                         SEQUENCE LISTING

<110>  Protagonist Therapeutics, Inc.
 
<120>  CONJUGATED HEPCIDIN MIMETICS

<130>  PRTH-064/01WO 321085-2521

<140>  PCT/US2022/022817
<141>  2022-03-31

<150>  US 63/169,545
<151>  2021-04-01

<150>  US 63/325,328
<151>  2022-03-30

<160>  133   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  side chain C of Ala at position 4 and side chain C of Ala at 
       position 6 cyclized via -CH=CH- (S/S isomer); No CH2 between 
       sidechain carbons of alanine and carbon vinyl group

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  1

Glu Thr His Ala Pro Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  side chain C of Ala at 4 and side chain C of Ala at 6 cyclized 
       via CH2-CH=CH- (S/S isomer); One CH2 between sidechain carbon of 
       alanine at 4 and carbon vinyl group, and no CH2 between sidechain
       carbon of alanine at 6 and vinyl group

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  2

Glu Thr His Ala Pro Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  side chain C of Ala at 6 and side chain C of Ala at 8 cyclized 
       via -CH=CH-CH2- (S/S isomer); no CH2 between sidechain carbon of 
       alanine at 6 and vinyl group, and one CH2 between sidechain 
       carbon of alanine at 8 and carbon vinyl group

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  3

Glu Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  side chain C of Ala at 4 and side chain C of Ala at 6 cyclized 
       via -CH=CH-CH2- (S/S isomer); no CH2 between sidechain carbon of 
       alanine at 4 and vinyl group, and one CH2 between sidechain 
       carbon of alanine at 6 and carbon vinyl group

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  4

Glu Thr His Ala Pro Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  side chain C of Ala at 4 and side chain C of Ala at 6 cyclized 
       via CH2-CH=CH-CH2- (S/S isomer); One CH2 between sidechain 
       carbons of alanines and carbon vinyl group

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  5

Glu Thr His Ala Pro Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(8)
<223>  side chain C of Ala at 6 and side chain C of Ala at 8 cyclized 
       via CH2-CH=CH-CH2- (S/S isomer); One CH2 between sidechain carbon
       of alanines and vinyl group

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  6

Glu Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  side chain C of Ala at 4 and side chain C of Ala at 6 cyclized 
       via -CH2CH2-CH2- (S/S isomer); no CH2 between sidechain carbon of
       alanine at 4 and vinyl group, and one CH2 between sidechain 
       carbon of alanine at 6 and carbon vinyl group

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  7

Glu Thr His Ala Pro Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain C of Ala at 5 and side chain C of Ala at 6 cyclized 
       via -CH=CH- (S/S isomer); No CH2 between sidechain carbon of 
       alanines and vinyl group

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  8

Glu Thr His Xaa Ala Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain C of Ala at 5 and side chain C of Ala at 6 cyclized 
       via -CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  9

Glu Thr His Xaa Ala Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain C of Ala at 5 and side chain C of Ala at 6 cyclized 
       via -CH2-CH=CH- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  10

Glu Thr His Xaa Ala Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  side chain C of Ala at 5 and side chain C of Ala at 6 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  11

Glu Thr His Xaa Ala Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  side chain C of Ala at 6 and side chain C of Ala at 7 cyclized 
       via --CH=CH-(S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  12

Glu Thr His Xaa Pro Ala Ala Lys Xaa Lys Lys 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  side chain C of Ala at 6 and side chain C of Ala at 7 cyclized 
       via -CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  13

Glu Thr His Xaa Pro Ala Ala Lys Xaa Lys Lys 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  side chain C of Ala at 6 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  14

Glu Thr His Xaa Pro Ala Ala Lys Xaa Lys Lys 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  side chain C of Ala at 6 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  15

Glu Thr His Xaa Pro Ala Ala Lys Xaa Lys Lys 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  16

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<400>  17

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys 
1               5                   10  


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<400>  18

Ala Thr His Xaa Pro Ala Ile Ala Lys 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain C of Ala at 1 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<400>  19

Ala Thr His Xaa Pro Ile Ala Xaa Lys 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  side chain C of Ala at 1 and side chain C of Ala at 6 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<400>  20

Ala Thr His Xaa Pro Ala Xaa Lys 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  side chain C of Ala at 1 and side chain C of Ala at 6 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_Palm conjugation

<400>  21

Ala Thr His Xaa Pro Ala Lys 
1               5           


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<400>  22

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Arg 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<400>  23

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Arg 
1               5                   10      


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<400>  24

Ala Thr His Xaa Pro Lys Ile Ala Xaa 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<400>  25

Ala Thr His Xaa Pro Ala Lys Ala Xaa 
1               5                   


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  26

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via via -CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  27

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  28

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  29

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2--CH2-CH=CH- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  30

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  31

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH=CH-CH2-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  32

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  33

Ala Thr His Xaa Pro Lys Ile Ala Xaa Lys 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  34

Ala Thr His Xaa Pro Ala Lys Ala Xaa Lys 
1               5                   10  


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain C of Ala at 1 and side chain C of Ala at 7 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form Lysine

<400>  35

Ala Thr His Xaa Pro Lys Ala Xaa Lys 
1               5                   


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  36

Ala Thr His Xaa Pro Lys Ile Ala Xaa Lys 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  37

Ala Thr His Xaa Pro Ala Lys Ala Xaa Lys 
1               5                   10  


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain C of Ala at 1 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form Lysine

<400>  38

Ala Thr His Xaa Pro Lys Ala Xaa Lys 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Ahx_Palm conjugation

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  39

Ala Thr His Xaa Pro Ala Lys Ala Xaa Lys 
1               5                   10  


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain C of Ala at 1 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form Lysine

<400>  40

Ala Thr His Xaa Pro Lys Ala Xaa Lys 
1               5                   


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  41

Ala Ala His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  42

Ala Thr Ala Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  43

Ala Thr His Ala Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  44

Ala Thr His Xaa Ala Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  45

Ala Thr His Xaa Pro Ala Ala Ala Xaa Lys Lys 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  46

Ala Thr His Xaa Pro Ala Ile Ala Ala Lys Lys 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  47

Ala Thr His Xaa Pro Ala Ile Ala Xaa Ala Lys 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<400>  48

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Ala 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa in N-Methyl-Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  49

Ala Xaa His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  50

Ala Thr Xaa Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  51

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is N-Methyl-Alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  52

Ala Thr His Xaa Pro Xaa Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is N-Methyl-Leucine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  53

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Lys Lys 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  54

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is N-Methyl-Lysine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  55

Ala Thr His Xaa Pro Ala Ile Ala Xaa Xaa Lys 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in N-Methyl-Histidine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form N-Methyl-Lysine

<400>  56

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Xaa 
1               5                   10      


<210>  57

<400>  57
000

<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa in tert-butyl-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  58

Ala Xaa His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa in tert-butyl-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  59

Ala Thr Xaa Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is ter-butyl-alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  60

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is tert-butyl-alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  61

Ala Thr His Xaa Xaa Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is tert-butyl-alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  62

Ala Thr His Xaa Pro Xaa Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is tert-butyl-alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Phenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  63

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Lys Lys 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is tert-butyl-alanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  64

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is tert-butyl-alanine

<400>  65

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Xaa 
1               5                   10      


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain C of Ala at 1 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH-CH2- (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is  gama-aminobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  66

Ala Thr His Xaa Pro Xaa Ala Xaa Lys Lys 
1               5                   10  


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2-CH2 (R/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  67

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (R/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  68

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2- (R/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  69

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2- (R/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  70

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2-CH2- (R/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  71

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (R/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  72

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH--CH2-CH2- (R/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  73

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  R chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2- (R/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  74

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2-CH2- (S/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  75

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2- (S/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  76

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2- (S/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  77

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-  (S/R isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  R-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  78

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  79

Ala Thr His Xaa Pro Cys Ile Ala Xaa Lys Lys Cys 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH2-CH=CH-CH2-CH2  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  80

Ala Thr His Xaa Pro Cys Ile Ala Xaa Lys Lys Cys 
1               5                   10          


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  side chain C of Ala at 1 and side chain C of Ala at 6 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  81

Ala Thr His Xaa Pro Ala Ile Lys Xaa Lys Lys 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  side chain C of Ala at 1 and side chain C of Ala at 7 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  82

Ala Thr His Xaa Pro Ala Ala Lys Xaa Lys Lys 
1               5                   10      


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  side chain C of Ala at 1 and side chain C of Ala at 9 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  83

Ala Thr His Xaa Pro Ala Ile Lys Ala Lys Lys 
1               5                   10      


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  side chain C of Ala at 1 and side chain C of Ala at 11 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  S chirality

<400>  84

Ala Thr His Xaa Pro Ala Ile Lys Xaa Lys Ala 
1               5                   10      


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  side chain C of Ala at 1 and side chain C of Ala at 8 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Lysine

<400>  85

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  S chirality

<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  side chain C of Ala at 1 and side chain C of Ala at 6 cyclized 
       via -CH2-CH=CH-CH2-  (S/S isomer)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  S-chirality

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Ahx_Palm conjugation

<400>  86

Ala Thr His Xaa Pro Ala Xaa Lys 
1               5               


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -CH2CH=CHCH2-trans linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  87

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  88

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)6- linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  89

Ala Thr His Xaa Pro Lys Ile Ala Xaa Lys 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)4- linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  90

Ala Thr His Xaa Pro Lys Ile Ala Xaa Lys 
1               5                   10  


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  91

Ala Thr His Xaa Pro Ala Xaa Xaa Xaa Lys Arg 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  92

Ala Thr His Xaa Pro Ala Xaa Xaa Xaa Lys Arg 
1               5                   10      


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  93

Ala Thr His Xaa Pro Ala Xaa Xaa Xaa Lys Arg 
1               5                   10      


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  94

Ala Thr His Xaa Pro Lys Xaa Xaa Xaa Arg 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  95

Ala Thr His Xaa Pro Lys Xaa Xaa Xaa Arg 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  96

Ala Thr His Xaa Pro Lys Xaa Xaa Xaa Arg 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to alpha-methyl-Ala 
       at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  97

Ala Thr His Xaa Pro Lys Xaa Xaa Xaa Arg 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2- linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is tert-Leucine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  98

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to alpha-methyl-Ala at 
       8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is alpha-methyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  99

Ala Thr His Xaa Pro Lys Xaa Xaa Xaa Arg 
1               5                   10  


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is sarcosine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  100

Ala Thr His Xaa Pro Xaa Xaa Ala Xaa Lys Arg 
1               5                   10      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  101

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Lys Arg 
1               5                   10      


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is tert-Leucine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  102

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Lys Arg 
1               5                   10      


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is tert-leucine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  103

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine psi

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  104

Ala Thr His Xaa Pro Ala Ile Ala Xaa Arg 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2-  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Histidine-psi

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  105

Ala Thr Xaa Xaa Pro Ala Ile Ala Xaa Arg 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2C(=CH2)C(=CH2)(CH2)2-  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Threonine-psi

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  106

Ala Xaa His Xaa Pro Ala Ile Ala Xaa Arg 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  107

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  108

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  109

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is (S)-2-amino-4,4-dimethylpentanoic acid

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  110

Ala Thr His Xaa Pro Lys Xaa Ala Xaa Arg 
1               5                   10  


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_IsoGlu_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  111

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Arg 
1               5                   10      


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_IsoGlu_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  112

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Arg 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  1PEG2_1PEG2_Ahx_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  113

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Arg 
1               5                   10      


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2- trans  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form Arginine

<400>  114

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Arg 
1               5                   10      


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  115

Ala Thr His Xaa Pro Lys Ile Ala Xaa Arg 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  116

Ala Thr His Xaa Pro Lys Ile Ala Xaa Arg 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  117

Ala Thr His Xaa Pro Lys Arg Ala Xaa Arg 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Arginine

<400>  118

Ala Thr His Xaa Pro Lys Ile Ala Xaa Arg 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine-Betaine

<400>  119

Ala Thr His Xaa Pro Lys Ile Ala Xaa Xaa 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_DMG_N_2ae_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  120

Ala Thr His Xaa Pro Lys Ile Ala Xaa Lys 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -(CH2)2CH=CH(CH2)2-trans linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  1PEG2_1PEG2_Dap_C18_Diacid conjugation

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D form Lysine

<400>  121

Ala Thr His Xaa Pro Lys Ile Ala Xaa Lys 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -CH2CH=CHCH2-cis  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is Lysine-carnitine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Butyl-Phenylalanine

<400>  122

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Xaa 
1               5                   10  


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Cyclic -CH2CH=CHCH2-trans  linkage to -Ala at 7

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is Lysine-carnitine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  123

Ala Thr His Xaa Pro Ala Ala Lys Xaa Lys Lys 
1               5                   10      


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -CH2CH=CHCH2-cis  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is Lysine-carnitine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is N-Methyl-Lysine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  N-Butyl-Phenylalanine

<400>  124

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Xaa 
1               5                   10  


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -CH2CH=CHCH2-cis  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is Lysine-carnitine

<400>  125

Ala Thr His Xaa Pro Ala Ile Ala Xaa Lys Xaa 
1               5                   10      


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -CH2CH=CHCH2-cis  linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is Lysine-carnitine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<400>  126

Ala Thr His Xaa Pro Ala Xaa Ala Xaa Lys 
1               5                   10  


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Cyclic -CH2CH=CHCH2-trans  linkage to -Ala at 7

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is NHCH2CH2N+(CH3)2CH2CO

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Ahx_Palm conjugation

<400>  127

Ala Thr His Xaa Pro Xaa Ala Xaa Lys 
1               5                   


<210>  128
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  Cyclic -CH2C(=CH2)C(=CH2)CH2 linkage to -Ala at 8

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is N-Methyl-Threonine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is beta,beta-diphenylalanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is beta-homophenylalanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Ahx_Palm conjugation

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D form lysine

<400>  128

Ala Xaa His Xaa Pro Ala Ile Ala Xaa Lys Lys 
1               5                   10      


<210>  129
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  129

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      


Ser Lys Cys Gly Met Cys Cys Lys Thr 
            20                  25  


<210>  130
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  130

Asp Thr His Phe Pro Ile Cys Ile Phe 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D form phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D form isoleucine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D form cysteine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D form isoleucine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D form proline

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D form phenylalanine

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D form histidine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D form threonine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D form aspartic acid

<400>  131

Phe Ile Cys Ile Pro Phe His Thr Asp 
1               5                   


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  2Peg11'-Palm conjugation

<400>  132

Asp Thr His Phe Pro Cys Ile Lys Phe Lys Pro Arg Ser Lys Gly Cys 
1               5                   10                  15      


Lys 
    


<210>  133
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Hepcidin Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Isovaleric acid conjugation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  2Peg11'-Palm conjugation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Sarcosine

<400>  133

Asp Thr His Phe Pro Cys Ile Lys Phe Lys Pro Arg Ser Lys Xaa Cys 
1               5                   10                  15      


Lys 
    


