                         SEQUENCE LISTING

<110>  DIACCURATE
 
<120>  ANTI-PLA2G1B MONOCLONAL ANTIBODIES AND USES THEREOF

<130>  B3517PC00

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mAb1 variable light chain region (mAb1-VL)

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      


Arg Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mAb1 constant light chain region Ck

<400>  2

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  3
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of mAb1 variable light chain region (mAb1-VL)

<400>  3
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gcactggtac      120

cagcagaaac cgggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggaga ctgatgatgt tgcaacctat tactgtcagc aaagtagtag ggatctgttc      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  4
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of mAb1 constant light chain region Ck

<400>  4
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct       60

ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccagagacat caatgtcaag      120

tggaagattg atggcagtga acgacaaaat ggtgtcctga acagttggac tgatcaggac      180

agcaaagaca gcacctacag catgagcagc accctcacat tgaccaagga cgagtatgaa      240

cgacataaca gctatacctg tgaggccact cacaagacat caacttcacc catcgtcaag      300

agcttcaaca ggaatgagtg t                                                321


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mAb1 variable heavy chain region (mAb1-VH)

<400>  5

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Val Ser Leu Asn Cys Thr Val Ser Gly His Ser Ile Thr Asp Asp 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg Leu Val Ser Gly Ser Lys Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Thr Ser Ser Gly Asn Thr Asp Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Ile Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu His Leu Ser Ser Val Thr Ala Glu Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Thr Asp Gly Asp Phe Tyr Phe Glu Lys Trp Gly 
            100                 105                 110         


Arg Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mAb1 constant heavy chain region

<400>  6

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 


<210>  7
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of mAb1 variable heavy chain region (mAb1-VH)

<400>  7
gatgtacagc ttcaggagtc aggacctggc ctggtgaagc cttctcagac agtgtccctc       60

aactgcactg tctctggcca ctctatcact gatgataatt actattggag ctggatccgg      120

ctggtttcag gaagcaaact ggagtggata gggtacataa cctccagtgg taacactgac      180

aacaatcctt ctctcaaaag tcgcatctcc gtcacccggg acatttccaa gaaccagttc      240

ttcctgcact tgagctctgt gactgctgaa gattcagcca catattactg tgcaagagat      300

tcaactgatg gtgactttta ctttgaaaaa tggggccgag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  8
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of mAb1 constant heavy chain region

<400>  8
gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggaga tacaagtggc       60

tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc      120

tggaactctg gatccctgtc cagtggtgtg cacaccttcc cagctgtcct gcagtctgac      180

ctctacaccc tcagcagctc agtgactgta acctcgagca cctggcccag ccagtccatc      240

acctgcaatg tggcccaccc ggcaagcagc accaaggtgg acaagaaaat tgagcccaga      300

gggcccacaa tcaagccctg tcctccatgc aaatgcccag cacctaacct cttgggtgga      360

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cctgagcccc      420

atagtcacat gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca gatcagctgg      480

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac      540

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag      600

gagttcaaat gcaaggtcaa caacaaagac ctcccagcgc ccatcgagag aaccatctca      660

aaacccaaag ggtcagtaag agctccacag gtatatgtct tgcctccacc agaagaagag      720

atgactaaga aacaggtcac tctgacctgc atggtcacag acttcatgcc tgaagacatt      780

tacgtggagt ggaccaacaa cgggaaaaca gagctaaact acaagaacac tgaaccagtc      840

ctggactctg atggttctta cttcatgtac agcaagctga gagtggaaaa gaagaactgg      900

gtggaaagaa atagctactc ctgttcagtg gtccacgagg gtctgcacaa tcaccacacg      960

actaagagct tctcccggac tccgggtaaa                                       990


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 22C6 variable light chain domain (22C6-VL)

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Pro Asn 
            20                  25                  30          


Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Thr Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys His Gln Gly Asn Ser Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  partial amino acid sequence of 22C6 constant light chain domain 
       Ck

<400>  10

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
1               5                   10              


<210>  11
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 22C6 variable light chain domain (22C6-VL)

<400>  11
gaaattgttc tcacccagtc tccaaccacc atggctgcat ctcccgggga gaagatcact       60

atcacctgca gcgtcagctc aagtataagt cccaatttct tgcattggta tcagcagaag      120

ccaggattct ccccgaaact cttgattttt aggacatcca atctggcttc tggagtccca      180

actcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaattgg caccatggag      240

gctgaagacg ttgccactta ttactgtcac cagggtaata gtttaccgct cacgttcggt      300

gctgggacca agctggagct gaaa                                             324


<210>  12
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial nucleotide sequence of 22C6 constant light chain domain 
       Ck

<400>  12
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat cc                          42


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of 22C6 variable heavy chain domain (22C6-VH)

<400>  13

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Val Ser Leu Asn Cys Thr Val Thr Gly His Ser Ile Thr Asp Asp 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg Leu Val Ser Gly Ser Lys Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Thr Ser Ala Gly Asn Thr Asp Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Ile Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu His Leu Ser Ser Val Thr Ala Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Thr Asp Gly Asp Phe Tyr Phe Glu Lys Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  partial amino acid sequence of 22C6 constant heavy chain domain 
       CH1

<400>  14

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys 
            20                  25                  30  


<210>  15
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 22C6 variable heavy chain domain (22C6-VH)

<400>  15
gaggtgcagc tgcaggagtc aggacctggc ctggtgaagc cttctcagac agtgtccctc       60

aactgcactg tcactggcca ctctatcact gatgataatt actattggag ctggatccgg      120

ctggtttcag gaagcaaact ggagtggata gggtacataa cctccgctgg taacactgac      180

aacaatcctt ctctcaaaag tcgcatctcc atcacccggg acatttccaa gaaccaattc      240

ttcctgcact tgagctctgt gactgctgaa gatacagcca catattactg tgcaagagat      300

tcaactgatg gtgactttta ctttgaaaaa tggggccaag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  16
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  partial nucleotide sequence of constant 22C6 heavy chain domain 
       CH1

<400>  16
gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggaga tacaagtggc       60

tcctcggtga ctctaggatg cctggtcaag                                        90


<210>  17
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full nucleotide sequence of mAb1 light chain (mAb1-LC)

<400>  17
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gcactggtac      120

cagcagaaac cgggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggaga ctgatgatgt tgcaacctat tactgtcagc aaagtagtag ggatctgttc      300

acgttcggag gggggaccaa gctggaaata aaacgggctg atgctgcacc aactgtatcc      360

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      420

aacaacttct accccagaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      480

aatggtgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      540

agcaccctca cattgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      600

actcacaaga catcaacttc acccatcgtc aagagcttca acaggaatga gtgt            654


<210>  18
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full amino acid sequence of mAb1 light chain (mAb1-LC)

<400>  18

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      


Arg Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210>  19
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full nucleotide sequence of mAb1 heavy chain (mAb1-HC)

<400>  19
gatgtacagc ttcaggagtc aggacctggc ctggtgaagc cttctcagac agtgtccctc       60

aactgcactg tctctggcca ctctatcact gatgataatt actattggag ctggatccgg      120

ctggtttcag gaagcaaact ggagtggata gggtacataa cctccagtgg taacactgac      180

aacaatcctt ctctcaaaag tcgcatctcc gtcacccggg acatttccaa gaaccagttc      240

ttcctgcact tgagctctgt gactgctgaa gattcagcca catattactg tgcaagagat      300

tcaactgatg gtgactttta ctttgaaaaa tggggccgag gcaccactct cacagtctcc      360

tcagccaaaa caacagcccc atcggtctat ccactggccc ctgtgtgtgg agatacaagt      420

ggctcctcgg tgactctagg atgcctggtc aagggttatt tccctgagcc agtgaccttg      480

acctggaact ctggatccct gtccagtggt gtgcacacct tcccagctgt cctgcagtct      540

gacctctaca ccctcagcag ctcagtgact gtaacctcga gcacctggcc cagccagtcc      600

atcacctgca atgtggccca cccggcaagc agcaccaagg tggacaagaa aattgagccc      660

agagggccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcttgggt      720

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      780

cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc      840

tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      900

aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc      960

aaggagttca aatgcaaggt caacaacaaa gacctcccag cgcccatcga gagaaccatc     1020

tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa     1080

gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac     1140

atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca     1200

gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     1260

tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac     1320

acgactaaga gcttctcccg gactccgggt aaa                                  1353


<210>  20
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full amino acid sequence of mAb1 heavy chain (mAb1-HC)

<400>  20

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Val Ser Leu Asn Cys Thr Val Ser Gly His Ser Ile Thr Asp Asp 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg Leu Val Ser Gly Ser Lys Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Thr Ser Ser Gly Asn Thr Asp Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Ile Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu His Leu Ser Ser Val Thr Ala Glu Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Thr Asp Gly Asp Phe Tyr Phe Glu Lys Trp Gly 
            100                 105                 110         


Arg Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Ser Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
    210                 215                 220                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                245                 250                 255     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            260                 265                 270         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        275                 280                 285             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    290                 295                 300                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
305                 310                 315                 320 


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        355                 360                 365             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    370                 375                 380                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                405                 410                 415     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            420                 425                 430         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of mAb1-VL

<400>  21

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  22
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of mAb1-VL

<400>  22

Arg Ala Ser 
1           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of mAb1-VL

<400>  23

Gln Gln Ser Ser Arg Asp Leu Phe Thr 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of mAb1-VH

<400>  24

Gly His Ser Ile Thr Asp Asp Asn Tyr Tyr 
1               5                   10  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of mAb1-VH

<400>  25

Ile Thr Ser Ser Gly Asn Thr 
1               5           


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of mAb1-VH

<400>  26

Ala Arg Asp Ser Thr Asp Gly Asp Phe Tyr Phe Glu Lys 
1               5                   10              


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of 22C6-VL

<400>  27

Ser Ser Ile Ser Pro Asn Phe 
1               5           


<210>  28
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of 22C6-VL

<400>  28

Arg Thr Ser 
1           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of 22C6-VL

<400>  29

His Gln Gly Asn Ser Leu Pro Leu Thr 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR1 of 22C6-VH

<400>  30

Gly His Ser Ile Thr Asp Asp Asn Tyr Tyr 
1               5                   10  


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR2 of 22C6-VH

<400>  31

Ile Thr Ser Ala Gly Asn Thr 
1               5           


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of CDR3 of 22C6-VH

<400>  32

Ala Arg Asp Ser Thr Asp Gly Asp Phe Tyr Phe Glu Lys 
1               5                   10              


<210>  33
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of constant CH1 domain of mAb1-VH

<400>  33

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      


Asp Thr Ser Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile 
    


<210>  34
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of constant CH2 domain of mAb1-VH

<400>  34

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
            100                 105                 110 


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of constant CH3 domain of mAb1-VH

<400>  35

Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
1               5                   10                  15      


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
        35                  40                  45              


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
    50                  55                  60                  


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
65                  70                  75                  80  


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
                85                  90                  95      


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            100                 105         


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hinge region between CH1 and CH2 of 
       mAb1-VH

<400>  36

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


<210>  37
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Leu Leu Val Leu Ala Val Leu Leu Thr Val Ala Ala Ala Asp 
1               5                   10                  15      


Ser Gly Ile Ser Pro Arg Ala Val Trp Gln Phe Arg Lys Met Ile Lys 
            20                  25                  30          


Cys Val Ile Pro Gly Ser Asp Pro Phe Leu Glu Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Lys Cys Cys Gln Thr His Asp Asn Cys Tyr Asp Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Asp Ser Cys Lys Phe Leu Leu Asp Asn Pro Tyr Thr His Thr Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Gly Ser Ala Ile Thr Cys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Ala His Lys Asn Leu Asp Thr Lys Lys 
    130                 135                 140                 


Tyr Cys Gln Ser 
145             


<210>  38
<211>  148
<212>  PRT
<213>  Macaque

<400>  38

Met Lys Leu Leu Val Leu Ala Val Leu Leu Thr Val Ala Ala Ala Glu 
1               5                   10                  15      


Ser Gly Ile Ser Ser Arg Ala Val Trp Gln Phe Arg Lys Leu Ile Lys 
            20                  25                  30          


Cys Val Ile Pro Gly Ser Asp Pro Tyr Leu Glu Tyr Asn Asn Tyr Gly 
        35                  40                  45              


Cys Tyr Cys Gly Leu Gly Gly Ser Gly Thr Pro Val Asp Glu Leu Asp 
    50                  55                  60                  


Lys Cys Cys Gln Thr His Asp Asn Cys Tyr Asp Gln Ala Lys Lys Leu 
65                  70                  75                  80  


Ser Ser Cys Lys Phe Leu Leu Asp Asn Pro Tyr Thr His Thr Tyr Ser 
                85                  90                  95      


Tyr Ser Cys Ser Asn Ser Glu Ile Thr Cys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Cys Glu Ala Phe Ile Cys Asn Cys Asp Arg Asn Ala Ala Ile Cys Phe 
        115                 120                 125             


Ser Lys Ala Pro Tyr Asn Lys Glu His Lys Asn Leu Asp Ser Lys Lys 
    130                 135                 140                 


Tyr Cys Gln Ser 
145             


<210>  39
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of chimeric mAb2 light chain

<400>  39

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      


Arg Asp Leu Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  40
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of chimeric mAb2 heavy chain

<400>  40

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Val Ser Leu Asn Cys Thr Val Ser Gly His Ser Ile Thr Asp Asp 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg Leu Val Ser Gly Ser Lys Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Thr Ser Ser Gly Asn Thr Asp Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Val Thr Arg Asp Ile Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu His Leu Ser Ser Val Thr Ala Glu Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Thr Asp Gly Asp Phe Tyr Phe Glu Lys Trp Gly 
            100                 105                 110         


Arg Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of chimeric mAb2: human light chain constant 
       region

<400>  41

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  42
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of chimeric mAb2: human heavy chain constant 
       region

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


