                               SEQUENCE LISTING

<110> MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120> ANTIGEN RECOGNIZING RECEPTORS TARGETING GD3 GANGLIOSIDE AND USES 
      THEREOF

<130> 072734.1332

<140>
<141>

<150> 63/214,212
<151> 2021-06-23

<150> 63/168,543
<151> 2021-03-31

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Asn Phe Gly Met His 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Tyr Ile Thr Ser Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Arg Ala Ser Gln Asp Ile Gly Asn Phe Leu Asn 
1               5                   10      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Tyr Thr Ser Arg Leu Gln Ser 
1               5           


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gln Gln Gly Lys Thr Leu Pro Tyr Thr 
1               5                   


<210> 7
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 8
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Arg Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp 
            100                 105             


<210> 9
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Ser Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Arg Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Asp Ile Gly Asn Phe Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Gly Lys Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Asp 
                245 


<210> 10
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Arg Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Asp Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe Gly Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Thr Ser 
                165                 170                 175     


Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Gly Gly Thr 
    210                 215                 220                 


Gly Thr Arg Ser Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210> 11
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcagaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc aacttcggca tgcactgggt gagacaggcc      120

cccggcaagg gcctggagtg ggtggcctac atcaccagcg gcggcagcag catcaactac      180

gccgacaccg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcac cagaggcggc      300

accggcacca gaagcctgta ctacttcgac tactggggcc agggcaccac cgtgaccgtg      360

agcagcggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacatccag      420

atgacccaga gccccagaag cctgagcgcc agcgtgggcg acagagtgac catcacctgc      480

agagccagcc aggacatcgg caacttcctg aactggtacc aacagaagcc cggcaaggcc      540

cccaagctgc tgatctacta caccagtaga ctgcagagcg gcgtgcccag cagatttagt      600

ggtagcggta gcggcaccga ctacaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gggcaagacc ctgccctaca ccttcggcgg cggcaccaag      720

gtggagatca aggac                                                       735


<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Tyr Ile Ser Ser Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val 
1               5                   10                  15  


<210> 13
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 14
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 15
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Ser Ser Ile Asn Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Thr Leu Ile Val Ser Ser 
        115                 120         


<210> 16
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 17
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 19
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210> 20
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Gly Gly Gly Ser 
1               5   


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 23
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210> 24
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Met 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Val Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Pro 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210> 25
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 26
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210> 27
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210> 28
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc       60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc         117


<210> 29
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210> 30
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 31
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210> 32
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
1               5                   10                  15      


Asp Val Leu Asp Lys Arg 
            20          


<210> 33
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac       60

aagaga                                                                  66


<210> 34
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
1               5                   10                  15      


Asp Val Leu Asp Lys Arg 
            20          


<210> 35
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
cagaaccagc tctttaacga gctcaatcta ggacgaagag aggagttcga tgttttggac       60

aagaga                                                                  66


<210> 36
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
1               5                   10                  15      


Tyr Ser Glu Ile Gly Met Lys 
            20              


<210> 37
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt       60

gggatgaaa                                                               69


<210> 38
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
1               5                   10                  15      


Phe Ser Glu Ile Gly Met Lys 
            20              


<210> 39
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
caggaaggcc tgttcaatga actgcagaaa gataagatgg cggaggcctt cagtgagatt       60

gggatgaaa                                                               69


<210> 40
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
1               5                   10                  15      


Asp Ala Leu His Met Gln 
            20          


<210> 41
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac       60

atgcag                                                                  66


<210> 42
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
1               5                   10                  15      


Asp Ala Leu His Met Gln 
            20          


<210> 43
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
cacgatggcc ttttccaggg gctcagtaca gccaccaagg acaccttcga cgcccttcac       60

atgcag                                                                  66


<210> 44
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 45
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc caggggctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210> 46
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210> 47
<211> 255
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210> 48
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 48
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210> 49
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Thr Ser Gly Gly Ser Ser Ile Asn Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Arg Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Phe Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser 
        195                 200                 205             


Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Ala Ala Ile Glu Val Met 
            260                 265                 270         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
        275                 280                 285             


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
    290                 295                 300                 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210> 50
<211> 1467
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 50
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgctgaacag       60

gtgcagctgg tggagagcgg cggcggcgtg gtgcagcccg gcagaagcct gagactgagc      120

tgcgccgcca gcggcttcac cttcagcaac ttcggcatgc actgggtgag acaggccccc      180

ggcaagggcc tggagtgggt ggcctacatc accagcggcg gcagcagcat caactacgcc      240

gacaccgtga agggcagatt caccatcagc agagacaaca gcaagaacac cctgtacctg      300

cagatgaaca gcctgagagc cgaggacacc gccgtgtact actgcaccag aggcggcacc      360

ggcaccagaa gcctgtacta cttcgactac tggggccagg gcaccaccgt gaccgtgagc      420

agcggtggag gtggatcagg tggaggtgga tctggtggag gtggatctga catccagatg      480

acccagagcc ccagaagcct gagcgccagc gtgggcgaca gagtgaccat cacctgcaga      540

gccagccagg acatcggcaa cttcctgaac tggtaccaac agaagcccgg caaggccccc      600

aagctgctga tctactacac cagtagactg cagagcggcg tgcccagcag atttagtggt      660

agcggtagcg gcaccgacta caccctgacc atcagcagcc tgcagcccga ggacttcgcc      720

acctactact gccagcaggg caagaccctg ccctacacct tcggcggcgg caccaaggtg      780

gagatcaagg acgcggccgc ggccgcaatt gaagttatgt atcctcctcc ttacctagac      840

aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg tccaagtccc      900

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      960

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1020

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1080

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1140

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1200

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1260

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1320

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1380

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1440

cacatgcagg ccctgccccc tcgctaa                                         1467


<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 52
<211> 496
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Thr Ser Gly Gly Ser Ser Ile Asn Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Gly Thr Gly Thr Arg Ser Leu Tyr Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Arg Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Phe Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr Ser 
        195                 200                 205             


Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Asp Asp Tyr Lys Asp Asp Asp Asp Lys 
            260                 265                 270         


Ala Ala Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            340                 345                 350         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        355                 360                 365             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210> 53
<211> 1491
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 53
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgctgaacag       60

gtgcagctgg tggagagcgg cggcggcgtg gtgcagcccg gcagaagcct gagactgagc      120

tgcgccgcca gcggcttcac cttcagcaac ttcggcatgc actgggtgag acaggccccc      180

ggcaagggcc tggagtgggt ggcctacatc accagcggcg gcagcagcat caactacgcc      240

gacaccgtga agggcagatt caccatcagc agagacaaca gcaagaacac cctgtacctg      300

cagatgaaca gcctgagagc cgaggacacc gccgtgtact actgcaccag aggcggcacc      360

ggcaccagaa gcctgtacta cttcgactac tggggccagg gcaccaccgt gaccgtgagc      420

agcggtggag gtggatcagg tggaggtgga tctggtggag gtggatctga catccagatg      480

acccagagcc ccagaagcct gagcgccagc gtgggcgaca gagtgaccat cacctgcaga      540

gccagccagg acatcggcaa cttcctgaac tggtaccaac agaagcccgg caaggccccc      600

aagctgctga tctactacac cagtagactg cagagcggcg tgcccagcag atttagtggt      660

agcggtagcg gcaccgacta caccctgacc atcagcagcc tgcagcccga ggacttcgcc      720

acctactact gccagcaggg caagaccctg ccctacacct tcggcggcgg caccaaggtg      780

gagatcaagg acgactacaa agacgatgac gacaaggcgg ccgcggccgc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1080

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1140

gcctatcgct ccagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1200

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1260

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1320

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1380

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1440

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta a              1491


<210> 54
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile Arg Asn Leu Asn 
1               5                   10                  15      


Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro Leu Phe Glu Asp 
            20                  25                  30          


Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg Thr Ile Phe Ile 
        35                  40                  45              


Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met Ala Val Thr Ile 
    50                  55                  60                  


Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys Glu Asn Lys Ile 
65                  70                  75                  80  


Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile Lys Asp Thr Lys 
                85                  90                  95      


Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly His Asp Asn Lys 
            100                 105                 110         


Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe Leu Ala Cys Glu 
        115                 120                 125             


Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys Glu Asp Glu Leu 
    130                 135                 140                 


Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu Asp 
145                 150                 155         


<210> 55
<211> 471
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 55
tacttcggca agctggagag caagctgagc gtgatcagga acctgaacga ccaggtgctg       60

ttcatcgacc agggcaacag gcccctgttc gaggacatga ccgacagcga ctgcagggac      120

aacgccccca ggaccatctt catcatcagc atgtacaagg acagccagcc caggggcatg      180

gccgtgacca tcagcgtgaa gtgcgagaag atcagcaccc tgagctgcga gaacaagatc      240

atcagcttca aggagatgaa cccccccgac aacatcaagg acaccaagag cgacatcatc      300

ttcttccaga ggagcgtgcc cggccacgac aacaagatgc agttcgagag cagcagctac      360

gagggctact tcctggcctg cgagaaggag agggacctgt tcaagctgat cctgaagaag      420

gaggacgagc tgggcgacag gagcatcatg ttcaccgtgc agaacgagga c               471


<210> 56
<211> 153
<212> PRT
<213> Homo sapiens

<400> 56
Lys Ile Asp Thr Pro Gln Gln Gly Ser Ile Gln Asp Ile Asn His Arg 
1               5                   10                  15      


Val Trp Val Leu Gln Asp Gln Thr Leu Ile Ala Val Pro Arg Lys Asp 
            20                  25                  30          


Arg Met Ser Pro Val Thr Ile Ala Leu Ile Ser Cys Arg His Val Glu 
        35                  40                  45              


Thr Leu Glu Lys Asp Arg Gly Asn Pro Ile Tyr Leu Gly Leu Asn Gly 
    50                  55                  60                  


Leu Asn Leu Cys Leu Met Cys Ala Lys Val Gly Asp Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Lys Asp Ile Met Asp Leu Tyr Asn Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Ser Phe Leu Phe Tyr His Ser Gln Ser Gly Arg Asn Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly Trp Phe Ile Ala Val Ser Ser Glu 
        115                 120                 125             


Gly Gly Cys Pro Leu Ile Leu Thr Gln Glu Leu Gly Lys Ala Asn Thr 
    130                 135                 140                 


Thr Asp Phe Gly Leu Thr Met Leu Phe 
145                 150             


<210> 57
<211> 160
<212> PRT
<213> Homo sapiens

<400> 57
Arg Glu Ala Ala Pro Lys Ser Tyr Ala Ile Arg Asp Ser Arg Gln Met 
1               5                   10                  15      


Val Trp Val Leu Ser Gly Asn Ser Leu Ile Ala Ala Pro Leu Ser Arg 
            20                  25                  30          


Ser Ile Lys Pro Val Thr Leu His Leu Ile Ala Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Ser Asp Lys Glu Lys Gly Asn Met Val Tyr Leu Gly Ile Lys Gly 
    50                  55                  60                  


Lys Asp Leu Cys Leu Phe Cys Ala Glu Ile Gln Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Leu Gln Gly Ser Gln Asp Asn Ile Gly Lys Asp Thr Cys 
                85                  90                  95      


Trp Lys Leu Val Gly Ile His Thr Cys Ile Asn Leu Asp Val Arg Glu 
            100                 105                 110         


Ser Cys Phe Met Gly Thr Leu Asp Gln Trp Gly Ile Gly Val Gly Arg 
        115                 120                 125             


Lys Lys Trp Lys Ser Ser Phe Gln His His His Leu Arg Lys Lys Asp 
    130                 135                 140                 


Lys Asp Phe Ser Ser Met Arg Thr Asn Ile Gly Met Pro Gly Arg Met 
145                 150                 155                 160 


<210> 58
<211> 152
<212> PRT
<213> Homo sapiens

<400> 58
Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp Leu Asn Gln Gln 
1               5                   10                  15      


Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val Pro Arg Ser Asp 
            20                  25                  30          


Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu Gln Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly Gln Pro Glu Pro 
                85                  90                  95      


Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly Arg Thr Ser Thr 
            100                 105                 110         


Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala Ser Ser Lys Arg 
        115                 120                 125             


Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys Ser Tyr Asn Thr 
    130                 135                 140                 


Ala Phe Glu Leu Asn Ile Asn Asp 
145                 150         


<210> 59
<211> 152
<212> PRT
<213> Mus musculus

<400> 59
Gly Arg Glu Thr Pro Asp Phe Gly Glu Val Phe Asp Leu Asp Gln Gln 
1               5                   10                  15      


Val Trp Ile Phe Arg Asn Gln Ala Leu Val Thr Val Pro Arg Ser His 
            20                  25                  30          


Arg Val Thr Pro Val Ser Val Thr Ile Leu Pro Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ser Leu Glu Gln Asp Lys Gly Ile Ala Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Asp Lys Cys Leu Phe Cys Lys Glu Val Asn Gly His Pro Thr Leu 
65                  70                  75                  80  


Leu Leu Lys Glu Glu Lys Ile Leu Asp Leu Tyr His His Pro Glu Pro 
                85                  90                  95      


Met Lys Pro Phe Leu Phe Tyr His Thr Arg Thr Gly Gly Thr Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly His Tyr Ile Ala Ser Ser Lys Thr 
        115                 120                 125             


Gly Asn Pro Ile Phe Leu Thr Ser Lys Lys Gly Glu Tyr Tyr Asn Ile 
    130                 135                 140                 


Asn Phe Asn Leu Asp Ile Lys Ser 
145                 150         


<210> 60
<211> 153
<212> PRT
<213> Mus musculus

<400> 60
Ser Ser Gln Ser Pro Arg Asn Tyr Arg Val His Asp Ser Gln Gln Met 
1               5                   10                  15      


Val Trp Val Leu Thr Gly Asn Thr Leu Thr Ala Val Pro Ala Ser Asn 
            20                  25                  30          


Asn Val Lys Pro Val Ile Leu Ser Leu Ile Ala Cys Arg Asp Thr Glu 
        35                  40                  45              


Phe Gln Asp Val Lys Lys Gly Asn Leu Val Phe Leu Gly Ile Lys Asn 
    50                  55                  60                  


Arg Asn Leu Cys Phe Cys Cys Val Glu Met Glu Gly Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Lys Glu Val Asp Ile Met Asn Leu Tyr Lys Glu Arg Lys Ala 
                85                  90                  95      


Gln Lys Ala Phe Leu Phe Tyr His Gly Ile Glu Gly Ser Thr Ser Val 
            100                 105                 110         


Phe Gln Ser Val Leu Tyr Pro Gly Trp Phe Ile Ala Thr Ser Ser Ile 
        115                 120                 125             


Glu Arg Gln Thr Ile Ile Leu Thr His Gln Arg Gly Lys Leu Val Asn 
    130                 135                 140                 


Thr Asn Phe Tyr Ile Glu Ser Glu Lys 
145                 150             


<210> 61
<211> 152
<212> PRT
<213> Mus musculus

<400> 61
Gly Arg Glu Thr Pro Asp Phe Gly Glu Val Phe Asp Leu Asp Gln Gln 
1               5                   10                  15      


Val Trp Ile Phe Arg Asn Gln Ala Leu Val Thr Val Pro Arg Ser His 
            20                  25                  30          


Arg Val Thr Pro Val Ser Val Thr Ile Leu Pro Cys Lys Tyr Pro Glu 
        35                  40                  45              


Ser Leu Glu Gln Asp Lys Gly Ile Ala Ile Tyr Leu Gly Ile Gln Asn 
    50                  55                  60                  


Pro Asp Lys Cys Leu Phe Cys Lys Glu Val Asn Gly His Pro Thr Leu 
65                  70                  75                  80  


Leu Leu Lys Glu Glu Lys Ile Leu Asp Leu Tyr His His Pro Glu Pro 
                85                  90                  95      


Met Lys Pro Phe Leu Phe Tyr His Thr Arg Thr Gly Gly Thr Ser Thr 
            100                 105                 110         


Phe Glu Ser Val Ala Phe Pro Gly His Tyr Ile Ala Ser Ser Lys Thr 
        115                 120                 125             


Gly Asn Pro Ile Phe Leu Thr Ser Lys Lys Gly Glu Tyr Tyr Asn Ile 
    130                 135                 140                 


Asn Phe Asn Leu Asp Ile Lys Ser 
145                 150         


<210> 62
<211> 159
<212> PRT
<213> Homo sapiens

<400> 62
Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser 
1               5                   10                  15      


Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr 
            20                  25                  30          


Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val 
        35                  40                  45              


Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp 
    50                  55                  60                  


Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp 
65                  70                  75                  80  


Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys 
                85                  90                  95      


Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met 
            100                 105                 110         


His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe 
        115                 120                 125             


Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser 
    130                 135                 140                 


Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
145                 150                 155                 


<210> 63
<211> 158
<212> PRT
<213> Mus musculus

<400> 63
Ser Ile Gln Gly Thr Ser Leu Leu Thr Gln Ser Pro Ala Ser Leu Ser 
1               5                   10                  15      


Thr Tyr Asn Asp Gln Ser Val Ser Phe Val Leu Glu Asn Gly Cys Tyr 
            20                  25                  30          


Val Ile Asn Val Asp Asp Ser Gly Lys Asp Gln Glu Gln Asp Gln Val 
        35                  40                  45              


Leu Leu Arg Tyr Tyr Glu Ser Pro Cys Pro Ala Ser Gln Ser Gly Asp 
    50                  55                  60                  


Gly Val Asp Gly Lys Lys Leu Met Val Asn Met Ser Pro Ile Lys Asp 
65                  70                  75                  80  


Thr Asp Ile Trp Leu His Ala Asn Asp Lys Asp Tyr Ser Val Glu Leu 
                85                  90                  95      


Gln Arg Gly Asp Val Ser Pro Pro Glu Gln Ala Phe Phe Val Leu His 
            100                 105                 110         


Lys Lys Ser Ser Asp Phe Val Ser Phe Glu Cys Lys Asn Leu Pro Gly 
        115                 120                 125             


Thr Tyr Ile Gly Val Lys Asp Asn Gln Leu Ala Leu Val Glu Glu Lys 
    130                 135                 140                 


Asp Glu Ser Cys Asn Asn Ile Met Phe Lys Leu Ser Lys Ile 
145                 150                 155             


