                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  ANTIBODIES TO GFRAL

<130>  BET 22P0816

<150>  GB2104553.9
<151>  2021-03-31

<150>  GB2107330.9
<151>  2021-05-21

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 VH domain nucleotide

<400>  1
caggttcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttcaat aactatggca tgcactgggt ccgccagggt      120

ccaggcaggg ggctggaatg ggtggctatt atatcatatg atggaacaac tcaatactct      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgttgtat      240

ctgcaaatga acagcctgag aactgaggac acggctctat attactgtgc gaaagaggcg      300

ggggatttct atggttcggg gaattatggg taccacaagt atggtttgga cgtctggggc      360

caagggacca cggtcaccgt ctcctcag                                         388


<210>  2
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 VH domain amino acid

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Gly Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Thr Thr Gln Tyr Ser Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr His 
            100                 105                 110         


Lys Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 HCDR1

<400>  3

Gly Phe Ala Phe Asn Asn Tyr Gly 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 HCDR2

<400>  4

Ile Ser Tyr Asp Gly Thr Thr Gln 
1               5               


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 HCDR3, QUEL-0103 HCDR3

<400>  5

Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr His 
1               5                   10                  15      


Lys Tyr Gly Leu Asp Val 
            20          


<210>  6
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 VL domain nucleotide

<400>  6

Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Ala Gly Gly Ala 
        35                  40                  45              


Gly Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Cys Thr Thr Gly Cys Cys Gly Gly Gly Cys Gly Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Gly Ala Cys Ala Thr Thr Ala Gly Cys Ala Ala Thr Thr Ala Thr 
                85                  90                  95      


Thr Thr Ala Gly Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys 
            100                 105                 110         


Ala Gly Ala Ala Gly Cys Cys Ala Gly Gly Gly Ala Ala Ala Ala Thr 
        115                 120                 125             


Thr Cys Cys Thr Ala Ala Gly Cys Thr Cys Cys Thr Gly Ala Thr Cys 
    130                 135                 140                 


Thr Ala Thr Gly Cys Thr Gly Cys Ala Thr Cys Cys Ala Cys Thr Thr 
145                 150                 155                 160 


Thr Gly Cys Ala Ala Thr Cys Ala Gly Gly Gly Gly Thr Cys Cys Cys 
                165                 170                 175     


Ala Thr Cys Thr Cys Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys 
            180                 185                 190         


Ala Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Ala Gly 
        195                 200                 205             


Ala Thr Thr Thr Cys Ala Cys Thr Cys Thr Cys Ala Cys Cys Ala Thr 
    210                 215                 220                 


Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys Cys Thr 
225                 230                 235                 240 


Gly Ala Ala Gly Ala Thr Gly Thr Thr Gly Cys Ala Ala Gly Thr Thr 
                245                 250                 255     


Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Ala Ala Ala Ala Thr Ala 
            260                 265                 270         


Thr Ala Gly Cys Ala Gly Thr Gly Cys Cys Cys Cys Gly Cys Thr Cys 
        275                 280                 285             


Ala Cys Thr Thr Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly Gly Ala 
    290                 295                 300                 


Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Gly Ala Thr Cys Ala Ala 
305                 310                 315                 320 


Ala Cys 
        


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 VL domain amino acid

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Gln Lys Tyr Ser Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 LCDR1, QUEL-0102 LCDR1, QUEL-0103 LCDR1, QUEL-0104 
       LCDR1, QUEL-0105 LCDR1

<400>  8

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  9

<400>  9
000

<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0101 LCDR3

<400>  10

Gln Lys Tyr Ser Ser Ala Pro Leu Thr 
1               5                   


<210>  11
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 VH domain nucleotide

<400>  11
caggtccagc ttgtgcagtc tggggctgag gtgaaggagc ctggggcctc agtgagggtt       60

tcctgtaagg cttctggata caccttcatt agtcacgcta tacattgggt gcgccaggcc      120

cccggacaaa gacttgagtg gatgggatgg atcaacgctg tcaatggaaa cacaaaatat      180

tcacagaagt tccaggacag agtcaccttt accagggaca catccgcgag cacagcctac      240

atggacctga acagcctgag agctgaagac acggctcttt attactgtgc gagagaggga      300

tacacctatg gtgtccacta ctcgtacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcgt cag                                                         373


<210>  12
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 VH domain amino acid

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser His 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Val Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Phe Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Thr Tyr Gly Val His Tyr Ser Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 HCDR1

<400>  13

Gly Tyr Thr Phe Ile Ser His Ala 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 HCDR2

<400>  14

Ile Asn Ala Val Asn Gly Asn Thr 
1               5               


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 HCDR3

<400>  15

Ala Arg Glu Gly Tyr Thr Tyr Gly Val His Tyr Ser Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  16
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 VL domain nucleotide

<400>  16
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagttc caatatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagtcctcaa actcctcatt tatggtaaca acaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caactctggc acctcagcct ccctggccat cactgggctc      240

cagcctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttat      300

tgggtgttcg gcggagggac caagctgacc gtcctag                               337


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 VL domain amino acid

<400>  17

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Val Leu Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Asn Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Tyr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 LCDR1

<400>  18

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  19

<400>  19
000

<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0201 LCDR3

<400>  20

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Trp Val 
1               5                   10          


<210>  21
<211>  355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 VH domain nucleotide

<400>  21
gaggtgcaac tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgcgcag cttctggatt cacctttagt aactcttgga tgaactgggt ccgccagact      120

ccagggaagg ggctggagtg ggtggccaat atagaccaag atggagatca gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtct attactgtgc gagagaaata      300

actggaacta catttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  22
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 VH domain amino acid

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asp Gln Asp Gly Asp Gln Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ile Thr Gly Thr Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 HCDR1, QUEL-0302 HCDR1

<400>  23

Gly Phe Thr Phe Ser Asn Ser Trp 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 HCDR2

<400>  24

Ile Asp Gln Asp Gly Asp Gln Lys 
1               5               


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 HCDR3

<400>  25

Ala Arg Glu Ile Thr Gly Thr Thr Phe Asp Tyr 
1               5                   10      


<210>  26
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 VL domain nucleotide

<400>  26
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatattg taaactggta ccagcaactc      120

ccaggaacgg cccccaaact cctcatctct agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtaca acatgggatg acagcctgga tggtccggtg      300

ttcggcggag ggaccaagct gaccgtcctg g                                     331


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 VL domain amino acid

<400>  27

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asp Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 LCDR1

<400>  28

Ser Ser Asn Ile Gly Ser Asn Ile 
1               5               


<210>  29

<400>  29
000

<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0301 LCDR3

<400>  30

Thr Thr Trp Asp Asp Ser Leu Asp Gly Pro Val 
1               5                   10      


<210>  31
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(394)
<223>  human GFRAL

<400>  31

Met Ile Val Phe Ile Phe Leu Ala Met Gly Leu Ser Leu Glu Asn Glu 
1               5                   10                  15      


Tyr Thr Ser Gln Thr Asn Asn Cys Thr Tyr Leu Arg Glu Gln Cys Leu 
            20                  25                  30          


Arg Asp Ala Asn Gly Cys Lys His Ala Trp Arg Val Met Glu Asp Ala 
        35                  40                  45              


Cys Asn Asp Ser Asp Pro Gly Asp Pro Cys Lys Met Arg Asn Ser Ser 
    50                  55                  60                  


Tyr Cys Asn Leu Ser Ile Gln Tyr Leu Val Glu Ser Asn Phe Gln Phe 
65                  70                  75                  80  


Lys Glu Cys Leu Cys Thr Asp Asp Phe Tyr Cys Thr Val Asn Lys Leu 
                85                  90                  95      


Leu Gly Lys Lys Cys Ile Asn Lys Ser Asp Asn Val Lys Glu Asp Lys 
            100                 105                 110         


Phe Lys Trp Asn Leu Thr Thr Arg Ser His His Gly Phe Lys Gly Met 
        115                 120                 125             


Trp Ser Cys Leu Glu Val Ala Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Ser Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Pro Cys Asp Leu Lys Gln Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Ile Pro Phe Asn Ile Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Ala Leu His Ser Lys 
        195                 200                 205             


Thr Cys Ala Val Asn Met Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


Arg Ser Cys Gln Asn Asp Glu Leu Cys Arg Arg His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Ser Lys Cys Trp Gln Arg Val Thr Arg Lys Cys His Glu Asp Glu 
                245                 250                 255     


Asn Cys Ile Ser Thr Leu Ser Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Asp Asp Cys Lys Ala Ala Tyr Ile Asp Ile Leu Gly Thr Val Leu Gln 
        275                 280                 285             


Val Gln Cys Thr Cys Arg Thr Ile Thr Gln Ser Glu Glu Ser Leu Cys 
    290                 295                 300                 


Lys Ile Phe Gln His Met Leu His Arg Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Leu Ser Asn Val Lys Gly Met Ala Leu Tyr Thr Arg Lys His Ala 
                325                 330                 335     


Asn Lys Ile Thr Leu Thr Gly Phe His Ser Pro Phe Asn Gly Glu Val 
            340                 345                 350         


Ile Tyr Ala Ala Met Cys Met Thr Val Thr Cys Gly Ile Leu Leu Leu 
        355                 360                 365             


Val Met Val Lys Leu Arg Thr Ser Arg Ile Ser Ser Lys Ala Arg Asp 
    370                 375                 380                 


Pro Ser Pro Ile Gln Ile Pro Gly Glu Leu 
385                 390                 


<210>  32
<211>  393
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(393)
<223>  mouse GFRAL

<400>  32

Met Leu Val Phe Ile Phe Leu Ala Val Thr Leu Ser Ser Glu Asn Glu 
1               5                   10                  15      


Ser Ser Ser Gln Thr Asn Asp Cys Ala His Leu Ile Gln Lys Cys Leu 
            20                  25                  30          


Ile Asp Ala Asn Gly Cys Glu Gln Ser Trp Arg Ser Met Glu Asp Thr 
        35                  40                  45              


Cys Leu Thr Pro Gly Asp Ser Cys Lys Ile Asn Asn Ser Leu His Cys 
    50                  55                  60                  


Asn Leu Ser Ile Gln Ala Leu Val Glu Lys Asn Phe Gln Phe Lys Glu 
65                  70                  75                  80  


Cys Leu Cys Met Asp Asp Leu His Cys Thr Val Asn Lys Leu Phe Gly 
                85                  90                  95      


Lys Lys Cys Thr Asn Lys Thr Asp Asn Met Glu Lys Asp Asn Lys Asp 
            100                 105                 110         


Lys Trp Asn Leu Thr Thr Thr Pro Phe Tyr His Gly Phe Lys Gln Met 
        115                 120                 125             


Gln Ser Cys Leu Glu Val Thr Glu Ala Cys Val Gly Asp Val Val Cys 
    130                 135                 140                 


Asn Ala Gln Leu Ala Leu Tyr Leu Lys Ala Cys Ser Ala Asn Gly Asn 
145                 150                 155                 160 


Leu Cys Asp Val Lys His Cys Gln Ala Ala Ile Arg Phe Phe Tyr Gln 
                165                 170                 175     


Asn Met Pro Phe Asn Thr Ala Gln Met Leu Ala Phe Cys Asp Cys Ala 
            180                 185                 190         


Gln Ser Asp Ile Pro Cys Gln Gln Ser Lys Glu Thr Leu His Ser Lys 
        195                 200                 205             


Pro Cys Ala Leu Asn Ile Val Pro Pro Pro Thr Cys Leu Ser Val Ile 
    210                 215                 220                 


His Thr Cys Arg Asn Asp Glu Leu Cys Arg Thr His Tyr Arg Thr Phe 
225                 230                 235                 240 


Gln Thr Glu Cys Trp Pro His Ile Thr Gly Lys Cys His Glu Asp Glu 
                245                 250                 255     


Thr Cys Ile Ser Met Leu Gly Lys Gln Asp Leu Thr Cys Ser Gly Ser 
            260                 265                 270         


Glu Ser Cys Arg Ala Ala Phe Leu Gly Thr Phe Gly Thr Val Leu Gln 
        275                 280                 285             


Val Pro Cys Ala Cys Arg Gly Val Thr Gln Ala Glu Glu His Val Cys 
    290                 295                 300                 


Met Ile Phe Gln His Met Leu His Ser Lys Ser Cys Phe Asn Tyr Pro 
305                 310                 315                 320 


Thr Pro Asn Val Lys Asp Ile Ser Ser Tyr Glu Lys Lys Asn Ser Lys 
                325                 330                 335     


Glu Ile Thr Leu Thr Gly Phe Asn Ser Phe Phe Asn Gly Glu Leu Leu 
            340                 345                 350         


Tyr Val Val Val Cys Met Ala Val Thr Cys Gly Ile Leu Phe Leu Val 
        355                 360                 365             


Met Leu Lys Leu Arg Ile Gln Ser Glu Lys Arg Asp Pro Ser Ser Ile 
    370                 375                 380                 


Glu Ile Ala Gly Gly Val Ile Ile Gln 
385                 390             


<210>  33
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(990)
<223>  Human Heavy Chain Constant Region (IGHG1*01) Nucleotide Sequence

<400>  33
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  34
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  Human Heavy Chain Constant Region (IGHG1*01) Protein Sequence 
       (P01857)

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  35
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(990)
<223>  Human Heavy Chain Constant Region (IGHG1*02 or IGHG1*05) 
       Nucleotide Sequence

<400>  35
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  36
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  Human Heavy Chain Constant Region (IGHG1*02) Protein Sequence

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  37
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(990)
<223>  Human Heavy Chain Constant Region (IGHG1*03) Nucleotide Sequence 
       (Y14737)

<400>  37
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  38
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  Human Heavy Chain Constant Region (IGHG1*03) Protein Sequence

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  39
<211>  990
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Heavy Chain Constant Region (IGHG1*04) Nucleotide Sequence

<400>  39
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acatcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  40
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(330)
<223>  Human Heavy Chain Constant Region (IGHG1*04) Protein Sequence

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  41
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Disabled Human IGHG1*01 Heavy Chain Constant Region Nucleotide 
       Sequence.

<400>  41
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agtggagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cgcgggggca      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  42
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Disabled Human IGHG1*01 Heavy Chain Constant Region Amino Acid 
       Sequence.

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  43
<211>  978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(978)
<223>  Human Heavy Chain Constant Region (IGHG2*01 or IGHG2*03 or 
       IGHG2*05) Nucleotide Sequence

<400>  43
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  44
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(326)
<223>  Human Heavy Chain Constant Region (IGHG2*01) Protein Sequence

<400>  44

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  45
<211>  978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(978)
<223>  Human Heavy Chain Constant Region (IGHG2*02) Nucleotide Sequence

<400>  45
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgacctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

atggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt cgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  46
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(326)
<223>  Human Heavy Chain Constant Region (IGHG2*02) Protein Sequence

<400>  46

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  47
<211>  978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(978)
<223>  Human Heavy Chain Constant Region (IGHG2*04) Nucleotide Sequence

<400>  47
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  48
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(326)
<223>  Human Heavy Chain Constant Region (IGHG2*04) Protein Sequence

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  49
<211>  978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(978)
<223>  Human Heavy Chain Constant Region (IGHG2*06) Nucleotide Sequence

<400>  49
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt cgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatctc cgtggagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc      960

tccctgtctc cgggtaaa                                                    978


<210>  50
<211>  326
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(326)
<223>  Human Heavy Chain Constant Region (IGHG2*06) Protein Sequence

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  51
<211>  981
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(981)
<223>  Human Heavy Chain Constant Region (IGHG4*01 or IGHG4*04) 
       Nucleotide Sequence

<400>  51
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  52
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(327)
<223>  Human Heavy Chain Constant Region (IGHG4*01) Protein Sequence 
       (P01861)

<400>  52

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  53
<211>  981
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(981)
<223>  Human Heavy Chain Constant Region (IGHG4*02) Nucleotide Sequence

<400>  53
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccgtgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcgtgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  54
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(327)
<223>  Human Heavy Chain Constant Region (IGHG4*02) Protein Sequence

<400>  54

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  55
<211>  981
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(981)
<223>  Human Heavy Chain Constant Region (IGHG4*03) Nucleotide Sequence

<400>  55
gcttccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcaggagggg      900

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  56
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(327)
<223>  Human Heavy Chain Constant Region (IGHG4*03) Protein Sequence

<400>  56

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  57
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Heavy Chain Constant Region (IGHG4-PE) Nucleotide Sequence 
       Version A

<400>  57
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacggccg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcgcctgaat ttgagggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtca tcgatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggatcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  58
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Heavy Chain Constant Region (IGHG4-PE) Nucleotide Sequence 
       Version B

<400>  58
gcctccacca agggacctag cgtgttccct ctcgccccct gttccaggtc cacaagcgag       60

tccaccgctg ccctcggctg tctggtgaaa gactactttc ccgagcccgt gaccgtctcc      120

tggaatagcg gagccctgac ctccggcgtg cacacatttc ccgccgtgct gcagagcagc      180

ggactgtata gcctgagcag cgtggtgacc gtgcccagct ccagcctcgg caccaaaacc      240

tacacctgca acgtggacca caagccctcc aacaccaagg tggacaagcg ggtggagagc      300

aagtacggcc ccccttgccc tccttgtcct gcccctgagt tcgagggagg accctccgtg      360

ttcctgtttc cccccaaacc caaggacacc ctgatgatct cccggacacc cgaggtgacc      420

tgtgtggtcg tggacgtcag ccaggaggac cccgaggtgc agttcaactg gtatgtggac      480

ggcgtggagg tgcacaatgc caaaaccaag cccagggagg agcagttcaa ttccacctac      540

agggtggtga gcgtgctgac cgtcctgcat caggattggc tgaacggcaa ggagtacaag      600

tgcaaggtgt ccaacaaggg actgcccagc tccatcgaga agaccatcag caaggctaag      660

ggccagccga gggagcccca ggtgtatacc ctgcctccta gccaggaaga gatgaccaag      720

aaccaagtgt ccctgacctg cctggtgaag ggattctacc cctccgacat cgccgtggag      780

tgggagagca atggccagcc cgagaacaac tacaaaacaa cccctcccgt gctcgatagc      840

gacggcagct tctttctcta cagccggctg acagtggaca agagcaggtg gcaggagggc      900

aacgtgttct cctgttccgt gatgcacgag gccctgcaca atcactacac ccagaagagc      960

ctctccctgt ccctgggcaa g                                                981


<210>  59
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Heavy Chain Constant Region (IGHG4-PE) Nucleotide Sequence 
       Version C

<400>  59
gccagcacca agggcccttc cgtgttcccc ctggcccctt gcagcaggag cacctccgaa       60

tccacagctg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      120

tggaacagcg gcgctctgac atccggcgtc cacacctttc ctgccgtcct gcagtcctcc      180

ggcctctact ccctgtcctc cgtggtgacc gtgcctagct cctccctcgg caccaagacc      240

tacacctgta acgtggacca caaaccctcc aacaccaagg tggacaaacg ggtcgagagc      300

aagtacggcc ctccctgccc tccttgtcct gcccccgagt tcgaaggcgg acccagcgtg      360

ttcctgttcc ctcctaagcc caaggacacc ctcatgatca gccggacacc cgaggtgacc      420

tgcgtggtgg tggatgtgag ccaggaggac cctgaggtcc agttcaactg gtatgtggat      480

ggcgtggagg tgcacaacgc caagacaaag ccccgggaag agcagttcaa ctccacctac      540

agggtggtca gcgtgctgac cgtgctgcat caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtca gcaataaggg actgcccagc agcatcgaga agaccatctc caaggctaaa      660

ggccagcccc gggaacctca ggtgtacacc ctgcctccca gccaggagga gatgaccaag      720

aaccaggtga gcctgacctg cctggtgaag ggattctacc cttccgacat cgccgtggag      780

tgggagtcca acggccagcc cgagaacaat tataagacca cccctcccgt cctcgacagc      840

gacggatcct tctttctgta ctccaggctg accgtggata agtccaggtg gcaggaaggc      900

aacgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagtcc      960

ctgagcctgt ccctgggaaa g                                                981


<210>  60
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Heavy Chain Constant Region (IGHG4-PE) Protein Sequence

<400>  60

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  61
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Inactivated Human Heavy Chain Constant Region (IGHG4) Nucleotide 
       Sequence

<400>  61
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacggccg ccctgggctg cctggtcaag gactacttcc ccgaaccagt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcgcctccag ttgcgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtca tcgatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggatcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctgggtaa a                                                981


<210>  62
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Inactivated Human Heavy Chain Constant Region (IGHG4) Protein 
       Sequence

<400>  62

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  63
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Human Ck Light Chain Constant Region (IGKC*01) Nucleotide 
       Sequence

<400>  63
cgtacggtgg ccgctccctc cgtgttcatc ttcccacctt ccgacgagca gctgaagtcc       60

ggcaccgctt ctgtcgtgtg cctgctgaac aacttctacc cccgcgaggc caaggtgcag      120

tggaaggtgg acaacgccct gcagtccggc aactcccagg aatccgtgac cgagcaggac      180

tccaaggaca gcacctactc cctgtcctcc accctgaccc tgtccaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaagtgacc caccagggcc tgtctagccc cgtgaccaag      300

tctttcaacc ggggcgagtg t                                                321


<210>  64
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Ck Light Chain Constant Region (IGKC*01) Amino Acid Sequence

<400>  64

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  65
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Ck Light Chain Constant Region (IGKC*02) Nucleotide Sequence

<400>  65
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggag      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgccgg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  66
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Ck Light Chain Constant Region (IGKC*02) Amino Acid Sequence

<400>  66

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Glu Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Gly Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  67
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Ck Light Chain Constant Region (IGKC*03) Nucleotide Sequence

<400>  67
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

cggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggag      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  68
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Ck Light Chain Constant Region (IGKC*03) Amino Acid Sequence

<400>  68

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Arg Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Glu Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  69
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Ck Light Chain Constant Region (IGKC*04) Nucleotide Sequence

<400>  69
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaac tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  70
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Ck Light Chain Constant Region (IGKC*04) Amino Acid Sequence

<400>  70

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  71
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  Ck Light Chain Constant Region (IGKC*05) Nucleotide Sequence

<400>  71
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcaac accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg c                                                321


<210>  72
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Ck Light Chain Constant Region (IGKC*05) Amino Acid Sequence

<400>  72

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  73
<211>  312
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(312)
<223>  Cl Light Chain Constant Region (IGLC1*01) Nucleotide Sequence 
       (ENST00000390321.2

<400>  73
cccaaggcca accccacggt cactctgttc ccgccctcct ctgaggagct ccaagccaac       60

aaggccacac tagtgtgtct gatcagtgac ttctacccgg gagctgtgac agtggcttgg      120

aaggcagatg gcagccccgt caaggcggga gtggagacga ccaaaccctc caaacagagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac      240

agaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agtggcccct      300

acagaatgtt ca                                                          312


<210>  74
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(104)
<223>  Cl Light Chain Constant Region (IGLC1*01) Amino Acid Sequence 
       (A0A075B6K8)

<400>  74

Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210>  75
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC1*02) Nucleotide Sequence 
       Version A

<400>  75
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  76
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  CL Light Chain Constant Region (IGLC1*02) Nucleotide Sequence 
       Version B

<400>  76
ggtcagccca aggccaaccc cactgtcact ctgttcccgc cctcctctga ggagctccaa       60

gccaacaagg ccacactagt gtgtctgatc agtgacttct acccgggagc tgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gcgggagtgg agaccaccaa accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  77
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC1*02) Amino Acid Sequence

<400>  77

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  78
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC2*01) Nucleotide Sequence 
       Version A

<400>  78
ggccagccta aggccgctcc ttctgtgacc ctgttccccc catcctccga ggaactgcag       60

gctaacaagg ccaccctcgt gtgcctgatc agcgacttct accctggcgc cgtgaccgtg      120

gcctggaagg ctgatagctc tcctgtgaag gccggcgtgg aaaccaccac cccttccaag      180

cagtccaaca acaaatacgc cgcctcctcc tacctgtccc tgacccctga gcagtggaag      240

tcccaccggt cctacagctg ccaagtgacc cacgagggct ccaccgtgga aaagaccgtg      300

gctcctaccg agtgctcc                                                    318


<210>  79
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC2*01) Nucleotide Sequence 
       Version B

<400>  79
ggccagccta aagctgcccc cagcgtcacc ctgtttcctc cctccagcga ggagctccag       60

gccaacaagg ccaccctcgt gtgcctgatc tccgacttct atcccggcgc tgtgaccgtg      120

gcttggaaag ccgactccag ccctgtcaaa gccggcgtgg agaccaccac accctccaag      180

cagtccaaca acaagtacgc cgcctccagc tatctctccc tgacccctga gcagtggaag      240

tcccaccggt cctactcctg tcaggtgacc cacgagggct ccaccgtgga aaagaccgtc      300

gcccccaccg agtgctcc                                                    318


<210>  80
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cl Light Chain Constant Region (IGLC1*02) Amino Acid Sequence

<400>  80

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  81
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC2*02 or IGLC2*03) Nucleotide 
       Sequence

<400>  81
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  82
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC2*02) Amino Acid Sequence

<400>  82

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  83
<211>  312
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(312)
<223>  Cl Light Chain Constant Region (IGLC3*01) Nucleotide Sequence

<400>  83
cccaaggctg ccccctcggt cactctgttc ccaccctcct ctgaggagct tcaagccaac       60

aaggccacac tggtgtgtct cataagtgac ttctacccgg gagccgtgac agttgcctgg      120

aaggcagata gcagccccgt caaggcgggg gtggagacca ccacaccctc caaacaaagc      180

aacaacaagt acgcggccag cagctacctg agcctgacgc ctgagcagtg gaagtcccac      240

aaaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agttgcccct      300

acggaatgtt ca                                                          312


<210>  84
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(104)
<223>  Cl Light Chain Constant Region (IGLC3*01) Amino Acid Sequence

<400>  84

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
1               5                   10                  15      


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
            20                  25                  30          


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
        35                  40                  45              


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
    50                  55                  60                  


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
65                  70                  75                  80  


Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
                85                  90                  95      


Thr Val Ala Pro Thr Glu Cys Ser 
            100                 


<210>  85
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC3*02) Nucleotide Sequence

<400>  85
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccggggcc agtgacagtt      120

gcctggaagg cagatagcag ccccgtcaag gcgggggtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacgg aatgttca                                                    318


<210>  86
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC1*02) Amino Acid Sequence

<400>  86

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Pro Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  87
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC3*03) Nucleotide Sequence

<400>  87
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  88
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC3*03) Amino Acid Sequence

<400>  88

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  89
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC3*04) Nucleotide Sequence

<400>  89
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  90
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC3*04) Amino Acid Sequence

<400>  90

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  91
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC6*01) Nucleotide Sequence

<400>  91
ggtcagccca aggctgcccc atcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgcctgatc agtgacttct acccgggagc tgtgaaagtg      120

gcctggaagg cagatggcag ccccgtcaac acgggagtgg agaccaccac accctccaaa      180

cagagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgttca                                                    318


<210>  92
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC6*01) Amino Acid Sequence

<400>  92

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  93
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC7*01 or IGLC7*02) Nucleotide 
       Sequence

<400>  93
ggtcagccca aggctgcccc atcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  94
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC7*01) Amino Acid Sequence

<400>  94

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  95
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(318)
<223>  Cl Light Chain Constant Region (IGLC7*03) Nucleotide Sequence

<400>  95
ggtcagccca aggctgcccc ctcggtcact ctgttcccac cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcgta agtgacttca acccgggagc cgtgacagtg      120

gcctggaagg cagatggcag ccccgtcaag gtgggagtgg agaccaccaa accctccaaa      180

caaagcaaca acaagtatgc ggccagcagc tacctgagcc tgacgcccga gcagtggaag      240

tcccacagaa gctacagctg ccgggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctgcag aatgctct                                                    318


<210>  96
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Cl Light Chain Constant Region (IGLC7*03) Amino Acid Sequence

<400>  96

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Asn Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  97
<211>  388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 VH domain nucleotide

<400>  97
caggttcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcaaa aactatggca tgcactgggt ccgccagggt      120

ccaggcaagg ggctggagtg ggtggcaatt atatcatatg atggaacatt taaatattct      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgttgtat      240

ctgcaaatga acagcctgag aactgaggac acggctctgt attactgtgc gaaagaggcg      300

ggggatttct atggttcggg gagttatggg taccacaagt atggtttgga cgtctggggc      360

caagggacca cggtcaccgt ctcctcag                                         388


<210>  98
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 VH domain amino acid

<400>  98

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Lys Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Thr Phe Lys Tyr Ser Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Ser Tyr Gly Tyr His 
            100                 105                 110         


Lys Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 HCDR1

<400>  99

Gly Phe Thr Leu Lys Asn Tyr Gly 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 HCDR2

<400>  100

Ile Ser Tyr Asp Gly Thr Phe Lys 
1               5               


<210>  101
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 HCDR3

<400>  101

Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Ser Tyr Gly Tyr His 
1               5                   10                  15      


Lys Tyr Gly Leu Asp Val 
            20          


<210>  102
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 VL domain nucleotide

<400>  102
gacgtccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca ggacattagc aattatttag cctggtatca gcagcaacca      120

gggaaagttc ctaaactcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caagttatta ctgtcaaaaa tataacagtg ccccgctcac tttcggcgga      300

gggaccgagg tggagatcaa gc                                               322


<210>  103
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 VL domain amino acid

<400>  103

Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Glu Val Glu Ile Lys 
            100                 105         


<210>  104
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0102 LCDR3, QUEL-0103 LCDR3, QUEL-0104 LCDR3, QUEL-0105 
       LCDR3

<400>  104

Gln Lys Tyr Asn Ser Ala Pro Leu Thr 
1               5                   


<210>  105
<211>  388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0103 VH domain nucleotide

<400>  105
caggttcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat aactatggca tgcactgggt ccgccagggt      120

ccaggcaagg ggctggagtg ggtggctatt atatcatatg atggaacaac taaatactct      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgttgtat      240

ctacaaatga acagcctgag aactgaggac acggctctgt atttctgtgc gaaagaggcg      300

ggggatttct atggttcggg gaattatggg taccacaagt atggtttgga cgtctggggc      360

caagggacca cggtcaccgt ctcctcag                                         388


<210>  106
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0103 VH domain amino acid

<400>  106

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Thr Thr Lys Tyr Ser Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr His 
            100                 105                 110         


Lys Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0103 HCDR1, QUEL-0104 HCDR1

<400>  107

Gly Phe Thr Phe Asn Asn Tyr Gly 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0103 HCDR2, QUEL-0104 HCDR2, QUEL-0105 HCDR2

<400>  108

Ile Ser Tyr Asp Gly Thr Thr Lys 
1               5               


<210>  109
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0103 VL domain nucleotide

<400>  109
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca ggacattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caagttatta ctgtcaaaaa tataacagtg ccccgctcac tttcggcgga      300

gggaccgagg tggagatcaa gc                                               322


<210>  110
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0103 VL domain amino acid

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Glu Val Glu Ile Lys 
            100                 105         


<210>  111
<211>  388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0104 VH domain nucleotide

<400>  111
caggttcaac tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat aactatggca tgcactgggt ccgccagggt      120

ccaggcaagg ggctggagtg ggtggctatt atatcatatg atggaacaac taaatactct      180

gtagactccg tgaagggccg attcactatc tccagagaca attccaagaa cacgttgtat      240

atgcaaatgg acagcctgag aacggaggac acggctctgt attactgtgc gaaggaggcg      300

ggggatttct atggttcggg gaattatggg tacctctact atggtttgga cgtctggggc      360

caagggacca cggtcaccgt ctcctcag                                         388


<210>  112
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0104 VH domain amino acid

<400>  112

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Thr Thr Lys Tyr Ser Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Met Gln Met Asp Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr Leu 
            100                 105                 110         


Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  113
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0104 HCDR3

<400>  113

Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr Leu 
1               5                   10                  15      


Tyr Tyr Gly Leu Asp Val 
            20          


<210>  114
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0104 VL domain nucleotide

<400>  114
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca ggacattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaacctcct gatctttgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataatagtg ccccgctcac tttcggcgga      300

gggaccaagg tggagatcaa cc                                               322


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0104 VL domain amino acid

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Asn Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Asn 
            100                 105         


<210>  116
<211>  388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0105 VH domain nucleotide

<400>  116
caggtgcaac tggtggagtc tgggggagac gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggttt caccttcaaa aactatggca tgcactgggt ccgccagggt      120

ctaggcaagg ggctggagtg ggtggctatt atatcatatg atggaacaac taaatactct      180

gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgttgtat      240

ctgcaaatga acagcctgag aactgaggac acggctctgt attactgtgc gaaagaggcg      300

ggggatttct atggttcggg gaattatggg tactactact atggtttgga cgtctggggc      360

caagggacca cggtcaccgt ctcctcag                                         388


<210>  117
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0105 VH domain amino acid

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Gly Leu Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Tyr Asp Gly Thr Thr Lys Tyr Ser Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0105 HCDR1

<400>  118

Gly Phe Thr Phe Lys Asn Tyr Gly 
1               5               


<210>  119
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0105 HCDR3

<400>  119

Ala Lys Glu Ala Gly Asp Phe Tyr Gly Ser Gly Asn Tyr Gly Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Leu Asp Val 
            20          


<210>  120
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0105 VL domain nucleotide

<400>  120
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgaatca ggacattagc aattatttag cctggtatca gcagaaacca      120

gggaaatttc ctaagctcct gatctatgct gcatccactt tgcaatcagg ggtcccatct      180

cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataacagtg ccccgctcac tttcggcgga      300

gggaccaagg tggagatcaa ac                                               322


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0105 VL domain amino acid

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Phe Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  122
<211>  355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 VH domain nucleotide

<400>  122
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactcttgga tgaactgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggcagtga gagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca actccaagaa ctcactgtct      240

ctgcaaatga acagcctgag agccgaggac acggctatct attactgtgc gagagaaata      300

actggaacct actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  123
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 VH domain amino acid

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ile Thr Gly Thr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 HCDR2

<400>  124

Ile Asn Gln Asp Gly Ser Glu Arg 
1               5               


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 HCDR3

<400>  125

Ala Arg Glu Ile Thr Gly Thr Tyr Phe Asp Tyr 
1               5                   10      


<210>  126
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 VL domain nucleotide

<400>  126
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga aataattatg tatactggta ccaacagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgaata ttactgtgca gcatgggatg acagcctgag tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  127
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 VL domain amino acid

<400>  127

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 LCDR1

<400>  128

Ser Ser Asn Ile Gly Asn Asn Tyr 
1               5               


<210>  129

<400>  129
000

<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0302 LCDR3

<400>  130

Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      


<210>  131
<211>  355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 VH domain nucleotide

<400>  131
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac atagaccaag atggaagtga gaaatactat      180

gtggactctt tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac tcggctgtgt attactgtgc gagagagcta      300

actggaacta cttttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  132
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 VH domain amino acid

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asp Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Thr Gly Thr Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  133
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 HCDR1, QUEL-0304 HCDR1

<400>  133

Gly Phe Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 HCDR2

<400>  134

Ile Asp Gln Asp Gly Ser Glu Lys 
1               5               


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 HCDR3

<400>  135

Ala Arg Glu Leu Thr Gly Thr Thr Phe Asp Tyr 
1               5                   10      


<210>  136
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 VL domain nucleotide

<400>  136
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatacta taaactggta ccaactgctc      120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  137
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 VL domain amino acid

<400>  137

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Ile Asn Trp Tyr Gln Leu Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 LCDR1, QUEL-0304 LCDR1

<400>  138

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0303 LCDR3

<400>  139

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  140
<211>  355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 VH domain nucleotide

<400>  140
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacatttagt aactattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac atgaaccatg atggaagtga taaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagag tttaatgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtat attactgtgc gagagatcgg      300

actggaacta tctttgacta ctggggccag ggaaccttgg tcaccgtctc ctcag           355


<210>  141
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 VH domain amino acid

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Met Asn His Asp Gly Ser Asp Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Leu Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Thr Gly Thr Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 HCDR2

<400>  142

Met Asn His Asp Gly Ser Asp Lys 
1               5               


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 HCDR3

<400>  143

Ala Arg Asp Arg Thr Gly Thr Ile Phe Asp Tyr 
1               5                   10      


<210>  144
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 VL domain nucleotide

<400>  144
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcaactc      120

ccaggaacgg cccccaaagt cctcatctat agtaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctaatta ttactgtgca acatgggatg acagcctgaa tggtccggtg      300

ttcggcggag ggaccaagct gaccgtccta g                                     331


<210>  145
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 VL domain amino acid

<400>  145

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asn Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QUEL-0304 LCDR3

<400>  146

Ala Thr Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


