                         SEQUENCE LISTING

<110>  CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD.
 
<120>  NOVEL SULFANAMIDE SERIES OF QR2 INHIBITORS TO TACKLE OXIDATIVE 
       STRESS AND COGNITIVE DECLINE

<130>  CRML-P-039-PCT

<150>  63/167,721
<151>  2021-03-30

<150>  63/279,486
<151>  2021-11-15

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Lys Lys Val Leu Ile Val Tyr Ala His Gln Glu Pro Lys 
1               5                   10                  15      


Ser Phe Asn Gly Ser Leu Lys Asn Val Ala Val Asp Glu Leu Ser Arg 
            20                  25                  30          


Gln Gly Cys Thr Val Thr Val Ser Asp Leu Tyr Ala Met Asn Leu Glu 
        35                  40                  45              


Pro Arg Ala Thr Asp Lys Asp Ile Thr Gly Thr Leu Ser Asn Pro Glu 
    50                  55                  60                  


Val Phe Asn Tyr Gly Val Glu Thr His Glu Ala Tyr Lys Gln Arg Ser 
65                  70                  75                  80  


Leu Ala Ser Asp Ile Thr Asp Glu Gln Lys Lys Val Arg Glu Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Tyr Trp Phe Ser Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Met Asp Arg Val Leu Cys Gln Gly Phe Ala Phe Asp 
        115                 120                 125             


Ile Pro Gly Phe Tyr Asp Ser Gly Leu Leu Gln Gly Lys Leu Ala Leu 
    130                 135                 140                 


Leu Ser Val Thr Thr Gly Gly Thr Ala Glu Met Tyr Thr Lys Thr Gly 
145                 150                 155                 160 


Val Asn Gly Asp Ser Arg Tyr Phe Leu Trp Pro Leu Gln His Gly Thr 
                165                 170                 175     


Leu His Phe Cys Gly Phe Lys Val Leu Ala Pro Gln Ile Ser Phe Ala 
            180                 185                 190         


Pro Glu Ile Ala Ser Glu Glu Glu Arg Lys Gly Met Val Ala Ala Trp 
        195                 200                 205             


Ser Gln Arg Leu Gln Thr Ile Trp Lys Glu Glu Pro Ile Pro Cys Thr 
    210                 215                 220                 


Ala His Trp His Phe Gly Gln 
225                 230     


<210>  2
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr 
1               5                   10                  15      


Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys 
            20                  25                  30          


Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn 
        35                  40                  45              


Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala 
    50                  55                  60                  


Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe Ala Tyr Thr 
        115                 120                 125             


Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys Lys Ala Val 
    130                 135                 140                 


Leu Ser Ile Thr Thr Gly Gly Ser Gly Ser Met Tyr Ser Leu Gln Gly 
145                 150                 155                 160 


Ile His Gly Asp Met Asn Val Ile Leu Trp Pro Ile Gln Ser Gly Ile 
                165                 170                 175     


Leu His Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser 
            180                 185                 190         


Ile Gly His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp 
        195                 200                 205             


Lys Lys Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala 
    210                 215                 220                 


Pro Ser Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe Leu Met Lys 
225                 230                 235                 240 


Lys Glu Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly Leu Ser Val 
                245                 250                 255     


Gly His His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala 
            260                 265                 270         


Arg Lys 
        


