                         SEQUENCE LISTING

<110>  University of Southern California
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING INFLAMMATORY AND 
       DEGENERATIVE DISORDER

<130>  00130-036WO1

<140>  Not yet assigned
<141>  2022-03-30

<150>  US 63/168,901
<151>  2021-03-31

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT peptide

<400>  1

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Penetratin peptide

<400>  2

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Buforin II peptide

<400>  3

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transportan peptide

<400>  4

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAP peptide

<400>  5

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K-FGF peptide

<400>  6

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ku70 peptide

<400>  7

Val Pro Met Leu Lys Pro Met Leu Lys Glu 
1               5                   10  


<210>  8
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Prion peptide

<400>  8

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pVEC peptide

<400>  9

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pep-1 peptide

<400>  10

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SynB1 peptide

<400>  11

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pep-7 peptide

<400>  12

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN-1 peptide

<400>  13

Thr Ser Pro Leu Asn Ile His Asn Gly Gln Lys Leu 
1               5                   10          


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa is an alpha-helix enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  Xaa is an alpha-helix enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is a basic amino acid

<400>  14

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any alpha helix enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Xaa is any basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  Xaa is any alpha helix enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any basic amino acid

<400>  15

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD sequence

<400>  16

Lys Lys Arg Pro Lys Pro Gly 
1               5           


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa is any alpha helical enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any alpha helical enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any alpha helical enhancing amino acid or a proline

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any alpha helical enhancing amino acid or basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is any basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any alpha helical enhancing amino acid or a proline

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any alpha helical enhancing amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is any basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is any alpha helical enhancing amino acid or basic amino acid

<400>  17

Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is R or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is R or K

<400>  18

Lys Xaa Arg Xaa Xaa 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  19

Gly Gly Gly Gly Ser 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  20

Gly Gly Gly Gly Ser 
1               5       


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  21

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  22

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  23

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Ser Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  24

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  25

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  26
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Thr 
        355                 360                 365             


Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala Thr 
    370                 375                 380                 


Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu Thr 
385                 390                 395                 400 


Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile Pro 
                405                 410                 415     


Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala Phe 
            420                 425                 430         


Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu Ser 
        435                 440                 445             


Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala Pro 
    450                 455                 460                 


Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr Tyr 
465                 470                 475                 480 


Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val Thr 
                485                 490                 495     


Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala Tyr 
            500                 505                 510         


Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys Lys 
        515                 520                 525             


Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val Asp 
    530                 535                 540                 


Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr Ile 
545                 550                 555                 560 


Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu Tyr 
                565                 570                 575     


Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met Ala 
            580                 585                 590         


Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr 
        595                 600                 605             


Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val 
    610                 615                 620                 


Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe 
625                 630                 635                 640 


Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
                645                 650                 655     


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            660                 665                 670         


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        675                 680                 685             


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    690                 695                 700                 


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
705                 710                 715                 720 


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                725                 730                 735     


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            740                 745                 750         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        755                 760                 765             


Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro 
    770                 775                 780                 


Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp His 
785                 790                 795                 800 


Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln 
                805                 810                 815     


Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu Arg 
            820                 825                 830         


Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu Lys 
        835                 840                 845             


Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln Met 
    850                 855                 860                 


Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly Thr 
865                 870                 875                 880 


Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala Thr 
                885                 890                 895     


Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            900                 905                 910         


Gly Tyr Met Pro Gln 
        915         


<210>  27
<211>  917
<212>  PRT
<213>  Mus Musculus

<400>  27

Met Ser Ala Pro Arg Ile Trp Leu Ala Gln Ala Leu Leu Phe Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Ile Gly Gln Leu Leu Glu Pro Cys Gly Tyr Ile Tyr 
            20                  25                  30          


Pro Glu Phe Pro Val Val Gln Arg Gly Ser Asn Phe Thr Ala Ile Cys 
        35                  40                  45              


Val Leu Lys Glu Ala Cys Leu Gln His Tyr Tyr Val Asn Ala Ser Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Ala Ala Val Pro Arg Glu Gln Val Thr 
65                  70                  75                  80  


Val Ile Asn Arg Thr Thr Ser Ser Val Thr Phe Thr Asp Val Val Leu 
                85                  90                  95      


Pro Ser Val Gln Leu Thr Cys Asn Ile Leu Ser Phe Gly Gln Ile Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Val Thr Met Leu Ser Gly Phe Pro Pro Asp Lys 
        115                 120                 125             


Pro Thr Asn Leu Thr Cys Ile Val Asn Glu Gly Lys Asn Met Leu Cys 
    130                 135                 140                 


Gln Trp Asp Pro Gly Arg Glu Thr Tyr Leu Glu Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr Glu Lys Phe Pro Asp Cys Gln Ser Lys His 
                165                 170                 175     


Gly Thr Ser Cys Met Val Ser Tyr Met Pro Thr Tyr Tyr Val Asn Ile 
            180                 185                 190         


Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Ser Ser Glu 
        195                 200                 205             


Ser Ile Asn Phe Asp Pro Val Asp Lys Val Lys Pro Thr Pro Pro Tyr 
    210                 215                 220                 


Asn Leu Ser Val Thr Asn Ser Glu Glu Leu Ser Ser Ile Leu Lys Leu 
225                 230                 235                 240 


Ser Trp Val Ser Ser Gly Leu Gly Gly Leu Leu Asp Leu Lys Ser Asp 
                245                 250                 255     


Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ile Gln Val Pro Leu 
            260                 265                 270         


Glu Asp Thr Met Ser Pro Arg Thr Ser Phe Thr Val Gln Asp Leu Lys 
        275                 280                 285             


Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Ser Ile Lys Asp Ser Gly 
    290                 295                 300                 


Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Thr Thr Tyr 
305                 310                 315                 320 


Glu Asp Arg Pro Ser Arg Pro Pro Ser Phe Trp Tyr Lys Thr Asn Pro 
                325                 330                 335     


Ser His Gly Gln Glu Tyr Arg Ser Val Arg Leu Ile Trp Lys Ala Leu 
            340                 345                 350         


Pro Leu Ser Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val Ile Leu 
        355                 360                 365             


Thr Gln Ser Lys Ser Val Ser Gln Thr Tyr Thr Val Thr Gly Thr Glu 
    370                 375                 380                 


Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Val Ala Ser Leu Ala Ala 
385                 390                 395                 400 


Arg Asn Lys Val Gly Lys Ser Ala Ala Ala Val Leu Thr Ile Pro Ser 
                405                 410                 415     


Pro His Val Thr Ala Ala Tyr Ser Val Val Asn Leu Lys Ala Phe Pro 
            420                 425                 430         


Lys Asp Asn Leu Leu Trp Val Glu Trp Thr Pro Pro Pro Lys Pro Val 
        435                 440                 445             


Ser Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Glu Asn Ala Pro Cys 
    450                 455                 460                 


Val Glu Asp Trp Gln Gln Glu Asp Ala Thr Val Asn Arg Thr His Leu 
465                 470                 475                 480 


Arg Gly Arg Leu Leu Glu Ser Lys Cys Tyr Gln Ile Thr Val Thr Pro 
                485                 490                 495     


Val Phe Ala Thr Gly Pro Gly Gly Ser Glu Ser Leu Lys Ala Tyr Leu 
            500                 505                 510         


Lys Gln Ala Ala Pro Ala Arg Gly Pro Thr Val Arg Thr Lys Lys Val 
        515                 520                 525             


Gly Lys Asn Glu Ala Val Leu Ala Trp Asp Gln Ile Pro Val Asp Asp 
    530                 535                 540                 


Gln Asn Gly Phe Ile Arg Asn Tyr Ser Ile Ser Tyr Arg Thr Ser Val 
545                 550                 555                 560 


Gly Lys Glu Met Val Val His Val Asp Ser Ser His Thr Glu Tyr Thr 
                565                 570                 575     


Leu Ser Ser Leu Ser Ser Asp Thr Leu Tyr Met Val Arg Met Ala Ala 
            580                 585                 590         


Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe Thr Thr 
        595                 600                 605             


Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro Val Cys 
    610                 615                 620                 


Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys Phe Asn 
625                 630                 635                 640 


Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp Pro 
                645                 650                 655     


Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg His 
            660                 665                 670         


Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr Asp 
        675                 680                 685             


Val Ser Val Val Glu Ile Glu Ala Asn Asn Lys Lys Pro Cys Pro Asp 
    690                 695                 700                 


Asp Leu Lys Ser Val Asp Leu Phe Lys Lys Glu Lys Val Ser Thr Glu 
705                 710                 715                 720 


Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser Arg 
                725                 730                 735     


Pro Ser Ile Ser Ser Asn Glu Glu Asn Glu Ser Ala Gln Ser Thr Ala 
            740                 745                 750         


Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His Gln 
        755                 760                 765             


Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln Pro Leu 
    770                 775                 780                 


Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp Ser Val 
785                 790                 795                 800 


Asp Gly Gly Asp Glu Ile Leu Pro Arg Gln Pro Tyr Phe Lys Gln Asn 
                805                 810                 815     


Cys Ser Gln Pro Glu Ala Cys Pro Glu Ile Ser His Phe Glu Arg Ser 
            820                 825                 830         


Asn Gln Val Leu Ser Gly Asn Glu Glu Asp Phe Val Arg Leu Lys Gln 
        835                 840                 845             


Gln Gln Val Ser Asp His Ile Ser Gln Pro Tyr Gly Ser Glu Gln Arg 
    850                 855                 860                 


Arg Leu Phe Gln Glu Gly Ser Thr Ala Asp Ala Leu Gly Thr Gly Ala 
865                 870                 875                 880 


Asp Gly Gln Met Glu Arg Phe Glu Ser Val Gly Met Glu Thr Thr Ile 
                885                 890                 895     


Asp Glu Glu Ile Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln Gly 
            900                 905                 910         


Gly Tyr Met Pro Gln 
        915         


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP forward primer

<400>  28
gatggacgtt cggtttagg                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP reverse primer

<400>  29
agcagcacag tacgagcaa                                                    19


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP13 forward primer

<400>  30
actgagaggc tccgagaaat g                                                 21


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MMP13 reverse primer

<400>  31
gaaccccgca tcttggctt                                                    19


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADAMTS5 forward primer

<400>  32
gaacatcgac caactctact ccg                                               23


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADAMTS5 reverse primer

<400>  33
caatgcccac cgaaccatct                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADAMTS4 forward primer

<400>  34
gcaacgtcaa ggctcctctt                                                   20


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADAMTS4 reverse primer

<400>  35
ctccacaaat ctactcagtg aagca                                             25


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Collagen II forward primer

<400>  36
cctggcaaag atggtgagac ag                                                22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Collagen II reverse primer

<400>  37
cctggttttc caccttcacc tg                                                22


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aggrecan forward primer

<400>  38
aggcagcgtg atccttacc                                                    19


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Aggrecan reverse primer

<400>  39
ggcctctcca gtctcattct c                                                 21


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
gatggtattt tgcccaggag tcagcatgaa tccagt                                 36


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  41

Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  42

Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser 
1               5                   10                  15  


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser 
1               5                   10                  15      


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro 
1               5                   10                  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
1               5                   10                  15  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  47

Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
1               5                   10                  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  48

Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp 
1               5                   10                  15  


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  49

Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn 
1               5                   10                  15      


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  50

Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  51

Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  52

Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln 
1               5                   10                  15  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  53

Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu 
1               5                   10                  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  54

Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser 
1               5                   10                  15  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  55

Gln Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu 
1               5                   10          


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  56

Gln Gln Tyr Phe Lys 
1               5   


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 sgRNA

<400>  57
aaaatgtgaa atctctggac agg                                               23


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Y at position 5 is phosphorylated or not phosphorylated

<400>  58

Pro Arg Gln Pro Tyr Phe Lys Gln Asn Cys 
1               5                   10  


<210>  59
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide fragment

<400>  59
atgagatctt gcccaggcaa ccgtatttca agcagaactg cagtcagcct                  50


<210>  60
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide fragment

<400>  60
atgagatctt gcccaggcaa ccgtttttca agcagaactg cagtcagcct g                51


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  61

Ile Leu Pro Arg Gln Gln Tyr Phe 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  62

Gln Tyr Phe Lys Gln Asn Cys Ser 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  63

Leu Pro Arg Gln Gln Tyr Phe Lys 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  64

Arg Gln Gln Tyr Phe Lys Gln Asn 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  65

Pro Arg Gln Gln Tyr Phe Lys Gln 
1               5               


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  66

His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe 
1               5                   10                  15  


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  67

Gln Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Glu Ser Ser Pro Asp 
1               5                   10                  15      


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  68

Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys Gln Asn Cys Ser 
1               5                   10                  


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  69

Gly Ile Leu Pro Arg Gln Gln Tyr 
1               5               


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  70

Phe Lys Gln Asn Cys Ser 
1               5       


<210>  71
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  71

His Trp Trp Tyr Ile Thr Thr Gly Pro Val Arg Glu Lys 
1               5                   10              


