<110>    Korea University Research and Business Foundation

<120>    Recombinant microalga with highly improved tolerances towards
         high CO2 and/or low pH conditions

<130>    JKPCT199

<150>    KR 10-2021-0042862
<151>    2021-04-01

<160>    4

<170>    KoPatentIn 3.0

<210>    1
<211>    952
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of PMA4


<400>    1
Met Ala Lys Ala Ile Ser Leu Glu Glu Ile Lys Asn Glu Thr Val Asp
  1               5                  10                  15 

Leu Glu Lys Ile Pro Ile Glu Glu Val Phe Glu Gln Leu Lys Cys Thr
             20                  25                  30 

Arg Glu Gly Leu Ser Ala Asp Glu Gly Ala Ser Arg Leu Gln Ile Phe
         35                  40                  45 

Gly Pro Asn Lys Leu Glu Glu Lys Asn Glu Ser Lys Ile Leu Lys Phe
     50                  55                  60 

Leu Gly Phe Met Trp Asn Pro Leu Ser Trp Val Met Glu Ala Ala Ala
 65                  70                  75                  80 

Val Met Ala Ile Ala Leu Ala Asn Gly Asp Gly Lys Pro Pro Asp Trp
                 85                  90                  95 

Gln Asp Phe Ile Gly Ile Ile Cys Leu Leu Val Ile Asn Ser Thr Ile
            100                 105                 110 

Ser Phe Ile Glu Glu Asn Asn Ala Gly Asn Ala Ala Ala Ala Leu Met
        115                 120                 125 

Ala Gly Leu Ala Pro Lys Thr Lys Val Leu Arg Asp Gly Arg Trp Ser
    130                 135                 140 

Glu Gln Glu Ala Ala Ile Leu Val Pro Gly Asp Ile Ile Ser Val Lys
145                 150                 155                 160 

Leu Gly Asp Ile Ile Pro Ala Asp Ala Arg Leu Leu Glu Gly Asp Pro
                165                 170                 175 

Leu Lys Ile Asp Gln Ser Ala Leu Thr Gly Glu Ser Leu Pro Val Thr
            180                 185                 190 

Lys Asn Pro Gly Asp Glu Val Phe Ser Gly Ser Thr Cys Lys Gln Gly
        195                 200                 205 

Glu Leu Glu Ala Val Val Ile Ala Thr Gly Val His Thr Phe Phe Gly
    210                 215                 220 

Lys Ala Ala His Leu Val Asp Ser Thr Asn Asn Val Gly His Phe Gln
225                 230                 235                 240 

Lys Val Leu Thr Ala Ile Gly Asn Phe Cys Ile Cys Ser Ile Ala Ile
                245                 250                 255 

Gly Met Leu Val Glu Ile Ile Val Met Tyr Pro Ile Gln His Arg Lys
            260                 265                 270 

Tyr Arg Asp Gly Ile Asp Asn Leu Leu Val Leu Leu Ile Gly Gly Ile
        275                 280                 285 

Pro Ile Ala Met Pro Thr Val Leu Ser Val Thr Met Ala Ile Gly Ser
    290                 295                 300 

His Arg Leu Ser Gln Gln Gly Ala Ile Thr Lys Arg Met Thr Ala Ile
305                 310                 315                 320 

Glu Glu Met Ala Gly Met Asp Val Leu Cys Ser Asp Lys Thr Gly Thr
                325                 330                 335 

Leu Thr Leu Asn Lys Leu Ser Val Asp Arg Asn Leu Val Glu Val Phe
            340                 345                 350 

Ala Lys Gly Val Asp Lys Glu Tyr Val Leu Leu Leu Ala Ala Arg Ala
        355                 360                 365 

Ser Arg Val Glu Asn Gln Asp Ala Ile Asp Ala Cys Met Val Gly Met
    370                 375                 380 

Leu Ala Asp Pro Lys Glu Ala Arg Ala Gly Ile Arg Glu Val His Phe
385                 390                 395                 400 

Leu Pro Phe Asn Pro Val Asp Lys Arg Thr Ala Leu Thr Tyr Ile Asp
                405                 410                 415 

Asn Asn Asn Asn Trp His Arg Ala Ser Lys Gly Ala Pro Glu Gln Ile
            420                 425                 430 

Leu Asp Leu Cys Asn Ala Lys Glu Asp Val Arg Arg Lys Val His Ser
        435                 440                 445 

Met Met Asp Lys Tyr Ala Glu Arg Gly Leu Arg Ser Leu Ala Val Ala
    450                 455                 460 

Arg Arg Thr Val Pro Glu Lys Ser Lys Glu Ser Pro Gly Gly Arg Trp
465                 470                 475                 480 

Glu Phe Val Gly Leu Leu Pro Leu Phe Asp Pro Pro Arg His Asp Ser
                485                 490                 495 

Ala Glu Thr Ile Arg Arg Ala Leu Asn Leu Gly Val Asn Val Lys Met
            500                 505                 510 

Ile Thr Gly Asp Gln Leu Ala Ile Ala Lys Glu Thr Gly Arg Arg Leu
        515                 520                 525 

Gly Met Gly Thr Asn Met Tyr Pro Ser Ala Ser Leu Leu Gly Gln Asp
    530                 535                 540 

Lys Asp Ser Ala Ile Ala Ser Leu Pro Ile Glu Glu Leu Ile Glu Lys
545                 550                 555                 560 

Ala Asp Gly Phe Ala Gly Val Phe Pro Glu His Lys Tyr Glu Ile Val
                565                 570                 575 

Lys Lys Leu Gln Glu Arg Lys His Ile Val Gly Met Thr Gly Asp Gly
            580                 585                 590 

Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Val
        595                 600                 605 

Ala Asp Ala Thr Asp Ala Ala Arg Gly Ala Ser Asp Ile Val Leu Thr
    610                 615                 620 

Glu Pro Gly Leu Ser Val Ile Ile Ser Ala Val Leu Thr Ser Arg Ala
625                 630                 635                 640 

Ile Phe Gln Arg Met Lys Asn Tyr Thr Ile Tyr Ala Val Ser Ile Thr
                645                 650                 655 

Ile Arg Ile Val Phe Gly Phe Met Phe Ile Ala Leu Ile Trp Lys Tyr
            660                 665                 670 

Asp Phe Ser Ala Phe Met Val Leu Ile Ile Ala Ile Leu Asn Asp Gly
        675                 680                 685 

Thr Ile Met Thr Ile Ser Lys Asp Arg Val Lys Pro Ser Pro Met Pro
    690                 695                 700 

Asp Ser Trp Lys Leu Lys Glu Ile Phe Ala Thr Gly Val Val Leu Gly
705                 710                 715                 720 

Gly Tyr Gln Ala Leu Met Thr Val Val Phe Phe Trp Ala Met His Asp
                725                 730                 735 

Thr Asp Phe Phe Ser Asp Lys Phe Gly Val Lys Ser Leu Arg Asn Ser
            740                 745                 750 

Asp Glu Glu Met Met Ser Ala Leu Tyr Leu Gln Val Ser Ile Ile Ser
        755                 760                 765 

Gln Ala Leu Ile Phe Val Thr Arg Ser Arg Ser Trp Ser Phe Leu Glu
    770                 775                 780 

Arg Pro Gly Met Leu Leu Val Ile Ala Phe Met Ile Ala Gln Leu Val
785                 790                 795                 800 

Ala Thr Leu Ile Ala Val Tyr Ala Asn Trp Ala Phe Ala Arg Val Lys
                805                 810                 815 

Gly Cys Gly Trp Gly Trp Ala Gly Val Ile Trp Leu Tyr Ser Ile Ile
            820                 825                 830 

Phe Tyr Leu Pro Leu Asp Ile Met Lys Phe Ala Ile Arg Tyr Ile Leu
        835                 840                 845 

Ser Gly Lys Ala Trp Asn Asn Leu Leu Asp Asn Lys Thr Ala Phe Thr
    850                 855                 860 

Thr Lys Lys Asp Tyr Gly Lys Glu Glu Arg Glu Ala Gln Trp Ala Leu
865                 870                 875                 880 

Ala Gln Arg Thr Leu His Gly Leu Gln Pro Pro Glu Ala Thr Asn Leu
                885                 890                 895 

Phe Asn Glu Lys Asn Ser Tyr Arg Glu Leu Ser Glu Ile Ala Glu Gln
            900                 905                 910 

Ala Lys Arg Arg Ala Glu Met Ala Arg Leu Arg Glu Leu His Thr Leu
        915                 920                 925 

Lys Gly His Val Glu Ser Val Val Lys Leu Lys Gly Leu Asp Ile Glu
    930                 935                 940 

Thr Ile Gln Gln His Tyr Thr Val
945                 950        


<210>    2
<211>    2856
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    polynucleotide sequence of PMA4


<400>    2
atggccaagg ccatcagcct ggaggagatc aagaacgaga ccgtggacct ggagaagatc         60

cccatcgagg aggtgttcga gcagctgaag tgcacccgcg agggcctgag cgctgacgag        120

ggcgctagcc gcctgcagat tttcggcccc aacaagctgg aggagaagaa cgagagcaag        180

atcctgaagt tcctgggctt catgtggaac ccgctgagct gggtcatgga ggctgctgcc        240

gtgatggcta tcgctctggc taacggcgac ggcaagccgc cggactggca ggacttcatc        300

ggcatcattt gcctgctggt catcaacagc accatcagct tcattgagga gaacaacgcc        360

ggcaacgccg ctgccgctct gatggctggc ctggctccca agaccaaggt gctgcgcgac        420

ggccggtgga gcgagcagga ggccgctatt ctggtccccg gcgacatcat tagcgtgaag        480

ctgggcgaca ttatccccgc tgacgctcgc ctgctggagg gcgacccgct gaagattgac        540

cagtccgctc tgaccggcga gtcgctgccc gtgacgaaga acccgggcga cgaggtgttc        600

agcggctcga cctgcaagca gggcgagctg gaggctgtgg tcattgctac cggcgtgcac        660

accttcttcg gcaaggctgc tcacctggtg gacagcacca acaacgtggg ccacttccag        720

aaggtgctga ccgcgattgg caacttctgc atctgctcga tcgccatcgg catgctggtc        780

gagatcatcg tgatgtaccc catccagcac cgcaagtacc gcgacggcat tgacaacctg        840

ctggtgctgc tgattggcgg catccccatt gctatgccca ccgtgctgag cgtgaccatg        900

gctattggca gccaccgcct gagccagcag ggcgctatta ccaagcgcat gaccgctatc        960

gaggagatgg ccggcatgga cgtgctgtgc agcgacaaga ccggcacgct gaccctgaac       1020

aagctgtccg tggaccgcaa cctggtcgag gtgttcgcta agggcgtcga caaggagtac       1080

gtcctgctgc tggctgctcg cgcttcccgc gtcgagaacc aggacgctat tgacgcttgc       1140

atggtcggca tgctggctga ccccaaggag gctcgcgctg gcattcgcga ggtccacttc       1200

ctgccgttca accccgtgga caagcgcacg gctctgacct acatcgacaa caacaacaac       1260

tggcaccgcg ccagcaaggg cgctcccgag cagattctgg acctgtgcaa cgctaaggag       1320

gacgtccgcc gcaaggtgca cagcatgatg gacaagtacg ctgagcgcgg cctgcgcagc       1380

ctggctgtgg ctcgccgcac ggtgcccgag aagtccaagg agagccccgg cggccgctgg       1440

gagttcgtgg gcctgctgcc gctgttcgac ccgccgcgcc acgacagcgc tgagaccatt       1500

cgccgcgctc tgaacctggg cgtgaacgtg aagatgatca ccggcgacca gctggcgatt       1560

gctaaggaga ccggccggcg cctgggcatg ggcaccaaca tgtacccctc cgcttcgctg       1620

ctgggccagg acaaggacag cgctattgct agcctgccga tcgaggagct gattgagaag       1680

gctgacggct tcgctggcgt gttccccgag cacaagtacg agatcgtgaa gaagctgcag       1740

gagcgcaagc acatcgtcgg catgaccggc gacggcgtga acgacgctcc ggctctgaag       1800

aaggccgaca ttggcattgc tgtggccgac gctaccgacg ccgctcgcgg cgctagcgac       1860

attgtcctga ccgagccggg cctgtccgtg attattagcg ctgtgctgac ctcgcgcgcc       1920

atcttccagc gcatgaagaa ctacaccatc tacgccgtgt ccatcaccat ccgcatcgtg       1980

ttcggcttca tgttcattgc cctgatctgg aagtacgact tcagcgcctt catggtgctg       2040

atcattgcca tcctgaacga cggcaccatc atgaccatca gcaaggaccg cgtgaagccc       2100

tcgccgatgc cggacagctg gaagctgaag gagattttcg ccaccggcgt ggtgctgggc       2160

ggctaccagg ctctgatgac cgtggtgttc ttctgggcca tgcacgacac cgacttcttc       2220

agcgacaagt tcggcgtgaa gtccctgcgc aacagcgacg aggagatgat gagcgcgctg       2280

tacctgcagg tgtcgatcat ctcgcaggcg ctgattttcg tgacccgcag ccgcagctgg       2340

tccttcctgg agcgcccggg catgctgctg gtcattgcct tcatgattgc ccagctggtg       2400

gcgaccctga tcgccgtgta cgctaactgg gctttcgctc gcgtgaaggg ctgcggctgg       2460

ggctgggctg gcgtgatctg gctgtactcc atcatcttct acctgccgct ggacatcatg       2520

aagttcgcca tccgctacat cctgagcggc aaggcttgga acaacctgct ggacaacaag       2580

accgccttca ccaccaagaa ggactacggc aaggaggagc gcgaggctca gtgggctctg       2640

gctcagcgca ccctgcacgg cctgcagccg ccggaggcta ccaacctgtt caacgagaag       2700

aacagctacc gcgagctgag cgagatcgcc gagcaggcta agcgccgcgc tgagatggct       2760

cggctgcgcg agctgcacac cctgaagggc cacgtcgaga gcgtggtcaa gctgaagggc       2820

ctggacatcg agaccatcca gcagcactac accgtg                                 2856


<210>    3
<211>    852
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of PMA4 Cter


<400>    3
Met Ala Lys Ala Ile Ser Leu Glu Glu Ile Lys Asn Glu Thr Val Asp
  1               5                  10                  15 

Leu Glu Lys Ile Pro Ile Glu Glu Val Phe Glu Gln Leu Lys Cys Thr
             20                  25                  30 

Arg Glu Gly Leu Ser Ala Asp Glu Gly Ala Ser Arg Leu Gln Ile Phe
         35                  40                  45 

Gly Pro Asn Lys Leu Glu Glu Lys Asn Glu Ser Lys Ile Leu Lys Phe
     50                  55                  60 

Leu Gly Phe Met Trp Asn Pro Leu Ser Trp Val Met Glu Ala Ala Ala
 65                  70                  75                  80 

Val Met Ala Ile Ala Leu Ala Asn Gly Asp Gly Lys Pro Pro Asp Trp
                 85                  90                  95 

Gln Asp Phe Ile Gly Ile Ile Cys Leu Leu Val Ile Asn Ser Thr Ile
            100                 105                 110 

Ser Phe Ile Glu Glu Asn Asn Ala Gly Asn Ala Ala Ala Ala Leu Met
        115                 120                 125 

Ala Gly Leu Ala Pro Lys Thr Lys Val Leu Arg Asp Gly Arg Trp Ser
    130                 135                 140 

Glu Gln Glu Ala Ala Ile Leu Val Pro Gly Asp Ile Ile Ser Val Lys
145                 150                 155                 160 

Leu Gly Asp Ile Ile Pro Ala Asp Ala Arg Leu Leu Glu Gly Asp Pro
                165                 170                 175 

Leu Lys Ile Asp Gln Ser Ala Leu Thr Gly Glu Ser Leu Pro Val Thr
            180                 185                 190 

Lys Asn Pro Gly Asp Glu Val Phe Ser Gly Ser Thr Cys Lys Gln Gly
        195                 200                 205 

Glu Leu Glu Ala Val Val Ile Ala Thr Gly Val His Thr Phe Phe Gly
    210                 215                 220 

Lys Ala Ala His Leu Val Asp Ser Thr Asn Asn Val Gly His Phe Gln
225                 230                 235                 240 

Lys Val Leu Thr Ala Ile Gly Asn Phe Cys Ile Cys Ser Ile Ala Ile
                245                 250                 255 

Gly Met Leu Val Glu Ile Ile Val Met Tyr Pro Ile Gln His Arg Lys
            260                 265                 270 

Tyr Arg Asp Gly Ile Asp Asn Leu Leu Val Leu Leu Ile Gly Gly Ile
        275                 280                 285 

Pro Ile Ala Met Pro Thr Val Leu Ser Val Thr Met Ala Ile Gly Ser
    290                 295                 300 

His Arg Leu Ser Gln Gln Gly Ala Ile Thr Lys Arg Met Thr Ala Ile
305                 310                 315                 320 

Glu Glu Met Ala Gly Met Asp Val Leu Cys Ser Asp Lys Thr Gly Thr
                325                 330                 335 

Leu Thr Leu Asn Lys Leu Ser Val Asp Arg Asn Leu Val Glu Val Phe
            340                 345                 350 

Ala Lys Gly Val Asp Lys Glu Tyr Val Leu Leu Leu Ala Ala Arg Ala
        355                 360                 365 

Ser Arg Val Glu Asn Gln Asp Ala Ile Asp Ala Cys Met Val Gly Met
    370                 375                 380 

Leu Ala Asp Pro Lys Glu Ala Arg Ala Gly Ile Arg Glu Val His Phe
385                 390                 395                 400 

Leu Pro Phe Asn Pro Val Asp Lys Arg Thr Ala Leu Thr Tyr Ile Asp
                405                 410                 415 

Asn Asn Asn Asn Trp His Arg Ala Ser Lys Gly Ala Pro Glu Gln Ile
            420                 425                 430 

Leu Asp Leu Cys Asn Ala Lys Glu Asp Val Arg Arg Lys Val His Ser
        435                 440                 445 

Met Met Asp Lys Tyr Ala Glu Arg Gly Leu Arg Ser Leu Ala Val Ala
    450                 455                 460 

Arg Arg Thr Val Pro Glu Lys Ser Lys Glu Ser Pro Gly Gly Arg Trp
465                 470                 475                 480 

Glu Phe Val Gly Leu Leu Pro Leu Phe Asp Pro Pro Arg His Asp Ser
                485                 490                 495 

Ala Glu Thr Ile Arg Arg Ala Leu Asn Leu Gly Val Asn Val Lys Met
            500                 505                 510 

Ile Thr Gly Asp Gln Leu Ala Ile Ala Lys Glu Thr Gly Arg Arg Leu
        515                 520                 525 

Gly Met Gly Thr Asn Met Tyr Pro Ser Ala Ser Leu Leu Gly Gln Asp
    530                 535                 540 

Lys Asp Ser Ala Ile Ala Ser Leu Pro Ile Glu Glu Leu Ile Glu Lys
545                 550                 555                 560 

Ala Asp Gly Phe Ala Gly Val Phe Pro Glu His Lys Tyr Glu Ile Val
                565                 570                 575 

Lys Lys Leu Gln Glu Arg Lys His Ile Val Gly Met Thr Gly Asp Gly
            580                 585                 590 

Val Asn Asp Ala Pro Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Val
        595                 600                 605 

Ala Asp Ala Thr Asp Ala Ala Arg Gly Ala Ser Asp Ile Val Leu Thr
    610                 615                 620 

Glu Pro Gly Leu Ser Val Ile Ile Ser Ala Val Leu Thr Ser Arg Ala
625                 630                 635                 640 

Ile Phe Gln Arg Met Lys Asn Tyr Thr Ile Tyr Ala Val Ser Ile Thr
                645                 650                 655 

Ile Arg Ile Val Phe Gly Phe Met Phe Ile Ala Leu Ile Trp Lys Tyr
            660                 665                 670 

Asp Phe Ser Ala Phe Met Val Leu Ile Ile Ala Ile Leu Asn Asp Gly
        675                 680                 685 

Thr Ile Met Thr Ile Ser Lys Asp Arg Val Lys Pro Ser Pro Met Pro
    690                 695                 700 

Asp Ser Trp Lys Leu Lys Glu Ile Phe Ala Thr Gly Val Val Leu Gly
705                 710                 715                 720 

Gly Tyr Gln Ala Leu Met Thr Val Val Phe Phe Trp Ala Met His Asp
                725                 730                 735 

Thr Asp Phe Phe Ser Asp Lys Phe Gly Val Lys Ser Leu Arg Asn Ser
            740                 745                 750 

Asp Glu Glu Met Met Ser Ala Leu Tyr Leu Gln Val Ser Ile Ile Ser
        755                 760                 765 

Gln Ala Leu Ile Phe Val Thr Arg Ser Arg Ser Trp Ser Phe Leu Glu
    770                 775                 780 

Arg Pro Gly Met Leu Leu Val Ile Ala Phe Met Ile Ala Gln Leu Val
785                 790                 795                 800 

Ala Thr Leu Ile Ala Val Tyr Ala Asn Trp Ala Phe Ala Arg Val Lys
                805                 810                 815 

Gly Cys Gly Trp Gly Trp Ala Gly Val Ile Trp Leu Tyr Ser Ile Ile
            820                 825                 830 

Phe Tyr Leu Pro Leu Asp Ile Met Lys Phe Ala Ile Arg Tyr Ile Leu
        835                 840                 845 

Ser Gly Lys Ala
    850        


<210>    4
<211>    2556
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    polynucleotide sequence of PMA4 Cter


<400>    4
atggccaagg ccatcagcct ggaggagatc aagaacgaga ccgtggacct ggagaagatc         60

cccatcgagg aggtgttcga gcagctgaag tgcacccgcg agggcctgag cgctgacgag        120

ggcgctagcc gcctgcagat tttcggcccc aacaagctgg aggagaagaa cgagagcaag        180

atcctgaagt tcctgggctt catgtggaac ccgctgagct gggtcatgga ggctgctgcc        240

gtgatggcta tcgctctggc taacggcgac ggcaagccgc cggactggca ggacttcatc        300

ggcatcattt gcctgctggt catcaacagc accatcagct tcattgagga gaacaacgcc        360

ggcaacgccg ctgccgctct gatggctggc ctggctccca agaccaaggt gctgcgcgac        420

ggccggtgga gcgagcagga ggccgctatt ctggtccccg gcgacatcat tagcgtgaag        480

ctgggcgaca ttatccccgc tgacgctcgc ctgctggagg gcgacccgct gaagattgac        540

cagtccgctc tgaccggcga gtcgctgccc gtgacgaaga acccgggcga cgaggtgttc        600

agcggctcga cctgcaagca gggcgagctg gaggctgtgg tcattgctac cggcgtgcac        660

accttcttcg gcaaggctgc tcacctggtg gacagcacca acaacgtggg ccacttccag        720

aaggtgctga ccgcgattgg caacttctgc atctgctcga tcgccatcgg catgctggtc        780

gagatcatcg tgatgtaccc catccagcac cgcaagtacc gcgacggcat tgacaacctg        840

ctggtgctgc tgattggcgg catccccatt gctatgccca ccgtgctgag cgtgaccatg        900

gctattggca gccaccgcct gagccagcag ggcgctatta ccaagcgcat gaccgctatc        960

gaggagatgg ccggcatgga cgtgctgtgc agcgacaaga ccggcacgct gaccctgaac       1020

aagctgtccg tggaccgcaa cctggtcgag gtgttcgcta agggcgtcga caaggagtac       1080

gtcctgctgc tggctgctcg cgcttcccgc gtcgagaacc aggacgctat tgacgcttgc       1140

atggtcggca tgctggctga ccccaaggag gctcgcgctg gcattcgcga ggtccacttc       1200

ctgccgttca accccgtgga caagcgcacg gctctgacct acatcgacaa caacaacaac       1260

tggcaccgcg ccagcaaggg cgctcccgag cagattctgg acctgtgcaa cgctaaggag       1320

gacgtccgcc gcaaggtgca cagcatgatg gacaagtacg ctgagcgcgg cctgcgcagc       1380

ctggctgtgg ctcgccgcac ggtgcccgag aagtccaagg agagccccgg cggccgctgg       1440

gagttcgtgg gcctgctgcc gctgttcgac ccgccgcgcc acgacagcgc tgagaccatt       1500

cgccgcgctc tgaacctggg cgtgaacgtg aagatgatca ccggcgacca gctggcgatt       1560

gctaaggaga ccggccggcg cctgggcatg ggcaccaaca tgtacccctc cgcttcgctg       1620

ctgggccagg acaaggacag cgctattgct agcctgccga tcgaggagct gattgagaag       1680

gctgacggct tcgctggcgt gttccccgag cacaagtacg agatcgtgaa gaagctgcag       1740

gagcgcaagc acatcgtcgg catgaccggc gacggcgtga acgacgctcc ggctctgaag       1800

aaggccgaca ttggcattgc tgtggccgac gctaccgacg ccgctcgcgg cgctagcgac       1860

attgtcctga ccgagccggg cctgtccgtg attattagcg ctgtgctgac ctcgcgcgcc       1920

atcttccagc gcatgaagaa ctacaccatc tacgccgtgt ccatcaccat ccgcatcgtg       1980

ttcggcttca tgttcattgc cctgatctgg aagtacgact tcagcgcctt catggtgctg       2040

atcattgcca tcctgaacga cggcaccatc atgaccatca gcaaggaccg cgtgaagccc       2100

tcgccgatgc cggacagctg gaagctgaag gagattttcg ccaccggcgt ggtgctgggc       2160

ggctaccagg ctctgatgac cgtggtgttc ttctgggcca tgcacgacac cgacttcttc       2220

agcgacaagt tcggcgtgaa gtccctgcgc aacagcgacg aggagatgat gagcgcgctg       2280

tacctgcagg tgtcgatcat ctcgcaggcg ctgattttcg tgacccgcag ccgcagctgg       2340

tccttcctgg agcgcccggg catgctgctg gtcattgcct tcatgattgc ccagctggtg       2400

gcgaccctga tcgccgtgta cgctaactgg gctttcgctc gcgtgaaggg ctgcggctgg       2460

ggctgggctg gcgtgatctg gctgtactcc atcatcttct acctgccgct ggacatcatg       2520

aagttcgcca tccgctacat cctgagcggc aaggct                                 2556
