               SEQUENCE LISTING

<110> GIVAUDAN SA

<120> CHONDROITIN-PRODUCING RECOMBINANT CELL

<130> PR92298/MGG

<150> EP21166740.7
<151> 2021-04-01

<160> 128

<170> BiSSAP 1.3.6

<210> 1
<211> 2919
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having a
      chondroitin synthase activity (HCOS-1)

<400> 1
atgaacaccc tttcccaggc aattaaggct tataatagta atgattatca actagccctc      60

aagctgttcg aaaagtcggc agaaatctac ggcagaaaga tagttgagtt ccaaattacg     120

aagtgcaagg agaaactttc tgcgcaccca tccgttaaca gtgcgcatct ctcggttaac     180

aaagaagaga aggtgaatgt ttgcgacagt ccattagaca tagccactca attattgtta     240

tcgaatgtga aaaaactcgt ccttagtgat agcgagaaaa atacactaaa gaataaatgg     300

aagttgttga ctgaaaagaa gtctgagaac gcagaggtcc gggccgtagc tttagttccc     360

aaggactttc cgaaagattt agtgcttgcg ccgttaccag accatgtgaa cgattttacg     420

tggtataaga agcggaagaa acgcctagga atcaaaccag aacaccaaca cgttggcctc     480

tccattattg tgacaacgtt caaccgtcct gccatcctca gcatcaccct ggcttgcctc     540

gtcaatcaaa agacccatta tccttttgag gtgatcgtga ccgacgatgg ttctcaagag     600

gatttatcgc ctataatccg tcaatatgag aacaagctag acatccgtta tgttcggcaa     660

aaggactatg ggtatcagct gtgcgccgtt agaaaccttg gtctaaggac agcgaagtat     720

gactttgtct ctatcttgga ttgcgacatg gccccgcagc agctatgggt tcactcttac     780

cttacagaac tattagagga cgatgatttg accataatag gccccaggaa gtacattgac     840

acgcaacaca tagatcccaa ggatttcctt aataacgcct ctctgttaga gtcgttgcca     900

gaggttaaga ccaataattc cgtcgcggct aagggcgagg ggaccgtatc tttagactgg     960

cgtttggaac aatttgagaa gaccgagaac ttgaggctat ccgatagccc tttccgattc    1020

ttcgcagctg ggaatgtggc tttcgccaag aagtggctta acaagtcagg attcttcgac    1080

gaggaattca atcactgggg aggtgaagat gtagagttcg gttatcgtct gtttcggtac    1140

ggttcgttct tcaaaactat agacggcatc atggcctatc atcaggaacc gccaggtaaa    1200

gaaaacgaaa ctgacagaga agcgggcaag aacattaccc tcgatataat gagggagaag    1260

gtgccttaca tctaccgtaa actcctgcct atagaagaca gtcatatcaa ccgagtacca    1320

ttggtatcaa tttacatccc ggcctacaac tgtgctaact atattcaaag atgtgttgat    1380

tcagctttga atcaaacggt agttgatctc gaagtgtgca tttgcaacga cggtagtact    1440

gacaacacgc tggaagttat taacaagctg tatggtaata atccgcgtgt gcgtataatg    1500

tctaaaccca atggcggcat tgcgagtgca tccaacgcag cggtcagctt cgcaaagggt    1560

tattacatag gacagttgga cagcgacgat tacttagaac ccgacgcagt ggagttatgt    1620

ctcaaggaat ttcttaagga taagaccctt gcgtgcgttt acaccactaa tcgtaacgtc    1680

aacccagatg gctctttaat agccaatggc tataactggc cagagttcag tcgtgagaag    1740

ttgactacgg ccatgattgc tcatcacttc cggatgttta ccattcgtgc ttggcatctg    1800

acggatgggt tcaatgagaa gattgagaac gctgttgact acgacatgtt tctcaagctc    1860

agtgaagttg gtaaatttaa gcatctgaac aaaatatgtt ataatcgggt gttacacggc    1920

gataacacct caatcaagaa gcttggcata caaaagaaga atcatttcgt agttgtcaat    1980

cagtctctaa accgccaagg tataacttat tataactacg atgaatttga tgatctcgat    2040

gagagtcgga aatacatttt caacaagact gcagagtatc aagaagagat agatattctt    2100

aaagatatta agatcattca gaacaaagac gccaaaatag ctgtctccat tttctatccg    2160

aacactctaa acgggttggt gaagaagcta aataatatta tagagtataa taagaatatc    2220

ttcgttattg tacttcatgt cgataagaat cacttaaccc cagacatcaa gaaggagata    2280

ttagccttct accataagca tcaggtgaac atcttattga acaatgacat ctcctactat    2340

acatcaaatc gtctgattaa gacagaagcc catttgagta acattaacaa gctaagtcaa    2400

ttaaatctta actgcgaata cattatattc gacaatcacg attccttatt tgtgaagaac    2460

gattcctatg catacatgaa gaagtatgat gttggaatga acttctctgc attgactcat    2520

gattggattg aaaagataaa cgctcacccg ccatttaaga agctgatcaa aacttacttc    2580

aatgacaatg atcttaagtc gatgaatgta aagggtgcct cccagggaat gtttatgaca    2640

tacgcattag cccacgagtt attgacgatc atcaaggagg tgataacctc ttgtcaatcc    2700

attgactccg tccccgaata caacacagaa gatatttggt ttcagtttgc acttttaatt    2760

ctggaaaaga agaccggcca cgtattcaac aagacaagca ctctcacgta tatgccatgg    2820

gaacgtaaac tgcagtggac gaatgaacaa atagagtccg caaagagggg cgaaaacatt    2880

ccggtaaaca agttcatcat taacagcatt accctttaa                           2919


<210> 2
<211> 2919
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having a
      chondroitin synthase activity (HCOS1-2)

<400> 2
atgaacaccc tttcccaggc aattaaggct tataatagta atgattatca actagccctc      60

aagctgttcg aaaagtcggc agaaatctac ggcagaaaga tagttgagtt ccaaattacg     120

aagtgcaagg agaaactttc tgcgcaccca tccgttaaca gtgcgcatct ctcggttaac     180

aaagaagaga aggtgaatgt ttgcgacagt ccattagaca tagccactca attattgtta     240

tcgaatgtga aaaaactcgt ccttagtgat agcgagaaaa atacactaaa gaataaatgg     300

aagttgttga ctgaaaagaa gtctgagaac gcagaggtcc gggccgtagc tttagttccc     360

aaggactttc cgaaagattt agtgcttgcg ccgttaccag accatgtgaa cgattttacg     420

tggtataaga agcggaagaa acgcctagga atcaaaccag tgaacaagaa catcgggttg     480

tcaatcataa tcccaacttt caatcgtagt aggatattag acatcaccct ggcttgcctc     540

gtcaatcaaa agacccatta tccttttgag gtgatcgtga ccgacgatgg ttctcaagag     600

gatttatcgc ctataatccg tcaatatgag aacaagctag acatccgtta tgttcggcaa     660

aaggactatg ggtatcagct gtgcgccgtt agaaaccttg gtctaaggac agcgaagtat     720

gactttgtct ctatcttgga ttgcgacatg gccccgcagc agctatgggt tcactcttac     780

cttacagaac tattagagga cgatgatttg accataatag gccccaggaa gtacattgac     840

acgcaacaca tagatcccaa ggatttcctt aataacgcct ctctgttaga gtcgttgcca     900

gaggttaaga ccaataattc cgtcgcggct aagggcgagg ggaccgtatc tttagactgg     960

cgtttggaac aatttgagaa gaccgagaac ttgaggctat ccgatagccc tttccgattc    1020

ttctcatgcg gaaatgtggc cttctccaaa gagtggctga acaaagttgg ctggttcgac    1080

gaggaattca atcactgggg aggtgaagat gtagagttcg gttatcgtct gtttcggtac    1140

ggttcgttct tcaaaactat agacggcatc atggcctatc atcaggaacc gccaggtaaa    1200

gaaaacgaaa ctgacagaga agcgggcaag aacattaccc tcgatataat gagggagaag    1260

gtgccttaca tctaccgtaa actcctgcct atagaagaca gtcatatcaa ccgagtacca    1320

ttggtatcaa tttacatccc ggcctacaac tgtgctaact atattcaaag atgtgttgat    1380

tcagctttga atcaaacggt agttgatctc gaagtgtgca tttgcaacga cggtagtact    1440

gacaacacgc tggaagttat taacaagctg tatggtaata atccgcgtgt gcgtataatg    1500

tctaaaccca atggcggcat tgcgagtgca tccaacgcag cggtcagctt cgcaaagggt    1560

tattacatag gacagttgga cagcgacgat tacttagaac ccgacgcagt ggagttatgt    1620

ctcaaggaat ttcttaagga taagaccctt gcgtgcgttt acaccactaa tcgtaacgtc    1680

aacccagatg gctctttaat agccaatggc tataactggc cagagttcag tcgtgagaag    1740

ttgactacgg ccatgattgc tcatcacttc cggatgttta ccattcgtgc ttggcatctg    1800

acggatgggt tcaatgagaa gattgagaac gctgttgact acgacatgtt tctcaagctc    1860

agtgaagttg gtaaatttaa gcatctgaac aaaatatgtt ataatcgggt gttacacggc    1920

gataacacct caatcaagaa gcttggcata caaaagaaga atcatttcgt agttgtcaat    1980

cagtctctaa accgccaagg tataacttat tataactacg atgaatttga tgatctcgat    2040

gagagtcgga aatacatttt caacaagact gcagagtatc aagaagagat agatattctt    2100

aaagatatta agatcattca gaacaaagac gccaaaatag ctgtctccat tttctatccg    2160

aacactctaa acgggttggt gaagaagcta aataatatta tagagtataa taagaatatc    2220

ttcgttattg tacttcatgt cgataagaat cacttaaccc cagacatcaa gaaggagata    2280

ttagccttct accataagca tcaggtgaac atcttattga acaatgacat ctcctactat    2340

acatcaaatc gtctgattaa gacagaagcc catttgagta acattaacaa gctaagtcaa    2400

ttaaatctta actgcgaata cattatattc gacaatcacg attccttatt tgtgaagaac    2460

gattcctatg catacatgaa gaagtatgat gttggaatga acttctctgc attgactcat    2520

gattggattg aaaagataaa cgctcacccg ccatttaaga agctgatcaa aacttacttc    2580

aatgacaatg atcttaagtc gatgaatgta aagggtgcct cccagggaat gtttatgaca    2640

tacgcattag cccacgagtt attgacgatc atcaaggagg tgataacctc ttgtcaatcc    2700

attgactccg tccccgaata caacacagaa gatatttggt ttcagtttgc acttttaatt    2760

ctggaaaaga agaccggcca cgtattcaac aagacaagca ctctcacgta tatgccatgg    2820

gaacgtaaac tgcagtggac gaatgaacaa atagagtccg caaagagggg cgaaaacatt    2880

ccggtaaaca agttcatcat taacagcatt accctttaa                           2919


<210> 3
<211> 2919
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having a
      chondroitin synthase activity (HCOS1-3)

<400> 3
atgaacaccc tttcccaggc aattaaggct tataatagta atgattatca actagccctc      60

aagctgttcg aaaagtcggc agaaatctac ggcagaaaga tagttgagtt ccaaattacg     120

aagtgcaagg agaaactttc tgcgcaccca tccgttaaca gtgcgcatct ctcggttaac     180

aaagaagaga aggtgaatgt ttgcgacagt ccattagaca tagccactca attattgtta     240

tcgaatgtga aaaaactcgt ccttagtgat agcgagaaaa atacactaaa gaataaatgg     300

aagttgttga ctgaaaagaa gtctgagaac gcagaggtcc gggccgtagc tttagtccca     360

aaggattttc ccaaagactt agttttagcg ccactaccag accatgtgaa cgattttacc     420

tggtacaaga atagaaagaa gagcctgggc ataaagcctg tgaacaagaa catcgggttg     480

tcaatcataa tcccaacttt caatcgtagt aggatattag acattaccct ggcgtgtcta     540

gttaatcaga aaactaacta tccgtttgag gtggttgttg cagatgatgg gtcgaaggaa     600

aatctattga ctatagttca gaaatacgag cagaaactag acattaagta tgtgagacag     660

aaggactatg ggtatcagct gtgcgccgtt agaaaccttg gtctaaggac agcgaagtat     720

gactttgtct ctatcttgga ttgcgacatg gccccgcagc agctatgggt tcactcttac     780

cttacagagt tactggaaga caacgacatc gtcttgatcg ggccaaggaa atacgttgat     840

acccacaaca tcacggctga gcagtttctg aacgacccat atttaattga gagtttaccg     900

gaaaccgcca caaacaataa tccatcgatt accagtaagg gtaacatctc attagattgg     960

agattagaac attttaagaa gacagacaac ctaagactat gcgactcccc gttcaggtat    1020

ttctcatgcg gaaatgtggc cttctccaaa gagtggctga acaaagttgg ctggttcgac    1080

gaagaattta atcactgggg cggcgaagac gtcgaattcg gctacaggtt atttgcaaaa    1140

gggtgcttct ttagggttat cgacggtggt atggcctacc atcaagagcc accaggaaag    1200

gagaacgaaa cggatcgtga ggccggtaag tctatcactc ttaaaatagt aaaggagaaa    1260

gtgccctaca tctacaggaa gttgttgccg attgaggact cccacataaa ccgagtacca    1320

ttggtatcaa tttacatccc ggcctacaac tgtgctaact atattcaaag atgtgttgat    1380

tcagctttga atcaaacggt agttgatctc gaagtgtgca tttgcaacga cggtagtact    1440

gacaacacgc tggaagttat taacaagctg tatggtaata atccgcgtgt gcgtataatg    1500

tctaaaccca atggcggcat tgcgagtgca tccaacgcag cggtcagctt cgcaaagggt    1560

tattacatag gacagttgga cagcgacgat tacttagaac ccgacgcagt ggagttatgt    1620

ctcaaggaat ttcttaagga taagaccctt gcgtgcgttt acaccactaa tcgtaacgtc    1680

aacccagatg gctctttaat agccaatggc tataactggc cagagttcag tcgtgagaag    1740

ttgactacgg ccatgattgc tcatcacttc cggatgttta ccattcgtgc ttggcatctg    1800

acggatgggt tcaatgagaa gattgagaac gctgttgact acgacatgtt tctcaagctc    1860

agtgaagttg gtaaatttaa gcatctgaac aaaatatgtt ataatcgggt gttacacggc    1920

gataacacct caatcaagaa gcttggcata caaaagaaga atcatttcgt agttgtcaat    1980

cagtctctaa accgccaagg tataacttat tataactacg atgaatttga tgatctcgat    2040

gagagtcgga aatacatttt caacaagact gcagagtatc aagaagagat agatattctt    2100

aaagatatta agatcattca gaacaaagac gccaaaatag ctgtctccat tttctatccg    2160

aacactctaa acgggttggt gaagaagcta aataatatta tagagtataa taagaatatc    2220

ttcgttattg tacttcatgt cgataagaat cacttaaccc cagacatcaa gaaggagata    2280

ttagccttct accataagca tcaggtgaac atcttattga acaatgacat ctcctactat    2340

acatcaaatc gtctgattaa gacagaagcc catttgagta acattaacaa gctaagtcaa    2400

ttaaatctta actgcgaata cattatattc gacaatcacg attccttatt tgtgaagaac    2460

gattcctatg catacatgaa gaagtatgat gttggaatga acttctctgc attgactcat    2520

gattggattg aaaagataaa cgctcacccg ccatttaaga agctgatcaa aacttacttc    2580

aatgacaatg atcttaagtc gatgaatgta aagggtgcct cccagggaat gtttatgaca    2640

tacgcattag cccacgagtt attgacgatc atcaaggagg tgataacctc ttgtcaatcc    2700

attgactccg tccccgaata caacacagaa gatatttggt ttcagtttgc acttttaatt    2760

ctggaaaaga agaccggcca cgtattcaac aagacaagca ctctcacgta tatgccatgg    2820

gaacgtaaac tgcagtggac gaatgaacaa atagagtccg caaagagggg cgaaaacatt    2880

ccggtaaaca agttcatcat taacagcatt accctttaa                           2919


<210> 4
<211> 3072
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS.Sc)

<400> 4
atgaacaccc tttcccaggc aattaaggct tataatagta atgattatca actagccctc      60

aagctgttcg aaaagtcggc agaaatctac ggcagaaaga tagttgagtt ccaaattacg     120

aagtgcaagg agaaactttc tgcgcaccca tccgttaaca gtgcgcatct ctcggttaac     180

aaagaagaga aggtgaatgt ttgcgacagt ccattagaca tagccactca attattgtta     240

tcgaatgtga aaaaactcgt ccttagtgat agcgagaaaa atacactaaa gaataaatgg     300

aagttgttga ctgaaaagaa gtctgagaac gcagaggtcc gggccgtagc tttagtccca     360

aaggattttc ccaaagactt agttttagcg ccactaccag accatgtgaa cgattttacc     420

tggtacaaga atagaaagaa gagcctgggc ataaagcctg tgaacaagaa catcgggttg     480

tcaatcataa tcccaacttt caatcgtagt aggatattag acattaccct ggcgtgtcta     540

gttaatcaga aaactaacta tccgtttgag gtggttgttg cagatgatgg gtcgaaggaa     600

aatctattga ctatagttca gaaatacgag cagaaactag acattaagta tgtgagacag     660

aaggactatg ggtatcagct gtgcgccgtt agaaaccttg gtctaaggac agcgaagtat     720

gactttgtct ctatcttgga ttgcgacatg gccccgcagc agctatgggt tcactcttac     780

cttacagagt tactggaaga caacgacatc gtcttgatcg ggccaaggaa atacgttgat     840

acccacaaca tcacggctga gcagtttctg aacgacccat atttaattga gagtttaccg     900

gaaaccgcca caaacaataa tccatcgatt accagtaagg gtaacatctc attagattgg     960

agattagaac attttaagaa gacagacaac ctaagactat gcgactcccc gttcaggtat    1020

ttctcatgcg gaaatgtggc cttctccaaa gagtggctga acaaagttgg ctggttcgac    1080

gaagaattta atcactgggg cggcgaagac gtcgaattcg gctacaggtt atttgcaaaa    1140

gggtgcttct ttagggttat cgacggtggt atggcctacc atcaagagcc accaggaaag    1200

gagaacgaaa cggatcgtga ggccggtaag tctatcactc ttaaaatagt aaaggagaaa    1260

gtgccctaca tctacaggaa gttgttgccg attgaggact cccacataaa ccgagtacca    1320

ttggtatcaa tttacatccc ggcctacaac tgtgctaact atattcaaag atgtgttgat    1380

tcagctttga atcaaacggt agttgatctc gaagtgtgca tttgcaacga cggtagtact    1440

gacaacacgc tggaagttat taacaagctg tatggtaata atccgcgtgt gcgtataatg    1500

tctaaaccca atggcggcat tgcgagtgca tccaacgcag cggtcagctt cgcaaagggt    1560

tattacatag gacagttgga cagcgacgat tacttagaac ccgacgcagt ggagttatgt    1620

ctcaaggaat ttcttaagga taagaccctt gcgtgcgttt acaccactaa tcgtaacgtc    1680

aacccagatg gctctttaat agccaatggc tataactggc cagagttcag tcgtgagaag    1740

ttgactacgg ccatgattgc tcatcacttc cggatgttta ccattcgtgc ttggcatctg    1800

acggatgggt tcaatgagaa gattgagaac gctgttgact acgacatgtt tctcaagctc    1860

agtgaagttg gtaaatttaa gcatctgaac aaaatatgtt ataatcgggt gttacacggc    1920

gataacacct caatcaagaa gcttggcata caaaagaaga atcatttcgt agttgtcaat    1980

cagtctctaa accgccaagg tataacttat tataactacg atgaatttga tgatctcgat    2040

gagagtcgga aatacatttt caacaagact gcagagtatc aagaagagat agatattctt    2100

aaagatattt ttattcagat gcttttttcc tggttttcta ttgcaaattt cgttcttacc    2160

ttttattatt tagcaggatc aatgaattta gttattaaac atggtgaggc cttattcatt    2220

ttttttaaat acctgatctt ttgtgacttg gcaagtttat tcattatttc catgggtaat    2280

agaccccagg gcgcgaaaca tttattcatt acctccatgg ttatactgtc tatatgtgcc    2340

acatattctc taatttgtgg gtttgttttt gctttcaagt cgttagcttc tggaacggaa    2400

tcccacaaaa tatttgtcga catcgttatc tcattgctct ccacctatgg cctatacttt    2460

ttctcatcac tgatgtacct agatccttgg cacatgttta catcatccat acaatacttt    2520

ttgacacttc ccgcctttac gtgtacttta cagatttttg ccttctgtaa tacacacgac    2580

gtttcctggg gtactaaagg ttccacacag gagtccaagc aattgtccaa ggccattgtc    2640

gttcaaggtc cagatgggaa acagattgtg gaaacagatt ggcctcagga agttgataag    2700

aagtttttgg aaataaaaag tcgtttgaaa gaaccagaat ttgaagaatc aagcggcaat    2760

gaaaaacaat ccaagaatga ttattataga gatataagaa ccagaattgt gatgatttgg    2820

atgctatcaa atctaatact gatcatgtct ataattcaag tctttacacc acaagatact    2880

gacaatggtt atttgatatt cattttatgg tctgtggccg ctttagctgc ctttagggtg    2940

gttggttcca tggccttttt gttcatgaaa tacttgcgta taatagtgag ttacagaaat    3000

aaagttgaag gtagcggctc atgggaagtc tctaaattag acttaccaaa tgttttccac    3060

aaaaagggct aa                                                        3072


<210> 5
<211> 3072
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of a polypeptide having chondroitin
      synthase activity (HHASA.Sc)

<400> 5
atgaacaccc tttcccaggc aattaaggct tataatagta atgattatca actagccctc      60

aagctgttcg aaaagtcggc agaaatctac ggcagaaaga tagttgagtt ccaaattacg     120

aagtgcaagg agaaactttc tgcgcaccca tccgttaaca gtgcgcatct ctcggttaac     180

aaagaagaga aggtgaatgt ttgcgacagt ccattagaca tagccactca attattgtta     240

tcgaatgtga aaaaactcgt ccttagtgat agcgagaaaa atacactaaa gaataaatgg     300

aagttgttga ctgaaaagaa gtctgagaac gcagaggtcc gggccgtagc tttagttccc     360

aaggactttc cgaaagattt agtgcttgcg ccgttaccag accatgtgaa cgattttacg     420

tggtataaga agcggaagaa acgcctagga atcaaaccag aacaccaaca cgttggcctc     480

tccattattg tgacaacgtt caaccgtcct gccatcctca gcatcaccct ggcttgcctc     540

gtcaatcaaa agacccatta tccttttgag gtgatcgtga ccgacgatgg ttctcaagag     600

gatttatcgc ctataatccg tcaatatgag aacaagctag acatccgtta tgttcggcaa     660

aaggacaacg gttttcaggc atcggccgca cgtaatatgg gcctacgtct agccaaatat     720

gacttcattg ggctccttga ttgtgatatg gctcccaacc ctttgtgggt acactcatac     780

gttgcggaac tattagagga cgatgatttg accataatag gccccaggaa gtacattgac     840

acgcaacaca tagatcccaa ggatttcctt aataacgcct ctctgttaga gtcgttgcca     900

gaggttaaga ccaataattc cgtcgcggct aagggcgagg ggaccgtatc tttagactgg     960

cgtttggaac aatttgagaa gaccgagaac ttgaggctat ccgatagccc tttccgattc    1020

ttcgcagctg ggaatgtggc tttcgccaag aagtggctta acaagtcagg attcttcgac    1080

gaggaattca atcactgggg aggtgaagat gtagagttcg gttatcgtct gtttcggtac    1140

ggttcgttct tcaaaactat agacggcatc atggcctatc atcaggaacc gccaggtaaa    1200

gaaaacgaaa ctgacagaga agcgggcaag aacattaccc tcgatataat gagggagaag    1260

gtgccttaca tctaccgtaa actcctgcct atagaagaca gtcatatcaa ccgagtacca    1320

ttggtatcaa tttacatccc ggcctacaac tgtgctaact atattcaaag atgtgttgat    1380

tcagctttga atcaaacggt agttgatctc gaagtgtgca tttgcaacga cggtagtact    1440

gacaacacgc tggaagttat taacaagctg tatggtaata atccgcgtgt gcgtataatg    1500

tctaaaccca atggcggcat tgcgagtgca tccaacgcag cggtcagctt cgcaaagggt    1560

tattacatag gacagttgga cagcgacgat tacttagaac ccgacgcagt ggagttatgt    1620

ctcaaggaat ttcttaagga taagaccctt gcgtgcgttt acaccactaa tcgtaacgtc    1680

aacccagatg gctctttaat agccaatggc tataactggc cagagttcag tcgtgagaag    1740

ttgactacgg ccatgattgc tcatcacttc cggatgttta ccattcgtgc ttggcatctg    1800

acggatgggt tcaatgagaa gattgagaac gctgttgact acgacatgtt tctcaagctc    1860

agtgaagttg gtaaatttaa gcatctgaac aaaatatgtt ataatcgggt gttacacggc    1920

gataacacct caatcaagaa gcttggcata caaaagaaga atcatttcgt agttgtcaat    1980

cagtctctaa accgccaagg tataacttat tataactacg atgaatttga tgatctcgat    2040

gagagtcgga aatacatttt caacaagact gcagagtatc aagaagagat agatattctt    2100

aaagatattt ttattcagat gcttttttcc tggttttcta ttgcaaattt cgttcttacc    2160

ttttattatt tagcaggatc aatgaattta gttattaaac atggtgaggc cttattcatt    2220

ttttttaaat acctgatctt ttgtgacttg gcaagtttat tcattatttc catgggtaat    2280

agaccccagg gcgcgaaaca tttattcatt acctccatgg ttatactgtc tatatgtgcc    2340

acatattctc taatttgtgg gtttgttttt gctttcaagt cgttagcttc tggaacggaa    2400

tcccacaaaa tatttgtcga catcgttatc tcattgctct ccacctatgg cctatacttt    2460

ttctcatcac tgatgtacct agatccttgg cacatgttta catcatccat acaatacttt    2520

ttgacacttc ccgcctttac gtgtacttta cagatttttg ccttctgtaa tacacacgac    2580

gtttcctggg gtactaaagg ttccacacag gagtccaagc aattgtccaa ggccattgtc    2640

gttcaaggtc cagatgggaa acagattgtg gaaacagatt ggcctcagga agttgataag    2700

aagtttttgg aaataaaaag tcgtttgaaa gaaccagaat ttgaagaatc aagcggcaat    2760

gaaaaacaat ccaagaatga ttattataga gatataagaa ccagaattgt gatgatttgg    2820

atgctatcaa atctaatact gatcatgtct ataattcaag tctttacacc acaagatact    2880

gacaatggtt atttgatatt cattttatgg tctgtggccg ctttagctgc ctttagggtg    2940

gttggttcca tggccttttt gttcatgaaa tacttgcgta taatagtgag ttacagaaat    3000

aaagttgaag gtagcggctc atgggaagtc tctaaattag acttaccaaa tgttttccac    3060

aaaaagggct aa                                                        3072


<210> 6
<211> 1719
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS1-Vir)

<400> 6
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aagggtggaa tgatgttagg ttggctgtaa ttattgccgg ctaccgtgag     300

gacccgtata tgttccaaaa gtgtcttgaa agtgtgcgtg actcagacta tgggaatgta     360

gctagactaa tatgcgttat tgacggcgat gaagacgacg acatgaggat ggctgcagtg     420

tacaaggcta tctataacga caacatcaag aaacctgagt ttgtcctctg tgagagtgac     480

gataaggagg gtgagagaat agatagcgat ttcagccgtg atatctgcgt gctgcaaccg     540

catcgcggaa agcgtgaatg tttgtacaca gggttccaat tggcaaagat ggacccctca     600

gttaatgccg tcgtcctaat cgacagtgac actgtgttag aaaaggacgc gattctcgaa     660

gtagtatacc cgctggcatg cgatccagaa atacaggctg tagcaggcga atgcaaaata     720

tggaatactg acacactgtt gagtttgctg gtagcctggc gatattacag cgcattttgc     780

gtagagcgta gcgcccaatc attcttcagg acagtacaat gcgtcggagg acctctcggc     840

gcctacaaga ttgatataat taaggaaatc aaggacccat ggatcagcca acgtttcctt     900

ggccaaaagt gcacatacgg cgacgataga cgactcacta atgaaatact aatgaggggt     960

aagaaagtag ttttcacccc attcgctgtt ggctggggat ggttcgacga ggagttcaca    1020

cactggggtg gccgttacat tgtacagcaa acacggtggt ccaagtcgtg gtgtagggag    1080

atatggtata cactgtttgc agcatggaag catggacttt cgggcatttg gctcgcattc    1140

gagtgcttat accagattac ttatttcttc ctggtgattt acctattctc ccgtttggct    1200

gttgaggctg acccacgggc gcaaacggcc accgtcattg tttcgaccac agttgcgctt    1260

attaagtgcg gttactttag cttcagagct aaagacatta gggccttcta tttcgtcctc    1320

tacacgttcg tttacttctt ctgcatgatt ccggcacgaa taactgcgat gatgaccctg    1380

tgggacatag gttggggaac caggggagga aatgagaagc cttccgtagg caccagagtt    1440

gctttgtggg ccaagcaata tttgattgct tacatgtggt gggccgctgt cgtcggtgct    1500

ggcgtgtact ccatcgttca taattggatg tttgactgga attcactttc ctacaggttc    1560

gcactggtag gcatctgttc gtatatagtt ttcattgtaa tagtgctggt agtctacttt    1620

acaggaaaga tcacgacctg gaacttcacg aagctacaga aagaattgat cgaggaccgc    1680

gtactgtacg acgcaacgac caatgcccag tcggtataa                           1719


<210> 7
<211> 1716
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS2-Vir)

<400> 7
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aagggtggaa tgatgttagg ttggctgtaa ttattgccgg ctaccgtgag     300

gacccgtata tgttccaaaa gtgtcttgaa agtgtgcgtg actcagacta tgggaatgta     360

gctagactaa tatgcgttat tgacggcgat gaagacgacg acatgaggat ggctgcagtg     420

tacaaggcta tctataacga caacatcaag aaacctgagt ttgtcctctg tgagagtgac     480

gataaggagg gtgagagaat agatagcgat ttcagccgtg atatctgcgt gctgcaaccg     540

catcgcggaa agcgtgaatg tttgtacaca gggttccaat tggcaaagat ggacccctca     600

gttaatgccg tcgtcctaat cgacagtgac actgtgttag aaaaggacgc gattctcgaa     660

gtagtatacc cgctggcatg cgatccagaa atacaggctg tagcaggcga atgcaaaata     720

tggaatactg acacactgtt gagtttgctg gtagcctggc gatattacag cgcattttgc     780

gtagagcgta gcgcccaatc attcttcagg acagtacaat gcgtcggagg acctctcggc     840

gcctacaaga ttgatataat taaggaaatc aaggacccat ggatcagcca acgtttcctt     900

ggccaaaagt gcacatacgg cgacgataga cgactcacta atgaaatact aatgaggggt     960

aagaaagtag ttttcacccc attcgctgtt ggctggctac acggtgagaa tacgtctatc    1020

aagaagttac gttacattgt acagcaaaca cggtggtcca agtcgtggtg tagggagata    1080

tggtatacac tgtttgcagc atggaagcat ggactttcgg gcatttggct cgcattcgag    1140

tgcttatacc agattactta tttcttcctg gtgatttacc tattctcccg tttggctgtt    1200

gaggctgacc cacgggcgca aacggccacc gtcattgttt cgaccacagt tgcgcttatt    1260

aagtgcggtt actttagctt cagagctaaa gacattaggg ccttctattt cgtcctctac    1320

acgttcgttt acttcttctg catgattccg gcacgaataa ctgcgatgat gaccctgtgg    1380

gacataggtt ggggaaccag gggaggaaat gagaagcctt ccgtaggcac cagagttgct    1440

ttgtgggcca agcaatattt gattgcttac atgtggtggg ccgctgtcgt cggtgctggc    1500

gtgtactcca tcgttcataa ttggatgttt gactggaatt cactttccta caggttcgca    1560

ctggtaggca tctgttcgta tatagttttc attgtaatag tgctggtagt ctactttaca    1620

ggaaagatca cgacctggaa cttcacgaag ctacagaaag aattgatcga ggaccgcgta    1680

ctgtacgacg caacgaccaa tgcccagtcg gtataa                              1716


<210> 8
<211> 1719
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS3-Vir)

<400> 8
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aagggtggaa tgatgttagg ttggctgtaa ttattgccgg ctaccgtgag     300

gacccgtata tgttccaaaa gtgtcttgaa agtgtgcgtg actcagacta tgggaatgta     360

gctagactaa tatgcgttat tgacggcgat gaagacgacg acatgaggat ggctgcagtg     420

tacaaggcta tctataacga caacatcaag aaacctgagt ttgtcctctg tgagagtgac     480

gataaggagg gtgagagaat agatagcgat ttcagccgtg atatctgcgt gctgcaaccg     540

catcgcggaa agcgtgaatg tttgtacaca gggttccaat tggcaaagat ggacccctca     600

gttaatgccg tcgtcctaat cgacagtgac actgtgttag aaaaggacgc gattctcgaa     660

gtagtatacc cgctggcatg cgatccagaa atacaggctg tagcaggcga atgcaaaata     720

tggaatactg acacactgtt gagtttgctg gtagcctggc gatattacag cgcattttgc     780

gtagagcgta gcgcccaatc attcttcagg acagtacaat gcgtcggagg acctctcggc     840

gcctacaaga ttgatataat taaggaaatc aaggacccat ggatcagcca acgtttcctt     900

ggccaaaagt gcacatacgg cgacgataga cgactcacta atgaaatact aatgaggggt     960

aagaaagtag ttttcacccc attcgctgtt ggctggcaca tggcatggtc cgacaaggac    1020

gacgcaatcg accgttacat tgtacagcaa acacggtggt ccaagtcgtg gtgtagggag    1080

atatggtata cactgtttgc agcatggaag catggacttt cgggcatttg gctcgcattc    1140

gagtgcttat accagattac ttatttcttc ctggtgattt acctattctc ccgtttggct    1200

gttgaggctg acccacgggc gcaaacggcc accgtcattg tttcgaccac agttgcgctt    1260

attaagtgcg gttactttag cttcagagct aaagacatta gggccttcta tttcgtcctc    1320

tacacgttcg tttacttctt ctgcatgatt ccggcacgaa taactgcgat gatgaccctg    1380

tgggacatag gttggggaac caggggagga aatgagaagc cttccgtagg caccagagtt    1440

gctttgtggg ccaagcaata tttgattgct tacatgtggt gggccgctgt cgtcggtgct    1500

ggcgtgtact ccatcgttca taattggatg tttgactgga attcactttc ctacaggttc    1560

gcactggtag gcatctgttc gtatatagtt ttcattgtaa tagtgctggt agtctacttt    1620

acaggaaaga tcacgacctg gaacttcacg aagctacaga aagaattgat cgaggaccgc    1680

gtactgtacg acgcaacgac caatgcccag tcggtataa                           1719


<210> 9
<211> 1713
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS4-Vir)

<400> 9
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aagggtggaa tgatgttagg ttggctgtaa ttattgccgg ctaccgtgag     300

gacccgtata tgttccaaaa gtgtcttgaa agtgtgcgtg actcagacta tgggaatgta     360

gctagactaa tatgcgttat tgacggcgat gaagacgacg acatgaggat ggctgcagtg     420

tacaaggcta tctataacga caacatcaag aaacctgagt ttgtcctctg tgagagtgac     480

gataaggagg gtgagagaat agatagcgat ttcagccgtg atatctgcgt gctgcaaccg     540

catcgcggaa agcgtgaatg tttgtacaca gggttccaat tggcaaagat ggacccctca     600

gttaatgccg tcgtcctaat cgacagtgac actgtgttag aaaaggacgc gattctcgaa     660

gtagtatacc cgctggcatg cgatccagaa atacaggctg tagcaggcga atgcaaaata     720

tggaatactg acacactgtt gagtttgctg gtagcctggc gatattacag cgcattttgc     780

gtagagcgta gcgcccaatc attcttcagg acagtacaat gcgtcggagg acctctcggc     840

gcctacaaga ttgatataat taaggaaatc aaggacccat ggatcagcca acgtttcctt     900

ggccaaaagt gcacatacgg cgacgataga cgactcacta atgaaatact aatgaggggt     960

aagaaagtag ttttcacccc attcgctgtt ggctggttcg acgaggagtt cacacactgg    1020

ggtggccgtt acattgtaca gcaaacacgg tggtccaagt cgtggtgtag ggagatatgg    1080

tatacactgt ttgcagcatg gaagcatgga ctttcgggca tttggctcgc attcgagtgc    1140

ttataccaga ttacttattt cttcctggtg atttacctat tctcccgttt ggctgttgag    1200

gctgacccac gggcgcaaac ggccaccgtc attgtttcga ccacagttgc gcttattaag    1260

tgcggttact ttagcttcag agctaaagac attagggcct tctatttcgt cctctacacg    1320

ttcgtttact tcttctgcat gattccggca cgaataactg cgatgatgac cctgtgggac    1380

ataggttggg gaaccagggg aggaaatgag aagccttccg taggcaccag agttgctttg    1440

tgggccaagc aatatttgat tgcttacatg tggtgggccg ctgtcgtcgg tgctggcgtg    1500

tactccatcg ttcataattg gatgtttgac tggaattcac tttcctacag gttcgcactg    1560

gtaggcatct gttcgtatat agttttcatt gtaatagtgc tggtagtcta ctttacagga    1620

aagatcacga cctggaactt cacgaagcta cagaaagaat tgatcgagga ccgcgtactg    1680

tacgacgcaa cgaccaatgc ccagtcggta taa                                 1713


<210> 10
<211> 2079
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS5-Vir)

<400> 10
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aatccattca ccatccaatt tcgaaaacga ctcaccccga cacagaaaat     300

gcaggtgact caacattgtt gtgcccgccc atggatggta tggacgacat attagtcgtt     360

atgaagacag gtgtcacaga ggctaaggaa aaggtgccag tacattttca gacaacgctg     420

aggtgtgtgc cgcactacgt tatctatagc gacttcgaag aagagataga aggtgtaaag     480

atttacgacg tcttgcaagg aatggacccc gatgttatga cgcaggttcc ggacttcgat     540

ctttacaatc gtattaagaa gttagggcgt cagggccttg cggagaacga cttcgcggac     600

gaagcgaact ctgcggtggg taagcctaat aaccctggtt ggaagttaga taaatggaag     660

ttcttaccta tgatcattga ggctctgaga tacaaaccaa aggctaagtg gtatgttttc     720

atggaagcag acacttatat atcttggccg actttattag cctggctaaa acacttcaac     780

cacaagaagc cgtggtatct tggcactgag acacagatag ccgatgtgat tttcgctcat     840

ggtggttcag gattcatgat tagtcatgcc gcgcttaagc ttgctgctga agaatatacc     900

gcacgtcgta ctgagttgca ccactacaca gacggtcact gggcaggaga ctgcgtatta     960

ggtaaagttc ttgctgacgc aggtgtgaac ttgcatttct cctggccaat tttacagaat    1020

tccaatctgg gcgaactgga tgagttcaac gttgacttat acaggcaacc ttggtgcttt    1080

ccagctgccg ctttccacca cttgaacgct cagaagatcc aggacttatg gtcttacgag    1140

cagaaaaggt ggcaggacaa ggacaagagg gttctgttac atagcgacgt cttcagggac    1200

ctattatatc cggatatagc attaaaaccc gcgaggatcg gttgggacaa cctgagtgca    1260

gacgaacagt ctacggcctc tagtttcgag gaatgcaggc aaatttgtga tcaattagac    1320

gattgtaccc agtttagttt cagggacaaa tcctgtttta catcaagaac tccacgtttg    1380

ggcgcagcca atccaaatac agttagcgga tggatggttg atcgtatccg tgcgaatatg    1440

gagaagtctg gactgtttgc agcatggaag catggacttt cgggcatttg gctcgcattc    1500

gagtgcttat accagattac ttatttcttc ctggtgattt acctattctc ccgtttggct    1560

gttgaggctg acccacgggc gcaaacggcc accgtcattg tttcgaccac agttgcgctt    1620

attaagtgcg gttactttag cttcagagct aaagacatta gggccttcta tttcgtcctc    1680

tacacgttcg tttacttctt ctgcatgatt ccggcacgaa taactgcgat gatgaccctg    1740

tgggacatag gttggggaac caggggagga aatgagaagc cttccgtagg caccagagtt    1800

gctttgtggg ccaagcaata tttgattgct tacatgtggt gggccgctgt cgtcggtgct    1860

ggcgtgtact ccatcgttca taattggatg tttgactgga attcactttc ctacaggttc    1920

gcactggtag gcatctgttc gtatatagtt ttcattgtaa tagtgctggt agtctacttt    1980

acaggaaaga tcacgacctg gaacttcacg aagctacaga aagaattgat cgaggaccgc    2040

gtactgtacg acgcaacgac caatgcccag tcggtataa                           2079


<210> 11
<211> 2733
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS6-Vir)

<400> 11
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aattagacat tgcaacacag ttattactat cgaatgttaa gaaattgacc     300

ttaagcgagt ccgaaaagaa cagcttaaag aataagtgga agagtataac aggcaagaag     360

tccgagaatg ctgaaattag gaaggttgag ttagtcccaa aggattttcc caaagactta     420

gttttagcgc cactaccaga ccatgtgaac gattttacct ggtacaagaa tagaaagaag     480

agcctgggca taaagcctgt gaacaagaac atcgggttgt caatcataat cccaactttc     540

aatcgtagta ggatattaga cattaccctg gcgtgtctag ttaatcagaa aactaactat     600

ccgtttgagg tggttgttgc agatgatggg tcgaaggaaa atctattgac tatagttcag     660

aaatacgagc agaaactaga cattaagtat gtgagacaga aggactatgg gtatcagctg     720

tgcgccgtta gaaaccttgg tctaaggaca gcgaagtatg actttgtctc tatcttggat     780

tgcgacatgg ccccgcagca gctatgggtt cactcttacc ttacagagtt actggaagac     840

aacgacatcg tcttgatcgg gccaaggaaa tacgttgata cccacaacat cacggctgag     900

cagtttctga acgacccata tttaattgag agtttaccgg aaaccgccac aaacaataat     960

ccatcgatta ccagtaaggg taacatctca ttagattgga gattagaaca ttttaagaag    1020

acagacaacc taagactatg cgactccccg ttcaggtatt tctcatgcgg aaatgtggcc    1080

ttctccaaag agtggctgaa caaagttggc tggttcgacg aagaatttaa tcactggggc    1140

ggcgaagacg tcgaattcgg ctacaggtta tttgcaaaag ggtgcttctt tagggttatc    1200

gacggtggta tggcctacca tcaagagcca ccaggaaagg agaacgaaac ggatcgtgag    1260

gccggtaagt ctatcactct taaaatagta aaggagaaag tgccctacat ctacaggaag    1320

ttgttgccga ttgaggactc ccacatacac cgtataccgc ttgtgagcat atacattcca    1380

gcgtacaact gcgccaatta tattcaaagg tgtgtagata gcgcgttgaa tcaaacagtg    1440

gtagatttgg aagtttgtat atgtaacgac ggaagtactg acaatacttt agaggtgatt    1500

aacaagctgt atggcaacaa cccgcgtgtc aggataatga gcaagcccaa tggtggaatt    1560

gcttccgcgt ctaacgctgc cgtttcattc gcgaaaggct actacattgg ccagttggac    1620

tcggatgatt acttggaacc tgacgcagtg gagctttgtt taaaggagtt cttgaaggac    1680

aaaacactag cctgtgtata tacaacgaac agaaatgtta atcctgacgg ttccctaatc    1740

gctaacggat acaattggcc tgagttcagc agggagaagc tgaccactgc tatgatcgcc    1800

caccatttca ggatgttcac aatcagggct tggcatttaa cagatggttt taatgagaaa    1860

atagagaacg cagtagacta cgatatgttt ctgaagttat cagaggtcgg gaaattcaaa    1920

cacttgaaca aaatttgtta caatagggta ttacacggtg acaacaccag tattaagaat    1980

cttgacaccc aaaagaagaa ccacttcgta gtagtgaacc agtctctgaa cagacaaagg    2040

gtgtcgaatt ataactacga tgagtttgat aacctggacg agagccgtaa gtacatattc    2100

aacaagctgt ttgcagcatg gaagcatgga ctttcgggca tttggctcgc attcgagtgc    2160

ttataccaga ttacttattt cttcctggtg atttacctat tctcccgttt ggctgttgag    2220

gctgacccac gggcgcaaac ggccaccgtc attgtttcga ccacagttgc gcttattaag    2280

tgcggttact ttagcttcag agctaaagac attagggcct tctatttcgt cctctacacg    2340

ttcgtttact tcttctgcat gattccggca cgaataactg cgatgatgac cctgtgggac    2400

ataggttggg gaaccagggg aggaaatgag aagccttccg taggcaccag agttgctttg    2460

tgggccaagc aatatttgat tgcttacatg tggtgggccg ctgtcgtcgg tgctggcgtg    2520

tactccatcg ttcataattg gatgtttgac tggaattcac tttcctacag gttcgcactg    2580

gtaggcatct gttcgtatat agttttcatt gtaatagtgc tggtagtcta ctttacagga    2640

aagatcacga cctggaactt cacgaagcta cagaaagaat tgatcgagga ccgcgtactg    2700

tacgacgcaa cgaccaatgc ccagtcggta taa                                 2733


<210> 12
<211> 2112
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS7-Vir)

<400> 12
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aaatcccaac tttcaatcgt agtaggatat tagacattac cctggcgtgt     300

ctagttaatc agaaaactaa ctatccgttt gaggtggttg ttgcagatga tgggtcgaag     360

gaaaatctat tgactatagt tcagaaatac gagcagaaac tagacattaa gtatgtgaga     420

cagaaggact atgggtatca gctgtgcgcc gttagaaacc ttggtctaag gacagcgaag     480

tatgactttg tctctatctt ggattgcgac atggccccgc agcagctatg ggttcactct     540

taccttacag agttactgga agacaacgac atcgtcttga tcgggccaag gaaatacgtt     600

gatacccaca acatcacggc tgagcagttt ctgaacgacc catatttaat tgagagttta     660

ccggaaaccg ccacaaacaa taatccatcg attaccagta agggtaacat ctcattagat     720

tggagattag aacattttaa gaagacagac aacctaagac tatgcgactc cccgttcagg     780

tatttctcat gcggaaatgt ggccttctcc aaagagtggc tgaacaaagt tggctggttc     840

gacgaagaat ttaatcactg gggcggcgaa gacgtcgaat tcggctacag gttatttgca     900

aaagggtgct tctttagggt tatcgacggt ggtatggcct accatcaaga gccaccagga     960

aaggagaacg aaacggatcg tgaggccggt aagtctatca ctcttaaaat agtaaaggag    1020

aaagtgccct acatctacag gaagttgttg ccgattgagg actcccacat acaccgtata    1080

ccgcttgtga gcatatacat tccagcgtac aactgcgcca attatattca aaggtgtgta    1140

gatagcgcgt tgaatcaaac agtggtagat ttggaagttt gtatatgtaa cgacggaagt    1200

actgacaata ctttagaggt gattaacaag ctgtatggca acaacccgcg tgtcaggata    1260

atgagcaagc ccaatggtgg aattgcttcc gcgtctaacg ctgccgtttc attcgcgaaa    1320

ggctactaca ttggccagtt ggactcggat gattacttgg aacctgacgc agtggagctt    1380

tgtttaaagg agttcttgaa ggacaaaaca ctagcctgtg tatatacaac gaacagaaat    1440

gttaatcctg acggttccct aatcgctaac ggatacaatt ggcctctgtt tgcagcatgg    1500

aagcatggac tttcgggcat ttggctcgca ttcgagtgct tataccagat tacttatttc    1560

ttcctggtga tttacctatt ctcccgtttg gctgttgagg ctgacccacg ggcgcaaacg    1620

gccaccgtca ttgtttcgac cacagttgcg cttattaagt gcggttactt tagcttcaga    1680

gctaaagaca ttagggcctt ctatttcgtc ctctacacgt tcgtttactt cttctgcatg    1740

attccggcac gaataactgc gatgatgacc ctgtgggaca taggttgggg aaccagggga    1800

ggaaatgaga agccttccgt aggcaccaga gttgctttgt gggccaagca atatttgatt    1860

gcttacatgt ggtgggccgc tgtcgtcggt gctggcgtgt actccatcgt tcataattgg    1920

atgtttgact ggaattcact ttcctacagg ttcgcactgg taggcatctg ttcgtatata    1980

gttttcattg taatagtgct ggtagtctac tttacaggaa agatcacgac ctggaacttc    2040

acgaagctac agaaagaatt gatcgaggac cgcgtactgt acgacgcaac gaccaatgcc    2100

cagtcggtat aa                                                        2112


<210> 13
<211> 1710
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS8-Vir)

<400> 13
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aagggtggaa tgatgttagg ttggctgtaa ttattgccgg ctaccgtgag     300

gacccgtata tgttccaaaa gtgtcttgaa agtgtgcgtg actcagacta tgggaatgta     360

gctagactaa tatgcgttat tgacggcgat gaagacgacg acatgaggat ggctgcagtg     420

tacaaggcta tctataacga caacatcaag aaacctgagt ttgtcctctg tgagagtgac     480

gataaggagg gtgagagaat agatagcgat ttcagccgtg atatctgcgt gctgcaaccg     540

catcgcggaa agcgtgaatg tttgtacaca gggttccaat tggcaaagat ggacccctca     600

gttaatgccg tcgtcctaat cgacagtgac actgtgttag aaaaggacgc gattctcgaa     660

gtagtatacc cgctggcatg cgatccagaa atacaggctg tagcaggcga atgcaaaata     720

tggaatactg acacactgtt gagtttgctg gtagcctggc gatattacag cgcattttgc     780

gtagagcgta gcgcccaatc attcttcagg acagtacaat gcgtcagact atgcgactcc     840

ccgttcaggt atttctcatg cggaaatgtg gccttctcca aagagtggct gaacaaagtt     900

ggctggttcg acgaagaatt taatcactgg ggcggcgaag acgtcgaatt cggctacagg     960

ttaaagaaag tagttttcac cccattcgct gttggctggt ccgacagccc gacgaacgtc    1020

ttccgttaca ttgtacagca aacacggtgg tccaagtcgt ggtgtaggga gatatggtat    1080

acactgtttg cagcatggaa gcatggactt tcgggcattt ggctcgcatt cgagtgctta    1140

taccagatta cttatttctt cctggtgatt tacctattct cccgtttggc tgttgaggct    1200

gacccacggg cgcaaacggc caccgtcatt gtttcgacca cagttgcgct tattaagtgc    1260

ggttacttta gcttcagagc taaagacatt agggccttct atttcgtcct ctacacgttc    1320

gtttacttct tctgcatgat tccggcacga ataactgcga tgatgaccct gtgggacata    1380

ggttggggaa ccaggggagg aaatgagaag ccttccgtag gcaccagagt tgctttgtgg    1440

gccaagcaat atttgattgc ttacatgtgg tgggccgctg tcgtcggtgc tggcgtgtac    1500

tccatcgttc ataattggat gtttgactgg aattcacttt cctacaggtt cgcactggta    1560

ggcatctgtt cgtatatagt tttcattgta atagtgctgg tagtctactt tacaggaaag    1620

atcacgacct ggaacttcac gaagctacag aaagaattga tcgaggaccg cgtactgtac    1680

gacgcaacga ccaatgccca gtcggtataa                                     1710


<210> 14
<211> 2499
<212> DNA
<213> other sequences


<220> 
<223> a nucleic acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS9-Vir)

<400> 14
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aacacattgg taagtgtcta agggaaatgt atacgactca tgaggacgtg     300

gaagtaggaa gatgcgttag gagattcgct ggagtacagt gtgtttggtc ttacgagatg     360

caacagttat tctacgagaa ctacgagcag aataagaagg gatacatccg tgatctgcac     420

aactccaaaa ttcaccaagc aataacgctg catcctaaca agaatccgcc ctatcagtat     480

aggttgcact cttacatgtt gagtagaaag atatctgagc tacgtcatag aactattcag     540

ttgcacaggg agatagtact gatgtctaaa tactcaaaca cggagatcca taaggaagac     600

ctacagttgg gtataccacc ttcgttcatg agattccagc caagacagag ggaagaaatt     660

ttggagtggg agttcttgac tggtaaatac ttgtattctg ctgttgacgg tcaaccacct     720

aggagaggga tggactctgc acagcgtgag gctttagacg atatagtgat gcaagtaatg     780

gaaatgatca acgctaatgc aaagacacgt ggtcgtatca tagatttcaa agagatccag     840

tatggatatc gtcgtgtgaa cccaatgtac ggcgcggagt atattcttga cttattgttg     900

ctatacaaga aacataaggg taagaagatg actgtcccgg ttcgtaggca cgcgtatttg     960

caacagactt tctcgaaaat acagtttgta gagcatgagg aacttgacgc gcaagagtta    1020

gcgaaacgta taaaccaaga gtcggggagt ttatccttct taagtaattc ccttaagaag    1080

ttggttcctt tccagctgcc tggaagtaaa agtgagcaca aggagccaaa ggataagaaa    1140

atcaacattc ttatacctct ttccggcaga ttcgacatgt tcgttaggtt catgggtaac    1200

ttcgagaaga cctgcttaat tcctaaccag aatgttaagt tggtagtttt gttattcaat    1260

tctgacagta accccgacaa agcaaagcag gttgaactga tgagagacta taggattaag    1320

tacccaaaag cagatatgca gatactacct gtttccggag aattctcaag agccttggct    1380

ctggaagtag gcagctctca gtttaataat gagtctcttc tgttcttctg cgacgttgac    1440

ttagttttca cgacagagtt tctgcagaga tgtcgtgcaa acactgtact aggtcagcag    1500

atatatttcc ccattatttt cagtcagtac gatccaaaga ttgtttatag tggaaaagtt    1560

ccatctgaca accattttgc gtttactcaa aagacagggt tttggcgtaa ctacgggttc    1620

ggcataacat gtatctataa aggggacctg gtaagagttg gcggattcga cgtatctata    1680

cagggctggg gtttagaaga cgtcgatcta tttaataaag tagttcaggc aggtttgaag    1740

acattccgta gtcaagaggt aggcgttgta cacgtgcacc atccagtatt ttgcgaccca    1800

aacttagacc cgaagcaata taaaatgtgc ttgggttcca aggcatcgac ttacggttcc    1860

acgcagcaac tactgtttgc agcatggaag catggacttt cgggcatttg gctcgcattc    1920

gagtgcttat accagattac ttatttcttc ctggtgattt acctattctc ccgtttggct    1980

gttgaggctg acccacgggc gcaaacggcc accgtcattg tttcgaccac agttgcgctt    2040

attaagtgcg gttactttag cttcagagct aaagacatta gggccttcta tttcgtcctc    2100

tacacgttcg tttacttctt ctgcatgatt ccggcacgaa taactgcgat gatgaccctg    2160

tgggacatag gttggggaac caggggagga aatgagaagc cttccgtagg caccagagtt    2220

gctttgtggg ccaagcaata tttgattgct tacatgtggt gggccgctgt cgtcggtgct    2280

ggcgtgtact ccatcgttca taattggatg tttgactgga attcactttc ctacaggttc    2340

gcactggtag gcatctgttc gtatatagtt ttcattgtaa tagtgctggt agtctacttt    2400

acaggaaaga tcacgacctg gaacttcacg aagctacaga aagaattgat cgaggaccgc    2460

gtactgtacg acgcaacgac caatgcccag tcggtataa                           2499


<210> 15
<211> 3006
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS10-Vir)

<400> 15
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aaagagatag aaacttccta ttcgttggtg ttatgacagc tcagaagtac     300

ttacagacca gggcggttgc agcatataga acctggtcaa agacaattcc aggtaaggta     360

cagttcttca gctccgaggg ttctgacacc agcgtcccta tcccagtagt gcctttgcgt     420

ggagtggatg attcataccc acctcagaag aagtccttca tgatgcttaa gtatatgcac     480

gaccactatc tggacaaata cgagtggttc atgagagcag acgacgacgt ttacataaag     540

ggtgatagac tggagaattt cttgaggtca ctaaacagtt cagaaccact tttcctagga     600

cagacgggcc ttggtacgac agaggagatg ggtaagttgg cattggagcc aggggagaac     660

ttctgcatgg gtggccctgg tgtgattatg agtagggaag ttttaagaag aatggttccg     720

cacattggta agtgtctaag ggaaatgtat acgactcatg aggacgtgga agtaggaaga     780

tgcgttagga gattcgctgg agtacagtgt gtttggtctt acgagatgca acagttattc     840

tacgagaact acgagcagaa taagaaggga tacatccgtg atctgcacaa ctccaaaatt     900

caccaagcaa taacgctgca tcctaacaag aatccgccct atcagtatag gttgcactct     960

tacatgttga gtagaaagat atctgagcta cgtcatagaa ctattcagtt gcacagggag    1020

atagtactga tgtctaaata ctcaaacacg gagatccata aggaagacct acagttgggt    1080

ataccacctt cgttcatgag attccagcca agacagaggg aagaaatttt ggagtgggag    1140

ttcttgactg gtaaatactt gtattctgct gttgacggtc aaccacctag gagagggatg    1200

gactctgcac agcgtgaggc tttagacgat atagtgatgc aagtaatgga aatgatcaac    1260

gctaatgcaa agacacgtgg tcgtatcata gatttcaaag agatccagta tggatatcgt    1320

cgtgtgaacc caatgtacgg cgcggagtat attcttgact tattgttgct atacaagaaa    1380

cataagggta agaagatgac tgtcccggtt cgtaggcacg cgtatttgca acagactttc    1440

tcgaaaatac agtttgtaga gcatgaggaa cttgacgcgc aagagttagc gaaacgtata    1500

aaccaagagt cggggagttt atccttctta agtaattccc ttaagaagtt ggttcctttc    1560

cagctgcctg gaagtaaaag tgagcacaag gagccaaagg ataagaaaat caacattctt    1620

atacctcttt ccggcagatt cgacatgttc gttaggttca tgggtaactt cgagaagacc    1680

tgcttaattc ctaaccagaa tgttaagttg gtagttttgt tattcaattc tgacagtaac    1740

cccgacaaag caaagcaggt tgaactgatg agagactata ggattaagta cccaaaagca    1800

gatatgcaga tactacctgt ttccggagaa ttctcaagag ccttggctct ggaagtaggc    1860

agctctcagt ttaataatga gtctcttctg ttcttctgcg acgttgactt agttttcacg    1920

acagagtttc tgcagagatg tcgtgcaaac actgtactag gtcagcagat atatttcccc    1980

attattttca gtcagtacga tccaaagatt gtttatagtg gaaaagttcc atctgacaac    2040

cattttgcgt ttactcaaaa gacagggttt tggcgtaact acgggttcgg cataacatgt    2100

atctataaag gggacctggt aagagttggc ggattcgacg tatctataca gggctggggt    2160

ttagaagacg tcgatctatt taataaagta gttcaggcag gtttgaagac attccgtagt    2220

caagaggtag gcgttgtaca cgtgcaccat ccagtatttt gcgacccaaa cttagacccg    2280

aagcaatata aaatgtgctt gggttccaag gcatcgactt acggttccac gcagcaacta    2340

gcagagatgt ggttggagaa gaacgaccca tcttatagcc tgtttgcagc atggaagcat    2400

ggactttcgg gcatttggct cgcattcgag tgcttatacc agattactta tttcttcctg    2460

gtgatttacc tattctcccg tttggctgtt gaggctgacc cacgggcgca aacggccacc    2520

gtcattgttt cgaccacagt tgcgcttatt aagtgcggtt actttagctt cagagctaaa    2580

gacattaggg ccttctattt cgtcctctac acgttcgttt acttcttctg catgattccg    2640

gcacgaataa ctgcgatgat gaccctgtgg gacataggtt ggggaaccag gggaggaaat    2700

gagaagcctt ccgtaggcac cagagttgct ttgtgggcca agcaatattt gattgcttac    2760

atgtggtggg ccgctgtcgt cggtgctggc gtgtactcca tcgttcataa ttggatgttt    2820

gactggaatt cactttccta caggttcgca ctggtaggca tctgttcgta tatagttttc    2880

attgtaatag tgctggtagt ctactttaca ggaaagatca cgacctggaa cttcacgaag    2940

ctacagaaag aattgatcga ggaccgcgta ctgtacgacg caacgaccaa tgcccagtcg    3000

gtataa                                                               3006


<210> 16
<211> 1596
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS11-Vir)

<400> 16
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aaagagatag aaacttccta ttcgttggtg ttatgacagc tcagaagtac     300

ttacagacca gggcggttgc agcatataga acctggtcaa agacaattcc aggtaaggta     360

cagttcttca gctccgaggg ttctgacacc agcgtcccta tcccagtagt gcctttgcgt     420

ggagtggatg attcataccc acctcagaag aagtccttca tgatgcttaa gtatatgcac     480

gaccactatc tggacaaata cgagtggttc atgagagcag acgacgacgt ttacataaag     540

ggtgatagac tggagaattt cttgaggtca ctaaacagtt cagaaccact tttcctagga     600

cagacgggcc ttggtacgac agaggagatg ggtaagttgg cattggagcc aggggagaac     660

ttctgcatgg gtggccctgg tgtgattatg agtagggaag ttttaagaag aatggttccg     720

cacattggta agtgtctaag ggaaatgtat acgactcatg aggacgtgga agtaggaaga     780

tgcgttagga gattcgctgg agtacagtgt gtttggtctt acgagatgca acagttattc     840

tacgagaact acgagcagaa taagaaggga tacatccgtg atctgcacaa ctccaaaatt     900

caccaagcaa taacgctgca tcctaacaag aatccgccct atcagtatag gttgcactct     960

tacatgttgc tgtttgcagc atggaagcat ggactttcgg gcatttggct cgcattcgag    1020

tgcttatacc agattactta tttcttcctg gtgatttacc tattctcccg tttggctgtt    1080

gaggctgacc cacgggcgca aacggccacc gtcattgttt cgaccacagt tgcgcttatt    1140

aagtgcggtt actttagctt cagagctaaa gacattaggg ccttctattt cgtcctctac    1200

acgttcgttt acttcttctg catgattccg gcacgaataa ctgcgatgat gaccctgtgg    1260

gacataggtt ggggaaccag gggaggaaat gagaagcctt ccgtaggcac cagagttgct    1320

ttgtgggcca agcaatattt gattgcttac atgtggtggg ccgctgtcgt cggtgctggc    1380

gtgtactcca tcgttcataa ttggatgttt gactggaatt cactttccta caggttcgca    1440

ctggtaggca tctgttcgta tatagttttc attgtaatag tgctggtagt ctactttaca    1500

ggaaagatca cgacctggaa cttcacgaag ctacagaaag aattgatcga ggaccgcgta    1560

ctgtacgacg caacgaccaa tgcccagtcg gtataa                              1596


<210> 17
<211> 1662
<212> DNA
<213> other sequences


<220> 
<223> reencoded nucleic acid sequence of a polypeptide having
      chondroitin synthase activity (HCOS12-Vir)

<400> 17
atgggtaaga acatcattat tatggtttct tggtacacta ttattacatc caatctcatc      60

gcagtgggtg gcgcctcact catactagcc ccagctatta cgggctatgt ccttcactgg     120

aacattgccc tttcaacaat ttggggagtg tcggcctacg gaattttcgt gtttggtttc     180

tttcttgccc aggtattatt tagtgaactc aaccggaaaa ggctccggaa gtggatttcc     240

ctccgaccca aaaaggataa gaaaatcaac attcttatac ctctttccgg cagattcgac     300

atgttcgtta ggttcatggg taacttcgag aagacctgct taattcctaa ccagaatgtt     360

aagttggtag ttttgttatt caattctgac agtaaccccg acaaagcaaa gcaggttgaa     420

ctgatgagag actataggat taagtaccca aaagcagata tgcagatact acctgtttcc     480

ggagaattct caagagcctt ggctctggaa gtaggcagct ctcagtttaa taatgagtct     540

cttctgttct tctgcgacgt tgacttagtt ttcacgacag agtttctgca gagatgtcgt     600

gcaaacactg tactaggtca gcagatatat ttccccatta ttttcagtca gtacgatcca     660

aagattgttt atagtggaaa agttccatct gacaaccatt ttgcgtttac tcaaaagaca     720

gggttttggc gtaactacgg gttcggcata acatgtatct ataaagggga cctggtaaga     780

gttggcggat tcgacgtatc tatacagggc tggggtttag aagacgtcga tctatttaat     840

aaagtagttc aggcaggttt gaagacattc cgtagtcaag aggtaggcgt tgtacacgtg     900

caccatccag tattttgcga cccaaactta gacccgaagc aatataaaat gtgcttgggt     960

tccaaggcat cgacttacgg ttccacgcag caactagcag agatgtggtt ggagaagaac    1020

gacccatctt atagcctgtt tgcagcatgg aagcatggac tttcgggcat ttggctcgca    1080

ttcgagtgct tataccagat tacttatttc ttcctggtga tttacctatt ctcccgtttg    1140

gctgttgagg ctgacccacg ggcgcaaacg gccaccgtca ttgtttcgac cacagttgcg    1200

cttattaagt gcggttactt tagcttcaga gctaaagaca ttagggcctt ctatttcgtc    1260

ctctacacgt tcgtttactt cttctgcatg attccggcac gaataactgc gatgatgacc    1320

ctgtgggaca taggttgggg aaccagggga ggaaatgaga agccttccgt aggcaccaga    1380

gttgctttgt gggccaagca atatttgatt gcttacatgt ggtgggccgc tgtcgtcggt    1440

gctggcgtgt actccatcgt tcataattgg atgtttgact ggaattcact ttcctacagg    1500

ttcgcactgg taggcatctg ttcgtatata gttttcattg taatagtgct ggtagtctac    1560

tttacaggaa agatcacgac ctggaacttc acgaagctac agaaagaatt gatcgaggac    1620

cgcgtactgt acgacgcaac gaccaatgcc cagtcggtat aa                       1662


<210> 18
<211> 972
<212> PRT
<213> other sequences


<220> 
<223> an amino acid sequence of a polypeptide having a chondroitin
      synthase activity (HCOS-1)

<400> 18
Met Asn Thr Leu Ser Gln Ala Ile Lys Ala Tyr Asn Ser Asn Asp Tyr 
1               5                   10                  15      
Gln Leu Ala Leu Lys Leu Phe Glu Lys Ser Ala Glu Ile Tyr Gly Arg 
            20                  25                  30          
Lys Ile Val Glu Phe Gln Ile Thr Lys Cys Lys Glu Lys Leu Ser Ala 
        35                  40                  45              
His Pro Ser Val Asn Ser Ala His Leu Ser Val Asn Lys Glu Glu Lys 
    50                  55                  60                  
Val Asn Val Cys Asp Ser Pro Leu Asp Ile Ala Thr Gln Leu Leu Leu 
65                  70                  75                  80  
Ser Asn Val Lys Lys Leu Val Leu Ser Asp Ser Glu Lys Asn Thr Leu 
                85                  90                  95      
Lys Asn Lys Trp Lys Leu Leu Thr Glu Lys Lys Ser Glu Asn Ala Glu 
            100                 105                 110         
Val Arg Ala Val Ala Leu Val Pro Lys Asp Phe Pro Lys Asp Leu Val 
        115                 120                 125             
Leu Ala Pro Leu Pro Asp His Val Asn Asp Phe Thr Trp Tyr Lys Lys 
    130                 135                 140                 
Arg Lys Lys Arg Leu Gly Ile Lys Pro Glu His Gln His Val Gly Leu 
145                 150                 155                 160 
Ser Ile Ile Val Thr Thr Phe Asn Arg Pro Ala Ile Leu Ser Ile Thr 
                165                 170                 175     
Leu Ala Cys Leu Val Asn Gln Lys Thr His Tyr Pro Phe Glu Val Ile 
            180                 185                 190         
Val Thr Asp Asp Gly Ser Gln Glu Asp Leu Ser Pro Ile Ile Arg Gln 
        195                 200                 205             
Tyr Glu Asn Lys Leu Asp Ile Arg Tyr Val Arg Gln Lys Asp Tyr Gly 
    210                 215                 220                 
Tyr Gln Leu Cys Ala Val Arg Asn Leu Gly Leu Arg Thr Ala Lys Tyr 
225                 230                 235                 240 
Asp Phe Val Ser Ile Leu Asp Cys Asp Met Ala Pro Gln Gln Leu Trp 
                245                 250                 255     
Val His Ser Tyr Leu Thr Glu Leu Leu Glu Asp Asp Asp Leu Thr Ile 
            260                 265                 270         
Ile Gly Pro Arg Lys Tyr Ile Asp Thr Gln His Ile Asp Pro Lys Asp 
        275                 280                 285             
Phe Leu Asn Asn Ala Ser Leu Leu Glu Ser Leu Pro Glu Val Lys Thr 
    290                 295                 300                 
Asn Asn Ser Val Ala Ala Lys Gly Glu Gly Thr Val Ser Leu Asp Trp 
305                 310                 315                 320 
Arg Leu Glu Gln Phe Glu Lys Thr Glu Asn Leu Arg Leu Ser Asp Ser 
                325                 330                 335     
Pro Phe Arg Phe Phe Ala Ala Gly Asn Val Ala Phe Ala Lys Lys Trp 
            340                 345                 350         
Leu Asn Lys Ser Gly Phe Phe Asp Glu Glu Phe Asn His Trp Gly Gly 
        355                 360                 365             
Glu Asp Val Glu Phe Gly Tyr Arg Leu Phe Arg Tyr Gly Ser Phe Phe 
    370                 375                 380                 
Lys Thr Ile Asp Gly Ile Met Ala Tyr His Gln Glu Pro Pro Gly Lys 
385                 390                 395                 400 
Glu Asn Glu Thr Asp Arg Glu Ala Gly Lys Asn Ile Thr Leu Asp Ile 
                405                 410                 415     
Met Arg Glu Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile Glu 
            420                 425                 430         
Asp Ser His Ile Asn Arg Val Pro Leu Val Ser Ile Tyr Ile Pro Ala 
        435                 440                 445             
Tyr Asn Cys Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu Asn 
    450                 455                 460                 
Gln Thr Val Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser Thr 
465                 470                 475                 480 
Asp Asn Thr Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro Arg 
                485                 490                 495     
Val Arg Ile Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser Asn 
            500                 505                 510         
Ala Ala Val Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp Ser 
        515                 520                 525             
Asp Asp Tyr Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu Phe 
    530                 535                 540                 
Leu Lys Asp Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn Val 
545                 550                 555                 560 
Asn Pro Asp Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Glu Phe 
                565                 570                 575     
Ser Arg Glu Lys Leu Thr Thr Ala Met Ile Ala His His Phe Arg Met 
            580                 585                 590         
Phe Thr Ile Arg Ala Trp His Leu Thr Asp Gly Phe Asn Glu Lys Ile 
        595                 600                 605             
Glu Asn Ala Val Asp Tyr Asp Met Phe Leu Lys Leu Ser Glu Val Gly 
    610                 615                 620                 
Lys Phe Lys His Leu Asn Lys Ile Cys Tyr Asn Arg Val Leu His Gly 
625                 630                 635                 640 
Asp Asn Thr Ser Ile Lys Lys Leu Gly Ile Gln Lys Lys Asn His Phe 
                645                 650                 655     
Val Val Val Asn Gln Ser Leu Asn Arg Gln Gly Ile Thr Tyr Tyr Asn 
            660                 665                 670         
Tyr Asp Glu Phe Asp Asp Leu Asp Glu Ser Arg Lys Tyr Ile Phe Asn 
        675                 680                 685             
Lys Thr Ala Glu Tyr Gln Glu Glu Ile Asp Ile Leu Lys Asp Ile Lys 
    690                 695                 700                 
Ile Ile Gln Asn Lys Asp Ala Lys Ile Ala Val Ser Ile Phe Tyr Pro 
705                 710                 715                 720 
Asn Thr Leu Asn Gly Leu Val Lys Lys Leu Asn Asn Ile Ile Glu Tyr 
                725                 730                 735     
Asn Lys Asn Ile Phe Val Ile Val Leu His Val Asp Lys Asn His Leu 
            740                 745                 750         
Thr Pro Asp Ile Lys Lys Glu Ile Leu Ala Phe Tyr His Lys His Gln 
        755                 760                 765             
Val Asn Ile Leu Leu Asn Asn Asp Ile Ser Tyr Tyr Thr Ser Asn Arg 
    770                 775                 780                 
Leu Ile Lys Thr Glu Ala His Leu Ser Asn Ile Asn Lys Leu Ser Gln 
785                 790                 795                 800 
Leu Asn Leu Asn Cys Glu Tyr Ile Ile Phe Asp Asn His Asp Ser Leu 
                805                 810                 815     
Phe Val Lys Asn Asp Ser Tyr Ala Tyr Met Lys Lys Tyr Asp Val Gly 
            820                 825                 830         
Met Asn Phe Ser Ala Leu Thr His Asp Trp Ile Glu Lys Ile Asn Ala 
        835                 840                 845             
His Pro Pro Phe Lys Lys Leu Ile Lys Thr Tyr Phe Asn Asp Asn Asp 
    850                 855                 860                 
Leu Lys Ser Met Asn Val Lys Gly Ala Ser Gln Gly Met Phe Met Thr 
865                 870                 875                 880 
Tyr Ala Leu Ala His Glu Leu Leu Thr Ile Ile Lys Glu Val Ile Thr 
                885                 890                 895     
Ser Cys Gln Ser Ile Asp Ser Val Pro Glu Tyr Asn Thr Glu Asp Ile 
            900                 905                 910         
Trp Phe Gln Phe Ala Leu Leu Ile Leu Glu Lys Lys Thr Gly His Val 
        915                 920                 925             
Phe Asn Lys Thr Ser Thr Leu Thr Tyr Met Pro Trp Glu Arg Lys Leu 
    930                 935                 940                 
Gln Trp Thr Asn Glu Gln Ile Glu Ser Ala Lys Arg Gly Glu Asn Ile 
945                 950                 955                 960 
Pro Val Asn Lys Phe Ile Ile Asn Ser Ile Thr Leu 
                965                 970         

<210> 19
<211> 972
<212> PRT
<213> other sequences


<220> 
<223> an amino acid sequence of a polypeptide having a chondroitin
      synthase activity (HCOS1-2)

<400> 19
Met Asn Thr Leu Ser Gln Ala Ile Lys Ala Tyr Asn Ser Asn Asp Tyr 
1               5                   10                  15      
Gln Leu Ala Leu Lys Leu Phe Glu Lys Ser Ala Glu Ile Tyr Gly Arg 
            20                  25                  30          
Lys Ile Val Glu Phe Gln Ile Thr Lys Cys Lys Glu Lys Leu Ser Ala 
        35                  40                  45              
His Pro Ser Val Asn Ser Ala His Leu Ser Val Asn Lys Glu Glu Lys 
    50                  55                  60                  
Val Asn Val Cys Asp Ser Pro Leu Asp Ile Ala Thr Gln Leu Leu Leu 
65                  70                  75                  80  
Ser Asn Val Lys Lys Leu Val Leu Ser Asp Ser Glu Lys Asn Thr Leu 
                85                  90                  95      
Lys Asn Lys Trp Lys Leu Leu Thr Glu Lys Lys Ser Glu Asn Ala Glu 
            100                 105                 110         
Val Arg Ala Val Ala Leu Val Pro Lys Asp Phe Pro Lys Asp Leu Val 
        115                 120                 125             
Leu Ala Pro Leu Pro Asp His Val Asn Asp Phe Thr Trp Tyr Lys Lys 
    130                 135                 140                 
Arg Lys Lys Arg Leu Gly Ile Lys Pro Val Asn Lys Asn Ile Gly Leu 
145                 150                 155                 160 
Ser Ile Ile Ile Pro Thr Phe Asn Arg Ser Arg Ile Leu Asp Ile Thr 
                165                 170                 175     
Leu Ala Cys Leu Val Asn Gln Lys Thr His Tyr Pro Phe Glu Val Ile 
            180                 185                 190         
Val Thr Asp Asp Gly Ser Gln Glu Asp Leu Ser Pro Ile Ile Arg Gln 
        195                 200                 205             
Tyr Glu Asn Lys Leu Asp Ile Arg Tyr Val Arg Gln Lys Asp Tyr Gly 
    210                 215                 220                 
Tyr Gln Leu Cys Ala Val Arg Asn Leu Gly Leu Arg Thr Ala Lys Tyr 
225                 230                 235                 240 
Asp Phe Val Ser Ile Leu Asp Cys Asp Met Ala Pro Gln Gln Leu Trp 
                245                 250                 255     
Val His Ser Tyr Leu Thr Glu Leu Leu Glu Asp Asp Asp Leu Thr Ile 
            260                 265                 270         
Ile Gly Pro Arg Lys Tyr Ile Asp Thr Gln His Ile Asp Pro Lys Asp 
        275                 280                 285             
Phe Leu Asn Asn Ala Ser Leu Leu Glu Ser Leu Pro Glu Val Lys Thr 
    290                 295                 300                 
Asn Asn Ser Val Ala Ala Lys Gly Glu Gly Thr Val Ser Leu Asp Trp 
305                 310                 315                 320 
Arg Leu Glu Gln Phe Glu Lys Thr Glu Asn Leu Arg Leu Ser Asp Ser 
                325                 330                 335     
Pro Phe Arg Phe Phe Ser Cys Gly Asn Val Ala Phe Ser Lys Glu Trp 
            340                 345                 350         
Leu Asn Lys Val Gly Trp Phe Asp Glu Glu Phe Asn His Trp Gly Gly 
        355                 360                 365             
Glu Asp Val Glu Phe Gly Tyr Arg Leu Phe Arg Tyr Gly Ser Phe Phe 
    370                 375                 380                 
Lys Thr Ile Asp Gly Ile Met Ala Tyr His Gln Glu Pro Pro Gly Lys 
385                 390                 395                 400 
Glu Asn Glu Thr Asp Arg Glu Ala Gly Lys Asn Ile Thr Leu Asp Ile 
                405                 410                 415     
Met Arg Glu Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile Glu 
            420                 425                 430         
Asp Ser His Ile Asn Arg Val Pro Leu Val Ser Ile Tyr Ile Pro Ala 
        435                 440                 445             
Tyr Asn Cys Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu Asn 
    450                 455                 460                 
Gln Thr Val Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser Thr 
465                 470                 475                 480 
Asp Asn Thr Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro Arg 
                485                 490                 495     
Val Arg Ile Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser Asn 
            500                 505                 510         
Ala Ala Val Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp Ser 
        515                 520                 525             
Asp Asp Tyr Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu Phe 
    530                 535                 540                 
Leu Lys Asp Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn Val 
545                 550                 555                 560 
Asn Pro Asp Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Glu Phe 
                565                 570                 575     
Ser Arg Glu Lys Leu Thr Thr Ala Met Ile Ala His His Phe Arg Met 
            580                 585                 590         
Phe Thr Ile Arg Ala Trp His Leu Thr Asp Gly Phe Asn Glu Lys Ile 
        595                 600                 605             
Glu Asn Ala Val Asp Tyr Asp Met Phe Leu Lys Leu Ser Glu Val Gly 
    610                 615                 620                 
Lys Phe Lys His Leu Asn Lys Ile Cys Tyr Asn Arg Val Leu His Gly 
625                 630                 635                 640 
Asp Asn Thr Ser Ile Lys Lys Leu Gly Ile Gln Lys Lys Asn His Phe 
                645                 650                 655     
Val Val Val Asn Gln Ser Leu Asn Arg Gln Gly Ile Thr Tyr Tyr Asn 
            660                 665                 670         
Tyr Asp Glu Phe Asp Asp Leu Asp Glu Ser Arg Lys Tyr Ile Phe Asn 
        675                 680                 685             
Lys Thr Ala Glu Tyr Gln Glu Glu Ile Asp Ile Leu Lys Asp Ile Lys 
    690                 695                 700                 
Ile Ile Gln Asn Lys Asp Ala Lys Ile Ala Val Ser Ile Phe Tyr Pro 
705                 710                 715                 720 
Asn Thr Leu Asn Gly Leu Val Lys Lys Leu Asn Asn Ile Ile Glu Tyr 
                725                 730                 735     
Asn Lys Asn Ile Phe Val Ile Val Leu His Val Asp Lys Asn His Leu 
            740                 745                 750         
Thr Pro Asp Ile Lys Lys Glu Ile Leu Ala Phe Tyr His Lys His Gln 
        755                 760                 765             
Val Asn Ile Leu Leu Asn Asn Asp Ile Ser Tyr Tyr Thr Ser Asn Arg 
    770                 775                 780                 
Leu Ile Lys Thr Glu Ala His Leu Ser Asn Ile Asn Lys Leu Ser Gln 
785                 790                 795                 800 
Leu Asn Leu Asn Cys Glu Tyr Ile Ile Phe Asp Asn His Asp Ser Leu 
                805                 810                 815     
Phe Val Lys Asn Asp Ser Tyr Ala Tyr Met Lys Lys Tyr Asp Val Gly 
            820                 825                 830         
Met Asn Phe Ser Ala Leu Thr His Asp Trp Ile Glu Lys Ile Asn Ala 
        835                 840                 845             
His Pro Pro Phe Lys Lys Leu Ile Lys Thr Tyr Phe Asn Asp Asn Asp 
    850                 855                 860                 
Leu Lys Ser Met Asn Val Lys Gly Ala Ser Gln Gly Met Phe Met Thr 
865                 870                 875                 880 
Tyr Ala Leu Ala His Glu Leu Leu Thr Ile Ile Lys Glu Val Ile Thr 
                885                 890                 895     
Ser Cys Gln Ser Ile Asp Ser Val Pro Glu Tyr Asn Thr Glu Asp Ile 
            900                 905                 910         
Trp Phe Gln Phe Ala Leu Leu Ile Leu Glu Lys Lys Thr Gly His Val 
        915                 920                 925             
Phe Asn Lys Thr Ser Thr Leu Thr Tyr Met Pro Trp Glu Arg Lys Leu 
    930                 935                 940                 
Gln Trp Thr Asn Glu Gln Ile Glu Ser Ala Lys Arg Gly Glu Asn Ile 
945                 950                 955                 960 
Pro Val Asn Lys Phe Ile Ile Asn Ser Ile Thr Leu 
                965                 970         

<210> 20
<211> 972
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of a polypeptide having a chondroitin
      synthase activity (HCOS1-3)

<400> 20
Met Asn Thr Leu Ser Gln Ala Ile Lys Ala Tyr Asn Ser Asn Asp Tyr 
1               5                   10                  15      
Gln Leu Ala Leu Lys Leu Phe Glu Lys Ser Ala Glu Ile Tyr Gly Arg 
            20                  25                  30          
Lys Ile Val Glu Phe Gln Ile Thr Lys Cys Lys Glu Lys Leu Ser Ala 
        35                  40                  45              
His Pro Ser Val Asn Ser Ala His Leu Ser Val Asn Lys Glu Glu Lys 
    50                  55                  60                  
Val Asn Val Cys Asp Ser Pro Leu Asp Ile Ala Thr Gln Leu Leu Leu 
65                  70                  75                  80  
Ser Asn Val Lys Lys Leu Val Leu Ser Asp Ser Glu Lys Asn Thr Leu 
                85                  90                  95      
Lys Asn Lys Trp Lys Leu Leu Thr Glu Lys Lys Ser Glu Asn Ala Glu 
            100                 105                 110         
Val Arg Ala Val Ala Leu Val Pro Lys Asp Phe Pro Lys Asp Leu Val 
        115                 120                 125             
Leu Ala Pro Leu Pro Asp His Val Asn Asp Phe Thr Trp Tyr Lys Asn 
    130                 135                 140                 
Arg Lys Lys Ser Leu Gly Ile Lys Pro Val Asn Lys Asn Ile Gly Leu 
145                 150                 155                 160 
Ser Ile Ile Ile Pro Thr Phe Asn Arg Ser Arg Ile Leu Asp Ile Thr 
                165                 170                 175     
Leu Ala Cys Leu Val Asn Gln Lys Thr Asn Tyr Pro Phe Glu Val Val 
            180                 185                 190         
Val Ala Asp Asp Gly Ser Lys Glu Asn Leu Leu Thr Ile Val Gln Lys 
        195                 200                 205             
Tyr Glu Gln Lys Leu Asp Ile Lys Tyr Val Arg Gln Lys Asp Tyr Gly 
    210                 215                 220                 
Tyr Gln Leu Cys Ala Val Arg Asn Leu Gly Leu Arg Thr Ala Lys Tyr 
225                 230                 235                 240 
Asp Phe Val Ser Ile Leu Asp Cys Asp Met Ala Pro Gln Gln Leu Trp 
                245                 250                 255     
Val His Ser Tyr Leu Thr Glu Leu Leu Glu Asp Asn Asp Ile Val Leu 
            260                 265                 270         
Ile Gly Pro Arg Lys Tyr Val Asp Thr His Asn Ile Thr Ala Glu Gln 
        275                 280                 285             
Phe Leu Asn Asp Pro Tyr Leu Ile Glu Ser Leu Pro Glu Thr Ala Thr 
    290                 295                 300                 
Asn Asn Asn Pro Ser Ile Thr Ser Lys Gly Asn Ile Ser Leu Asp Trp 
305                 310                 315                 320 
Arg Leu Glu His Phe Lys Lys Thr Asp Asn Leu Arg Leu Cys Asp Ser 
                325                 330                 335     
Pro Phe Arg Tyr Phe Ser Cys Gly Asn Val Ala Phe Ser Lys Glu Trp 
            340                 345                 350         
Leu Asn Lys Val Gly Trp Phe Asp Glu Glu Phe Asn His Trp Gly Gly 
        355                 360                 365             
Glu Asp Val Glu Phe Gly Tyr Arg Leu Phe Ala Lys Gly Cys Phe Phe 
    370                 375                 380                 
Arg Val Ile Asp Gly Gly Met Ala Tyr His Gln Glu Pro Pro Gly Lys 
385                 390                 395                 400 
Glu Asn Glu Thr Asp Arg Glu Ala Gly Lys Ser Ile Thr Leu Lys Ile 
                405                 410                 415     
Val Lys Glu Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile Glu 
            420                 425                 430         
Asp Ser His Ile Asn Arg Val Pro Leu Val Ser Ile Tyr Ile Pro Ala 
        435                 440                 445             
Tyr Asn Cys Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu Asn 
    450                 455                 460                 
Gln Thr Val Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser Thr 
465                 470                 475                 480 
Asp Asn Thr Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro Arg 
                485                 490                 495     
Val Arg Ile Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser Asn 
            500                 505                 510         
Ala Ala Val Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp Ser 
        515                 520                 525             
Asp Asp Tyr Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu Phe 
    530                 535                 540                 
Leu Lys Asp Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn Val 
545                 550                 555                 560 
Asn Pro Asp Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Glu Phe 
                565                 570                 575     
Ser Arg Glu Lys Leu Thr Thr Ala Met Ile Ala His His Phe Arg Met 
            580                 585                 590         
Phe Thr Ile Arg Ala Trp His Leu Thr Asp Gly Phe Asn Glu Lys Ile 
        595                 600                 605             
Glu Asn Ala Val Asp Tyr Asp Met Phe Leu Lys Leu Ser Glu Val Gly 
    610                 615                 620                 
Lys Phe Lys His Leu Asn Lys Ile Cys Tyr Asn Arg Val Leu His Gly 
625                 630                 635                 640 
Asp Asn Thr Ser Ile Lys Lys Leu Gly Ile Gln Lys Lys Asn His Phe 
                645                 650                 655     
Val Val Val Asn Gln Ser Leu Asn Arg Gln Gly Ile Thr Tyr Tyr Asn 
            660                 665                 670         
Tyr Asp Glu Phe Asp Asp Leu Asp Glu Ser Arg Lys Tyr Ile Phe Asn 
        675                 680                 685             
Lys Thr Ala Glu Tyr Gln Glu Glu Ile Asp Ile Leu Lys Asp Ile Lys 
    690                 695                 700                 
Ile Ile Gln Asn Lys Asp Ala Lys Ile Ala Val Ser Ile Phe Tyr Pro 
705                 710                 715                 720 
Asn Thr Leu Asn Gly Leu Val Lys Lys Leu Asn Asn Ile Ile Glu Tyr 
                725                 730                 735     
Asn Lys Asn Ile Phe Val Ile Val Leu His Val Asp Lys Asn His Leu 
            740                 745                 750         
Thr Pro Asp Ile Lys Lys Glu Ile Leu Ala Phe Tyr His Lys His Gln 
        755                 760                 765             
Val Asn Ile Leu Leu Asn Asn Asp Ile Ser Tyr Tyr Thr Ser Asn Arg 
    770                 775                 780                 
Leu Ile Lys Thr Glu Ala His Leu Ser Asn Ile Asn Lys Leu Ser Gln 
785                 790                 795                 800 
Leu Asn Leu Asn Cys Glu Tyr Ile Ile Phe Asp Asn His Asp Ser Leu 
                805                 810                 815     
Phe Val Lys Asn Asp Ser Tyr Ala Tyr Met Lys Lys Tyr Asp Val Gly 
            820                 825                 830         
Met Asn Phe Ser Ala Leu Thr His Asp Trp Ile Glu Lys Ile Asn Ala 
        835                 840                 845             
His Pro Pro Phe Lys Lys Leu Ile Lys Thr Tyr Phe Asn Asp Asn Asp 
    850                 855                 860                 
Leu Lys Ser Met Asn Val Lys Gly Ala Ser Gln Gly Met Phe Met Thr 
865                 870                 875                 880 
Tyr Ala Leu Ala His Glu Leu Leu Thr Ile Ile Lys Glu Val Ile Thr 
                885                 890                 895     
Ser Cys Gln Ser Ile Asp Ser Val Pro Glu Tyr Asn Thr Glu Asp Ile 
            900                 905                 910         
Trp Phe Gln Phe Ala Leu Leu Ile Leu Glu Lys Lys Thr Gly His Val 
        915                 920                 925             
Phe Asn Lys Thr Ser Thr Leu Thr Tyr Met Pro Trp Glu Arg Lys Leu 
    930                 935                 940                 
Gln Trp Thr Asn Glu Gln Ile Glu Ser Ala Lys Arg Gly Glu Asn Ile 
945                 950                 955                 960 
Pro Val Asn Lys Phe Ile Ile Asn Ser Ile Thr Leu 
                965                 970         

<210> 21
<211> 1023
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of a polypeptide having chondroitin synthase
      activity (HCOS.Sc)

<400> 21
Met Asn Thr Leu Ser Gln Ala Ile Lys Ala Tyr Asn Ser Asn Asp Tyr 
1               5                   10                  15      
Gln Leu Ala Leu Lys Leu Phe Glu Lys Ser Ala Glu Ile Tyr Gly Arg 
            20                  25                  30          
Lys Ile Val Glu Phe Gln Ile Thr Lys Cys Lys Glu Lys Leu Ser Ala 
        35                  40                  45              
His Pro Ser Val Asn Ser Ala His Leu Ser Val Asn Lys Glu Glu Lys 
    50                  55                  60                  
Val Asn Val Cys Asp Ser Pro Leu Asp Ile Ala Thr Gln Leu Leu Leu 
65                  70                  75                  80  
Ser Asn Val Lys Lys Leu Val Leu Ser Asp Ser Glu Lys Asn Thr Leu 
                85                  90                  95      
Lys Asn Lys Trp Lys Leu Leu Thr Glu Lys Lys Ser Glu Asn Ala Glu 
            100                 105                 110         
Val Arg Ala Val Ala Leu Val Pro Lys Asp Phe Pro Lys Asp Leu Val 
        115                 120                 125             
Leu Ala Pro Leu Pro Asp His Val Asn Asp Phe Thr Trp Tyr Lys Asn 
    130                 135                 140                 
Arg Lys Lys Ser Leu Gly Ile Lys Pro Val Asn Lys Asn Ile Gly Leu 
145                 150                 155                 160 
Ser Ile Ile Ile Pro Thr Phe Asn Arg Ser Arg Ile Leu Asp Ile Thr 
                165                 170                 175     
Leu Ala Cys Leu Val Asn Gln Lys Thr Asn Tyr Pro Phe Glu Val Val 
            180                 185                 190         
Val Ala Asp Asp Gly Ser Lys Glu Asn Leu Leu Thr Ile Val Gln Lys 
        195                 200                 205             
Tyr Glu Gln Lys Leu Asp Ile Lys Tyr Val Arg Gln Lys Asp Tyr Gly 
    210                 215                 220                 
Tyr Gln Leu Cys Ala Val Arg Asn Leu Gly Leu Arg Thr Ala Lys Tyr 
225                 230                 235                 240 
Asp Phe Val Ser Ile Leu Asp Cys Asp Met Ala Pro Gln Gln Leu Trp 
                245                 250                 255     
Val His Ser Tyr Leu Thr Glu Leu Leu Glu Asp Asn Asp Ile Val Leu 
            260                 265                 270         
Ile Gly Pro Arg Lys Tyr Val Asp Thr His Asn Ile Thr Ala Glu Gln 
        275                 280                 285             
Phe Leu Asn Asp Pro Tyr Leu Ile Glu Ser Leu Pro Glu Thr Ala Thr 
    290                 295                 300                 
Asn Asn Asn Pro Ser Ile Thr Ser Lys Gly Asn Ile Ser Leu Asp Trp 
305                 310                 315                 320 
Arg Leu Glu His Phe Lys Lys Thr Asp Asn Leu Arg Leu Cys Asp Ser 
                325                 330                 335     
Pro Phe Arg Tyr Phe Ser Cys Gly Asn Val Ala Phe Ser Lys Glu Trp 
            340                 345                 350         
Leu Asn Lys Val Gly Trp Phe Asp Glu Glu Phe Asn His Trp Gly Gly 
        355                 360                 365             
Glu Asp Val Glu Phe Gly Tyr Arg Leu Phe Ala Lys Gly Cys Phe Phe 
    370                 375                 380                 
Arg Val Ile Asp Gly Gly Met Ala Tyr His Gln Glu Pro Pro Gly Lys 
385                 390                 395                 400 
Glu Asn Glu Thr Asp Arg Glu Ala Gly Lys Ser Ile Thr Leu Lys Ile 
                405                 410                 415     
Val Lys Glu Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile Glu 
            420                 425                 430         
Asp Ser His Ile Asn Arg Val Pro Leu Val Ser Ile Tyr Ile Pro Ala 
        435                 440                 445             
Tyr Asn Cys Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu Asn 
    450                 455                 460                 
Gln Thr Val Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser Thr 
465                 470                 475                 480 
Asp Asn Thr Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro Arg 
                485                 490                 495     
Val Arg Ile Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser Asn 
            500                 505                 510         
Ala Ala Val Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp Ser 
        515                 520                 525             
Asp Asp Tyr Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu Phe 
    530                 535                 540                 
Leu Lys Asp Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn Val 
545                 550                 555                 560 
Asn Pro Asp Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Glu Phe 
                565                 570                 575     
Ser Arg Glu Lys Leu Thr Thr Ala Met Ile Ala His His Phe Arg Met 
            580                 585                 590         
Phe Thr Ile Arg Ala Trp His Leu Thr Asp Gly Phe Asn Glu Lys Ile 
        595                 600                 605             
Glu Asn Ala Val Asp Tyr Asp Met Phe Leu Lys Leu Ser Glu Val Gly 
    610                 615                 620                 
Lys Phe Lys His Leu Asn Lys Ile Cys Tyr Asn Arg Val Leu His Gly 
625                 630                 635                 640 
Asp Asn Thr Ser Ile Lys Lys Leu Gly Ile Gln Lys Lys Asn His Phe 
                645                 650                 655     
Val Val Val Asn Gln Ser Leu Asn Arg Gln Gly Ile Thr Tyr Tyr Asn 
            660                 665                 670         
Tyr Asp Glu Phe Asp Asp Leu Asp Glu Ser Arg Lys Tyr Ile Phe Asn 
        675                 680                 685             
Lys Thr Ala Glu Tyr Gln Glu Glu Ile Asp Ile Leu Lys Asp Ile Phe 
    690                 695                 700                 
Ile Gln Met Leu Phe Ser Trp Phe Ser Ile Ala Asn Phe Val Leu Thr 
705                 710                 715                 720 
Phe Tyr Tyr Leu Ala Gly Ser Met Asn Leu Val Ile Lys His Gly Glu 
                725                 730                 735     
Ala Leu Phe Ile Phe Phe Lys Tyr Leu Ile Phe Cys Asp Leu Ala Ser 
            740                 745                 750         
Leu Phe Ile Ile Ser Met Gly Asn Arg Pro Gln Gly Ala Lys His Leu 
        755                 760                 765             
Phe Ile Thr Ser Met Val Ile Leu Ser Ile Cys Ala Thr Tyr Ser Leu 
    770                 775                 780                 
Ile Cys Gly Phe Val Phe Ala Phe Lys Ser Leu Ala Ser Gly Thr Glu 
785                 790                 795                 800 
Ser His Lys Ile Phe Val Asp Ile Val Ile Ser Leu Leu Ser Thr Tyr 
                805                 810                 815     
Gly Leu Tyr Phe Phe Ser Ser Leu Met Tyr Leu Asp Pro Trp His Met 
            820                 825                 830         
Phe Thr Ser Ser Ile Gln Tyr Phe Leu Thr Leu Pro Ala Phe Thr Cys 
        835                 840                 845             
Thr Leu Gln Ile Phe Ala Phe Cys Asn Thr His Asp Val Ser Trp Gly 
    850                 855                 860                 
Thr Lys Gly Ser Thr Gln Glu Ser Lys Gln Leu Ser Lys Ala Ile Val 
865                 870                 875                 880 
Val Gln Gly Pro Asp Gly Lys Gln Ile Val Glu Thr Asp Trp Pro Gln 
                885                 890                 895     
Glu Val Asp Lys Lys Phe Leu Glu Ile Lys Ser Arg Leu Lys Glu Pro 
            900                 905                 910         
Glu Phe Glu Glu Ser Ser Gly Asn Glu Lys Gln Ser Lys Asn Asp Tyr 
        915                 920                 925             
Tyr Arg Asp Ile Arg Thr Arg Ile Val Met Ile Trp Met Leu Ser Asn 
    930                 935                 940                 
Leu Ile Leu Ile Met Ser Ile Ile Gln Val Phe Thr Pro Gln Asp Thr 
945                 950                 955                 960 
Asp Asn Gly Tyr Leu Ile Phe Ile Leu Trp Ser Val Ala Ala Leu Ala 
                965                 970                 975     
Ala Phe Arg Val Val Gly Ser Met Ala Phe Leu Phe Met Lys Tyr Leu 
            980                 985                 990         
Arg Ile Ile Val Ser Tyr Arg Asn Lys Val Glu Gly Ser Gly Ser Trp 
        995                 1000                1005            
Glu Val Ser Lys Leu Asp Leu Pro Asn Val Phe His Lys Lys Gly 
    1010                1015                1020            

<210> 22
<211> 1023
<212> PRT
<213> other sequences


<220> 
<223> an amino acid sequence of a polypeptide having chondroitin
      synthase activity (HHASA.Sc)

<400> 22
Met Asn Thr Leu Ser Gln Ala Ile Lys Ala Tyr Asn Ser Asn Asp Tyr 
1               5                   10                  15      
Gln Leu Ala Leu Lys Leu Phe Glu Lys Ser Ala Glu Ile Tyr Gly Arg 
            20                  25                  30          
Lys Ile Val Glu Phe Gln Ile Thr Lys Cys Lys Glu Lys Leu Ser Ala 
        35                  40                  45              
His Pro Ser Val Asn Ser Ala His Leu Ser Val Asn Lys Glu Glu Lys 
    50                  55                  60                  
Val Asn Val Cys Asp Ser Pro Leu Asp Ile Ala Thr Gln Leu Leu Leu 
65                  70                  75                  80  
Ser Asn Val Lys Lys Leu Val Leu Ser Asp Ser Glu Lys Asn Thr Leu 
                85                  90                  95      
Lys Asn Lys Trp Lys Leu Leu Thr Glu Lys Lys Ser Glu Asn Ala Glu 
            100                 105                 110         
Val Arg Ala Val Ala Leu Val Pro Lys Asp Phe Pro Lys Asp Leu Val 
        115                 120                 125             
Leu Ala Pro Leu Pro Asp His Val Asn Asp Phe Thr Trp Tyr Lys Lys 
    130                 135                 140                 
Arg Lys Lys Arg Leu Gly Ile Lys Pro Glu His Gln His Val Gly Leu 
145                 150                 155                 160 
Ser Ile Ile Val Thr Thr Phe Asn Arg Pro Ala Ile Leu Ser Ile Thr 
                165                 170                 175     
Leu Ala Cys Leu Val Asn Gln Lys Thr His Tyr Pro Phe Glu Val Ile 
            180                 185                 190         
Val Thr Asp Asp Gly Ser Gln Glu Asp Leu Ser Pro Ile Ile Arg Gln 
        195                 200                 205             
Tyr Glu Asn Lys Leu Asp Ile Arg Tyr Val Arg Gln Lys Asp Asn Gly 
    210                 215                 220                 
Phe Gln Ala Ser Ala Ala Arg Asn Met Gly Leu Arg Leu Ala Lys Tyr 
225                 230                 235                 240 
Asp Phe Ile Gly Leu Leu Asp Cys Asp Met Ala Pro Asn Pro Leu Trp 
                245                 250                 255     
Val His Ser Tyr Val Ala Glu Leu Leu Glu Asp Asp Asp Leu Thr Ile 
            260                 265                 270         
Ile Gly Pro Arg Lys Tyr Ile Asp Thr Gln His Ile Asp Pro Lys Asp 
        275                 280                 285             
Phe Leu Asn Asn Ala Ser Leu Leu Glu Ser Leu Pro Glu Val Lys Thr 
    290                 295                 300                 
Asn Asn Ser Val Ala Ala Lys Gly Glu Gly Thr Val Ser Leu Asp Trp 
305                 310                 315                 320 
Arg Leu Glu Gln Phe Glu Lys Thr Glu Asn Leu Arg Leu Ser Asp Ser 
                325                 330                 335     
Pro Phe Arg Phe Phe Ala Ala Gly Asn Val Ala Phe Ala Lys Lys Trp 
            340                 345                 350         
Leu Asn Lys Ser Gly Phe Phe Asp Glu Glu Phe Asn His Trp Gly Gly 
        355                 360                 365             
Glu Asp Val Glu Phe Gly Tyr Arg Leu Phe Arg Tyr Gly Ser Phe Phe 
    370                 375                 380                 
Lys Thr Ile Asp Gly Ile Met Ala Tyr His Gln Glu Pro Pro Gly Lys 
385                 390                 395                 400 
Glu Asn Glu Thr Asp Arg Glu Ala Gly Lys Asn Ile Thr Leu Asp Ile 
                405                 410                 415     
Met Arg Glu Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile Glu 
            420                 425                 430         
Asp Ser His Ile Asn Arg Val Pro Leu Val Ser Ile Tyr Ile Pro Ala 
        435                 440                 445             
Tyr Asn Cys Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu Asn 
    450                 455                 460                 
Gln Thr Val Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser Thr 
465                 470                 475                 480 
Asp Asn Thr Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro Arg 
                485                 490                 495     
Val Arg Ile Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser Asn 
            500                 505                 510         
Ala Ala Val Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp Ser 
        515                 520                 525             
Asp Asp Tyr Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu Phe 
    530                 535                 540                 
Leu Lys Asp Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn Val 
545                 550                 555                 560 
Asn Pro Asp Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Glu Phe 
                565                 570                 575     
Ser Arg Glu Lys Leu Thr Thr Ala Met Ile Ala His His Phe Arg Met 
            580                 585                 590         
Phe Thr Ile Arg Ala Trp His Leu Thr Asp Gly Phe Asn Glu Lys Ile 
        595                 600                 605             
Glu Asn Ala Val Asp Tyr Asp Met Phe Leu Lys Leu Ser Glu Val Gly 
    610                 615                 620                 
Lys Phe Lys His Leu Asn Lys Ile Cys Tyr Asn Arg Val Leu His Gly 
625                 630                 635                 640 
Asp Asn Thr Ser Ile Lys Lys Leu Gly Ile Gln Lys Lys Asn His Phe 
                645                 650                 655     
Val Val Val Asn Gln Ser Leu Asn Arg Gln Gly Ile Thr Tyr Tyr Asn 
            660                 665                 670         
Tyr Asp Glu Phe Asp Asp Leu Asp Glu Ser Arg Lys Tyr Ile Phe Asn 
        675                 680                 685             
Lys Thr Ala Glu Tyr Gln Glu Glu Ile Asp Ile Leu Lys Asp Ile Phe 
    690                 695                 700                 
Ile Gln Met Leu Phe Ser Trp Phe Ser Ile Ala Asn Phe Val Leu Thr 
705                 710                 715                 720 
Phe Tyr Tyr Leu Ala Gly Ser Met Asn Leu Val Ile Lys His Gly Glu 
                725                 730                 735     
Ala Leu Phe Ile Phe Phe Lys Tyr Leu Ile Phe Cys Asp Leu Ala Ser 
            740                 745                 750         
Leu Phe Ile Ile Ser Met Gly Asn Arg Pro Gln Gly Ala Lys His Leu 
        755                 760                 765             
Phe Ile Thr Ser Met Val Ile Leu Ser Ile Cys Ala Thr Tyr Ser Leu 
    770                 775                 780                 
Ile Cys Gly Phe Val Phe Ala Phe Lys Ser Leu Ala Ser Gly Thr Glu 
785                 790                 795                 800 
Ser His Lys Ile Phe Val Asp Ile Val Ile Ser Leu Leu Ser Thr Tyr 
                805                 810                 815     
Gly Leu Tyr Phe Phe Ser Ser Leu Met Tyr Leu Asp Pro Trp His Met 
            820                 825                 830         
Phe Thr Ser Ser Ile Gln Tyr Phe Leu Thr Leu Pro Ala Phe Thr Cys 
        835                 840                 845             
Thr Leu Gln Ile Phe Ala Phe Cys Asn Thr His Asp Val Ser Trp Gly 
    850                 855                 860                 
Thr Lys Gly Ser Thr Gln Glu Ser Lys Gln Leu Ser Lys Ala Ile Val 
865                 870                 875                 880 
Val Gln Gly Pro Asp Gly Lys Gln Ile Val Glu Thr Asp Trp Pro Gln 
                885                 890                 895     
Glu Val Asp Lys Lys Phe Leu Glu Ile Lys Ser Arg Leu Lys Glu Pro 
            900                 905                 910         
Glu Phe Glu Glu Ser Ser Gly Asn Glu Lys Gln Ser Lys Asn Asp Tyr 
        915                 920                 925             
Tyr Arg Asp Ile Arg Thr Arg Ile Val Met Ile Trp Met Leu Ser Asn 
    930                 935                 940                 
Leu Ile Leu Ile Met Ser Ile Ile Gln Val Phe Thr Pro Gln Asp Thr 
945                 950                 955                 960 
Asp Asn Gly Tyr Leu Ile Phe Ile Leu Trp Ser Val Ala Ala Leu Ala 
                965                 970                 975     
Ala Phe Arg Val Val Gly Ser Met Ala Phe Leu Phe Met Lys Tyr Leu 
            980                 985                 990         
Arg Ile Ile Val Ser Tyr Arg Asn Lys Val Glu Gly Ser Gly Ser Trp 
        995                 1000                1005            
Glu Val Ser Lys Leu Asp Leu Pro Asn Val Phe His Lys Lys Gly 
    1010                1015                1020            

<210> 23
<211> 572
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of a polypeptide having chondroitin synthase
      activity (HCOS1-Vir)

<400> 23
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Gly Trp Asn Asp Val Arg Leu Ala Val Ile Ile Ala 
                85                  90                  95      
Gly Tyr Arg Glu Asp Pro Tyr Met Phe Gln Lys Cys Leu Glu Ser Val 
            100                 105                 110         
Arg Asp Ser Asp Tyr Gly Asn Val Ala Arg Leu Ile Cys Val Ile Asp 
        115                 120                 125             
Gly Asp Glu Asp Asp Asp Met Arg Met Ala Ala Val Tyr Lys Ala Ile 
    130                 135                 140                 
Tyr Asn Asp Asn Ile Lys Lys Pro Glu Phe Val Leu Cys Glu Ser Asp 
145                 150                 155                 160 
Asp Lys Glu Gly Glu Arg Ile Asp Ser Asp Phe Ser Arg Asp Ile Cys 
                165                 170                 175     
Val Leu Gln Pro His Arg Gly Lys Arg Glu Cys Leu Tyr Thr Gly Phe 
            180                 185                 190         
Gln Leu Ala Lys Met Asp Pro Ser Val Asn Ala Val Val Leu Ile Asp 
        195                 200                 205             
Ser Asp Thr Val Leu Glu Lys Asp Ala Ile Leu Glu Val Val Tyr Pro 
    210                 215                 220                 
Leu Ala Cys Asp Pro Glu Ile Gln Ala Val Ala Gly Glu Cys Lys Ile 
225                 230                 235                 240 
Trp Asn Thr Asp Thr Leu Leu Ser Leu Leu Val Ala Trp Arg Tyr Tyr 
                245                 250                 255     
Ser Ala Phe Cys Val Glu Arg Ser Ala Gln Ser Phe Phe Arg Thr Val 
            260                 265                 270         
Gln Cys Val Gly Gly Pro Leu Gly Ala Tyr Lys Ile Asp Ile Ile Lys 
        275                 280                 285             
Glu Ile Lys Asp Pro Trp Ile Ser Gln Arg Phe Leu Gly Gln Lys Cys 
    290                 295                 300                 
Thr Tyr Gly Asp Asp Arg Arg Leu Thr Asn Glu Ile Leu Met Arg Gly 
305                 310                 315                 320 
Lys Lys Val Val Phe Thr Pro Phe Ala Val Gly Trp Gly Trp Phe Asp 
                325                 330                 335     
Glu Glu Phe Thr His Trp Gly Gly Arg Tyr Ile Val Gln Gln Thr Arg 
            340                 345                 350         
Trp Ser Lys Ser Trp Cys Arg Glu Ile Trp Tyr Thr Leu Phe Ala Ala 
        355                 360                 365             
Trp Lys His Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr 
    370                 375                 380                 
Gln Ile Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala 
385                 390                 395                 400 
Val Glu Ala Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr 
                405                 410                 415     
Thr Val Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp 
            420                 425                 430         
Ile Arg Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys 
        435                 440                 445             
Met Ile Pro Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly 
    450                 455                 460                 
Trp Gly Thr Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val 
465                 470                 475                 480 
Ala Leu Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala 
                485                 490                 495     
Val Val Gly Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp 
            500                 505                 510         
Trp Asn Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr 
        515                 520                 525             
Ile Val Phe Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile 
    530                 535                 540                 
Thr Thr Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg 
545                 550                 555                 560 
Val Leu Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
                565                 570         

<210> 24
<211> 571
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS2-Vir)

<400> 24
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Gly Trp Asn Asp Val Arg Leu Ala Val Ile Ile Ala 
                85                  90                  95      
Gly Tyr Arg Glu Asp Pro Tyr Met Phe Gln Lys Cys Leu Glu Ser Val 
            100                 105                 110         
Arg Asp Ser Asp Tyr Gly Asn Val Ala Arg Leu Ile Cys Val Ile Asp 
        115                 120                 125             
Gly Asp Glu Asp Asp Asp Met Arg Met Ala Ala Val Tyr Lys Ala Ile 
    130                 135                 140                 
Tyr Asn Asp Asn Ile Lys Lys Pro Glu Phe Val Leu Cys Glu Ser Asp 
145                 150                 155                 160 
Asp Lys Glu Gly Glu Arg Ile Asp Ser Asp Phe Ser Arg Asp Ile Cys 
                165                 170                 175     
Val Leu Gln Pro His Arg Gly Lys Arg Glu Cys Leu Tyr Thr Gly Phe 
            180                 185                 190         
Gln Leu Ala Lys Met Asp Pro Ser Val Asn Ala Val Val Leu Ile Asp 
        195                 200                 205             
Ser Asp Thr Val Leu Glu Lys Asp Ala Ile Leu Glu Val Val Tyr Pro 
    210                 215                 220                 
Leu Ala Cys Asp Pro Glu Ile Gln Ala Val Ala Gly Glu Cys Lys Ile 
225                 230                 235                 240 
Trp Asn Thr Asp Thr Leu Leu Ser Leu Leu Val Ala Trp Arg Tyr Tyr 
                245                 250                 255     
Ser Ala Phe Cys Val Glu Arg Ser Ala Gln Ser Phe Phe Arg Thr Val 
            260                 265                 270         
Gln Cys Val Gly Gly Pro Leu Gly Ala Tyr Lys Ile Asp Ile Ile Lys 
        275                 280                 285             
Glu Ile Lys Asp Pro Trp Ile Ser Gln Arg Phe Leu Gly Gln Lys Cys 
    290                 295                 300                 
Thr Tyr Gly Asp Asp Arg Arg Leu Thr Asn Glu Ile Leu Met Arg Gly 
305                 310                 315                 320 
Lys Lys Val Val Phe Thr Pro Phe Ala Val Gly Trp Leu His Gly Glu 
                325                 330                 335     
Asn Thr Ser Ile Lys Lys Leu Arg Tyr Ile Val Gln Gln Thr Arg Trp 
            340                 345                 350         
Ser Lys Ser Trp Cys Arg Glu Ile Trp Tyr Thr Leu Phe Ala Ala Trp 
        355                 360                 365             
Lys His Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr Gln 
    370                 375                 380                 
Ile Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala Val 
385                 390                 395                 400 
Glu Ala Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr Thr 
                405                 410                 415     
Val Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp Ile 
            420                 425                 430         
Arg Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys Met 
        435                 440                 445             
Ile Pro Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly Trp 
    450                 455                 460                 
Gly Thr Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val Ala 
465                 470                 475                 480 
Leu Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala Val 
                485                 490                 495     
Val Gly Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp Trp 
            500                 505                 510         
Asn Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr Ile 
        515                 520                 525             
Val Phe Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile Thr 
    530                 535                 540                 
Thr Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg Val 
545                 550                 555                 560 
Leu Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
                565                 570     

<210> 25
<211> 572
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS3-Vir)

<400> 25
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Gly Trp Asn Asp Val Arg Leu Ala Val Ile Ile Ala 
                85                  90                  95      
Gly Tyr Arg Glu Asp Pro Tyr Met Phe Gln Lys Cys Leu Glu Ser Val 
            100                 105                 110         
Arg Asp Ser Asp Tyr Gly Asn Val Ala Arg Leu Ile Cys Val Ile Asp 
        115                 120                 125             
Gly Asp Glu Asp Asp Asp Met Arg Met Ala Ala Val Tyr Lys Ala Ile 
    130                 135                 140                 
Tyr Asn Asp Asn Ile Lys Lys Pro Glu Phe Val Leu Cys Glu Ser Asp 
145                 150                 155                 160 
Asp Lys Glu Gly Glu Arg Ile Asp Ser Asp Phe Ser Arg Asp Ile Cys 
                165                 170                 175     
Val Leu Gln Pro His Arg Gly Lys Arg Glu Cys Leu Tyr Thr Gly Phe 
            180                 185                 190         
Gln Leu Ala Lys Met Asp Pro Ser Val Asn Ala Val Val Leu Ile Asp 
        195                 200                 205             
Ser Asp Thr Val Leu Glu Lys Asp Ala Ile Leu Glu Val Val Tyr Pro 
    210                 215                 220                 
Leu Ala Cys Asp Pro Glu Ile Gln Ala Val Ala Gly Glu Cys Lys Ile 
225                 230                 235                 240 
Trp Asn Thr Asp Thr Leu Leu Ser Leu Leu Val Ala Trp Arg Tyr Tyr 
                245                 250                 255     
Ser Ala Phe Cys Val Glu Arg Ser Ala Gln Ser Phe Phe Arg Thr Val 
            260                 265                 270         
Gln Cys Val Gly Gly Pro Leu Gly Ala Tyr Lys Ile Asp Ile Ile Lys 
        275                 280                 285             
Glu Ile Lys Asp Pro Trp Ile Ser Gln Arg Phe Leu Gly Gln Lys Cys 
    290                 295                 300                 
Thr Tyr Gly Asp Asp Arg Arg Leu Thr Asn Glu Ile Leu Met Arg Gly 
305                 310                 315                 320 
Lys Lys Val Val Phe Thr Pro Phe Ala Val Gly Trp His Met Ala Trp 
                325                 330                 335     
Ser Asp Lys Asp Asp Ala Ile Asp Arg Tyr Ile Val Gln Gln Thr Arg 
            340                 345                 350         
Trp Ser Lys Ser Trp Cys Arg Glu Ile Trp Tyr Thr Leu Phe Ala Ala 
        355                 360                 365             
Trp Lys His Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr 
    370                 375                 380                 
Gln Ile Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala 
385                 390                 395                 400 
Val Glu Ala Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr 
                405                 410                 415     
Thr Val Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp 
            420                 425                 430         
Ile Arg Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys 
        435                 440                 445             
Met Ile Pro Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly 
    450                 455                 460                 
Trp Gly Thr Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val 
465                 470                 475                 480 
Ala Leu Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala 
                485                 490                 495     
Val Val Gly Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp 
            500                 505                 510         
Trp Asn Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr 
        515                 520                 525             
Ile Val Phe Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile 
    530                 535                 540                 
Thr Thr Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg 
545                 550                 555                 560 
Val Leu Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
                565                 570         

<210> 26
<211> 570
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS4-Vir)

<400> 26
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Gly Trp Asn Asp Val Arg Leu Ala Val Ile Ile Ala 
                85                  90                  95      
Gly Tyr Arg Glu Asp Pro Tyr Met Phe Gln Lys Cys Leu Glu Ser Val 
            100                 105                 110         
Arg Asp Ser Asp Tyr Gly Asn Val Ala Arg Leu Ile Cys Val Ile Asp 
        115                 120                 125             
Gly Asp Glu Asp Asp Asp Met Arg Met Ala Ala Val Tyr Lys Ala Ile 
    130                 135                 140                 
Tyr Asn Asp Asn Ile Lys Lys Pro Glu Phe Val Leu Cys Glu Ser Asp 
145                 150                 155                 160 
Asp Lys Glu Gly Glu Arg Ile Asp Ser Asp Phe Ser Arg Asp Ile Cys 
                165                 170                 175     
Val Leu Gln Pro His Arg Gly Lys Arg Glu Cys Leu Tyr Thr Gly Phe 
            180                 185                 190         
Gln Leu Ala Lys Met Asp Pro Ser Val Asn Ala Val Val Leu Ile Asp 
        195                 200                 205             
Ser Asp Thr Val Leu Glu Lys Asp Ala Ile Leu Glu Val Val Tyr Pro 
    210                 215                 220                 
Leu Ala Cys Asp Pro Glu Ile Gln Ala Val Ala Gly Glu Cys Lys Ile 
225                 230                 235                 240 
Trp Asn Thr Asp Thr Leu Leu Ser Leu Leu Val Ala Trp Arg Tyr Tyr 
                245                 250                 255     
Ser Ala Phe Cys Val Glu Arg Ser Ala Gln Ser Phe Phe Arg Thr Val 
            260                 265                 270         
Gln Cys Val Gly Gly Pro Leu Gly Ala Tyr Lys Ile Asp Ile Ile Lys 
        275                 280                 285             
Glu Ile Lys Asp Pro Trp Ile Ser Gln Arg Phe Leu Gly Gln Lys Cys 
    290                 295                 300                 
Thr Tyr Gly Asp Asp Arg Arg Leu Thr Asn Glu Ile Leu Met Arg Gly 
305                 310                 315                 320 
Lys Lys Val Val Phe Thr Pro Phe Ala Val Gly Trp Phe Asp Glu Glu 
                325                 330                 335     
Phe Thr His Trp Gly Gly Arg Tyr Ile Val Gln Gln Thr Arg Trp Ser 
            340                 345                 350         
Lys Ser Trp Cys Arg Glu Ile Trp Tyr Thr Leu Phe Ala Ala Trp Lys 
        355                 360                 365             
His Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr Gln Ile 
    370                 375                 380                 
Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala Val Glu 
385                 390                 395                 400 
Ala Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr Thr Val 
                405                 410                 415     
Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp Ile Arg 
            420                 425                 430         
Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys Met Ile 
        435                 440                 445             
Pro Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly Trp Gly 
    450                 455                 460                 
Thr Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val Ala Leu 
465                 470                 475                 480 
Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala Val Val 
                485                 490                 495     
Gly Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp Trp Asn 
            500                 505                 510         
Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr Ile Val 
        515                 520                 525             
Phe Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile Thr Thr 
    530                 535                 540                 
Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg Val Leu 
545                 550                 555                 560 
Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
                565                 570 

<210> 27
<211> 692
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of a polypeptide having chondroitin synthase
      activity (HCOS5-Vir)

<400> 27
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Ser Ile His His Pro Ile Ser Lys Thr Thr His Pro 
                85                  90                  95      
Asp Thr Glu Asn Ala Gly Asp Ser Thr Leu Leu Cys Pro Pro Met Asp 
            100                 105                 110         
Gly Met Asp Asp Ile Leu Val Val Met Lys Thr Gly Val Thr Glu Ala 
        115                 120                 125             
Lys Glu Lys Val Pro Val His Phe Gln Thr Thr Leu Arg Cys Val Pro 
    130                 135                 140                 
His Tyr Val Ile Tyr Ser Asp Phe Glu Glu Glu Ile Glu Gly Val Lys 
145                 150                 155                 160 
Ile Tyr Asp Val Leu Gln Gly Met Asp Pro Asp Val Met Thr Gln Val 
                165                 170                 175     
Pro Asp Phe Asp Leu Tyr Asn Arg Ile Lys Lys Leu Gly Arg Gln Gly 
            180                 185                 190         
Leu Ala Glu Asn Asp Phe Ala Asp Glu Ala Asn Ser Ala Val Gly Lys 
        195                 200                 205             
Pro Asn Asn Pro Gly Trp Lys Leu Asp Lys Trp Lys Phe Leu Pro Met 
    210                 215                 220                 
Ile Ile Glu Ala Leu Arg Tyr Lys Pro Lys Ala Lys Trp Tyr Val Phe 
225                 230                 235                 240 
Met Glu Ala Asp Thr Tyr Ile Ser Trp Pro Thr Leu Leu Ala Trp Leu 
                245                 250                 255     
Lys His Phe Asn His Lys Lys Pro Trp Tyr Leu Gly Thr Glu Thr Gln 
            260                 265                 270         
Ile Ala Asp Val Ile Phe Ala His Gly Gly Ser Gly Phe Met Ile Ser 
        275                 280                 285             
His Ala Ala Leu Lys Leu Ala Ala Glu Glu Tyr Thr Ala Arg Arg Thr 
    290                 295                 300                 
Glu Leu His His Tyr Thr Asp Gly His Trp Ala Gly Asp Cys Val Leu 
305                 310                 315                 320 
Gly Lys Val Leu Ala Asp Ala Gly Val Asn Leu His Phe Ser Trp Pro 
                325                 330                 335     
Ile Leu Gln Asn Ser Asn Leu Gly Glu Leu Asp Glu Phe Asn Val Asp 
            340                 345                 350         
Leu Tyr Arg Gln Pro Trp Cys Phe Pro Ala Ala Ala Phe His His Leu 
        355                 360                 365             
Asn Ala Gln Lys Ile Gln Asp Leu Trp Ser Tyr Glu Gln Lys Arg Trp 
    370                 375                 380                 
Gln Asp Lys Asp Lys Arg Val Leu Leu His Ser Asp Val Phe Arg Asp 
385                 390                 395                 400 
Leu Leu Tyr Pro Asp Ile Ala Leu Lys Pro Ala Arg Ile Gly Trp Asp 
                405                 410                 415     
Asn Leu Ser Ala Asp Glu Gln Ser Thr Ala Ser Ser Phe Glu Glu Cys 
            420                 425                 430         
Arg Gln Ile Cys Asp Gln Leu Asp Asp Cys Thr Gln Phe Ser Phe Arg 
        435                 440                 445             
Asp Lys Ser Cys Phe Thr Ser Arg Thr Pro Arg Leu Gly Ala Ala Asn 
    450                 455                 460                 
Pro Asn Thr Val Ser Gly Trp Met Val Asp Arg Ile Arg Ala Asn Met 
465                 470                 475                 480 
Glu Lys Ser Gly Leu Phe Ala Ala Trp Lys His Gly Leu Ser Gly Ile 
                485                 490                 495     
Trp Leu Ala Phe Glu Cys Leu Tyr Gln Ile Thr Tyr Phe Phe Leu Val 
            500                 505                 510         
Ile Tyr Leu Phe Ser Arg Leu Ala Val Glu Ala Asp Pro Arg Ala Gln 
        515                 520                 525             
Thr Ala Thr Val Ile Val Ser Thr Thr Val Ala Leu Ile Lys Cys Gly 
    530                 535                 540                 
Tyr Phe Ser Phe Arg Ala Lys Asp Ile Arg Ala Phe Tyr Phe Val Leu 
545                 550                 555                 560 
Tyr Thr Phe Val Tyr Phe Phe Cys Met Ile Pro Ala Arg Ile Thr Ala 
                565                 570                 575     
Met Met Thr Leu Trp Asp Ile Gly Trp Gly Thr Arg Gly Gly Asn Glu 
            580                 585                 590         
Lys Pro Ser Val Gly Thr Arg Val Ala Leu Trp Ala Lys Gln Tyr Leu 
        595                 600                 605             
Ile Ala Tyr Met Trp Trp Ala Ala Val Val Gly Ala Gly Val Tyr Ser 
    610                 615                 620                 
Ile Val His Asn Trp Met Phe Asp Trp Asn Ser Leu Ser Tyr Arg Phe 
625                 630                 635                 640 
Ala Leu Val Gly Ile Cys Ser Tyr Ile Val Phe Ile Val Ile Val Leu 
                645                 650                 655     
Val Val Tyr Phe Thr Gly Lys Ile Thr Thr Trp Asn Phe Thr Lys Leu 
            660                 665                 670         
Gln Lys Glu Leu Ile Glu Asp Arg Val Leu Tyr Asp Ala Thr Thr Asn 
        675                 680                 685             
Ala Gln Ser Val 
    690         

<210> 28
<211> 910
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of a polypeptide having chondroitin synthase
      activity (HCOS6-Vir)

<400> 28
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Leu Asp Ile Ala Thr Gln Leu Leu Leu Ser Asn Val 
                85                  90                  95      
Lys Lys Leu Thr Leu Ser Glu Ser Glu Lys Asn Ser Leu Lys Asn Lys 
            100                 105                 110         
Trp Lys Ser Ile Thr Gly Lys Lys Ser Glu Asn Ala Glu Ile Arg Lys 
        115                 120                 125             
Val Glu Leu Val Pro Lys Asp Phe Pro Lys Asp Leu Val Leu Ala Pro 
    130                 135                 140                 
Leu Pro Asp His Val Asn Asp Phe Thr Trp Tyr Lys Asn Arg Lys Lys 
145                 150                 155                 160 
Ser Leu Gly Ile Lys Pro Val Asn Lys Asn Ile Gly Leu Ser Ile Ile 
                165                 170                 175     
Ile Pro Thr Phe Asn Arg Ser Arg Ile Leu Asp Ile Thr Leu Ala Cys 
            180                 185                 190         
Leu Val Asn Gln Lys Thr Asn Tyr Pro Phe Glu Val Val Val Ala Asp 
        195                 200                 205             
Asp Gly Ser Lys Glu Asn Leu Leu Thr Ile Val Gln Lys Tyr Glu Gln 
    210                 215                 220                 
Lys Leu Asp Ile Lys Tyr Val Arg Gln Lys Asp Tyr Gly Tyr Gln Leu 
225                 230                 235                 240 
Cys Ala Val Arg Asn Leu Gly Leu Arg Thr Ala Lys Tyr Asp Phe Val 
                245                 250                 255     
Ser Ile Leu Asp Cys Asp Met Ala Pro Gln Gln Leu Trp Val His Ser 
            260                 265                 270         
Tyr Leu Thr Glu Leu Leu Glu Asp Asn Asp Ile Val Leu Ile Gly Pro 
        275                 280                 285             
Arg Lys Tyr Val Asp Thr His Asn Ile Thr Ala Glu Gln Phe Leu Asn 
    290                 295                 300                 
Asp Pro Tyr Leu Ile Glu Ser Leu Pro Glu Thr Ala Thr Asn Asn Asn 
305                 310                 315                 320 
Pro Ser Ile Thr Ser Lys Gly Asn Ile Ser Leu Asp Trp Arg Leu Glu 
                325                 330                 335     
His Phe Lys Lys Thr Asp Asn Leu Arg Leu Cys Asp Ser Pro Phe Arg 
            340                 345                 350         
Tyr Phe Ser Cys Gly Asn Val Ala Phe Ser Lys Glu Trp Leu Asn Lys 
        355                 360                 365             
Val Gly Trp Phe Asp Glu Glu Phe Asn His Trp Gly Gly Glu Asp Val 
    370                 375                 380                 
Glu Phe Gly Tyr Arg Leu Phe Ala Lys Gly Cys Phe Phe Arg Val Ile 
385                 390                 395                 400 
Asp Gly Gly Met Ala Tyr His Gln Glu Pro Pro Gly Lys Glu Asn Glu 
                405                 410                 415     
Thr Asp Arg Glu Ala Gly Lys Ser Ile Thr Leu Lys Ile Val Lys Glu 
            420                 425                 430         
Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile Glu Asp Ser His 
        435                 440                 445             
Ile His Arg Ile Pro Leu Val Ser Ile Tyr Ile Pro Ala Tyr Asn Cys 
    450                 455                 460                 
Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu Asn Gln Thr Val 
465                 470                 475                 480 
Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser Thr Asp Asn Thr 
                485                 490                 495     
Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro Arg Val Arg Ile 
            500                 505                 510         
Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser Asn Ala Ala Val 
        515                 520                 525             
Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp Ser Asp Asp Tyr 
    530                 535                 540                 
Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu Phe Leu Lys Asp 
545                 550                 555                 560 
Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn Val Asn Pro Asp 
                565                 570                 575     
Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Glu Phe Ser Arg Glu 
            580                 585                 590         
Lys Leu Thr Thr Ala Met Ile Ala His His Phe Arg Met Phe Thr Ile 
        595                 600                 605             
Arg Ala Trp His Leu Thr Asp Gly Phe Asn Glu Lys Ile Glu Asn Ala 
    610                 615                 620                 
Val Asp Tyr Asp Met Phe Leu Lys Leu Ser Glu Val Gly Lys Phe Lys 
625                 630                 635                 640 
His Leu Asn Lys Ile Cys Tyr Asn Arg Val Leu His Gly Asp Asn Thr 
                645                 650                 655     
Ser Ile Lys Asn Leu Asp Thr Gln Lys Lys Asn His Phe Val Val Val 
            660                 665                 670         
Asn Gln Ser Leu Asn Arg Gln Arg Val Ser Asn Tyr Asn Tyr Asp Glu 
        675                 680                 685             
Phe Asp Asn Leu Asp Glu Ser Arg Lys Tyr Ile Phe Asn Lys Leu Phe 
    690                 695                 700                 
Ala Ala Trp Lys His Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys 
705                 710                 715                 720 
Leu Tyr Gln Ile Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg 
                725                 730                 735     
Leu Ala Val Glu Ala Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val 
            740                 745                 750         
Ser Thr Thr Val Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala 
        755                 760                 765             
Lys Asp Ile Arg Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe 
    770                 775                 780                 
Phe Cys Met Ile Pro Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp 
785                 790                 795                 800 
Ile Gly Trp Gly Thr Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr 
                805                 810                 815     
Arg Val Ala Leu Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp 
            820                 825                 830         
Ala Ala Val Val Gly Ala Gly Val Tyr Ser Ile Val His Asn Trp Met 
        835                 840                 845             
Phe Asp Trp Asn Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys 
    850                 855                 860                 
Ser Tyr Ile Val Phe Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly 
865                 870                 875                 880 
Lys Ile Thr Thr Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu 
                885                 890                 895     
Asp Arg Val Leu Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
            900                 905                 910 

<210> 29
<211> 703
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS7-Vir)

<400> 29
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Ile Pro Thr Phe Asn Arg Ser Arg Ile Leu Asp Ile 
                85                  90                  95      
Thr Leu Ala Cys Leu Val Asn Gln Lys Thr Asn Tyr Pro Phe Glu Val 
            100                 105                 110         
Val Val Ala Asp Asp Gly Ser Lys Glu Asn Leu Leu Thr Ile Val Gln 
        115                 120                 125             
Lys Tyr Glu Gln Lys Leu Asp Ile Lys Tyr Val Arg Gln Lys Asp Tyr 
    130                 135                 140                 
Gly Tyr Gln Leu Cys Ala Val Arg Asn Leu Gly Leu Arg Thr Ala Lys 
145                 150                 155                 160 
Tyr Asp Phe Val Ser Ile Leu Asp Cys Asp Met Ala Pro Gln Gln Leu 
                165                 170                 175     
Trp Val His Ser Tyr Leu Thr Glu Leu Leu Glu Asp Asn Asp Ile Val 
            180                 185                 190         
Leu Ile Gly Pro Arg Lys Tyr Val Asp Thr His Asn Ile Thr Ala Glu 
        195                 200                 205             
Gln Phe Leu Asn Asp Pro Tyr Leu Ile Glu Ser Leu Pro Glu Thr Ala 
    210                 215                 220                 
Thr Asn Asn Asn Pro Ser Ile Thr Ser Lys Gly Asn Ile Ser Leu Asp 
225                 230                 235                 240 
Trp Arg Leu Glu His Phe Lys Lys Thr Asp Asn Leu Arg Leu Cys Asp 
                245                 250                 255     
Ser Pro Phe Arg Tyr Phe Ser Cys Gly Asn Val Ala Phe Ser Lys Glu 
            260                 265                 270         
Trp Leu Asn Lys Val Gly Trp Phe Asp Glu Glu Phe Asn His Trp Gly 
        275                 280                 285             
Gly Glu Asp Val Glu Phe Gly Tyr Arg Leu Phe Ala Lys Gly Cys Phe 
    290                 295                 300                 
Phe Arg Val Ile Asp Gly Gly Met Ala Tyr His Gln Glu Pro Pro Gly 
305                 310                 315                 320 
Lys Glu Asn Glu Thr Asp Arg Glu Ala Gly Lys Ser Ile Thr Leu Lys 
                325                 330                 335     
Ile Val Lys Glu Lys Val Pro Tyr Ile Tyr Arg Lys Leu Leu Pro Ile 
            340                 345                 350         
Glu Asp Ser His Ile His Arg Ile Pro Leu Val Ser Ile Tyr Ile Pro 
        355                 360                 365             
Ala Tyr Asn Cys Ala Asn Tyr Ile Gln Arg Cys Val Asp Ser Ala Leu 
    370                 375                 380                 
Asn Gln Thr Val Val Asp Leu Glu Val Cys Ile Cys Asn Asp Gly Ser 
385                 390                 395                 400 
Thr Asp Asn Thr Leu Glu Val Ile Asn Lys Leu Tyr Gly Asn Asn Pro 
                405                 410                 415     
Arg Val Arg Ile Met Ser Lys Pro Asn Gly Gly Ile Ala Ser Ala Ser 
            420                 425                 430         
Asn Ala Ala Val Ser Phe Ala Lys Gly Tyr Tyr Ile Gly Gln Leu Asp 
        435                 440                 445             
Ser Asp Asp Tyr Leu Glu Pro Asp Ala Val Glu Leu Cys Leu Lys Glu 
    450                 455                 460                 
Phe Leu Lys Asp Lys Thr Leu Ala Cys Val Tyr Thr Thr Asn Arg Asn 
465                 470                 475                 480 
Val Asn Pro Asp Gly Ser Leu Ile Ala Asn Gly Tyr Asn Trp Pro Leu 
                485                 490                 495     
Phe Ala Ala Trp Lys His Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu 
            500                 505                 510         
Cys Leu Tyr Gln Ile Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser 
        515                 520                 525             
Arg Leu Ala Val Glu Ala Asp Pro Arg Ala Gln Thr Ala Thr Val Ile 
    530                 535                 540                 
Val Ser Thr Thr Val Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg 
545                 550                 555                 560 
Ala Lys Asp Ile Arg Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr 
                565                 570                 575     
Phe Phe Cys Met Ile Pro Ala Arg Ile Thr Ala Met Met Thr Leu Trp 
            580                 585                 590         
Asp Ile Gly Trp Gly Thr Arg Gly Gly Asn Glu Lys Pro Ser Val Gly 
        595                 600                 605             
Thr Arg Val Ala Leu Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp 
    610                 615                 620                 
Trp Ala Ala Val Val Gly Ala Gly Val Tyr Ser Ile Val His Asn Trp 
625                 630                 635                 640 
Met Phe Asp Trp Asn Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile 
                645                 650                 655     
Cys Ser Tyr Ile Val Phe Ile Val Ile Val Leu Val Val Tyr Phe Thr 
            660                 665                 670         
Gly Lys Ile Thr Thr Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile 
        675                 680                 685             
Glu Asp Arg Val Leu Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
    690                 695                 700             

<210> 30
<211> 569
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS8-Vir)

<400> 30
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Gly Trp Asn Asp Val Arg Leu Ala Val Ile Ile Ala 
                85                  90                  95      
Gly Tyr Arg Glu Asp Pro Tyr Met Phe Gln Lys Cys Leu Glu Ser Val 
            100                 105                 110         
Arg Asp Ser Asp Tyr Gly Asn Val Ala Arg Leu Ile Cys Val Ile Asp 
        115                 120                 125             
Gly Asp Glu Asp Asp Asp Met Arg Met Ala Ala Val Tyr Lys Ala Ile 
    130                 135                 140                 
Tyr Asn Asp Asn Ile Lys Lys Pro Glu Phe Val Leu Cys Glu Ser Asp 
145                 150                 155                 160 
Asp Lys Glu Gly Glu Arg Ile Asp Ser Asp Phe Ser Arg Asp Ile Cys 
                165                 170                 175     
Val Leu Gln Pro His Arg Gly Lys Arg Glu Cys Leu Tyr Thr Gly Phe 
            180                 185                 190         
Gln Leu Ala Lys Met Asp Pro Ser Val Asn Ala Val Val Leu Ile Asp 
        195                 200                 205             
Ser Asp Thr Val Leu Glu Lys Asp Ala Ile Leu Glu Val Val Tyr Pro 
    210                 215                 220                 
Leu Ala Cys Asp Pro Glu Ile Gln Ala Val Ala Gly Glu Cys Lys Ile 
225                 230                 235                 240 
Trp Asn Thr Asp Thr Leu Leu Ser Leu Leu Val Ala Trp Arg Tyr Tyr 
                245                 250                 255     
Ser Ala Phe Cys Val Glu Arg Ser Ala Gln Ser Phe Phe Arg Thr Val 
            260                 265                 270         
Gln Cys Val Arg Leu Cys Asp Ser Pro Phe Arg Tyr Phe Ser Cys Gly 
        275                 280                 285             
Asn Val Ala Phe Ser Lys Glu Trp Leu Asn Lys Val Gly Trp Phe Asp 
    290                 295                 300                 
Glu Glu Phe Asn His Trp Gly Gly Glu Asp Val Glu Phe Gly Tyr Arg 
305                 310                 315                 320 
Leu Lys Lys Val Val Phe Thr Pro Phe Ala Val Gly Trp Ser Asp Ser 
                325                 330                 335     
Pro Thr Asn Val Phe Arg Tyr Ile Val Gln Gln Thr Arg Trp Ser Lys 
            340                 345                 350         
Ser Trp Cys Arg Glu Ile Trp Tyr Thr Leu Phe Ala Ala Trp Lys His 
        355                 360                 365             
Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr Gln Ile Thr 
    370                 375                 380                 
Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala Val Glu Ala 
385                 390                 395                 400 
Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr Thr Val Ala 
                405                 410                 415     
Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp Ile Arg Ala 
            420                 425                 430         
Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys Met Ile Pro 
        435                 440                 445             
Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly Trp Gly Thr 
    450                 455                 460                 
Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val Ala Leu Trp 
465                 470                 475                 480 
Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala Val Val Gly 
                485                 490                 495     
Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp Trp Asn Ser 
            500                 505                 510         
Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr Ile Val Phe 
        515                 520                 525             
Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile Thr Thr Trp 
    530                 535                 540                 
Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg Val Leu Tyr 
545                 550                 555                 560 
Asp Ala Thr Thr Asn Ala Gln Ser Val 
                565                 

<210> 31
<211> 832
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of a polypeptide having chondroitin synthase
      activity (HCOS9-Vir)

<400> 31
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys His Ile Gly Lys Cys Leu Arg Glu Met Tyr Thr Thr 
                85                  90                  95      
His Glu Asp Val Glu Val Gly Arg Cys Val Arg Arg Phe Ala Gly Val 
            100                 105                 110         
Gln Cys Val Trp Ser Tyr Glu Met Gln Gln Leu Phe Tyr Glu Asn Tyr 
        115                 120                 125             
Glu Gln Asn Lys Lys Gly Tyr Ile Arg Asp Leu His Asn Ser Lys Ile 
    130                 135                 140                 
His Gln Ala Ile Thr Leu His Pro Asn Lys Asn Pro Pro Tyr Gln Tyr 
145                 150                 155                 160 
Arg Leu His Ser Tyr Met Leu Ser Arg Lys Ile Ser Glu Leu Arg His 
                165                 170                 175     
Arg Thr Ile Gln Leu His Arg Glu Ile Val Leu Met Ser Lys Tyr Ser 
            180                 185                 190         
Asn Thr Glu Ile His Lys Glu Asp Leu Gln Leu Gly Ile Pro Pro Ser 
        195                 200                 205             
Phe Met Arg Phe Gln Pro Arg Gln Arg Glu Glu Ile Leu Glu Trp Glu 
    210                 215                 220                 
Phe Leu Thr Gly Lys Tyr Leu Tyr Ser Ala Val Asp Gly Gln Pro Pro 
225                 230                 235                 240 
Arg Arg Gly Met Asp Ser Ala Gln Arg Glu Ala Leu Asp Asp Ile Val 
                245                 250                 255     
Met Gln Val Met Glu Met Ile Asn Ala Asn Ala Lys Thr Arg Gly Arg 
            260                 265                 270         
Ile Ile Asp Phe Lys Glu Ile Gln Tyr Gly Tyr Arg Arg Val Asn Pro 
        275                 280                 285             
Met Tyr Gly Ala Glu Tyr Ile Leu Asp Leu Leu Leu Leu Tyr Lys Lys 
    290                 295                 300                 
His Lys Gly Lys Lys Met Thr Val Pro Val Arg Arg His Ala Tyr Leu 
305                 310                 315                 320 
Gln Gln Thr Phe Ser Lys Ile Gln Phe Val Glu His Glu Glu Leu Asp 
                325                 330                 335     
Ala Gln Glu Leu Ala Lys Arg Ile Asn Gln Glu Ser Gly Ser Leu Ser 
            340                 345                 350         
Phe Leu Ser Asn Ser Leu Lys Lys Leu Val Pro Phe Gln Leu Pro Gly 
        355                 360                 365             
Ser Lys Ser Glu His Lys Glu Pro Lys Asp Lys Lys Ile Asn Ile Leu 
    370                 375                 380                 
Ile Pro Leu Ser Gly Arg Phe Asp Met Phe Val Arg Phe Met Gly Asn 
385                 390                 395                 400 
Phe Glu Lys Thr Cys Leu Ile Pro Asn Gln Asn Val Lys Leu Val Val 
                405                 410                 415     
Leu Leu Phe Asn Ser Asp Ser Asn Pro Asp Lys Ala Lys Gln Val Glu 
            420                 425                 430         
Leu Met Arg Asp Tyr Arg Ile Lys Tyr Pro Lys Ala Asp Met Gln Ile 
        435                 440                 445             
Leu Pro Val Ser Gly Glu Phe Ser Arg Ala Leu Ala Leu Glu Val Gly 
    450                 455                 460                 
Ser Ser Gln Phe Asn Asn Glu Ser Leu Leu Phe Phe Cys Asp Val Asp 
465                 470                 475                 480 
Leu Val Phe Thr Thr Glu Phe Leu Gln Arg Cys Arg Ala Asn Thr Val 
                485                 490                 495     
Leu Gly Gln Gln Ile Tyr Phe Pro Ile Ile Phe Ser Gln Tyr Asp Pro 
            500                 505                 510         
Lys Ile Val Tyr Ser Gly Lys Val Pro Ser Asp Asn His Phe Ala Phe 
        515                 520                 525             
Thr Gln Lys Thr Gly Phe Trp Arg Asn Tyr Gly Phe Gly Ile Thr Cys 
    530                 535                 540                 
Ile Tyr Lys Gly Asp Leu Val Arg Val Gly Gly Phe Asp Val Ser Ile 
545                 550                 555                 560 
Gln Gly Trp Gly Leu Glu Asp Val Asp Leu Phe Asn Lys Val Val Gln 
                565                 570                 575     
Ala Gly Leu Lys Thr Phe Arg Ser Gln Glu Val Gly Val Val His Val 
            580                 585                 590         
His His Pro Val Phe Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys 
        595                 600                 605             
Met Cys Leu Gly Ser Lys Ala Ser Thr Tyr Gly Ser Thr Gln Gln Leu 
    610                 615                 620                 
Leu Phe Ala Ala Trp Lys His Gly Leu Ser Gly Ile Trp Leu Ala Phe 
625                 630                 635                 640 
Glu Cys Leu Tyr Gln Ile Thr Tyr Phe Phe Leu Val Ile Tyr Leu Phe 
                645                 650                 655     
Ser Arg Leu Ala Val Glu Ala Asp Pro Arg Ala Gln Thr Ala Thr Val 
            660                 665                 670         
Ile Val Ser Thr Thr Val Ala Leu Ile Lys Cys Gly Tyr Phe Ser Phe 
        675                 680                 685             
Arg Ala Lys Asp Ile Arg Ala Phe Tyr Phe Val Leu Tyr Thr Phe Val 
    690                 695                 700                 
Tyr Phe Phe Cys Met Ile Pro Ala Arg Ile Thr Ala Met Met Thr Leu 
705                 710                 715                 720 
Trp Asp Ile Gly Trp Gly Thr Arg Gly Gly Asn Glu Lys Pro Ser Val 
                725                 730                 735     
Gly Thr Arg Val Ala Leu Trp Ala Lys Gln Tyr Leu Ile Ala Tyr Met 
            740                 745                 750         
Trp Trp Ala Ala Val Val Gly Ala Gly Val Tyr Ser Ile Val His Asn 
        755                 760                 765             
Trp Met Phe Asp Trp Asn Ser Leu Ser Tyr Arg Phe Ala Leu Val Gly 
    770                 775                 780                 
Ile Cys Ser Tyr Ile Val Phe Ile Val Ile Val Leu Val Val Tyr Phe 
785                 790                 795                 800 
Thr Gly Lys Ile Thr Thr Trp Asn Phe Thr Lys Leu Gln Lys Glu Leu 
                805                 810                 815     
Ile Glu Asp Arg Val Leu Tyr Asp Ala Thr Thr Asn Ala Gln Ser Val 
            820                 825                 830         



<210> 32
<211> 1001
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS10-Vir)

<400> 32
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Thr 
                85                  90                  95      
Ala Gln Lys Tyr Leu Gln Thr Arg Ala Val Ala Ala Tyr Arg Thr Trp 
            100                 105                 110         
Ser Lys Thr Ile Pro Gly Lys Val Gln Phe Phe Ser Ser Glu Gly Ser 
        115                 120                 125             
Asp Thr Ser Val Pro Ile Pro Val Val Pro Leu Arg Gly Val Asp Asp 
    130                 135                 140                 
Ser Tyr Pro Pro Gln Lys Lys Ser Phe Met Met Leu Lys Tyr Met His 
145                 150                 155                 160 
Asp His Tyr Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp 
                165                 170                 175     
Val Tyr Ile Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn 
            180                 185                 190         
Ser Ser Glu Pro Leu Phe Leu Gly Gln Thr Gly Leu Gly Thr Thr Glu 
        195                 200                 205             
Glu Met Gly Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly 
    210                 215                 220                 
Gly Pro Gly Val Ile Met Ser Arg Glu Val Leu Arg Arg Met Val Pro 
225                 230                 235                 240 
His Ile Gly Lys Cys Leu Arg Glu Met Tyr Thr Thr His Glu Asp Val 
                245                 250                 255     
Glu Val Gly Arg Cys Val Arg Arg Phe Ala Gly Val Gln Cys Val Trp 
            260                 265                 270         
Ser Tyr Glu Met Gln Gln Leu Phe Tyr Glu Asn Tyr Glu Gln Asn Lys 
        275                 280                 285             
Lys Gly Tyr Ile Arg Asp Leu His Asn Ser Lys Ile His Gln Ala Ile 
    290                 295                 300                 
Thr Leu His Pro Asn Lys Asn Pro Pro Tyr Gln Tyr Arg Leu His Ser 
305                 310                 315                 320 
Tyr Met Leu Ser Arg Lys Ile Ser Glu Leu Arg His Arg Thr Ile Gln 
                325                 330                 335     
Leu His Arg Glu Ile Val Leu Met Ser Lys Tyr Ser Asn Thr Glu Ile 
            340                 345                 350         
His Lys Glu Asp Leu Gln Leu Gly Ile Pro Pro Ser Phe Met Arg Phe 
        355                 360                 365             
Gln Pro Arg Gln Arg Glu Glu Ile Leu Glu Trp Glu Phe Leu Thr Gly 
    370                 375                 380                 
Lys Tyr Leu Tyr Ser Ala Val Asp Gly Gln Pro Pro Arg Arg Gly Met 
385                 390                 395                 400 
Asp Ser Ala Gln Arg Glu Ala Leu Asp Asp Ile Val Met Gln Val Met 
                405                 410                 415     
Glu Met Ile Asn Ala Asn Ala Lys Thr Arg Gly Arg Ile Ile Asp Phe 
            420                 425                 430         
Lys Glu Ile Gln Tyr Gly Tyr Arg Arg Val Asn Pro Met Tyr Gly Ala 
        435                 440                 445             
Glu Tyr Ile Leu Asp Leu Leu Leu Leu Tyr Lys Lys His Lys Gly Lys 
    450                 455                 460                 
Lys Met Thr Val Pro Val Arg Arg His Ala Tyr Leu Gln Gln Thr Phe 
465                 470                 475                 480 
Ser Lys Ile Gln Phe Val Glu His Glu Glu Leu Asp Ala Gln Glu Leu 
                485                 490                 495     
Ala Lys Arg Ile Asn Gln Glu Ser Gly Ser Leu Ser Phe Leu Ser Asn 
            500                 505                 510         
Ser Leu Lys Lys Leu Val Pro Phe Gln Leu Pro Gly Ser Lys Ser Glu 
        515                 520                 525             
His Lys Glu Pro Lys Asp Lys Lys Ile Asn Ile Leu Ile Pro Leu Ser 
    530                 535                 540                 
Gly Arg Phe Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Thr 
545                 550                 555                 560 
Cys Leu Ile Pro Asn Gln Asn Val Lys Leu Val Val Leu Leu Phe Asn 
                565                 570                 575     
Ser Asp Ser Asn Pro Asp Lys Ala Lys Gln Val Glu Leu Met Arg Asp 
            580                 585                 590         
Tyr Arg Ile Lys Tyr Pro Lys Ala Asp Met Gln Ile Leu Pro Val Ser 
        595                 600                 605             
Gly Glu Phe Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gln Phe 
    610                 615                 620                 
Asn Asn Glu Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Thr 
625                 630                 635                 640 
Thr Glu Phe Leu Gln Arg Cys Arg Ala Asn Thr Val Leu Gly Gln Gln 
                645                 650                 655     
Ile Tyr Phe Pro Ile Ile Phe Ser Gln Tyr Asp Pro Lys Ile Val Tyr 
            660                 665                 670         
Ser Gly Lys Val Pro Ser Asp Asn His Phe Ala Phe Thr Gln Lys Thr 
        675                 680                 685             
Gly Phe Trp Arg Asn Tyr Gly Phe Gly Ile Thr Cys Ile Tyr Lys Gly 
    690                 695                 700                 
Asp Leu Val Arg Val Gly Gly Phe Asp Val Ser Ile Gln Gly Trp Gly 
705                 710                 715                 720 
Leu Glu Asp Val Asp Leu Phe Asn Lys Val Val Gln Ala Gly Leu Lys 
                725                 730                 735     
Thr Phe Arg Ser Gln Glu Val Gly Val Val His Val His His Pro Val 
            740                 745                 750         
Phe Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys Met Cys Leu Gly 
        755                 760                 765             
Ser Lys Ala Ser Thr Tyr Gly Ser Thr Gln Gln Leu Ala Glu Met Trp 
    770                 775                 780                 
Leu Glu Lys Asn Asp Pro Ser Tyr Ser Leu Phe Ala Ala Trp Lys His 
785                 790                 795                 800 
Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr Gln Ile Thr 
                805                 810                 815     
Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala Val Glu Ala 
            820                 825                 830         
Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr Thr Val Ala 
        835                 840                 845             
Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp Ile Arg Ala 
    850                 855                 860                 
Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys Met Ile Pro 
865                 870                 875                 880 
Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly Trp Gly Thr 
                885                 890                 895     
Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val Ala Leu Trp 
            900                 905                 910         
Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala Val Val Gly 
        915                 920                 925             
Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp Trp Asn Ser 
    930                 935                 940                 
Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr Ile Val Phe 
945                 950                 955                 960 
Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile Thr Thr Trp 
                965                 970                 975     
Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg Val Leu Tyr 
            980                 985                 990         
Asp Ala Thr Thr Asn Ala Gln Ser Val 
        995                 1000    

<210> 33
<211> 531
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS11-Vir)

<400> 33
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Arg Asp Arg Asn Phe Leu Phe Val Gly Val Met Thr 
                85                  90                  95      
Ala Gln Lys Tyr Leu Gln Thr Arg Ala Val Ala Ala Tyr Arg Thr Trp 
            100                 105                 110         
Ser Lys Thr Ile Pro Gly Lys Val Gln Phe Phe Ser Ser Glu Gly Ser 
        115                 120                 125             
Asp Thr Ser Val Pro Ile Pro Val Val Pro Leu Arg Gly Val Asp Asp 
    130                 135                 140                 
Ser Tyr Pro Pro Gln Lys Lys Ser Phe Met Met Leu Lys Tyr Met His 
145                 150                 155                 160 
Asp His Tyr Leu Asp Lys Tyr Glu Trp Phe Met Arg Ala Asp Asp Asp 
                165                 170                 175     
Val Tyr Ile Lys Gly Asp Arg Leu Glu Asn Phe Leu Arg Ser Leu Asn 
            180                 185                 190         
Ser Ser Glu Pro Leu Phe Leu Gly Gln Thr Gly Leu Gly Thr Thr Glu 
        195                 200                 205             
Glu Met Gly Lys Leu Ala Leu Glu Pro Gly Glu Asn Phe Cys Met Gly 
    210                 215                 220                 
Gly Pro Gly Val Ile Met Ser Arg Glu Val Leu Arg Arg Met Val Pro 
225                 230                 235                 240 
His Ile Gly Lys Cys Leu Arg Glu Met Tyr Thr Thr His Glu Asp Val 
                245                 250                 255     
Glu Val Gly Arg Cys Val Arg Arg Phe Ala Gly Val Gln Cys Val Trp 
            260                 265                 270         
Ser Tyr Glu Met Gln Gln Leu Phe Tyr Glu Asn Tyr Glu Gln Asn Lys 
        275                 280                 285             
Lys Gly Tyr Ile Arg Asp Leu His Asn Ser Lys Ile His Gln Ala Ile 
    290                 295                 300                 
Thr Leu His Pro Asn Lys Asn Pro Pro Tyr Gln Tyr Arg Leu His Ser 
305                 310                 315                 320 
Tyr Met Leu Leu Phe Ala Ala Trp Lys His Gly Leu Ser Gly Ile Trp 
                325                 330                 335     
Leu Ala Phe Glu Cys Leu Tyr Gln Ile Thr Tyr Phe Phe Leu Val Ile 
            340                 345                 350         
Tyr Leu Phe Ser Arg Leu Ala Val Glu Ala Asp Pro Arg Ala Gln Thr 
        355                 360                 365             
Ala Thr Val Ile Val Ser Thr Thr Val Ala Leu Ile Lys Cys Gly Tyr 
    370                 375                 380                 
Phe Ser Phe Arg Ala Lys Asp Ile Arg Ala Phe Tyr Phe Val Leu Tyr 
385                 390                 395                 400 
Thr Phe Val Tyr Phe Phe Cys Met Ile Pro Ala Arg Ile Thr Ala Met 
                405                 410                 415     
Met Thr Leu Trp Asp Ile Gly Trp Gly Thr Arg Gly Gly Asn Glu Lys 
            420                 425                 430         
Pro Ser Val Gly Thr Arg Val Ala Leu Trp Ala Lys Gln Tyr Leu Ile 
        435                 440                 445             
Ala Tyr Met Trp Trp Ala Ala Val Val Gly Ala Gly Val Tyr Ser Ile 
    450                 455                 460                 
Val His Asn Trp Met Phe Asp Trp Asn Ser Leu Ser Tyr Arg Phe Ala 
465                 470                 475                 480 
Leu Val Gly Ile Cys Ser Tyr Ile Val Phe Ile Val Ile Val Leu Val 
                485                 490                 495     
Val Tyr Phe Thr Gly Lys Ile Thr Thr Trp Asn Phe Thr Lys Leu Gln 
            500                 505                 510         
Lys Glu Leu Ile Glu Asp Arg Val Leu Tyr Asp Ala Thr Thr Asn Ala 
        515                 520                 525             
Gln Ser Val 
    530     

<210> 34
<211> 553
<212> PRT
<213> other sequences


<220> 
<223> reencoded amino acid sequence of a polypeptide having chondroitin
      synthase activity (HCOS12-Vir)

<400> 34
Met Gly Lys Asn Ile Ile Ile Met Val Ser Trp Tyr Thr Ile Ile Thr 
1               5                   10                  15      
Ser Asn Leu Ile Ala Val Gly Gly Ala Ser Leu Ile Leu Ala Pro Ala 
            20                  25                  30          
Ile Thr Gly Tyr Val Leu His Trp Asn Ile Ala Leu Ser Thr Ile Trp 
        35                  40                  45              
Gly Val Ser Ala Tyr Gly Ile Phe Val Phe Gly Phe Phe Leu Ala Gln 
    50                  55                  60                  
Val Leu Phe Ser Glu Leu Asn Arg Lys Arg Leu Arg Lys Trp Ile Ser 
65                  70                  75                  80  
Leu Arg Pro Lys Lys Asp Lys Lys Ile Asn Ile Leu Ile Pro Leu Ser 
                85                  90                  95      
Gly Arg Phe Asp Met Phe Val Arg Phe Met Gly Asn Phe Glu Lys Thr 
            100                 105                 110         
Cys Leu Ile Pro Asn Gln Asn Val Lys Leu Val Val Leu Leu Phe Asn 
        115                 120                 125             
Ser Asp Ser Asn Pro Asp Lys Ala Lys Gln Val Glu Leu Met Arg Asp 
    130                 135                 140                 
Tyr Arg Ile Lys Tyr Pro Lys Ala Asp Met Gln Ile Leu Pro Val Ser 
145                 150                 155                 160 
Gly Glu Phe Ser Arg Ala Leu Ala Leu Glu Val Gly Ser Ser Gln Phe 
                165                 170                 175     
Asn Asn Glu Ser Leu Leu Phe Phe Cys Asp Val Asp Leu Val Phe Thr 
            180                 185                 190         
Thr Glu Phe Leu Gln Arg Cys Arg Ala Asn Thr Val Leu Gly Gln Gln 
        195                 200                 205             
Ile Tyr Phe Pro Ile Ile Phe Ser Gln Tyr Asp Pro Lys Ile Val Tyr 
    210                 215                 220                 
Ser Gly Lys Val Pro Ser Asp Asn His Phe Ala Phe Thr Gln Lys Thr 
225                 230                 235                 240 
Gly Phe Trp Arg Asn Tyr Gly Phe Gly Ile Thr Cys Ile Tyr Lys Gly 
                245                 250                 255     
Asp Leu Val Arg Val Gly Gly Phe Asp Val Ser Ile Gln Gly Trp Gly 
            260                 265                 270         
Leu Glu Asp Val Asp Leu Phe Asn Lys Val Val Gln Ala Gly Leu Lys 
        275                 280                 285             
Thr Phe Arg Ser Gln Glu Val Gly Val Val His Val His His Pro Val 
    290                 295                 300                 
Phe Cys Asp Pro Asn Leu Asp Pro Lys Gln Tyr Lys Met Cys Leu Gly 
305                 310                 315                 320 
Ser Lys Ala Ser Thr Tyr Gly Ser Thr Gln Gln Leu Ala Glu Met Trp 
                325                 330                 335     
Leu Glu Lys Asn Asp Pro Ser Tyr Ser Leu Phe Ala Ala Trp Lys His 
            340                 345                 350         
Gly Leu Ser Gly Ile Trp Leu Ala Phe Glu Cys Leu Tyr Gln Ile Thr 
        355                 360                 365             
Tyr Phe Phe Leu Val Ile Tyr Leu Phe Ser Arg Leu Ala Val Glu Ala 
    370                 375                 380                 
Asp Pro Arg Ala Gln Thr Ala Thr Val Ile Val Ser Thr Thr Val Ala 
385                 390                 395                 400 
Leu Ile Lys Cys Gly Tyr Phe Ser Phe Arg Ala Lys Asp Ile Arg Ala 
                405                 410                 415     
Phe Tyr Phe Val Leu Tyr Thr Phe Val Tyr Phe Phe Cys Met Ile Pro 
            420                 425                 430         
Ala Arg Ile Thr Ala Met Met Thr Leu Trp Asp Ile Gly Trp Gly Thr 
        435                 440                 445             
Arg Gly Gly Asn Glu Lys Pro Ser Val Gly Thr Arg Val Ala Leu Trp 
    450                 455                 460                 
Ala Lys Gln Tyr Leu Ile Ala Tyr Met Trp Trp Ala Ala Val Val Gly 
465                 470                 475                 480 
Ala Gly Val Tyr Ser Ile Val His Asn Trp Met Phe Asp Trp Asn Ser 
                485                 490                 495     
Leu Ser Tyr Arg Phe Ala Leu Val Gly Ile Cys Ser Tyr Ile Val Phe 
            500                 505                 510         
Ile Val Ile Val Leu Val Val Tyr Phe Thr Gly Lys Ile Thr Thr Trp 
        515                 520                 525             
Asn Phe Thr Lys Leu Gln Lys Glu Leu Ile Glu Asp Arg Val Leu Tyr 
    530                 535                 540                 
Asp Ala Thr Thr Asn Ala Gln Ser Val 
545                 550             

<210> 35
<211> 1446
<212> DNA
<213> Arabidopsis thaliana


<220> 
<223> nucleic acid sequence of UDP-Glucose dehydrogenase (HASB)

<400> 35
atggtcaaaa tatgctgtat cggggctgga tatgtcggtg ggcctacaat ggccgttatg      60

gccctaaagt gtccagagat tgaagtcgtg gtagttgata tatcggagcc acgaattaac     120

gcatggaact cagaccgtct accaatttat gagccagggt tagaggatgt cgtcaaacag     180

tgtagaggga agaatttgtt cttctctaca gatgtagaga agcatgtatt tgagtcagat     240

atagtgtttg tttcggtaaa cactcctacg aaaacgcagg gtctgggtgc aggtaaagca     300

gcagatttga catattggga gtccgctgct cgcatgatag ctgatgtgag caaatcgtcg     360

aaaatcgtcg ttgaaaagag tacagtacca gttcgtacag ccgaggctat agaaaagatt     420

ttaacgcaca attcgaaggg tatcgaattc cagatcttat caaatccaga attcttggcc     480

gaagggacgg cgattaaaga cttatataac cctgatagag ttctaatcgg tggcagggac     540

accgctgcgg gacaaaaggc cattaaggcg ttgcgtgacg tgtatgccca ctgggttcct     600

gttgagcaaa taatctgtac taatttatgg agtgccgagc tatcaaagtt ggctgcgaac     660

gcatttctag ctcaaaggat aagttcagta aacgcaatgt cagcgctttg tgaggcaact     720

ggtgctgacg taacccaagt cgctcacgcc gttggaaccg acactagaat tggaccgaag     780

tttcttaacg catccgtagg cttcggcgga tcttgctttc agaaagacat cctgaatctt     840

atttacatct gcgaatgcaa tggtcttcca gaagcagcca attattggaa acaggtagtc     900

aaggtaaatg actaccaaaa gattaggttt gctaatcgag tcgtatcttc tatgttcaac     960

accgtctccg gtaagaaaat tgctattttg ggatttgcgt tcaagaagga caccggcgac    1020

acgcgtgaaa ctcctgccat agatgtgtgt aatcgcctcg tggctgataa agcaaagctg    1080

tcgatctatg atccgcaagt attagaagag cagatccgcc gtgatctgtc catggcccga    1140

ttcgattggg accatccagt cccactccag cagatcaaag ctgaaggtat ctccgaacag    1200

gttaacgttg tgtccgacgc ctacgaggct acgaaggatg ctcatggttt atgtgtttta    1260

accgaatggg acgaattcaa gtcacttgat tttaagaaga tctttgataa tatgcagaaa    1320

cccgctttcg ttttcgacgg aagaaacgtg gtcgacgctg tgaaattgag agaaattgga    1380

ttcatagtat attccatagg taaacctctg gatagttggc tcaaggatat gccggctgtt    1440

gcataa                                                               1446


<210> 36
<211> 1166
<212> DNA
<213> Chlorella virus


<220> 
<223> reencoded nucleic acid sequence of UDP-Glucose dehydrogenase
      (HASB)

<400> 36
atgagtagaa ttgctgtcgt tggatgcggt tacgtgggta cggcctgcgc cgtacttttg      60

gcgcagaaga acgaagttat cgttttggat atctcggagg accgggtaca actgattaag     120

aataagaagt cacctataga agataaggaa atcgaagaat tcctggagac gaaagatttg     180

aatctaacag cgacgacgga taaggtgctc gcctatgaga atgctgaatt cgttataata     240

gctacaccga ccgattacga tgtcgtcact agatatttca acactaagtc tgttgaaaat     300

gtgataggcg atgtcattaa gaacactcag acacacccta ctatagtgat caagagtact     360

attccaatcg gtttcgtgga taaagttaga gaacagttcg attatcaaaa tattatcttc     420

tcgccggaat tcttgagaga aggacgagca ttatatgata atctttaccc ctcccgtatc     480

atcgtcggtg atgactcccc aattgcctta aaattcgcga atctcttggt cgagggtagc     540

aaaactccac tagctcccgt attaactatg ggtacgcgag aggccgaagc tgtaaaacta     600

ttttcaaata catatttggc tatgagagta gcatacttca atgagctaga cacatttgca     660

atgtcccatg gtatgaacgc aaaagagatt atcgacggag tcacactaga accaaggata     720

gggcagggtt attcgaatcc ttcatttggg tatggagcct attgtttccc aaaagataca     780

aagcaattgt tggctaattt tgaaggggtt ccacaagata ttattggcgc aatcgtagag     840

tctaacgaaa ctagaaagga ggttattgtt tctgaggtcg agaacagatt tccgaccaca     900

gttggcgtat ataagttggc tgctaaagct ggttcggata atttcaggtc tagtgcgata     960

gtcgatatca tggaaaggtt ggctaataag ggctaccaca tcaaaatatt tgaacctacc    1020

gttgaacaat ttgagaattt tgaggtagat aataatctca caacttttgc aaccgagtct    1080

gatgtaataa ttgcgaacag agttccagtc gaacatcgca ttctgtttgg gaagaagtta    1140

ataacacggg atgtctatgg ggataa                                         1166


<210> 37
<211> 1170
<212> DNA
<213> Chlorella virus


<220> 
<223> reencoded nucleic acid sequence of UDP-Glucose dehydrogenase
      (HASB-A)

<400> 37
atgtcacgaa tcgcagtagt tggctgtggg tacgtgggaa ccgcatgcgc tgtactgctg      60

gcgcaaaaga atgaggtaat cgttcttgat attagtgagg atagggtcca actaatcaag     120

aacaagaaat ccccgatcga agataaggag attgaagaat tcttggaaac aaaagaccta     180

aacttaactg caacaactga caaagtttta gcctacgaaa acgctgagtt tgtgattata     240

gcgacaccca cagattatga cgtagttacc agatacttta acacgaagtc cgtagagaac     300

gtcattggag atgttataaa gaatactcag actcatccta cgatagtaat aaagtcaacc     360

attcccatag gtttcgtaga taaggttagg gagcaattcg attaccagaa cattatattt     420

tcgccagaat ttctgagaga gggtcgcgcc ctgtatgata atctatatcc atcacggatt     480

atagtgggcg atgactctcc gattgcactt aagtttgcta atcttttagt tgagggctcc     540

aaaactccgc tcgccccagt acttacgatg ggtacacgtg aggctgaagc tgtcaagctg     600

ttttcaaaca cataccttgc tatgcgagtc gcatacttta acgaactaga tacctttgct     660

atgtcgcacg gtatgaatgc taaagaaatc atagatggcg taacgttgga gcctcggata     720

ggtcaaggat attccaatcc atcttttggc tacggtgcgt attgtttccc aaaggacacg     780

aagcaattat tagctaactt tgagggtgtt ccgcaagata taattggggc gatagtagaa     840

agcaatgaaa cacggaagga ggtaatcgtg agtgaagtgg aaaaccgatt ccccactacg     900

gtcggcgttt acaaattagc cgccaaggct ggttccgaca atttccgatc cagcgcaata     960

gtagatatta tggaaagatt agctaataag ggataccaca ttaaaatctt tgaacctact    1020

gtcgaacagt tcgagaactt cgaggttgat aataacttga cgactttcgc aacggagagc    1080

gatgtaatta ttgcaaaccg cgtacctgtg gaacatcgaa ttttgttcgg aaagaagctg    1140

attacacgcg atgtatatgg cgataactaa                                     1170


<210> 38
<211> 1199
<212> DNA
<213> Streptococcus


<220> 
<223> a nucleic acid sequence of UDP-Glucose dehydrogenase (HASB)

<400> 38
atgaagatat cggtagcggg ttcggggtac gtggggttat ccttgtcaat cttgcttgcc      60

caacataacg atgtgactgt tgtagatata atcgacgaaa aggtacggct aattaaccag     120

ggcatatctc cgattaagga tgcggacatt gaggaatatc tgaagaatgc accgttgaat     180

cttacggcta cactagacgg agcttcggct tatagtaatg ctgatctgat tataatcgca     240

acgccaacta attacgattc agaacgcaat tatttcgaca ccagacacgt tgaagaagta     300

attgagcaag tattggattt aaatgcctcc gctactataa tcatcaagag taccataccc     360

ttgggtttta ttaaacacgt aagagagaaa taccaaacag acagaatcat cttttctcca     420

gagttcttaa gagagtcaaa ggcattgtac gataacttat acccctctcg tataatagtc     480

agttatgaga aggatgactc tccaagagtt atacaagcag ctaaggcgtt cgcgggttta     540

ttaaaagagg gggcaaagag caaggatacc ccagttctgt ttatgggctc tcaagaagct     600

gaagctgtca agctgtttgc taatactttt ctcgccatga gggtcagtta cttcaacgag     660

cttgacactt atagcgaatc aaaaggacta gacgcccaaa gagttataga aggcgtctgc     720

catgatcaaa ggataggtaa tcattacaat aatccatcct tcggatatgg cggttattgt     780

ttacccaaag actcaaagca acttttggct aattatagag gcatacctca gtctctaatg     840

tctgccatcg ttgaatcgaa caagatccgt aagtcgtatt tagctgaaca aatattagat     900

agggcttctt cacaaaagca ggctggtgta cctttaacca taggatttta ccgtttgatt     960

atgaagtcca actccgataa ctttagagaa tcagccatta aagatattat tgacatcatt    1020

aatgactacg gtgtcaatat tgtcatttat gaacctatgt tgggagaaga cattggttat    1080

agagtcgtta aagatttgga acagtttaag aacgaaagta caattattgt tagtaacagg    1140

tttgaagatg atttaggtga tgttattgat aaagtttata cacgtgacgt ctttggtag     1199


<210> 39
<211> 481
<212> PRT
<213> Arabidopsis thaliana


<220> 
<223> amino acid sequence of UDP-Glucose dehydrogenase (HASB)

<400> 39
Met Val Lys Ile Cys Cys Ile Gly Ala Gly Tyr Val Gly Gly Pro Thr 
1               5                   10                  15      
Met Ala Val Met Ala Leu Lys Cys Pro Glu Ile Glu Val Val Val Val 
            20                  25                  30          
Asp Ile Ser Glu Pro Arg Ile Asn Ala Trp Asn Ser Asp Arg Leu Pro 
        35                  40                  45              
Ile Tyr Glu Pro Gly Leu Glu Asp Val Val Lys Gln Cys Arg Gly Lys 
    50                  55                  60                  
Asn Leu Phe Phe Ser Thr Asp Val Glu Lys His Val Phe Glu Ser Asp 
65                  70                  75                  80  
Ile Val Phe Val Ser Val Asn Thr Pro Thr Lys Thr Gln Gly Leu Gly 
                85                  90                  95      
Ala Gly Lys Ala Ala Asp Leu Thr Tyr Trp Glu Ser Ala Ala Arg Met 
            100                 105                 110         
Ile Ala Asp Val Ser Lys Ser Ser Lys Ile Val Val Glu Lys Ser Thr 
        115                 120                 125             
Val Pro Val Arg Thr Ala Glu Ala Ile Glu Lys Ile Leu Thr His Asn 
    130                 135                 140                 
Ser Lys Gly Ile Glu Phe Gln Ile Leu Ser Asn Pro Glu Phe Leu Ala 
145                 150                 155                 160 
Glu Gly Thr Ala Ile Lys Asp Leu Tyr Asn Pro Asp Arg Val Leu Ile 
                165                 170                 175     
Gly Gly Arg Asp Thr Ala Ala Gly Gln Lys Ala Ile Lys Ala Leu Arg 
            180                 185                 190         
Asp Val Tyr Ala His Trp Val Pro Val Glu Gln Ile Ile Cys Thr Asn 
        195                 200                 205             
Leu Trp Ser Ala Glu Leu Ser Lys Leu Ala Ala Asn Ala Phe Leu Ala 
    210                 215                 220                 
Gln Arg Ile Ser Ser Val Asn Ala Met Ser Ala Leu Cys Glu Ala Thr 
225                 230                 235                 240 
Gly Ala Asp Val Thr Gln Val Ala His Ala Val Gly Thr Asp Thr Arg 
                245                 250                 255     
Ile Gly Pro Lys Phe Leu Asn Ala Ser Val Gly Phe Gly Gly Ser Cys 
            260                 265                 270         
Phe Gln Lys Asp Ile Leu Asn Leu Ile Tyr Ile Cys Glu Cys Asn Gly 
        275                 280                 285             
Leu Pro Glu Ala Ala Asn Tyr Trp Lys Gln Val Val Lys Val Asn Asp 
    290                 295                 300                 
Tyr Gln Lys Ile Arg Phe Ala Asn Arg Val Val Ser Ser Met Phe Asn 
305                 310                 315                 320 
Thr Val Ser Gly Lys Lys Ile Ala Ile Leu Gly Phe Ala Phe Lys Lys 
                325                 330                 335     
Asp Thr Gly Asp Thr Arg Glu Thr Pro Ala Ile Asp Val Cys Asn Arg 
            340                 345                 350         
Leu Val Ala Asp Lys Ala Lys Leu Ser Ile Tyr Asp Pro Gln Val Leu 
        355                 360                 365             
Glu Glu Gln Ile Arg Arg Asp Leu Ser Met Ala Arg Phe Asp Trp Asp 
    370                 375                 380                 
His Pro Val Pro Leu Gln Gln Ile Lys Ala Glu Gly Ile Ser Glu Gln 
385                 390                 395                 400 
Val Asn Val Val Ser Asp Ala Tyr Glu Ala Thr Lys Asp Ala His Gly 
                405                 410                 415     
Leu Cys Val Leu Thr Glu Trp Asp Glu Phe Lys Ser Leu Asp Phe Lys 
            420                 425                 430         
Lys Ile Phe Asp Asn Met Gln Lys Pro Ala Phe Val Phe Asp Gly Arg 
        435                 440                 445             
Asn Val Val Asp Ala Val Lys Leu Arg Glu Ile Gly Phe Ile Val Tyr 
    450                 455                 460                 
Ser Ile Gly Lys Pro Leu Asp Ser Trp Leu Lys Asp Met Pro Ala Val 
465                 470                 475                 480 
Ala 
    

<210> 40
<211> 389
<212> PRT
<213> Chlorella virus


<220> 
<223> amino acid sequence of UDP-Glucose dehydrogenase (HASB)

<400> 40
Met Ser Arg Ile Ala Val Val Gly Cys Gly Tyr Val Gly Thr Ala Cys 
1               5                   10                  15      
Ala Val Leu Leu Ala Gln Lys Asn Glu Val Ile Val Leu Asp Ile Ser 
            20                  25                  30          
Glu Asp Arg Val Gln Leu Ile Lys Asn Lys Lys Ser Pro Ile Glu Asp 
        35                  40                  45              
Lys Glu Ile Glu Glu Phe Leu Glu Thr Lys Asp Leu Asn Leu Thr Ala 
    50                  55                  60                  
Thr Thr Asp Lys Val Leu Ala Tyr Glu Asn Ala Glu Phe Val Ile Ile 
65                  70                  75                  80  
Ala Thr Pro Thr Asp Tyr Asp Val Val Thr Arg Tyr Phe Asn Thr Lys 
                85                  90                  95      
Ser Val Glu Asn Val Ile Gly Asp Val Ile Lys Asn Thr Gln Thr His 
            100                 105                 110         
Pro Thr Ile Val Ile Lys Ser Thr Ile Pro Ile Gly Phe Val Asp Lys 
        115                 120                 125             
Val Arg Glu Gln Phe Asp Tyr Gln Asn Ile Ile Phe Ser Pro Glu Phe 
    130                 135                 140                 
Leu Arg Glu Gly Arg Ala Leu Tyr Asp Asn Leu Tyr Pro Ser Arg Ile 
145                 150                 155                 160 
Ile Val Gly Asp Asp Ser Pro Ile Ala Leu Lys Phe Ala Asn Leu Leu 
                165                 170                 175     
Val Glu Gly Ser Lys Thr Pro Leu Ala Pro Val Leu Thr Met Gly Thr 
            180                 185                 190         
Arg Glu Ala Glu Ala Val Lys Leu Phe Ser Asn Thr Tyr Leu Ala Met 
        195                 200                 205             
Arg Val Ala Tyr Phe Asn Glu Leu Asp Thr Phe Ala Met Ser His Gly 
    210                 215                 220                 
Met Asn Ala Lys Glu Ile Ile Asp Gly Val Thr Leu Glu Pro Arg Ile 
225                 230                 235                 240 
Gly Gln Gly Tyr Ser Asn Pro Ser Phe Gly Tyr Gly Ala Tyr Cys Phe 
                245                 250                 255     
Pro Lys Asp Thr Lys Gln Leu Leu Ala Asn Phe Glu Gly Val Pro Gln 
            260                 265                 270         
Asp Ile Ile Gly Ala Ile Val Glu Ser Asn Glu Thr Arg Lys Glu Val 
        275                 280                 285             
Ile Val Ser Glu Val Glu Asn Arg Phe Pro Thr Thr Val Gly Val Tyr 
    290                 295                 300                 
Lys Leu Ala Ala Lys Ala Gly Ser Asp Asn Phe Arg Ser Ser Ala Ile 
305                 310                 315                 320 
Val Asp Ile Met Glu Arg Leu Ala Asn Lys Gly Tyr His Ile Lys Ile 
                325                 330                 335     
Phe Glu Pro Thr Val Glu Gln Phe Glu Asn Phe Glu Val Asp Asn Asn 
            340                 345                 350         
Leu Thr Thr Phe Ala Thr Glu Ser Asp Val Ile Ile Ala Asn Arg Val 
        355                 360                 365             
Pro Val Glu His Arg Ile Leu Phe Gly Lys Lys Leu Ile Thr Arg Asp 
    370                 375                 380                 
Val Tyr Gly Asp Asn 
385                 

<210> 41
<211> 401
<212> PRT
<213> Streptococcus


<220> 
<223> amino acid sequence of UDP-Glucose dehydrogenase (HASB)

<400> 41
Met Lys Ile Ser Val Ala Gly Ser Gly Tyr Val Gly Leu Ser Leu Ser 
1               5                   10                  15      
Ile Leu Leu Ala Gln His Asn Asp Val Thr Val Val Asp Ile Ile Asp 
            20                  25                  30          
Glu Lys Val Arg Leu Ile Asn Gln Gly Ile Ser Pro Ile Lys Asp Ala 
        35                  40                  45              
Asp Ile Glu Glu Tyr Leu Lys Asn Ala Pro Leu Asn Leu Thr Ala Thr 
    50                  55                  60                  
Leu Asp Gly Ala Ser Ala Tyr Ser Asn Ala Asp Leu Ile Ile Ile Ala 
65                  70                  75                  80  
Thr Pro Thr Asn Tyr Asp Ser Glu Arg Asn Tyr Phe Asp Thr Arg His 
                85                  90                  95      
Val Glu Glu Val Ile Glu Gln Val Leu Asp Leu Asn Ala Ser Ala Thr 
            100                 105                 110         
Ile Ile Ile Lys Ser Thr Ile Pro Leu Gly Phe Ile Lys His Val Arg 
        115                 120                 125             
Glu Lys Tyr Gln Thr Asp Arg Ile Ile Phe Ser Pro Glu Phe Leu Arg 
    130                 135                 140                 
Glu Ser Lys Ala Leu Tyr Asp Asn Leu Tyr Pro Ser Arg Ile Ile Val 
145                 150                 155                 160 
Ser Tyr Glu Lys Asp Asp Ser Pro Arg Val Ile Gln Ala Ala Lys Ala 
                165                 170                 175     
Phe Ala Gly Leu Leu Lys Glu Gly Ala Lys Ser Lys Asp Thr Pro Val 
            180                 185                 190         
Leu Phe Met Gly Ser Gln Glu Ala Glu Ala Val Lys Leu Phe Ala Asn 
        195                 200                 205             
Thr Phe Leu Ala Met Arg Val Ser Tyr Phe Asn Glu Leu Asp Thr Tyr 
    210                 215                 220                 
Ser Glu Ser Lys Gly Leu Asp Ala Gln Arg Val Ile Glu Gly Val Cys 
225                 230                 235                 240 
His Asp Gln Arg Ile Gly Asn His Tyr Asn Asn Pro Ser Phe Gly Tyr 
                245                 250                 255     
Gly Gly Tyr Cys Leu Pro Lys Asp Ser Lys Gln Leu Leu Ala Asn Tyr 
            260                 265                 270         
Arg Gly Ile Pro Gln Ser Leu Met Ser Ala Ile Val Glu Ser Asn Lys 
        275                 280                 285             
Ile Arg Lys Ser Tyr Leu Ala Glu Gln Ile Leu Asp Arg Ala Ser Ser 
    290                 295                 300                 
Gln Lys Gln Ala Gly Val Pro Leu Thr Ile Gly Phe Tyr Arg Leu Ile 
305                 310                 315                 320 
Met Lys Ser Asn Ser Asp Asn Phe Arg Glu Ser Ala Ile Lys Asp Ile 
                325                 330                 335     
Ile Asp Ile Ile Asn Asp Tyr Gly Val Asn Ile Val Ile Tyr Glu Pro 
            340                 345                 350         
Met Leu Gly Glu Asp Ile Gly Tyr Arg Val Val Lys Asp Leu Glu Gln 
        355                 360                 365             
Phe Lys Asn Glu Ser Thr Ile Ile Val Ser Asn Arg Phe Glu Asp Asp 
    370                 375                 380                 
Leu Gly Asp Val Ile Asp Lys Val Tyr Thr Arg Asp Val Phe Gly Arg 
385                 390                 395                 400 
Asp 
    

<210> 42
<211> 1026
<212> DNA
<213> Pseudomonas aeruginosa


<220> 
<223> nucleic acid sequence of UDP-glucose-4-epimerase (GNE1)

<400> 42
atgatgtccc gttacgagga acttcgtaaa gagctgcctg cacagccgaa ggtatggttg      60

atcactggtg tcgcgggctt catcgggtca aatctgctag agaccttgct taaattggat     120

cagaaggttg ttggcttgga caactttgca actggccacc agaggaatct ggacgaggtg     180

aggtcattgg tttctgagaa acagtggagc aactttaagt ttattcaagg ggacattaga     240

aatctggacg actgcaacaa cgcatgtgca ggcgtcgatt atgtcttaca ccaggcagca     300

ttgggcagtg tgccgaggtc tataaacgac cctataacat cgaatgcaac taacatagac     360

ggtttcttga acatgctgat tgcagcgagg gatgcaaaag ttcagtcttt tacctatgcc     420

gcttcatcct ctacatacgg ggatcacccc ggtttgccaa aggtggaaga cactatcggc     480

aagcctctat ctccatacgc tgtgacgaag tatgttaatg agttgtacgc agacgtgttt     540

tcacgttgtt atggattttc aaccatcggt ctgagatact ttaacgtctt cggccgtaga     600

caagatccga atggggcata cgccgccgta atccctaagt ggacatcctc aatgatacag     660

ggtgacgacg tctacattaa cggagatgga gagacatcac gtgacttctg ctacatagaa     720

aacacagttc aagcaaactt attagccgca acggccggcc tagacgccag aaaccaggtg     780

tataatatcg cggtgggtgg tagaacgtca ctaaatcagc ttttcttcgc cttgagagac     840

ggtctagctg agaacggcgt tagctaccat agggaaccag tttataggga ttttagagaa     900

ggagatgtga gacacagctt ggcagatatt tccaaggcgg ctaaacttct tgggtatgct     960

cctaaatatg acgtatcagc aggggtggcg cttgcaatgc catggtatat aatgtttctt    1020

aagtaa                                                               1026


<210> 43
<211> 1020
<212> DNA
<213> Pasteurella multocida


<220> 
<223> nucleic acid sequence of UDP-glucose-4-epimerase (KFOA)

<400> 43
atgaacattc tagtgaccgg cggtgctggc tatatcggct cccataccag tttatgctta      60

ctgaataaag gatataacgt ggtcatcatt gacaacctga tcaatagttc atgcgagtcg     120

atccgtagga tagaactgat agctaagaag aaggtcacct tctacgagct gaacattaat     180

aatgaaaagg aagtgaacca gatccttaag aaacacaaat tcgattgcat aatgcacttc     240

gcaggtgcca agtcggtggc cgagtcacta attaagccaa ttttctacta tgacaacaac     300

gtctctggaa ctttgcagct gattaattgt gctataaaga acgacgtcgc aaatttcatc     360

ttttcttcat cagcaactgt ttatggtgag tcaaagatta tgccagtgac agaggactgc     420

cacatcggcg gcacactaaa tccatacgga acatcaaaat acatttcaga gttgatgata     480

agggacatcg ccaagaagta ctcagacact aatttcttat gcttgcgtta tttcaatcct     540

accggggccc acgagtccgg catgatcggc gagtctccag ctgatatacc atccaatctg     600

gtgccttaca ttttacaggt ggccatgggc aagttggaga agttaatggt attcggcggt     660

gactacccaa caaaggacgg cacgggtgtg agagactata ttcacgtgat ggacctagcg     720

gaaggtcatg tggcagccct aagctacctt ttcagagata ataacactaa ttaccatgta     780

ttcaatctgg gcacgggtaa gggctacagt gtccttgaat tagtaagcac attcgagaaa     840

atctcgggtg tcaggattcc atacgagatc gtttctcgtc gtgatgggga catcgcagag     900

agttggtcat caccggagaa agcgaacaag tacttaaatt ggaaggccaa gagggagctt     960

gagacaatgc tagaagacgc atggcgttgg cagatgaaga acccgaatgg ttacatataa    1020


<210> 44
<211> 1021
<212> DNA
<213> Escherichia coli


<220> 
<223> nucleic acid sequence of UDP-glucose-4-epimerase (KFOA)

<400> 44
aatgaacatt ctagtgaccg gcggtgctgg ctatatcggc tcccatacca gtttatgctt      60

actgaataaa ggatataacg tggtcatcat tgacaacctg atcaatagtt catgcgagtc     120

gatccgtagg atagaactga tagctaagaa gaaggtcacc ttctacgagc tgaacattaa     180

taatgaaaag gaagtgaacc agatccttaa gaaacacaaa ttcgattgca taatgcactt     240

cgcaggtgcc aagtcggtgg ccgagtcact aattaagcca attttctact atgacaacaa     300

cgtctctgga actttgcagc tgattaattg tgctataaag aacgacgtcg caaatttcat     360

cttttcttca tcagcaactg tttatggtga gtcaaagatt atgccagtga cagaggactg     420

ccacatcggc ggcacactaa atccatacgg aacatcaaaa tacatttcag agttgatgat     480

aagggacatc gccaagaagt actcagacac taatttctta tgcttgcgtt atttcaatcc     540

taccggggcc cacgagtccg gcatgatcgg cgagtctcca gctgatatac catccaatct     600

ggtgccttac attttacagg tggccatggg caagttggag aagttaatgg tattcggcgg     660

tgactaccca acaaaggacg gcacgggtgt gagagactat attcacgtga tggacctagc     720

ggaaggtcat gtggcagccc taagctacct tttcagagat aataacacta attaccatgt     780

attcaatctg ggcacgggta agggctacag tgtccttgaa ttagtaagca cattcgagaa     840

aatctcgggt gtcaggattc catacgagat cgtttctcgt cgtgatgggg acatcgcaga     900

gagttggtca tcaccggaga aagcgaacaa gtacttaaat tggaaggcca agagggagct     960

tgagacaatg ctagaagacg catggcgttg gcagatgaag aacccgaatg gttacatata    1020

a                                                                    1021


<210> 45
<211> 341
<212> PRT
<213> Pseudomonas aeruginosa


<220> 
<223> amino acid sequence of UDP-glucose-4-epimerase (GNE1)

<400> 45
Met Met Ser Arg Tyr Glu Glu Leu Arg Lys Glu Leu Pro Ala Gln Pro 
1               5                   10                  15      
Lys Val Trp Leu Ile Thr Gly Val Ala Gly Phe Ile Gly Ser Asn Leu 
            20                  25                  30          
Leu Glu Thr Leu Leu Lys Leu Asp Gln Lys Val Val Gly Leu Asp Asn 
        35                  40                  45              
Phe Ala Thr Gly His Gln Arg Asn Leu Asp Glu Val Arg Ser Leu Val 
    50                  55                  60                  
Ser Glu Lys Gln Trp Ser Asn Phe Lys Phe Ile Gln Gly Asp Ile Arg 
65                  70                  75                  80  
Asn Leu Asp Asp Cys Asn Asn Ala Cys Ala Gly Val Asp Tyr Val Leu 
                85                  90                  95      
His Gln Ala Ala Leu Gly Ser Val Pro Arg Ser Ile Asn Asp Pro Ile 
            100                 105                 110         
Thr Ser Asn Ala Thr Asn Ile Asp Gly Phe Leu Asn Met Leu Ile Ala 
        115                 120                 125             
Ala Arg Asp Ala Lys Val Gln Ser Phe Thr Tyr Ala Ala Ser Ser Ser 
    130                 135                 140                 
Thr Tyr Gly Asp His Pro Gly Leu Pro Lys Val Glu Asp Thr Ile Gly 
145                 150                 155                 160 
Lys Pro Leu Ser Pro Tyr Ala Val Thr Lys Tyr Val Asn Glu Leu Tyr 
                165                 170                 175     
Ala Asp Val Phe Ser Arg Cys Tyr Gly Phe Ser Thr Ile Gly Leu Arg 
            180                 185                 190         
Tyr Phe Asn Val Phe Gly Arg Arg Gln Asp Pro Asn Gly Ala Tyr Ala 
        195                 200                 205             
Ala Val Ile Pro Lys Trp Thr Ser Ser Met Ile Gln Gly Asp Asp Val 
    210                 215                 220                 
Tyr Ile Asn Gly Asp Gly Glu Thr Ser Arg Asp Phe Cys Tyr Ile Glu 
225                 230                 235                 240 
Asn Thr Val Gln Ala Asn Leu Leu Ala Ala Thr Ala Gly Leu Asp Ala 
                245                 250                 255     
Arg Asn Gln Val Tyr Asn Ile Ala Val Gly Gly Arg Thr Ser Leu Asn 
            260                 265                 270         
Gln Leu Phe Phe Ala Leu Arg Asp Gly Leu Ala Glu Asn Gly Val Ser 
        275                 280                 285             
Tyr His Arg Glu Pro Val Tyr Arg Asp Phe Arg Glu Gly Asp Val Arg 
    290                 295                 300                 
His Ser Leu Ala Asp Ile Ser Lys Ala Ala Lys Leu Leu Gly Tyr Ala 
305                 310                 315                 320 
Pro Lys Tyr Asp Val Ser Ala Gly Val Ala Leu Ala Met Pro Trp Tyr 
                325                 330                 335     
Ile Met Phe Leu Lys 
            340     

<210> 46
<211> 338
<212> PRT
<213> Pasteurella multocida


<220> 
<223> amino acid sequence of UDP-glucose-4-epimerase (KFOA)

<400> 46
Met Ala Ile Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      
Val Val Glu Leu Leu Asn Ala Asn Lys Asp Val Val Val Leu Asp Asn 
            20                  25                  30          
Leu Cys Asn Ser Ser Pro Lys Ser Leu Glu Arg Val Ala Gln Ile Thr 
        35                  40                  45              
Gly Lys Gln Val Lys Phe Tyr Gln Gly Asp Ile Leu Asp Thr Ala Leu 
    50                  55                  60                  
Leu Gln Lys Ile Phe Ala Glu Asn Gln Ile Gln Ser Val Ile His Phe 
65                  70                  75                  80  
Ala Gly Leu Lys Ala Val Gly Glu Ser Val Gln Lys Pro Ala Glu Tyr 
                85                  90                  95      
Tyr Met Asn Asn Val Thr Gly Ser Leu Val Leu Ile Gln Glu Met Lys 
            100                 105                 110         
Lys Ala Gly Val Trp Asn Phe Val Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             
Gly Asp Pro Glu Ile Ile Pro Ile Thr Glu Ser Cys Lys Val Gly Gly 
    130                 135                 140                 
Thr Thr Asn Pro Tyr Gly Thr Ser Lys Phe Met Val Glu Gln Ile Leu 
145                 150                 155                 160 
Lys Asp Ile Ala Lys Ala Thr Pro Glu Phe Ser Ile Thr Ile Leu Arg 
                165                 170                 175     
Tyr Phe Asn Pro Val Gly Ala His Glu Ser Gly Leu Ile Gly Glu Asp 
            180                 185                 190         
Pro Asn Gly Ile Pro Asn Asn Leu Leu Pro Tyr Ile Ser Gln Val Ala 
        195                 200                 205             
Ile Gly Lys Leu Pro Gln Leu Ser Val Phe Gly Ser Asp Tyr Glu Thr 
    210                 215                 220                 
His Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Val Asp Leu Ala 
225                 230                 235                 240 
Ile Gly His Leu Lys Ala Leu Asp Arg His Glu Gly Asp Ala Gly Leu 
                245                 250                 255     
His Ile Tyr Asn Leu Gly Thr Gly Ser Gly Tyr Ser Val Leu Asp Met 
            260                 265                 270         
Val Lys Ala Phe Glu Lys Val Asn Asp Ile Lys Ile Pro Tyr Lys Leu 
        275                 280                 285             
Val Asp Arg Arg Pro Gly Asp Ile Ala Thr Cys Tyr Ser Asp Pro Ser 
    290                 295                 300                 
Leu Ala Lys Thr Glu Leu Asn Trp Thr Ala Ala Arg Gly Leu Glu Gln 
305                 310                 315                 320 
Met Met Lys Asp Thr Trp His Trp Gln Lys Lys Asn Pro Lys Gly Tyr 
                325                 330                 335     
Arg Asp 
        

<210> 47
<211> 339
<212> PRT
<213> Escherichia coli


<220> 
<223> amino acid sequence of UDP-glucose-4-epimerase (KFOA)

<400> 47
Met Asn Ile Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      
Ser Leu Cys Leu Leu Asn Lys Gly Tyr Asn Val Val Ile Ile Asp Asn 
            20                  25                  30          
Leu Ile Asn Ser Ser Cys Glu Ser Ile Arg Arg Ile Glu Leu Ile Ala 
        35                  40                  45              
Lys Lys Lys Val Thr Phe Tyr Glu Leu Asn Ile Asn Asn Glu Lys Glu 
    50                  55                  60                  
Val Asn Gln Ile Leu Lys Lys His Lys Phe Asp Cys Ile Met His Phe 
65                  70                  75                  80  
Ala Gly Ala Lys Ser Val Ala Glu Ser Leu Ile Lys Pro Ile Phe Tyr 
                85                  90                  95      
Tyr Asp Asn Asn Val Ser Gly Thr Leu Gln Leu Ile Asn Cys Ala Ile 
            100                 105                 110         
Lys Asn Asp Val Ala Asn Phe Ile Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             
Gly Glu Ser Lys Ile Met Pro Val Thr Glu Asp Cys His Ile Gly Gly 
    130                 135                 140                 
Thr Leu Asn Pro Tyr Gly Thr Ser Lys Tyr Ile Ser Glu Leu Met Ile 
145                 150                 155                 160 
Arg Asp Ile Ala Lys Lys Tyr Ser Asp Thr Asn Phe Leu Cys Leu Arg 
                165                 170                 175     
Tyr Phe Asn Pro Thr Gly Ala His Glu Ser Gly Met Ile Gly Glu Ser 
            180                 185                 190         
Pro Ala Asp Ile Pro Ser Asn Leu Val Pro Tyr Ile Leu Gln Val Ala 
        195                 200                 205             
Met Gly Lys Leu Glu Lys Leu Met Val Phe Gly Gly Asp Tyr Pro Thr 
    210                 215                 220                 
Lys Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Met Asp Leu Ala 
225                 230                 235                 240 
Glu Gly His Val Ala Ala Leu Ser Tyr Leu Phe Arg Asp Asn Asn Thr 
                245                 250                 255     
Asn Tyr His Val Phe Asn Leu Gly Thr Gly Lys Gly Tyr Ser Val Leu 
            260                 265                 270         
Glu Leu Val Ser Thr Phe Glu Lys Ile Ser Gly Val Arg Ile Pro Tyr 
        275                 280                 285             
Glu Ile Val Ser Arg Arg Asp Gly Asp Ile Ala Glu Ser Trp Ser Ser 
    290                 295                 300                 
Pro Glu Lys Ala Asn Lys Tyr Leu Asn Trp Lys Ala Lys Arg Glu Leu 
305                 310                 315                 320 
Glu Thr Met Leu Glu Asp Ala Trp Arg Trp Gln Met Lys Asn Pro Asn 
                325                 330                 335     
Gly Tyr Ile 
            

<210> 48
<211> 1197
<212> DNA
<213> Cupiennius salei


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Cupiennius salei with a N-terminal secretion
      signal

<400> 48
atgcaattca gcactgttgc atcagttgca tttgtcgccc tggcgaattt tgtagccgcg      60

ttcaagattt actggaacgt cccaactttt cagtgcacgc ataactacaa aatcgattat     120

gtcaaattgt tgtccactta cgggatacag gtcaatgatg gcggtaagtt tcaaggaaac     180

caagtgacta tcttttatga aacccagttg ggtttgtatc cacgaatcct aaaatctggt     240

aaaatggaaa acggcggaat ccctcaacgc ggtaactttg agaaacacct agaaaaggca     300

agcacggacc tccagaaagt gatcccttgg aaagagttta gcggattagg tgtgatagat     360

tgggaggctt ggagacccac atgggaattt aactgggaac cgttgaggat atatcaaacc     420

gaatcaatta agagagctaa agaactacac cctaccgcaa acgattccgc agtaaaagaa     480

attgcagagc ggcaatggga agattcagcc aagttataca tgttagaaac actgcggctg     540

gcaaagaaac ttcgacctca agcgccttgg tgttactact tatttcctga ttgctataat     600

tacgtcggaa agaaaccaaa agatttccaa tgtagtgcct cgatacgtaa aggtaacgat     660

aagctaagct ggttgtggaa agattctacg gcattgtgtc catcgatata cgtatatgaa     720

tcacaattag acaggtattc ttttgaacaa aggacatggc gcgacaatga gaaacttcgg     780

gaagcgttgc gtgtagccac gagaacctct aaaatatacc catacgttaa ctatttcgat     840

aaggagctta taccggagca agaagtatgg agaatgcttg cgcaggcagc tgctgtcggt     900

ggcagtggtg cggtaatttg gggctcatct gctgcagttg catctgaaga gttatgtaaa     960

tctttaaaac agtatattat tgaaacgctt gggccggcgg cagagaaggt ggcttggcgt    1020

agtgacttat gcagcaaaga aatttgtaat aatcagggtc gctgcacatt cccggacgat    1080

gattatgcaa acgcatggaa attatttaca gatgatactg ttaagtttta tgctggtaat    1140

attacatgta ggtgctccga gaattattct ggtcgtttct gcgaaaagaa gaattaa       1197


<210> 49
<211> 1218
<212> DNA
<213> Tityus serrulatus


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Tityus serrulatus with a N-terminal secretion
      signal

<400> 49
atgcaattct ctactgtcgc ttccgttgct ttcgtcgctt tggctaactt tgttgccgct      60

gctgatttta aagtttactg ggaagtgcct tccttccttt gttctaaacg ttttaaaatt     120

aatgtaacgg aagttttaac aagtcacgag attcttgtca atcagggtga gagtttcaac     180

ggtgacaaga tagtaatctt ttacgaaaac caattgggga agtacccgca tattgactca     240

aacaatgtgg agatcaatgg aggaatactt caagtagccg atttggcgaa gcatttgaaa     300

gtagccaagg ataatatcac taaattcgtc ccgaatccta atttcaacgg tgtcggagtg     360

atcgactggg aagcttggcg gccatcatgg gaatttaact ggggtaagtt aaaagtatat     420

aaagaaaaga gcattgactt ggtcaagtcg aaacatccgg agtggccctc cgacagggtt     480

gaaaaggttg ctaaagagga gtgggaggag agtgccaaag aatggatggt gaagaccctg     540

aagttagcac aggaaatgcg accgaacgca gtttggtgct attatctatt ccctgactgc     600

tacaattatt tcggtaagga tcaaccctct caattcagct gctcgtctcg aattcagaag     660

gaaaattctc gtctttcttg gctctggaat caatcaacag ccatttgcct aagcatttat     720

atccaggaat cccatgttac caaatataat atgtcccagc ggacatggtg gatcgatgcg     780

agattaagag aagcaattcg agtcagcgaa cacagaccaa acatacccat ctacccttac     840

attaattata ttctacctgg aactaatcaa actgtaccag caatggactt taaaaggaca     900

ctgggtcaaa tagctagcct cggcctagat ggtgctttgt tatggggatc tagctatcat     960

gttttaacag aatctcaatg caaaatcact tctgattatg tgaaatcagt gattgctcct    1020

accgtggcta ctgtcgttct caatacaaac agatgctcac agataatttg taagggtcgc    1080

ggcaactgtg tttggcctga agaaccattt agttcttgga aatacttagt tgaccccaaa    1140

atgccagtgt tcaagccaac caacatccac tgtaaatgta aaggttacct aggtagatac    1200

tgtgagatcc caaagtaa                                                  1218


<210> 50
<211> 1308
<212> DNA
<213> Bos taurus


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Bos Taurus with a N-terminal secretion signal

<400> 50
atgcaatttt ctactgttgc ttctgtcgct ttcgtagcac tggccaattt tgtagctgct      60

ggaagccgtg accccgttgt cccaaaccag cctttcacaa caatatggaa cgcaaatacg     120

gagtggtgca tgaagaagca tggagtggac gtcgatattt caatcttcga cgtggtcact     180

aatccaggac agacatttag aggtccaaat atgacaatat tttacagttc acaattgggg     240

acctaccctt actacacatc cgcgggtgag ccagtattcg gtggtctacc ccagaacgca     300

agtttgaatg cccacttggc taggacattt caagatattc tggcagccat gccagagccc     360

aggttctcag gtttggctgt catagactgg gaagcgtgga gacctcgttg ggcatttaat     420

tgggatacga aagacatata caggcagagg tccagagcat tggttcagaa acagcacccg     480

gattggctgg cgccacgtgt tgaggccgca gcgcaagacc agttcgaggg cgctgctgag     540

gagtggatgg ccggcacact taaattaggg caggcgcttc gtcctcaagg cttgtggggt     600

ttctataact tcccggagtg ttacaattat gacttcaaat ctccgaacta cacaggaagg     660

tgccctttaa acatctgtgc gcagaacgac cagttaggtt ggctatgggg tcaaagtcgt     720

gcactatatc catcaatcta cttgccggcg gctttggaag gcacgaagaa gactcagatg     780

ttcgttcagc accgtgtagc agaggcattt agggtggcgg caggcgctgg tgaccccaag     840

ctacccgtct taccctatat gcagctattt tacgatatga caaaccactt cttgcccgcg     900

gaagaactgg aacatagctt aggtgagtca gcagcgcagg gtgcagccgg ggttgttctg     960

tgggtttcct ggttatcaac ttcgacaaag gaaagctgtc aagcaatcaa ggaatacgta    1020

gatactacgt tgggcccttc aatcttgaac gtcacatctg gtgccaggtt gtgttctcag    1080

gtattgtgca gtggccacgg gagatgcgcg agaagacctt catatcctaa agccaggctg    1140

attctaaatt caacgtcgtt ctccatcaag ccaacacccg gtggtggtcc attgacactt    1200

caaggcgctt tgagtttgga agacagatta cgtatggcag ttgagtttga atgcagatgt    1260

tacagaggat ggagagggac acgttgtgag cagtggggca tgtggtaa                 1308


<210> 51
<211> 1137
<212> DNA
<213> Apis mellifera


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Apis mellifera with a N-terminal secretion
      signal

<400> 51
atgcagtttt ccacagttgc ttccgtagct ttcgtagctt tagcaaattt tgtcgcagct      60

ttgttgttgg gcttcgttca gtctactcca gataataata agactgtgcg tgaatttaac     120

gtgtattgga acgttcctac attcatgtgc cataagtacg ggttgagatt cgaagaggtg     180

agcgagaagt atggcatttt gcaaaattgg atggacaaat tcagaggaga ggaaattgcg     240

atcttatacg accccggcat gttccccgca ctgttgaaag accccaatgg gaatgtagta     300

gctaggaatg gcggagtgcc ccagcttggc aatttaacta aacatttaca ggtgttcagg     360

gaccacctaa tcaatcagat tccagataaa agctttcccg gagttggtgt aatagatttc     420

gagtcatgga gacctatttt cagacagaac tgggcctctt tgcaaccgta caagaagcta     480

tcagtcgaag tcgtacgtcg tgagcaccca ttctgggatg atcagagagt ggagcaagag     540

gcgaaaagaa gatttgaaaa gtacggccag cttttcatgg aagagacctt gaaagccgca     600

aaacgtatgc gtcctgcagc caattggggc tactacgctt acccttattg ctacaacctg     660

accccaaacc agccctcagc tcaatgcgag gctacaacaa tgcaggagaa cgacaagatg     720

tcatggttat tcgagtccga ggacgtctta ctgcccagcg tctatttgag gtggaacctg     780

actagcggag agagggttgg tttagttggt ggtcgtgtca aggaagccct gagaatagct     840

cgtcagatga ccacctctag gaagaaggtc ctaccatact actggtacaa ataccaggat     900

aggagagaca cggacctaag tagggctgat cttgaggcga ctctacgtaa aatcacggac     960

ttaggagccg acggtttcat aatctgggga tcttccgatg acatcaacac caaggcaaaa    1020

tgtttgcagt tcagagaata tttgaataac gagttgggcc cggcagtgaa gagaatagcc    1080

ttaaacaata atgcgaatga caggctaaca gtggatgtgt ctgttgacca ggtttaa       1137


<210> 52
<211> 1305
<212> DNA
<213> Macaca mulatta


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Macaca mulatta with a N-terminal secretion
      signal

<400> 52
atgcaattca gtactgtcgc tagcgtcgcc tttgtggctc ttgcaaattt cgtcgctgct      60

tcacgtgggc ctttattgcc gaacagacca tttgcaacgg tatggaatgc taacacccaa     120

tggtgtttag agaggcactc agtagacgtc gatgtctcca tatttgatgt tgtagcaaac     180

cccggccaga cttttcgtgg gccggacatg actattttct attccagtca gctaggtact     240

tacccttatt ataccccgac gggtgaacct gtctttggtg gccttccaca gaacgcatca     300

cttatagcgc acttggctag gactttccag gatatattgg cagctatacc agcccccgac     360

ttttctgggc tagccgtaat tgactgggaa gcatggagac cgagatgggc atttaactgg     420

gacacgaaag acatttacag gcaaaggtcc cgtgccttag tccaagcaca gcatcccgac     480

tggccagtta ctcaagttga ggctgtggca caagaccagt tccagggtgc tgcgagggca     540

tggatggcag gaaccttgca attaggccgt gctttaagac caaggggact atggggcttc     600

tacggttttc ccgattgcta caattacgat ttcctatctc ctaattacac agggcaatgc     660

ccatcaggga tcagagcaca aaatgaccag ttaggatggt tgtggggtca gagtcgtgca     720

ttatatccca gtatctacat gccggctgtt ttggaaggaa caggcaaatc ccaaatgtac     780

gtgcagcaca gggtcgcgga agcctttagg gttgctgttg cagcaggcga cccaaactta     840

cccgtcctac cgtacgtcca gattttctac gatatgacca accactttct tccattggac     900

gagttagagc atagtcttgg agaatcagcg gctcagggcg cagcaggagt cgtgttatgg     960

gtgtcatggg agaatactag aacaaaagaa tcttgccagg caattaaaga atatatggac    1020

actaccttgg ggccttttat tctgaacgtc acttcgggtg cgttgttatg ctcgcaagcc    1080

ttatgttcaa gccatggtcg ttgtgtccgt cgtccctcac atccaaaagc cttgctaatc    1140

cttaatcccg caagctttag tattcagttg acaccagatg gtggtccctt gtcgttaagg    1200

ggagcattgt cacttgagga ccaggcacaa atggctgttg aattcaaatg caggtgctac    1260

cccgggtggc aaggcccttg gtgtgagcag aagagtatgt ggtaa                    1305


<210> 53
<211> 1083
<212> DNA
<213> Vespa magnifica


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Vespa magnifica with a N-terminal secretion
      signal

<400> 53
atgcaatttt ctacagtggc aagtgttgca ttcgttgcac tagccaactt tgtggcggca      60

gatagctgtg ggtcaaactg cgaaaagagt gagagaccga aaagggtctt caacatttac     120

tggaacgtac ctacattcat gtgtcaccag tacggactat actttgacga ggtcacgaat     180

tttaatataa agcacaacag caaagacaat tttcaagggg acaagatcgc gatcttttat     240

gaccccgggg agtttcccgc tctgctgcca ctaaactatg gtaagtacaa gatcaggaat     300

ggtggtgttc cacaagaggg taacatcacc atccatctgc agagattcat agagtaccta     360

gataagacct atccgaaccg taacttttca ggcatcggtg tgatcgattt cgagaggtgg     420

agaccaattt tcagacagaa ttggggtaat atgaagattt acaagaactt ctccatcgat     480

cttgtgcgta aagagcatcc tttctggaat aagaaaatga tcgagttgga agcttctaaa     540

agattcgaga aatacgcccg tctgttcatg gaagaaacat taaagttggc taagaaaact     600

agaaaacagg ccgattgggg ctactacggt tacccctatt gcttcaacat gtctcctact     660

aatttcgttc ctgactgcga tgtcacagct agggatgaga acaacgagat gtcttggttg     720

tttaacaacc agaatgtcct attaccaagt gtatacatta ggagagagct aactcctgac     780

cagaggattg ggcttgtaca ggggagagtg aaggaagctg tgagaatttc aaataaactg     840

aagcactcac ctaaagtctt cagctattgg tggtatgttt accaagacga gaccaacacc     900

ttcttaacgg agaccgacgt caagaagacg tttcaggaga ttgtgatcaa cggtggagat     960

gggattataa tctggggttc gtcctctgat gtaaacagct tgtccaagtg tacgaggtta    1020

agggagtacc tattgacagt cttgggacca attgctgtta acgtgactga agcagtaaac    1080

taa                                                                  1083


<210> 54
<211> 1407
<212> DNA
<213> Cupiennius salei


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Cupiennius salei with a N-terminal secretion
      signal and a C-terminal anchoring signal

<400> 54
atgcaattca gcactgttgc atcagttgca tttgtcgccc tggcgaattt tgtagccgcg      60

ttcaagattt actggaacgt cccaactttt cagtgcacgc ataactacaa aatcgattat     120

gtcaaattgt tgtccactta cgggatacag gtcaatgatg gcggtaagtt tcaaggaaac     180

caagtgacta tcttttatga aacccagttg ggtttgtatc cacgaatcct aaaatctggt     240

aaaatggaaa acggcggaat ccctcaacgc ggtaactttg agaaacacct agaaaaggca     300

agcacggacc tccagaaagt gatcccttgg aaagagttta gcggattagg tgtgatagat     360

tgggaggctt ggagacccac atgggaattt aactgggaac cgttgaggat atatcaaacc     420

gaatcaatta agagagctaa agaactacac cctaccgcaa acgattccgc agtaaaagaa     480

attgcagagc ggcaatggga agattcagcc aagttataca tgttagaaac actgcggctg     540

gcaaagaaac ttcgacctca agcgccttgg tgttactact tatttcctga ttgctataat     600

tacgtcggaa agaaaccaaa agatttccaa tgtagtgcct cgatacgtaa aggtaacgat     660

aagctaagct ggttgtggaa agattctacg gcattgtgtc catcgatata cgtatatgaa     720

tcacaattag acaggtattc ttttgaacaa aggacatggc gcgacaatga gaaacttcgg     780

gaagcgttgc gtgtagccac gagaacctct aaaatatacc catacgttaa ctatttcgat     840

aaggagctta taccggagca agaagtatgg agaatgcttg cgcaggcagc tgctgtcggt     900

ggcagtggtg cggtaatttg gggctcatct gctgcagttg catctgaaga gttatgtaaa     960

tctttaaaac agtatattat tgaaacgctt gggccggcgg cagagaaggt ggcttggcgt    1020

agtgacttat gcagcaaaga aatttgtaat aatcagggtc gctgcacatt cccggacgat    1080

gattatgcaa acgcatggaa attatttaca gatgatactg ttaagtttta tgctggtaat    1140

attacatgta ggtgctccga gaattattct ggtcgtttct gcgaaaagaa gaatggatcc    1200

gccatttctc aaatcactga cggtcaaatc caagctacta ccactgctac caccgaagct    1260

accaccactg ctgccccatc ttccaccgtt gaaactgttt ctccatccag caccgaaact    1320

atctctcaac aaactgaaaa tggtgctgct aaggccgctg tcggtatggg tgccggtgct    1380

ctagctgctg ctgctatgtt gttataa                                        1407


<210> 55
<211> 1428
<212> DNA
<213> Tityus serrulatus


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Tityus serrulatus with a N-terminal secretion
      signal and a C-terminal anchoring signal

<400> 55
atgcaattct ctactgtcgc ttccgttgct ttcgtcgctt tggctaactt tgttgccgct      60

gctgatttta aagtttactg ggaagtgcct tccttccttt gttctaaacg ttttaaaatt     120

aatgtaacgg aagttttaac aagtcacgag attcttgtca atcagggtga gagtttcaac     180

ggtgacaaga tagtaatctt ttacgaaaac caattgggga agtacccgca tattgactca     240

aacaatgtgg agatcaatgg aggaatactt caagtagccg atttggcgaa gcatttgaaa     300

gtagccaagg ataatatcac taaattcgtc ccgaatccta atttcaacgg tgtcggagtg     360

atcgactggg aagcttggcg gccatcatgg gaatttaact ggggtaagtt aaaagtatat     420

aaagaaaaga gcattgactt ggtcaagtcg aaacatccgg agtggccctc cgacagggtt     480

gaaaaggttg ctaaagagga gtgggaggag agtgccaaag aatggatggt gaagaccctg     540

aagttagcac aggaaatgcg accgaacgca gtttggtgct attatctatt ccctgactgc     600

tacaattatt tcggtaagga tcaaccctct caattcagct gctcgtctcg aattcagaag     660

gaaaattctc gtctttcttg gctctggaat caatcaacag ccatttgcct aagcatttat     720

atccaggaat cccatgttac caaatataat atgtcccagc ggacatggtg gatcgatgcg     780

agattaagag aagcaattcg agtcagcgaa cacagaccaa acatacccat ctacccttac     840

attaattata ttctacctgg aactaatcaa actgtaccag caatggactt taaaaggaca     900

ctgggtcaaa tagctagcct cggcctagat ggtgctttgt tatggggatc tagctatcat     960

gttttaacag aatctcaatg caaaatcact tctgattatg tgaaatcagt gattgctcct    1020

accgtggcta ctgtcgttct caatacaaac agatgctcac agataatttg taagggtcgc    1080

ggcaactgtg tttggcctga agaaccattt agttcttgga aatacttagt tgaccccaaa    1140

atgccagtgt tcaagccaac caacatccac tgtaaatgta aaggttacct aggtagatac    1200

tgtgagatcc caaagggatc cgccatttct caaatcactg acggtcaaat ccaagctact    1260

accactgcta ccaccgaagc taccaccact gctgccccat cttccaccgt tgaaactgtt    1320

tctccatcca gcaccgaaac tatctctcaa caaactgaaa atggtgctgc taaggccgct    1380

gtcggtatgg gtgccggtgc tctagctgct gctgctatgt tgttataa                 1428


<210> 56
<211> 1518
<212> DNA
<213> Bos taurus


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Bos taurus with a N-terminal secretion signal
      and a C-terminal anchoring signal

<400> 56
atgcaatttt ctactgttgc ttctgtcgct ttcgtagcac tggccaattt tgtagctgct      60

ggaagccgtg accccgttgt cccaaaccag cctttcacaa caatatggaa cgcaaatacg     120

gagtggtgca tgaagaagca tggagtggac gtcgatattt caatcttcga cgtggtcact     180

aatccaggac agacatttag aggtccaaat atgacaatat tttacagttc acaattgggg     240

acctaccctt actacacatc cgcgggtgag ccagtattcg gtggtctacc ccagaacgca     300

agtttgaatg cccacttggc taggacattt caagatattc tggcagccat gccagagccc     360

aggttctcag gtttggctgt catagactgg gaagcgtgga gacctcgttg ggcatttaat     420

tgggatacga aagacatata caggcagagg tccagagcat tggttcagaa acagcacccg     480

gattggctgg cgccacgtgt tgaggccgca gcgcaagacc agttcgaggg cgctgctgag     540

gagtggatgg ccggcacact taaattaggg caggcgcttc gtcctcaagg cttgtggggt     600

ttctataact tcccggagtg ttacaattat gacttcaaat ctccgaacta cacaggaagg     660

tgccctttaa acatctgtgc gcagaacgac cagttaggtt ggctatgggg tcaaagtcgt     720

gcactatatc catcaatcta cttgccggcg gctttggaag gcacgaagaa gactcagatg     780

ttcgttcagc accgtgtagc agaggcattt agggtggcgg caggcgctgg tgaccccaag     840

ctacccgtct taccctatat gcagctattt tacgatatga caaaccactt cttgcccgcg     900

gaagaactgg aacatagctt aggtgagtca gcagcgcagg gtgcagccgg ggttgttctg     960

tgggtttcct ggttatcaac ttcgacaaag gaaagctgtc aagcaatcaa ggaatacgta    1020

gatactacgt tgggcccttc aatcttgaac gtcacatctg gtgccaggtt gtgttctcag    1080

gtattgtgca gtggccacgg gagatgcgcg agaagacctt catatcctaa agccaggctg    1140

attctaaatt caacgtcgtt ctccatcaag ccaacacccg gtggtggtcc attgacactt    1200

caaggcgctt tgagtttgga agacagatta cgtatggcag ttgagtttga atgcagatgt    1260

tacagaggat ggagagggac acgttgtgag cagtggggca tgtggggatc cgccatttct    1320

caaatcactg acggtcaaat ccaagctact accactgcta ccaccgaagc taccaccact    1380

gctgccccat cttccaccgt tgaaactgtt tctccatcca gcaccgaaac tatctctcaa    1440

caaactgaaa atggtgctgc taaggccgct gtcggtatgg gtgccggtgc tctagctgct    1500

gctgctatgt tgttataa                                                  1518


<210> 57
<211> 1347
<212> DNA
<213> Apis mellifera


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Apis mellifera with a N-terminal secretion
      signal and a C-terminal anchoring signal

<400> 57
atgcagtttt ccacagttgc ttccgtagct ttcgtagctt tagcaaattt tgtcgcagct      60

ttgttgttgg gcttcgttca gtctactcca gataataata agactgtgcg tgaatttaac     120

gtgtattgga acgttcctac attcatgtgc cataagtacg ggttgagatt cgaagaggtg     180

agcgagaagt atggcatttt gcaaaattgg atggacaaat tcagaggaga ggaaattgcg     240

atcttatacg accccggcat gttccccgca ctgttgaaag accccaatgg gaatgtagta     300

gctaggaatg gcggagtgcc ccagcttggc aatttaacta aacatttaca ggtgttcagg     360

gaccacctaa tcaatcagat tccagataaa agctttcccg gagttggtgt aatagatttc     420

gagtcatgga gacctatttt cagacagaac tgggcctctt tgcaaccgta caagaagcta     480

tcagtcgaag tcgtacgtcg tgagcaccca ttctgggatg atcagagagt ggagcaagag     540

gcgaaaagaa gatttgaaaa gtacggccag cttttcatgg aagagacctt gaaagccgca     600

aaacgtatgc gtcctgcagc caattggggc tactacgctt acccttattg ctacaacctg     660

accccaaacc agccctcagc tcaatgcgag gctacaacaa tgcaggagaa cgacaagatg     720

tcatggttat tcgagtccga ggacgtctta ctgcccagcg tctatttgag gtggaacctg     780

actagcggag agagggttgg tttagttggt ggtcgtgtca aggaagccct gagaatagct     840

cgtcagatga ccacctctag gaagaaggtc ctaccatact actggtacaa ataccaggat     900

aggagagaca cggacctaag tagggctgat cttgaggcga ctctacgtaa aatcacggac     960

ttaggagccg acggtttcat aatctgggga tcttccgatg acatcaacac caaggcaaaa    1020

tgtttgcagt tcagagaata tttgaataac gagttgggcc cggcagtgaa gagaatagcc    1080

ttaaacaata atgcgaatga caggctaaca gtggatgtgt ctgttgacca ggttggatcc    1140

gccatttctc aaatcactga cggtcaaatc caagctacta ccactgctac caccgaagct    1200

accaccactg ctgccccatc ttccaccgtt gaaactgttt ctccatccag caccgaaact    1260

atctctcaac aaactgaaaa tggtgctgct aaggccgctg tcggtatggg tgccggtgct    1320

ctagctgctg ctgctatgtt gttataa                                        1347


<210> 58
<211> 1515
<212> DNA
<213> Macaca mulatta


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Macaca mulatta with a N-terminal secretion
      signal and a C-terminal anchoring signal

<400> 58
atgcaattca gtactgtcgc tagcgtcgcc tttgtggctc ttgcaaattt cgtcgctgct      60

tcacgtgggc ctttattgcc gaacagacca tttgcaacgg tatggaatgc taacacccaa     120

tggtgtttag agaggcactc agtagacgtc gatgtctcca tatttgatgt tgtagcaaac     180

cccggccaga cttttcgtgg gccggacatg actattttct attccagtca gctaggtact     240

tacccttatt ataccccgac gggtgaacct gtctttggtg gccttccaca gaacgcatca     300

cttatagcgc acttggctag gactttccag gatatattgg cagctatacc agcccccgac     360

ttttctgggc tagccgtaat tgactgggaa gcatggagac cgagatgggc atttaactgg     420

gacacgaaag acatttacag gcaaaggtcc cgtgccttag tccaagcaca gcatcccgac     480

tggccagtta ctcaagttga ggctgtggca caagaccagt tccagggtgc tgcgagggca     540

tggatggcag gaaccttgca attaggccgt gctttaagac caaggggact atggggcttc     600

tacggttttc ccgattgcta caattacgat ttcctatctc ctaattacac agggcaatgc     660

ccatcaggga tcagagcaca aaatgaccag ttaggatggt tgtggggtca gagtcgtgca     720

ttatatccca gtatctacat gccggctgtt ttggaaggaa caggcaaatc ccaaatgtac     780

gtgcagcaca gggtcgcgga agcctttagg gttgctgttg cagcaggcga cccaaactta     840

cccgtcctac cgtacgtcca gattttctac gatatgacca accactttct tccattggac     900

gagttagagc atagtcttgg agaatcagcg gctcagggcg cagcaggagt cgtgttatgg     960

gtgtcatggg agaatactag aacaaaagaa tcttgccagg caattaaaga atatatggac    1020

actaccttgg ggccttttat tctgaacgtc acttcgggtg cgttgttatg ctcgcaagcc    1080

ttatgttcaa gccatggtcg ttgtgtccgt cgtccctcac atccaaaagc cttgctaatc    1140

cttaatcccg caagctttag tattcagttg acaccagatg gtggtccctt gtcgttaagg    1200

ggagcattgt cacttgagga ccaggcacaa atggctgttg aattcaaatg caggtgctac    1260

cccgggtggc aaggcccttg gtgtgagcag aagagtatgt ggggatccgc catttctcaa    1320

atcactgacg gtcaaatcca agctactacc actgctacca ccgaagctac caccactgct    1380

gccccatctt ccaccgttga aactgtttct ccatccagca ccgaaactat ctctcaacaa    1440

actgaaaatg gtgctgctaa ggccgctgtc ggtatgggtg ccggtgctct agctgctgct    1500

gctatgttgt tataa                                                     1515


<210> 59
<211> 1293
<212> DNA
<213> Vespa magnifica


<220> 
<223> reencoded nucleic acid sequence of hyaluronidase (HYAL)
      originating from Vespa magnifica with a N-terminal secretion
      signal and a C-terminal anchoring signal

<400> 59
atgcaatttt ctacagtggc aagtgttgca ttcgttgcac tagccaactt tgtggcggca      60

gatagctgtg ggtcaaactg cgaaaagagt gagagaccga aaagggtctt caacatttac     120

tggaacgtac ctacattcat gtgtcaccag tacggactat actttgacga ggtcacgaat     180

tttaatataa agcacaacag caaagacaat tttcaagggg acaagatcgc gatcttttat     240

gaccccgggg agtttcccgc tctgctgcca ctaaactatg gtaagtacaa gatcaggaat     300

ggtggtgttc cacaagaggg taacatcacc atccatctgc agagattcat agagtaccta     360

gataagacct atccgaaccg taacttttca ggcatcggtg tgatcgattt cgagaggtgg     420

agaccaattt tcagacagaa ttggggtaat atgaagattt acaagaactt ctccatcgat     480

cttgtgcgta aagagcatcc tttctggaat aagaaaatga tcgagttgga agcttctaaa     540

agattcgaga aatacgcccg tctgttcatg gaagaaacat taaagttggc taagaaaact     600

agaaaacagg ccgattgggg ctactacggt tacccctatt gcttcaacat gtctcctact     660

aatttcgttc ctgactgcga tgtcacagct agggatgaga acaacgagat gtcttggttg     720

tttaacaacc agaatgtcct attaccaagt gtatacatta ggagagagct aactcctgac     780

cagaggattg ggcttgtaca ggggagagtg aaggaagctg tgagaatttc aaataaactg     840

aagcactcac ctaaagtctt cagctattgg tggtatgttt accaagacga gaccaacacc     900

ttcttaacgg agaccgacgt caagaagacg tttcaggaga ttgtgatcaa cggtggagat     960

gggattataa tctggggttc gtcctctgat gtaaacagct tgtccaagtg tacgaggtta    1020

agggagtacc tattgacagt cttgggacca attgctgtta acgtgactga agcagtaaac    1080

ggatccgcca tttctcaaat cactgacggt caaatccaag ctactaccac tgctaccacc    1140

gaagctacca ccactgctgc cccatcttcc accgttgaaa ctgtttctcc atccagcacc    1200

gaaactatct ctcaacaaac tgaaaatggt gctgctaagg ccgctgtcgg tatgggtgcc    1260

ggtgctctag ctgctgctgc tatgttgtta taa                                 1293


<210> 60
<211> 398
<212> PRT
<213> Cupiennius salei


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Cupiennius salei with a N-terminal secretion signal

<400> 60
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Phe Lys Ile Tyr Trp Asn Val Pro Thr Phe Gln Cys 
            20                  25                  30          
Thr His Asn Tyr Lys Ile Asp Tyr Val Lys Leu Leu Ser Thr Tyr Gly 
        35                  40                  45              
Ile Gln Val Asn Asp Gly Gly Lys Phe Gln Gly Asn Gln Val Thr Ile 
    50                  55                  60                  
Phe Tyr Glu Thr Gln Leu Gly Leu Tyr Pro Arg Ile Leu Lys Ser Gly 
65                  70                  75                  80  
Lys Met Glu Asn Gly Gly Ile Pro Gln Arg Gly Asn Phe Glu Lys His 
                85                  90                  95      
Leu Glu Lys Ala Ser Thr Asp Leu Gln Lys Val Ile Pro Trp Lys Glu 
            100                 105                 110         
Phe Ser Gly Leu Gly Val Ile Asp Trp Glu Ala Trp Arg Pro Thr Trp 
        115                 120                 125             
Glu Phe Asn Trp Glu Pro Leu Arg Ile Tyr Gln Thr Glu Ser Ile Lys 
    130                 135                 140                 
Arg Ala Lys Glu Leu His Pro Thr Ala Asn Asp Ser Ala Val Lys Glu 
145                 150                 155                 160 
Ile Ala Glu Arg Gln Trp Glu Asp Ser Ala Lys Leu Tyr Met Leu Glu 
                165                 170                 175     
Thr Leu Arg Leu Ala Lys Lys Leu Arg Pro Gln Ala Pro Trp Cys Tyr 
            180                 185                 190         
Tyr Leu Phe Pro Asp Cys Tyr Asn Tyr Val Gly Lys Lys Pro Lys Asp 
        195                 200                 205             
Phe Gln Cys Ser Ala Ser Ile Arg Lys Gly Asn Asp Lys Leu Ser Trp 
    210                 215                 220                 
Leu Trp Lys Asp Ser Thr Ala Leu Cys Pro Ser Ile Tyr Val Tyr Glu 
225                 230                 235                 240 
Ser Gln Leu Asp Arg Tyr Ser Phe Glu Gln Arg Thr Trp Arg Asp Asn 
                245                 250                 255     
Glu Lys Leu Arg Glu Ala Leu Arg Val Ala Thr Arg Thr Ser Lys Ile 
            260                 265                 270         
Tyr Pro Tyr Val Asn Tyr Phe Asp Lys Glu Leu Ile Pro Glu Gln Glu 
        275                 280                 285             
Val Trp Arg Met Leu Ala Gln Ala Ala Ala Val Gly Gly Ser Gly Ala 
    290                 295                 300                 
Val Ile Trp Gly Ser Ser Ala Ala Val Ala Ser Glu Glu Leu Cys Lys 
305                 310                 315                 320 
Ser Leu Lys Gln Tyr Ile Ile Glu Thr Leu Gly Pro Ala Ala Glu Lys 
                325                 330                 335     
Val Ala Trp Arg Ser Asp Leu Cys Ser Lys Glu Ile Cys Asn Asn Gln 
            340                 345                 350         
Gly Arg Cys Thr Phe Pro Asp Asp Asp Tyr Ala Asn Ala Trp Lys Leu 
        355                 360                 365             
Phe Thr Asp Asp Thr Val Lys Phe Tyr Ala Gly Asn Ile Thr Cys Arg 
    370                 375                 380                 
Cys Ser Glu Asn Tyr Ser Gly Arg Phe Cys Glu Lys Lys Asn 
385                 390                 395             

<210> 61
<211> 405
<212> PRT
<213> Tityus serrulatus


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Tityus serrulatus with a N-terminal secretion signal

<400> 61
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Ala Asp Phe Lys Val Tyr Trp Glu Val Pro Ser Phe 
            20                  25                  30          
Leu Cys Ser Lys Arg Phe Lys Ile Asn Val Thr Glu Val Leu Thr Ser 
        35                  40                  45              
His Glu Ile Leu Val Asn Gln Gly Glu Ser Phe Asn Gly Asp Lys Ile 
    50                  55                  60                  
Val Ile Phe Tyr Glu Asn Gln Leu Gly Lys Tyr Pro His Ile Asp Ser 
65                  70                  75                  80  
Asn Asn Val Glu Ile Asn Gly Gly Ile Leu Gln Val Ala Asp Leu Ala 
                85                  90                  95      
Lys His Leu Lys Val Ala Lys Asp Asn Ile Thr Lys Phe Val Pro Asn 
            100                 105                 110         
Pro Asn Phe Asn Gly Val Gly Val Ile Asp Trp Glu Ala Trp Arg Pro 
        115                 120                 125             
Ser Trp Glu Phe Asn Trp Gly Lys Leu Lys Val Tyr Lys Glu Lys Ser 
    130                 135                 140                 
Ile Asp Leu Val Lys Ser Lys His Pro Glu Trp Pro Ser Asp Arg Val 
145                 150                 155                 160 
Glu Lys Val Ala Lys Glu Glu Trp Glu Glu Ser Ala Lys Glu Trp Met 
                165                 170                 175     
Val Lys Thr Leu Lys Leu Ala Gln Glu Met Arg Pro Asn Ala Val Trp 
            180                 185                 190         
Cys Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn Tyr Phe Gly Lys Asp Gln 
        195                 200                 205             
Pro Ser Gln Phe Ser Cys Ser Ser Arg Ile Gln Lys Glu Asn Ser Arg 
    210                 215                 220                 
Leu Ser Trp Leu Trp Asn Gln Ser Thr Ala Ile Cys Leu Ser Ile Tyr 
225                 230                 235                 240 
Ile Gln Glu Ser His Val Thr Lys Tyr Asn Met Ser Gln Arg Thr Trp 
                245                 250                 255     
Trp Ile Asp Ala Arg Leu Arg Glu Ala Ile Arg Val Ser Glu His Arg 
            260                 265                 270         
Pro Asn Ile Pro Ile Tyr Pro Tyr Ile Asn Tyr Ile Leu Pro Gly Thr 
        275                 280                 285             
Asn Gln Thr Val Pro Ala Met Asp Phe Lys Arg Thr Leu Gly Gln Ile 
    290                 295                 300                 
Ala Ser Leu Gly Leu Asp Gly Ala Leu Leu Trp Gly Ser Ser Tyr His 
305                 310                 315                 320 
Val Leu Thr Glu Ser Gln Cys Lys Ile Thr Ser Asp Tyr Val Lys Ser 
                325                 330                 335     
Val Ile Ala Pro Thr Val Ala Thr Val Val Leu Asn Thr Asn Arg Cys 
            340                 345                 350         
Ser Gln Ile Ile Cys Lys Gly Arg Gly Asn Cys Val Trp Pro Glu Glu 
        355                 360                 365             
Pro Phe Ser Ser Trp Lys Tyr Leu Val Asp Pro Lys Met Pro Val Phe 
    370                 375                 380                 
Lys Pro Thr Asn Ile His Cys Lys Cys Lys Gly Tyr Leu Gly Arg Tyr 
385                 390                 395                 400 
Cys Glu Ile Pro Lys 
                405 

<210> 62
<211> 435
<212> PRT
<213> Bos taurus


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from Bos
      taurus with a N-terminal secretion signal

<400> 62
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Gly Ser Arg Asp Pro Val Val Pro Asn Gln Pro Phe 
            20                  25                  30          
Thr Thr Ile Trp Asn Ala Asn Thr Glu Trp Cys Met Lys Lys His Gly 
        35                  40                  45              
Val Asp Val Asp Ile Ser Ile Phe Asp Val Val Thr Asn Pro Gly Gln 
    50                  55                  60                  
Thr Phe Arg Gly Pro Asn Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
65                  70                  75                  80  
Thr Tyr Pro Tyr Tyr Thr Ser Ala Gly Glu Pro Val Phe Gly Gly Leu 
                85                  90                  95      
Pro Gln Asn Ala Ser Leu Asn Ala His Leu Ala Arg Thr Phe Gln Asp 
            100                 105                 110         
Ile Leu Ala Ala Met Pro Glu Pro Arg Phe Ser Gly Leu Ala Val Ile 
        115                 120                 125             
Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
    130                 135                 140                 
Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Lys Gln His Pro 
145                 150                 155                 160 
Asp Trp Leu Ala Pro Arg Val Glu Ala Ala Ala Gln Asp Gln Phe Glu 
                165                 170                 175     
Gly Ala Ala Glu Glu Trp Met Ala Gly Thr Leu Lys Leu Gly Gln Ala 
            180                 185                 190         
Leu Arg Pro Gln Gly Leu Trp Gly Phe Tyr Asn Phe Pro Glu Cys Tyr 
        195                 200                 205             
Asn Tyr Asp Phe Lys Ser Pro Asn Tyr Thr Gly Arg Cys Pro Leu Asn 
    210                 215                 220                 
Ile Cys Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
225                 230                 235                 240 
Ala Leu Tyr Pro Ser Ile Tyr Leu Pro Ala Ala Leu Glu Gly Thr Lys 
                245                 250                 255     
Lys Thr Gln Met Phe Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
            260                 265                 270         
Ala Ala Gly Ala Gly Asp Pro Lys Leu Pro Val Leu Pro Tyr Met Gln 
        275                 280                 285             
Leu Phe Tyr Asp Met Thr Asn His Phe Leu Pro Ala Glu Glu Leu Glu 
    290                 295                 300                 
His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
305                 310                 315                 320 
Trp Val Ser Trp Leu Ser Thr Ser Thr Lys Glu Ser Cys Gln Ala Ile 
                325                 330                 335     
Lys Glu Tyr Val Asp Thr Thr Leu Gly Pro Ser Ile Leu Asn Val Thr 
            340                 345                 350         
Ser Gly Ala Arg Leu Cys Ser Gln Val Leu Cys Ser Gly His Gly Arg 
        355                 360                 365             
Cys Ala Arg Arg Pro Ser Tyr Pro Lys Ala Arg Leu Ile Leu Asn Ser 
    370                 375                 380                 
Thr Ser Phe Ser Ile Lys Pro Thr Pro Gly Gly Gly Pro Leu Thr Leu 
385                 390                 395                 400 
Gln Gly Ala Leu Ser Leu Glu Asp Arg Leu Arg Met Ala Val Glu Phe 
                405                 410                 415     
Glu Cys Arg Cys Tyr Arg Gly Trp Arg Gly Thr Arg Cys Glu Gln Trp 
            420                 425                 430         
Gly Met Trp 
        435 

<210> 63
<211> 378
<212> PRT
<213> Apis mellifera


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from Apis
      mellifera with a N-terminal secretion signal

<400> 63
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Leu Leu Leu Gly Phe Val Gln Ser Thr Pro Asp Asn 
            20                  25                  30          
Asn Lys Thr Val Arg Glu Phe Asn Val Tyr Trp Asn Val Pro Thr Phe 
        35                  40                  45              
Met Cys His Lys Tyr Gly Leu Arg Phe Glu Glu Val Ser Glu Lys Tyr 
    50                  55                  60                  
Gly Ile Leu Gln Asn Trp Met Asp Lys Phe Arg Gly Glu Glu Ile Ala 
65                  70                  75                  80  
Ile Leu Tyr Asp Pro Gly Met Phe Pro Ala Leu Leu Lys Asp Pro Asn 
                85                  90                  95      
Gly Asn Val Val Ala Arg Asn Gly Gly Val Pro Gln Leu Gly Asn Leu 
            100                 105                 110         
Thr Lys His Leu Gln Val Phe Arg Asp His Leu Ile Asn Gln Ile Pro 
        115                 120                 125             
Asp Lys Ser Phe Pro Gly Val Gly Val Ile Asp Phe Glu Ser Trp Arg 
    130                 135                 140                 
Pro Ile Phe Arg Gln Asn Trp Ala Ser Leu Gln Pro Tyr Lys Lys Leu 
145                 150                 155                 160 
Ser Val Glu Val Val Arg Arg Glu His Pro Phe Trp Asp Asp Gln Arg 
                165                 170                 175     
Val Glu Gln Glu Ala Lys Arg Arg Phe Glu Lys Tyr Gly Gln Leu Phe 
            180                 185                 190         
Met Glu Glu Thr Leu Lys Ala Ala Lys Arg Met Arg Pro Ala Ala Asn 
        195                 200                 205             
Trp Gly Tyr Tyr Ala Tyr Pro Tyr Cys Tyr Asn Leu Thr Pro Asn Gln 
    210                 215                 220                 
Pro Ser Ala Gln Cys Glu Ala Thr Thr Met Gln Glu Asn Asp Lys Met 
225                 230                 235                 240 
Ser Trp Leu Phe Glu Ser Glu Asp Val Leu Leu Pro Ser Val Tyr Leu 
                245                 250                 255     
Arg Trp Asn Leu Thr Ser Gly Glu Arg Val Gly Leu Val Gly Gly Arg 
            260                 265                 270         
Val Lys Glu Ala Leu Arg Ile Ala Arg Gln Met Thr Thr Ser Arg Lys 
        275                 280                 285             
Lys Val Leu Pro Tyr Tyr Trp Tyr Lys Tyr Gln Asp Arg Arg Asp Thr 
    290                 295                 300                 
Asp Leu Ser Arg Ala Asp Leu Glu Ala Thr Leu Arg Lys Ile Thr Asp 
305                 310                 315                 320 
Leu Gly Ala Asp Gly Phe Ile Ile Trp Gly Ser Ser Asp Asp Ile Asn 
                325                 330                 335     
Thr Lys Ala Lys Cys Leu Gln Phe Arg Glu Tyr Leu Asn Asn Glu Leu 
            340                 345                 350         
Gly Pro Ala Val Lys Arg Ile Ala Leu Asn Asn Asn Ala Asn Asp Arg 
        355                 360                 365             
Leu Thr Val Asp Val Ser Val Asp Gln Val 
    370                 375             

<210> 64
<211> 434
<212> PRT
<213> Macaca mulatta


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Macaca mulatta with a N-terminal secretion signal

<400> 64
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Ser Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe Ala 
            20                  25                  30          
Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Ser Val 
        35                  40                  45              
Asp Val Asp Val Ser Ile Phe Asp Val Val Ala Asn Pro Gly Gln Thr 
    50                  55                  60                  
Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly Thr 
65                  70                  75                  80  
Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro 
                85                  90                  95      
Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp Ile 
            100                 105                 110         
Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile Asp 
        115                 120                 125             
Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys Asp 
    130                 135                 140                 
Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro Asp 
145                 150                 155                 160 
Trp Pro Val Thr Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln Gly 
                165                 170                 175     
Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala Leu 
            180                 185                 190         
Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr Asn 
        195                 200                 205             
Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly Ile 
    210                 215                 220                 
Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala 
225                 230                 235                 240 
Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly Lys 
                245                 250                 255     
Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala 
            260                 265                 270         
Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile 
        275                 280                 285             
Phe Tyr Asp Met Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu His 
    290                 295                 300                 
Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp 
305                 310                 315                 320 
Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys 
                325                 330                 335     
Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser 
            340                 345                 350         
Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Ser His Gly Arg Cys 
        355                 360                 365             
Val Arg Arg Pro Ser His Pro Lys Ala Leu Leu Ile Leu Asn Pro Ala 
    370                 375                 380                 
Ser Phe Ser Ile Gln Leu Thr Pro Asp Gly Gly Pro Leu Ser Leu Arg 
385                 390                 395                 400 
Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys 
                405                 410                 415     
Cys Arg Cys Tyr Pro Gly Trp Gln Gly Pro Trp Cys Glu Gln Lys Ser 
            420                 425                 430         
Met Trp 
        

<210> 65
<211> 360
<212> PRT
<213> Vespa magnifica


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Vespa magnifica with a N-terminal secretion signal

<400> 65
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Asp Ser Cys Gly Ser Asn Cys Glu Lys Ser Glu Arg 
            20                  25                  30          
Pro Lys Arg Val Phe Asn Ile Tyr Trp Asn Val Pro Thr Phe Met Cys 
        35                  40                  45              
His Gln Tyr Gly Leu Tyr Phe Asp Glu Val Thr Asn Phe Asn Ile Lys 
    50                  55                  60                  
His Asn Ser Lys Asp Asn Phe Gln Gly Asp Lys Ile Ala Ile Phe Tyr 
65                  70                  75                  80  
Asp Pro Gly Glu Phe Pro Ala Leu Leu Pro Leu Asn Tyr Gly Lys Tyr 
                85                  90                  95      
Lys Ile Arg Asn Gly Gly Val Pro Gln Glu Gly Asn Ile Thr Ile His 
            100                 105                 110         
Leu Gln Arg Phe Ile Glu Tyr Leu Asp Lys Thr Tyr Pro Asn Arg Asn 
        115                 120                 125             
Phe Ser Gly Ile Gly Val Ile Asp Phe Glu Arg Trp Arg Pro Ile Phe 
    130                 135                 140                 
Arg Gln Asn Trp Gly Asn Met Lys Ile Tyr Lys Asn Phe Ser Ile Asp 
145                 150                 155                 160 
Leu Val Arg Lys Glu His Pro Phe Trp Asn Lys Lys Met Ile Glu Leu 
                165                 170                 175     
Glu Ala Ser Lys Arg Phe Glu Lys Tyr Ala Arg Leu Phe Met Glu Glu 
            180                 185                 190         
Thr Leu Lys Leu Ala Lys Lys Thr Arg Lys Gln Ala Asp Trp Gly Tyr 
        195                 200                 205             
Tyr Gly Tyr Pro Tyr Cys Phe Asn Met Ser Pro Thr Asn Phe Val Pro 
    210                 215                 220                 
Asp Cys Asp Val Thr Ala Arg Asp Glu Asn Asn Glu Met Ser Trp Leu 
225                 230                 235                 240 
Phe Asn Asn Gln Asn Val Leu Leu Pro Ser Val Tyr Ile Arg Arg Glu 
                245                 250                 255     
Leu Thr Pro Asp Gln Arg Ile Gly Leu Val Gln Gly Arg Val Lys Glu 
            260                 265                 270         
Ala Val Arg Ile Ser Asn Lys Leu Lys His Ser Pro Lys Val Phe Ser 
        275                 280                 285             
Tyr Trp Trp Tyr Val Tyr Gln Asp Glu Thr Asn Thr Phe Leu Thr Glu 
    290                 295                 300                 
Thr Asp Val Lys Lys Thr Phe Gln Glu Ile Val Ile Asn Gly Gly Asp 
305                 310                 315                 320 
Gly Ile Ile Ile Trp Gly Ser Ser Ser Asp Val Asn Ser Leu Ser Lys 
                325                 330                 335     
Cys Thr Arg Leu Arg Glu Tyr Leu Leu Thr Val Leu Gly Pro Ile Ala 
            340                 345                 350         
Val Asn Val Thr Glu Ala Val Asn 
        355                 360 

<210> 66
<211> 468
<212> PRT
<213> Cupiennius salei


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Cupiennius salei with a N-terminal secretion signal and a
      C-terminal anchoring signal

<400> 66
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Phe Lys Ile Tyr Trp Asn Val Pro Thr Phe Gln Cys 
            20                  25                  30          
Thr His Asn Tyr Lys Ile Asp Tyr Val Lys Leu Leu Ser Thr Tyr Gly 
        35                  40                  45              
Ile Gln Val Asn Asp Gly Gly Lys Phe Gln Gly Asn Gln Val Thr Ile 
    50                  55                  60                  
Phe Tyr Glu Thr Gln Leu Gly Leu Tyr Pro Arg Ile Leu Lys Ser Gly 
65                  70                  75                  80  
Lys Met Glu Asn Gly Gly Ile Pro Gln Arg Gly Asn Phe Glu Lys His 
                85                  90                  95      
Leu Glu Lys Ala Ser Thr Asp Leu Gln Lys Val Ile Pro Trp Lys Glu 
            100                 105                 110         
Phe Ser Gly Leu Gly Val Ile Asp Trp Glu Ala Trp Arg Pro Thr Trp 
        115                 120                 125             
Glu Phe Asn Trp Glu Pro Leu Arg Ile Tyr Gln Thr Glu Ser Ile Lys 
    130                 135                 140                 
Arg Ala Lys Glu Leu His Pro Thr Ala Asn Asp Ser Ala Val Lys Glu 
145                 150                 155                 160 
Ile Ala Glu Arg Gln Trp Glu Asp Ser Ala Lys Leu Tyr Met Leu Glu 
                165                 170                 175     
Thr Leu Arg Leu Ala Lys Lys Leu Arg Pro Gln Ala Pro Trp Cys Tyr 
            180                 185                 190         
Tyr Leu Phe Pro Asp Cys Tyr Asn Tyr Val Gly Lys Lys Pro Lys Asp 
        195                 200                 205             
Phe Gln Cys Ser Ala Ser Ile Arg Lys Gly Asn Asp Lys Leu Ser Trp 
    210                 215                 220                 
Leu Trp Lys Asp Ser Thr Ala Leu Cys Pro Ser Ile Tyr Val Tyr Glu 
225                 230                 235                 240 
Ser Gln Leu Asp Arg Tyr Ser Phe Glu Gln Arg Thr Trp Arg Asp Asn 
                245                 250                 255     
Glu Lys Leu Arg Glu Ala Leu Arg Val Ala Thr Arg Thr Ser Lys Ile 
            260                 265                 270         
Tyr Pro Tyr Val Asn Tyr Phe Asp Lys Glu Leu Ile Pro Glu Gln Glu 
        275                 280                 285             
Val Trp Arg Met Leu Ala Gln Ala Ala Ala Val Gly Gly Ser Gly Ala 
    290                 295                 300                 
Val Ile Trp Gly Ser Ser Ala Ala Val Ala Ser Glu Glu Leu Cys Lys 
305                 310                 315                 320 
Ser Leu Lys Gln Tyr Ile Ile Glu Thr Leu Gly Pro Ala Ala Glu Lys 
                325                 330                 335     
Val Ala Trp Arg Ser Asp Leu Cys Ser Lys Glu Ile Cys Asn Asn Gln 
            340                 345                 350         
Gly Arg Cys Thr Phe Pro Asp Asp Asp Tyr Ala Asn Ala Trp Lys Leu 
        355                 360                 365             
Phe Thr Asp Asp Thr Val Lys Phe Tyr Ala Gly Asn Ile Thr Cys Arg 
    370                 375                 380                 
Cys Ser Glu Asn Tyr Ser Gly Arg Phe Cys Glu Lys Lys Asn Gly Ser 
385                 390                 395                 400 
Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala Thr Thr Thr Ala 
                405                 410                 415     
Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser Thr Val Glu Thr 
            420                 425                 430         
Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu Asn Gly 
        435                 440                 445             
Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala Leu Ala Ala Ala 
    450                 455                 460                 
Ala Met Leu Leu 
465             

<210> 67
<211> 475
<212> PRT
<213> Tityus serrulatus


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Tityus serrulatus with a N-terminal secretion signal and a
      C-terminal anchoring signal

<400> 67
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Ala Asp Phe Lys Val Tyr Trp Glu Val Pro Ser Phe 
            20                  25                  30          
Leu Cys Ser Lys Arg Phe Lys Ile Asn Val Thr Glu Val Leu Thr Ser 
        35                  40                  45              
His Glu Ile Leu Val Asn Gln Gly Glu Ser Phe Asn Gly Asp Lys Ile 
    50                  55                  60                  
Val Ile Phe Tyr Glu Asn Gln Leu Gly Lys Tyr Pro His Ile Asp Ser 
65                  70                  75                  80  
Asn Asn Val Glu Ile Asn Gly Gly Ile Leu Gln Val Ala Asp Leu Ala 
                85                  90                  95      
Lys His Leu Lys Val Ala Lys Asp Asn Ile Thr Lys Phe Val Pro Asn 
            100                 105                 110         
Pro Asn Phe Asn Gly Val Gly Val Ile Asp Trp Glu Ala Trp Arg Pro 
        115                 120                 125             
Ser Trp Glu Phe Asn Trp Gly Lys Leu Lys Val Tyr Lys Glu Lys Ser 
    130                 135                 140                 
Ile Asp Leu Val Lys Ser Lys His Pro Glu Trp Pro Ser Asp Arg Val 
145                 150                 155                 160 
Glu Lys Val Ala Lys Glu Glu Trp Glu Glu Ser Ala Lys Glu Trp Met 
                165                 170                 175     
Val Lys Thr Leu Lys Leu Ala Gln Glu Met Arg Pro Asn Ala Val Trp 
            180                 185                 190         
Cys Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn Tyr Phe Gly Lys Asp Gln 
        195                 200                 205             
Pro Ser Gln Phe Ser Cys Ser Ser Arg Ile Gln Lys Glu Asn Ser Arg 
    210                 215                 220                 
Leu Ser Trp Leu Trp Asn Gln Ser Thr Ala Ile Cys Leu Ser Ile Tyr 
225                 230                 235                 240 
Ile Gln Glu Ser His Val Thr Lys Tyr Asn Met Ser Gln Arg Thr Trp 
                245                 250                 255     
Trp Ile Asp Ala Arg Leu Arg Glu Ala Ile Arg Val Ser Glu His Arg 
            260                 265                 270         
Pro Asn Ile Pro Ile Tyr Pro Tyr Ile Asn Tyr Ile Leu Pro Gly Thr 
        275                 280                 285             
Asn Gln Thr Val Pro Ala Met Asp Phe Lys Arg Thr Leu Gly Gln Ile 
    290                 295                 300                 
Ala Ser Leu Gly Leu Asp Gly Ala Leu Leu Trp Gly Ser Ser Tyr His 
305                 310                 315                 320 
Val Leu Thr Glu Ser Gln Cys Lys Ile Thr Ser Asp Tyr Val Lys Ser 
                325                 330                 335     
Val Ile Ala Pro Thr Val Ala Thr Val Val Leu Asn Thr Asn Arg Cys 
            340                 345                 350         
Ser Gln Ile Ile Cys Lys Gly Arg Gly Asn Cys Val Trp Pro Glu Glu 
        355                 360                 365             
Pro Phe Ser Ser Trp Lys Tyr Leu Val Asp Pro Lys Met Pro Val Phe 
    370                 375                 380                 
Lys Pro Thr Asn Ile His Cys Lys Cys Lys Gly Tyr Leu Gly Arg Tyr 
385                 390                 395                 400 
Cys Glu Ile Pro Lys Gly Ser Ala Ile Ser Gln Ile Thr Asp Gly Gln 
                405                 410                 415     
Ile Gln Ala Thr Thr Thr Ala Thr Thr Glu Ala Thr Thr Thr Ala Ala 
            420                 425                 430         
Pro Ser Ser Thr Val Glu Thr Val Ser Pro Ser Ser Thr Glu Thr Ile 
        435                 440                 445             
Ser Gln Gln Thr Glu Asn Gly Ala Ala Lys Ala Ala Val Gly Met Gly 
    450                 455                 460                 
Ala Gly Ala Leu Ala Ala Ala Ala Met Leu Leu 
465                 470                 475 

<210> 68
<211> 448
<212> PRT
<213> Bos taurus


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from Bos
      taurus with a N-terminal secretion signal and a C-terminal
      anchoring signal

<400> 68
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Leu Leu Leu Gly Phe Val Gln Ser Thr Pro Asp Asn 
            20                  25                  30          
Asn Lys Thr Val Arg Glu Phe Asn Val Tyr Trp Asn Val Pro Thr Phe 
        35                  40                  45              
Met Cys His Lys Tyr Gly Leu Arg Phe Glu Glu Val Ser Glu Lys Tyr 
    50                  55                  60                  
Gly Ile Leu Gln Asn Trp Met Asp Lys Phe Arg Gly Glu Glu Ile Ala 
65                  70                  75                  80  
Ile Leu Tyr Asp Pro Gly Met Phe Pro Ala Leu Leu Lys Asp Pro Asn 
                85                  90                  95      
Gly Asn Val Val Ala Arg Asn Gly Gly Val Pro Gln Leu Gly Asn Leu 
            100                 105                 110         
Thr Lys His Leu Gln Val Phe Arg Asp His Leu Ile Asn Gln Ile Pro 
        115                 120                 125             
Asp Lys Ser Phe Pro Gly Val Gly Val Ile Asp Phe Glu Ser Trp Arg 
    130                 135                 140                 
Pro Ile Phe Arg Gln Asn Trp Ala Ser Leu Gln Pro Tyr Lys Lys Leu 
145                 150                 155                 160 
Ser Val Glu Val Val Arg Arg Glu His Pro Phe Trp Asp Asp Gln Arg 
                165                 170                 175     
Val Glu Gln Glu Ala Lys Arg Arg Phe Glu Lys Tyr Gly Gln Leu Phe 
            180                 185                 190         
Met Glu Glu Thr Leu Lys Ala Ala Lys Arg Met Arg Pro Ala Ala Asn 
        195                 200                 205             
Trp Gly Tyr Tyr Ala Tyr Pro Tyr Cys Tyr Asn Leu Thr Pro Asn Gln 
    210                 215                 220                 
Pro Ser Ala Gln Cys Glu Ala Thr Thr Met Gln Glu Asn Asp Lys Met 
225                 230                 235                 240 
Ser Trp Leu Phe Glu Ser Glu Asp Val Leu Leu Pro Ser Val Tyr Leu 
                245                 250                 255     
Arg Trp Asn Leu Thr Ser Gly Glu Arg Val Gly Leu Val Gly Gly Arg 
            260                 265                 270         
Val Lys Glu Ala Leu Arg Ile Ala Arg Gln Met Thr Thr Ser Arg Lys 
        275                 280                 285             
Lys Val Leu Pro Tyr Tyr Trp Tyr Lys Tyr Gln Asp Arg Arg Asp Thr 
    290                 295                 300                 
Asp Leu Ser Arg Ala Asp Leu Glu Ala Thr Leu Arg Lys Ile Thr Asp 
305                 310                 315                 320 
Leu Gly Ala Asp Gly Phe Ile Ile Trp Gly Ser Ser Asp Asp Ile Asn 
                325                 330                 335     
Thr Lys Ala Lys Cys Leu Gln Phe Arg Glu Tyr Leu Asn Asn Glu Leu 
            340                 345                 350         
Gly Pro Ala Val Lys Arg Ile Ala Leu Asn Asn Asn Ala Asn Asp Arg 
        355                 360                 365             
Leu Thr Val Asp Val Ser Val Asp Gln Val Gly Ser Ala Ile Ser Gln 
    370                 375                 380                 
Ile Thr Asp Gly Gln Ile Gln Ala Thr Thr Thr Ala Thr Thr Glu Ala 
385                 390                 395                 400 
Thr Thr Thr Ala Ala Pro Ser Ser Thr Val Glu Thr Val Ser Pro Ser 
                405                 410                 415     
Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu Asn Gly Ala Ala Lys Ala 
            420                 425                 430         
Ala Val Gly Met Gly Ala Gly Ala Leu Ala Ala Ala Ala Met Leu Leu 
        435                 440                 445             



<210> 69
<211> 448
<212> PRT
<213> Apis mellifera


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from Apis
      mellifera with a N-terminal secretion signal and a C-terminal
      anchoring signal

<400> 69
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Leu Leu Leu Gly Phe Val Gln Ser Thr Pro Asp Asn 
            20                  25                  30          
Asn Lys Thr Val Arg Glu Phe Asn Val Tyr Trp Asn Val Pro Thr Phe 
        35                  40                  45              
Met Cys His Lys Tyr Gly Leu Arg Phe Glu Glu Val Ser Glu Lys Tyr 
    50                  55                  60                  
Gly Ile Leu Gln Asn Trp Met Asp Lys Phe Arg Gly Glu Glu Ile Ala 
65                  70                  75                  80  
Ile Leu Tyr Asp Pro Gly Met Phe Pro Ala Leu Leu Lys Asp Pro Asn 
                85                  90                  95      
Gly Asn Val Val Ala Arg Asn Gly Gly Val Pro Gln Leu Gly Asn Leu 
            100                 105                 110         
Thr Lys His Leu Gln Val Phe Arg Asp His Leu Ile Asn Gln Ile Pro 
        115                 120                 125             
Asp Lys Ser Phe Pro Gly Val Gly Val Ile Asp Phe Glu Ser Trp Arg 
    130                 135                 140                 
Pro Ile Phe Arg Gln Asn Trp Ala Ser Leu Gln Pro Tyr Lys Lys Leu 
145                 150                 155                 160 
Ser Val Glu Val Val Arg Arg Glu His Pro Phe Trp Asp Asp Gln Arg 
                165                 170                 175     
Val Glu Gln Glu Ala Lys Arg Arg Phe Glu Lys Tyr Gly Gln Leu Phe 
            180                 185                 190         
Met Glu Glu Thr Leu Lys Ala Ala Lys Arg Met Arg Pro Ala Ala Asn 
        195                 200                 205             
Trp Gly Tyr Tyr Ala Tyr Pro Tyr Cys Tyr Asn Leu Thr Pro Asn Gln 
    210                 215                 220                 
Pro Ser Ala Gln Cys Glu Ala Thr Thr Met Gln Glu Asn Asp Lys Met 
225                 230                 235                 240 
Ser Trp Leu Phe Glu Ser Glu Asp Val Leu Leu Pro Ser Val Tyr Leu 
                245                 250                 255     
Arg Trp Asn Leu Thr Ser Gly Glu Arg Val Gly Leu Val Gly Gly Arg 
            260                 265                 270         
Val Lys Glu Ala Leu Arg Ile Ala Arg Gln Met Thr Thr Ser Arg Lys 
        275                 280                 285             
Lys Val Leu Pro Tyr Tyr Trp Tyr Lys Tyr Gln Asp Arg Arg Asp Thr 
    290                 295                 300                 
Asp Leu Ser Arg Ala Asp Leu Glu Ala Thr Leu Arg Lys Ile Thr Asp 
305                 310                 315                 320 
Leu Gly Ala Asp Gly Phe Ile Ile Trp Gly Ser Ser Asp Asp Ile Asn 
                325                 330                 335     
Thr Lys Ala Lys Cys Leu Gln Phe Arg Glu Tyr Leu Asn Asn Glu Leu 
            340                 345                 350         
Gly Pro Ala Val Lys Arg Ile Ala Leu Asn Asn Asn Ala Asn Asp Arg 
        355                 360                 365             
Leu Thr Val Asp Val Ser Val Asp Gln Val Gly Ser Ala Ile Ser Gln 
    370                 375                 380                 
Ile Thr Asp Gly Gln Ile Gln Ala Thr Thr Thr Ala Thr Thr Glu Ala 
385                 390                 395                 400 
Thr Thr Thr Ala Ala Pro Ser Ser Thr Val Glu Thr Val Ser Pro Ser 
                405                 410                 415     
Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu Asn Gly Ala Ala Lys Ala 
            420                 425                 430         
Ala Val Gly Met Gly Ala Gly Ala Leu Ala Ala Ala Ala Met Leu Leu 
        435                 440                 445             



<210> 70
<211> 504
<212> PRT
<213> Macaca mulatta


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Macaca mulatta with a N-terminal secretion signal and a
      C-terminal anchoring signal

<400> 70
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala Ser Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe Ala 
            20                  25                  30          
Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Ser Val 
        35                  40                  45              
Asp Val Asp Val Ser Ile Phe Asp Val Val Ala Asn Pro Gly Gln Thr 
    50                  55                  60                  
Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly Thr 
65                  70                  75                  80  
Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro 
                85                  90                  95      
Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp Ile 
            100                 105                 110         
Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile Asp 
        115                 120                 125             
Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys Asp 
    130                 135                 140                 
Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro Asp 
145                 150                 155                 160 
Trp Pro Val Thr Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln Gly 
                165                 170                 175     
Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala Leu 
            180                 185                 190         
Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr Asn 
        195                 200                 205             
Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly Ile 
    210                 215                 220                 
Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala 
225                 230                 235                 240 
Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly Lys 
                245                 250                 255     
Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala 
            260                 265                 270         
Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile 
        275                 280                 285             
Phe Tyr Asp Met Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu His 
    290                 295                 300                 
Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp 
305                 310                 315                 320 
Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys 
                325                 330                 335     
Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser 
            340                 345                 350         
Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Ser His Gly Arg Cys 
        355                 360                 365             
Val Arg Arg Pro Ser His Pro Lys Ala Leu Leu Ile Leu Asn Pro Ala 
    370                 375                 380                 
Ser Phe Ser Ile Gln Leu Thr Pro Asp Gly Gly Pro Leu Ser Leu Arg 
385                 390                 395                 400 
Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys 
                405                 410                 415     
Cys Arg Cys Tyr Pro Gly Trp Gln Gly Pro Trp Cys Glu Gln Lys Ser 
            420                 425                 430         
Met Trp Gly Ser Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala 
        435                 440                 445             
Thr Thr Thr Ala Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser 
    450                 455                 460                 
Thr Val Glu Thr Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln 
465                 470                 475                 480 
Thr Glu Asn Gly Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala 
                485                 490                 495     
Leu Ala Ala Ala Ala Met Leu Leu 
            500                 

<210> 71
<211> 360
<212> PRT
<213> Vespa magnifica


<220> 
<223> amino acid sequence of hyaluronidase (HYAL) originating from
      Vespa magnifica with a N-terminal secretion signal and a
      C-terminal anchoring signal

<400> 71
Asp Asn Phe Gln Gly Asp Lys Ile Ala Ile Phe Tyr Asp Pro Gly Glu 
1               5                   10                  15      
Phe Pro Ala Leu Leu Pro Leu Asn Tyr Gly Lys Tyr Lys Ile Arg Asn 
            20                  25                  30          
Gly Gly Val Pro Gln Glu Gly Asn Ile Thr Ile His Leu Gln Arg Phe 
        35                  40                  45              
Ile Glu Tyr Leu Asp Lys Thr Tyr Pro Asn Arg Asn Phe Ser Gly Ile 
    50                  55                  60                  
Gly Val Ile Asp Phe Glu Arg Trp Arg Pro Ile Phe Arg Gln Asn Trp 
65                  70                  75                  80  
Gly Asn Met Lys Ile Tyr Lys Asn Phe Ser Ile Asp Leu Val Arg Lys 
                85                  90                  95      
Glu His Pro Phe Trp Asn Lys Lys Met Ile Glu Leu Glu Ala Ser Lys 
            100                 105                 110         
Arg Phe Glu Lys Tyr Ala Arg Leu Phe Met Glu Glu Thr Leu Lys Leu 
        115                 120                 125             
Ala Lys Lys Thr Arg Lys Gln Ala Asp Trp Gly Tyr Tyr Gly Tyr Pro 
    130                 135                 140                 
Tyr Cys Phe Asn Met Ser Pro Thr Asn Phe Val Pro Asp Cys Asp Val 
145                 150                 155                 160 
Thr Ala Arg Asp Glu Asn Asn Glu Met Ser Trp Leu Phe Asn Asn Gln 
                165                 170                 175     
Asn Val Leu Leu Pro Ser Val Tyr Ile Arg Arg Glu Leu Thr Pro Asp 
            180                 185                 190         
Gln Arg Ile Gly Leu Val Gln Gly Arg Val Lys Glu Ala Val Arg Ile 
        195                 200                 205             
Ser Asn Lys Leu Lys His Ser Pro Lys Val Phe Ser Tyr Trp Trp Tyr 
    210                 215                 220                 
Val Tyr Gln Asp Glu Thr Asn Thr Phe Leu Thr Glu Thr Asp Val Lys 
225                 230                 235                 240 
Lys Thr Phe Gln Glu Ile Val Ile Asn Gly Gly Asp Gly Ile Ile Ile 
                245                 250                 255     
Trp Gly Ser Ser Ser Asp Val Asn Ser Leu Ser Lys Cys Thr Arg Leu 
            260                 265                 270         
Arg Glu Tyr Leu Leu Thr Val Leu Gly Pro Ile Ala Val Asn Val Thr 
        275                 280                 285             
Glu Ala Val Asn Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala 
    290                 295                 300                 
Thr Thr Thr Ala Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser 
305                 310                 315                 320 
Thr Val Glu Thr Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln 
                325                 330                 335     
Thr Glu Asn Gly Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala 
            340                 345                 350         
Leu Ala Ala Ala Ala Met Leu Leu 
        355                 360 

<210> 72
<211> 2154
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> nucleic acid sequence of glutamine-fructose-6-phosphate
      amidotransferase (GFA1) originating from Saccharomyces cerevisiae

<400> 72
atgtgtggta tctttggtta ctgcaattat ctagtggaaa gatccagagg agaaattatc      60

gacaccttag tggatggttt acaaagatta gaatatagag gctatgattc caccggtatt     120

gctatcgatg gtgacgaagc tgattctact ttcatctata agcaaatcgg taaagtgagt     180

gctttgaaag aggagattac taagcaaaat ccgaacagag acgttacttt tgtctctcat     240

tgtggtattg cgcatactag atgggctact cacggtcgac cagaacaagt taactgtcac     300

cctcaaagat ctgacccaga agaccaattt gtggtcgttc ataatggtat catcacaaat     360

tttagagaac tgaagactct tttaattaac aaaggttata aattcgaaag tgataccgat     420

accgagtgta ttgctaaact atatttgcat ttatacaata caaatttaca aaatgggcat     480

gacttagatt tccacgaatt aaccaagcta gttcttttag aactagaagg ttcatacggg     540

ttattatgta aatcttgtca ctatcctaat gaggttatcg ccactagaaa agggtcccct     600

ttactgattg gtgtcaaatc tgaaaaaaaa ctaaaagtcg acttcgtgga tgtggaattt     660

cccgaagaaa acgctggtca accggaaatt ccattgaaat ctaacaacaa atcatttggc     720

ttgggcccaa agaaagctcg tgaatttgaa gctggttccc aaaatgccaa tttactacca     780

attgccgcca atgaatttaa cttgagacat tctcaatcca gggctttcct atcagaagat     840

ggatctccaa caccggtgga attttttgtt tcttcggatg cggcatctgt tgttaaacat     900

accaagaagg tgctattttt agaagatgac gatttggctc atatttacga tggtgagtta     960

catattcata gatctagaag agaagtaggc gcatcaatga caaggtccat tcaaacttta    1020

gagatggagt tagctcagat catgaagggc ccttacgacc attttatgca aaaggaaatc    1080

tatgagcaac cagaatctac tttcaatact atgagaggta gaatcgacta tgaaaataat    1140

aaagtgatat tgggtggttt aaaggcatgg ttaccagttg tcagaagagc acggagactg    1200

atcatgatcg catgcggtac ttcttatcat tcatgtttgg ctactcgtgc tatcttcgaa    1260

gaattatcag atatcccagt tagtgtggaa ttagcgtctg actttctgga cagaaaatgc    1320

cctgtcttca gagacgatgt atgcgtgttt gtttcacaaa gtggtgaaac tgcggatacc    1380

atgctggctc taaattattg tttagaaaga ggagccttaa ctgtcggaat tgttaacagt    1440

gttggttctt ctatctctcg tgtcacccac tgtggtgttc atattaacgc tggtcctgaa    1500

attggtgttg cctctacaaa agcttatact tcccagtata ttgccttagt gatgtttgct    1560

ctatcgctgt cagatgaccg tgtatcgaaa atagacagaa gaattgaaat cattcaaggc    1620

ttgaagttaa tcccgggcca aattaagcag gtattaaagc tggaaccaag aataaaaaag    1680

ctctgtgcga ctgaattaaa ggatcaaaaa tctctattgt tattgggtag aggttaccaa    1740

tttgctgctg ctctggaagg tgctttgaag atcaaagaaa tttcttatat gcattctgaa    1800

ggtgttttgg caggtgagtt gaagcacggt gtcttggcct tggtggacga aaacttgcca    1860

atcattgctt ttggtaccag agactctcta ttccctaaag tagtttcctc tattgagcaa    1920

gttactgtaa gaaagggcca tccaattatt atttgtaacg aaaatgatga agtgtgggcg    1980

caaaaatcta aatcaatcga cctgcaaacc ttagaagttc cacaaactgt tgattgttta    2040

caaggtctaa ttaatattat tccattacaa ctaatgtcat attggttggc tgttaataaa    2100

gggattgatg ttgattttcc aagaaacttg gctaaatctg ttaccgtcga ataa          2154


<210> 73
<211> 1788
<212> DNA
<213> Chlorella virus


<220> 
<223> reencoded nucleic acid sequence of glutamine-fructose-6-phosphate
      amidotransferase (GFA1) originating from Chlorella virus 1
      (PBCV-1)

<400> 73
atgtgcggga tcttcggtgc tgtgtcgaac aataatagca tagaagtttc catcaagggt      60

atacagaagc tagagtaccg cgggtacgat tcgtgtggaa tagcctatac agacggaggc     120

gccattgaac ggatcaggtc aatagatggg atcgacgact taaggaagaa aacaataaca     180

gagtcttccc cggtagctat cgctcattca aggtggagta ccactgggat tccaagtgtt     240

gtgaacgccc acccgcacat ctctcggggc acgtctggat gcgagtcgcg cattgcagtc     300

gtacacaatg gcattattga aaattaccag cagatccgca agtacttgat aaatcttggg     360

tatactttcg attcacagac cgacacggaa gtcattgctc atctaataga ctcgcagtat     420

aacgggaaca tcctgcacac cgtccaaatg gcagttaagc acctcaaagg aagctacgcc     480

atagcagtca tgtgccataa ggagtccggg aagatcgtgg tggcaaaaca gaagagtccg     540

ttggtattgg gtataggaag cgacggagct tattatatcg catcggacgt attggctctt     600

cccactaaca aagtggtcta cataagtgac ggattctctg ctgagttaag tcctggatcg     660

atgactatct atgatctgga tggcaataag gtagaatacg aggtggaaga cgttgaaatg     720

gagcagacgt cgatgtcttt agataacttt gatcactaca tgatcaaaga gatcaatgaa     780

cagccgatat caattctcaa tactattaag aacaaaggat tctatgcaga gatatttggt     840

gatctagcac atgaaatatt tcagaagatc gacaatatat tgattctagc ctgcggaact     900

tcgtatcatg caggtctcgt cgggaagcaa tggatagaga ccatctcacg catcccggtg     960

gatgttcata ttgcaagcga gtatgagccg acaattccac gagccaatac acttgtgata    1020

acgattagtc aaagcggcga gactgcggat acaatcgcag cccttcaacg agcgcaaaac    1080

gcaggaatga tatacacttt gtgtatctgc aacagcccca agtcaactct agtgcgcgag    1140

tcgataatga aatacataac caaatgcggt tcagaagttt ctgttgccag tactaaagca    1200

tttacgtcgc aacttgtggt gttgtatatg cttgcgaacg ttcttgcgaa caaaactgat    1260

gatctgctag gggatcttcc tcaagctatc gagagagtaa tctgtcttac taatgacgaa    1320

atgaagcgtt gggcggatga aatttgtact gccaaaagtg ccatcttctt agggagagga    1380

ctgaacgcac ctgtagcatt tgagggcgcg ctaaagttga aggaaatctc atatatccat    1440

gccgagggtt tcctcggtgg agagttgaag catgggccgc tggctttgtt ggacgataag    1500

atccctgtaa tcgtgactgt tgctgaccac gcttatttgg atcacattaa ggctaacatc    1560

gacgaggtat tggcacgaaa cgttaccgta tacgcgatcg tcgatcagta tgttaatatt    1620

gaaccacagg agcgactgca tgtagtaaaa gtgccgtttg tgagtaaaga gttttctccc    1680

atcatccaca caattccgat gcaattgtta tcgtattatg tcgcgatcaa gctgggcaag    1740

aacgttgaca agccacgtaa cctggcgaaa agtgttacaa cattctaa                 1788


<210> 74
<211> 1788
<212> DNA
<213> Chlorella virus


<220> 
<223> reencoded nucleic acid sequence of glutamine-fructose-6-phosphate
      amidotransferase (GFA1) originating from Chlorella virus 1
      (PBCV-1)

<400> 74
atgtgtggca tctttggagc agtgtcaaac aacaactcta tcgaggtgtc aatcaagggt      60

attcagaagc tagaatatcg tgggtatgat tcgtgcggta ttgcgtatac agatgggggt     120

gcgattgagc gtatacgttc tattgacggc attgacgatc tgcgtaagaa aacaatcaca     180

gaatcatcac cagtggccat tgctcactcg cggtggagca ccactggaat tccatcagtg     240

gtgaacgcac atcctcatat ttctcgcgga accagtgggt gtgagtctcg tatcgcggta     300

gtccacaacg gtatcattga aaactatcag cagatccgaa aatatctcat caatcttggt     360

tatacgtttg atagtcaaac ggacacagag gtcattgcgc atttgattga ttctcagtac     420

aatgggaata tcttgcacac cgtccaaatg gctgtcaagc acctgaaggg ctcttatgcc     480

attgcagtta tgtgtcataa agagtctggt aaaatagtcg tggcgaaaca gaagtcaccc     540

ctcgtacttg gaatcggctc agatggtgct tactacatcg cttcggacgt gctggcgctg     600

ccgacaaata aagttgttta tatttcagac ggtttctccg cagaactatc tccagggagt     660

atgaccattt acgatcttga tggaaataaa gtagaatatg aagtagagga cgttgaaatg     720

gaacaaacta gtatgtctct cgataacttt gatcattaca tgattaagga aattaatgag     780

caaccaatca gtattctaaa cactataaaa aataaagggt tctatgcaga aatattcggt     840

gatttggctc atgaaatctt ccaaaaaata gacaacatcc tgatactggc ttgtggtaca     900

agttatcacg ccggtcttgt aggaaaacag tggatagaga ccatctctag aatccccgtg     960

gatgttcaca tcgcgagtga atacgaacct actattccga gagcgaacac attggtaatc    1020

actatttcac agtcgggtga aactgcggac acgatagcgg ctttgcaacg ggcccaaaac    1080

gccgggatga tttatacatt gtgtatttgc aattcaccaa agagcactct tgttcgtgag    1140

agcattatga agtacatcac gaaatgtggt tctgaggtgt cagtggcatc aacgaaggcg    1200

tttacttctc agctcgtagt actgtacatg ctggcaaacg tattggcaaa taaaaccgat    1260

gatttgctgg gagacctccc acaggcaata gaacgggtaa tttgtttgac aaatgacgaa    1320

atgaaacgat gggccgacga aatttgcact gcgaaatccg cgatcttcct gggaagagga    1380

ctaaacgcac cagttgcctt tgagggagcg ttgaagctca aagaaatctc ttacattcat    1440

gcagagggct tcctgggagg tgagttgaaa cacggccccc tcgcactcct tgatgacaag    1500

attcctgtta tcgtaaccgt agcagatcat gcttatttgg accatatcaa agcaaatatc    1560

gacgaagtgc ttgcgaggaa cgttacggta tacgccatag tagaccagta tgtgaacatc    1620

gagccccagg aacgccttca cgtcgtcaag gttccgtttg tatccaaaga attttctccg    1680

ataattcaca ctatcccgat gcaactgctt tcgtattacg tggcaattaa gcttggaaag    1740

aacgttgaca aaccaaggaa tcttgcaaaa tccgtgacta ccttttaa                 1788


<210> 75
<211> 717
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> amino acid sequence of glutamine-fructose-6-phosphate
      amidotransferase (GFA1) originating from Saccharomyces cerevisiae

<400> 75
Met Cys Gly Ile Phe Gly Tyr Cys Asn Tyr Leu Val Glu Arg Ser Arg 
1               5                   10                  15      
Gly Glu Ile Ile Asp Thr Leu Val Asp Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          
Arg Gly Tyr Asp Ser Thr Gly Ile Ala Ile Asp Gly Asp Glu Ala Asp 
        35                  40                  45              
Ser Thr Phe Ile Tyr Lys Gln Ile Gly Lys Val Ser Ala Leu Lys Glu 
    50                  55                  60                  
Glu Ile Thr Lys Gln Asn Pro Asn Arg Asp Val Thr Phe Val Ser His 
65                  70                  75                  80  
Cys Gly Ile Ala His Thr Arg Trp Ala Thr His Gly Arg Pro Glu Gln 
                85                  90                  95      
Val Asn Cys His Pro Gln Arg Ser Asp Pro Glu Asp Gln Phe Val Val 
            100                 105                 110         
Val His Asn Gly Ile Ile Thr Asn Phe Arg Glu Leu Lys Thr Leu Leu 
        115                 120                 125             
Ile Asn Lys Gly Tyr Lys Phe Glu Ser Asp Thr Asp Thr Glu Cys Ile 
    130                 135                 140                 
Ala Lys Leu Tyr Leu His Leu Tyr Asn Thr Asn Leu Gln Asn Gly His 
145                 150                 155                 160 
Asp Leu Asp Phe His Glu Leu Thr Lys Leu Val Leu Leu Glu Leu Glu 
                165                 170                 175     
Gly Ser Tyr Gly Leu Leu Cys Lys Ser Cys His Tyr Pro Asn Glu Val 
            180                 185                 190         
Ile Ala Thr Arg Lys Gly Ser Pro Leu Leu Ile Gly Val Lys Ser Glu 
        195                 200                 205             
Lys Lys Leu Lys Val Asp Phe Val Asp Val Glu Phe Pro Glu Glu Asn 
    210                 215                 220                 
Ala Gly Gln Pro Glu Ile Pro Leu Lys Ser Asn Asn Lys Ser Phe Gly 
225                 230                 235                 240 
Leu Gly Pro Lys Lys Ala Arg Glu Phe Glu Ala Gly Ser Gln Asn Ala 
                245                 250                 255     
Asn Leu Leu Pro Ile Ala Ala Asn Glu Phe Asn Leu Arg His Ser Gln 
            260                 265                 270         
Ser Arg Ala Phe Leu Ser Glu Asp Gly Ser Pro Thr Pro Val Glu Phe 
        275                 280                 285             
Phe Val Ser Ser Asp Ala Ala Ser Val Val Lys His Thr Lys Lys Val 
    290                 295                 300                 
Leu Phe Leu Glu Asp Asp Asp Leu Ala His Ile Tyr Asp Gly Glu Leu 
305                 310                 315                 320 
His Ile His Arg Ser Arg Arg Glu Val Gly Ala Ser Met Thr Arg Ser 
                325                 330                 335     
Ile Gln Thr Leu Glu Met Glu Leu Ala Gln Ile Met Lys Gly Pro Tyr 
            340                 345                 350         
Asp His Phe Met Gln Lys Glu Ile Tyr Glu Gln Pro Glu Ser Thr Phe 
        355                 360                 365             
Asn Thr Met Arg Gly Arg Ile Asp Tyr Glu Asn Asn Lys Val Ile Leu 
    370                 375                 380                 
Gly Gly Leu Lys Ala Trp Leu Pro Val Val Arg Arg Ala Arg Arg Leu 
385                 390                 395                 400 
Ile Met Ile Ala Cys Gly Thr Ser Tyr His Ser Cys Leu Ala Thr Arg 
                405                 410                 415     
Ala Ile Phe Glu Glu Leu Ser Asp Ile Pro Val Ser Val Glu Leu Ala 
            420                 425                 430         
Ser Asp Phe Leu Asp Arg Lys Cys Pro Val Phe Arg Asp Asp Val Cys 
        435                 440                 445             
Val Phe Val Ser Gln Ser Gly Glu Thr Ala Asp Thr Met Leu Ala Leu 
    450                 455                 460                 
Asn Tyr Cys Leu Glu Arg Gly Ala Leu Thr Val Gly Ile Val Asn Ser 
465                 470                 475                 480 
Val Gly Ser Ser Ile Ser Arg Val Thr His Cys Gly Val His Ile Asn 
                485                 490                 495     
Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr Thr Ser Gln 
            500                 505                 510         
Tyr Ile Ala Leu Val Met Phe Ala Leu Ser Leu Ser Asp Asp Arg Val 
        515                 520                 525             
Ser Lys Ile Asp Arg Arg Ile Glu Ile Ile Gln Gly Leu Lys Leu Ile 
    530                 535                 540                 
Pro Gly Gln Ile Lys Gln Val Leu Lys Leu Glu Pro Arg Ile Lys Lys 
545                 550                 555                 560 
Leu Cys Ala Thr Glu Leu Lys Asp Gln Lys Ser Leu Leu Leu Leu Gly 
                565                 570                 575     
Arg Gly Tyr Gln Phe Ala Ala Ala Leu Glu Gly Ala Leu Lys Ile Lys 
            580                 585                 590         
Glu Ile Ser Tyr Met His Ser Glu Gly Val Leu Ala Gly Glu Leu Lys 
        595                 600                 605             
His Gly Val Leu Ala Leu Val Asp Glu Asn Leu Pro Ile Ile Ala Phe 
    610                 615                 620                 
Gly Thr Arg Asp Ser Leu Phe Pro Lys Val Val Ser Ser Ile Glu Gln 
625                 630                 635                 640 
Val Thr Ala Arg Lys Gly His Pro Ile Ile Ile Cys Asn Glu Asn Asp 
                645                 650                 655     
Glu Val Trp Ala Gln Lys Ser Lys Ser Ile Asp Leu Gln Thr Leu Glu 
            660                 665                 670         
Val Pro Gln Thr Val Asp Cys Leu Gln Gly Leu Ile Asn Ile Ile Pro 
        675                 680                 685             
Leu Gln Leu Met Ser Tyr Trp Leu Ala Val Asn Lys Gly Ile Asp Val 
    690                 695                 700                 
Asp Phe Pro Arg Asn Leu Ala Lys Ser Val Thr Val Glu 
705                 710                 715         

<210> 76
<211> 595
<212> PRT
<213> Chlorella virus


<220> 
<223> amino acid sequence of glutamine-fructose-6-phosphate
      amidotransferase (GFA1) originating from Chlorella virus 1
      (PBCV-1)

<400> 76
Met Cys Gly Ile Phe Gly Ala Val Ser Asn Asn Asn Ser Ile Glu Val 
1               5                   10                  15      
Ser Ile Lys Gly Ile Gln Lys Leu Glu Tyr Arg Gly Tyr Asp Ser Cys 
            20                  25                  30          
Gly Ile Ala Tyr Thr Asp Gly Gly Ala Ile Glu Arg Ile Arg Ser Ile 
        35                  40                  45              
Asp Gly Ile Asp Asp Leu Arg Lys Lys Thr Ile Thr Glu Ser Ser Pro 
    50                  55                  60                  
Val Ala Ile Ala His Ser Arg Trp Ser Thr Thr Gly Ile Pro Ser Val 
65                  70                  75                  80  
Val Asn Ala His Pro His Ile Ser Arg Gly Thr Ser Gly Cys Glu Ser 
                85                  90                  95      
Arg Ile Ala Val Val His Asn Gly Ile Ile Glu Asn Tyr Gln Gln Ile 
            100                 105                 110         
Arg Lys Tyr Leu Ile Asn Leu Gly Tyr Thr Phe Asp Ser Gln Thr Asp 
        115                 120                 125             
Thr Glu Val Ile Ala His Leu Ile Asp Ser Gln Tyr Asn Gly Asn Ile 
    130                 135                 140                 
Leu His Thr Val Gln Met Ala Val Lys His Leu Lys Gly Ser Tyr Ala 
145                 150                 155                 160 
Ile Ala Val Met Cys His Lys Glu Ser Gly Lys Ile Val Val Ala Lys 
                165                 170                 175     
Gln Lys Ser Pro Leu Val Leu Gly Ile Gly Ser Asp Gly Ala Tyr Tyr 
            180                 185                 190         
Ile Ala Ser Asp Val Leu Ala Leu Pro Thr Asn Lys Val Val Tyr Ile 
        195                 200                 205             
Ser Asp Gly Phe Ser Ala Glu Leu Ser Pro Gly Ser Met Thr Ile Tyr 
    210                 215                 220                 
Asp Leu Asp Gly Asn Lys Val Glu Tyr Glu Val Glu Asp Val Glu Met 
225                 230                 235                 240 
Glu Gln Thr Ser Met Ser Leu Asp Asn Phe Asp His Tyr Met Ile Lys 
                245                 250                 255     
Glu Ile Asn Glu Gln Pro Ile Ser Ile Leu Asn Thr Ile Lys Asn Lys 
            260                 265                 270         
Gly Phe Tyr Ala Glu Ile Phe Gly Asp Leu Ala His Glu Ile Phe Gln 
        275                 280                 285             
Lys Ile Asp Asn Ile Leu Ile Leu Ala Cys Gly Thr Ser Tyr His Ala 
    290                 295                 300                 
Gly Leu Val Gly Lys Gln Trp Ile Glu Thr Ile Ser Arg Ile Pro Val 
305                 310                 315                 320 
Asp Val His Ile Ala Ser Glu Tyr Glu Pro Thr Ile Pro Arg Ala Asn 
                325                 330                 335     
Thr Leu Val Ile Thr Ile Ser Gln Ser Gly Glu Thr Ala Asp Thr Ile 
            340                 345                 350         
Ala Ala Leu Gln Arg Ala Gln Asn Ala Gly Met Ile Tyr Thr Leu Cys 
        355                 360                 365             
Ile Cys Asn Ser Pro Lys Ser Thr Leu Val Arg Glu Ser Ile Met Lys 
    370                 375                 380                 
Tyr Ile Thr Lys Cys Gly Ser Glu Val Ser Val Ala Ser Thr Lys Ala 
385                 390                 395                 400 
Phe Thr Ser Gln Leu Val Val Leu Tyr Met Leu Ala Asn Val Leu Ala 
                405                 410                 415     
Asn Lys Thr Asp Asp Leu Leu Gly Asp Leu Pro Gln Ala Ile Glu Arg 
            420                 425                 430         
Val Ile Cys Leu Thr Asn Asp Glu Met Lys Arg Trp Ala Asp Glu Ile 
        435                 440                 445             
Cys Thr Ala Lys Ser Ala Ile Phe Leu Gly Arg Gly Leu Asn Ala Pro 
    450                 455                 460                 
Val Ala Phe Glu Gly Ala Leu Lys Leu Lys Glu Ile Ser Tyr Ile His 
465                 470                 475                 480 
Ala Glu Gly Phe Leu Gly Gly Glu Leu Lys His Gly Pro Leu Ala Leu 
                485                 490                 495     
Leu Asp Asp Lys Ile Pro Val Ile Val Thr Val Ala Asp His Ala Tyr 
            500                 505                 510         
Leu Asp His Ile Lys Ala Asn Ile Asp Glu Val Leu Ala Arg Asn Val 
        515                 520                 525             
Thr Val Tyr Ala Ile Val Asp Gln Tyr Val Asn Ile Glu Pro Gln Glu 
    530                 535                 540                 
Arg Leu His Val Val Lys Val Pro Phe Val Ser Lys Glu Phe Ser Pro 
545                 550                 555                 560 
Ile Ile His Thr Ile Pro Met Gln Leu Leu Ser Tyr Tyr Val Ala Ile 
                565                 570                 575     
Lys Leu Gly Lys Asn Val Asp Lys Pro Arg Asn Leu Ala Lys Ser Val 
            580                 585                 590         
Thr Thr Phe 
        595 

<210> 77
<211> 1434
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> nucleic acid sequence of UDP-N-acetylglucosamine
      pyrophosphorylase (QRI1) originating from Saccharomyces
      cerevisiae

<400> 77
atgactgaca caaaacagct attcattgaa gccggacaaa gtcaactttt ccacaattgg      60

gaaagcttgt ctcgcaaaga ccaagaagaa ttgctttcaa acctggagca aatatcttcc     120

aagaggtccc ctgcaaaact actggaagac tgtcaaaatg ctattaaatt ctcactagct     180

aactcttcta aggatactgg cgtcgaaatt tcaccattgc cccctacttc gtacgagtcg     240

cttattggca acagtaagaa agaaaatgaa tactggcgtt taggccttga agctattggc     300

aagggtgaag tcgcagtgat tttaatggct ggcggacaag gtacgcggtt aggatcctct     360

caaccaaagg gctgttacga cattggattg ccttctaaga aatctctttt tcaaattcaa     420

gctgaaaagt tgatcaggtt gcaagatatg gtaaaggaca aaaaggtaga aattccttgg     480

tatattatga catcaggccc cactagagcg gctactgagg catactttca agaacacaat     540

tattttggct tgaataaaga acaaattacg ttcttcaacc agggaaccct gcctgccttt     600

gatttaaccg ggaagcattt cctaatgaaa gacccagtaa acctatctca atcaccagat     660

ggaaatggtg gactctaccg tgccatcaag gaaaacaagt tgaacgaaga ctttgatagg     720

agaggaatca agcatgttta catgtactgt gtcgataatg tcctatctaa aatcgcagac     780

cctgtattta ttggttttgc catcaagcat ggcttcgaac tggccaccaa agccgttaga     840

aagagagatg cgcatgaatc agttgggtta attgctacta aaaacgagaa accatgtgtc     900

atagaatatt ctgaaatttc caatgaattg gctgaagcaa aggataaaga tggcttatta     960

aaactacgcg caggcaacat tgtaaatcat tattacctag tggatttact aaaacgtgat    1020

ttggatcagt ggtgtgagaa tatgccatat cacattgcga agaagaaaat tccagcttat    1080

gatagtgtta ccggcaagta cactaagcct accgaaccaa acggtataaa attagagcaa    1140

ttcatatttg atgtctttga cactgtacca ctgaacaagt ttgggtgctt agaagtagat    1200

agatgcaaag aattttcacc tttaaaaaac ggtcctggtt ctaagaacga taatcctgag    1260

accagcagac tagcatattt gaaactagga acctcgtggt tggaagatgc aggcgctatt    1320

gtaaaagatg gggtactagt cgaagtttcc agcaaattga gttatgcagg tgaaaatcta    1380

tcccagttca aaggtaaagt ctttgacaga agtggtatag tattagaaaa ataa          1434


<210> 78
<211> 477
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> amino acid sequence of UDP-N-acetylglucosamine pyrophosphorylase
      (QRI1) originating from Saccharomyces cerevisiae

<400> 78
Met Thr Asp Thr Lys Gln Leu Phe Ile Glu Ala Gly Gln Ser Gln Leu 
1               5                   10                  15      
Phe His Asn Trp Glu Ser Leu Ser Arg Lys Asp Gln Glu Glu Leu Leu 
            20                  25                  30          
Ser Asn Leu Glu Gln Ile Ser Ser Lys Arg Ser Pro Ala Lys Leu Leu 
        35                  40                  45              
Glu Asp Cys Gln Asn Ala Ile Lys Phe Ser Leu Ala Asn Ser Ser Lys 
    50                  55                  60                  
Asp Thr Gly Val Glu Ile Ser Pro Leu Pro Pro Thr Ser Tyr Glu Ser 
65                  70                  75                  80  
Leu Ile Gly Asn Ser Lys Lys Glu Asn Glu Tyr Trp Arg Leu Gly Leu 
                85                  90                  95      
Glu Ala Ile Gly Lys Gly Glu Val Ala Val Ile Leu Met Ala Gly Gly 
            100                 105                 110         
Gln Gly Thr Arg Leu Gly Ser Ser Gln Pro Lys Gly Cys Tyr Asp Ile 
        115                 120                 125             
Gly Leu Pro Ser Lys Lys Ser Leu Phe Gln Ile Gln Ala Glu Lys Leu 
    130                 135                 140                 
Ile Arg Leu Gln Asp Met Val Lys Asp Lys Lys Val Glu Ile Pro Trp 
145                 150                 155                 160 
Tyr Ile Met Thr Ser Gly Pro Thr Arg Ala Ala Thr Glu Ala Tyr Phe 
                165                 170                 175     
Gln Glu His Asn Tyr Phe Gly Leu Asn Lys Glu Gln Ile Thr Phe Phe 
            180                 185                 190         
Asn Gln Gly Thr Leu Pro Ala Phe Asp Leu Thr Gly Lys His Phe Leu 
        195                 200                 205             
Met Lys Asp Pro Val Asn Leu Ser Gln Ser Pro Asp Gly Asn Gly Gly 
    210                 215                 220                 
Leu Tyr Arg Ala Ile Lys Glu Asn Lys Leu Asn Glu Asp Phe Asp Arg 
225                 230                 235                 240 
Arg Gly Ile Lys His Val Tyr Met Tyr Cys Val Asp Asn Val Leu Ser 
                245                 250                 255     
Lys Ile Ala Asp Pro Val Phe Ile Gly Phe Ala Ile Lys His Gly Phe 
            260                 265                 270         
Glu Leu Ala Thr Lys Ala Val Arg Lys Arg Asp Ala His Glu Ser Val 
        275                 280                 285             
Gly Leu Ile Ala Thr Lys Asn Glu Lys Pro Cys Val Ile Glu Tyr Ser 
    290                 295                 300                 
Glu Ile Ser Asn Glu Leu Ala Glu Ala Lys Asp Lys Asp Gly Leu Leu 
305                 310                 315                 320 
Lys Leu Arg Ala Gly Asn Ile Val Asn His Tyr Tyr Leu Val Asp Leu 
                325                 330                 335     
Leu Lys Arg Asp Leu Asp Gln Trp Cys Glu Asn Met Pro Tyr His Ile 
            340                 345                 350         
Ala Lys Lys Lys Ile Pro Ala Tyr Asp Ser Val Thr Gly Lys Tyr Thr 
        355                 360                 365             
Lys Pro Thr Glu Pro Asn Gly Ile Lys Leu Glu Gln Phe Ile Phe Asp 
    370                 375                 380                 
Val Phe Asp Thr Val Pro Leu Asn Lys Phe Gly Cys Leu Glu Val Asp 
385                 390                 395                 400 
Arg Cys Lys Glu Phe Ser Pro Leu Lys Asn Gly Pro Gly Ser Lys Asn 
                405                 410                 415     
Asp Asn Pro Glu Thr Ser Arg Leu Ala Tyr Leu Lys Leu Gly Thr Ser 
            420                 425                 430         
Trp Leu Glu Asp Ala Gly Ala Ile Val Lys Asp Gly Val Leu Val Glu 
        435                 440                 445             
Val Ser Ser Lys Leu Ser Tyr Ala Gly Glu Asn Leu Ser Gln Phe Lys 
    450                 455                 460                 
Gly Lys Val Phe Asp Arg Ser Gly Ile Val Leu Glu Lys 
465                 470                 475         

<210> 79
<211> 1713
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> nucleic acid sequence of Phosphoglucomutase-1 (PGM1) originating
      from Saccharomyces cerevisiae

<400> 79
atgtcacttc taatagattc tgtaccaaca gttgcttata aggaccaaaa accgggtact      60

tcaggtttac gtaagaagac caaggttttc atggatgagc ctcattatac tgagaacttc     120

attcaagcaa caatgcaatc tatccctaat ggctcagagg gaaccacttt agttgttgga     180

ggagatggtc gtttctacaa cgatgttatc atgaacaaga ttgccgcagt aggtgctgca     240

aacggtgtca gaaagttagt cattggtcaa ggcggtttac tttcaacacc agctgcttct     300

catataatta gaacatacga ggaaaagtgt accggtggtg gtatcatatt aactgcctca     360

cacaacccag gcggtccaga gaatgattta ggtatcaagt ataatttacc taatggtggg     420

ccagctccag agagtgtcac taacgctatc tgggaagcgt ctaaaaaatt aactcactat     480

aaaattataa agaacttccc caagttgaat ttgaacaagc ttggtaaaaa ccaaaaatat     540

ggcccattgt tagtggacat aattgatcct gccaaagcat acgttcaatt tctgaaggaa     600

atttttgatt ttgacttaat taaaagcttc ttagcgaaac agcgcaaaga caaagggtgg     660

aagttgttgt ttgactcctt aaatggtatt acaggaccat atggtaaggc tatatttgtt     720

gatgaatttg gtttaccggc agaggaagtt cttcaaaatt ggcacccttt acctgatttc     780

ggcggtttac atcccgatcc gaatctaacc tatgcacgaa ctcttgttga cagggttgac     840

cgcgaaaaaa ttgcctttgg agcagcctcc gatggtgatg gtgataggaa tatgatttac     900

ggttatggcc ctgctttcgt ttcgccaggt gattctgttg ccattattgc cgaatatgca     960

cccgaaattc catacttcgc caaacaaggt atttatggct tggcacgttc atttcctaca    1020

tcctcagcca ttgatcgtgt tgcagcaaaa aagggattaa gatgttacga agttccaacc    1080

ggctggaaat tcttctgtgc cttatttgat gctaaaaagc tatcaatctg tggtgaagaa    1140

tccttcggta caggttccaa tcatatcaga gaaaaggacg gtctatgggc cattattgct    1200

tggttaaata tcttggctat ctaccatagg cgtaaccctg aaaaggaagc ttcgatcaaa    1260

actattcagg acgaattttg gaacgagtat ggccgtactt tcttcacaag atacgattac    1320

gaacatatcg aatgcgagca ggccgaaaaa gttgtagctc ttttgagtga atttgtatca    1380

aggccaaacg tttgtggctc ccacttccca gctgatgagt ctttaaccgt tatcgattgt    1440

ggtgattttt cgtatagaga tctagatggc tccatctctg aaaatcaagg ccttttcgta    1500

aagttttcga atgggactaa atttgttttg aggttatccg gcacaggcag ttctggtgca    1560

acaataagat tatacgtaga aaagtatact gataaaaagg agaactatgg ccaaacagct    1620

gacgtcttct tgaaacccgt catcaactcc attgtaaaat tcttaagatt taaagaaatt    1680

ttaggaacag acgaaccaac agtccgcaca tag                                 1713


<210> 80
<211> 570
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> amino acid sequence Phosphoglucomutase-1 (PGM1) originating from
      Saccharomyces cerevisiae

<400> 80
Met Ser Leu Leu Ile Asp Ser Val Pro Thr Val Ala Tyr Lys Asp Gln 
1               5                   10                  15      
Lys Pro Gly Thr Ser Gly Leu Arg Lys Lys Thr Lys Val Phe Met Asp 
            20                  25                  30          
Glu Pro His Tyr Thr Glu Asn Phe Ile Gln Ala Thr Met Gln Ser Ile 
        35                  40                  45              
Pro Asn Gly Ser Glu Gly Thr Thr Leu Val Val Gly Gly Asp Gly Arg 
    50                  55                  60                  
Phe Tyr Asn Asp Val Ile Met Asn Lys Ile Ala Ala Val Gly Ala Ala 
65                  70                  75                  80  
Asn Gly Val Arg Lys Leu Val Ile Gly Gln Gly Gly Leu Leu Ser Thr 
                85                  90                  95      
Pro Ala Ala Ser His Ile Ile Arg Thr Tyr Glu Glu Lys Cys Thr Gly 
            100                 105                 110         
Gly Gly Ile Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Glu Asn 
        115                 120                 125             
Asp Leu Gly Ile Lys Tyr Asn Leu Pro Asn Gly Gly Pro Ala Pro Glu 
    130                 135                 140                 
Ser Val Thr Asn Ala Ile Trp Glu Ala Ser Lys Lys Leu Thr His Tyr 
145                 150                 155                 160 
Lys Ile Ile Lys Asn Phe Pro Lys Leu Asn Leu Asn Lys Leu Gly Lys 
                165                 170                 175     
Asn Gln Lys Tyr Gly Pro Leu Leu Val Asp Ile Ile Asp Pro Ala Lys 
            180                 185                 190         
Ala Tyr Val Gln Phe Leu Lys Glu Ile Phe Asp Phe Asp Leu Ile Lys 
        195                 200                 205             
Ser Phe Leu Ala Lys Gln Arg Lys Asp Lys Gly Trp Lys Leu Leu Phe 
    210                 215                 220                 
Asp Ser Leu Asn Gly Ile Thr Gly Pro Tyr Gly Lys Ala Ile Phe Val 
225                 230                 235                 240 
Asp Glu Phe Gly Leu Pro Ala Glu Glu Val Leu Gln Asn Trp His Pro 
                245                 250                 255     
Leu Pro Asp Phe Gly Gly Leu His Pro Asp Pro Asn Leu Thr Tyr Ala 
            260                 265                 270         
Arg Thr Leu Val Asp Arg Val Asp Arg Glu Lys Ile Ala Phe Gly Ala 
        275                 280                 285             
Ala Ser Asp Gly Asp Gly Asp Arg Asn Met Ile Tyr Gly Tyr Gly Pro 
    290                 295                 300                 
Ala Phe Val Ser Pro Gly Asp Ser Val Ala Ile Ile Ala Glu Tyr Ala 
305                 310                 315                 320 
Pro Glu Ile Pro Tyr Phe Ala Lys Gln Gly Ile Tyr Gly Leu Ala Arg 
                325                 330                 335     
Ser Phe Pro Thr Ser Ser Ala Ile Asp Arg Val Ala Ala Lys Lys Gly 
            340                 345                 350         
Leu Arg Cys Tyr Glu Val Pro Thr Gly Trp Lys Phe Phe Cys Ala Leu 
        355                 360                 365             
Phe Asp Ala Lys Lys Leu Ser Ile Cys Gly Glu Glu Ser Phe Gly Thr 
    370                 375                 380                 
Gly Ser Asn His Ile Arg Glu Lys Asp Gly Leu Trp Ala Ile Ile Ala 
385                 390                 395                 400 
Trp Leu Asn Ile Leu Ala Ile Tyr His Arg Arg Asn Pro Glu Lys Glu 
                405                 410                 415     
Ala Ser Ile Lys Thr Ile Gln Asp Glu Phe Trp Asn Glu Tyr Gly Arg 
            420                 425                 430         
Thr Phe Phe Thr Arg Tyr Asp Tyr Glu His Ile Glu Cys Glu Gln Ala 
        435                 440                 445             
Glu Lys Val Val Ala Leu Leu Ser Glu Phe Val Ser Arg Pro Asn Val 
    450                 455                 460                 
Cys Gly Ser His Phe Pro Ala Asp Glu Ser Leu Thr Val Ile Asp Cys 
465                 470                 475                 480 
Gly Asp Phe Ser Tyr Arg Asp Leu Asp Gly Ser Ile Ser Glu Asn Gln 
                485                 490                 495     
Gly Leu Phe Val Lys Phe Ser Asn Gly Thr Lys Phe Val Leu Arg Leu 
            500                 505                 510         
Ser Gly Thr Gly Ser Ser Gly Ala Thr Ile Arg Leu Tyr Val Glu Lys 
        515                 520                 525             
Tyr Thr Asp Lys Lys Glu Asn Tyr Gly Gln Thr Ala Asp Val Phe Leu 
    530                 535                 540                 
Lys Pro Val Ile Asn Ser Ile Val Lys Phe Leu Arg Phe Lys Glu Ile 
545                 550                 555                 560 
Leu Gly Thr Asp Glu Pro Thr Val Arg Thr 
                565                 570 

<210> 81
<211> 1500
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> nucleic acid sequence of UTP-glucose-1-phosphate
      uridylyltransferase (UGP1) originating from Saccharomyces
      cerevisiae

<400> 81
atgtccacta agaagcacac caaaacacat tccacttatg cattcgagag caacacaaac      60

agcgttgctg cctcacaaat gagaaacgcc ttaaacaagt tggcggactc tagtaaactt     120

gacgatgctg ctcgcgctaa gtttgagaac gaactggatt cgtttttcac gcttttcagg     180

agatatttgg tagagaagtc ttctagaacc accttggaat gggacaagat caagtctccc     240

aacccggatg aagtggttaa gtatgaaatt atttctcagc agcccgagaa tgtctcaaac     300

ctttccaaat tggctgtttt gaagttgaac ggtgggctgg gtacctccat gggctgcgtt     360

ggccctaaat ctgttattga agtgagagag ggaaacacct ttttggattt gtctgttcgt     420

caaattgaat acttgaacag acagtacgat agcgacgtgc cattgttatt gatgaattct     480

ttcaacactg acaaggatac ggaacacttg attaagaagt attccgctaa cagaatcaga     540

atcagatctt tcaatcaatc caggttccca agagtctaca aggattcttt attgcctgtc     600

cccaccgaat acgattctcc actggatgct tggtatccac caggtcacgg tgatttgttt     660

gaatctttac acgtatctgg tgaactggat gccttaattg cccaaggaag agaaatatta     720

tttgtttcta acggtgacaa cttgggtgct accgtcgact taaaaatttt aaaccacatg     780

atcgagactg gtgccgaata tataatggaa ttgactgata agaccagagc cgatgttaaa     840

ggtggtactt tgatttctta cgatggtcaa gtccgtttat tggaagtcgc ccaagttcca     900

aaagaacaca ttgacgaatt caaaaatatc agaaagttta ccaacttcaa cacgaataac     960

ttatggatca atctgaaagc agtaaagagg ttgatcgaat cgagcaattt ggagatggaa    1020

atcattccaa accaaaaaac tataacaaga gacggtcatg aaattaatgt cttacaatta    1080

gaaaccgctt gtggtgctgc tatcaggcat tttgatggtg ctcacggtgt tgtcgttcca    1140

agatcaagat tcttgcctgt caagacctgt tccgatttgt tgctggttaa atcagatcta    1200

ttccgtctgg aacacggttc tttgaagtta gacccatccc gttttggtcc aaacccatta    1260

atcaagttgg gctcgcattt caaaaaggtt tctggtttta acgcaagaat ccctcacatc    1320

ccaaaaatcg tcgagctaga tcatttgacc atcactggta acgtcttttt aggtaaagat    1380

gtcactttga ggggtactgt catcatcgtt tgctccgacg gtcataaaat cgatattcca    1440

aacggctcca tattggaaaa tgttgtcgtt actggtaatt tgcaaatctt ggaacattga    1500


<210> 82
<211> 499
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> amino acid sequence of UTP--glucose-1-phosphate
      uridylyltransferase (UGP1) originating from Saccharomyces
      cerevisiae

<400> 82
Met Ser Thr Lys Lys His Thr Lys Thr His Ser Thr Tyr Ala Phe Glu 
1               5                   10                  15      
Ser Asn Thr Asn Ser Val Ala Ala Ser Gln Met Arg Asn Ala Leu Asn 
            20                  25                  30          
Lys Leu Ala Asp Ser Ser Lys Leu Asp Asp Ala Ala Arg Ala Lys Phe 
        35                  40                  45              
Glu Asn Glu Leu Asp Ser Phe Phe Thr Leu Phe Arg Arg Tyr Leu Val 
    50                  55                  60                  
Glu Lys Ser Ser Arg Thr Thr Leu Glu Trp Asp Lys Ile Lys Ser Pro 
65                  70                  75                  80  
Asn Pro Asp Glu Val Val Lys Tyr Glu Ile Ile Ser Gln Gln Pro Glu 
                85                  90                  95      
Asn Val Ser Asn Leu Ser Lys Leu Ala Val Leu Lys Leu Asn Gly Gly 
            100                 105                 110         
Leu Gly Thr Ser Met Gly Cys Val Gly Pro Lys Ser Val Ile Glu Val 
        115                 120                 125             
Arg Glu Gly Asn Thr Phe Leu Asp Leu Ser Val Arg Gln Ile Glu Tyr 
    130                 135                 140                 
Leu Asn Arg Gln Tyr Asp Ser Asp Val Pro Leu Leu Leu Met Asn Ser 
145                 150                 155                 160 
Phe Asn Thr Asp Lys Asp Thr Glu His Leu Ile Lys Lys Tyr Ser Ala 
                165                 170                 175     
Asn Arg Ile Arg Ile Arg Ser Phe Asn Gln Ser Arg Phe Pro Arg Val 
            180                 185                 190         
Tyr Lys Asp Ser Leu Leu Pro Val Pro Thr Glu Tyr Asp Ser Pro Leu 
        195                 200                 205             
Asp Ala Trp Tyr Pro Pro Gly His Gly Asp Leu Phe Glu Ser Leu His 
    210                 215                 220                 
Val Ser Gly Glu Leu Asp Ala Leu Ile Ala Gln Gly Arg Glu Ile Leu 
225                 230                 235                 240 
Phe Val Ser Asn Gly Asp Asn Leu Gly Ala Thr Val Asp Leu Lys Ile 
                245                 250                 255     
Leu Asn His Met Ile Glu Thr Gly Ala Glu Tyr Ile Met Glu Leu Thr 
            260                 265                 270         
Asp Lys Thr Arg Ala Asp Val Lys Gly Gly Thr Leu Ile Ser Tyr Asp 
        275                 280                 285             
Gly Gln Val Arg Leu Leu Glu Val Ala Gln Val Pro Lys Glu His Ile 
    290                 295                 300                 
Asp Glu Phe Lys Asn Ile Arg Lys Phe Thr Asn Phe Asn Thr Asn Asn 
305                 310                 315                 320 
Leu Trp Ile Asn Leu Lys Ala Val Lys Arg Leu Ile Glu Ser Ser Asn 
                325                 330                 335     
Leu Glu Met Glu Ile Ile Pro Asn Gln Lys Thr Ile Thr Arg Asp Gly 
            340                 345                 350         
His Glu Ile Asn Val Leu Gln Leu Glu Thr Ala Cys Gly Ala Ala Ile 
        355                 360                 365             
Arg His Phe Asp Gly Ala His Gly Val Val Val Pro Arg Ser Arg Phe 
    370                 375                 380                 
Leu Pro Val Lys Thr Cys Ser Asp Leu Leu Leu Val Lys Ser Asp Leu 
385                 390                 395                 400 
Phe Arg Leu Glu His Gly Ser Leu Lys Leu Asp Pro Ser Arg Phe Gly 
                405                 410                 415     
Pro Asn Pro Leu Ile Lys Leu Gly Ser His Phe Lys Lys Val Ser Gly 
            420                 425                 430         
Phe Asn Ala Arg Ile Pro His Ile Pro Lys Ile Val Glu Leu Asp His 
        435                 440                 445             
Leu Thr Ile Thr Gly Asn Val Phe Leu Gly Lys Asp Val Thr Leu Arg 
    450                 455                 460                 
Gly Thr Val Ile Ile Val Cys Ser Asp Gly His Lys Ile Asp Ile Pro 
465                 470                 475                 480 
Asn Gly Ser Ile Leu Glu Asn Val Val Val Thr Gly Asn Leu Gln Ile 
                485                 490                 495     
Leu Glu His 
            

<210> 83
<211> 480
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> nucleic acid sequence of Glucosamine 6-phosphate
      N-acetyltransferase (GNA1) originating from Saccharomyces
      cerevisiae

<400> 83
atgagcttac ccgatggatt ttatataagg cgaatggaag agggggattt ggaacaggtc      60

actgagacgc taaaggtttt gaccaccgtg ggcactatta cccccgaatc cttcagcaaa     120

ctcataaaat actggaatga agccacagta tggaatgata acgaagataa aaaaataatg     180

caatataacc ccatggtgat tgtggacaag cgcaccgaga cggttgccgc tacggggaat     240

atcatcatcg aaagaaagat cattcatgaa ctggggctat gtggccacat cgaggacatt     300

gcagtaaact ccaagtatca gggccaaggt ttgggcaagc tcttgattga tcaattggta     360

actatcggct ttgactacgg ttgttataag attattttag attgcgatga gaaaaatgtc     420

aaattctatg aaaaatgtgg gtttagcaac gcaggcgtgg aaatgcaaat tagaaaatag     480


<210> 84
<211> 159
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> amino acid sequence of Glucosamine 6-phosphate
      N-acetyltransferase (GNA1) originating from Saccharomyces
      cerevisiae

<400> 84
Met Ser Leu Pro Asp Gly Phe Tyr Ile Arg Arg Met Glu Glu Gly Asp 
1               5                   10                  15      
Leu Glu Gln Val Thr Glu Thr Leu Lys Val Leu Thr Thr Val Gly Thr 
            20                  25                  30          
Ile Thr Pro Glu Ser Phe Ser Lys Leu Ile Lys Tyr Trp Asn Glu Ala 
        35                  40                  45              
Thr Val Trp Asn Asp Asn Glu Asp Lys Lys Ile Met Gln Tyr Asn Pro 
    50                  55                  60                  
Met Val Ile Val Asp Lys Arg Thr Glu Thr Val Ala Ala Thr Gly Asn 
65                  70                  75                  80  
Ile Ile Ile Glu Arg Lys Ile Ile His Glu Leu Gly Leu Cys Gly His 
                85                  90                  95      
Ile Glu Asp Ile Ala Val Asn Ser Lys Tyr Gln Gly Gln Gly Leu Gly 
            100                 105                 110         
Lys Leu Leu Ile Asp Gln Leu Val Thr Ile Gly Phe Asp Tyr Gly Cys 
        115                 120                 125             
Tyr Lys Ile Ile Leu Asp Cys Asp Glu Lys Asn Val Lys Phe Tyr Glu 
    130                 135                 140                 
Lys Cys Gly Phe Ser Asn Ala Gly Val Glu Met Gln Ile Arg Lys 
145                 150                 155                 

<210> 85
<211> 1674
<212> DNA
<213> Saccharomyces cerevisiae


<220> 
<223> nucleic acid sequence of phosphoacetylglucosamine mutase (PCM1)
      originating from Saccharomyces cerevisiae

<400> 85
atgaaggttg attacgagca attgtgcaaa ctctacgatg acacgtgccg cacaaagaat      60

gtgcagttca gttacggtac ggccggattc agaacgctgg ccaagaattt ggatacggtg     120

atgttcagta ctggtatact ggcggttctc aggtcgctga agcttcaggg tcagtatgtg     180

ggggtgatga tcacggcgtc gcacaaccca taccaggaca acggggtcaa gatcgtggaa     240

ccagacggat cgatgctttt ggccacatgg gagccatatg ccatgcagtt ggccaatgcg     300

gcctcttttg ccactaattt tgaagaattt cgtgttgagt tggccaagct gattgaacac     360

gaaaagattg atttgaatac aaccgtcgtg cctcacatcg tggttgggag agactctagg     420

gaaagtagtc catacttgct gcgctgcttg acttcctcca tggccagcgt cttccacgcg     480

caagttttgg acctaggctg tgtcactacg cctcaattgc attacattac tgatttgtcc     540

aacaggcgga aactggaagg agacacagcg ccagttgcca cagaacagga ctactattcg     600

ttctttatag gagccttcaa cgagctcttc gccacgtatc agctggagaa gaggctgtct     660

gtcccaaaat tgttcataga cacagccaat ggtatcggtg gtccacagtt gaaaaaacta     720

ctggcctccg aagattggga cgtgccagcg gagcaagttg aggtaatcaa cgacaggtcc     780

gatgttccag aactgttgaa ttttgaatgc ggtgcggatt atgtgaagac taaccagaga     840

ttacccaagg gtctttctcc atcctcgttt gattcgctat attgctcctt tgatggtgac     900

gcagacaggg ttgtgttcta ctatgtcgac tcaggatcaa aatttcattt gttggatggt     960

gacaaaattt ccactttgtt tgcaaagttc ttgtctaaac aactagaatt ggcacaccta    1020

gaacattctt tgaagattgg tgttgtgcaa actgcctatg caaacggcag ttccaccgct    1080

tacataaaaa atacgttgca ctgtcccgtg tcttgcacta agacaggtgt taaacacttg    1140

catcatgaag ctgccactca gtacgatatt ggcatttatt tcgaagcaaa tggacatggt    1200

acgattatat tcagcgaaaa atttcatcga actatcaaat ctgaattatc caagtccaag    1260

ttaaatggtg atacgttagc tttgagaact ttgaagtgtt tctctgaatt gattaatcag    1320

accgtgggag atgctatttc agacatgctt gctgtccttg ctactttggc gattttgaaa    1380

atgtcgccaa tggattggga tgaagagtat actgatttgc ccaacaagct ggttaagtgc    1440

atcgttcctg ataggtcaat tttccaaacc acggaccagg aaagaaaatt gctcaatcca    1500

gtggggttgc aagacaagat agatcttgtg gtagccaagt atcccatggg aagaagcttt    1560

gtcagagcca gtggtacgga ggatgcggtg agggtttatg cggaatgtaa ggactcctct    1620

aagttaggtc aattttgtga cgaagtggtg gagcacgtta aggcatctgc ttga          1674


<210> 86
<211> 557
<212> PRT
<213> Saccharomyces cerevisiae


<220> 
<223> amino acid sequence of phosphoacetylglucosamine mutase (PCM1)
      originating from Saccharomyces cerevisiae

<400> 86
Met Lys Val Asp Tyr Glu Gln Leu Cys Lys Leu Tyr Asp Asp Thr Cys 
1               5                   10                  15      
Arg Thr Lys Asn Val Gln Phe Ser Tyr Gly Thr Ala Gly Phe Arg Thr 
            20                  25                  30          
Leu Ala Lys Asn Leu Asp Thr Val Met Phe Ser Thr Gly Ile Leu Ala 
        35                  40                  45              
Val Leu Arg Ser Leu Lys Leu Gln Gly Gln Tyr Val Gly Val Met Ile 
    50                  55                  60                  
Thr Ala Ser His Asn Pro Tyr Gln Asp Asn Gly Val Lys Ile Val Glu 
65                  70                  75                  80  
Pro Asp Gly Ser Met Leu Leu Ala Thr Trp Glu Pro Tyr Ala Met Gln 
                85                  90                  95      
Leu Ala Asn Ala Ala Ser Phe Ala Thr Asn Phe Glu Glu Phe Arg Val 
            100                 105                 110         
Glu Leu Ala Lys Leu Ile Glu His Glu Lys Ile Asp Leu Asn Thr Thr 
        115                 120                 125             
Val Val Pro His Ile Val Val Gly Arg Asp Ser Arg Glu Ser Ser Pro 
    130                 135                 140                 
Tyr Leu Leu Arg Cys Leu Thr Ser Ser Met Ala Ser Val Phe His Ala 
145                 150                 155                 160 
Gln Val Leu Asp Leu Gly Cys Val Thr Thr Pro Gln Leu His Tyr Ile 
                165                 170                 175     
Thr Asp Leu Ser Asn Arg Arg Lys Leu Glu Gly Asp Thr Ala Pro Val 
            180                 185                 190         
Ala Thr Glu Gln Asp Tyr Tyr Ser Phe Phe Ile Gly Ala Phe Asn Glu 
        195                 200                 205             
Leu Phe Ala Thr Tyr Gln Leu Glu Lys Arg Leu Ser Val Pro Lys Leu 
    210                 215                 220                 
Phe Ile Asp Thr Ala Asn Gly Ile Gly Gly Pro Gln Leu Lys Lys Leu 
225                 230                 235                 240 
Leu Ala Ser Glu Asp Trp Asp Val Pro Ala Glu Gln Val Glu Val Ile 
                245                 250                 255     
Asn Asp Arg Ser Asp Val Pro Glu Leu Leu Asn Phe Glu Cys Gly Ala 
            260                 265                 270         
Asp Tyr Val Lys Thr Asn Gln Arg Leu Pro Lys Gly Leu Ser Pro Ser 
        275                 280                 285             
Ser Phe Asp Ser Leu Tyr Cys Ser Phe Asp Gly Asp Ala Asp Arg Val 
    290                 295                 300                 
Val Phe Tyr Tyr Val Asp Ser Gly Ser Lys Phe His Leu Leu Asp Gly 
305                 310                 315                 320 
Asp Lys Ile Ser Thr Leu Phe Ala Lys Phe Leu Ser Lys Gln Leu Glu 
                325                 330                 335     
Leu Ala His Leu Glu His Ser Leu Lys Ile Gly Val Val Gln Thr Ala 
            340                 345                 350         
Tyr Ala Asn Gly Ser Ser Thr Ala Tyr Ile Lys Asn Thr Leu His Cys 
        355                 360                 365             
Pro Val Ser Cys Thr Lys Thr Gly Val Lys His Leu His His Glu Ala 
    370                 375                 380                 
Ala Thr Gln Tyr Asp Ile Gly Ile Tyr Phe Glu Ala Asn Gly His Gly 
385                 390                 395                 400 
Thr Ile Ile Phe Ser Glu Lys Phe His Arg Thr Ile Lys Ser Glu Leu 
                405                 410                 415     
Ser Lys Ser Lys Leu Asn Gly Asp Thr Leu Ala Leu Arg Thr Leu Lys 
            420                 425                 430         
Cys Phe Ser Glu Leu Ile Asn Gln Thr Val Gly Asp Ala Ile Ser Asp 
        435                 440                 445             
Met Leu Ala Val Leu Ala Thr Leu Ala Ile Leu Lys Met Ser Pro Met 
    450                 455                 460                 
Asp Trp Asp Glu Glu Tyr Thr Asp Leu Pro Asn Lys Leu Val Lys Cys 
465                 470                 475                 480 
Ile Val Pro Asp Arg Ser Ile Phe Gln Thr Thr Asp Gln Glu Arg Lys 
                485                 490                 495     
Leu Leu Asn Pro Val Gly Leu Gln Asp Lys Ile Asp Leu Val Val Ala 
            500                 505                 510         
Lys Tyr Pro Met Gly Arg Ser Phe Val Arg Ala Ser Gly Thr Glu Asp 
        515                 520                 525             
Ala Val Arg Val Tyr Ala Glu Cys Lys Asp Ser Ser Lys Leu Gly Gln 
    530                 535                 540                 
Phe Cys Asp Glu Val Val Glu His Val Lys Ala Ser Ala 
545                 550                 555         

<210> 87
<211> 574
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTDH3

<400> 87
ctgctgtaac ccgtacatgc ccaaaatagg gggcgggtta cacagaatat ataacatcgt      60

aggtgtctgg gtgaacagtt tattcctggc atccactaaa tataatggag cccgcttttt     120

aagctggcat ccagaaaaaa aaagaatccc agcaccaaaa tattgttttc ttcaccaacc     180

atcagttcat aggtccattc tcttagcgca actacagaga acaggggcac aaacaggcaa     240

aaaacgggca caacctcaat ggagtgatgc aacctgcctg gagtaaatga tgacacaagg     300

caattgaccc acgcatgtat ctatctcatt ttcttacacc ttctattacc ttctgctctc     360

tctgatttgg aaaaagctga aaaaaaaggt tgaaaccagt tccctgaaat tattccccta     420

cttgactaat aagtatataa agacggtagg tattgattgt aattctgtaa atctatttct     480

taaacttctt aaattctact tttatagtta gtcttttttt tagttttaaa acaccaagaa     540

cttagtttcg aataaacaca cataaacaaa caaa                                 574


<210> 88
<211> 585
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTDH3.Sk

<400> 88
caattcatcg gcccttttag cggctacccg cgccatctaa atgatagggc gggtgacact      60

atggtaaatc ccataattag gtgtctgggt gagtggttct gatgccggca tccactaaat     120

atattggagc ccatttttta cgcgggcttc cagaaaaaaa gagaatccca gcaccaaaag     180

gtggttctct tcaccaacca tcagatcata ggtccacaac cacacataac aggggcacaa     240

aaaggcaaaa aacggacata acctcaatgg agtgatgcaa attgactgga gcaaaagctg     300

acacaaggca ttgattgacc tacgcatgta tctgtattct tttcttacac cttctattac     360

cttctaactc tttgggttgg aaaaaactga aaaaaaaggt tgggacctgg ttcccccaag     420

ttgtccccct acttggttat taaatatata aagacagcaa gtgttgatta taatcttgta     480

aatctatagt tcttaatcta tacttctatt tatattttaa attagtcttt ttatttccaa     540

gtccccaaga acttagtttc gaataaacac acacaaataa acaca                     585


<210> 89
<211> 700
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTDH3-1.sba

<400> 89
gcagcgcttc ttccgctcta gtttttatag ttattattac taccacctta aaaatacgta      60

aatactcaaa atagtagtga tattcccaac cttattcatc caaggcacat catcatcatc     120

agccattcat ctttcacctg ccattagtaa cccgtcttct cattgagcgg gttacggcag     180

ccacaggcca cattccgaat gtctgggtga gcggtccctt ttccagcatc cactaaatat     240

ctccgatccc gctttttaat ctggcttcct gaaaaaaaga gaatcccagc accaaaaaat     300

ggctctcttc accaaccatc agatcatagg tcccattctc ttaccgcaac cgtacagaac     360

aggggaaaac gggtacaacc tcaatggagt gatgcaaact gactggagca aaaagctgac     420

acaaggcaat cgacctacgt gtctgtctat tttctcacac cttctattac cttctaactc     480

tctgggttgg aaaaaactga aaaaaaggtt gagaccagtt tccacaaatc atccccctgt     540

ttgattaata aatatataaa gacgacaact atcgatcata aactcataaa actataactc     600

ctttacactt cttattttat agttattcta ttttaattct tattgatttt aaaaccccaa     660

gaacttagtt tcgaaaacac acacacacaa acaattaaaa                           700


<210> 90
<211> 602
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTDH3.Sar

<400> 90
gagctaaata tcagcccttc gggtcctgcc tgctacccgg tcctgttcga ataaaaacgc      60

gggtaacacg acccagtaac acctgtcgtt gggtgtctgg gtcagaagtt ctgataccgg     120

cttccactaa atagattggg ttccgctctt tacgctggct tcctgaaaaa agagattccg     180

ggcaccaaaa aattggtctc tttgccaacc atcagatcat aggtccattc tcttaccata     240

accacacagg ataggggcac cacaggcgaa aatgggcaca aaatctcaat ggagtgatgc     300

aaattagctg gaacaaaagc tgacacaagg caattaacct gcgcatgtat ccatctcctt     360

ttcttacacc ttctcttacg ttctaactgt ttgggttgga aaaattaaaa aaaaaaggtt     420

gagaccagtt tccccaaatc gtccccctac ttgattcata aatatataaa gacgacaact     480

attgattata atcttgtaaa tctataactc tttactttct cctatttata atttaactta     540

atctttttag atttaaaacc ccaagaactt agtttcgaac aaacacacac aaataaacaa     600

aa                                                                    602


<210> 91
<211> 550
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pENO2

<400> 91
cgctcagcat ctgcttcttc ccaaagatga acgcggcgtt atgtcactaa cgacgtgcac      60

caacttgcgg aaagtggaat cccgttccaa aactggcatc cactaattga tacatctaca     120

caccgcacgc cttttttctg aagcccactt tcgtggactt tgccatatgc aaaattcatg     180

aagtgtgata ccaagtcagc atacacctca ctagggtagt ttctttggtt gtattgatca     240

tttggttcat cgtggttcat taattttttt tctccattgc tttctggctt tgatcttact     300

atcatttgga tttttgtcga aggttgtaga attgtatgtg acaagtggca ccaagcatat     360

ataaaaaaaa aaagcattat cttcctacca gagttgattg ttaaaaacgt atttatagca     420

aacgcaattg taattaattc ttattttgta tcttttcttc ccttgtctca atcttttatt     480

tttattttat ttttcttttc ttagtttctt tcataacacc aagcaactaa tactataaca     540

tacaataata                                                            550


<210> 92
<211> 598
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTEF3

<400> 92
ggctgataat agcgtataaa caatgcatac tttgtacgtt caaaatacaa tgcagtagat      60

atatttatgc atattacata taatacatat cacataggaa gcaacaggcg cgttggactt     120

ttaattttcg aggaccgcga atccttacat cacacccaat cccccacaag tgatccccca     180

cacaccatag cttcaaaatg tttctactcc ttttttactc ttccagattt tctcggactc     240

cgcgcatcgc cgtaccactt caaaacaccc aagcacagca tactaaattt cccctctttc     300

ttcctctagg gtgtcgttaa ttacccgtac taaaggtttg gaaaagaaaa aagagaccgc     360

ctcgtttctt tttcttcgtc gaaaaaggca ataaaaattt ttatcacgtt tctttttctt     420

gaaaattttt ttttttgatt tttttctctt tcgatgacct cccattgata tttaagttaa     480

taaacggtct tcaatttctc aagtttcagt ttcatttttc ttgttctatt acaacttttt     540

ttacttcttg ctcattagaa agaaagcata gcaatctaat ctaagtttta attacaaa       598


<210> 93
<211> 383
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTEF1

<400> 93
gtttagcttg cctcgtcccc gccgggtcac ccggccagcg acatggaggc ccagaatacc      60

ctccttgaca gtcttgacgt gcgcagctca ggggcatgat gtgactgtcg cccgtacatt     120

tagcccatac atccccatgt ataatcattt gcatccatac attttgatgg ccgcacggcg     180

cgaagcaaaa attacggctc ctcgctgcag acctgcgagc agggaaacgc tcccctcaca     240

gacgcgttga attgtcccca cgccgcgccc ctgtagagaa atataaaagg ttaggatttg     300

ccactgaggt tcttctttca tatacttcct tttaaaatct tgctacgata cagttctcac     360

atcacatccg aacataaaca acc                                             383


<210> 94
<211> 383
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTEF1.ago

<400> 94
gtttagcttg cctcgtcccc gccgggtcac ccggccagcg acatggaggc ccagaatacc      60

ctccttgaca gtcttgacgt gcgcagctca ggggcatgat gtgactgtcg cccgtacatt     120

tagcccatac atccccatgt ataatcattt gcatccatac attttgatgg ccgcacggcg     180

cgaagcaaaa attacggctc ctcgctgcag acctgcgagc agggaaacgc tcccctcaca     240

gacgcgttga attgtcccca cgccgcgccc ctgtagagaa atataaaagg ttaggatttg     300

ccactgaggt tcttctttca tatacttcct tttaaaatct tgctacgata cagttctcac     360

atcacatccg aacataaaca acc                                             383


<210> 95
<211> 498
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pTEF1.Sba

<400> 95
cgccaacaaa ccttcgaaca ctttaatttt cgaggaccgc agatcctcac atcacaccca      60

cacccaagac tgcttccccc acacaccctg catctgtaca ctttcttctg ctctgttttt     120

ctctccggcg ttctctcggg tcgcccgcat cgccgcgccg gctggaaccg cccacgcacc     180

gcatattgca aatcgcctgc cccctcttgc tcctttttga gggcgcgccg ttacccgcgc     240

ccagggtccg gaaaaagaaa caaggctcta ccgcgtttct ttttccttgt cgaaaaaggc     300

aaaaatgaaa atttttatca cgtttctttt tttttgaaaa attttttttt tggttttttt     360

tctttcgatg gcctcccatt gatatttaag ttaataaatg gttttcagtt ttcaagtttc     420

agtttgtgtt cttctttgct aactttcact tacacctcga aagaaagtat agcaatctaa     480

tcttagtttt aattacaa                                                   498


<210> 96
<211> 700
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pPDC1

<400> 96
ttatttacct atctctaaac ttcaacacct tatatcataa ctaatatttc ttgagataag      60

cacactgcac ccataccttc cttaaaaacg tagcttccag tttttggtgg ttccggcttc     120

cttcccgatt ccgcccgcta aacgcatatt tttgttgcct ggtggcattt gcaaaatgca     180

taacctatgc atttaaaaga ttatgtatgc tcttctgact tttcgtgtga tgaggctcgt     240

ggaaaaaatg aataatttat gaatttgaga acaattttgt gttgttacgg tattttacta     300

tggaataatc aatcaattga ggattttatg caaatatcgt ttgaatattt ttccgaccct     360

ttgagtactt ttcttcataa ttgcataata ttgtccgctg cccctttttc tgttagacgg     420

tgtcttgatc tacttgctat cgttcaacac caccttattt tctaactatt ttttttttag     480

ctcatttgaa tcagcttatg gtgatggcac atttttgcat aaacctagct gtcctcgttg     540

aacataggaa aaaaaaatat ataaacaagg ctctttcact ctccttgcaa tcagatttgg     600

gtttgttccc tttattttca tatttcttgt catattcctt tctcaattat tattttctac     660

tcataacctc acgcaaaata acacagtcaa atcaatcaaa                           700


<210> 97
<211> 924
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW12

<400> 97
aactgtaaac aggtacaatg cggacccttt tgccacaaaa catacatcat tcattgccgg      60

aaaaagaaag aagtgaagac agcagtgcag ccagccatgt tgcgccaatc taattataga     120

tgctggtgcc ctgaggatgt atctggagcc agccatggca tcatgcgcta ccgccggatg     180

taaaatccga cacgcaaaag aaaaccttcg aggttgcgca cttcgcccac ccatgaacca     240

cacggttagt ccaaaagggg cagttcagat tccagatgcg ggaattagct tgctgccacc     300

ctcacctcac taacgctgcg gtgtgcggat acttcatgct atttatagac gcgcgtgtcg     360

gaatcagcac gcgcaagaac caaatgggaa aatcggaatg ggtccagaac tgctttgagt     420

gctggctatt ggcgtctgat ttccgttttg ggaatccttt gccgcgcgcc cctctcaaaa     480

ctccgcacaa gtcccagaaa gcgggaaaga aataaaacgc caccaaaaaa aaaaataaaa     540

gccaatcctc gaagcgtggg tggtaggccc tggattatcc cgtacaagta tttctcagga     600

gtaaaaaaac cgtttgtttt ggaattcccc atttcgcggc cacctacgcc gctatctttg     660

caacaactat ctgcgataac tcagcaaatt ttgcatattc gtgttgcagt attgcgataa     720

tgggagtctt acttccaaca taacggcaga aagaaatgtg agaaaatttt gcatcctttg     780

cctccgttca agtatataaa gtcggcatgc ttgataatct ttctttccat cctacattgt     840

tctaattatt cttattctcc tttattcttt cctaacatac caagaaatta atcttctgtc     900

attcgcttaa acactatatc aata                                            924


<210> 98
<211> 976
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW12.Sm

<400> 98
cgttgtgctg tagtgaagga agactaaaaa ggataatcac agttgtaaag aggtataatg      60

cggacccttt tgccacaaaa cacacatctt tcgtttccaa aataagaaag aagaaagcaa     120

aaagattagc agccacgttg ctgcgatcta attatagacg gtggcgtcat cattctcacc     180

caagattgtg tcttgaacct gccacgggtc ctgcgttatc gccggatgta aaactagaca     240

tgcaaaaaaa ggaccttcca ggtagcgtgc tccacaccac ccatgaccac cacagttagt     300

ccaaaagagg cagcaccact tcccgatggg ggaattagat tgctgccacc ctcacctcac     360

taatgctgcg gtgtgcggat atgccctgct atatatagct ccgcgttttt gaaccagcac     420

agcgcgagca ccaaaaagga aaatcgcata ggcccagaac tgatttcagc acgggctatt     480

ggcgttgggt ttccgttctg ggaaaccttc gccgcgtccc cctcacaaac ctccgcacaa     540

gttcgagcaa gcgggaaaaa acgaaaaacg ccattaatac taaataaagc aaatcctcga     600

agcgtgggtg gcaagcccct ggatttttcc gcacaagtac tcttctcagg agtaaaaaaa     660

cccgtttgtt ttggaattcc ccatttcgcg gccatctacg ccggtatctt cgcaatatct     720

atcagcgata actcagcaat tttaatattc gtgttgcagt gctgcgatag cgggagtctt     780

gtttgtaaca taacggcaga aaggaatgag agaaaatttt ccattctttg gcctccgttc     840

aagtatataa agccggcatg cttggtaatc tttctctctc ttctgtattg tttctataat     900

acttttatct tctaattatt ttctgaaaaa accaagaaat taatcttctg tcattcgctt     960

aaacactata tcaata                                                     976


<210> 99
<211> 750
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW12.Sk

<400> 99
tgtaaaatcc tacacgcaaa aaacctcttg ggttgcgcgt tttccaccac ccacgacccg      60

cacaatcaat ccaaaagggg caacgccagt tcccaatgcg ggaattagct cctcaccccc     120

ctcacccgct aacgctgcgg tgtgcggaca cgcagcagta tttatagatc ctcgtgttgg     180

aaccagcccg cgtgagcacc aaattggaaa gtcgcaatgg gcccagaacc gctttcagta     240

ctgggccatt ggcgtctagt ttccgttttg agcgtccttc gccgcgtctc tctgtgaaat     300

ccccgcacaa gtctgagcag gcaaaaaaaa aaaacgccac caaaaataaa taaagccaat     360

cctcgaagga tgagtaggaa aggaagcccc tggttttttc ccgcacgaat atttttcagg     420

agtgaaaaaa tccgtttgtt ttggaattcc ccatttcgcg ctcacctacg ccggtatctt     480

tggaacaact atcagcgata actcagcaaa atttgcatat ccgtgctgca atagtgcgat     540

agtgggattg ggagtcttgt tgcatcataa cggcagaaag gaatgaataa aaattttccg     600

ttctttgtct ccgttcaagt atataaagtc ggcatgcttg attatctttt cttctcttct     660

actacatttc tatttcactt tctactctat tcttccctga aaaacccaag aaaataatct     720

tctgtcattc gcttaaacaa tatatcaaaa                                      750


<210> 100
<211> 750
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW12.Sba

<400> 100
accatgccac ggtgctggcc ccacttccac ccacgacccg cacggttggc ccgaaagggg      60

caacaccagt tcccaatacg gaaattagtc cgccaccacc ctcacctcgc tagagctgcg     120

gtgtgcgggc gtgcatcgct atttatagac atgcctgctg gcgtcaccgc gcgcgagcac     180

caaacaggaa aatcgcactg ggcccagaac cacgctatgc gctgggccga tggcgtccgg     240

tttccctttg ggagccccct gccacgttcg cctaacaaat ccccgcaccg gcttgagaaa     300

aaagcgaaaa gcgaaaaaaa aaaatcaacg ccaccaaaat taaaaaaaaa gagccatcct     360

cgaagggtga atagtagccc ctgacttttc ccgcacagac agacaccttt caggagtgaa     420

caaaaaagca gtttgttttg gaattccccc atttcgcggt ggcctgcgca ggtatctctg     480

cgtcaactat cagcgataac tcagcaaatt ttgcatattc gtgttgcgat actacgataa     540

tgggagtctg tcgcctaata acggcaacaa ggaatgagag agaaaaattt tcttcattct     600

ccagctcccg ttcaagtata taaggtcggc atggtcgatt gtctttcctt ctcttcagtt     660

acgtctctct atttacatta ttcttatttt tatttaataa aaaccccaag aaattaatct     720

tctgtcattc gcttaaacac tatatcaaaa                                      750


<210> 101
<211> 750
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW12.Sar

<400> 101
aaaaaacaac cttctgccaa cctgcgtgct tctcaccacc catgacccac acaattgacc      60

cgaatggggc aactccagtt cccaatacgg gaattaactc gccaccatat ttaccgcgtt     120

gaagctgtgg tgtgcggaca ctccgtacta tttatagacc cacgcggtgg aaccagcacg     180

cgcgcgcact aaacaggaaa atcgcattga gtccagaacc gccaccagca cttggccatt     240

ggcgtctaat ttccgttttc ggcgcccctc accgcgtcct tctaacaaag cgcgcacaag     300

cttgagcaag tgaaaagaaa attaaaaata aaaaaccgcc accaaaacaa ataaagcaat     360

cttcgaagtg tgggttggtg ggaagcccct ggcttttccc gcaccagtcg ttttcaggag     420

taaaaaaata cccgtttgtt ttggaattcc ccatttcgcg gcgacctgcg ccggtatctt     480

tgcaacaact atttgcgata actcagcaaa atttgcatat tcgtgttggg atattgcgat     540

agtgggagtc ttgttgcata ataacggtaa aaagaagtga aggaaaaaaa tttgcatcct     600

ttagtctcag ttcaagtata taaagtcggg atattcaatt atctttcttt ctcttgctca     660

aaggtttcta tatttttttt atagtatttc ttttgttata aaataccaag aaattaatct     720

tctgtcattc gcttaaatac tacatcaata                                      750


<210> 102
<211> 500
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pNUP57

<400> 102
tcatctgcgc aatgactatc aagaccttct gcaagaattt caaatctcac tgaaaatctt      60

gaccgaaaag tgtcttgaaa acccatcaag cctgcaaaac ctatctttga cattagtctc     120

cattataaaa acggcatagt tgggagaaaa ctttccatac ttcaattgtg gactgatata     180

agtattttag ttttgcccgc atgatcatcc cacatggcta cagcagttct ctcataggaa     240

aatagtacaa tagctacgtg atataatcta aataattgtt gccaatgtgt aattatatca     300

ttttgaacgt acgcgaaatg gattattttc aaaaattttg tttcttgaaa tgagtaaaag     360

caaaagtcca actctccaag tcgatgtaaa caactttttg ccaaagggac tgaaagacta     420

aatcgaggat tatcccgttc aaactattcc agaaacgctc gttagtaaca aaagacatac     480

cttgttgacc aattgatcac                                                 500


<210> 103
<211> 523
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW10.ago

<400> 103
ggtaccacgg caacctcgtt cgctgttcat ccccttcgtc acacaggacg ttggatgccg      60

taagcagcgt tgcttttgat cctcaggatc ggccgggtaa cccgcggctg cttctatttt     120

agtattcata tctcaagcac atccattccg gccgtttggg ggcgccgccg cactcgtgtc     180

cattcctacc gtggcactta gggctatcct gtcggagcgc cccgccgacc gccttatcgg     240

caccaaaagt agaagccccg gccccgcgtg gctcagactc accatcggtg ctatttactt     300

ttcgatcaga tcgcggcgcg cggtggccgg catttccgga agcggccacg gagcagaggt     360

ggcgcattcg aatcgcatac gtcttcgcca cgccggaaaa aaaattttcg gctatataag     420

gagaggcggc cgtcttgctg caggcagttt cactttctct aaaaccaaag aacatcgatt     480

tctttagtca ctcgcttcct tacaccgaac tcgaggcggc cgc                       523


<210> 104
<211> 943
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCWP2

<400> 104
ctagcctccc ctttttattt tgtgcggtca ccgcaaggga caaagctttt cttagaaaac      60

cgtctgagaa gcataacgta cgccatcccc tagacatatt aataatgcta cagatactat     120

gctgctcgtc tttttttgac gaccctttta ttgcaatgtg caactaatgg caaacaacca     180

catagtatca cagtattaca ttgcctccac cgatgcggat gttagggcgc caagtctgtc     240

atgaagcatg ttcctgtcat aatcttgtat gcaaaatacc gcgttctgcg ccactgatat     300

gctaggcagc agcaacctat gcagaagatt gcttttccca cgcctgtttt acgtctccag     360

ggcacttgaa acaatgcagc gatcgccgcc acaacacgcc aaagagaagc gaaagtgggc     420

ctgggcggcc tcagtttcgg cagaggtaaa caacacgaac tgaactgcct tagctccgaa     480

gggcaattcc acaggcactc cgcggggccc ggccaaggcc caaaaggcgt ggaatatgcg     540

cgttttgggg ccataacacc cagtaccacg gccggaacgg gccatataat aagtttttca     600

ctctcaagaa tggtaaacgt aaataggaac atcccactac cctagaaatt gcggaaattt     660

cgcgcttatc attagaaaat ctggaaccgt cctttttcct ctttcttgca tttccctttc     720

cgtattattg ccattcttta actgcatttg gggaaccgta gaccaaaagc caaacagaga     780

aatgtaacgt tctaaaaaaa aaacaacgaa aaaattgaaa aataagatac aataatcgta     840

tataaatcag gcttcttgtt catcattttc aattctcttc ttgccatccc ttttcctatc     900

tttgttcttt tcttctcata atcaagaata aataacttca tca                       943


<210> 105
<211> 650
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pFBA1

<400> 105
acgcaagccc taagaaatga ataacaatac tgacagtact aaataattgc ctacttggct      60

tcacatacgt tgcatacgtc gatatagata ataatgataa tgacagcagg attatcgtaa     120

tacgtaatag ttgaaaatct caaaaatgtg tgggtcatta cgtaaataat gataggaatg     180

ggattcttct atttttcctt tttccattct agcagccgtc gggaaaacgt ggcatcctct     240

ctttcgggct caattggagt cacgctgccg tgagcatcct ctctttccat atctaacaac     300

tgagcacgta accaatggaa aagcatgagc ttagcgttgc tccaaaaaag tattggatgg     360

ttaataccat ttgtctgttc tcttctgact ttgactcctc aaaaaaaaaa aatctacaat     420

caacagatcg cttcaattac gccctcacaa aaactttttt ccttcttctt cgcccacgtt     480

aaattttatc cctcatgttg tctaacggat ttctgcactt gatttattat aaaaagacaa     540

agacataata cttctctatc aatttcagtt attgttcttc cttgcgttat tcttctgttc     600

ttctttttct tttgtcatat ataaccataa ccaagtaata catattcaaa                650


<210> 106
<211> 996
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCCW120.Sm

<400> 106
cgttgtgctg tagtgaagga agactaaaaa ggataatcac agttgtaaag aggtataatg      60

cggacccttt tgccacaaaa cacacatctt tcgtttccaa aataagaaag aagaaagcaa     120

aaagattagc agccacgttg ctgcgatcta attatagacg gtggcgtcat cattctcacc     180

caagattgtg tcttgaacct gccacgggtc ctgcgttatc gccggatgta aaactagaca     240

tgcaaaaaaa ggaccttcca ggtagcgtgc tccacaccac ccatgaccac cacagttagt     300

ccaaaagagg cagcaccact tcccgatggg ggaattagat tgctgccacc ctcacctcac     360

taatgctgcg gtgtgcggat atgccctgct atatatagct ccgcgttttt gaaccagcac     420

agcgcgagca ccaaaaagga aaatcgcata ggcccagaac tgatttcagc acgggctatt     480

ggcgttgggt ttccgttctg ggaaaccttc gccgcgtccc cctcacaaac ctccgcacaa     540

gttcgagcaa gcgggaaaaa acgaaaaacg ccattaatac taaataaagc aaatcctcga     600

agcgtgggtg gcaagcccct ggatttttcc gcacaagtac tcttctcagg agtaaaaaaa     660

cccgtttgtt ttggaattcc ccatttcgcg gccatctacg ccggtatctt cgcaatatct     720

atcagcgata actcagcaat tttaatattc gtgttgcagt gctgcgatag cgggagtctt     780

gtttgtaaca taacggcaga aaggaatgag agaaaatttt ccattctttg gcctccgttc     840

aagtatataa agccggcatg cttggtaatc tttctctctc ttctgtattg tttctataat     900

acttttatct tctaattatt ttctgaaaaa accaagaaat taatcttctg tcattcgctt     960

aaacactata tcaatactcg aaatccaagg tggtgt                               996


<210> 107
<211> 505
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pCUP1

<400> 107
cggcaaactt caacgatttc tatgatgcat tttataatta gtaagccgat cccattaccg      60

acatttgggc gctatacgtg catatgttca tgtatgtatc tgtatttaaa acacttttgt     120

attatttttc ctcatatatg tgtataggtt tatacggatg atttaattat tacttcacca     180

ccctttattt caggctgata tcttagcctt gttactagtt agaaaaagac atttttgctg     240

tcagtcactg tcaagagatt cttttgctgg catttcttct agaagcaaaa agagcgatgc     300

gtcttttccg ctgaaccgtt ccagcaaaaa agactaccaa cgcaatatgg attgtcagaa     360

tcatataaaa gagaagcaaa taactccttg tcttgtatca attgcattat aatatcttct     420

tgttagtgca atatcatata gaagtcatcg aaatagatat taagaaaaac aaactgtaca     480

atcaatcaat caatcatcac ataaa                                           505


<210> 108
<211> 510
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pMET6

<400> 108
ccacaggaaa tatttcacgt gacttacaaa cagagtcgta cgtcaggacc ggagtcaggt      60

gaaaaaatgt gggccggtaa agggaaaaaa ccagaaacgg gactactatc gaactcgttt     120

agtcgcgaac gtgcaaaagg ccaatatttt tcgctagagt catcgcagtc atggcagctc     180

tttcgctcta tctcccggtc gcaaaactgt ggtagtcata gctcgttctg ctcaattgag     240

aactgtgaat gtgaatatgg aacaaatgcg atagatgcac taatttaagg gaagctagct     300

agttttccca actgcgaaag aaaaaaagga aagaaaaaaa aattctatat aagtgataga     360

tatttccatc tttactagca ttagtttctc ttttacgtat tcaatatttt tgttaaactc     420

ttcctttatc ataaaaaagc aagcatctaa gagcattgac aacactctaa gaaacaaaat     480

accaatataa tttcaaagta catatcaaaa                                      510


<210> 109
<211> 686
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pMET25

<400> 109
ttacattatc aatccttgcg tttcagcttc cactaattta gatgactatt tctcatcatt      60

tgcgtcatct tctaacaccg tatatgataa tatactagta acgtaaatac tagttagtag     120

atgatagttg atttttattc caacactaag aaataatttc gccatttctt gaatgtattt     180

aaagatattt aatgctataa tagacattta aatccaattc ttccaacata caatgggagt     240

ttggccgagt ggtttaaggc gtcagattta ggtggattta acctctaaaa tctctgatat     300

cttcggatgc aagggttcga atcccttagc tctcattatt ttttgctttt tctcttgagg     360

tcacatgatc gcaaaatggc aaatggcacg tgaagctgtc gatattgggg aactgtggtg     420

gttggcaaat gactaattaa gttagtcaag gcgccatcct catgaaaact gtgtaacata     480

ataaccgaag tgtcgaaaag gtggcacctt gtccaattga acacgctcga tgaaaaaaat     540

aagatatata taaggttaag taaagcgtct gttagaaagg aagtttttcc tttttcttgc     600

tctcttgtct tttcatctac tatttccttc gtgtaataca gggtcgtcag atacatagat     660

acaattctat tacccccatc cataca                                          686


<210> 110
<211> 363
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of promoter pSAM1

<400> 110
gaaacggacg taagacggaa atagaatttg aagataaagt tatatatcac tacacacgaa      60

tactttcttt tttttttttc acaggaaaac tgtggtggcg cccttgccta ctagtgcatt     120

tcttttttcg ggttcttgtc tcgacgaaat tttagcctca tcgtagtttt tcactctggt     180

atcgatgaaa aagggaagag taaaaagttt tccgtttagt acttaatggg attggtttgg     240

gacgtatata tcgactggtg ttgtctgtta ttcatcgttg tttttcggtt agcttcgaaa     300

aaaaaataga gtaaaaacca ggaatttacc ctaaaaacaa gaaaaaataa gataaacgaa     360

aat                                                                   363


<210> 111
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tTPI1

<400> 111
gattaatata attatataaa aatattatct tcttttcttt atatctagtg ttatgtaaaa     60

taaattgatg actacggaaa gcttttttat attgtttctt tttcattctg agccacttaa    120

atttcgtgaa tgttcttgta agggacggta gatttacaag tgatacaaca aaaagcaagg    180

cgctttttct aataaaaaga agaaaagcat ttaacaattg aacacctcta tatcaacgaa    240

gaatattact ttgtctctaa atccttgtaa aatgtgtacg atctctatat gggttactca    300


<210> 112
<211> 299
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tMET25

<400> 112
gtgtgcgtaa tgagttgtaa aattatgtat aaacctactt tctctcacaa gtactatact     60

tttataaaac gaactttatt gaaatgaata tccttttttt cccttgttac atgtcgtgac    120

tcgtactttg aacctaaatt gttctaacat caaagaacag tgttaattcg cagtcgagaa    180

gaaaaatatg gtgaacaaga ctcatctact tcatgagact actttacgcc tcctataaag    240

ctgtcacact ggataaattt attgtaggac caagttacaa aagaggatga tggaggttt     299


<210> 113
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tDIT1

<400> 113
taaagtaaga gcgctacatt ggtctacctt tttgttcttt tacttaaaca ttagttagtt     60

cgttttcttt ttctcatttt tttatgtttc ccccccaaag ttctgatttt ataatatttt    120

atttcacaca attccattta acagaggggg aatagattct ttagcttaga aaattagtga    180

tcaatatata tttgcctttc ttttcatctt ttcagtgata ttaatggttt cgagacactg    240

caatggccct agttgtctaa gaggatagat gttactgtca aagatgatat tttgaatttc    300


<210> 114
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL3

<400> 114
gaagttttgt tagaaaataa atcatttttt aattgagcat tcttattcct attttattta     60

aatagtttta tgtattgtta gctacataca acagtttaaa tcaaattttc tttttcccaa    120

gtccaaaatg gaggtttatt ttgatgaccc gcatgcgatt atgttttgaa agtataagac    180

tacatacatg tacatatatt taaacatgta aacccgtcca ttatattgct tactttcttc    240

ttttttgccg ttttgacttg gacctctggt ttgctatttc cttacaatct ttgctacaat    300


<210> 115
<211> 304
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL3.sm

<400> 115
gaagttttta aagcattttt tagacacttc tcatttttct aagttttttt aaaatagttt     60

tatgtattta ctacgtatca caatttgaaa taattcatct tcccaaaaaa ctaagatttt    120

tatccttgtc acgatccgta accagtttat aatattttag agcttataca cgtacgtata    180

cacacgtgtc ggtacatgag aattacgttc aaaattattc actttttttt tctctgccgt    240

tttacttttg aactctgtct cgctatttcc ttacaatctt cgctacaata ccacttgccc    300

ttgg                                                                 304


<210> 116
<211> 299
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL3.sba

<400> 116
gaagttttct gacaaaaaca taacgttttt tccaatcatt tcttattttt ccggtttatt     60

taaatagttt ttatgtacta ttatacgtat gactatttaa cttaaattct tcctcccaag    120

aaatctccca agtttttcat tatcatggca tacaccacta tcagttacaa aatggtagct    180

caaccatata tatatctcta tatacacata taaatgcaaa caggtccaag tcaccgctca    240

ctgcagtttc ttttgccgtt ttgacttcga tctctgcttg gctattttct cacaatcct     299


<210> 117
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL41B

<400> 117
gcggattgag agcaaatcgt taagttcagg tcaagtaaaa attgatttcg aaaactaatt     60

tctcttatac aatcctttga ttggaccgtc atcctttcga atataagatt ttgttaagaa    120

tattttagac agagatctac tttatattta atatctagat attacataat ttcctctcta    180

ataaaatatc attaataaaa taaaaatgaa gcgatttgat tttgtgttgt caacttagtt    240

tgccgctatg cctcttgggt aatgctatta ttgaatcgaa gggctttatt atattaccct    300


<210> 118
<211> 301
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL41B.Sba

<400> 118
gcggattgcg agtgattttt tgagtacaga ccaagtaaaa ttgatctatg cataatcttt     60

tctcatccac aatccctaga atggaccgtc atcctttcta aaatgtttta ttaagaatat    120

ttaaagtgga agtcaggttt atatctatca attaaatatt acataatttc cccttaataa    180

aatactgtta ataaaataac gaaacgttca tagtttttca taaatagtcc tgatgcttac    240

tgcaccggaa cgtactgttt tagtgtattg ctcccttcat tgccattttt cctagttatt    300

g                                                                    301


<210> 119
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL15A

<400> 119
gctggttgat ggaaaatata attttattgg gcaaactttt gtttatctga tgtgttttat     60

actattatct ttttaattaa tgattctata tacaaacctg tatatttttt ctttaaccaa    120

tttttttttt tatagaccta gagctgtact tttattctgc tatcaagcaa acccctaccc    180

cctcttctca atcctcccct caggcagaac ttatctacct gtatcaagga gcggacgagg    240

gagtcctaat tgttctacgt ataccaatgc tagcagctta cataggtggt ggcactacca    300


<210> 120
<211> 299
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL15A.Sm

<400> 120
gctaattaga accatatata catcgataaa aacacttgaa tgtatttttc tttttcttct     60

tattttttca ttttccttcg ctttctatta gcgtgcgaat ctaaagtgtg cagcgctatc    120

tttgactctt tttttccttt agtgggaacg aacaatatta atcatgccaa gttaagtcat    180

tgaagaagtc agtagtatgt tattcggaga gaagaccctg ctatgtatct cagcctaccc    240

aaaaaatgaa ttgactcctc tcataacttg ttaatattcg gatgagcaca tcacgttcg     299


<210> 121
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tRPL15A.sba

<400> 121
gctggctgat gaaaaatata gttctgttgg gcaagcattt gtttacctag catctctttt     60

atactattat tatctttata tttgatgatt ttatatacaa gttgtatacc ttttctttaa    120

ccaatttttt tttttctaat ggtgcaccta gaagtacatt ttttctcacc aatagatagt    180

caagatactc ccagcctcta tggcgttacc acggagccga caagggaaag ctgcttatct    240

tacatatgca gatgccaagg cccgttacag gccgccttat tgatgtttag aaatagcttc    300


<210> 122
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tIDP1

<400> 122
tcgaatttac gtagcccaat ctaccacttt tttttttcat tttttaaagt gttatactta     60

gttatgctct aggataatga actacttttt tttttttttt tttactgtta tcataaatat    120

atatacctta ttgttgtttg caaccgtcgg ttaattcctt atcaaggttc cccaagttcg    180

gatcattacc atcaatttcc aacattttca tgagttcttc ttcttcatta ccgtgtttta    240

gggggctgtt cgcacttcta atagggctat caccaagctg ttctaattcg tccaaaagtt    300


<210> 123
<211> 290
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tIDP1.Sba

<400> 123
tctgatcttt ggaatgctcc atttactttt ttatttcata tttaggtacg atatatagtt     60

acgcttgaga actatgaact aataacttcc tttttctcta atacatactt acttcagctg    120

atggttgcaa acaacaataa aattccttgt cgaggttccc taaattagga tcattgccat    180

cgacttctaa cattttcatg agatcctcct cttcgttccc attctttaaa agactgtttc    240

cacttctaat agggttatcg cccaattgtt ctagttcgtc tagcaattcg               290


<210> 124
<211> 300
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of terminator tTEF1.sba

<400> 124
ggagattgat aggacttttc tagttgcata tcttttattt ttaaatctta tctattagtt     60

aattttttgt aatttatcct tatatatata gtttggttat tctaaaacat catttcagta    120

tctaaaacct ctcttattca ttaccttttt atttaatggt ttttgctaca ggcaaaaatt    180

taatggtttt tgctacaggc aaaaatcccg ccgtggactt attccacgtt aactcggtta    240

cagggtcatg aaccattttg tcaattatcg aaataacttc ttcaaaagtc cctcttactt    300


<210> 125
<211> 60
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of the secretion sequence added in 5â

<400> 125
atgcaattta gcacagtcgc atcagtagcc ttcgttgcct tggccaactt cgtggcagca     60


<210> 126
<211> 20
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of the secretion sequence added in N-ter

<400> 126
Met Gln Phe Ser Thr Val Ala Ser Val Ala Phe Val Ala Leu Ala Asn 
1               5                   10                  15      
Phe Val Ala Ala 
            20  

<210> 127
<211> 213
<212> DNA
<213> other sequences


<220> 
<223> nucleic acid sequence of the anchoring sequence added in 3â

<400> 127
ggatccgcca tttctcaaat cactgacggt caaatccaag ctactaccac tgctaccacc     60

gaagctacca ccactgctgc cccatcttcc accgttgaaa ctgtttctcc atccagcacc    120

gaaactatct ctcaacaaac tgaaaatggt gctgctaagg ccgctgtcgg tatgggtgcc    180

ggtgctctag ctgctgctgc tatgttgtta taa                                 213


<210> 128
<211> 68
<212> PRT
<213> other sequences


<220> 
<223> amino acid sequence of the anchoring sequence added in C-ter

<400> 128
Ala Ile Ser Gln Ile Thr Asp Gly Gln Ile Gln Ala Thr Thr Thr Ala 
1               5                   10                  15      
Thr Thr Glu Ala Thr Thr Thr Ala Ala Pro Ser Ser Thr Val Glu Thr 
            20                  25                  30          
Val Ser Pro Ser Ser Thr Glu Thr Ile Ser Gln Gln Thr Glu Asn Gly 
        35                  40                  45              
Ala Ala Lys Ala Ala Val Gly Met Gly Ala Gly Ala Leu Ala Ala Ala 
    50                  55                  60                  
Ala Met Leu Leu 
65              

