                         SEQUENCE LISTING

<110>  Schmidt, Darby  Rye
       Nagarajan, Niranjana Aditi
       Kaiser, William  Joseph
       Gough, Peter Joseph
       Dhakal, Sabin
       Hubaud, Alexis Benoit
 
<120>  THANOTRANSMISSION POLYPEPTIDES AND THEIR USE IN TREATING CANCER

<130>  129983-01220

<150>  US 63/169,167
<151>  2021-03-31

<150>  US 63/216,499
<151>  2021-06-29

<150>  US 63/292,667
<151>  2021-12-22

<160>  32   

<170>  PatentIn version 3.5

<210>  1
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcttgca caggaccttc tctgcccagc gcctttgata tcctgggagc cgctggacag       60

gacaagctgc tgtacctgaa gcacaagctg aaaacccctc ggcctggctg ccagggacaa      120

gatctgctgc atgctatggt gctgctgaag ctgggccaag agacagaggc cagaatcagc      180

ctggaagccc tgaaggctga tgccgtggct agactggttg ccagacaatg ggctggcgtg      240

gacagcacag aggaccctga agaacctcct gacgtgtcct gggccgtcgc cagactgtat      300

catctgctgg ccgaagagaa gctgtgcccc gcctctctga gagatgtggc ctatcaagaa      360

gccgtgcgga ccctgagcag cagggatgat catagactgg gcgagctgca ggacgaggcc      420

cggaatagat gtggctggga tattgctggc gaccccggca gcattagaac cctgcagtct      480

aacctgggct gcctgcctcc atcttctgcc ctgccatctg gcacaagaag cctgcctaga      540

cctatcgacg gcgtgtccga ttggagccag ggctgttctc tgagaagcac aggatctcca      600

gccagcctgg ccagcaacct ggaaatcagc cagtctccta caatgccctt cctgagcctg      660

cacagaagcc ctcacggacc tagcaagctg tgcgacgatc ctcaggcttc tctggtgcct      720

gaacctgttc ctggcggctg ccaagagcct gaagagatgt cttggcctcc tagcggcgag      780

atcgcctctc cacctgaact gccatctagc cctccaccag gactgcctga agtggcccct      840

gatgccactt ctacaggcct gcctgataca cccgccgctc cagagacaag cacaaactac      900

cctgtggaat gcaccgaggg ctctgccgga cctcaatctc tgcctctgcc tatcctggaa      960

cctgtgaaga acccttgcag cgtgaaggat cagacccctc tgcagctgag cgtggaagat     1020

accacctctc ctaacaccaa gccttgtcct ccaacaccta ccacacctga gacaagccca     1080

cctcctccgc ctccaccacc aagctctaca ccttgtagcg cccacctgac accaagcagc     1140

ctgtttccaa gctctctgga aagcagcagc gagcagaaat tctacaactt cgtgatcctg     1200

cacgccagag ccgacgagca cattgccctg agagtgcgcg aaaagctgga agctctggga     1260

gtgcctgatg gcgccacctt ctgcgaggat tttcaggttc ccggaagagg cgagctgagc     1320

tgtctgcagg atgccatcga tcacagcgcc ttcatcattc tgctgctgac cagcaacttc     1380

gactgccggc tgtctctgca ccaagtgaac caggccatga tgagcaacct gaccagacag     1440

ggcagccccg attgcgtgat cccattcctg ccactggaaa gctccccagc acagctgtct     1500

agcgatactg cctctctgct gtctggactc gtgcggctgg atgagcacag ccagatcttc     1560

gccagaaagg tggccaacac cttcaagccc catcggctgc aggccagaaa agccatgtgg     1620

cggaaagagc aggacacacg ggcactgaga gagcagtctc agcacctgga tggcgagaga     1680

atgcaggccg ctgctctgaa tgccgcctac agcgcttacc tgcagagcta cctgagctat     1740

caggcccaga tggaacagct gcaggtcgcc tttggcagcc acatgtcctt tggaacaggc     1800

gccccttacg gcgccagaat gccttttggt ggacaggtgc cactgggagc ccctccacct     1860

tttccaacat ggccaggatg tccccagcct cctccactgc atgcttggca agctggaaca     1920

cctccgccac catctccaca gccagctgcc tttccacagt ctctcccatt tccacagagc     1980

cccgcctttc caacagctag ccctgctcct ccacaaagcc ctggactgca gcccctgatc     2040

attcaccacg cacagatggt gcagctggga ctgaacaatc acatgtggaa ccagagaggc     2100

tctcaggccc ctgaggacaa gacacaagag gccgaatga                            2139


<210>  2
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ser Gln Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
    530                 535                 540                 


Asp Thr Arg Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg 
545                 550                 555                 560 


Met Gln Ala Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser 
                565                 570                 575     


Tyr Leu Ser Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly 
            580                 585                 590         


Ser His Met Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro 
        595                 600                 605             


Phe Gly Gly Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp 
    610                 615                 620                 


Pro Gly Cys Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr 
625                 630                 635                 640 


Pro Pro Pro Pro Ser Pro Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro 
                645                 650                 655     


Phe Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln 
            660                 665                 670         


Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln 
        675                 680                 685             


Leu Gly Leu Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro 
    690                 695                 700                 


Glu Asp Lys Thr Gln Glu Ala Glu 
705                 710         


<210>  3
<211>  2139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation of the RHIM tetrad of TRIF into AAAA

<400>  3
atggcttgca caggaccttc tctgcccagc gcctttgata tcctgggagc cgctggacag       60

gacaagctgc tgtacctgaa gcacaagctg aaaacccctc ggcctggctg ccagggacaa      120

gatctgctgc atgctatggt gctgctgaag ctgggccaag agacagaggc cagaatcagc      180

ctggaagccc tgaaggctga tgccgtggct agactggttg ccagacaatg ggctggcgtg      240

gacagcacag aggaccctga agaacctcct gacgtgtcct gggccgtcgc cagactgtat      300

catctgctgg ccgaagagaa gctgtgcccc gcctctctga gagatgtggc ctatcaagaa      360

gccgtgcgga ccctgagcag cagggatgat catagactgg gcgagctgca ggacgaggcc      420

cggaatagat gtggctggga tattgctggc gaccccggca gcattagaac cctgcagtct      480

aacctgggct gcctgcctcc atcttctgcc ctgccatctg gcacaagaag cctgcctaga      540

cctatcgacg gcgtgtccga ttggagccag ggctgttctc tgagaagcac aggatctcca      600

gccagcctgg ccagcaacct ggaaatcagc cagtctccta caatgccctt cctgagcctg      660

cacagaagcc ctcacggacc tagcaagctg tgcgacgatc ctcaggcttc tctggtgcct      720

gaacctgttc ctggcggctg ccaagagcct gaagagatgt cttggcctcc tagcggcgag      780

atcgcctctc cacctgaact gccatctagc cctccaccag gactgcctga agtggcccct      840

gatgccactt ctacaggcct gcctgataca cccgccgctc cagagacaag cacaaactac      900

cctgtggaat gcaccgaggg ctctgccgga cctcaatctc tgcctctgcc tatcctggaa      960

cctgtgaaga acccttgcag cgtgaaggat cagacccctc tgcagctgag cgtggaagat     1020

accacctctc ctaacaccaa gccttgtcct ccaacaccta ccacacctga gacaagccca     1080

cctcctccgc ctccaccacc aagctctaca ccttgtagcg cccacctgac accaagcagc     1140

ctgtttccaa gctctctgga aagcagcagc gagcagaaat tctacaactt cgtgatcctg     1200

cacgccagag ccgacgagca cattgccctg agagtgcgcg aaaagctgga agctctggga     1260

gtgcctgatg gcgccacctt ctgcgaggat tttcaggttc ccggaagagg cgagctgagc     1320

tgtctgcagg atgccatcga tcacagcgcc ttcatcattc tgctgctgac cagcaacttc     1380

gactgccggc tgtctctgca ccaagtgaac caggccatga tgagcaacct gaccagacag     1440

ggcagccccg attgcgtgat cccattcctg ccactggaaa gctccccagc acagctgtct     1500

agcgatactg cctctctgct gtctggactc gtgcggctgg atgagcacag ccagatcttc     1560

gccagaaagg tggccaacac cttcaagccc catcggctgc aggccagaaa agccatgtgg     1620

cggaaagagc aggacacacg ggcactgaga gagcagtctc agcacctgga tggcgagaga     1680

atgcaggccg ctgctctgaa tgccgcctac agcgcttacc tgcagagcta cctgagctat     1740

caggcccaga tggaacagct gcaggtcgcc tttggcagcc acatgtcctt tggaacaggc     1800

gccccttacg gcgccagaat gccttttggt ggacaggtgc cactgggagc ccctccacct     1860

tttccaacat ggccaggatg tccccagcct cctccactgc atgcttggca agctggaaca     1920

cctccgccac catctccaca gccagctgcc tttccacagt ctctcccatt tccacagagc     1980

cccgcctttc caacagctag ccctgctcct ccacaaagcc ctggactgca gcccctgatc     2040

attcaccacg cacagatggt ggcagcggcc gctaacaatc acatgtggaa ccagagaggc     2100

tctcaggccc ctgaggacaa gacacaagag gccgaatga                            2139


<210>  4
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutation of the RHIM tetrad of TRIF into AAAA

<400>  4

Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ser Gln Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
    530                 535                 540                 


Asp Thr Arg Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg 
545                 550                 555                 560 


Met Gln Ala Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser 
                565                 570                 575     


Tyr Leu Ser Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly 
            580                 585                 590         


Ser His Met Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro 
        595                 600                 605             


Phe Gly Gly Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp 
    610                 615                 620                 


Pro Gly Cys Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr 
625                 630                 635                 640 


Pro Pro Pro Pro Ser Pro Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro 
                645                 650                 655     


Phe Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln 
            660                 665                 670         


Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Ala 
        675                 680                 685             


Ala Ala Ala Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro 
    690                 695                 700                 


Glu Asp Lys Thr Gln Glu Ala Glu 
705                 710         


<210>  5
<211>  1623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncation of the C-ter fragment (541-712) of TRIF containing the RHIM 
       domain

<400>  5
atggcttgca caggaccttc tctgcccagc gcctttgata tcctgggagc cgctggacag       60

gacaagctgc tgtacctgaa gcacaagctg aaaacccctc ggcctggctg ccagggacaa      120

gatctgctgc atgctatggt gctgctgaag ctgggccaag agacagaggc cagaatcagc      180

ctggaagccc tgaaggctga tgccgtggct agactggttg ccagacaatg ggctggcgtg      240

gacagcacag aggaccctga agaacctcct gacgtgtcct gggccgtcgc cagactgtat      300

catctgctgg ccgaagagaa gctgtgcccc gcctctctga gagatgtggc ctatcaagaa      360

gccgtgcgga ccctgagcag cagggatgat catagactgg gcgagctgca ggacgaggcc      420

cggaatagat gtggctggga tattgctggc gaccccggca gcattagaac cctgcagtct      480

aacctgggct gcctgcctcc atcttctgcc ctgccatctg gcacaagaag cctgcctaga      540

cctatcgacg gcgtgtccga ttggagccag ggctgttctc tgagaagcac aggatctcca      600

gccagcctgg ccagcaacct ggaaatcagc cagtctccta caatgccctt cctgagcctg      660

cacagaagcc ctcacggacc tagcaagctg tgcgacgatc ctcaggcttc tctggtgcct      720

gaacctgttc ctggcggctg ccaagagcct gaagagatgt cttggcctcc tagcggcgag      780

atcgcctctc cacctgaact gccatctagc cctccaccag gactgcctga agtggcccct      840

gatgccactt ctacaggcct gcctgataca cccgccgctc cagagacaag cacaaactac      900

cctgtggaat gcaccgaggg ctctgccgga cctcaatctc tgcctctgcc tatcctggaa      960

cctgtgaaga acccttgcag cgtgaaggat cagacccctc tgcagctgag cgtggaagat     1020

accacctctc ctaacaccaa gccttgtcct ccaacaccta ccacacctga gacaagccca     1080

cctcctccgc ctccaccacc aagctctaca ccttgtagcg cccacctgac accaagcagc     1140

ctgtttccaa gctctctgga aagcagcagc gagcagaaat tctacaactt cgtgatcctg     1200

cacgccagag ccgacgagca cattgccctg agagtgcgcg aaaagctgga agctctggga     1260

gtgcctgatg gcgccacctt ctgcgaggat tttcaggttc ccggaagagg cgagctgagc     1320

tgtctgcagg atgccatcga tcacagcgcc ttcatcattc tgctgctgac cagcaacttc     1380

gactgccggc tgtctctgca ccaagtgaac caggccatga tgagcaacct gaccagacag     1440

ggcagccccg attgcgtgat cccattcctg ccactggaaa gctccccagc acagctgtct     1500

agcgatactg cctctctgct gtctggactc gtgcggctgg atgagcacag ccagatcttc     1560

gccagaaagg tggccaacac cttcaagccc catcggctgc aggccagaaa agccatgtgg     1620

tga                                                                   1623


<210>  6
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncation of the C-ter fragment (541-712) of TRIF containing the RHIM 
       domain

<400>  6

Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ser Gln Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp 
    530                 535                 540 


<210>  7
<211>  2139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutations for TBK1 phosphorylation sites (S210A,S212A,T214A) of TRIF

<400>  7
atggcttgca caggaccttc tctgcccagc gcctttgata tcctgggagc cgctggacag       60

gacaagctgc tgtacctgaa gcacaagctg aaaacccctc ggcctggctg ccagggacaa      120

gatctgctgc atgctatggt gctgctgaag ctgggccaag agacagaggc cagaatcagc      180

ctggaagccc tgaaggctga tgccgtggct agactggttg ccagacaatg ggctggcgtg      240

gacagcacag aggaccctga agaacctcct gacgtgtcct gggccgtcgc cagactgtat      300

catctgctgg ccgaagagaa gctgtgcccc gcctctctga gagatgtggc ctatcaagaa      360

gccgtgcgga ccctgagcag cagggatgat catagactgg gcgagctgca ggacgaggcc      420

cggaatagat gtggctggga tattgctggc gaccccggca gcattagaac cctgcagtct      480

aacctgggct gcctgcctcc atcttctgcc ctgccatctg gcacaagaag cctgcctaga      540

cctatcgacg gcgtgtccga ttggagccag ggctgttctc tgagaagcac aggatctcca      600

gccagcctgg ccagcaacct ggaaatcgca caggctcctg ccatgccctt cctgagcctg      660

cacagaagcc ctcacggacc tagcaagctg tgcgacgatc ctcaggcttc tctggtgcct      720

gaacctgttc ctggcggctg ccaagagcct gaagagatgt cttggcctcc tagcggcgag      780

atcgcctctc cacctgaact gccatctagc cctccaccag gactgcctga agtggcccct      840

gatgccactt ctacaggcct gcctgataca cccgccgctc cagagacaag cacaaactac      900

cctgtggaat gcaccgaggg ctctgccgga cctcaatctc tgcctctgcc tatcctggaa      960

cctgtgaaga acccttgcag cgtgaaggat cagacccctc tgcagctgag cgtggaagat     1020

accacctctc ctaacaccaa gccttgtcct ccaacaccta ccacacctga gacaagccca     1080

cctcctccgc ctccaccacc aagctctaca ccttgtagcg cccacctgac accaagcagc     1140

ctgtttccaa gctctctgga aagcagcagc gagcagaaat tctacaactt cgtgatcctg     1200

cacgccagag ccgacgagca cattgccctg agagtgcgcg aaaagctgga agctctggga     1260

gtgcctgatg gcgccacctt ctgcgaggat tttcaggttc ccggaagagg cgagctgagc     1320

tgtctgcagg atgccatcga tcacagcgcc ttcatcattc tgctgctgac cagcaacttc     1380

gactgccggc tgtctctgca ccaagtgaac caggccatga tgagcaacct gaccagacag     1440

ggcagccccg attgcgtgat cccattcctg ccactggaaa gctccccagc acagctgtct     1500

agcgatactg cctctctgct gtctggactc gtgcggctgg atgagcacag ccagatcttc     1560

gccagaaagg tggccaacac cttcaagccc catcggctgc aggccagaaa agccatgtgg     1620

cggaaagagc aggacacacg ggcactgaga gagcagtctc agcacctgga tggcgagaga     1680

atgcaggccg ctgctctgaa tgccgcctac agcgcttacc tgcagagcta cctgagctat     1740

caggcccaga tggaacagct gcaggtcgcc tttggcagcc acatgtcctt tggaacaggc     1800

gccccttacg gcgccagaat gccttttggt ggacaggtgc cactgggagc ccctccacct     1860

tttccaacat ggccaggatg tccccagcct cctccactgc atgcttggca agctggaaca     1920

cctccgccac catctccaca gccagctgcc tttccacagt ctctcccatt tccacagagc     1980

cccgcctttc caacagctag ccctgctcct ccacaaagcc ctggactgca gcccctgatc     2040

attcaccacg cacagatggt gcagctggga ctgaacaatc acatgtggaa ccagagaggc     2100

tctcaggccc ctgaggacaa gacacaagag gccgaatga                            2139


<210>  8
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutations for TBK1 phosphorylation sites (S210A,S212A,T214A) of TRIF

<400>  8

Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ala Gln Ala Pro Ala Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
    530                 535                 540                 


Asp Thr Arg Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg 
545                 550                 555                 560 


Met Gln Ala Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser 
                565                 570                 575     


Tyr Leu Ser Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly 
            580                 585                 590         


Ser His Met Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro 
        595                 600                 605             


Phe Gly Gly Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp 
    610                 615                 620                 


Pro Gly Cys Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr 
625                 630                 635                 640 


Pro Pro Pro Pro Ser Pro Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro 
                645                 650                 655     


Phe Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln 
            660                 665                 670         


Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln 
        675                 680                 685             


Leu Gly Leu Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro 
    690                 695                 700                 


Glu Asp Lys Thr Gln Glu Ala Glu 
705                 710         


<210>  9
<211>  2139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutation for dimerization site P434 in the TIR domain of TRIF

<400>  9
atggcttgca caggaccttc tctgcccagc gcctttgata tcctgggagc cgctggacag       60

gacaagctgc tgtacctgaa gcacaagctg aaaacccctc ggcctggctg ccagggacaa      120

gatctgctgc atgctatggt gctgctgaag ctgggccaag agacagaggc cagaatcagc      180

ctggaagccc tgaaggctga tgccgtggct agactggttg ccagacaatg ggctggcgtg      240

gacagcacag aggaccctga agaacctcct gacgtgtcct gggccgtcgc cagactgtat      300

catctgctgg ccgaagagaa gctgtgcccc gcctctctga gagatgtggc ctatcaagaa      360

gccgtgcgga ccctgagcag cagggatgat catagactgg gcgagctgca ggacgaggcc      420

cggaatagat gtggctggga tattgctggc gaccccggca gcattagaac cctgcagtct      480

aacctgggct gcctgcctcc atcttctgcc ctgccatctg gcacaagaag cctgcctaga      540

cctatcgacg gcgtgtccga ttggagccag ggctgttctc tgagaagcac aggatctcca      600

gccagcctgg ccagcaacct ggaaatcagc cagtctccta caatgccctt cctgagcctg      660

cacagaagcc ctcacggacc tagcaagctg tgcgacgatc ctcaggcttc tctggtgcct      720

gaacctgttc ctggcggctg ccaagagcct gaagagatgt cttggcctcc tagcggcgag      780

atcgcctctc cacctgaact gccatctagc cctccaccag gactgcctga agtggcccct      840

gatgccactt ctacaggcct gcctgataca cccgccgctc cagagacaag cacaaactac      900

cctgtggaat gcaccgaggg ctctgccgga cctcaatctc tgcctctgcc tatcctggaa      960

cctgtgaaga acccttgcag cgtgaaggat cagacccctc tgcagctgag cgtggaagat     1020

accacctctc ctaacaccaa gccttgtcct ccaacaccta ccacacctga gacaagccca     1080

cctcctccgc ctccaccacc aagctctaca ccttgtagcg cccacctgac accaagcagc     1140

ctgtttccaa gctctctgga aagcagcagc gagcagaaat tctacaactt cgtgatcctg     1200

cacgccagag ccgacgagca cattgccctg agagtgcgcg aaaagctgga agctctggga     1260

gtgcctgatg gcgccacctt ctgcgaggat tttcaggttc atggaagagg cgagctgagc     1320

tgtctgcagg atgccatcga tcacagcgcc ttcatcattc tgctgctgac cagcaacttc     1380

gactgccggc tgtctctgca ccaagtgaac caggccatga tgagcaacct gaccagacag     1440

ggcagccccg attgcgtgat cccattcctg ccactggaaa gctccccagc acagctgtct     1500

agcgatactg cctctctgct gtctggactc gtgcggctgg atgagcacag ccagatcttc     1560

gccagaaagg tggccaacac cttcaagccc catcggctgc aggccagaaa agccatgtgg     1620

cggaaagagc aggacacacg ggcactgaga gagcagtctc agcacctgga tggcgagaga     1680

atgcaggccg ctgctctgaa tgccgcctac agcgcttacc tgcagagcta cctgagctat     1740

caggcccaga tggaacagct gcaggtcgcc tttggcagcc acatgtcctt tggaacaggc     1800

gccccttacg gcgccagaat gccttttggt ggacaggtgc cactgggagc ccctccacct     1860

tttccaacat ggccaggatg tccccagcct cctccactgc atgcttggca agctggaaca     1920

cctccgccac catctccaca gccagctgcc tttccacagt ctctcccatt tccacagagc     1980

cccgcctttc caacagctag ccctgctcct ccacaaagcc ctggactgca gcccctgatc     2040

attcaccacg cacagatggt gcagctggga ctgaacaatc acatgtggaa ccagagaggc     2100

tctcaggccc ctgaggacaa gacacaagag gccgaatga                            2139


<210>  10
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutation for dimerization site P434 in the TIR domain of TRIF

<400>  10

Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ser Gln Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val His Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
    530                 535                 540                 


Asp Thr Arg Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg 
545                 550                 555                 560 


Met Gln Ala Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser 
                565                 570                 575     


Tyr Leu Ser Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly 
            580                 585                 590         


Ser His Met Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro 
        595                 600                 605             


Phe Gly Gly Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp 
    610                 615                 620                 


Pro Gly Cys Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr 
625                 630                 635                 640 


Pro Pro Pro Pro Ser Pro Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro 
                645                 650                 655     


Phe Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln 
            660                 665                 670         


Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln 
        675                 680                 685             


Leu Gly Leu Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro 
    690                 695                 700                 


Glu Asp Lys Thr Gln Glu Ala Glu 
705                 710         


<210>  11
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miniTRIF

<400>  11
atgcagtctc tgcccctgcc tatcctggaa cctgtgaaga acccctgcag cgtgaaggat       60

cagacccctc tgcagctgag cgtggaagat accacctctc ctaacaccaa gccttgtcct      120

ccaacaccta ccacacctga gacaagccct ccacctccgc ctccaccacc aagctctaca      180

ccttgtagcg cccacctgac accaagcagc ctgtttccat ccagcctgga aagcagcagc      240

gagcagaaat tctacaactt cgtgatcctg cacgccagag ccgacgagca cattgccctg      300

agagtgcgcg aaaagctgga agccctggga gttcctgatg gcgccacctt ctgcgaggat      360

ttccaagtgc ctggaagagg cgagctgagc tgtctgcagg atgccatcga tcacagcgcc      420

ttcatcatcc tgctgctgac cagcaacttc gactgcagac tgagcctgca ccaagtgaac      480

caggccatga tgagcaacct gaccagacag ggcagccccg attgcgtgat cccattcctg      540

cctctggaaa gctcccctgc tcagctgtct agcgatacag cctctctgct gtctggactc      600

gtgcggctgg atgagcacag ccagatcttc gccagaaagg tggccaacac cttcaagccc      660

catcggctgc aggccagaaa agccatgtgg cggaaagagc aggacacacg ggctctgaga      720

gagcagtctc agcacctgga tggcgagaga atgcaggccg ctgctctgaa tgccgcctac      780

tctgcctacc tgcagagcta cctgagctat caggcccaga tggaacagct gcaggtcgcc      840

tttggcagcc acatgtcctt tggaacaggc gccccttacg gcgccagaat gccttttggt      900

ggacaggtgc cactgggagc ccctccacca tttcctacat ggccaggatg tccccagcct      960

cctccactgc atgcttggca agctggaaca ccacctcctc catctccaca gcctgccgcc     1020

tttccacaga gcctgccttt tccacagtct cccgcttttc ccaccgcctc tccagctcca     1080

ccacaatctc caggactgca gcccctgatc atccaccacg ctcaaatggt gcagctggga     1140

ctgaacaatc acatgtggaa ccagcggggc tctcaggccc ctgaggataa gacacaagag     1200

gccgagtga                                                             1209


<210>  12
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  miniTRIF

<400>  12

Met Gln Ser Leu Pro Leu Pro Ile Leu Glu Pro Val Lys Asn Pro Cys 
1               5                   10                  15      


Ser Val Lys Asp Gln Thr Pro Leu Gln Leu Ser Val Glu Asp Thr Thr 
            20                  25                  30          


Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr Pro Thr Thr Pro Glu Thr 
        35                  40                  45              


Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Thr Pro Cys Ser Ala 
    50                  55                  60                  


His Leu Thr Pro Ser Ser Leu Phe Pro Ser Ser Leu Glu Ser Ser Ser 
65                  70                  75                  80  


Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu His Ala Arg Ala Asp Glu 
                85                  90                  95      


His Ile Ala Leu Arg Val Arg Glu Lys Leu Glu Ala Leu Gly Val Pro 
            100                 105                 110         


Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln Val Pro Gly Arg Gly Glu 
        115                 120                 125             


Leu Ser Cys Leu Gln Asp Ala Ile Asp His Ser Ala Phe Ile Ile Leu 
    130                 135                 140                 


Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu Ser Leu His Gln Val Asn 
145                 150                 155                 160 


Gln Ala Met Met Ser Asn Leu Thr Arg Gln Gly Ser Pro Asp Cys Val 
                165                 170                 175     


Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro Ala Gln Leu Ser Ser Asp 
            180                 185                 190         


Thr Ala Ser Leu Leu Ser Gly Leu Val Arg Leu Asp Glu His Ser Gln 
        195                 200                 205             


Ile Phe Ala Arg Lys Val Ala Asn Thr Phe Lys Pro His Arg Leu Gln 
    210                 215                 220                 


Ala Arg Lys Ala Met Trp Arg Lys Glu Gln Asp Thr Arg Ala Leu Arg 
225                 230                 235                 240 


Glu Gln Ser Gln His Leu Asp Gly Glu Arg Met Gln Ala Ala Ala Leu 
                245                 250                 255     


Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser Tyr Leu Ser Tyr Gln Ala 
            260                 265                 270         


Gln Met Glu Gln Leu Gln Val Ala Phe Gly Ser His Met Ser Phe Gly 
        275                 280                 285             


Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro Phe Gly Gly Gln Val Pro 
    290                 295                 300                 


Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp Pro Gly Cys Pro Gln Pro 
305                 310                 315                 320 


Pro Pro Leu His Ala Trp Gln Ala Gly Thr Pro Pro Pro Pro Ser Pro 
                325                 330                 335     


Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro Phe Pro Gln Ser Pro Ala 
            340                 345                 350         


Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln Ser Pro Gly Leu Gln Pro 
        355                 360                 365             


Leu Ile Ile His His Ala Gln Met Val Gln Leu Gly Leu Asn Asn His 
    370                 375                 380                 


Met Trp Asn Gln Arg Gly Ser Gln Ala Pro Glu Asp Lys Thr Gln Glu 
385                 390                 395                 400 


Ala Glu 
        


<210>  13
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N-ter deletion (1-180) of TRIF

<400>  13
atgcccatcg acggcgtgtc cgattggagc cagggctgtt ctctgcggag caccggcagc       60

cctgccagcc tggcctctaa cctggaaatc agccaaagcc ccaccatgcc attcctgtct      120

cttcacagaa gtccgcacgg ccctagcaag ctgtgcgacg acccccaggc tagcctggtg      180

ccagaacctg tgcctggcgg ctgccaggag cctgaggaaa tgagctggcc tccttctggc      240

gagatcgcct ccccgcccga gctgcctagc tctcctcctc ccggcctgcc tgaagtggct      300

cctgatgcca cttctacagg actgcctgat acacccgccg cacccgaaac cagcaccaac      360

taccccgtgg aatgcaccga gggctcagcc ggcccccaat ctctccctct gcctatcctg      420

gagcccgtga aaaacccttg cagcgtgaag gaccagaccc ctctgcagct gagcgtggag      480

gataccacaa gccccaacac aaagccctgt ccccctaccc ccacaacacc tgagacaagc      540

ccaccacctc ctcctccacc tcctagcagt accccttgta gcgcccatct gaccccatca      600

agcctgttcc ctagctctct agagagcagc agtgaacaaa agttctacaa cttcgtgatc      660

ctgcacgcca gagccgacga gcacatcgcc ctgagagtgc gggaaaagct ggaggccctg      720

ggtgtgcctg acggcgccac cttctgcgag gacttccagg tccctggcag aggcgagctg      780

tcctgtctgc aagacgccat cgaccactct gccttcatca tcctgctgct gacctccaat      840

ttcgactgcc ggctgagcct ccaccaggtt aatcaggcca tgatgagcaa cctgacaaga      900

cagggcagcc ccgactgcgt gatccctttc ctgcctctgg aaagcagccc tgcccaactg      960

tcgtctgata cagccagcct gctgagcggc ctggtcagac tggacgagca cagccagatt     1020

ttcgccagaa aagtggccaa caccttcaag cctcaccggc tgcaggcccg gaaagccatg     1080

tggcggaagg aacaggacac cagagccctg agagagcaga gccagcacct ggatggcgaa     1140

agaatgcagg ccgctgccct gaatgccgcc tacagcgcct acctgcagag ctacctgtct     1200

tatcaggccc agatggaaca gctgcaggtg gcttttggca gccacatgtc cttcggcacc     1260

ggcgctcctt acggtgccag gatgcccttc ggaggccagg tgccactggg agcccctcct     1320

ccttttccta cctggcccgg ctgcccccaa cctccacctc tgcatgcttg gcaagctgga     1380

acacctccac caccttctcc aaagcctgcc gcatttcccc agtccctgcc ttttcctcag     1440

agccctgctt tcccaaccgc cagcccagct cctccccaga gccctggact gcagcctctg     1500

atcatccacc acgcccagat ggtgcagctc ggactgaaca accacatgtg gaaccagaga     1560

ggctctcagg ctcctgagga caagacacag gaggccgagt ga                        1602


<210>  14
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-ter deletion (1-180) of TRIF

<400>  14

Met Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys Ser Leu Arg 
1               5                   10                  15      


Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu Ile Ser Gln 
            20                  25                  30          


Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro His Gly Pro 
        35                  40                  45              


Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro Glu Pro Val 
    50                  55                  60                  


Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro Pro Ser Gly 
65                  70                  75                  80  


Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro Pro Gly Leu 
                85                  90                  95      


Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro Asp Thr Pro 
            100                 105                 110         


Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys Thr Glu Gly 
        115                 120                 125             


Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu Pro Val Lys 
    130                 135                 140                 


Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu Ser Val Glu 
145                 150                 155                 160 


Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr Pro Thr Thr 
                165                 170                 175     


Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser Ser Thr Pro 
            180                 185                 190         


Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser Ser Leu Glu 
        195                 200                 205             


Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu His Ala Arg 
    210                 215                 220                 


Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu Glu Ala Leu 
225                 230                 235                 240 


Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln Val Pro Gly 
                245                 250                 255     


Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His Ser Ala Phe 
            260                 265                 270         


Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu Ser Leu His 
        275                 280                 285             


Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln Gly Ser Pro 
    290                 295                 300                 


Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro Ala Gln Leu 
305                 310                 315                 320 


Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg Leu Asp Glu 
                325                 330                 335     


His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe Lys Pro His 
            340                 345                 350         


Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln Asp Thr Arg 
        355                 360                 365             


Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg Met Gln Ala 
    370                 375                 380                 


Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser Tyr Leu Ser 
385                 390                 395                 400 


Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly Ser His Met 
                405                 410                 415     


Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro Phe Gly Gly 
            420                 425                 430         


Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp Pro Gly Cys 
        435                 440                 445             


Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr Pro Pro Pro 
    450                 455                 460                 


Pro Ser Pro Lys Pro Ala Ala Phe Pro Gln Ser Leu Pro Phe Pro Gln 
465                 470                 475                 480 


Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln Ser Pro Gly 
                485                 490                 495     


Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln Leu Gly Leu 
            500                 505                 510         


Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro Glu Asp Lys 
        515                 520                 525             


Thr Gln Glu Ala Glu 
    530             


<210>  15
<211>  483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment 387-544 of TRIF

<400>  15
atggagtcta gcagcgagca gaaattctac aacttcgtga tcctgcacgc cagagccgac       60

gagcacattg ccctgagagt gcgcgaaaag ctggaagccc tgggagttcc tgatggcgcc      120

accttctgcg aggatttcca agtgcctgga agaggcgagc tgagctgtct gcaggatgcc      180

atcgatcaca gcgccttcat catcctgctg ctgaccagca acttcgactg cagactgagc      240

ctgcaccaag tgaaccaggc catgatgagc aacctgacca gacagggcag ccccgattgc      300

gtgatcccat tcctgcctct ggaaagcagc cctgctcagc tgtctagcga tacagcctct      360

ctgctgtctg gactcgtgcg gctggatgag cacagccaga tcttcgccag aaaggtggcc      420

aacaccttca agccccatcg gctgcaggcc agaaaagcca tgtggcggaa agagcaggac      480

tga                                                                    483


<210>  16
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment 387-544 of TRIF

<400>  16

Met Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu His 
1               5                   10                  15      


Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu Glu 
            20                  25                  30          


Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln Val 
        35                  40                  45              


Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His Ser 
    50                  55                  60                  


Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu Ser 
65                  70                  75                  80  


Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln Gly 
                85                  90                  95      


Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro Ala 
            100                 105                 110         


Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg Leu 
        115                 120                 125             


Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe Lys 
    130                 135                 140                 


Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
145                 150                 155                 


<210>  17
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Deletion of N-ter fragment 1-180 and fragment 217-658 of TRIF

<400>  17
atgcctatcg acggcgtgtc cgactggtcc caaggctgca gcctgagaag caccggcagc       60

cctgctagcc tggcctctaa tctggaaatc agccaatctc caacaatgcc ccagagccct      120

gccttcccca ccgccagccc agctcctcct cagtctcccg gcctgcagcc tctgatcatc      180

caccacgccc agatggtgca gctgggcctg aacaaccaca tgtggaacca gcggggaagc      240

caggcccctg aggacaaaac ccaggaggcc gaatga                                276


<210>  18
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Deletion of N-ter fragment 1-180 and fragment 217-658 of TRIF

<400>  18

Met Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys Ser Leu Arg 
1               5                   10                  15      


Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu Ile Ser Gln 
            20                  25                  30          


Ser Pro Thr Met Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala 
        35                  40                  45              


Pro Pro Gln Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln 
    50                  55                  60                  


Met Val Gln Leu Gly Leu Asn Asn His Met Trp Asn Gln Arg Gly Ser 
65                  70                  75                  80  


Gln Ala Pro Glu Asp Lys Thr Gln Glu Ala Glu 
                85                  90      


<210>  19
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Deletion of N-ter fragment 1-180, fragment 217-386 and fragment 
       546-712 of TRIF

<400>  19
atgcctatcg acggagtgtc cgactggtcc cagggatgta gccttagaag caccggcagc       60

cctgctagcc tggcctctaa cctggaaatc agccagagcc ctacaatgcc agagagcagc      120

agcgagcaga aattctacaa cttcgtgatt ctgcacgcca gagccgacga gcacatcgcc      180

ctgagagtgc gggaaaagct ggaggccctg ggcgtgcctg atggcgccac cttctgcgaa      240

gattttcagg tccccggcag aggcgagctg agctgcctgc aggacgctat cgaccacagc      300

gccttcatca tcctgctgct gacaagcaac ttcgactgca ggctgagcct gcaccaggtg      360

aaccaggcca tgatgagcaa tctgaccaga cagggctccc cagattgcgt gatccccttc      420

ctgcctctgg agagctctcc tgcacagctg tcttctgaca ccgccagcct gctctccggc      480

ctggtgcggc tggacgagca ttctcaaatc ttcgccagaa aagtggccaa cacctttaag      540

ccccacagac tgcaagctcg gaaggccatg tggcggaagg aacaggattg a               591


<210>  20
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Deletion of N-ter fragment 1-180, fragment 217-386 and fragment 
       546-712 of TRIF

<400>  20

Met Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys Ser Leu Arg 
1               5                   10                  15      


Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu Ile Ser Gln 
            20                  25                  30          


Ser Pro Thr Met Pro Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe 
        35                  40                  45              


Val Ile Leu His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg 
    50                  55                  60                  


Glu Lys Leu Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu 
65                  70                  75                  80  


Asp Phe Gln Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala 
                85                  90                  95      


Ile Asp His Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp 
            100                 105                 110         


Cys Arg Leu Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu 
        115                 120                 125             


Thr Arg Gln Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu 
    130                 135                 140                 


Ser Ser Pro Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly 
145                 150                 155                 160 


Leu Val Arg Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala 
                165                 170                 175     


Asn Thr Phe Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg 
            180                 185                 190         


Lys Glu Gln 
        195 


<210>  21
<211>  2166
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRIR RIPK3

<400>  21
atgcctatcg acggcgtgtc cgattggagc cagggatgtt ctctgcggag cacaggctct       60

cccgcctctc tggccagcaa cctggaaatc agccaatctc ctaccatgcc cgaaagctct      120

tctgagcaga agttctacaa ctttgtgatc ctgcacgccc gggccgacga gcacatcgcc      180

ctgagagtgc gggaaaagct ggaagccctg ggcgtgcccg acggcgcaac attttgtgaa      240

gatttccagg ttcctggtag aggagagctt tcctgtctgc aagacgccat tgaccacagc      300

gccttcatca tcctgctgct gacatctaac ttcgactgca gactgtccct gcaccaggtg      360

aatcaggcca tgatgagcaa tctgaccaga cagggcagcc ctgactgcgt gatccccttc      420

ctgccactgg aaagcagccc tgctcagctg agtagcgaca ccgccagcct gctcagcggc      480

ctggtcagac tggacgaaca ctctcaaatc ttcgccagaa aagtggctaa taccttcaag      540

ccccaccggc tgcaggccag aaaggctatg tggcggaaag aacaggatgg ccccggcgga      600

tccagcggca gcagctgcgt caaactgtgg cctagcggcg cccctgcccc tctggtgtcc      660

atcgaggaac tggaaaacca agagcttgtc ggcaagggcg gcttcggcac tgttttcaga      720

gctcaacaca gaaagtgggg ctacgacgtg gccgtgaaga tcgtgaacag caaggccatc      780

agcagagaag tgaaggccat ggccagcctg gacaacgagt tcgtgctgag actggaggga      840

gtgatcgaga aggtgaactg ggaccaggat cctaaacccg ccctggtgac aaagttcatg      900

gaaaacggca gcctgagcgg actgctgcag agccaatgtc ctagaccttg gcccctgctg      960

tgccggctcc tgaaggaagt ggtgctcggc atgttctacc tgcatgatca gaatcccgtg     1020

ctgctgcaca gagatctgaa accctccaac gtgctgctgg atcctgagct gcacgtgaag     1080

ctggccgatt tcggcctgag cacctttcag ggcggcagtc agagcggcac aggcagcggc     1140

gagcctggcg gcaccctggg ctacctggct cctgagctgt tcgtgaatgt gaatcggaag     1200

gccagcacag cttctgacgt gtatagcttt ggcatcctga tgtgggccgt gctggctgga     1260

agggaagttg agctgcccac cgagcccagc ctggtgtacg aggccgtgtg caaccggcag     1320

aaccggccaa gcctggccga gctgcctcag gctggccctg agacacctgg ccttgagggc     1380

ctgaaggagc tcatgcagct gtgctggagc tccgagccaa aggacagacc atctttccag     1440

gagtgcctgc ctaagaccga cgaggtgttc cagatggtgg aaaacaacat gaacgccgcc     1500

gtcagcaccg tgaaggactt tctgagccag ctgagatctt ccaatagacg cttcagcatc     1560

cctgagtctg gacagggagg aacagagatg gacggattcc ggagaaccat cgagaaccag     1620

cactcccgga acgacgtgat ggtcagcgag tggctgaaca agctgaacct ggaagagcct     1680

ccaagctcag tgcccaagaa gtgcccctct ctgaccaaaa gaagcagagc ccaggaggaa     1740

caggtgcctc aggcctggac cgccggaaca agcagcgaca gcatggccca gcctccgcaa     1800

acacctgaaa ccagcacctt cagaaaccag atgcctagcc ccaccagcac cggcacccct     1860

tcccctggcc ccagaggcaa ccagggcgca gagcggcagg gcatgaactg gtcctgccgc     1920

acccccgagc ccaaccctgt gaccggccgg cctctggtga acatctacaa ctgcagcggt     1980

gtgcaggtgg gtgataacaa ttacctgacc atgcagcaga ccaccgctct gccaacatgg     2040

ggcctcgccc cttctggcaa gggcagaggc ctgcagcatc ctcctcctgt gggctctcag     2100

gaaggaccta aggaccccga ggcctggagc aggcctcagg gctggtacaa ccactcaggc     2160

aaatga                                                                2166


<210>  22
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIR RIPK3

<400>  22

Met Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys Ser Leu Arg 
1               5                   10                  15      


Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu Ile Ser Gln 
            20                  25                  30          


Ser Pro Thr Met Pro Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe 
        35                  40                  45              


Val Ile Leu His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg 
    50                  55                  60                  


Glu Lys Leu Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu 
65                  70                  75                  80  


Asp Phe Gln Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala 
                85                  90                  95      


Ile Asp His Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp 
            100                 105                 110         


Cys Arg Leu Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu 
        115                 120                 125             


Thr Arg Gln Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu 
    130                 135                 140                 


Ser Ser Pro Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly 
145                 150                 155                 160 


Leu Val Arg Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala 
                165                 170                 175     


Asn Thr Phe Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg 
            180                 185                 190         


Lys Glu Gln Asp Gly Pro Gly Gly Ser Ser Gly Ser Ser Cys Val Lys 
        195                 200                 205             


Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val Ser Ile Glu Glu Leu 
    210                 215                 220                 


Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe Gly Thr Val Phe Arg 
225                 230                 235                 240 


Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala Val Lys Ile Val Asn 
                245                 250                 255     


Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met Ala Ser Leu Asp Asn 
            260                 265                 270         


Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu Lys Val Asn Trp Asp 
        275                 280                 285             


Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe Met Glu Asn Gly Ser 
    290                 295                 300                 


Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg Pro Trp Pro Leu Leu 
305                 310                 315                 320 


Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met Phe Tyr Leu His Asp 
                325                 330                 335     


Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys Pro Ser Asn Val Leu 
            340                 345                 350         


Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp Phe Gly Leu Ser Thr 
        355                 360                 365             


Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser Gly Glu Pro Gly Gly 
    370                 375                 380                 


Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val Asn Val Asn Arg Lys 
385                 390                 395                 400 


Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly Ile Leu Met Trp Ala 
                405                 410                 415     


Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr Glu Pro Ser Leu Val 
            420                 425                 430         


Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro Ser Leu Ala Glu Leu 
        435                 440                 445             


Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu Gly Leu Lys Glu Leu 
    450                 455                 460                 


Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp Arg Pro Ser Phe Gln 
465                 470                 475                 480 


Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln Met Val Glu Asn Asn 
                485                 490                 495     


Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe Leu Ser Gln Leu Arg 
            500                 505                 510         


Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser Gly Gln Gly Gly Thr 
        515                 520                 525             


Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn Gln His Ser Arg Asn 
    530                 535                 540                 


Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu Asn Leu Glu Glu Pro 
545                 550                 555                 560 


Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu Thr Lys Arg Ser Arg 
                565                 570                 575     


Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr Ala Gly Thr Ser Ser 
            580                 585                 590         


Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu Thr Ser Thr Phe Arg 
        595                 600                 605             


Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr Pro Ser Pro Gly Pro 
    610                 615                 620                 


Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met Asn Trp Ser Cys Arg 
625                 630                 635                 640 


Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro Leu Val Asn Ile Tyr 
                645                 650                 655     


Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn Tyr Leu Thr Met Gln 
            660                 665                 670         


Gln Thr Thr Ala Leu Pro Thr Trp Gly Leu Ala Pro Ser Gly Lys Gly 
        675                 680                 685             


Arg Gly Leu Gln His Pro Pro Pro Val Gly Ser Gln Glu Gly Pro Lys 
    690                 695                 700                 


Asp Pro Glu Ala Trp Ser Arg Pro Gln Gly Trp Tyr Asn His Ser Gly 
705                 710                 715                 720 


Lys 
    


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  23
gactacaagg acgacgacga caag                                              24


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  24

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Gly Pro Gly Gly Ser Ser Gly Ser Ser 
1               5                   

<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide

<400>  26

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        

<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide

<400>  27

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide

<400>  28

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  29
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide

<400>  29

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  30
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     


Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         


Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             


Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 


Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     


Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         


Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             


Leu Val Asn Ile Tyr Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn 
    450                 455                 460                 


Tyr Leu Thr Met Gln Gln Thr Thr Ala Leu Pro Thr Trp Gly Leu Ala 
465                 470                 475                 480 


Pro Ser Gly Lys Gly Arg Gly Leu Gln His Pro Pro Pro Val Gly Ser 
                485                 490                 495     


Gln Glu Gly Pro Lys Asp Pro Glu Ala Trp Ser Arg Pro Gln Gly Trp 
            500                 505                 510         


Tyr Asn His Ser Gly Lys 
        515             


<210>  31
<211>  1557
<212>  DNA
<213>  Homo sapiens

<400>  31
atgtcgtgcg tcaagttatg gcccagcggt gcccccgccc ccttggtgtc catcgaggaa       60

ctggagaacc aggagctcgt cggcaaaggc gggttcggca cagtgttccg ggcgcaacat      120

aggaagtggg gctacgatgt ggcggtcaag atcgtaaact cgaaggcgat atccagggag      180

gtcaaggcca tggcaagtct ggataacgaa ttcgtgctgc gcctagaagg ggttatcgag      240

aaggtgaact gggaccaaga tcccaagccg gctctggtga ctaaattcat ggagaacggc      300

tccttgtcgg ggctgctgca gtcccagtgc cctcggccct ggccgctcct ttgccgcctg      360

ctgaaagaag tggtgcttgg gatgttttac ctgcacgacc agaacccggt gctcctgcac      420

cgggacctca agccatccaa cgtcctgctg gacccagagc tgcacgtcaa gctggcagat      480

tttggcctgt ccacatttca gggaggctca cagtcaggga cagggtccgg ggagccaggg      540

ggcaccctgg gctacttggc cccagaactg tttgttaacg taaaccggaa ggcctccaca      600

gccagtgacg tctacagctt cgggatccta atgtgggcag tgcttgctgg aagagaagtt      660

gagttgccaa ccgaaccatc actcgtgtac gaagcagtgt gcaacaggca gaaccggcct      720

tcattggctg agctgcccca agccgggcct gagactcccg gcttagaagg actgaaggag      780

ctaatgcagc tctgctggag cagtgagccc aaggacagac cctccttcca ggaatgccta      840

ccaaaaactg atgaagtctt ccagatggtg gagaacaata tgaatgctgc tgtctccacg      900

gtaaaggatt tcctgtctca gctcaggagc agcaatagga gattttctat cccagagtca      960

ggccaaggag ggacagaaat ggatggcttt aggagaacca tagaaaacca gcactctcgt     1020

aatgatgtca tggtttctga gtggctaaac aaactgaatc tagaggagcc tcccagctct     1080

gttcctaaaa aatgcccgag ccttaccaag aggagcaggg cacaagagga gcaggttcca     1140

caagcctgga cagcaggcac atcttcagat tcgatggccc aacctcccca gactccagag     1200

acctcaactt tcagaaacca gatgcccagc cctacctcaa ctggaacacc aagtcctgga     1260

ccccgaggga atcagggggc tgagagacaa ggcatgaact ggtcctgcag gaccccggag     1320

ccaaatccag taacagggcg accgctcgtt aacatataca actgctctgg ggtgcaagtt     1380

ggagacaaca actacttgac tatgcaacag acaactgcct tgcccacatg gggcttggca     1440

ccttcgggca aggggagggg cttgcagcac cccccaccag taggttcgca agaaggccct     1500

aaagatcctg aagcctggag caggccacag ggttggtata atcatagcgg gaaataa        1557


<210>  32
<211>  476
<212>  PRT
<213>  Herpes virus

<400>  32

Met Asp Asp Leu Arg Asp Thr Leu Met Ala Tyr Gly Cys Ile Ala Ile 
1               5                   10                  15      


Arg Ala Gly Asp Phe Asn Gly Leu Asn Asp Phe Leu Glu Gln Glu Cys 
            20                  25                  30          


Gly Thr Arg Leu His Val Ala Trp Pro Glu Arg Cys Phe Ile Gln Leu 
        35                  40                  45              


Arg Ser Arg Ser Ala Leu Gly Pro Phe Val Gly Lys Met Gly Thr Val 
    50                  55                  60                  


Cys Ser Gln Gly Ala Tyr Val Cys Cys Gln Glu Tyr Leu His Pro Phe 
65                  70                  75                  80  


Gly Phe Val Glu Gly Pro Gly Phe Met Arg Tyr Gln Leu Ile Val Leu 
                85                  90                  95      


Ile Gly Gln Arg Gly Gly Ile Tyr Cys Tyr Asp Asp Leu Arg Asp Cys 
            100                 105                 110         


Ile Tyr Glu Leu Ala Pro Thr Met Lys Asp Phe Leu Arg His Gly Phe 
        115                 120                 125             


Arg His Cys Asp His Phe His Thr Met Arg Asp Tyr Gln Arg Pro Met 
    130                 135                 140                 


Val Gln Tyr Asp Asp Tyr Trp Asn Ala Val Met Leu Tyr Arg Gly Asp 
145                 150                 155                 160 


Val Glu Ser Leu Ser Ala Glu Val Thr Lys Arg Gly Tyr Ala Ser Tyr 
                165                 170                 175     


Ser Ile Asp Asp Pro Phe Asp Glu Cys Pro Asp Thr His Phe Ala Phe 
            180                 185                 190         


Trp Thr His Asn Thr Glu Val Met Lys Phe Lys Glu Thr Ser Phe Ser 
        195                 200                 205             


Val Val Arg Ala Gly Gly Ser Ile Gln Thr Met Glu Leu Met Ile Arg 
    210                 215                 220                 


Thr Val Pro Arg Ile Thr Cys Tyr His Gln Leu Leu Gly Ala Leu Gly 
225                 230                 235                 240 


His Glu Val Pro Glu Arg Lys Glu Phe Leu Val Arg Gln Tyr Val Leu 
                245                 250                 255     


Val Asp Thr Phe Gly Val Val Tyr Gly Tyr Asp Pro Ala Met Asp Ala 
            260                 265                 270         


Val Tyr Arg Leu Ala Glu Asp Val Val Met Phe Thr Cys Val Met Gly 
        275                 280                 285             


Lys Lys Gly His Arg Asn His Arg Phe Ser Gly Arg Arg Glu Ala Ile 
    290                 295                 300                 


Val Arg Leu Glu Lys Thr Pro Thr Cys Gln His Pro Lys Lys Thr Pro 
305                 310                 315                 320 


Asp Pro Met Ile Met Phe Asp Glu Asp Asp Asp Asp Glu Leu Ser Leu 
                325                 330                 335     


Pro Arg Asn Val Met Thr His Glu Glu Ala Glu Ser Arg Leu Tyr Asp 
            340                 345                 350         


Ala Ile Thr Glu Asn Leu Met His Cys Val Lys Leu Val Thr Thr Asp 
        355                 360                 365             


Ser Pro Leu Ala Thr His Leu Trp Pro Gln Glu Leu Gln Ala Leu Cys 
    370                 375                 380                 


Asp Ser Pro Ala Leu Ser Leu Cys Thr Asp Asp Val Glu Gly Val Arg 
385                 390                 395                 400 


Gln Lys Leu Arg Ala Arg Thr Gly Ser Leu His His Phe Glu Leu Ser 
                405                 410                 415     


Tyr Arg Phe His Asp Glu Asp Pro Glu Thr Tyr Met Gly Phe Leu Trp 
            420                 425                 430         


Asp Ile Pro Ser Cys Asp Arg Cys Val Arg Arg Arg Arg Phe Lys Val 
        435                 440                 445             


Cys Asp Val Gly Arg Arg His Ile Ile Pro Gly Ala Ala Asn Gly Met 
    450                 455                 460                 


Pro Pro Leu Thr Pro Pro His Ala Tyr Met Asn Asn 
465                 470                 475     

