                         SEQUENCE LISTING

<110>  Acerand Therapeutics (USA) Limited
 
<120>  PYRIDOPYRIMIDINONE COMPOUNDS

<130>  220007-0001PCT1

<150>  63/168,408
<151>  2021-03-31

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys 
                165                 


<210>  2
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Glu Gln Met Arg Leu Pro Ser Ala Asp Val Tyr Arg Phe Ala Glu 
1               5                   10                  15      


Pro Asp Ser Glu Glu Asn Ile Ile Phe Glu Glu Asn Met Gln Pro Lys 
            20                  25                  30          


Ala Gly Ile Pro Ile Ile Lys Ala Gly Thr Val Ile Lys Leu Ile Glu 
        35                  40                  45              


Arg Leu Thr Tyr His Met Tyr Ala Asp Pro Asn Phe Val Arg Thr Phe 
    50                  55                  60                  


Leu Thr Thr Tyr Arg Ser Phe Cys Lys Pro Gln Glu Leu Leu Ser Leu 
65                  70                  75                  80  


Ile Ile Glu Arg Phe Glu Ile Pro Glu Pro Glu Pro Thr Glu Ala Asp 
                85                  90                  95      


Arg Ile Ala Ile Glu Asn Gly Asp Gln Pro Leu Ser Ala Glu Leu Lys 
            100                 105                 110         


Arg Phe Arg Lys Glu Tyr Ile Gln Pro Val Gln Leu Arg Val Leu Asn 
        115                 120                 125             


Val Cys Arg His Trp Val Glu His His Phe Tyr Asp Phe Glu Arg Asp 
    130                 135                 140                 


Ala Tyr Leu Leu Gln Arg Met Glu Glu Phe Ile Gly Thr Val Arg Gly 
145                 150                 155                 160 


Lys Ala Met Lys Lys Trp Val Glu Ser Ile Thr Lys Ile Ile Gln Arg 
                165                 170                 175     


Lys Lys Ile Ala Arg Asp Asn Gly Pro Gly His Asn Ile Thr Phe Gln 
            180                 185                 190         


Ser Ser Pro Pro Thr Val Glu Trp His Ile Ser Arg Pro Gly His Ile 
        195                 200                 205             


Glu Thr Phe Asp Leu Leu Thr Leu His Pro Ile Glu Ile Ala Arg Gln 
    210                 215                 220                 


Leu Thr Leu Leu Glu Ser Asp Leu Tyr Arg Ala Val Gln Pro Ser Glu 
225                 230                 235                 240 


Leu Val Gly Ser Val Trp Thr Lys Glu Asp Lys Glu Ile Asn Ser Pro 
                245                 250                 255     


Asn Leu Leu Lys Met Ile Arg His Thr Thr Asn Leu Thr Leu Trp Phe 
            260                 265                 270         


Glu Lys Cys Ile Val Glu Thr Glu Asn Leu Glu Glu Arg Val Ala Val 
        275                 280                 285             


Val Ser Arg Ile Ile Glu Ile Leu Gln Val Phe Gln Glu Leu Asn Asn 
    290                 295                 300                 


Phe Asn Gly Val Leu Glu Val Val Ser Ala Met Asn Ser Ser Pro Val 
305                 310                 315                 320 


Tyr Arg Leu Asp His Thr Phe Glu Gln Ile Pro Ser Arg Gln Lys Lys 
                325                 330                 335     


Ile Leu Glu Glu Ala His Glu Leu Ser Glu Asp His Tyr Lys Lys Tyr 
            340                 345                 350         


Leu Ala Lys Leu Arg Ser Ile Asn Pro Pro Cys Val Pro Phe Phe Gly 
        355                 360                 365             


Ile Tyr Leu Thr Asn Ile Leu Lys Thr Glu Glu Gly Asn Pro Glu Val 
    370                 375                 380                 


Leu Lys Arg His Gly Lys Glu Leu Ile Asn Phe Ser Lys Arg Arg Lys 
385                 390                 395                 400 


Val Ala Glu Ile Thr Gly Glu Ile Gln Gln Tyr Gln Asn Gln Pro Tyr 
                405                 410                 415     


Cys Leu Arg Val Glu Ser Asp Ile Lys Arg Phe Phe Glu Asn Leu Asn 
            420                 425                 430         


Pro Met Gly Asn Ser Met Glu Lys Glu Phe Thr Asp Tyr Leu Phe Asn 
        435                 440                 445             


Lys Ser Leu Glu Ile Glu Pro Arg Asn Pro Lys Pro Leu Pro Arg Phe 
    450                 455                 460                 


Pro Lys Lys Tyr Ser Tyr Pro Leu Lys Ser Pro Gly Val Arg Pro Ser 
465                 470                 475                 480 


Asn Pro Arg Pro Gly Thr 
                485     


