                       SEQUENCE LISTING

<110> CODEXIS, INC.
 
<120> ENGINEERED ADENYLATE KINASE VARIANT ENZYMES
 
<130> CX2-201WO1

<140> 
<141> 

<150> US 63/170,000
<151> 2021-04-02

 
<160> 848
 
<210> 1
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> His-tagged variant of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 1
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aacgctttca tgctgctcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggcctg gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagcca ttgaactgaa agtggatgat gaactgctgg ttgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggcagc gtatcatgcc cagaccgaac cgattgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 2
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> His-tagged variant of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 2
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Ala His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Ile Glu Leu Lys Val 
        115                 120                 125             
Asp Asp Glu Leu Leu Val Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Ala Gln Thr 
            180                 185                 190         
Glu Pro Ile Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 3
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 3
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 4
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 4
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 5
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 5
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 6
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 6
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 7
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 7
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 8
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 8
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 9
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 9
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 10
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 10
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 11
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 11
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 12
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 12
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 13
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 13
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 14
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 14
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 15
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 15
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 16
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 16
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 17
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 17
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 18
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 18
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 19
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 19
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 20
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 20
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 21
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 21
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 22
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 22
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 23
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 23
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 24
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 24
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 25
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 25
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 26
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 26
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 27
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 27
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 28
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 28
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 29
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 29
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 30
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 30
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 31
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 31
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat acgctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 32
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 32
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Thr Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 33
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 33
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 34
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 34
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 35
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 35
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 36
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 36
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 37
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 37
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catcgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 38
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 38
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 39
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 39
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 40
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 40
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 41
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 41
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 42
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 42
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 43
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 43
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 44
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 44
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 45
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 45
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 46
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 46
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 47
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 47
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 48
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 48
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 49
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 49
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 50
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 50
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 51
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 51
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 52
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 52
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 53
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 53
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 54
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 54
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 55
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 55
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 56
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 56
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 57
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 57
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 58
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 58
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 59
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 59
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 60
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 60
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 61
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 61
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catcgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 62
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 62
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 63
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 63
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 64
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 64
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 65
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 65
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 66
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 66
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 67
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 67
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 68
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 68
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 69
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 69
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 70
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 70
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 71
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 71
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 72
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 72
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 73
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 73
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 74
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 74
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 75
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 75
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 76
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 76
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 77
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 77
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 78
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 78
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 79
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 79
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 80
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 80
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 81
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 81
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 82
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 82
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 83
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 83
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 84
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 84
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 85
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 85
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 86
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 86
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 87
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 87
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 88
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 88
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 89
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 89
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 90
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 90
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 91
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 91
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 92
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 92
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 93
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 93
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 94
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 94
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 95
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 95
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catcgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 96
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 96
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 97
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 97
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atggctaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 98
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 98
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Met Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 99
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 99
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 100
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 100
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 101
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 101
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 102
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 102
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 103
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 103
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 104
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 104
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 105
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 105
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 106
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 106
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 107
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 107
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcggtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 108
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 108
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 109
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 109
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 110
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 110
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 111
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 111
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 112
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 112
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 113
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 113
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 114
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 114
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 115
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 115
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 116
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 116
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 117
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 117
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat acgctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 118
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 118
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Thr Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 119
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 119
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 120
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 120
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 121
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 121
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 122
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 122
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 123
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 123
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 124
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 124
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 125
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 125
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 126
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 126
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 127
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 127
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 128
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 128
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 129
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 129
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 130
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 130
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 131
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 131
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 132
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 132
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 133
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 133
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 134
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 134
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 135
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 135
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 136
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 136
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 137
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 137
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 138
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 138
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 139
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 139
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 140
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 140
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 141
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 141
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 142
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 142
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 143
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 143
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 144
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 144
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 145
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 145
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 146
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 146
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 147
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 147
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 148
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 148
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 149
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 149
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcggtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 150
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 150
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 151
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 151
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 152
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 152
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 153
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 153
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 154
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 154
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 155
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 155
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcggtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 156
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 156
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 157
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 157
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 158
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 158
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 159
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 159
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 160
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 160
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 161
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 161
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 162
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 162
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 163
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 163
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 164
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 164
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 165
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 165
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 166
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 166
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 167
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 167
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggctattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 168
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 168
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 169
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 169
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 170
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 170
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 171
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 171
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 172
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 172
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 173
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 173
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 174
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 174
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 175
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 175
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 176
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 176
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 177
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 177
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggtcgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 178
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 178
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Val Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 179
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 179
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 180
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 180
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 181
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 181
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atggctaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 182
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 182
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Met Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 183
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 183
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 184
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 184
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 185
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 185
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tggcgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 186
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 186
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 187
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 187
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atggctaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 188
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 188
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Met Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 189
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 189
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 190
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 190
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 191
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 191
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 192
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 192
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 193
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 193
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag ctggctaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat acgctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 194
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 194
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Leu Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Thr Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 195
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 195
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 196
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 196
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 197
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 197
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gaactgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 198
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 198
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 199
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 199
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atggctattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 200
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 200
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Met Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 201
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 201
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 202
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 202
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 203
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 203
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catcgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 204
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 204
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 205
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 205
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 206
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 206
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 207
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 207
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 208
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 208
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 209
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 209
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 210
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 210
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 211
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 211
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 212
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 212
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 213
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 213
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcggtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 214
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 214
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 215
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 215
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 216
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 216
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 217
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 217
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcggtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 218
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 218
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 219
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 219
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagc tgaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tctgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 220
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 220
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Leu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Leu Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 221
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 221
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agcgctttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 222
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 222
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 223
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 223
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaggtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atcgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat tacgggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcgtcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaacgcggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 224
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 224
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Arg Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Arg Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 225
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 225
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaagtttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atccgtattg gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 226
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 226
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Lys Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Arg Ile Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 227
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 227
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg agaactttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag atggctaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 228
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 228
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Asn Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Met Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 229
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 229
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 230
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 230
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 231
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 231
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtg gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 232
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 232
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Trp Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 233
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 233
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga atttctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 234
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 234
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Phe Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 235
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 235
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
cagaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 236
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 236
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Gln Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 237
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 237
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
aataaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 238
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 238
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Asn Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 239
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 239
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 240
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 240
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 241
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 241
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 242
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 242
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 243
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 243
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgcggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 244
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 244
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Arg Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 245
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 245
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 246
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 246
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 247
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 247
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag ggggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 248
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 248
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Gly Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 249
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 249
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tgggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 250
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 250
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Trp Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 251
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 251
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag actgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 252
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 252
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Thr Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 253
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 253
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 254
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 254
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 255
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 255
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcgct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 256
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 256
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 257
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 257
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 258
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 258
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Leu Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 259
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 259
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
gtggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 260
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 260
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Val Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 261
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 261
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag tctgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 262
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 262
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 263
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 263
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgcggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 264
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 264
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Ala Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 265
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 265
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag gcggcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 266
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 266
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ala Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 267
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 267
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tagtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 268
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 268
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Ser Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 269
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 269
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatc cgattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 270
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 270
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Pro Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 271
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 271
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 272
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 272
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 273
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 273
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aagtctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 274
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 274
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 275
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 275
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga acagctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 276
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 276
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Gln Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 277
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 277
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatgacgct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 278
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 278
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Thr 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 279
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 279
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gttaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 280
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 280
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Val Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 281
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 281
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttgtggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 282
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 282
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Val Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 283
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 283
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 284
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 284
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 285
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 285
catatgcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt atcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 286
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 286
His Met His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 287
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 287
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
actgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 288
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 288
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Thr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 289
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 289
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga agagctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 290
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 290
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 291
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 291
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 292
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 292
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 293
<211> 687
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 293
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat catgttattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agattaa                                     687

 
<210> 294
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 294
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Val Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 295
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 295
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 296
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 296
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 297
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 297
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tgaggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 298
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 298
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Glu Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 299
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 299
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgtcgaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 300
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 300
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 301
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 301
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtggcggatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 302
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 302
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ala Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 303
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 303
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcgtgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 304
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 304
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Val Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 305
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 305
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatttgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 306
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 306
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Leu Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 307
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 307
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
acggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 308
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 308
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Thr Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 309
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 309
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtt taatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 310
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 310
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Phe Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 311
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 311
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgataagct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 312
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 312
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Lys Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 313
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 313
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatcggct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 314
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 314
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Arg Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 315
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 315
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 316
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 316
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 317
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 317
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatc atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 318
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 318
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp His Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 319
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 319
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ttgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 320
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 320
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 321
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 321
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg ttgccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 322
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 322
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 323
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 323
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaattggatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 324
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 324
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Trp Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 325
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 325
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
tatgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 326
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 326
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 327
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 327
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatcagct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 328
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 328
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Gln Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 329
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 329
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attaggaata aactgggtaa agat                                        684

 
<210> 330
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 330
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Arg Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 331
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 331
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgattatct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 332
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 332
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Tyr Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 333
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 333
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactggc gattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 334
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 334
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Ala Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 335
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 335
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga acgtctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 336
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 336
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Arg Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 337
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 337
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
catgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 338
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 338
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
His Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 339
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 339
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attagtaata aactgggtaa agat                                        684

 
<210> 340
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 340
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Ser Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 341
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 341
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
tgtgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 342
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 342
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Cys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 343
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 343
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagttgt attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 344
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 344
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Cys Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 345
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 345
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga agtgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 346
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 346
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Val Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 347
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 347
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtggaggatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 348
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 348
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Glu Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 349
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 349
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagata atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 350
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 350
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asn Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 351
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 351
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagata ttattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 352
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 352
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Ile Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 353
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 353
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactgcgg cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 354
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 354
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Arg Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 355
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 355
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggctaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtg taatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 356
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 356
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Cys Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 357
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 357
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 358
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 358
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 359
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 359
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 360
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 360
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 361
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 361
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 362
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 362
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 363
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 363
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 364
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 364
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 365
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 365
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 366
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 366
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 367
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 367
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 368
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 368
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 369
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 369
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 370
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 370
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 371
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 371
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 372
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 372
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 373
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 373
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 374
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 374
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 375
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 375
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 376
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 376
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 377
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 377
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 378
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 378
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 379
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 379
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 380
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 380
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 381
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 381
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 382
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 382
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 383
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 383
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 384
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 384
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 385
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 385
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 386
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 386
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 387
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 387
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cgtccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 388
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 388
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ser Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 389
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 389
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 390
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 390
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 391
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 391
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 392
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 392
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 393
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 393
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 394
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 394
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 395
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 395
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 396
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 396
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 397
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 397
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 398
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 398
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 399
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 399
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 400
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 400
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 401
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 401
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 402
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 402
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 403
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 403
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 404
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 404
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 405
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 405
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 406
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 406
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 407
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 407
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 408
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 408
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 409
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 409
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 410
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 410
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 411
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 411
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 412
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 412
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 413
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 413
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 414
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 414
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 415
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 415
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 416
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 416
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 417
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 417
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 418
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 418
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 419
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 419
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 420
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 420
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 421
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 421
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtgtg gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 422
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 422
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Trp Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 423
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 423
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 424
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 424
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 425
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 425
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 426
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 426
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 427
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 427
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 428
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 428
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 429
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 429
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 430
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 430
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 431
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 431
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 432
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 432
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 433
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 433
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 434
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 434
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 435
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 435
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 436
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 436
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 437
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 437
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 438
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 438
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 439
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 439
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 440
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 440
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 441
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 441
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 442
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 442
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 443
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 443
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 444
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 444
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 445
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 445
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 446
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 446
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 447
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 447
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 448
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 448
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 449
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 449
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 450
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 450
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 451
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 451
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 452
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 452
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 453
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 453
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 454
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 454
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 455
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 455
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 456
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 456
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 457
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 457
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 458
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 458
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 459
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 459
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 460
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 460
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 461
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 461
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 462
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 462
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 463
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 463
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 464
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 464
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 465
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 465
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 466
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 466
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 467
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 467
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 468
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 468
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 469
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 469
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 470
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 470
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 471
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 471
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 472
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 472
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 473
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 473
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 474
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 474
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 475
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 475
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 476
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 476
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 477
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 477
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 478
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 478
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 479
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 479
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 480
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 480
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 481
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 481
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 482
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 482
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 483
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 483
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 484
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 484
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 485
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 485
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
acggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 486
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 486
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Thr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 487
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 487
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 488
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 488
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 489
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 489
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 490
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 490
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 491
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 491
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 492
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 492
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 493
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 493
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 494
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 494
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 495
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 495
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 496
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 496
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 497
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 497
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 498
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 498
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 499
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 499
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 500
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 500
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 501
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 501
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 502
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 502
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 503
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 503
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 504
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 504
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 505
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 505
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 506
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 506
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 507
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 507
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 508
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 508
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 509
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 509
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 510
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 510
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 511
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 511
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 512
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 512
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 513
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 513
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 514
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 514
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 515
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 515
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 516
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 516
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 517
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 517
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 518
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 518
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 519
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 519
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 520
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 520
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 521
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 521
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 522
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 522
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 523
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 523
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 524
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 524
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 525
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 525
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 526
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 526
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 527
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 527
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 528
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 528
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 529
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 529
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 530
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 530
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 531
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 531
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 532
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 532
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 533
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 533
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 534
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 534
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 535
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 535
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 536
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 536
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 537
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 537
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 538
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 538
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 539
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 539
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 540
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 540
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 541
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 541
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 542
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 542
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 543
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 543
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 544
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 544
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 545
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 545
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 546
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 546
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 547
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 547
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 548
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 548
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 549
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 549
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 550
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 550
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 551
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 551
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 552
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 552
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 553
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 553
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 554
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 554
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 555
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 555
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 556
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 556
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 557
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 557
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 558
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 558
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 559
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 559
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 560
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 560
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 561
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 561
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 562
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 562
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 563
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 563
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgta 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 564
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 564
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Val Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 565
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 565
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 566
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 566
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 567
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 567
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 568
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 568
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 569
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 569
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
acggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 570
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 570
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Thr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 571
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 571
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 572
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 572
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 573
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 573
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 574
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 574
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 575
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 575
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 576
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 576
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 577
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 577
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 578
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 578
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 579
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 579
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 580
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 580
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 581
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 581
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 582
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 582
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 583
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 583
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 584
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 584
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 585
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 585
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 586
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 586
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 587
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 587
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 588
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 588
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 589
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 589
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 590
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 590
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 591
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 591
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 592
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 592
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 593
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 593
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 594
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 594
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 595
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 595
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
acggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 596
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 596
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Thr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 597
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 597
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 598
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 598
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 599
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 599
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 600
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 600
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 601
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 601
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 602
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 602
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 603
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 603
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 604
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 604
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 605
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 605
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 606
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 606
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 607
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 607
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 608
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 608
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 609
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 609
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 610
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 610
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 611
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 611
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 612
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 612
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 613
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 613
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 614
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 614
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 615
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 615
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 616
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 616
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 617
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 617
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 618
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 618
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 619
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 619
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 620
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 620
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 621
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 621
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 622
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 622
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 623
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 623
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 624
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 624
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 625
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 625
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 626
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 626
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 627
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 627
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 628
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 628
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 629
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 629
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 630
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 630
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 631
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 631
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 632
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 632
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 633
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 633
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaggccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 634
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 634
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 635
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 635
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 636
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 636
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 637
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 637
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 638
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 638
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 639
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 639
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 640
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 640
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 641
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 641
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 642
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 642
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 643
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 643
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 644
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 644
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 645
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 645
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 646
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 646
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 647
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 647
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 648
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 648
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 649
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 649
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 650
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 650
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 651
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 651
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 652
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 652
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 653
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 653
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 654
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 654
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 655
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 655
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 656
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 656
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 657
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 657
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 658
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 658
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 659
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 659
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 660
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 660
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 661
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 661
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 662
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 662
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 663
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 663
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 664
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 664
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 665
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 665
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 666
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 666
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 667
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 667
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 668
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 668
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 669
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 669
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 670
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 670
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 671
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 671
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 672
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 672
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 673
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 673
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 674
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 674
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 675
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 675
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 676
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 676
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 677
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 677
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 678
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 678
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 679
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 679
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 680
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 680
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 681
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 681
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 682
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 682
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 683
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 683
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
acggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 684
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 684
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Thr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 685
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 685
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatgtg gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 686
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 686
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Trp Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 687
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 687
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 688
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 688
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 689
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 689
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agatctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 690
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 690
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Asp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 691
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 691
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtggt taatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 692
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 692
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Val Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 693
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 693
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 694
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 694
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 695
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 695
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcgcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atggctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt tcgtgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 696
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 696
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ala Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Trp Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 697
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 697
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattgtgtg gaatatgatt 240
tacgatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 698
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 698
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Val Trp Asn Met Ile 
65                  70                  75                  80  
Tyr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 699
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 699
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcatgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt taatatgatt 240
acggatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 700
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 700
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Met Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Thr Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 701
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 701
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 702
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 702
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 703
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 703
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggcaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc ctcaggcgga atcgctggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatggt agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 704
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 704
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Ser Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Gly Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 705
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 705
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgagcaccg gcgatatgct gcgctcgcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattt accaggcgga agaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tacaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgct agtcagccgc cggccaccgt tcatgccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 706
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 706
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Ser Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Tyr Gln Ala Glu Glu Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val His Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 707
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 707
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 708
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 708
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 709
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 709
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 710
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 710
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 711
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 711
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 712
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 712
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 713
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 713
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 714
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 714
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 715
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 715
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 716
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 716
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 717
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 717
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 718
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 718
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 719
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 719
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 720
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 720
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 721
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 721
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 722
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 722
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 723
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 723
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 724
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 724
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 725
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 725
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagata tcattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 726
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 726
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Ile Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 727
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 727
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 728
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 728
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 729
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 729
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 730
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 730
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 731
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 731
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 732
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 732
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 733
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 733
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagata tcattatggt gaatctgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 734
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 734
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Ile Ile Met Val Asn Leu Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 735
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 735
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 736
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 736
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 737
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 737
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 738
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 738
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 739
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 739
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 740
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 740
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 741
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 741
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 742
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 742
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 743
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 743
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 744
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 744
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 745
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 745
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 746
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 746
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 747
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 747
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 748
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 748
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 749
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 749
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 750
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 750
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 751
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 751
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggt cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 752
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 752
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Val Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 753
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 753
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 754
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 754
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 755
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 755
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 756
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 756
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 757
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 757
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 758
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 758
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 759
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 759
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 760
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 760
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 761
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 761
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 762
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 762
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 763
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 763
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 764
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 764
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 765
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 765
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 766
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 766
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 767
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 767
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 768
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 768
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 769
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 769
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctgggtaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 770
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 770
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 771
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 771
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatc ctattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 772
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 772
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Pro Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 773
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 773
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 774
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 774
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 775
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 775
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 776
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 776
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 777
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 777
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 778
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 778
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 779
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 779
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 780
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 780
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 781
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 781
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 782
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 782
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 783
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 783
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 784
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 784
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 785
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 785
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 786
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 786
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 787
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 787
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt tcgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 788
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 788
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Arg Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 789
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 789
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 790
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 790
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 791
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 791
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 792
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 792
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 793
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 793
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 794
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 794
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 795
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 795
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 796
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 796
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 797
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 797
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 798
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 798
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 799
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 799
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgattacct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatctgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 800
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 800
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Tyr Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Leu Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 801
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 801
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgataagct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 802
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 802
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Lys Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 803
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 803
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 804
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 804
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 805
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 805
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 806
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 806
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 807
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 807
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 808
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 808
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 809
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 809
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 810
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 810
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 811
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 811
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagata tcattatggt gaatctgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 812
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 812
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Ile Ile Met Val Asn Leu Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 813
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 813
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 814
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 814
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 815
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 815
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 816
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 816
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 817
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 817
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 818
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 818
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 819
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 819
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 820
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 820
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 821
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 821
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggat cagatgctga aagaacaggg tacctgcctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 822
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 822
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Cys Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 823
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 823
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 824
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 824
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 825
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 825
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 826
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 826
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 827
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 827
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 828
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 828
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 829
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 829
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 830
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 830
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 831
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 831
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaactggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 832
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 832
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 833
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 833
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 834
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 834
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 835
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 835
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 836
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 836
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 837
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 837
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 838
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 838
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 839
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 839
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggcact gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag agtgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 840
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 840
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Ala 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ser Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 841
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 841
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggtact gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgattacct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg acattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag cagaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgg tagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 842
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 842
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Tyr Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 843
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 843
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccagtcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgattacct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccactg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 844
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 844
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Tyr Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 845
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 845
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag attgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgat gaaactggag cagatgctga aagaacaggg taccccgctg 360
gaaaaagtcg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag tataccgaac cggttgtgga tttttataaa 600
aaagctggta tttgggcggg cgttgatgcg agtcagccgc cagccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 846
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 846
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Val Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Tyr Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

 
<210> 847
<211> 684
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 847
atgcatcatc atcatcatca tagcagcagc gaaagtattc gtatggttct gattggtccg 60
ccgggtgcgg gcaaaggcac ccaggcgccg aatctgcagg aaagatttca tgcttgtcat 120
ctggggaccg gcgatatgct gcgcagtcag catgcaaaag gtacccagct gggtctggaa 180
gccaaaaaaa ttatggatca gggcggctta gtgtcagatg atattatggt gaatatgatt 240
aaagatgaac tgaccaataa tccggcttgc aaaaatggct ttattctgga tggctttccg 300
cgcaccattc cgcaggcgga aaaactggat cagatgctga aagaacaggg taccccgctg 360
gaaaaagccg ttgaactgaa aattgatgat gagctgctgc ctgcacgcat taccggtcgc 420
ctgattcatc cggcttcagg ccgttcttat cataaaattt ttaatccgcc gaaagaagat 480
atgaaagatg atgtgaccgg tgaagcactg gttcagcgtt cagatgataa tgcagatgca 540
ctgaaaaaac gtctggccgc ctatcataag ctgaccgaac cggttgtgga tttttataaa 600
aaaaccggta tttgggcggg cgttgatgcg agtcagccgc cggccaccgt ttgggccgat 660
attctgaata aactgggtaa agat                                        684

 
<210> 848
<211> 228
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Engineered Variant  of Adenylate kinase from Saccharomyces cerevisiae 
 
<400> 848
Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      
Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          
Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              
Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  
Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  
Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      
Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         
Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             
Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 
Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 
Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     
Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Leu Thr 
            180                 185                 190         
Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             
Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 
Leu Gly Lys Asp                                                 
225             

