                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  Gene Therapy for Retinal Disease

<130>  N420877WO

<150>  GB2104611.5
<151>  2021-03-31

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  DNA
<213>  adeno-associated virus 2

<400>  1
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt cct                                                         133


<210>  2
<211>  199
<212>  DNA
<213>  Homo sapiens

<400>  2
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccggg                                                   199


<210>  3
<211>  806
<212>  DNA
<213>  Homo sapiens

<400>  3
cagatcttcc ccacctagcc acctggcaaa ctgctccttc tctcaaaggc ccaaacatgg       60

cctcccagac tgcaaccccc aggcagtcag gccctgtctc cacaacctca cagccaccct      120

ggacggaatc tgcttcttcc cacatttgag tcctcctcag cccctgagct cctctgggca      180

gggctgtttc tttccatctt tgtattccca ggggcctgca aataaatgtt taatgaacga      240

acaagagagt gaattccaat tccatgcaac aaggattggg ctcctgggcc ctaggctatg      300

tgtctggcac cagaaacgga agctgcaggt tgcagcccct gccctcatgg agctcctcct      360

gtcagaggag tgtggggact ggatgactcc agaggtaact tgtgggggaa cgaacaggta      420

aggggctgtg tgacgagatg agagactggg agaataaacc agaaagtctc tagctgtcca      480

gaggacatag cacagaggcc catggtccct atttcaaacc caggccacca gactgagctg      540

ggaccttggg acagacaagt catgcagaag ttaggggacc ttctcctccc ttttcctgga      600

tcctgagtac ctctcctccc tgacctcagg cttcctccta gtgtcacctt ggcccctctt      660

agaagccaat taggccctca gtttctgcag cggggattaa tatgattatg aacaccccca      720

atctcccaga tgctgattca gccaggagct taggaggggg aggtcacttt ataagggtct      780

gggggggtca gaacccagag tcatcc                                           806


<210>  4
<211>  434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chicken beta-actin promoter exon-intron-exon (Ex/In/Ex)

<400>  4
tcgctgcgcg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc       60

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      120

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      180

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggctg tccgcggggg      240

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc      300

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc      360

aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aattggatcc tagcttgata      420

tcgaattcct gcag                                                        434


<210>  5
<211>  2580
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaggcgct gccggtgggc cgccctggcc ctggggctgc tgcgcctctg cttggctcag       60

gccaacttcg ccccgcactt cttcgacaac ggggtcggca gcaccaacgg aaacatggct      120

ctgttcagcc tcccagagga cacccctgta ggctctcacg tatacaccct gaatgggaca      180

gaccctgagg gagaccccat ctcctaccac atcagctttg accccagcac tagaagcgtc      240

ttttctgttg accccacttt tggaaacatc accctggttg aagagctgga cagagagagg      300

gaagatgaga ttgaagccat catcagcatt tctgatggcc tgaatctggt ggccgaaaaa      360

gtcgtgatcc tggtgaccga tgccaatgat gaggcgccca ggttcatcca ggagccttat      420

gttgccctgg ttcccgagga catacctgct gggagcatca tctttaaggt ccatgcagtg      480

gacagggaca caggctctgg agggagtgtc acctacttcc tgcagaacct gcactcccca      540

tttgccgtgg accgccacag cggtgtgctg cgcctccagg ctggggccac tctggactac      600

gagaggtccc ggacccacta catcaccgtg gtcgccaagg atggcggtgg gaggcttcat      660

ggggctgatg tggtgttctc agccaccacc acggtcacgg tcaatgtgga ggatgttcag      720

gacatggccc ctgtcttcgt gggcacaccc tactatggct atgtgtacga ggacaccctt      780

ccgggctcgg aggtactgaa ggtggtcgcc atggatggag accggggcaa acccaatcga      840

attctctaca gccttgtaaa tgggaacgat ggagcctttg aaattaatga gacatctgga      900

gccatctcca tcactcagag cccggcccag ctccagagag aggtgtatga gctgcatgta      960

caggtgactg aaatgagccc tgcggggagc ccagctgccc aggccaccgt cccagtcacc     1020

atcaggattg tggacctcaa caaccacccg ccaacattct atggagagag cggaccccaa     1080

aacaggtttg agctgtccat gaatgagcac ccaccccagg gagagatcct gcggggcctc     1140

aagatcaccg tcaatgactc cgaccaggga gccaatgcca aattcaactt gcagctggtg     1200

ggacccaggg gcatcttccg agtggttcca cagacagtcc tgaatgaagc ccaagtcaca     1260

atcattgtgg agaactcagc tgccattgac tttgaaaagt ccaaagtatt aaccttcaag     1320

ctcctggctg ttgaagtgaa caccccagag aagttcagtt ccacagcgga tgttgtgatc     1380

cagctcctgg acaccaatga caatgtcccc aagttcgact ccctctacta cgttgccagg     1440

attcctgaga acgccccagg gggctccagc gtggtggctg tcacagctgt ggatccagat     1500

acaggaccct ggggcgaagt gaaatattcc acctatggga ctggggcaga cctcttcctg     1560

atccacccat ccactgggct tatctacacc cagccctggg ctagcctgga cgctgaggcc     1620

actgccaggt acaacttcta tgtgaaggca gaggacatgg aaggcaagta cagcgtagct     1680

gaggtgttta tcacactgct ggatgtcaat gaccaccccc ctcagtttgg aaagagcgtt     1740

cagaagaaga cgatggtgct agggacccca gtgaaaattg aggccataga cgaggatgca     1800

gaggaaccca acaacctggt ggactattcc atcacccatg cagagcccgc caacgtgttc     1860

gacatcaatt cccacacggg ggagatctgg ctcaagaatt ccatccgctc cctggatgcc     1920

ctgcacaaca tcacacctgg aagggactgc ctatggtccc tagaggtgca ggccaaggac     1980

cggggctccc catccttcag caccacagcc ttactcaaga ttgacatcac agatgctgag     2040

accctctccc ggagccccat ggctgccttc ctgatacaga ccaaggacaa ccccatgaag     2100

gccgtgggtg tgctggccgg caccatggcc accgtcgtgg ccatcactgt cctcatctcc     2160

accgccacct tctggcgcaa caagaagtct aacaaggtcc tgccaatgcg gcgggtgctc     2220

cgcaagcggc ccagccctgc gccccgcacc atccgcattg agtggctcaa gtccaagagc     2280

accaaagccg ctaccaagtt catgctcaaa gagaaacctc ccaatgagaa ctgtaacaac     2340

aacagcccag aaagctctct gctcccgaga gctccggctc tccctccacc acccagcgtg     2400

gcgcccagca ctggcgcagc ccagtggacc gtgcctactg tctctggctc tctcactccg     2460

cagccgaccc aacccccgcc aaaacccaaa actatgggaa gccccgtcca gtcaactctg     2520

atctctgagc tcaagcaaaa gtttgagaag aagagtgtgc acaacaaggc ttacttctaa     2580


<210>  6
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Arg Cys Arg Trp Ala Ala Leu Ala Leu Gly Leu Leu Arg Leu 
1               5                   10                  15      


Cys Leu Ala Gln Ala Asn Phe Ala Pro His Phe Phe Asp Asn Gly Val 
            20                  25                  30          


Gly Ser Thr Asn Gly Asn Met Ala Leu Phe Ser Leu Pro Glu Asp Thr 
        35                  40                  45              


Pro Val Gly Ser His Val Tyr Thr Leu Asn Gly Thr Asp Pro Glu Gly 
    50                  55                  60                  


Asp Pro Ile Ser Tyr His Ile Ser Phe Asp Pro Ser Thr Arg Ser Val 
65                  70                  75                  80  


Phe Ser Val Asp Pro Thr Phe Gly Asn Ile Thr Leu Val Glu Glu Leu 
                85                  90                  95      


Asp Arg Glu Arg Glu Asp Glu Ile Glu Ala Ile Ile Ser Ile Ser Asp 
            100                 105                 110         


Gly Leu Asn Leu Val Ala Glu Lys Val Val Ile Leu Val Thr Asp Ala 
        115                 120                 125             


Asn Asp Glu Ala Pro Arg Phe Ile Gln Glu Pro Tyr Val Ala Leu Val 
    130                 135                 140                 


Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile Phe Lys Val His Ala Val 
145                 150                 155                 160 


Asp Arg Asp Thr Gly Ser Gly Gly Ser Val Thr Tyr Phe Leu Gln Asn 
                165                 170                 175     


Leu His Ser Pro Phe Ala Val Asp Arg His Ser Gly Val Leu Arg Leu 
            180                 185                 190         


Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg Ser Arg Thr His Tyr Ile 
        195                 200                 205             


Thr Val Val Ala Lys Asp Gly Gly Gly Arg Leu His Gly Ala Asp Val 
    210                 215                 220                 


Val Phe Ser Ala Thr Thr Thr Val Thr Val Asn Val Glu Asp Val Gln 
225                 230                 235                 240 


Asp Met Ala Pro Val Phe Val Gly Thr Pro Tyr Tyr Gly Tyr Val Tyr 
                245                 250                 255     


Glu Asp Thr Leu Pro Gly Ser Glu Val Leu Lys Val Val Ala Met Asp 
            260                 265                 270         


Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly 
        275                 280                 285             


Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile 
    290                 295                 300                 


Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val 
305                 310                 315                 320 


Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr 
                325                 330                 335     


Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr 
            340                 345                 350         


Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn 
        355                 360                 365             


Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu Lys Ile Thr Val 
    370                 375                 380                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn Leu Gln Leu Val 
385                 390                 395                 400 


Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr Val Leu Asn Glu 
                405                 410                 415     


Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala Ile Asp Phe Glu 
            420                 425                 430         


Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val Glu Val Asn Thr 
        435                 440                 445             


Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile Gln Leu Leu Asp 
    450                 455                 460                 


Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg 
465                 470                 475                 480 


Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val Ala Val Thr Ala 
                485                 490                 495     


Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr 
            500                 505                 510         


Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser Thr Gly Leu Ile 
        515                 520                 525             


Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr 
    530                 535                 540                 


Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys Tyr Ser Val Ala 
545                 550                 555                 560 


Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His Pro Pro Gln Phe 
                565                 570                 575     


Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly Thr Pro Val Lys 
            580                 585                 590         


Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn Asn Leu Val Asp 
        595                 600                 605             


Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe Asp Ile Asn Ser 
    610                 615                 620                 


His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala 
625                 630                 635                 640 


Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp Ser Leu Glu Val 
                645                 650                 655     


Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu 
            660                 665                 670         


Lys Ile Asp Ile Thr Asp Ala Glu Thr Leu Ser Arg Ser Pro Met Ala 
        675                 680                 685             


Ala Phe Leu Ile Gln Thr Lys Asp Asn Pro Met Lys Ala Val Gly Val 
    690                 695                 700                 


Leu Ala Gly Thr Met Ala Thr Val Val Ala Ile Thr Val Leu Ile Ser 
705                 710                 715                 720 


Thr Ala Thr Phe Trp Arg Asn Lys Lys Ser Asn Lys Val Leu Pro Met 
                725                 730                 735     


Arg Arg Val Leu Arg Lys Arg Pro Ser Pro Ala Pro Arg Thr Ile Arg 
            740                 745                 750         


Ile Glu Trp Leu Lys Ser Lys Ser Thr Lys Ala Ala Thr Lys Phe Met 
        755                 760                 765             


Leu Lys Glu Lys Pro Pro Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu 
    770                 775                 780                 


Ser Ser Leu Leu Pro Arg Ala Pro Ala Leu Pro Pro Pro Pro Ser Val 
785                 790                 795                 800 


Ala Pro Ser Thr Gly Ala Ala Gln Trp Thr Val Pro Thr Val Ser Gly 
                805                 810                 815     


Ser Leu Thr Pro Gln Pro Thr Gln Pro Pro Pro Lys Pro Lys Thr Met 
            820                 825                 830         


Gly Ser Pro Val Gln Ser Thr Leu Ile Ser Glu Leu Lys Gln Lys Phe 
        835                 840                 845             


Glu Lys Lys Ser Val His Asn Lys Ala Tyr Phe 
    850                 855                 


<210>  7
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  7
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  8
<211>  228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bovine growth hormone polyadenylation tail

<400>  8
cgactgtgcc ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga       60

ccctggaagg tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt      120

gtctgagtag gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg      180

attgggaaga caatagcagg catgctgggg atgcggtggg ctctatgg                   228


<210>  9
<211>  118
<212>  DNA
<213>  adeno-associated virus 2

<400>  9
tgcgcgctcg ctcgctcact gaggccgccc gggcgtcggg cgacctttgg tcgcccggcc       60

tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag gggttcct        118


<210>  10
<211>  3432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector GRK1.CDHR1.pA (5'ITR to 3'ITR, inclusive)

<400>  10
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtacc gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg      240

cggccccttg gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg      300

gattgtcttt ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg      360

atttagcctg gtgctgtgtc agccccgggg ttaacgccac catgaggcgc tgccggtggg      420

ccgccctggc cctggggctg ctgcgcctct gcttggctca ggccaacttc gccccgcact      480

tcttcgacaa cggggtcggc agcaccaacg gaaacatggc tctgttcagc ctcccagagg      540

acacccctgt aggctctcac gtatacaccc tgaatgggac agaccctgag ggagacccca      600

tctcctacca catcagcttt gaccccagca ctagaagcgt cttttctgtt gaccccactt      660

ttggaaacat caccctggtt gaagagctgg acagagagag ggaagatgag attgaagcca      720

tcatcagcat ttctgatggc ctgaatctgg tggccgaaaa agtcgtgatc ctggtgaccg      780

atgccaatga tgaggcgccc aggttcatcc aggagcctta tgttgccctg gttcccgagg      840

acatacctgc tgggagcatc atctttaagg tccatgcagt ggacagggac acaggctctg      900

gagggagtgt cacctacttc ctgcagaacc tgcactcccc atttgccgtg gaccgccaca      960

gcggtgtgct gcgcctccag gctggggcca ctctggacta cgagaggtcc cggacccact     1020

acatcaccgt ggtcgccaag gatggcggtg ggaggcttca tggggctgat gtggtgttct     1080

cagccaccac cacggtcacg gtcaatgtgg aggatgttca ggacatggcc cctgtcttcg     1140

tgggcacacc ctactatggc tatgtgtacg aggacaccct tccgggctcg gaggtactga     1200

aggtggtcgc catggatgga gaccggggca aacccaatcg aattctctac agccttgtaa     1260

atgggaacga tggagccttt gaaattaatg agacatctgg agccatctcc atcactcaga     1320

gcccggccca gctccagaga gaggtgtatg agctgcatgt acaggtgact gaaatgagcc     1380

ctgcggggag cccagctgcc caggccaccg tcccagtcac catcaggatt gtggacctca     1440

acaaccaccc gccaacattc tatggagaga gcggacccca aaacaggttt gagctgtcca     1500

tgaatgagca cccaccccag ggagagatcc tgcggggcct caagatcacc gtcaatgact     1560

ccgaccaggg agccaatgcc aaattcaact tgcagctggt gggacccagg ggcatcttcc     1620

gagtggttcc acagacagtc ctgaatgaag cccaagtcac aatcattgtg gagaactcag     1680

ctgccattga ctttgaaaag tccaaagtat taaccttcaa gctcctggct gttgaagtga     1740

acaccccaga gaagttcagt tccacagcgg atgttgtgat ccagctcctg gacaccaatg     1800

acaatgtccc caagttcgac tccctctact acgttgccag gattcctgag aacgccccag     1860

ggggctccag cgtggtggct gtcacagctg tggatccaga tacaggaccc tggggcgaag     1920

tgaaatattc cacctatggg actggggcag acctcttcct gatccaccca tccactgggc     1980

ttatctacac ccagccctgg gctagcctgg acgctgaggc cactgccagg tacaacttct     2040

atgtgaaggc agaggacatg gaaggcaagt acagcgtagc tgaggtgttt atcacactgc     2100

tggatgtcaa tgaccacccc cctcagtttg gaaagagcgt tcagaagaag acgatggtgc     2160

tagggacccc agtgaaaatt gaggccatag acgaggatgc agaggaaccc aacaacctgg     2220

tggactattc catcacccat gcagagcccg ccaacgtgtt cgacatcaat tcccacacgg     2280

gggagatctg gctcaagaat tccatccgct ccctggatgc cctgcacaac atcacacctg     2340

gaagggactg cctatggtcc ctagaggtgc aggccaagga ccggggctcc ccatccttca     2400

gcaccacagc cttactcaag attgacatca cagatgctga gaccctctcc cggagcccca     2460

tggctgcctt cctgatacag accaaggaca accccatgaa ggccgtgggt gtgctggccg     2520

gcaccatggc caccgtcgtg gccatcactg tcctcatctc caccgccacc ttctggcgca     2580

acaagaagtc taacaaggtc ctgccaatgc ggcgggtgct ccgcaagcgg cccagccctg     2640

cgccccgcac catccgcatt gagtggctca agtccaagag caccaaagcc gctaccaagt     2700

tcatgctcaa agagaaacct cccaatgaga actgtaacaa caacagccca gaaagctctc     2760

tgctcccgag agctccggct ctccctccac cacccagcgt ggcgcccagc actggcgcag     2820

cccagtggac cgtgcctact gtctctggct ctctcactcc gcagccgacc caacccccgc     2880

caaaacccaa aactatggga agccccgtcc agtcaactct gatctctgag ctcaagcaaa     2940

agtttgagaa gaagagtgtg cacaacaagg cttacttcta aaagctctcg ctgatcagcc     3000

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     3060

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     3120

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     3180

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg     3240

gaaagaacca gctggggctc gactagagca tggctacgta gataagtagc atggcgggtt     3300

aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     3360

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc tcagtgagcg     3420

agcgagcgcg ca                                                         3432


<210>  11
<211>  4056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector GRK1.CDHR1.WPRE.pA (5'ITR to 3'ITR, inclusive)

<400>  11
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtacc gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg      240

cggccccttg gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg      300

gattgtcttt ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg      360

atttagcctg gtgctgtgtc agccccgggg ttattgttaa cgccaccatg aggcgctgcc      420

ggtgggccgc cctggccctg gggctgctgc gcctctgctt ggctcaggcc aacttcgccc      480

cgcacttctt cgacaacggg gtcggcagca ccaacggaaa catggctctg ttcagcctcc      540

cagaggacac ccctgtaggc tctcacgtat acaccctgaa tgggacagac cctgagggag      600

accccatctc ctaccacatc agctttgacc ccagcactag aagcgtcttt tctgttgacc      660

ccacttttgg aaacatcacc ctggttgaag agctggacag agagagggaa gatgagattg      720

aagccatcat cagcatttct gatggcctga atctggtggc cgaaaaagtc gtgatcctgg      780

tgaccgatgc caatgatgag gcgcccaggt tcatccagga gccttatgtt gccctggttc      840

ccgaggacat acctgctggg agcatcatct ttaaggtcca tgcagtggac agggacacag      900

gctctggagg gagtgtcacc tacttcctgc agaacctgca ctccccattt gccgtggacc      960

gccacagcgg tgtgctgcgc ctccaggctg gggccactct ggactacgag aggtcccgga     1020

cccactacat caccgtggtc gccaaggatg gcggtgggag gcttcatggg gctgatgtgg     1080

tgttctcagc caccaccacg gtcacggtca atgtggagga tgttcaggac atggcccctg     1140

tcttcgtggg cacaccctac tatggctatg tgtacgagga cacccttccg ggctcggagg     1200

tactgaaggt ggtcgccatg gatggagacc ggggcaaacc caatcgaatt ctctacagcc     1260

ttgtaaatgg gaacgatgga gcctttgaaa ttaatgagac atctggagcc atctccatca     1320

ctcagagccc ggcccagctc cagagagagg tgtatgagct gcatgtacag gtgactgaaa     1380

tgagccctgc ggggagccca gctgcccagg ccaccgtccc agtcaccatc aggattgtgg     1440

acctcaacaa ccacccgcca acattctatg gagagagcgg accccaaaac aggtttgagc     1500

tgtccatgaa tgagcaccca ccccagggag agatcctgcg gggcctcaag atcaccgtca     1560

atgactccga ccagggagcc aatgccaaat tcaacttgca gctggtggga cccaggggca     1620

tcttccgagt ggttccacag acagtcctga atgaagccca agtcacaatc attgtggaga     1680

actcagctgc cattgacttt gaaaagtcca aagtattaac cttcaagctc ctggctgttg     1740

aagtgaacac cccagagaag ttcagttcca cagcggatgt tgtgatccag ctcctggaca     1800

ccaatgacaa tgtccccaag ttcgactccc tctactacgt tgccaggatt cctgagaacg     1860

ccccaggggg ctccagcgtg gtggctgtca cagctgtgga tccagataca ggaccctggg     1920

gcgaagtgaa atattccacc tatgggactg gggcagacct cttcctgatc cacccatcca     1980

ctgggcttat ctacacccag ccctgggcta gcctggacgc tgaggccact gccaggtaca     2040

acttctatgt gaaggcagag gacatggaag gcaagtacag cgtagctgag gtgtttatca     2100

cactgctgga tgtcaatgac cacccccctc agtttggaaa gagcgttcag aagaagacga     2160

tggtgctagg gaccccagtg aaaattgagg ccatagacga ggatgcagag gaacccaaca     2220

acctggtgga ctattccatc acccatgcag agcccgccaa cgtgttcgac atcaattccc     2280

acacggggga gatctggctc aagaattcca tccgctccct ggatgccctg cacaacatca     2340

cacctggaag ggactgccta tggtccctag aggtgcaggc caaggaccgg ggctccccat     2400

ccttcagcac cacagcctta ctcaagattg acatcacaga tgctgagacc ctctcccgga     2460

gccccatggc tgccttcctg atacagacca aggacaaccc catgaaggcc gtgggtgtgc     2520

tggccggcac catggccacc gtcgtggcca tcactgtcct catctccacc gccaccttct     2580

ggcgcaacaa gaagtctaac aaggtcctgc caatgcggcg ggtgctccgc aagcggccca     2640

gccctgcgcc ccgcaccatc cgcattgagt ggctcaagtc caagagcacc aaagccgcta     2700

ccaagttcat gctcaaagag aaacctccca atgagaactg taacaacaac agcccagaaa     2760

gctctctgct cccgagagct ccggctctcc ctccaccacc cagcgtggcg cccagcactg     2820

gcgcagccca gtggaccgtg cctactgtct ctggctctct cactccgcag ccgacccaac     2880

ccccgccaaa acccaaaact atgggaagcc ccgtccagtc aactctgatc tctgagctca     2940

agcaaaagtt tgagaagaag agtgtgcaca acaaggctta cttctaaaag cttgggagct     3000

tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     3060

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     3120

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     3180

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     3240

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     3300

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     3360

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     3420

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     3480

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     3540

gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg     3600

ataccgtcga ctcgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt     3660

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     3720

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     3780

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     3840

gtgggctcta tggcttctga ggcggaaaga accagctggg gctcgactag agcatggcta     3900

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     3960

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4020

acgcccgggc ggcctcagtg agcgagcgag cgcgca                               4056


<210>  12
<211>  4491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vector GRK1.In.CDHR1.WPRE.pA (5'ITR to 3'ITR, inclusive)

<400>  12
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtacc gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg      240

cggccccttg gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg      300

gattgtcttt ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg      360

atttagcctg gtgctgtgtc agccccgggg ttattgtttc gctgcgcgct gccttcgccc      420

cgtgccccgc tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact      480

cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta      540

atgacggctt gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc      600

tttgtgcggg gggagcggct cggggctgtc cgcgggggga cggctgcctt cgggggggac      660

ggggcagggc ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc      720

atgttcatgc cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt      780

ctcatcattt tggcaaagaa ttggatccta gcttgatatc gaattcctgc agcaacgcca      840

ccaugaggcg cugccggugg gccgcccugg cccuggggcu gcugcgccuc ugcuuggcuc      900

aggccaacuu cgccccgcac uucuucgaca acggggucgg cagcaccaac ggaaacaugg      960

cucuguucag ccucccagag gacaccccug uaggcucuca cguauacacc cugaauggga     1020

cagacccuga gggagacccc aucuccuacc acaucagcuu ugaccccagc acuagaagcg     1080

ucuuuucugu ugaccccacu uuuggaaaca ucacccuggu ugaagagcug gacagagaga     1140

gggaagauga gauugaagcc aucaucagca uuucugaugg ccugaaucug guggccgaaa     1200

aagucgugau ccuggugacc gaugccaaug augaggcgcc cagguucauc caggagccuu     1260

auguugcccu gguucccgag gacauaccug cugggagcau caucuuuaag guccaugcag     1320

uggacaggga cacaggcucu ggagggagug ucaccuacuu ccugcagaac cugcacuccc     1380

cauuugccgu ggaccgccac agcggugugc ugcgccucca ggcuggggcc acucuggacu     1440

acgagagguc ccggacccac uacaucaccg uggucgccaa ggauggcggu gggaggcuuc     1500

auggggcuga ugugguguuc ucagccacca ccacggucac ggucaaugug gaggauguuc     1560

aggacauggc cccugucuuc gugggcacac ccuacuaugg cuauguguac gaggacaccc     1620

uuccgggcuc ggagguacug aagguggucg ccauggaugg agaccggggc aaacccaauc     1680

gaauucucua cagccuugua aaugggaacg auggagccuu ugaaauuaau gagacaucug     1740

gagccaucuc caucacucag agcccggccc agcuccagag agagguguau gagcugcaug     1800

uacaggugac ugaaaugagc ccugcgggga gcccagcugc ccaggccacc gucccaguca     1860

ccaucaggau uguggaccuc aacaaccacc cgccaacauu cuauggagag agcggacccc     1920

aaaacagguu ugagcugucc augaaugagc acccacccca gggagagauc cugcggggcc     1980

ucaagaucac cgucaaugac uccgaccagg gagccaaugc caaauucaac uugcagcugg     2040

ugggacccag gggcaucuuc cgagugguuc cacagacagu ccugaaugaa gcccaaguca     2100

caaucauugu ggagaacuca gcugccauug acuuugaaaa guccaaagua uuaaccuuca     2160

agcuccuggc uguugaagug aacaccccag agaaguucag uuccacagcg gauguuguga     2220

uccagcuccu ggacaccaau gacaaugucc ccaaguucga cucccucuac uacguugcca     2280

ggauuccuga gaacgcccca gggggcucca gcgugguggc ugucacagcu guggauccag     2340

auacaggacc cuggggcgaa gugaaauauu ccaccuaugg gacuggggca gaccucuucc     2400

ugauccaccc auccacuggg cuuaucuaca cccagcccug ggcuagccug gacgcugagg     2460

ccacugccag guacaacuuc uaugugaagg cagaggacau ggaaggcaag uacagcguag     2520

cugagguguu uaucacacug cuggauguca augaccaccc cccucaguuu ggaaagagcg     2580

uucagaagaa gacgauggug cuagggaccc cagugaaaau ugaggccaua gacgaggaug     2640

cagaggaacc caacaaccug guggacuauu ccaucaccca ugcagagccc gccaacgugu     2700

ucgacaucaa uucccacacg ggggagaucu ggcucaagaa uuccauccgc ucccuggaug     2760

cccugcacaa caucacaccu ggaagggacu gccuaugguc ccuagaggug caggccaagg     2820

accggggcuc cccauccuuc agcaccacag ccuuacucaa gauugacauc acagaugcug     2880

agacccucuc ccggagcccc auggcugccu uccugauaca gaccaaggac aaccccauga     2940

aggccguggg ugugcuggcc ggcaccaugg ccaccgucgu ggccaucacu guccucaucu     3000

ccaccgccac cuucuggcgc aacaagaagu cuaacaaggu ccugccaaug cggcgggugc     3060

uccgcaagcg gcccagcccu gcgccccgca ccauccgcau ugaguggcuc aaguccaaga     3120

gcaccaaagc cgcuaccaag uucaugcuca aagagaaacc ucccaaugag aacuguaaca     3180

acaacagccc agaaagcucu cugcucccga gagcuccggc ucucccucca ccacccagcg     3240

uggcgcccag cacuggcgca gcccagugga ccgugccuac ugucucuggc ucucucacuc     3300

cgcagccgac ccaacccccg ccaaaaccca aaacuauggg aagccccguc cagucaacuc     3360

ugaucucuga gcucaagcaa aaguuugaga agaagagugu gcacaacaag gcuuacuucu     3420

agaagcttgg gagcttatcg ataatcaacc tctggattac aaaatttgtg aaagattgac     3480

tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt     3540

gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt     3600

gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt     3660

gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg     3720

gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg     3780

ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc     3840

atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt     3900

ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc     3960

tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc     4020

cgcctccccg catcgatacc gtcgactcgc tgatcagcct cgactgtgcc ttctagttgc     4080

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     4140

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     4200

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     4260

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctcg     4320

actagagcat ggctacgtag ataagtagca tggcgggtta atcattaact acaaggaacc     4380

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     4440

accaaaggtc gcccgacgcc cgggcggcct cagtgagcga gcgagcgcgc a              4491


<210>  13
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  13

Phe Ser Leu Pro Glu Asp Thr Pro Val Gly Ser His Val Tyr Thr Leu 
1               5                   10                  15      


Asn Gly Thr Asp Pro Glu Gly Asp Pro Ile Ser Tyr His Ile Ser Phe 
            20                  25                  30          


Asp Pro Ser Thr Arg Ser Val Phe Ser Val Asp Pro Thr Phe Gly Asn 
        35                  40                  45              


Ile Thr Leu Val Glu Glu Leu Asp Arg Glu Arg Glu Asp Glu Ile Glu 
    50                  55                  60                  


Ala Ile Ile Ser Ile Ser Asp Gly Leu Asn Leu Val Ala Glu Lys Val 
65                  70                  75                  80  


Val Ile Leu Val Thr Asp Ala Asn Asp 
                85                  


<210>  14
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Tyr Val Ala Leu Val Pro Glu Asp Ile Pro Ala Gly Ser Ile Ile 
1               5                   10                  15      


Phe Lys Val His Ala Val Asp Arg Asp Thr Gly Ser Gly Gly Ser Val 
            20                  25                  30          


Thr Tyr Phe Leu Gln Asn Leu His Ser Pro Phe Ala Val Asp Arg His 
        35                  40                  45              


Ser Gly Val Leu Arg Leu Gln Ala Gly Ala Thr Leu Asp Tyr Glu Arg 
    50                  55                  60                  


Ser Arg Thr His Tyr Ile Thr Val Val Ala Lys Asp Gly Gly Gly Arg 
65                  70                  75                  80  


Leu His Gly Ala Asp Val Val Phe Ser Ala Thr Thr Thr Val Thr Val 
                85                  90                  95      


Asn Val Glu Asp Val Gln Asp 
            100             


<210>  15
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Tyr Tyr Gly Tyr Val Tyr Glu Asp Thr Leu Pro Gly Ser Glu Val 
1               5                   10                  15      


Leu Lys Val Val Ala Met Asp Gly Asp Arg Gly Lys Pro Asn Arg Ile 
            20                  25                  30          


Leu Tyr Ser Leu Val Asn Gly Asn Asp Gly Ala Phe Glu Ile Asn Glu 
        35                  40                  45              


Thr Ser Gly Ala Ile Ser Ile Thr Gln Ser Pro Ala Gln Leu Gln Arg 
    50                  55                  60                  


Glu Val Tyr Glu Leu His Val Gln Val Thr Glu Met Ser Pro Ala Gly 
65                  70                  75                  80  


Ser Pro Ala Ala Gln Ala Thr Val Pro Val Thr Ile Arg Ile Val Asp 
                85                  90                  95      


Leu Asn Asn His 
            100 


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Glu Leu Ser Met Asn Glu His Pro Pro Gln Gly Glu Ile Leu Arg 
1               5                   10                  15      


Gly Leu Lys Ile Thr Val Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys 
            20                  25                  30          


Phe Asn Leu Gln Leu Val Gly Pro Arg Gly Ile Phe Arg Val Val Pro 
        35                  40                  45              


Gln Thr Val Leu Asn Glu Ala Gln Val Thr Ile Ile Val Glu Asn Ser 
    50                  55                  60                  


Ala Ala Ile Asp Phe Glu Lys Ser Lys Val Leu Thr Phe Lys Leu Leu 
65                  70                  75                  80  


Ala Val Glu Val Asn Thr Pro Glu Lys Phe Ser Ser Thr Ala Asp Val 
                85                  90                  95      


Val Ile Gln Leu Leu Asp Thr Asn Asp Asn 
            100                 105     


<210>  17
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  17

Tyr Val Ala Arg Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val 
1               5                   10                  15      


Ala Val Thr Ala Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys 
            20                  25                  30          


Tyr Ser Thr Tyr Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser 
        35                  40                  45              


Thr Gly Leu Ile Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala 
    50                  55                  60                  


Thr Ala Arg Tyr Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys 
65                  70                  75                  80  


Tyr Ser Val Ala Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His 
                85                  90                  95      


<210>  18
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Thr Pro Val Lys Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro 
1               5                   10                  15      


Asn Asn Leu Val Asp Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val 
            20                  25                  30          


Phe Asp Ile Asn Ser His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile 
        35                  40                  45              


Arg Ser Leu Asp Ala Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu 
    50                  55                  60                  


Trp Ser Leu Glu Val Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser 
65                  70                  75                  80  


Thr Thr Ala Leu Leu Lys Ile Asp Ile Thr Asp Ala 
                85                  90          


