
                                SEQUENCE LISTING

<110> Prelude Corporation
      Stenmark Tullberg, Axel Emanuel
      Holmberg, Erik Carl Viktor
      Karlsson, Per Oswald
      Bremer, Troy M.

<120> PD-L1 AS A PREDICTIVE MARKER FOR THERAPY
  IN CANCER

<130> PRLUD.011WO

<150> 63/169,517          
<151> 2021-04-01  

<150> 63/264,018          
<151> 2021-11-12  

<150> 63/264,144          
<151> 2021-11-16  

<160> 5

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 288
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
 1               5                  10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly
                165                 170                 175     
Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys
            180                 185                 190         
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro
        195                 200                 205             
Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly
    210                 215                 220                 
Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro
225                 230                 235                 240 
Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly
                245                 250                 255     
Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg
            260                 265                 270         
Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu
        275                 280                 285             


<210> 2
<211> 290
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser
65                  70                  75                  80  
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn
                85                  90                  95      
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr
            100                 105                 110         
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val
        115                 120                 125             
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val
    130                 135                 140                 
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr
145                 150                 155                 160 
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser
                165                 170                 175     
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn
            180                 185                 190         
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr
        195                 200                 205             
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu
    210                 215                 220                 
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His
225                 230                 235                 240 
Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr
                245                 250                 255     
Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys
            260                 265                 270         
Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu
        275                 280                 285             
Glu Thr
    290 


<210> 3
<211> 176
<212> PRT
<213> Homo sapiens

<400> 3
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
            20                  25                  30          
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
        35                  40                  45              
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
    50                  55                  60                  
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
65                  70                  75                  80  
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
                85                  90                  95      
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
            100                 105                 110         
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val
        115                 120                 125             
Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile
    130                 135                 140                 
Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile
145                 150                 155                 160 
Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr
                165                 170                 175     


<210> 4
<211> 3634
<212> RNA
<213> Homo sapiens

<400> 4
agttctgcgc agcttcccga ggctccgcac cagccgcgct tctgtccgcc tgcagggcat 60
tccagaaaga tgaggatatt tgctgtcttt atattcatga cctactggca tttgctgaac 120
gcatttactg tcacggttcc caaggaccta tatgtggtag agtatggtag caatatgaca 180
attgaatgca aattcccagt agaaaaacaa ttagacctgg ctgcactaat tgtctattgg 240
gaaatggagg ataagaacat tattcaattt gtgcatggag aggaagacct gaaggttcag 300
catagtagct acagacagag ggcccggctg ttgaaggacc agctctccct gggaaatgct 360
gcacttcaga tcacagatgt gaaattgcag gatgcagggg tgtaccgctg catgatcagc 420
tatggtggtg ccgactacaa gcgaattact gtgaaagtca atgccccata caacaaaatc 480
aaccaaagaa ttttggttgt ggatccagtc acctctgaac atgaactgac atgtcaggct 540
gagggctacc ccaaggccga agtcatctgg acaagcagtg accatcaagt cctgagtggt 600
aagaccacca ccaccaattc caagagagag gagaagcttt tcaatgtgac cagcacactg 660
agaatcaaca caacaactaa tgagattttc tactgcactt ttaggagatt agatcctgag 720
gaaaaccata cagctgaatt ggtcatccca gaactacctc tggcacatcc tccaaatgaa 780
aggactcact tggtaattct gggagccatc ttattatgcc ttggtgtagc actgacattc 840
atcttccgtt taagaaaagg gagaatgatg gatgtgaaaa aatgtggcat ccaagataca 900
aactcaaaga agcaaagtga tacacatttg gaggagacgt aatccagcat tggaacttct 960
gatcttcaag cagggattct caacctgtgg tttaggggtt catcggggct gagcgtgaca 1020
agaggaagga atgggcccgt gggatgcagg caatgtggga cttaaaaggc ccaagcactg 1080
aaaatggaac ctggcgaaag cagaggagga gaatgaagaa agatggagtc aaacagggag 1140
cctggaggga gaccttgata ctttcaaatg cctgaggggc tcatcgacgc ctgtgacagg 1200
gagaaaggat acttctgaac aaggagcctc caagcaaatc atccattgct catcctagga 1260
agacgggttg agaatcccta atttgagggt cagttcctgc agaagtgccc tttgcctcca 1320
ctcaatgcct caatttgttt tctgcatgac tgagagtctc agtgttggaa cgggacagta 1380
tttatgtatg agtttttcct atttattttg agtctgtgag gtcttcttgt catgtgagtg 1440
tggttgtgaa tgatttcttt tgaagatata ttgtagtaga tgttacaatt ttgtcgccaa 1500
actaaacttg ctgcttaatg atttgctcac atctagtaaa acatggagta tttgtaaggt 1560
gcttggtctc ctctataact acaagtatac attggaagca taaagatcaa accgttggtt 1620
gcataggatg tcacctttat ttaacccatt aatactctgg ttgacctaat cttattctca 1680
gacctcaagt gtctgtgcag tatctgttcc atttaaatat cagctttaca attatgtggt 1740
agcctacaca cataatctca tttcatcgct gtaaccaccc tgttgtgata accactatta 1800
ttttacccat cgtacagctg aggaagcaaa cagattaagt aacttgccca aaccagtaaa 1860
tagcagacct cagactgcca cccactgtcc ttttataata caatttacag ctatatttta 1920
ctttaagcaa ttcttttatt caaaaaccat ttattaagtg cccttgcaat atcaatcgct 1980
gtgccaggca ttgaatctac agatgtgagc aagacaaagt acctgtcctc aaggagctca 2040
tagtataatg aggagattaa caagaaaatg tattattaca atttagtcca gtgtcatagc 2100
ataaggatga tgcgagggga aaacccgagc agtgttgcca agaggaggaa ataggccaat 2160
gtggtctggg acggttggat atacttaaac atcttaataa tcagagtaat tttcatttac 2220
aaagagaggt cggtacttaa aataaccctg aaaaataaca ctggaattcc ttttctagca 2280
ttatatttat tcctgatttg cctttgccat ataatctaat gcttgtttat atagtgtctg 2340
gtattgttta acagttctgt cttttctatt taaatgccac taaattttaa attcatacct 2400
ttccatgatt caaaattcaa aagatcccat gggagatggt tggaaaatct ccacttcatc 2460
ctccaagcca ttcaagtttc ctttccagaa gcaactgcta ctgcctttca ttcatatgtt 2520
cttctaaaga tagtctacat ttggaaatgt atgttaaaag cacgtatttt taaaattttt 2580
ttcctaaata gtaacacatt gtatgtctgc tgtgtacttt gctattttta tttattttag 2640
tgtttcttat atagcagatg gaatgaattt gaagttccca gggctgagga tccatgcctt 2700
ctttgtttct aagttatctt tcccatagct tttcattatc tttcatatga tccagtatat 2760
gttaaatatg tcctacatat acatttagac aaccaccatt tgttaagtat ttgctctagg 2820
acagagtttg gatttgttta tgtttgctca aaaggagacc catgggctct ccagggtgca 2880
ctgagtcaat ctagtcctaa aaagcaatct tattattaac tctgtatgac agaatcatgt 2940
ctggaacttt tgttttctgc tttctgtcaa gtataaactt cactttgatg ctgtacttgc 3000
aaaatcacat tttctttctg gaaattccgg cagtgtacct tgactgctag ctaccctgtg 3060
ccagaaaagc ctcattcgtt gtgcttgaac ccttgaatgc caccagctgt catcactaca 3120
cagccctcct aagaggcttc ctggaggttt cgagattcag atgccctggg agatcccaga 3180
gtttcctttc cctcttggcc atattctggt gtcaatgaca aggagtacct tggctttgcc 3240
acatgtcaag gctgaagaaa cagtgtctcc aacagagctc cttgtgttat ctgtttgtac 3300
atgtgcattt gtacagtaat tggtgtgaca gtgttctttg tgtgaattac aggcaagaat 3360
tgtggctgag caaggcacat agtctactca gtctattcct aagtcctaac tcctccttgt 3420
ggtgttggat ttgtaaggca ctttatccct tttgtctcat gtttcatcgt aaatggcata 3480
ggcagagatg atacctaatt ctgcatttga ttgtcacttt ttgtacctgc attaatttaa 3540
taaaatattc ttatttattt tgttacttgg tacaccagca tgtccatttt cttgtttatt 3600
ttgtgtttaa taaaatgttc agtttaacat ccca                             3634

<210> 5
<211> 3292
<212> RNA
<213> Homo sapiens

<400> 5
agttctgcgc agcttcccga ggctccgcac cagccgcgct tctgtccgcc tgcagggcat 60
tccagaaaga tgaggatatt tgctgtcttt atattcatga cctactggca tttgctgaac 120
gccccataca acaaaatcaa ccaaagaatt ttggttgtgg atccagtcac ctctgaacat 180
gaactgacat gtcaggctga gggctacccc aaggccgaag tcatctggac aagcagtgac 240
catcaagtcc tgagtggtaa gaccaccacc accaattcca agagagagga gaagcttttc 300
aatgtgacca gcacactgag aatcaacaca acaactaatg agattttcta ctgcactttt 360
aggagattag atcctgagga aaaccataca gctgaattgg tcatcccaga actacctctg 420
gcacatcctc caaatgaaag gactcacttg gtaattctgg gagccatctt attatgcctt 480
ggtgtagcac tgacattcat cttccgttta agaaaaggga gaatgatgga tgtgaaaaaa 540
tgtggcatcc aagatacaaa ctcaaagaag caaagtgata cacatttgga ggagacgtaa 600
tccagcattg gaacttctga tcttcaagca gggattctca acctgtggtt taggggttca 660
tcggggctga gcgtgacaag aggaaggaat gggcccgtgg gatgcaggca atgtgggact 720
taaaaggccc aagcactgaa aatggaacct ggcgaaagca gaggaggaga atgaagaaag 780
atggagtcaa acagggagcc tggagggaga ccttgatact ttcaaatgcc tgaggggctc 840
atcgacgcct gtgacaggga gaaaggatac ttctgaacaa ggagcctcca agcaaatcat 900
ccattgctca tcctaggaag acgggttgag aatccctaat ttgagggtca gttcctgcag 960
aagtgccctt tgcctccact caatgcctca atttgttttc tgcatgactg agagtctcag 1020
tgttggaacg ggacagtatt tatgtatgag tttttcctat ttattttgag tctgtgaggt 1080
cttcttgtca tgtgagtgtg gttgtgaatg atttcttttg aagatatatt gtagtagatg 1140
ttacaatttt gtcgccaaac taaacttgct gcttaatgat ttgctcacat ctagtaaaac 1200
atggagtatt tgtaaggtgc ttggtctcct ctataactac aagtatacat tggaagcata 1260
aagatcaaac cgttggttgc ataggatgtc acctttattt aacccattaa tactctggtt 1320
gacctaatct tattctcaga cctcaagtgt ctgtgcagta tctgttccat ttaaatatca 1380
gctttacaat tatgtggtag cctacacaca taatctcatt tcatcgctgt aaccaccctg 1440
ttgtgataac cactattatt ttacccatcg tacagctgag gaagcaaaca gattaagtaa 1500
cttgcccaaa ccagtaaata gcagacctca gactgccacc cactgtcctt ttataataca 1560
atttacagct atattttact ttaagcaatt cttttattca aaaaccattt attaagtgcc 1620
cttgcaatat caatcgctgt gccaggcatt gaatctacag atgtgagcaa gacaaagtac 1680
ctgtcctcaa ggagctcata gtataatgag gagattaaca agaaaatgta ttattacaat 1740
ttagtccagt gtcatagcat aaggatgatg cgaggggaaa acccgagcag tgttgccaag 1800
aggaggaaat aggccaatgt ggtctgggac ggttggatat acttaaacat cttaataatc 1860
agagtaattt tcatttacaa agagaggtcg gtacttaaaa taaccctgaa aaataacact 1920
ggaattcctt ttctagcatt atatttattc ctgatttgcc tttgccatat aatctaatgc 1980
ttgtttatat agtgtctggt attgtttaac agttctgtct tttctattta aatgccacta 2040
aattttaaat tcataccttt ccatgattca aaattcaaaa gatcccatgg gagatggttg 2100
gaaaatctcc acttcatcct ccaagccatt caagtttcct ttccagaagc aactgctact 2160
gcctttcatt catatgttct tctaaagata gtctacattt ggaaatgtat gttaaaagca 2220
cgtattttta aaattttttt cctaaatagt aacacattgt atgtctgctg tgtactttgc 2280
tatttttatt tattttagtg tttcttatat agcagatgga atgaatttga agttcccagg 2340
gctgaggatc catgccttct ttgtttctaa gttatctttc ccatagcttt tcattatctt 2400
tcatatgatc cagtatatgt taaatatgtc ctacatatac atttagacaa ccaccatttg 2460
ttaagtattt gctctaggac agagtttgga tttgtttatg tttgctcaaa aggagaccca 2520
tgggctctcc agggtgcact gagtcaatct agtcctaaaa agcaatctta ttattaactc 2580
tgtatgacag aatcatgtct ggaacttttg ttttctgctt tctgtcaagt ataaacttca 2640
ctttgatgct gtacttgcaa aatcacattt tctttctgga aattccggca gtgtaccttg 2700
actgctagct accctgtgcc agaaaagcct cattcgttgt gcttgaaccc ttgaatgcca 2760
ccagctgtca tcactacaca gccctcctaa gaggcttcct ggaggtttcg agattcagat 2820
gccctgggag atcccagagt ttcctttccc tcttggccat attctggtgt caatgacaag 2880
gagtaccttg gctttgccac atgtcaaggc tgaagaaaca gtgtctccaa cagagctcct 2940
tgtgttatct gtttgtacat gtgcatttgt acagtaattg gtgtgacagt gttctttgtg 3000
tgaattacag gcaagaattg tggctgagca aggcacatag tctactcagt ctattcctaa 3060
gtcctaactc ctccttgtgg tgttggattt gtaaggcact ttatcccttt tgtctcatgt 3120
ttcatcgtaa atggcatagg cagagatgat acctaattct gcatttgatt gtcacttttt 3180
gtacctgcat taatttaata aaatattctt atttattttg ttacttggta caccagcatg 3240
tccattttct tgtttatttt gtgtttaata aaatgttcag tttaacatcc ca         3292
