                         SEQUENCE LISTING

<110>  JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
 
<120>  Novel TNFR2 binding molecules

<130>  N420734WO

<150>  EP21166756.3
<151>  2021-04-01

<160>  338   

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  2
<211>  30
<212>  PRT
<213>  Gallus Gallus Domesticus

<400>  2

Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg 
1               5                   10                  15      


Leu Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln 
            20                  25                  30  


<210>  3
<211>  254
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-010pre LC

<400>  3

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 


<210>  4
<211>  414
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-030pre LC

<400>  4

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Ile Val Met 
            20                  25                  30          


Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser 
        35                  40                  45              


Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
65                  70                  75                  80  


Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            100                 105                 110         


Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
145                 150                 155                 160 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
                165                 170                 175     


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
            180                 185                 190         


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
        195                 200                 205             


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
    210                 215                 220                 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
225                 230                 235                 240 


Arg Gly Glu Cys Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn 
                245                 250                 255     


Ile Val Ala Val Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp 
            260                 265                 270         


Arg Gly Lys Leu Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu 
        275                 280                 285             


Met Glu Ala Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile 
    290                 295                 300                 


Cys Leu Ser His Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro 
305                 310                 315                 320 


Gly Arg Cys His Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly 
                325                 330                 335     


Ile Gly Glu Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp 
            340                 345                 350         


Leu Glu Pro Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp 
        355                 360                 365             


Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp 
    370                 375                 380                 


Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys 
385                 390                 395                 400 


Ile Gln Gly Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
                405                 410                 


<210>  5
<211>  501
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-013pre LC

<400>  5

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu 
                245                 250                 255     


Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
        275                 280                 285             


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val 
    290                 295                 300                 


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe 
305                 310                 315                 320 


Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
                325                 330                 335     


Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
            340                 345                 350         


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu 
    370                 375                 380                 


Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp Ile Val Met Thr Gln 
385                 390                 395                 400 


Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr 
                405                 410                 415     


Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
        435                 440                 445             


His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Glu Ile Lys 
            500     


<210>  6
<211>  395
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-022 LC

<400>  6

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
            180                 185                 190         


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
        195                 200                 205             


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
                245                 250                 255     


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Glu Ile Lys 
        275                 280                 285             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    290                 295                 300                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
305                 310                 315                 320 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                325                 330                 335     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            340                 345                 350         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        355                 360                 365             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    370                 375                 380                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
385                 390                 395 


<210>  7
<211>  642
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-023 LC

<400>  7

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
            180                 185                 190         


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
        195                 200                 205             


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
                245                 250                 255     


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Glu Ile Lys 
        275                 280                 285             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    290                 295                 300                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
305                 310                 315                 320 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                325                 330                 335     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            340                 345                 350         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        355                 360                 365             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    370                 375                 380                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu Gln Val Gln 
385                 390                 395                 400 


Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
                405                 410                 415     


Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn 
            420                 425                 430         


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile 
        435                 440                 445             


Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys 
    450                 455                 460                 


Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu 
465                 470                 475                 480 


His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu 
                485                 490                 495     


Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
            500                 505                 510         


Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly 
        515                 520                 525             


Glu Phe Ser Glu Ala Gln Leu Asp Ile Val Met Thr Gln Ser His Lys 
    530                 535                 540                 


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
545                 550                 555                 560 


Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                565                 570                 575     


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly 
            580                 585                 590         


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        595                 600                 605             


Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln 
    610                 615                 620                 


Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
625                 630                 635                 640 


Ile Lys 
        


<210>  8
<211>  256
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-005 LC

<400>  8

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Ala Gln Ser Gln Lys Phe 
        35                  40                  45              


Met Ser Val Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            100                 105                 110         


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
        115                 120                 125             


Phe Asp Ser His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
    130                 135                 140                 


Lys Gly Ser Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
                165                 170                 175     


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
            180                 185                 190         


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
    210                 215                 220                 


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
225                 230                 235                 240 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
                245                 250                 255     


<210>  9
<211>  417
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-032 LC

<400>  9

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Ile Val Met 
            20                  25                  30          


Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val Gly Asp Arg Val Ser 
        35                  40                  45              


Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr 
    50                  55                  60                  


Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser 
65                  70                  75                  80  


Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
            100                 105                 110         


Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro Leu Thr Phe Gly Ala 
        115                 120                 125             


Gly Thr Lys Leu Glu Leu Lys Gly Ser Glu Ile Lys Arg Thr Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
145                 150                 155                 160 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
                165                 170                 175     


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
            180                 185                 190         


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
        195                 200                 205             


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
    210                 215                 220                 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
225                 230                 235                 240 


Ser Phe Asn Arg Gly Glu Cys Leu Glu Lys Pro Thr Glu Asn Asn Glu 
                245                 250                 255     


Asp Phe Asn Ile Val Ala Val Ala Ser Asn Phe Ala Thr Thr Asp Leu 
            260                 265                 270         


Asp Ala Asp Arg Gly Lys Leu Pro Gly Lys Lys Leu Pro Leu Glu Val 
        275                 280                 285             


Leu Lys Glu Met Glu Ala Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly 
    290                 295                 300                 


Cys Leu Ile Cys Leu Ser His Ile Lys Cys Thr Pro Lys Met Lys Lys 
305                 310                 315                 320 


Phe Ile Pro Gly Arg Cys His Thr Tyr Glu Gly Asp Lys Glu Ser Ala 
                325                 330                 335     


Gln Gly Gly Ile Gly Glu Ala Ile Val Asp Ile Pro Glu Ile Pro Gly 
            340                 345                 350         


Phe Lys Asp Leu Glu Pro Met Glu Gln Phe Ile Ala Gln Val Asp Leu 
        355                 360                 365             


Cys Val Asp Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala Asn Val Gln 
    370                 375                 380                 


Cys Ser Asp Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe 
385                 390                 395                 400 


Ala Ser Lys Ile Gln Gly Gln Val Asp Lys Ile Lys Gly Ala Gly Gly 
                405                 410                 415     


Asp 
    


<210>  10
<211>  257
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-092 LC

<400>  10

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asn Ile Val Met Thr Gln Ser Pro Lys Ser 
        35                  40                  45              


Leu Ser Met Ser Val Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser 
    50                  55                  60                  


Glu Asn Val Lys Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln 
        115                 120                 125             


Ser Tyr Ser Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Arg 
    130                 135                 140                 


Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                165                 170                 175     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            180                 185                 190         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        195                 200                 205             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    210                 215                 220                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
225                 230                 235                 240 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                245                 250                 255     


Cys 
    


<210>  11
<211>  427
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-093 LC

<400>  11

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asn Ile Val Met Thr Gln Ser Pro Lys Ser 
        35                  40                  45              


Leu Ser Met Ser Val Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser 
    50                  55                  60                  


Glu Asn Val Lys Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln 
        115                 120                 125             


Ser Tyr Ser Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Arg 
    130                 135                 140                 


Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                165                 170                 175     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            180                 185                 190         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        195                 200                 205             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    210                 215                 220                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
225                 230                 235                 240 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                245                 250                 255     


Cys Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala 
            260                 265                 270         


Val Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys 
        275                 280                 285             


Leu Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala 
    290                 295                 300                 


Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser 
305                 310                 315                 320 


His Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys 
                325                 330                 335     


His Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu 
            340                 345                 350         


Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro 
        355                 360                 365             


Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr 
    370                 375                 380                 


Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys 
385                 390                 395                 400 


Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly 
                405                 410                 415     


Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            420                 425         


<210>  12
<211>  256
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-077 LC

<400>  12

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        35                  40                  45              


Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Ile Asn Lys Phe Ile Ala Trp Tyr Gln His Lys Pro Gly Lys 
65                  70                  75                  80  


Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile 
                85                  90                  95      


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser 
            100                 105                 110         


Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln 
        115                 120                 125             


Tyr Asp Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    130                 135                 140                 


Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                165                 170                 175     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            180                 185                 190         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
    210                 215                 220                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
225                 230                 235                 240 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 255     


<210>  13
<211>  426
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-076 LC

<400>  13

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
        35                  40                  45              


Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Ile Asn Lys Phe Ile Ala Trp Tyr Gln His Lys Pro Gly Lys 
65                  70                  75                  80  


Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile 
                85                  90                  95      


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser 
            100                 105                 110         


Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln 
        115                 120                 125             


Tyr Asp Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    130                 135                 140                 


Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                165                 170                 175     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            180                 185                 190         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
    210                 215                 220                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
225                 230                 235                 240 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 255     


Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val 
            260                 265                 270         


Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu 
        275                 280                 285             


Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn 
    290                 295                 300                 


Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His 
305                 310                 315                 320 


Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His 
                325                 330                 335     


Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala 
            340                 345                 350         


Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Met 
        355                 360                 365             


Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly 
    370                 375                 380                 


Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys 
385                 390                 395                 400 


Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln 
                405                 410                 415     


Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            420                 425     


<210>  14
<211>  257
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-016pre LC

<400>  14

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Ala Gln Ser Gln Lys Phe 
        35                  40                  45              


Met Ser Val Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            100                 105                 110         


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln 
        115                 120                 125             


Phe Asp Ser His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
    130                 135                 140                 


Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                165                 170                 175     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            180                 185                 190         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        195                 200                 205             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    210                 215                 220                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
225                 230                 235                 240 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                245                 250                 255     


Cys 
    


<210>  15
<211>  420
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-028 LC

<400>  15

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Ala Val Val 
            20                  25                  30          


Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr Leu 
        35                  40                  45              


Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
    50                  55                  60                  


Trp Ile Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly 
65                  70                  75                  80  


Thr Asn Asn Arg Thr Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu 
                85                  90                  95      


Ile Gly Asp Lys Ala Ala Leu Thr Val Thr Gly Ala Gln Thr Glu Asp 
            100                 105                 110         


Glu Ala Val Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His Trp Val Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg Ser Glu Ile Lys Arg 
    130                 135                 140                 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
145                 150                 155                 160 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
                165                 170                 175     


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
            180                 185                 190         


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
        195                 200                 205             


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
    210                 215                 220                 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
225                 230                 235                 240 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu Lys Pro Thr Glu 
                245                 250                 255     


Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser Asn Phe Ala Thr 
            260                 265                 270         


Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly Lys Lys Leu Pro 
        275                 280                 285             


Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala Arg Lys Ala Gly Cys 
    290                 295                 300                 


Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys Cys Thr Pro Lys 
305                 310                 315                 320 


Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr Glu Gly Asp Lys 
                325                 330                 335     


Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile Val Asp Ile Pro Glu 
            340                 345                 350         


Ile Pro Gly Phe Lys Asp Leu Glu Pro Met Glu Gln Phe Ile Ala Gln 
        355                 360                 365             


Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala 
    370                 375                 380                 


Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys 
385                 390                 395                 400 


Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val Asp Lys Ile Lys Gly 
                405                 410                 415     


Ala Gly Gly Asp 
            420 


<210>  16
<211>  426
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-087 LC

<400>  16

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
        35                  40                  45              


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
    50                  55                  60                  


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
65                  70                  75                  80  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
                85                  90                  95      


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
            100                 105                 110         


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
        115                 120                 125             


Ser Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    130                 135                 140                 


Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                165                 170                 175     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            180                 185                 190         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
    210                 215                 220                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
225                 230                 235                 240 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 255     


Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val 
            260                 265                 270         


Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu 
        275                 280                 285             


Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn 
    290                 295                 300                 


Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His 
305                 310                 315                 320 


Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His 
                325                 330                 335     


Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala 
            340                 345                 350         


Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Met 
        355                 360                 365             


Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly 
    370                 375                 380                 


Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys 
385                 390                 395                 400 


Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln 
                405                 410                 415     


Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            420                 425     


<210>  17
<211>  432
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-090 LC

<400>  17

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Val Val Met Thr Gln Thr Pro Leu Ser 
        35                  40                  45              


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ala Ser 
    50                  55                  60                  


Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu 
65                  70                  75                  80  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
                85                  90                  95      


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            100                 105                 110         


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
        115                 120                 125             


Phe Phe Cys Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Ser Gly 
    130                 135                 140                 


Thr Lys Leu Glu Ile Lys Gly Ser Glu Ile Lys Arg Thr Val Ala Ala 
145                 150                 155                 160 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
                165                 170                 175     


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
            180                 185                 190         


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
        195                 200                 205             


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
    210                 215                 220                 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
                245                 250                 255     


Phe Asn Arg Gly Glu Cys Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp 
            260                 265                 270         


Phe Asn Ile Val Ala Val Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp 
        275                 280                 285             


Ala Asp Arg Gly Lys Leu Pro Gly Lys Lys Leu Pro Leu Glu Val Leu 
    290                 295                 300                 


Lys Glu Met Glu Ala Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys 
305                 310                 315                 320 


Leu Ile Cys Leu Ser His Ile Lys Cys Thr Pro Lys Met Lys Lys Phe 
                325                 330                 335     


Ile Pro Gly Arg Cys His Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln 
            340                 345                 350         


Gly Gly Ile Gly Glu Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe 
        355                 360                 365             


Lys Asp Leu Glu Pro Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys 
    370                 375                 380                 


Val Asp Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys 
385                 390                 395                 400 


Ser Asp Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala 
                405                 410                 415     


Ser Lys Ile Gln Gly Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            420                 425                 430         


<210>  18
<211>  430
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-071 LC

<400>  18

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Ala Val Val Thr Gln Glu Ser Ala Leu 
        35                  40                  45              


Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
    50                  55                  60                  


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro 
65                  70                  75                  80  


Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro 
                85                  90                  95      


Gly Val Pro Ala Arg Phe Ser Gly Ser Val Ile Gly Asp Lys Ala Ala 
            100                 105                 110         


Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys 
        115                 120                 125             


Ala Leu Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu 
    130                 135                 140                 


Thr Val Leu Gly Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
145                 150                 155                 160 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                165                 170                 175     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            180                 185                 190         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        195                 200                 205             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    210                 215                 220                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
225                 230                 235                 240 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                245                 250                 255     


Arg Gly Glu Cys Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn 
            260                 265                 270         


Ile Val Ala Val Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp 
        275                 280                 285             


Arg Gly Lys Leu Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu 
    290                 295                 300                 


Met Glu Ala Asn Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile 
305                 310                 315                 320 


Cys Leu Ser His Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro 
                325                 330                 335     


Gly Arg Cys His Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly 
            340                 345                 350         


Ile Gly Glu Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp 
        355                 360                 365             


Leu Glu Pro Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp 
    370                 375                 380                 


Cys Thr Thr Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp 
385                 390                 395                 400 


Leu Leu Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys 
                405                 410                 415     


Ile Gln Gly Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            420                 425                 430 


<210>  19
<211>  426
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-040pre LC

<400>  19

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Val Gln Met Thr Gln Ser Pro Ser Ser 
        35                  40                  45              


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Ile Asn Lys Phe Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
65                  70                  75                  80  


Ala Pro Lys Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile 
                85                  90                  95      


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Thr Phe Thr 
            100                 105                 110         


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln 
        115                 120                 125             


Tyr Gly Asn Leu Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    130                 135                 140                 


Gly Ser Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                165                 170                 175     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            180                 185                 190         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        195                 200                 205             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
    210                 215                 220                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
225                 230                 235                 240 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250                 255     


Leu Glu Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val 
            260                 265                 270         


Ala Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu 
        275                 280                 285             


Pro Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn 
    290                 295                 300                 


Ala Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His 
305                 310                 315                 320 


Ile Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His 
                325                 330                 335     


Thr Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala 
            340                 345                 350         


Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Met 
        355                 360                 365             


Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly 
    370                 375                 380                 


Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys 
385                 390                 395                 400 


Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln 
                405                 410                 415     


Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            420                 425     


<210>  20
<211>  496
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-112 LC

<400>  20

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu 
                245                 250                 255     


Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
            260                 265                 270         


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
        275                 280                 285             


Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
    290                 295                 300                 


Gly Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Glu Asp Phe 
305                 310                 315                 320 


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
                325                 330                 335     


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
            340                 345                 350         


Ala Arg Trp Asp Gly Thr Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             


Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu 
    370                 375                 380                 


Phe Ser Glu Ala Gln Leu Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
385                 390                 395                 400 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
                405                 410                 415     


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
            420                 425                 430         


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    450                 455                 460                 


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
465                 470                 475                 480 


Ser Ser Tyr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                485                 490                 495     


<210>  21
<211>  503
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-113 LC

<400>  21

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu 
                245                 250                 255     


Glu Val Lys Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
        275                 280                 285             


Trp Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
305                 310                 315                 320 


Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser Ala Arg Asn Thr Leu Tyr 
                325                 330                 335     


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly Tyr Phe Asp Val Trp Gly 
        355                 360                 365             


Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro 
    370                 375                 380                 


Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asn Ile Val Met 
385                 390                 395                 400 


Thr Gln Ser Pro Lys Ser Leu Ser Met Ser Val Gly Glu Arg Val Thr 
                405                 410                 415     


Leu Asn Cys Lys Ala Ser Glu Asn Val Lys Thr Tyr Val Ser Trp Tyr 
            420                 425                 430         


Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser 
        435                 440                 445             


Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala 
    450                 455                 460                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
465                 470                 475                 480 


Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Phe Thr Phe Gly Ala 
                485                 490                 495     


Gly Thr Lys Leu Glu Arg Lys 
            500             


<210>  22
<211>  500
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-114 LC

<400>  22

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu 
                245                 250                 255     


Glu Ile Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
        275                 280                 285             


Trp Met His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Thr Ile Tyr Pro Gly Asn Ser Glu Thr Asn Tyr Asn Pro Asn Phe 
305                 310                 315                 320 


Lys Gly Lys Ala Lys Leu Thr Ala Val Ser Ser Ala Ser Thr Ala Tyr 
                325                 330                 335     


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ser Arg Gly Glu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        355                 360                 365             


Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser 
    370                 375                 380                 


Glu Ala Gln Leu Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
385                 390                 395                 400 


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ala Ser Gln Ser 
                405                 410                 415     


Leu Val His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys 
            420                 425                 430         


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
        435                 440                 445             


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    450                 455                 460                 


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Phe Phe 
465                 470                 475                 480 


Cys Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys 
            500 


<210>  23
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pDualyx-115 LC

<400>  23

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu 
                245                 250                 255     


Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
            260                 265                 270         


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Thr Ser Gly 
        275                 280                 285             


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
    290                 295                 300                 


Met Gly Tyr Ile Thr Asn Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
305                 310                 315                 320 


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Glu Asn Gln Phe Phe 
                325                 330                 335     


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Asp Gly Gly Trp Phe His Tyr Phe Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Leu Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu 
    370                 375                 380                 


Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp Val Val Met Thr Gln 
385                 390                 395                 400 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
                405                 410                 415     


Cys Arg Ala Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
            420                 425                 430         


Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        435                 440                 445             


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
465                 470                 475                 480 


Asp Leu Gly Val Phe Phe Cys Ser Gln Ser Thr His Val Pro Phe Thr 
                485                 490                 495     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            500                 505     


<210>  24
<211>  500
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-116 LC

<400>  24

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Asp Ile Val Met Thr Gln Ser His Lys Phe 
        35                  40                  45              


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
    50                  55                  60                  


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
65                  70                  75                  80  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
                85                  90                  95      


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
            100                 105                 110         


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
        115                 120                 125             


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser 
    130                 135                 140                 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
                165                 170                 175     


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
            180                 185                 190         


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
        195                 200                 205             


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
    210                 215                 220                 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
225                 230                 235                 240 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Leu Glu 
                245                 250                 255     


Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
            260                 265                 270         


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
        275                 280                 285             


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
305                 310                 315                 320 


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Glu Asn Gln Val 
                325                 330                 335     


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
            340                 345                 350         


Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe Asp Val Trp Gly Thr Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu 
    370                 375                 380                 


Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr 
                405                 410                 415     


Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe Ile Ala Trp Tyr Gln His 
            420                 425                 430         


Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu 
        435                 440                 445             


Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp 
    450                 455                 460                 


Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Glu Ile Lys 
            500 


<210>  25
<211>  396
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-151 LC

<400>  25

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
                85                  90                  95      


Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly 
    130                 135                 140                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser 
145                 150                 155                 160 


Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln 
                165                 170                 175     


Leu Asp Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val 
            180                 185                 190         


Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr 
        195                 200                 205             


Asn Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu 
    210                 215                 220                 


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
                245                 250                 255     


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro 
            260                 265                 270         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Glu Ile 
        275                 280                 285             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    290                 295                 300                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
305                 310                 315                 320 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                325                 330                 335     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            340                 345                 350         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        355                 360                 365             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    370                 375                 380                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
385                 390                 395     


<210>  26
<211>  397
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-156 LC

<400>  26

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
                165                 170                 175     


Gln Leu Asn Ile Val Met Thr Gln Ser Pro Lys Ser Leu Ser Met Ser 
            180                 185                 190         


Val Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Glu Asn Val Lys 
        195                 200                 205             


Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu 
    210                 215                 220                 


Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
225                 230                 235                 240 


Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
                245                 250                 255     


Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr 
            260                 265                 270         


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Arg Lys Gly Ser Glu 
        275                 280                 285             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    290                 295                 300                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
305                 310                 315                 320 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                325                 330                 335     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            340                 345                 350         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        355                 360                 365             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    370                 375                 380                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
385                 390                 395         


<210>  27
<211>  394
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-161 LC

<400>  27

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
            180                 185                 190         


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
        195                 200                 205             


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
    210                 215                 220                 


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
                245                 250                 255     


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
            260                 265                 270         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Glu Ile Lys Arg 
        275                 280                 285             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    290                 295                 300                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
305                 310                 315                 320 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                325                 330                 335     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            340                 345                 350         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        355                 360                 365             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    370                 375                 380                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
385                 390                 


<210>  28
<211>  481
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-011pre HC

<400>  28

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  29
<211>  481
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-029pre HC

<400>  29

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  30
<211>  728
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-012pre HC

<400>  30

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys Leu Glu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys 
                485                 490                 495     


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
            500                 505                 510         


Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
        515                 520                 525             


Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn 
    530                 535                 540                 


Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn 
545                 550                 555                 560 


Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val 
                565                 570                 575     


Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp 
            580                 585                 590         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly 
        595                 600                 605             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp Ile Val 
    610                 615                 620                 


Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val 
625                 630                 635                 640 


Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp 
                645                 650                 655     


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
            660                 665                 670         


Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
        675                 680                 685             


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu 
    690                 695                 700                 


Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly 
705                 710                 715                 720 


Gly Gly Thr Lys Leu Glu Ile Lys 
                725             


<210>  31
<211>  269
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-019pre HC

<400>  31

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            260                 265                 


<210>  32
<211>  265
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-020pre HC

<400>  32

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Val Gln Leu 
            20                  25                  30          


Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr 
65                  70                  75                  80  


Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr 
        115                 120                 125             


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265 


<210>  33
<211>  530
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-044 HC

<400>  33

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Leu Glu Asp 
                485                 490                 495     


Ile Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser 
            500                 505                 510         


Arg Leu Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly 
        515                 520                 525             


Thr Gly 
    530 


<210>  34
<211>  491
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-118 HC

<400>  34

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Arg Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Gly Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Tyr Leu Ser Leu Ser Pro Gly Lys 
                485                 490     


<210>  35
<211>  780
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-119 HC

<400>  35

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Leu Glu Asp 
                485                 490                 495     


Ile Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser 
            500                 505                 510         


Arg Leu Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly 
        515                 520                 525             


Thr Gly Gly Gly Ser Val Glu Gln Val Gln Leu Leu Gln Ser Gly Pro 
    530                 535                 540                 


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
545                 550                 555                 560 


Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro 
                565                 570                 575     


Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp 
            580                 585                 590         


Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp 
        595                 600                 605             


Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu 
    610                 615                 620                 


Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr 
625                 630                 635                 640 


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser 
                645                 650                 655     


Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln 
            660                 665                 670         


Leu Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val 
        675                 680                 685             


Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr 
    690                 695                 700                 


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
705                 710                 715                 720 


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr 
                725                 730                 735     


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln 
            740                 745                 750         


Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro 
        755                 760                 765             


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    770                 775                 780 


<210>  36
<211>  617
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-021 HC

<400>  36

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
            180                 185                 190         


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
        195                 200                 205             


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
                245                 250                 255     


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    290                 295                 300                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        355                 360                 365             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    370                 375                 380                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210>  37
<211>  864
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-024 HC

<400>  37

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
            180                 185                 190         


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
        195                 200                 205             


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
                245                 250                 255     


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    290                 295                 300                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        355                 360                 365             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    370                 375                 380                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Gln Val Gln Leu Leu 
    610                 615                 620                 


Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
625                 630                 635                 640 


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val 
                645                 650                 655     


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro 
            660                 665                 670         


Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile 
        675                 680                 685             


Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser 
    690                 695                 700                 


Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly 
705                 710                 715                 720 


Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val 
                725                 730                 735     


Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe 
            740                 745                 750         


Ser Glu Ala Gln Leu Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
        755                 760                 765             


Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln 
    770                 775                 780                 


Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
785                 790                 795                 800 


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
                805                 810                 815     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
            820                 825                 830         


Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr 
        835                 840                 845             


Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    850                 855                 860                 


<210>  38
<211>  654
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-051 HC

<400>  38

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
            180                 185                 190         


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
        195                 200                 205             


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
                245                 250                 255     


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
            260                 265                 270         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Ser Ser Ala 
        275                 280                 285             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    290                 295                 300                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
305                 310                 315                 320 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                325                 330                 335     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            340                 345                 350         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        355                 360                 365             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    370                 375                 380                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile Ala Cys Gly 
    610                 615                 620                 


Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg Leu Glu Glu 
625                 630                 635                 640 


Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly Thr Gly 
                645                 650                 


<210>  39
<211>  741
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-080 HC

<400>  39

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Leu Glu Gln 
                485                 490                 495     


Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu Thr 
            500                 505                 510         


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile His Gly 
        515                 520                 525             


Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
    530                 535                 540                 


Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asn Asp Phe Lys 
545                 550                 555                 560 


Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
                565                 570                 575     


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            580                 585                 590         


Arg Asp Glu Val Arg Arg Gly Phe Gly Phe Ala Tyr Trp Gly Gln Gly 
        595                 600                 605             


Thr Leu Val Thr Val Ser Ala Arg Ser Ser Thr Lys Gly Pro Lys Leu 
    610                 615                 620                 


Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp Ile Val Met Ala Gln 
625                 630                 635                 640 


Ser Gln Lys Phe Met Ser Val Ser Val Gly Asp Arg Val Ser Val Thr 
                645                 650                 655     


Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln 
            660                 665                 670         


Arg Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg 
        675                 680                 685             


Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr 
705                 710                 715                 720 


Phe Cys Gln Gln Phe Asp Ser His Pro Leu Thr Phe Gly Ala Gly Thr 
                725                 730                 735     


Lys Leu Glu Leu Lys 
            740     


<210>  40
<211>  742
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-082 HC

<400>  40

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Leu Glu Glu 
                485                 490                 495     


Val Lys Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            500                 505                 510         


Leu Lys Leu Ser Cys Glu Ala Ser Gly Ile Asp Phe Ser Arg Tyr Trp 
        515                 520                 525             


Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Glu Ser Asp Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
545                 550                 555                 560 


Asp Lys Phe Ile Ile Ser Arg Asp Ser Ala Arg Asn Thr Leu Tyr Leu 
                565                 570                 575     


Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
            580                 585                 590         


Arg Glu Gly Tyr Tyr Asp Asn Glu Gly Tyr Phe Asp Val Trp Gly Thr 
        595                 600                 605             


Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys 
    610                 615                 620                 


Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asn Ile Val Met Thr 
625                 630                 635                 640 


Gln Ser Pro Lys Ser Leu Ser Met Ser Val Gly Glu Arg Val Thr Leu 
                645                 650                 655     


Asn Cys Lys Ala Ser Glu Asn Val Lys Thr Tyr Val Ser Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
        675                 680                 685             


Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr 
    690                 695                 700                 


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp 
705                 710                 715                 720 


Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Phe Thr Phe Gly Ala Gly 
                725                 730                 735     


Thr Lys Leu Glu Arg Lys 
            740         


<210>  41
<211>  739
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-063 HC

<400>  41

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Leu Gln Val Gln Leu Leu Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr 
                85                  90                  95      


Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr 
            100                 105                 110         


Ser Ser Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu Phe Leu Glu Gln 
                485                 490                 495     


Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr 
            500                 505                 510         


Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe Gly 
        515                 520                 525             


Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp 
    530                 535                 540                 


Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu 
545                 550                 555                 560 


Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Glu Asn Gln Val Phe 
                565                 570                 575     


Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Val Arg Ile Ala Gly Thr Arg Tyr Phe Asp Val Trp Gly Thr Gly Thr 
        595                 600                 605             


Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu 
    610                 615                 620                 


Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys 
                645                 650                 655     


Lys Ala Ser Gln Asp Ile Asn Lys Phe Ile Ala Trp Tyr Gln His Lys 
            660                 665                 670         


Pro Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln 
        675                 680                 685             


Pro Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr 
    690                 695                 700                 


Ser Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr 
705                 710                 715                 720 


Cys Leu Gln Tyr Asp Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Glu Ile Lys 
            


<210>  42
<211>  486
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-006 HC

<400>  42

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
                85                  90                  95      


Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly 
    130                 135                 140                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser 
145                 150                 155                 160 


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
                165                 170                 175     


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
            180                 185                 190         


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
        195                 200                 205             


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
    210                 215                 220                 


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln 
225                 230                 235                 240 


Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
            260                 265                 270         


Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Ala 
    290                 295                 300                 


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
305                 310                 315                 320 


Val Glu Val His Thr Ala Gln Thr Lys Pro Arg Glu Glu Gln Ile Asn 
                325                 330                 335     


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
    370                 375                 380                 


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
385                 390                 395                 400 


Lys Val Ser Leu Thr Cys Met Ile Thr Asn Phe Phe Pro Glu Asp Ile 
                405                 410                 415     


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
            420                 425                 430         


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
        435                 440                 445             


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
    450                 455                 460                 


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
465                 470                 475                 480 


Ser His Ser Pro Gly Lys 
                485     


<210>  43
<211>  482
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-031 HC

<400>  43

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Ile Gln Leu 
            20                  25                  30          


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu Thr Val Lys Ile 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile His Gly Met Ser Trp 
    50                  55                  60                  


Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn 
65                  70                  75                  80  


Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe 
                85                  90                  95      


Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn 
            100                 105                 110         


Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu 
        115                 120                 125             


Val Arg Arg Gly Phe Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ala Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  44
<211>  493
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-091 HC

<400>  44

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                165                 170                 175     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            180                 185                 190         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        195                 200                 205             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    210                 215                 220                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
225                 230                 235                 240 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                245                 250                 255     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490             


<210>  45
<211>  491
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-075 HC

<400>  45

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490     


<210>  46
<211>  730
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-017pre HC

<400>  46

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Gln Ile Gln Leu 
            20                  25                  30          


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu Thr Val Lys Ile 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile His Gly Met Ser Trp 
    50                  55                  60                  


Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn 
65                  70                  75                  80  


Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe 
                85                  90                  95      


Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn 
            100                 105                 110         


Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu 
        115                 120                 125             


Val Arg Arg Gly Phe Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ala Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
145                 150                 155                 160 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                165                 170                 175     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            180                 185                 190         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        195                 200                 205             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    210                 215                 220                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
225                 230                 235                 240 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
                485                 490                 495     


Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
            500                 505                 510         


Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly 
        515                 520                 525             


Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr 
    530                 535                 540                 


Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala 
545                 550                 555                 560 


Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala 
                565                 570                 575     


Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly Phe Ala 
            580                 585                 590         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser Ser Thr 
        595                 600                 605             


Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asp 
    610                 615                 620                 


Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val Gly Asp 
625                 630                 635                 640 


Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val 
                645                 650                 655     


Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu Ile Tyr 
            660                 665                 670         


Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser 
        675                 680                 685             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu 
    690                 695                 700                 


Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro Leu Thr 
705                 710                 715                 720 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                725                 730 


<210>  47
<211>  742
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-108 HC

<400>  47

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                165                 170                 175     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            180                 185                 190         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        195                 200                 205             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    210                 215                 220                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
225                 230                 235                 240 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                245                 250                 255     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Glu 
                485                 490                 495     


Val Lys Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            500                 505                 510         


Leu Lys Leu Ser Cys Glu Ala Ser Gly Ile Asp Phe Ser Arg Tyr Trp 
        515                 520                 525             


Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Glu Ser Asp Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
545                 550                 555                 560 


Asp Lys Phe Ile Ile Ser Arg Asp Ser Ala Arg Asn Thr Leu Tyr Leu 
                565                 570                 575     


Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
            580                 585                 590         


Arg Glu Gly Tyr Tyr Asp Asn Glu Gly Tyr Phe Asp Val Trp Gly Thr 
        595                 600                 605             


Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys 
    610                 615                 620                 


Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu Asn Ile Val Met Thr 
625                 630                 635                 640 


Gln Ser Pro Lys Ser Leu Ser Met Ser Val Gly Glu Arg Val Thr Leu 
                645                 650                 655     


Asn Cys Lys Ala Ser Glu Asn Val Lys Thr Tyr Val Ser Trp Tyr Gln 
            660                 665                 670         


Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
        675                 680                 685             


Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Ala Thr 
    690                 695                 700                 


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp 
705                 710                 715                 720 


Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Phe Thr Phe Gly Ala Gly 
                725                 730                 735     


Thr Lys Leu Glu Arg Lys 
            740         


<210>  48
<211>  737
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-111 HC

<400>  48

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Gln Val Thr 
                485                 490                 495     


Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser 
            500                 505                 510         


Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe Gly Met Gly 
        515                 520                 525             


Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala 
    530                 535                 540                 


His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
545                 550                 555                 560 


Arg Leu Thr Ile Ser Lys Asp Thr Ser Glu Asn Gln Val Phe Leu Lys 
                565                 570                 575     


Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys Val Arg 
            580                 585                 590         


Ile Ala Gly Thr Arg Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Arg Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly 
    610                 615                 620                 


Glu Phe Ser Glu Ala Gln Leu Asp Ile Gln Met Thr Gln Ser Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ala 
                645                 650                 655     


Ser Gln Asp Ile Asn Lys Phe Ile Ala Trp Tyr Gln His Lys Pro Gly 
            660                 665                 670         


Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly 
        675                 680                 685             


Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe 
    690                 695                 700                 


Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu 
705                 710                 715                 720 


Gln Tyr Asp Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
                725                 730                 735     


Lys 
    


<210>  49
<211>  481
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-027 HC

<400>  49

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Glu Val Gln Leu 
            20                  25                  30          


Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu 
        35                  40                  45              


Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp Tyr Ile His Trp 
    50                  55                  60                  


Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp 
65                  70                  75                  80  


Pro Glu Asn Ser Asp Thr Glu Tyr Ala Ser Lys Phe Gln Gly Lys Ala 
                85                  90                  95      


Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr Gly Leu 
        115                 120                 125             


Trp Leu Arg Thr Ala Ile Asp Tyr Trp Gly Gln Gly Thr Ser Ile Thr 
    130                 135                 140                 


Val Ser Ser Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  50
<211>  487
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-085 HC

<400>  50

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Thr Ala Gly Met Gln Trp Val Gln Lys Met Pro Gly 
65                  70                  75                  80  


Lys Gly Phe Lys Trp Ile Gly Trp Ile Asn Thr His Ser Gly Glu Pro 
                85                  90                  95      


Lys Tyr Ala Glu Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Trp Asp Gly Thr Gly Tyr Trp Gly 
    130                 135                 140                 


Gln Gly Thr Thr Leu Thr Val Ser Ser Arg Ser Ser Ser Ala Ser Thr 
145                 150                 155                 160 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                165                 170                 175     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            180                 185                 190         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        195                 200                 205             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    210                 215                 220                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
225                 230                 235                 240 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                245                 250                 255     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        275                 280                 285             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    290                 295                 300                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
305                 310                 315                 320 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                325                 330                 335     


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            340                 345                 350         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        355                 360                 365             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    370                 375                 380                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
385                 390                 395                 400 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                405                 410                 415     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            420                 425                 430         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        435                 440                 445             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    450                 455                 460                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
465                 470                 475                 480 


Leu Ser Leu Ser Pro Gly Lys 
                485         


<210>  51
<211>  485
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-088 HC

<400>  51

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Ile Gln Leu Gln Gln Ser Gly Thr Val 
        35                  40                  45              


Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Asn Tyr Trp Met His Trp Leu Lys Gln Arg Pro Gly 
65                  70                  75                  80  


Gln Gly Leu Glu Trp Ile Gly Thr Ile Tyr Pro Gly Asn Ser Glu Thr 
                85                  90                  95      


Asn Tyr Asn Pro Asn Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Asn Glu Asp 
        115                 120                 125             


Ser Ala Val Tyr Tyr Cys Ser Arg Gly Glu Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Ser Val Thr Val Ser Ser Arg Ser Ser Ser Ala Ser Thr Lys Gly 
145                 150                 155                 160 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
                165                 170                 175     


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            180                 185                 190         


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        195                 200                 205             


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    210                 215                 220                 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
225                 230                 235                 240 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
                245                 250                 255     


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            260                 265                 270         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        275                 280                 285             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    290                 295                 300                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
305                 310                 315                 320 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
                325                 330                 335     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            340                 345                 350         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        355                 360                 365             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    370                 375                 380                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
385                 390                 395                 400 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                405                 410                 415     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            420                 425                 430         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    450                 455                 460                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
465                 470                 475                 480 


Leu Ser Pro Gly Lys 
                485 


<210>  52
<211>  491
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-069 HC

<400>  52

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Asp Val Gln Leu Gln Glu Ser Gly Pro Gly 
        35                  40                  45              


Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly 
    50                  55                  60                  


Ser Ser Ile Thr Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro 
65                  70                  75                  80  


Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Thr Asn Asp Gly Ser Asn 
                85                  90                  95      


Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr 
            100                 105                 110         


Ser Glu Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Ala Arg Asp Gly Gly Trp Phe His Tyr Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490     


<210>  53
<211>  491
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-041pre HC

<400>  53

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Ala 
        35                  40                  45              


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Pro Gly Lys Ala Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Phe Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Leu Thr Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490     


<210>  54
<211>  529
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-149 HC

<400>  54

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
                85                  90                  95      


Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly 
    130                 135                 140                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser 
145                 150                 155                 160 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                165                 170                 175     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            180                 185                 190         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        195                 200                 205             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    210                 215                 220                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
225                 230                 235                 240 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                245                 250                 255     


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile 
                485                 490                 495     


Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg 
            500                 505                 510         


Leu Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly Thr 
        515                 520                 525             


Gly 
    


<210>  55
<211>  618
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-150 HC

<400>  55

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
                85                  90                  95      


Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly 
    130                 135                 140                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser 
145                 150                 155                 160 


Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln 
                165                 170                 175     


Leu Asp Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val 
            180                 185                 190         


Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr 
        195                 200                 205             


Asn Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu 
    210                 215                 220                 


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
                245                 250                 255     


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro 
            260                 265                 270         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Ser Ser 
        275                 280                 285             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    290                 295                 300                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
305                 310                 315                 320 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                325                 330                 335     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            340                 345                 350         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        355                 360                 365             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    370                 375                 380                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                405                 410                 415     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            420                 425                 430         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        435                 440                 445             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    450                 455                 460                 


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
465                 470                 475                 480 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                485                 490                 495     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            500                 505                 510         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        515                 520                 525             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    530                 535                 540                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
545                 550                 555                 560 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                565                 570                 575     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            580                 585                 590         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        595                 600                 605             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615             


<210>  56
<211>  655
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-152 HC

<400>  56

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
                85                  90                  95      


Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly 
    130                 135                 140                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser 
145                 150                 155                 160 


Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln 
                165                 170                 175     


Leu Asp Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val 
            180                 185                 190         


Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr 
        195                 200                 205             


Asn Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu 
    210                 215                 220                 


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
                245                 250                 255     


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro 
            260                 265                 270         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Ser Ser 
        275                 280                 285             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    290                 295                 300                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
305                 310                 315                 320 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                325                 330                 335     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            340                 345                 350         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        355                 360                 365             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    370                 375                 380                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                405                 410                 415     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            420                 425                 430         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        435                 440                 445             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    450                 455                 460                 


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
465                 470                 475                 480 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                485                 490                 495     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            500                 505                 510         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        515                 520                 525             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    530                 535                 540                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
545                 550                 555                 560 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                565                 570                 575     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            580                 585                 590         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        595                 600                 605             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile Ala Cys 
    610                 615                 620                 


Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg Leu Glu 
625                 630                 635                 640 


Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly Thr Gly 
                645                 650                 655 


<210>  57
<211>  439
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx1-153 HC

<400>  57

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
        35                  40                  45              


Val Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
    50                  55                  60                  


Tyr Thr Phe Thr Ile His Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
                85                  90                  95      


Thr Tyr Ala Asn Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
            100                 105                 110         


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu Val Arg Arg Gly Phe Gly 
    130                 135                 140                 


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Arg Ser 
145                 150                 155                 160 


Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln 
                165                 170                 175     


Leu Asp Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val 
            180                 185                 190         


Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr 
        195                 200                 205             


Asn Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu 
    210                 215                 220                 


Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln 
                245                 250                 255     


Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro 
            260                 265                 270         


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Ser Ser 
        275                 280                 285             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    290                 295                 300                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
305                 310                 315                 320 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                325                 330                 335     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            340                 345                 350         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        355                 360                 365             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    370                 375                 380                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
385                 390                 395                 400 


Pro Ala Leu Glu Asp Ile Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile 
                405                 410                 415     


Lys Asp Leu Leu Ser Arg Leu Glu Glu Leu Glu Gly Leu Val Ser Ser 
            420                 425                 430         


Leu Arg Glu Gln Gly Thr Gly 
        435                 


<210>  58
<211>  530
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-154 HC

<400>  58

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                165                 170                 175     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            180                 185                 190         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        195                 200                 205             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    210                 215                 220                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
225                 230                 235                 240 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                245                 250                 255     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp 
                485                 490                 495     


Ile Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser 
            500                 505                 510         


Arg Leu Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly 
        515                 520                 525             


Thr Gly 
    530 


<210>  59
<211>  619
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-155 HC

<400>  59

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
                165                 170                 175     


Gln Leu Asn Ile Val Met Thr Gln Ser Pro Lys Ser Leu Ser Met Ser 
            180                 185                 190         


Val Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Glu Asn Val Lys 
        195                 200                 205             


Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu 
    210                 215                 220                 


Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
225                 230                 235                 240 


Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
                245                 250                 255     


Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr 
            260                 265                 270         


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Arg Lys Gly Ser Ser 
        275                 280                 285             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    290                 295                 300                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
305                 310                 315                 320 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                325                 330                 335     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            340                 345                 350         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        355                 360                 365             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    370                 375                 380                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                405                 410                 415     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            420                 425                 430         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        435                 440                 445             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    450                 455                 460                 


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
465                 470                 475                 480 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                485                 490                 495     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            500                 505                 510         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        515                 520                 525             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    530                 535                 540                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
545                 550                 555                 560 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                565                 570                 575     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            580                 585                 590         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        595                 600                 605             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 


<210>  60
<211>  656
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-157 HC

<400>  60

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
                165                 170                 175     


Gln Leu Asn Ile Val Met Thr Gln Ser Pro Lys Ser Leu Ser Met Ser 
            180                 185                 190         


Val Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Glu Asn Val Lys 
        195                 200                 205             


Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu 
    210                 215                 220                 


Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
225                 230                 235                 240 


Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
                245                 250                 255     


Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr 
            260                 265                 270         


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Arg Lys Gly Ser Ser 
        275                 280                 285             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    290                 295                 300                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
305                 310                 315                 320 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                325                 330                 335     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            340                 345                 350         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        355                 360                 365             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    370                 375                 380                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                405                 410                 415     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            420                 425                 430         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        435                 440                 445             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    450                 455                 460                 


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
465                 470                 475                 480 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                485                 490                 495     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            500                 505                 510         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        515                 520                 525             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    530                 535                 540                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
545                 550                 555                 560 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                565                 570                 575     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            580                 585                 590         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        595                 600                 605             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile Ala 
    610                 615                 620                 


Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg Leu 
625                 630                 635                 640 


Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly Thr Gly 
                645                 650                 655     


<210>  61
<211>  440
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-158 HC

<400>  61

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Glu Val Lys Leu Leu Gln Ser Gly Gly Gly 
        35                  40                  45              


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly 
    50                  55                  60                  


Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly 
65                  70                  75                  80  


Lys Gly Leu Glu Trp Ile Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile 
                85                  90                  95      


Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser 
            100                 105                 110         


Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp 
        115                 120                 125             


Thr Ala Leu Tyr Tyr Cys Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly 
    130                 135                 140                 


Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg 
145                 150                 155                 160 


Ser Ser Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
                165                 170                 175     


Gln Leu Asn Ile Val Met Thr Gln Ser Pro Lys Ser Leu Ser Met Ser 
            180                 185                 190         


Val Gly Glu Arg Val Thr Leu Asn Cys Lys Ala Ser Glu Asn Val Lys 
        195                 200                 205             


Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu 
    210                 215                 220                 


Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe 
225                 230                 235                 240 


Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 
                245                 250                 255     


Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr 
            260                 265                 270         


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Arg Lys Gly Ser Ser 
        275                 280                 285             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    290                 295                 300                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
305                 310                 315                 320 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                325                 330                 335     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            340                 345                 350         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        355                 360                 365             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    370                 375                 380                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 


Cys Pro Ala Leu Glu Asp Ile Ala Cys Gly Cys Ala Ala Ala Pro Asp 
                405                 410                 415     


Ile Lys Asp Leu Leu Ser Arg Leu Glu Glu Leu Glu Gly Leu Val Ser 
            420                 425                 430         


Ser Leu Arg Glu Gln Gly Thr Gly 
        435                 440 


<210>  62
<211>  528
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-159 HC

<400>  62

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                165                 170                 175     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            180                 185                 190         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        195                 200                 205             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
225                 230                 235                 240 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                245                 250                 255     


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile Ala 
                485                 490                 495     


Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg Leu 
            500                 505                 510         


Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly Thr Gly 
        515                 520                 525             


<210>  63
<211>  616
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-160 HC

<400>  63

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
            180                 185                 190         


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
        195                 200                 205             


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
    210                 215                 220                 


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
                245                 250                 255     


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
            260                 265                 270         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Ser Ser Ala Ser 
        275                 280                 285             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    290                 295                 300                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
305                 310                 315                 320 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                325                 330                 335     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            340                 345                 350         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        355                 360                 365             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    370                 375                 380                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615     


<210>  64
<211>  653
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-162 HC

<400>  64

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
            180                 185                 190         


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
        195                 200                 205             


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
    210                 215                 220                 


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
                245                 250                 255     


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
            260                 265                 270         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Ser Ser Ala Ser 
        275                 280                 285             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    290                 295                 300                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
305                 310                 315                 320 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                325                 330                 335     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            340                 345                 350         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        355                 360                 365             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    370                 375                 380                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro Gly Lys Leu Glu Asp Ile Ala Cys Gly Cys 
    610                 615                 620                 


Ala Ala Ala Pro Asp Ile Lys Asp Leu Leu Ser Arg Leu Glu Glu Leu 
625                 630                 635                 640 


Glu Gly Leu Val Ser Ser Leu Arg Glu Gln Gly Thr Gly 
                645                 650             


<210>  65
<211>  437
<212>  PRT
<213>  artificial sequence

<220>
<223>  pDualyx-163 HC

<400>  65

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gln Leu Asp Tyr Lys Asp 
            20                  25                  30          


Asp Asp Asp Lys Glu Phe Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
        35                  40                  45              


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
    50                  55                  60                  


Phe Ser Leu Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
65                  70                  75                  80  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
                85                  90                  95      


Lys Tyr Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
            100                 105                 110         


Thr Ser Glu Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe 
    130                 135                 140                 


Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Arg Ser Ser 
145                 150                 155                 160 


Thr Lys Gly Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Gln Leu 
                165                 170                 175     


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
            180                 185                 190         


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
        195                 200                 205             


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
    210                 215                 220                 


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
225                 230                 235                 240 


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
                245                 250                 255     


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
            260                 265                 270         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Ser Ser Ala Ser 
        275                 280                 285             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    290                 295                 300                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
305                 310                 315                 320 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                325                 330                 335     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            340                 345                 350         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        355                 360                 365             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    370                 375                 380                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Leu Glu Asp Ile Ala Cys Gly Cys Ala Ala Ala Pro Asp Ile Lys Asp 
                405                 410                 415     


Leu Leu Ser Arg Leu Glu Glu Leu Glu Gly Leu Val Ser Ser Leu Arg 
            420                 425                 430         


Glu Gln Gly Thr Gly 
        435         


<210>  66
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VL CDR1

<400>  66

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Gly Thr 
1               5                   10                  15      


Asn Asn Arg Thr Pro 
            20      


<210>  67
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VL CDR2

<400>  67

Gly Thr Asn Asn Arg Thr Pro 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VL CDR3

<400>  68

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  69
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VL CDR1

<400>  69

Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala 
1               5                   10      


<210>  70
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VL CDR2

<400>  70

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VL CDR3

<400>  71

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  72
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VL CDR1

<400>  72

Lys Ala Ser Gln Asp Val Asp Thr Ala Val 
1               5                   10  


<210>  73
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VL CDR2

<400>  73

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VL CDR3

<400>  74

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  75
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VL CDR1

<400>  75

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  76
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VL CDR2

<400>  76

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VL CDR3

<400>  77

Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  78
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VL CDR1

<400>  78

Arg Ala Ser Glu Asn Ile Asp Asn Tyr Gly Ile Ser Phe Met Tyr 
1               5                   10                  15  


<210>  79
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VL CDR2

<400>  79

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VL CDR3

<400>  80

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  81
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VL CDR1

<400>  81

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  82
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VL CDR2

<400>  82

Ser Ala Ser Phe Arg Tyr Ser 
1               5           


<210>  83
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VL CDR3

<400>  83

Gln His Phe Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  84
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VL CDR1

<400>  84

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  85
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VL CDR2

<400>  85

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  86
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VL CDR3

<400>  86

Gln Gln Phe Asp Ser His Pro Leu Thr 
1               5                   


<210>  87
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VL CDR1

<400>  87

Lys Ala Ser Gln Asn Val Gly Ser Asn Val Asp 
1               5                   10      


<210>  88
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VL CDR2

<400>  88

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  89
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VL CDR3

<400>  89

Gln Gln Tyr Asn Ser His Pro Leu Thr 
1               5                   


<210>  90
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-1 VL CDR1

<400>  90

Arg Ala Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Gln 
1               5                   10                  15      


<210>  91
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-1 VL CDR2

<400>  91

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  92
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-1 VL CDR3

<400>  92

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  93
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-2 VL CDR1

<400>  93

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  94
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-2 VL CDR2

<400>  94

Thr Asn Asn Arg Ala Pro 
1               5       


<210>  95
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-2 VL CDR3

<400>  95

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  96
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VL CDR1

<400>  96

Lys Ala Ser Gln Asp Ile Asn Lys Phe Ile Ala 
1               5                   10      


<210>  97
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VL CDR2

<400>  97

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  98
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VL CDR3

<400>  98

Leu Gln Tyr Asp Asn Leu Tyr Thr 
1               5               


<210>  99
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VH CDR1

<400>  99

Asp Asp Tyr Ile His 
1               5   


<210>  100
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VH CDR2

<400>  100

Trp Ile Asp Pro Glu Asn Ser Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly Lys Ala Thr 
            20  


<210>  101
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VH CDR3

<400>  101

Thr Thr Gly Leu Trp Leu Arg Thr Ala Ile Asp Tyr 
1               5                   10          


<210>  102
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VH CDR1

<400>  102

Ser Tyr Asp Ile Asn 
1               5   


<210>  103
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VH CDR2

<400>  103

Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly Lys Ala Ile 
            20  


<210>  104
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VH CDR3

<400>  104

Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  105
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VH CDR1

<400>  105

Asp Asp Tyr Ile His 
1               5   


<210>  106
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VH CDR2

<400>  106

Trp Ile Asp Pro Glu Asn Ser Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly Lys Ala Thr 
            20  


<210>  107
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VH CDR3

<400>  107

Gly Leu Trp Leu Arg Thr Ala Ile Asp Tyr 
1               5                   10  


<210>  108
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VH CDR1

<400>  108

Thr Ala Gly Met Gln 
1               5   


<210>  109
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VH CDR2

<400>  109

Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly Arg Phe Ala 
            20  


<210>  110
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VH CDR3

<400>  110

Trp Asp Gly Thr Gly Tyr 
1               5       


<210>  111
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VH CDR1

<400>  111

Asp Tyr Glu Met His 
1               5   


<210>  112
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VH CDR2

<400>  112

Val Val Asp Pro Gly Thr Gly Asp Thr Ala Ser Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VH CDR3

<400>  113

Arg Tyr Tyr Gly Ser Arg Glu Ser Met Asp Tyr 
1               5                   10      


<210>  114
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VH CDR1

<400>  114

Arg Tyr Trp Met Ser 
1               5   


<210>  115
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VH CDR2

<400>  115

Glu Ser Asp Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
1               5                   10                  15      


Asp Lys Phe Ile 
            20  


<210>  116
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VH CDR3

<400>  116

Glu Gly Tyr Tyr Asp Asn Glu Gly Tyr Phe Asp Val 
1               5                   10          


<210>  117
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VH CDR1

<400>  117

Ile His Gly Met Ser 
1               5   


<210>  118
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VH CDR2

<400>  118

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asn Asp Phe Lys 
1               5                   10                  15      


Gly Arg Phe Ala 
            20  


<210>  119
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VH CDR3

<400>  119

Ala Arg Asp Glu Val Arg Arg Gly Phe Gly Phe Ala Tyr 
1               5                   10              


<210>  120
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VH CDR1

<400>  120

Asp Leu Tyr Ile His 
1               5   


<210>  121
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VH CDR2

<400>  121

Trp Ile Asp Pro Glu Thr Asp Asn Thr Ile Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly Lys Ala Ser 
            20  


<210>  122
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VH CDR3

<400>  122

Ser Thr Gly Leu Leu Gln Trp Tyr Phe Asp Val 
1               5                   10      


<210>  123
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH CDR1

<400>  123

Gly Tyr Tyr Trp Asn 
1               5   


<210>  124
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH CDR2

<400>  124

Tyr Ile Thr Asn Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


Arg Ile Ser 
            


<210>  125
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH CDR3

<400>  125

Asp Gly Gly Trp Phe His Tyr Phe Asp Tyr 
1               5                   10  


<210>  126
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH CDR1

<400>  126

Gly Tyr Tyr Trp Asn 
1               5   


<210>  127
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH CDR2

<400>  127

Tyr Ile Thr Asn Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


Arg Ile Ser 
            


<210>  128
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH CDR3

<400>  128

Asp Gly Gly Trp Phe His Tyr Phe Asp Tyr 
1               5                   10  


<210>  129
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VH CDR1

<400>  129

Gly Met Gly Val Gly 
1               5   


<210>  130
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VH CDR2

<400>  130

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


Arg Leu Thr 
            


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C40 VH CDR3

<400>  131

Ile Ala Gly Thr Arg Tyr Phe Asp Val 
1               5                   


<210>  132
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  133
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  134
<211>  559
<212>  PRT
<213>  artificial sequence

<220>
<223>  TNC-sc(mu)TNF(143N/145R)

<400>  134

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gly Ser Gly Ser Asp Tyr 
            20                  25                  30          


Lys Asp Asp Asp Asp Lys Asp Ile Ala Cys Gly Cys Ala Ala Ala Pro 
        35                  40                  45              


Asp Ile Lys Asp Leu Leu Ser Arg Leu Glu Glu Leu Glu Gly Leu Val 
    50                  55                  60                  


Ser Ser Leu Arg Glu Gln Gly Thr Gly Gly Gly Ser Gly Gly Arg Gly 
65                  70                  75                  80  


Glu Phe Glu Phe Thr Arg Asp Lys Pro Val Ala His Val Val Ala Asn 
                85                  90                  95      


His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala 
            100                 105                 110         


Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro 
        115                 120                 125             


Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    130                 135                 140                 


Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala 
145                 150                 155                 160 


Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro 
                165                 170                 175     


Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu 
        195                 200                 205             


Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Val Ile Ala Leu Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Lys Pro Val Ala His Val 
                245                 250                 255     


Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
            260                 265                 270         


Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu 
        275                 280                 285             


Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe 
    290                 295                 300                 


Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser 
305                 310                 315                 320 


Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val 
                325                 330                 335     


Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro 
            340                 345                 350         


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
        355                 360                 365             


Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg 
    370                 375                 380                 


Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Lys Pro Val 
                405                 410                 415     


Ala His Val Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu 
            420                 425                 430         


Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp 
        435                 440                 445             


Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln 
    450                 455                 460                 


Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His 
465                 470                 475                 480 


Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu 
                485                 490                 495     


Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu 
            500                 505                 510         


Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu 
        515                 520                 525             


Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu 
    530                 535                 540                 


Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
545                 550                 555                 


<210>  135
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  full Durv heavy chain constant region sequences with CH1

<400>  135

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  136
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  full Durv light chain constant region sequences with CH1 deletion

<400>  136

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  137
<211>  474
<212>  PRT
<213>  artificial sequence

<220>
<223>  TNFR2(mu)-pCMV-SPORT6 (Tnfrsf1b) (Origene) cDNA clone

<400>  137

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Phe Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Gln Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Lys Pro Glu Pro Gly Tyr Glu Cys Gln Ile Ser Gln Glu Tyr Tyr Asp 
        35                  40                  45              


Arg Lys Ala Gln Met Cys Cys Ala Lys Cys Pro Pro Gly Gln Tyr Val 
    50                  55                  60                  


Lys His Phe Cys Asn Lys Thr Ser Asp Thr Val Cys Ala Asp Cys Glu 
65                  70                  75                  80  


Ala Ser Met Tyr Thr Gln Val Trp Asn Gln Phe Arg Thr Cys Leu Ser 
                85                  90                  95      


Cys Ser Ser Ser Cys Thr Thr Asp Gln Val Glu Ile Arg Ala Cys Thr 
            100                 105                 110         


Lys Gln Gln Asn Arg Val Cys Ala Cys Glu Ala Gly Arg Tyr Cys Ala 
        115                 120                 125             


Leu Lys Thr His Ser Gly Ser Cys Arg Gln Cys Met Arg Leu Ser Lys 
    130                 135                 140                 


Cys Gly Pro Gly Phe Gly Val Ala Ser Ser Arg Ala Pro Asn Gly Asn 
145                 150                 155                 160 


Val Leu Cys Lys Ala Cys Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser 
                165                 170                 175     


Ser Thr Asp Val Cys Arg Pro His Arg Ile Cys Ser Ile Leu Ala Ile 
            180                 185                 190         


Pro Gly Asn Ala Ser Thr Asp Ala Val Cys Ala Pro Glu Ser Pro Thr 
        195                 200                 205             


Leu Ser Ala Ile Pro Arg Thr Leu Tyr Val Ser Gln Pro Glu Pro Thr 
    210                 215                 220                 


Arg Ser Gln Pro Leu Asp Gln Glu Pro Gly Pro Ser Gln Thr Pro Ser 
225                 230                 235                 240 


Ile Leu Thr Ser Leu Gly Ser Thr Pro Ile Ile Glu Gln Ser Thr Lys 
                245                 250                 255     


Gly Gly Ile Ser Leu Pro Ile Gly Leu Ile Val Gly Val Thr Ser Leu 
            260                 265                 270         


Gly Leu Leu Met Leu Gly Leu Val Asn Cys Ile Ile Leu Val Gln Arg 
        275                 280                 285             


Lys Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val 
    290                 295                 300                 


Pro Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu 
305                 310                 315                 320 


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
                325                 330                 335     


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
            340                 345                 350         


Val Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg 
        355                 360                 365             


Ile Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
    370                 375                 380                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
385                 390                 395                 400 


Ser Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala 
                405                 410                 415     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
            420                 425                 430         


Gln Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly 
    450                 455                 460                 


Trp Phe Asp Gln Ile Ala Val Lys Val Ala 
465                 470                 


<210>  138
<211>  445
<212>  PRT
<213>  Macaca fascicularis

<400>  138

Met Ala Val Phe Pro Ser Ser Phe Gln Val Ala Phe Thr Pro Tyr Ala 
1               5                   10                  15      


Pro Glu Pro Gly Gly Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr 
            20                  25                  30          


Ala Gln Met Cys Cys Ser Lys Cys Pro Pro Gly Gln His Ala Lys Val 
        35                  40                  45              


Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser 
    50                  55                  60                  


Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly 
65                  70                  75                  80  


Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu 
                85                  90                  95      


Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser 
            100                 105                 110         


Lys Gln Glu Gly Cys Arg Leu Cys Ala Gln Leu Arg Lys Cys Arg Pro 
        115                 120                 125             


Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys 
    130                 135                 140                 


Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp 
145                 150                 155                 160 


Ile Cys Arg Pro His Gln Ile Cys His Val Val Ala Ile Pro Gly Asn 
                165                 170                 175     


Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met 
            180                 185                 190         


Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln 
        195                 200                 205             


His Thr Gln Pro Thr Pro Ala Pro Ser Thr Ala Pro Gly Thr Ser Phe 
    210                 215                 220                 


Leu Leu Pro Val Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp 
225                 230                 235                 240 


Ile Val Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly Leu 
                245                 250                 255     


Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys Lys 
            260                 265                 270         


Lys Pro Leu Cys Leu Gln Arg Glu Thr Lys Val Pro His Leu Pro Ala 
        275                 280                 285             


Asp Lys Ala Arg Gly Ala Gln Gly Pro Glu Gln Gln His Leu Leu Thr 
    290                 295                 300                 


Thr Val Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser Ala 
305                 310                 315                 320 


Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly Ala 
                325                 330                 335     


Glu Lys Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
            340                 345                 350         


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
        355                 360                 365             


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
    370                 375                 380                 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ala Ser Pro Ser Gly Ser Pro 
385                 390                 395                 400 


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Ser Ala Phe Arg Ser 
                405                 410                 415     


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
            420                 425                 430         


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
        435                 440                 445 


<210>  139
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  139

Ala Cys Gly Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg 
1               5                   10                  15      


Leu Glu Glu Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln 
            20                  25                  30  


<210>  140
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 188

<400>  140

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  141
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 8

<400>  141

His Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ala Ser Arg His 
            20                  25                  30          


Cys Phe Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Arg Leu Asp Ser Gly Asp Ser Asn Leu Ala Tyr Ala Val Phe Val 
    50                  55                  60                  


Glu Gly Arg Phe Ala Ile Ser Gln Asp Asn Ala Leu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Ala Pro Cys His Arg Ala Pro Thr Phe Arg Pro Val 
            100                 105                 110         


Asp Phe Arg Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  142
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 12

<400>  142

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Asp Asp Gly Ser Val Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Glu Asp Gly Glu Leu Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  143
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 18

<400>  143

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  144
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 36

<400>  144

His Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Asp Asp Ser Asp Asn Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ile Arg Ile Gly Thr Asp Gln Tyr Lys Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  145
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 74

<400>  145

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser Ser 
            20                  25                  30          


Asp Met Thr Trp Val Arg Gln Thr Ser Gly Ser Val Phe Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asn Pro Asp Gly Gln Asn Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Ser Ser Gly Gly Ser Leu Ser Tyr Trp Gly Lys 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  146
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 79

<400>  146

His Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Tyr Thr Tyr Ser Ser Thr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Arg Ile Asp Thr Gly Gly Gly Asn Thr Tyr Tyr Leu Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Pro Ala Pro Cys His Gln Phe Leu Gly Leu Arg Gly Val 
            100                 105                 110         


Asp Phe Arg Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  147
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 82

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Leu Asp Ser 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Thr Phe Tyr Cys Gly Thr Thr Gln Thr Ser Arg Thr Pro Glu Val 
            100                 105                 110         


Val Asp Phe Ala Thr His Val Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  148
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 90

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Thr 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Glu Cys Glu Leu Val 
        35                  40                  45              


Thr Val Ile Ser Thr Asp Gly Asp Ile Tyr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Asp Ser Tyr Arg Leu Tyr Ser Ala Cys Gly Leu Ser Thr Ala 
            100                 105                 110         


Asp Phe Asp Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  149
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 118

<400>  149

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Tyr Arg Ser Asn 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Met Tyr Thr Gly Thr Asp Trp Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Lys Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Val Met Asn Asn Leu Lys Pro Asp Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Gly Phe Ile Cys Gly Tyr Asp Ser Asp Asp Asp Pro 
            100                 105                 110         


Tyr Asp Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  150
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 1248

<400>  150

His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Val Gly Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Gly Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Ser Asp Gly Ser Tyr Thr Asp Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Asn Tyr Tyr Ser Ser Tyr Cys Gln Val Asn Asp Phe Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  151
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 178

<400>  151

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Asp 
            20                  25                  30          


Asp Ala Thr Trp Ala Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Thr Leu Tyr Phe Asp Thr Glu Glu Lys Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Ile Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Gly Met Tyr Val Cys 
                85                  90                  95      


Thr Ala Thr Trp Ala Gly Gly Ser Leu Leu Arg Pro Ala Ser Phe Gly 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  152
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 210

<400>  152

His Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ala Ser Arg His 
            20                  25                  30          


Cys Phe Val Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Arg Leu Asp Ser Gly Asp Ser Asn Leu Ala Tyr Ala Val Phe Val 
    50                  55                  60                  


Glu Gly Arg Phe Ala Ile Ser Gln Asp Asn Ala Leu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Ala Pro Cys His Arg Ala Pro Thr Phe Arg Pro Val 
            100                 105                 110         


Asp Phe Arg Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  153
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 238

<400>  153

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Asp Ser Gly Ser Ala Tyr Leu Ser Tyr 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Tyr Gly Gly Asp Ser Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp His Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Gly Phe Ile Cys Gly Tyr Asp Ser Asp Asn Asp Pro Pro 
            100                 105                 110         


Asn Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  154
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 188

<400>  154

Arg Tyr Cys Leu Gly 
1               5   


<210>  155
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 188

<400>  155

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  156
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 188

<400>  156

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  157
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 8

<400>  157

Arg His Cys Phe Ala 
1               5   


<210>  158
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 8

<400>  158

Arg Leu Asp Ser Gly Asp Ser Asn Leu Ala Tyr Ala Val Phe Val Glu 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 8

<400>  159

Asp Pro Ala Pro Cys His Arg Ala Pro Thr Phe Arg Pro Val Asp Phe 
1               5                   10                  15      


Arg Ser 
        


<210>  160
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 12

<400>  160

Ser Tyr Gly Met Ser 
1               5   


<210>  161
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 12

<400>  161

Gly Ile Tyr Asp Asp Gly Ser Val Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 12

<400>  162

Gly Glu Asp Gly Glu Leu Asn Tyr 
1               5               


<210>  163
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 18

<400>  163

Arg Tyr Cys Met Gly 
1               5   


<210>  164
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 18

<400>  164

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  165
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 18

<400>  165

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  166
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 36

<400>  166

Ser Tyr Tyr Met Ser 
1               5   


<210>  167
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 36

<400>  167

Ala Ile Tyr Ser Asp Asp Ser Asp Asn Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  168
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 36

<400>  168

Ile Arg Ile Gly Thr Asp Gln Tyr Lys Phe 
1               5                   10  


<210>  169
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 74

<400>  169

Ser Ser Asp Met Thr 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 74

<400>  170

Asp Ile Asn Pro Asp Gly Gln Asn Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 74

<400>  171

Asp Pro Gly Ser Ser Gly Gly Ser Leu Ser Tyr 
1               5                   10      


<210>  172
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 79

<400>  172

Ser Thr Cys Met Gly 
1               5   


<210>  173
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 79

<400>  173

Arg Ile Asp Thr Gly Gly Gly Asn Thr Tyr Tyr Leu Ser Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 79

<400>  174

Asp Pro Ala Pro Cys His Gln Phe Leu Gly Leu Arg Gly Val Asp Phe 
1               5                   10                  15      


Arg Tyr 
        


<210>  175
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 82

<400>  175

Asp Ser Asp Met Gly 
1               5   


<210>  176
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 82

<400>  176

Ala Ile Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  177
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 82

<400>  177

Thr Phe Tyr Cys Gly Thr Thr Gln Thr Ser Arg Thr Pro Glu Val Val 
1               5                   10                  15      


Asp Phe Ala Thr His 
            20      


<210>  178
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 90

<400>  178

Asp Thr Asp Met Gly 
1               5   


<210>  179
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 90

<400>  179

Val Ile Ser Thr Asp Gly Asp Ile Tyr Tyr Thr Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  180
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 90

<400>  180

Arg Asp Ser Tyr Arg Leu Tyr Ser Ala Cys Gly Leu Ser Thr Ala Asp 
1               5                   10                  15      


Phe Asp Asp 
            


<210>  181
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 118

<400>  181

Ser Asn Cys Met Gly 
1               5   


<210>  182
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 118

<400>  182

Ala Met Tyr Thr Gly Thr Asp Trp Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 118

<400>  183

Asp Phe Gly Phe Ile Cys Gly Tyr Asp Ser Asp Asp Asp Pro Tyr Asp 
1               5                   10                  15      


Ala 
    


<210>  184
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 1248

<400>  184

Asp Tyr Gly Met Met 
1               5   


<210>  185
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 1248

<400>  185

Gly Ile Tyr Ser Asp Gly Ser Tyr Thr Asp Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  186
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 1248

<400>  186

Arg Asn Tyr Tyr Ser Ser Tyr Cys Gln Val Asn Asp Phe Gly Tyr 
1               5                   10                  15  


<210>  187
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 178

<400>  187

Ala Asp Asp Ala Thr 
1               5   


<210>  188
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 178

<400>  188

Thr Leu Tyr Phe Asp Thr Glu Glu Lys Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  189
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 178

<400>  189

Thr Trp Ala Gly Gly Ser Leu Leu Arg Pro Ala Ser Phe Gly Val 
1               5                   10                  15  


<210>  190
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 210

<400>  190

Arg His Cys Phe Val 
1               5   


<210>  191
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 210

<400>  191

Arg Leu Asp Ser Gly Asp Ser Asn Leu Ala Tyr Ala Val Phe Val Glu 
1               5                   10                  15      


Gly 
    


<210>  192
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 210

<400>  192

Asp Pro Ala Pro Cys His Arg Ala Pro Thr Phe Arg Pro Val Asp Phe 
1               5                   10                  15      


Arg Ser 
        


<210>  193
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 238

<400>  193

Ser Tyr Cys Met Ala 
1               5   


<210>  194
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 238

<400>  194

Ala Ile Tyr Tyr Gly Gly Asp Ser Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  195
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Clone 238

<400>  195

Asp Val Gly Phe Ile Cys Gly Tyr Asp Ser Asp Asn Asp Pro Pro Asn 
1               5                   10                  15      


Asp 
    


<210>  196
<211>  644
<212>  PRT
<213>  artificial sequence

<220>
<223>  3XVHHC188(G4S)1-Fc(Durv)(mini)

<400>  196

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Ser Val Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly 
        35                  40                  45              


Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Arg Glu Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala 
65                  70                  75                  80  


Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp 
                85                  90                  95      


Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu Cys Gly 
        115                 120                 125             


Tyr Asp Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys 
                165                 170                 175     


Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Arg Glu Arg Glu Gly Val Ala Ala Thr Ser Leu Thr 
        195                 200                 205             


Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser 
225                 230                 235                 240 


Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly 
                245                 250                 255     


Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly 
            260                 265                 270         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
    290                 295                 300                 


Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu 
305                 310                 315                 320 


Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val Ala Ala 
                325                 330                 335     


Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe 
385                 390                 395                 400 


Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys 
                405                 410                 415     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
            420                 425                 430         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        435                 440                 445             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    450                 455                 460                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
465                 470                 475                 480 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                485                 490                 495     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            500                 505                 510         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
        515                 520                 525             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    530                 535                 540                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
545                 550                 555                 560 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                565                 570                 575     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            580                 585                 590         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        595                 600                 605             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    610                 615                 620                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
625                 630                 635                 640 


Ser Pro Gly Lys 
                


<210>  197
<211>  622
<212>  PRT
<213>  artificial sequence

<220>
<223>  3XVHHC188(G4S)1-Fc(Durv)(mini)

<400>  197

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
    130                 135                 140                 


Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr 
145                 150                 155                 160 


Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu 
                165                 170                 175     


Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp 
225                 230                 235                 240 


Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys Ala Ile 
        275                 280                 285             


Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala 
    290                 295                 300                 


Pro Gly Arg Glu Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg 
305                 310                 315                 320 


Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg 
            340                 345                 350         


Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu 
        355                 360                 365             


Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly Gln Gly 
    370                 375                 380                 


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Asp Lys Thr His Thr 
385                 390                 395                 400 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
                405                 410                 415     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            420                 425                 430         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        435                 440                 445             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    450                 455                 460                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
465                 470                 475                 480 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                485                 490                 495     


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            500                 505                 510         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        515                 520                 525             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    530                 535                 540                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
545                 550                 555                 560 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                565                 570                 575     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            580                 585                 590         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        595                 600                 605             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620         


<210>  198
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_1

<400>  198

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  199
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_2

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  200
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_3

<400>  200

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  201
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_4

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  202
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_5

<400>  202

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  203
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_6

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  204
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_7

<400>  204

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  205
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_8

<400>  205

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  206
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_9

<400>  206

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  207
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_10

<400>  207

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  208
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_11

<400>  208

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  209
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_12

<400>  209

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  210
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_13

<400>  210

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  211
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_14

<400>  211

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  212
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH 15

<400>  212

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Ala Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  213
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_1

<400>  213

Arg Tyr Cys Leu 
1               


<210>  214
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_1

<400>  214

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  215
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_1

<400>  215

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  216
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_2

<400>  216

Arg Tyr Cys Leu 
1               


<210>  217
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_2

<400>  217

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  218
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_2

<400>  218

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  219
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_3

<400>  219

Arg Tyr Cys Leu 
1               


<210>  220
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_3

<400>  220

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  221
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_3

<400>  221

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  222
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_4

<400>  222

Arg Tyr Cys Leu 
1               


<210>  223
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_4

<400>  223

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  224
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_4

<400>  224

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  225
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_5

<400>  225

Arg Tyr Cys Leu 
1               


<210>  226
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_5

<400>  226

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  227
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_5

<400>  227

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  228
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_6

<400>  228

Arg Tyr Cys Leu 
1               


<210>  229
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_6

<400>  229

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  230
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_6

<400>  230

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  231
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_7

<400>  231

Arg Tyr Cys Leu 
1               


<210>  232
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_7

<400>  232

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  233
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_7

<400>  233

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  234
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_8

<400>  234

Arg Tyr Cys Leu 
1               


<210>  235
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_8

<400>  235

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  236
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_8

<400>  236

Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  237
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_9

<400>  237

Arg Tyr Cys Leu 
1               


<210>  238
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_9

<400>  238

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  239
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_9

<400>  239

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  240
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_10

<400>  240

Arg Tyr Cys Leu 
1               


<210>  241
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_10

<400>  241

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  242
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_10

<400>  242

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  243
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_11

<400>  243

Arg Tyr Cys Leu 
1               


<210>  244
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_11

<400>  244

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  245
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_11

<400>  245

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  246
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_12

<400>  246

Arg Tyr Cys Leu 
1               


<210>  247
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_12

<400>  247

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  248
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_12

<400>  248

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  249
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_13

<400>  249

Arg Tyr Cys Leu 
1               


<210>  250
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_13

<400>  250

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  251
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_13

<400>  251

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  252
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_14

<400>  252

Arg Tyr Cys Leu 
1               


<210>  253
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_14

<400>  253

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  254
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH_14

<400>  254

Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  255
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH 15

<400>  255

Arg Tyr Ala Leu 
1               


<210>  256
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH 15

<400>  256

Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  257
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  C188-VHH 15

<400>  257

Asp Val Gly Phe Leu Ala Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr 
1               5                   10                  15      


Asp 
    


<210>  258
<211>  714
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain (signal peptide + C4-VH + DURVA[CH1 + Hinge + CH2 + 
       CH3] + scFvC4(C4-Vh-linker-C4-VL)

<400>  258

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val 
465                 470                 475                 480 


Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser 
                485                 490                 495     


Phe Thr Ser Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly 
            500                 505                 510         


Leu Glu Trp Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr 
        515                 520                 525             


Asn Glu Lys Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser 
    530                 535                 540                 


Asn Thr Ala Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala 
545                 550                 555                 560 


Val Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
                565                 570                 575     


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp 
    610                 615                 620                 


Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val 
625                 630                 635                 640 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
                645                 650                 655     


Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser 
            660                 665                 670         


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu 
        675                 680                 685             


Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Trp Thr 
    690                 695                 700                 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
705                 710                 


<210>  259
<211>  695
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain (C4-VH + DURVA[CH1 + Hinge + CH2 + CH3] + 
       scFvC4(C4-Vh-linker-C4-VL)

<400>  259

Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    450                 455                 460                 


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser 
465                 470                 475                 480 


Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                485                 490                 495     


Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys 
            500                 505                 510         


Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala 
        515                 520                 525             


Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    530                 535                 540                 


Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
545                 550                 555                 560 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
            580                 585                 590         


Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser 
        595                 600                 605             


Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr 
    610                 615                 620                 


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
625                 630                 635                 640 


Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                645                 650                 655     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            660                 665                 670         


Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Trp Thr Phe Gly Gln 
        675                 680                 685             


Gly Thr Lys Val Glu Ile Lys 
    690                 695 


<210>  260
<211>  236
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain (signal peptide + C4-VL + durvaCL)

<400>  260

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser His Lys Phe 
            20                  25                  30          


Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  261
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain (C4-VL + durvaCL)

<400>  261

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  262
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  262

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  263
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  263

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  264
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  264

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  265
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  265

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  266
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  266

Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala 
1               5                   10      


<210>  267
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  267

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  268
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  268

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  269
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  269

Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala 
1               5                   10      


<210>  270
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  270

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  271
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  271

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  272
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  272

Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala 
1               5                   10      


<210>  273
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  273

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  274
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  274

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  275
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  275

Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala 
1               5                   10      


<210>  276
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  276

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  277
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain sequences

<400>  277

Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
1               5                   


<210>  278
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  278

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  279
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  279

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  280
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  280

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  281
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  281

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  282
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  282

Ser Tyr Asp Ile Asn 
1               5   


<210>  283
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  283

Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly Arg Val Thr 
            20  


<210>  284
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  284

Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  285
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  285

Ser Tyr Asp Ile Asn 
1               5   


<210>  286
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  286

Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly Arg Val Thr 
            20  


<210>  287
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  287

Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  288
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  288

Ser Tyr Asp Ile Asn 
1               5   


<210>  289
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  289

Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly Arg Val Thr 
            20  


<210>  290
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  290

Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  291
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  291

Ser Tyr Asp Ile Asn 
1               5   


<210>  292
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  292

Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala Glu Lys Phe Gln 
1               5                   10                  15      


Gly Arg Val Thr 
            20  


<210>  293
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain sequences

<400>  293

Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  294
<211>  135
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 VL

<400>  294

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Ile Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Thr Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Val Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Val Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Glu Thr Asn Lys Ala Thr Leu 
    130                 135 


<210>  295
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VL

<400>  295

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Gly Ser Glu Ile Lys 
            100                 105                 


<210>  296
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VL

<400>  296

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  297
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VL

<400>  297

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  298
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VL

<400>  298

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Asn Ile Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Tyr Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  299
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VL

<400>  299

Tyr Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asn Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln His Phe Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  300
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VL

<400>  300

Asp Ile Val Met Ala Gln Ser Gln Lys Phe Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Phe Asp Ser His Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  301
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VL

<400>  301

Asp Ile Val Met Thr Gln Ala Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Leu 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser His Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  302
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-1 VL

<400>  302

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ala Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Phe Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  303
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31-2 VL

<400>  303

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Val Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  304
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VL

<400>  304

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  305
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C1 Vh

<400>  305

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Ser Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Leu Trp Leu Arg Thr Ala Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ile Thr Val Ser Ser 
        115                 


<210>  306
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4 VH

<400>  306

Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  307
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C8 VH

<400>  307

Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Ser Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Leu Trp Leu Arg Thr Ala Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ile Thr Val Ser Ser 
        115                 


<210>  308
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  C9 VH

<400>  308

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Asp Gly Thr Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  309
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  C15 VH

<400>  309

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Thr Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Val Asp Pro Gly Thr Gly Asp Thr Ala Ser Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Met Leu Thr Ala Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Tyr Tyr Gly Ser Arg Glu Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  310
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  C16 VH

<400>  310

Glu Val Lys Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ser Asp Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Ser Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Tyr Asp Asn Glu Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  311
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  C19 VH

<400>  311

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile His 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asn Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Glu Val Arg Arg Gly Phe Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  312
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  C25 VH

<400>  312

Glu Val Leu Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Gln Asp Leu 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Thr Asp Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Gly Leu Leu Gln Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Ala Val Thr Val Ser Ser 
        115             


<210>  313
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH

<400>  313

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Asn Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Glu Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Trp Phe His Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  314
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C31 VH

<400>  314

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Ser Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Asn Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Glu Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Trp Phe His Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  315
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C40 VH

<400>  315

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Glu Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ile Ala Gly Thr Arg Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  316
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  Durv heavy chain constant region sequences with CH1 deletion

<400>  316

Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  317
<211>  714
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var7

<400>  317

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala 
65                  70                  75                  80  


Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
465                 470                 475                 480 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser 
                485                 490                 495     


Phe Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly 
            500                 505                 510         


Leu Glu Trp Met Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr 
        515                 520                 525             


Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser 
    530                 535                 540                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
545                 550                 555                 560 


Thr Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
                565                 570                 575     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly Asp 
    610                 615                 620                 


Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val 
625                 630                 635                 640 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
                645                 650                 655     


Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
            660                 665                 670         


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        675                 680                 685             


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
    690                 695                 700                 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
705                 710                 


<210>  318
<211>  468
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var7

<400>  318

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala 
65                  70                  75                  80  


Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  319
<211>  714
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var16

<400>  319

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala 
65                  70                  75                  80  


Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys 
465                 470                 475                 480 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser 
                485                 490                 495     


Phe Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly 
            500                 505                 510         


Leu Glu Trp Met Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr 
        515                 520                 525             


Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser 
    530                 535                 540                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
545                 550                 555                 560 


Thr Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val 
                565                 570                 575     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        595                 600                 605             


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    610                 615                 620                 


Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val 
625                 630                 635                 640 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
                645                 650                 655     


Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
            660                 665                 670         


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
        675                 680                 685             


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr 
    690                 695                 700                 


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
705                 710                 


<210>  320
<211>  468
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var16

<400>  320

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala 
65                  70                  75                  80  


Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  321
<211>  236
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var7

<400>  321

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  322
<211>  482
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var7

<400>  322

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu 
225                 230                 235                 240 


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                245                 250                 255     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Tyr 
        275                 280                 285             


Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val 
    290                 295                 300                 


Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
305                 310                 315                 320 


Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Thr 
                325                 330                 335     


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    370                 375                 380                 


Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
385                 390                 395                 400 


Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                405                 410                 415     


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly 
            420                 425                 430         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        435                 440                 445             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln 
    450                 455                 460                 


Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
465                 470                 475                 480 


Ile Lys 
        


<210>  323
<211>  236
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var16

<400>  323

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  324
<211>  482
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4_var16

<400>  324

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu 
225                 230                 235                 240 


Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
                245                 250                 255     


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Tyr 
        275                 280                 285             


Pro Arg Glu Gly Asp Thr Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val 
    290                 295                 300                 


Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser 
305                 310                 315                 320 


Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Leu Thr 
                325                 330                 335     


Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    370                 375                 380                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
385                 390                 395                 400 


Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                405                 410                 415     


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly 
            420                 425                 430         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        435                 440                 445             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln 
    450                 455                 460                 


Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
465                 470                 475                 480 


Ile Lys 
        


<210>  325
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4'_VL

<400>  325

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  326
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  C4'_HL

<400>  326

Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  327
<211>  707
<212>  PRT
<213>  artificial sequence

<220>
<223>  3xVHHC188(G4S)5-Fc(DANA)-Flag

<400>  327

Met Asn Phe Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Pro Arg Gly Thr Asp Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Thr Leu 
        35                  40                  45              


Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp 
    50                  55                  60                  


Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val Ala Ala Thr Ser 
65                  70                  75                  80  


Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met 
            100                 105                 110         


Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp 
        115                 120                 125             


Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr Asp 
    130                 135                 140                 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Arg Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly 
            180                 185                 190         


Ser Val Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly 
        195                 200                 205             


Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly 
    210                 215                 220                 


Arg Glu Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala 
225                 230                 235                 240 


Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp 
                245                 250                 255     


Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp 
            260                 265                 270         


Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu Cys Gly 
        275                 280                 285             


Tyr Asp Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln 
    290                 295                 300                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu 
                325                 330                 335     


Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
            340                 345                 350         


Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
        355                 360                 365             


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val 
    370                 375                 380                 


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
385                 390                 395                 400 


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
                405                 410                 415     


Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr 
            420                 425                 430         


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
        435                 440                 445             


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    450                 455                 460                 


Ala Ser Ala Gly Ser Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
465                 470                 475                 480 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                485                 490                 495     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            500                 505                 510         


Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        515                 520                 525             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    530                 535                 540                 


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
545                 550                 555                 560 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                565                 570                 575     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            580                 585                 590         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        595                 600                 605             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    610                 615                 620                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
625                 630                 635                 640 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                645                 650                 655     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            660                 665                 670         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        675                 680                 685             


Leu Ser Leu Ser Pro Gly Lys Glu Phe Asp Tyr Lys Asp Asp Asp Asp 
    690                 695                 700                 


Lys Leu Glu 
705         


<210>  328
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge with 3 cysteines

<400>  328

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  329
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge with 2 cysteines

<400>  329

Glu Pro Lys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  330
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3XVHHC188(G4S)1-Fc(Durv)

<400>  330

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Ser Asp Asn Asp 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val 
    130                 135                 140                 


Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys Ala Ile Ser Gly Ser Thr 
145                 150                 155                 160 


Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Arg Glu 
                165                 170                 175     


Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Pro Asp Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp 
225                 230                 235                 240 


Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Ser Val Gln Thr Gly Gly Ser Leu Thr Leu Ser Cys Ala Ile 
        275                 280                 285             


Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala 
    290                 295                 300                 


Pro Gly Arg Glu Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg 
305                 310                 315                 320 


Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg 
            340                 345                 350         


Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu 
        355                 360                 365             


Cys Gly Tyr Asp Ser Asp Asn Asp Pro Phe Tyr Asp Trp Gly Gln Gly 
    370                 375                 380                 


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Asp Lys Thr His Thr 
385                 390                 395                 400 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
                405                 410                 415     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            420                 425                 430         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        435                 440                 445             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    450                 455                 460                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
465                 470                 475                 480 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                485                 490                 495     


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            500                 505                 510         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        515                 520                 525             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    530                 535                 540                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
545                 550                 555                 560 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                565                 570                 575     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            580                 585                 590         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        595                 600                 605             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620         


<210>  331
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3XVHHC188-var14(G4S)1-Fc(Durv)

<400>  331

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu 
            100                 105                 110         


Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr 
145                 150                 155                 160 


Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp 
225                 230                 235                 240 


Thr Asp Asn Glu Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile 
        275                 280                 285             


Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala 
    290                 295                 300                 


Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg 
305                 310                 315                 320 


Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu 
        355                 360                 365             


Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr Asp Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser Asp Lys Thr His Thr 
385                 390                 395                 400 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
                405                 410                 415     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            420                 425                 430         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        435                 440                 445             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    450                 455                 460                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
465                 470                 475                 480 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                485                 490                 495     


Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser 
            500                 505                 510         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        515                 520                 525             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    530                 535                 540                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
545                 550                 555                 560 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                565                 570                 575     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            580                 585                 590         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        595                 600                 605             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620         


<210>  332
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4-IgG1(Durv)-HC:scFvC4(G4S)4 - Light chain (C4-VL + durva-CL)

<400>  332

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  333
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4-IgG1(Durv)-HC:scFvC4(G4S)4 - Heavy chain (C4-VH + DURVA[CH1 + 
       Hinge + CH2 + CH3] + scFvC4(C4-Vh-linker-C4-VL)

<400>  333

Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gln Val Gln Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    450                 455                 460                 


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser 
465                 470                 475                 480 


Tyr Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                485                 490                 495     


Val Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Asn Glu Lys 
            500                 505                 510         


Phe Lys Gly Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Asn Thr Ala 
        515                 520                 525             


Tyr Met Asn Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    530                 535                 540                 


Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
545                 550                 555                 560 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
            580                 585                 590         


Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser 
        595                 600                 605             


Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr 
    610                 615                 620                 


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
625                 630                 635                 640 


Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
                645                 650                 655     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            660                 665                 670         


Arg Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Trp Thr Phe Gly Gln 
        675                 680                 685             


Gly Thr Lys Val Glu Ile Lys 
    690                 695 


<210>  334
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4var7-IgG1(Durv)-HC:scFvC4var7(G4S)4 - Light chain ~= C4var7-VL 
       + durva-CL)

<400>  334

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  335
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4var7-IgG1(Durv)-HC:scFvC4var7(G4S)4 - Heavy chain ~= C4var7-VH 
       + DURVA[CH1 + Hinge + CH2 + CH3] + 
       scFvC4var7[C4-Vh_2-linker-C4-VL_3]

<400>  335

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly 
    450                 455                 460                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser 
465                 470                 475                 480 


Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                485                 490                 495     


Met Gly Trp Ile Tyr Pro Arg Asp Gly Asp Thr Lys Tyr Ala Glu Lys 
            500                 505                 510         


Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala 
        515                 520                 525             


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe 
    530                 535                 540                 


Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln 
545                 550                 555                 560 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
            580                 585                 590         


Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr 
        595                 600                 605             


Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala Val Ala Trp Tyr 
    610                 615                 620                 


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
625                 630                 635                 640 


Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                645                 650                 655     


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala 
            660                 665                 670         


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro Thr Phe Gly Gly 
        675                 680                 685             


Gly Thr Lys Leu Glu Ile Lys 
    690                 695 


<210>  336
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4var16-IgG1(Durv)-LC:scFvC4var16(G4S)4 - Light chain ~= 
       C4var16-VL + durva-CL + scFvC4var16[C4-Vh_4-linker-C4-VL_4]

<400>  336

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Val Gln Ser Gly Pro Glu 
    210                 215                 220                 


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
225                 230                 235                 240 


Tyr Ser Phe Thr Ser Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
                245                 250                 255     


Gln Gly Leu Glu Trp Met Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr 
            260                 265                 270         


Lys Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Val Asp Thr 
        275                 280                 285             


Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
    290                 295                 300                 


Thr Ala Thr Tyr Phe Cys Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe 
305                 310                 315                 320 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        355                 360                 365             


Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Asp Thr 
    370                 375                 380                 


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
385                 390                 395                 400 


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser 
                405                 410                 415     


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
            420                 425                 430         


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Val Pro 
        435                 440                 445             


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    450                 455                 460 


<210>  337
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4var16-IgG1(Durv)-LC:scFvC4var16(G4S)4 - Heavy chain ~= 
       C4var16-VH + DURVA[CH1 + Hinge + CH2 + CH3]

<400>  337

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Glu Gly Asp Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Thr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  338
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3XVHHC188-var14(G4S)1-Fc(Durv) - (signal peptide + C188variant14 
       + G4S + C188variant14 + G4S + C188variant14 + hinge + 
       Fc(Durvalumab)

<400>  338

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly 
        35                  40                  45              


Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Arg Glu Gly Val Ala Ala Thr Ser Leu Thr Gly Arg Gly Ala 
65                  70                  75                  80  


Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Leu Asp 
                85                  90                  95      


Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly Phe Leu Cys Gly 
        115                 120                 125             


Tyr Asp Thr Asp Asn Glu Pro Phe Tyr Asp Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Thr Ser Leu Thr 
        195                 200                 205             


Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
225                 230                 235                 240 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Glu Asp Val Gly 
                245                 250                 255     


Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe Tyr Asp Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Glu Val 
        275                 280                 285             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    290                 295                 300                 


Arg Leu Ser Cys Ala Ile Ser Gly Ser Thr Ser Glu Arg Tyr Cys Leu 
305                 310                 315                 320 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala 
                325                 330                 335     


Thr Ser Leu Thr Gly Arg Gly Ala Gln Phe Tyr Ala Asp Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Leu Asp Asp Ala Lys Asn Thr Leu Tyr Leu 
        355                 360                 365             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    370                 375                 380                 


Glu Asp Val Gly Phe Leu Cys Gly Tyr Asp Thr Asp Asn Glu Pro Phe 
385                 390                 395                 400 


Tyr Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys 
                405                 410                 415     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
            420                 425                 430         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        435                 440                 445             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    450                 455                 460                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
465                 470                 475                 480 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                485                 490                 495     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            500                 505                 510         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
        515                 520                 525             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    530                 535                 540                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
545                 550                 555                 560 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                565                 570                 575     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            580                 585                 590         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        595                 600                 605             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    610                 615                 620                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
625                 630                 635                 640 


Ser Pro Gly Lys 
                


