<210> 94
<211> 3
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VL CDR2 amino acid

<400> 94
Arg Val Ser
1


<210> 95
<211> 9
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M26 IL38-C VL CDR3 amino acid

<400> 95
Phe Gln Gly Ala His Val Pro His Thr
 1               5                  


<210> 96
<211> 117
<212> PRT
<213> Homo sapiens

<400> 96
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Pro His Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115


<210> 97
<211> 117
<212> PRT
<213> Homo sapiens

<400> 97
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115


<210> 98
<211> 117
<212> PRT
<213> Homo sapiens

<400> 98
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115


<210> 99
<211> 117
<212> PRT
<213> Homo sapiens

<400> 99
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115


<210> 100
<211> 117
<212> PRT
<213> Homo sapiens

<400> 100
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asn Trp Val Lys Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110         
Val Thr Val Ser Ser
        115


<210> 101
<211> 112
<212> PRT
<213> Homo sapiens

<400> 101
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 102
<211> 112
<212> PRT
<213> Homo sapiens

<400> 102
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 103
<211> 112
<212> PRT
<213> Homo sapiens

<400> 103
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 104
<211> 112
<212> PRT
<213> Homo sapiens

<400> 104
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 105
<211> 112
<212> PRT
<213> Homo sapiens

<400> 105
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 106
<211> 112
<212> PRT
<213> Homo sapiens

<400> 106
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
His Glu Asn Thr Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
