                         SEQUENCE LISTING

<110>  SciRhom GmbH, Hospital for Special Surgery
 
<120>  Protein binders to iRhom2 epitopes

<130>  SD 45286

<160>  201   

<170>  PatentIn version 3.5

<210>  1
<211>  139
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  1

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Thr Phe Ala Met Gly Ile Gly Trp Val Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Gly Glu Lys Tyr Asn 
65                  70                  75                  80  


Asn Pro Val Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Arg Ile Ala Asn Val Asp Thr Pro Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Ser Ser Ile Tyr Tyr Ile Ile Asp Asn 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  2
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  2

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Phe 
            20                  25                  30          


Ala Met Gly Ile Gly Trp Val Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Gly Glu Lys Tyr Asn Asn Pro Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Arg Ile Ala Asn Val Asp Thr Pro Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Ser Ile Tyr Tyr Ile Ile Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  3

Thr Phe Ala Met Gly Ile Gly 
1               5           


<210>  4
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  4

His Ile Trp Trp Asp Gly Glu Lys Tyr Asn Asn Pro Val Leu Lys Ser 
1               5                   10                  15      


<210>  5
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  5

Ile Ser Ser Ile Tyr Tyr Ile Ile Asp Asn 
1               5                   10  


<210>  6
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  6

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly His Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Asn Asn Leu His Trp Tyr Gln Lys Lys Ser His Glu Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asn Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  7
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


His Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Lys Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Tyr Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  8

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  9

Tyr Val Ser Gln Ser Ile Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  10

Gln Gln Ser Tyr Asn Trp Pro Leu Thr 
1               5                   


<210>  11
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  11

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Ala Thr Ser Lys 
                85                  90                  95      


Asn Gln Ala Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Ser Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asn Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  12
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  12

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Ser Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Ala Thr Ser Lys Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asn Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  13

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  14
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  14

His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  15
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  15

Ile Ser Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asn Val 
1               5                   10              


<210>  16
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  16

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Val Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Gly 
        35                  40                  45              


Ser Ser Val Ser Cys Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Val Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Thr Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Ser Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  17
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  17

Gln Val Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Gly Ser Ser Val Ser Cys Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Val Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Thr Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Ser Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  18
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  18

Ser Ala Gly Ser Ser Val Ser Cys Met Tyr 
1               5                   10  


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  19

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  20

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  139
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  21

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Ala Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn His Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Thr Thr Tyr Tyr Tyr Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  22
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  22

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Ala Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn His Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Thr Thr Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  23

Thr Phe Ala Leu Gly Val Gly 
1               5           


<210>  24
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  24

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  25
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  25

Ile Thr Thr Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10  


<210>  26
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  26

Met Val Phe Thr Pro Gln Ile Leu Gly Leu Met Leu Phe Trp Ile Ser 
1               5                   10                  15      


Ala Ser Arg Gly Asp Ile Val Leu Ser Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Asp Ser Val Ser Leu Phe Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Asn His Leu His Trp Tyr Gln Gln Glu Ser His Ala Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Tyr 
            100                 105                 110         


Asn Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  27
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  27

Asp Ile Val Leu Ser Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Phe Cys Arg Ala Ser Gln Ser Ile Gly Asn His 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Glu Ser His Ala Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Tyr Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  28
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  28

Arg Ala Ser Gln Ser Ile Gly Asn His Leu His 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  29

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  30

Gln Gln Ser Tyr Asn Trp Pro Leu Thr 
1               5                   


<210>  31
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  31

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Ala Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Ser Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asn Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  32
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  32

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Ser Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Ala Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asn Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  33
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  33

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  34
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  34

His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  35
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  35

Ile Ser Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asn Val 
1               5                   10              


<210>  36
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  36

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Val Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Gly 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Val Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Thr Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  37
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  37

Gln Val Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Gly Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Val Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Thr Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  38
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  38

Ser Ala Gly Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  39
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  39

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  40

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  41
<211>  141
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  41

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Ser Leu Gly Val Gly Trp Ile Arg Gln Ser Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Ala Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ala Tyr Tyr Ser Lys Ser Tyr Tyr Ala Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210>  42
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  42

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Ser Leu Gly Val Gly Trp Ile Arg Gln Ser Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Ala Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Tyr Tyr Ser Lys Ser Tyr Tyr Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  43
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  43

Thr Phe Ser Leu Gly Val Gly 
1               5           


<210>  44
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  44

His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  45
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  45

Ala Tyr Tyr Ser Lys Ser Tyr Tyr Ala Leu Asp Tyr 
1               5                   10          


<210>  46
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  46

Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu 
        35                  40                  45              


Ile Ser Gly Tyr Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Ala Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala 
            100                 105                 110         


Asn Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  47
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Gly Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Ala Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln Tyr Ala Asn Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  48
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  48

Arg Ala Ser Gln Glu Ile Ser Gly Tyr Leu Ser 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  49

Ala Ala Ser Thr Leu Asp Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  50

Leu Gln Tyr Ala Asn Phe Pro Phe Thr 
1               5                   


<210>  51
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  51

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Arg Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Arg Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gln Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  52
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  52

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Arg Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Arg Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gln Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  53
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  53

Thr Phe Gly Arg Gly Val Gly 
1               5           


<210>  54
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  54

His Ile Trp Trp Asp Asp Glu Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  55
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  55

Ile Gln Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  56
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  56

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Leu Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Gly Ala Thr 
        35                  40                  45              


Ser Arg Ile Ser Tyr Met Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Val Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  57
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  57

Leu Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Gly Ala Thr Ser Arg Ile Ser Tyr Met 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Val Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  58
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  58

Gly Ala Thr Ser Arg Ile Ser Tyr Met Phe 
1               5                   10  


<210>  59
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  59

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  60

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  61
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  61

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Ala Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Ser Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Lys 
                85                  90                  95      


Asn Gln Ala Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  62
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  62

Gln Val Ala Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Ser Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Lys Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  63
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  63

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  64
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  64

Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  65
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  65

Ile Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  66
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  66

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Arg Val Thr Met Thr Cys Ser Ala Asn 
        35                  40                  45              


Ser Arg Ile Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Asn Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  67
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  67

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Asn Ser Arg Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Asn Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  68
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  68

Ser Ala Asn Ser Arg Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  69
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  69

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  70

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  71
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  71

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Glu Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Ile Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Glu Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ser Arg Ile Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  72
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  72

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Glu Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ile 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Glu Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ser Arg Ile Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  73
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  73

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  74
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  74

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  75
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  75

Ile Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  76
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  76

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Val Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Val 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Thr Ala Ser 
        35                  40                  45              


Ser Ser Val Tyr Tyr Met Tyr Trp Tyr Gln Gln Thr Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  77
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  77

Gln Ile Val Leu Thr Gln Ser Pro Ala Val Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Tyr Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Thr Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  78
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  78

Thr Ala Ser Ser Ser Val Tyr Tyr Met Tyr 
1               5                   10  


<210>  79
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  79

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  80

Gln Gln Trp Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  81
<211>  143
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  81

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Asn Tyr Tyr 
65                  70                  75                  80  


Asn Gln Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Thr Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Asn Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Arg Ser Tyr Asp Tyr Asp Val Arg Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140             


<210>  82
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  82

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Gln Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Thr Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Asn Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Ser Tyr Asp Tyr Asp Val Arg Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  83
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  83

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  84
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  84

His Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Gln Ala Leu Lys Ser 
1               5                   10                  15      


<210>  85
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  85

Ile Arg Ser Tyr Asp Tyr Asp Val Arg Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  86
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  86

Met Arg Thr Pro Ala Gln Phe Leu Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Arg Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Tyr Glu Asp Leu Gly Ile Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
        115                 120                 125         


<210>  87
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  87

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Arg 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Gln Gln Tyr Tyr Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105         


<210>  88
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  88

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  89
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  89

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  90
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  90

Gln Gln Tyr Tyr Glu Phe Pro Leu Thr 
1               5                   


<210>  91
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  91

Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Phe Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Ile Leu Asn Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Asp Leu Lys Arg Ala Met Asp His Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     


<210>  92
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  92

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Asn Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ile Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Leu Lys Arg Ala Met Asp His Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  93
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  93

Asn Tyr Leu Ile Glu 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  94

Val Ile Asn Pro Gly Ser Gly Phe Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  95

Asp Leu Lys Arg Ala Met Asp His 
1               5               


<210>  96
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  96

Met Leu Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Ala Gly Gly 
1               5                   10                  15      


Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly 
        35                  40                  45              


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu 
    50                  55                  60                  


Leu Ile His Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu 
                85                  90                  95      


Gln Ala Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Ile Tyr Ser Ser 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125 


<210>  97
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


His Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Ile Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  98
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  98

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  99
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  99

Ala Ala Thr Ser Leu Ala Asp 
1               5           


<210>  100
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  100

Gln Gln Ile Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  101
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  101

Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Phe Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Val Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Leu Tyr Arg Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     


<210>  102
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  102

Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Phe Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  103
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  103

Asn Tyr Leu Ile Glu 
1               5   


<210>  104
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  104

Val Ile Asn Pro Gly Ser Gly Phe Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  105

Gly Leu Tyr Arg Ala Met Asp Tyr 
1               5               


<210>  106
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  106

Met Leu Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Ala Gly Gly 
1               5                   10                  15      


Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Ala 
        35                  40                  45              


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu 
    50                  55                  60                  


Leu Ile Tyr Gly Ala Thr Thr Leu Ala Asp Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Gly Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu 
                85                  90                  95      


Gln Ala Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125 


<210>  107
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Ala Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  108
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  108

Leu Ala Ser Gln Thr Ile Ala Thr Trp Leu Ala 
1               5                   10      


<210>  109
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  109

Gly Ala Thr Thr Leu Ala Asp 
1               5           


<210>  110
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  110

Gln Gln Leu Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  111
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  111

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Gln Ser Arg Leu Thr Val Ser Lys Asp Thr Ala Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Arg Val Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Ala Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  112
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  112

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Gln Ser Arg Leu Thr Val Ser Lys Asp Thr Ala Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Ala Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  113
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  113

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  114
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  114

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Gln Ser 
1               5                   10                  15      


<210>  115
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  115

Val Gly Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Ala Val 
1               5                   10              


<210>  116
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  116

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  117
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  117

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  118
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  118

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  119
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  119

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  120
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  120

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  121
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  121

Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Ser Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Phe Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Leu Tyr Arg Ala Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     


<210>  122
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  122

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Phe Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  123
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  123

Asn Tyr Leu Ile Glu 
1               5   


<210>  124
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  124

Val Ile Asn Pro Gly Ser Gly Phe Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  125
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  125

Gly Leu Tyr Arg Ala Met Asp Tyr 
1               5               


<210>  126
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  126

Met Leu Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Ala Gly Gly 
1               5                   10                  15      


Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser 
            20                  25                  30          


Leu Gly Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly 
        35                  40                  45              


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu 
    50                  55                  60                  


Leu Ile Tyr Ala Ala Ala Ser Leu Ala Asp Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Gly Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu 
                85                  90                  95      


Gln Ala Glu Asp Phe Val Asn Tyr Tyr Cys Gln Gln Ile Tyr Ser Thr 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125 


<210>  127
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ala Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Asn Tyr Tyr Cys Gln Gln Ile Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  128
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  128

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  129
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  129

Ala Ala Ala Ser Leu Ala Asp 
1               5           


<210>  130
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  130

Gln Gln Ile Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  131
<211>  135
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  131

Met Glu Trp Pro Leu Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val Gln Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Gly Lys Phe Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Asp Leu Val Phe Val Tyr Trp Gly Leu Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala 
    130                 135 


<210>  132
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  132

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Leu Val Phe Val Tyr Trp Gly Leu Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  133
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  133

Asn Tyr Trp Met Asn 
1               5   


<210>  134
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  134

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Lys Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  135
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  135

Gly Asp Leu Val Phe Val Tyr 
1               5           


<210>  136
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  136

Met Arg Phe Gln Val Gln Val Leu Gly Leu Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Gln Cys Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Asn 
        35                  40                  45              


Ile Arg Lys Tyr Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Gly Ser Thr Ser Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn 
            100                 105                 110         


Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  137
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  137

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Asn Ile Arg Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Ser Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  138
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  138

Arg Ala Ser Lys Asn Ile Arg Lys Tyr Leu Ala 
1               5                   10      


<210>  139
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  139

Ser Gly Ser Thr Ser Gln Ser 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  140

Gln Gln His Asn Glu Tyr Pro Tyr Thr 
1               5                   


<210>  141
<211>  136
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  141

Met Glu Trp Ser Arg Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe 
        35                  40                  45              


Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Phe Asn Pro Glu Ser Gly Tyr Ile Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Leu Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Thr Ser Arg Arg Gly Phe Asp Tyr Trp Gly His 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135     


<210>  142
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  142

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Phe Asn Pro Glu Ser Gly Tyr Ile Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Ser Arg Arg Gly Phe Asp Tyr Trp Gly His Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  143
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  143

Asn Tyr Leu Ile Glu 
1               5   


<210>  144
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  144

Val Phe Asn Pro Glu Ser Gly Tyr Ile Asn Tyr Asn Glu Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  145
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  145

Thr Ser Arg Arg Gly Phe Asp Tyr 
1               5               


<210>  146
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  146

Met Asn Met Leu Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Phe Ala 
1               5                   10                  15      


Gly Gly Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr 
        35                  40                  45              


Ile Gly Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser 
                85                  90                  95      


Ser Leu Gln Ala Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr 
            100                 105                 110         


Ser Thr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  147
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  147

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  148
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  148

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala 
1               5                   10      


<210>  149
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  149

Ala Ala Thr Ser Leu Ala Asp 
1               5           


<210>  150
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  150

Gln Gln Leu Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  151
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  151

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Cys Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Ser 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Ser Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Phe Cys Ala Arg Ile Leu Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  152
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  152

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Cys Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Ser Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Ser Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ile Leu Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  153
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  153

Thr Phe Gly Leu Gly Val Gly 
1               5           


<210>  154
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  154

His Ile Trp Trp Asp Asp Asp Lys Tyr Ser Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  155
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  155

Ile Leu Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  156
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  156

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Ile Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Ser Leu Thr Val 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  157
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  157

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Leu Thr Val Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  158
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  158

Ser Ala Ser Ser Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  159
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  159

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  160
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  160

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  161
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  161

Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Thr Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Ser Val Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Ala Ala Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  162
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  162

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Thr Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Ser Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ala Ala Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  163
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  163

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  164
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  164

Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Ser Val Leu Lys Ser 
1               5                   10                  15      


<210>  165
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  165

Ile Ala Ala Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  166
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  166

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Val Leu Ile Tyr Asp Thr Ser Asn Leu Ser Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  167
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  167

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Val Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ser Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  168
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  168

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  169
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  169

Asp Thr Ser Asn Leu Ser Ser 
1               5           


<210>  170
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  170

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  171
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  171

Met Gly Arg Leu Thr Ser Ser Leu Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Ile Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ser Ala 
            100                 105                 110         


Thr Phe Tyr Cys Ala Arg Ile Glu Asn Tyr Gly Ser Asn Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140         


<210>  172
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  172

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ile 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ser Ala Thr Phe Tyr 
                85                  90                  95      


Cys Ala Arg Ile Glu Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  173
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  173

Thr Phe Gly Met Gly Val Gly 
1               5           


<210>  174
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  174

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  175
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  175

Ile Glu Asn Tyr Gly Ser Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  176
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  176

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Arg Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Val Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210>  177
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  177

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Val Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  178
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  178

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  179
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  179

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  180
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody sequence of fragment

<400>  180

Gln Gln Trp Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  181
<211>  856
<212>  PRT
<213>  Homo sapiens iRhom2 wildtype

<400>  181

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His 
    850                 855     


<210>  182
<211>  855
<212>  PRT
<213>  Homo sapiens iRhom1 wildtype

<400>  182

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His 
    50                  55                  60                  


Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys 
    210                 215                 220                 


Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu 
            260                 265                 270         


Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro 
                325                 330                 335     


Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg 
            340                 345                 350         


Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys 
        355                 360                 365             


Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr 
    370                 375                 380                 


Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp 
385                 390                 395                 400 


Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu 
                405                 410                 415     


Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe 
            420                 425                 430         


Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr 
        435                 440                 445             


Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser 
    450                 455                 460                 


Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg 
465                 470                 475                 480 


Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu 
                485                 490                 495     


Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln 
            500                 505                 510         


Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp 
        515                 520                 525             


Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe 
    530                 535                 540                 


Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser 
545                 550                 555                 560 


Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys 
                565                 570                 575     


Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys 
            580                 585                 590         


Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu 
        595                 600                 605             


Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu 
    610                 615                 620                 


Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly 
625                 630                 635                 640 


Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu 
                645                 650                 655     


Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser 
            660                 665                 670         


Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly 
        675                 680                 685             


Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn 
    690                 695                 700                 


Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln 
                725                 730                 735     


Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu 
            740                 745                 750         


Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp 
        755                 760                 765             


Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe 
    770                 775                 780                 


Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys 
785                 790                 795                 800 


Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala 
                805                 810                 815     


Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys 
            820                 825                 830         


Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr 
        835                 840                 845             


Glu Leu Asp Ala Gln Leu His 
    850                 855 


<210>  183
<211>  827
<212>  PRT
<213>  Mus musculus iRhom2 wildtype

<400>  183

Met Ala Ser Ala Asp Lys Asn Gly Ser Asn Leu Pro Ser Val Ser Gly 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Ser Gln Ala Pro Gly Glu Gln Asp Ser Met Leu Pro Glu 
        35                  40                  45              


Arg Arg Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro 
    50                  55                  60                  


Arg Gly Arg Trp Gln Glu Gly Ala Glu Lys Arg Pro Gly Phe Arg Arg 
65                  70                  75                  80  


Gln Ala Ser Leu Ser Gln Ser Ile Arg Lys Ser Thr Ala Gln Trp Phe 
                85                  90                  95      


Gly Val Ser Gly Asp Trp Glu Gly Lys Arg Gln Asn Trp His Arg Arg 
            100                 105                 110         


Ser Leu His His Cys Ser Val His Tyr Gly Arg Leu Lys Ala Ser Cys 
        115                 120                 125             


Gln Arg Glu Leu Glu Leu Pro Ser Gln Glu Val Pro Ser Phe Gln Gly 
    130                 135                 140                 


Thr Glu Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu 
145                 150                 155                 160 


Ala Arg Gly Arg Ala Phe Arg His Pro Asp Glu Val Asp Arg Pro His 
                165                 170                 175     


Ala Ala His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe 
            180                 185                 190         


Thr Ser Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Ile 
        195                 200                 205             


Ser Val Ala His Met Ser Phe Gln Ala Ala Ala Ala Leu Leu Lys Gly 
    210                 215                 220                 


Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg His Val Lys Arg 
225                 230                 235                 240 


Ser Phe Ala Tyr Pro Ser Phe Leu Glu Glu Asp Ala Val Asp Gly Ala 
                245                 250                 255     


Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met 
            260                 265                 270         


Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg 
        275                 280                 285             


Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val His Ile 
    290                 295                 300                 


Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly Pro Gly Thr Gln 
305                 310                 315                 320 


Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg 
                325                 330                 335     


Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg 
            340                 345                 350         


Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser 
        355                 360                 365             


Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His 
    370                 375                 380                 


Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val 
385                 390                 395                 400 


Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Lys Asn Arg Gly 
                405                 410                 415     


Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Ile Gly 
            420                 425                 430         


Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys 
        435                 440                 445             


Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg Arg Glu Arg Asp 
    450                 455                 460                 


Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp Arg Ser Gly Cys 
465                 470                 475                 480 


Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val 
                485                 490                 495     


Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser Asp Leu Ser Gln 
            500                 505                 510         


Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro Arg Thr Cys Glu 
        515                 520                 525             


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
    530                 535                 540                 


Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His Thr Gly Leu Leu 
545                 550                 555                 560 


His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
                565                 570                 575     


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
            580                 585                 590         


Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
        595                 600                 605             


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
    610                 615                 620                 


Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala Gly Ile Val His 
625                 630                 635                 640 


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
                645                 650                 655     


Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe Ile Leu Ser Gly 
            660                 665                 670         


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
        675                 680                 685             


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
    690                 695                 700                 


Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro Trp Lys Ala Phe 
705                 710                 715                 720 


Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
                725                 730                 735     


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Met 
            740                 745                 750         


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
        755                 760                 765             


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Val Phe Ala 
    770                 775                 780                 


Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
785                 790                 795                 800 


Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
                805                 810                 815     


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
            820                 825         


<210>  184
<211>  856
<212>  PRT
<213>  Homo sapiens iRhom2 I186T

<400>  184

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Thr Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His 
    850                 855     


<210>  185
<211>  614
<212>  PRT
<213>  Homo sapiens iRhom2, deletion of first 242 AA

<400>  185

Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser Val Leu 
1               5                   10                  15      


Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe Ala Phe 
            20                  25                  30          


Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr Phe Asp 
        35                  40                  45              


Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp Asp Val 
    50                  55                  60                  


Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile Pro His 
65                  70                  75                  80  


Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu Lys Glu 
                85                  90                  95      


Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg Ile Ala 
            100                 105                 110         


Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His Tyr Gly 
        115                 120                 125             


Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg Ser Ile 
    130                 135                 140                 


Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His Arg Pro 
145                 150                 155                 160 


Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr Leu Leu 
                165                 170                 175     


Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln His Val 
            180                 185                 190         


Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser Val Lys 
        195                 200                 205             


Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile Asp Leu 
    210                 215                 220                 


Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp Gly Gln 
225                 230                 235                 240 


Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp Ser Gly 
                245                 250                 255     


Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln Arg Lys 
            260                 265                 270         


Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp Asp Thr 
        275                 280                 285             


Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr Ser Gly 
    290                 295                 300                 


Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala Ser Ser 
305                 310                 315                 320 


Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile Cys Thr 
                325                 330                 335     


Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp Cys Glu 
            340                 345                 350         


Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys Glu Ile 
        355                 360                 365             


Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His Glu Glu 
    370                 375                 380                 


Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys Gly Leu 
385                 390                 395                 400 


Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu Trp 
                405                 410                 415     


Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val Ser Val 
            420                 425                 430         


Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala Gly Trp 
        435                 440                 445             


His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly Asn Leu 
    450                 455                 460                 


Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala Gly 
465                 470                 475                 480 


Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe Gln Ser 
                485                 490                 495     


Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu Ser Ala 
            500                 505                 510         


Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile Asp Asn 
        515                 520                 525             


Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala Phe Ala 
    530                 535                 540                 


Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg Lys Arg 
545                 550                 555                 560 


Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe Ala Ala 
                565                 570                 575     


Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp Ile Glu 
            580                 585                 590         


His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys Tyr Glu 
        595                 600                 605             


Leu Asp Gln Val Leu His 
    610                 


<210>  186
<211>  827
<212>  PRT
<213>  Mus musculus iRhom2, full length, I156T

<400>  186

Met Ala Ser Ala Asp Lys Asn Gly Ser Asn Leu Pro Ser Val Ser Gly 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Ser Gln Ala Pro Gly Glu Gln Asp Ser Met Leu Pro Glu 
        35                  40                  45              


Arg Arg Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro 
    50                  55                  60                  


Arg Gly Arg Trp Gln Glu Gly Ala Glu Lys Arg Pro Gly Phe Arg Arg 
65                  70                  75                  80  


Gln Ala Ser Leu Ser Gln Ser Ile Arg Lys Ser Thr Ala Gln Trp Phe 
                85                  90                  95      


Gly Val Ser Gly Asp Trp Glu Gly Lys Arg Gln Asn Trp His Arg Arg 
            100                 105                 110         


Ser Leu His His Cys Ser Val His Tyr Gly Arg Leu Lys Ala Ser Cys 
        115                 120                 125             


Gln Arg Glu Leu Glu Leu Pro Ser Gln Glu Val Pro Ser Phe Gln Gly 
    130                 135                 140                 


Thr Glu Ser Pro Lys Pro Cys Lys Met Pro Lys Thr Val Asp Pro Leu 
145                 150                 155                 160 


Ala Arg Gly Arg Ala Phe Arg His Pro Asp Glu Val Asp Arg Pro His 
                165                 170                 175     


Ala Ala His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe 
            180                 185                 190         


Thr Ser Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Ile 
        195                 200                 205             


Ser Val Ala His Met Ser Phe Gln Ala Ala Ala Ala Leu Leu Lys Gly 
    210                 215                 220                 


Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg His Val Lys Arg 
225                 230                 235                 240 


Ser Phe Ala Tyr Pro Ser Phe Leu Glu Glu Asp Ala Val Asp Gly Ala 
                245                 250                 255     


Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met 
            260                 265                 270         


Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg 
        275                 280                 285             


Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val His Ile 
    290                 295                 300                 


Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly Pro Gly Thr Gln 
305                 310                 315                 320 


Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg 
                325                 330                 335     


Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg 
            340                 345                 350         


Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser 
        355                 360                 365             


Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His 
    370                 375                 380                 


Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val 
385                 390                 395                 400 


Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Lys Asn Arg Gly 
                405                 410                 415     


Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Ile Gly 
            420                 425                 430         


Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys 
        435                 440                 445             


Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg Arg Glu Arg Asp 
    450                 455                 460                 


Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp Arg Ser Gly Cys 
465                 470                 475                 480 


Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val 
                485                 490                 495     


Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser Asp Leu Ser Gln 
            500                 505                 510         


Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro Arg Thr Cys Glu 
        515                 520                 525             


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
    530                 535                 540                 


Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His Thr Gly Leu Leu 
545                 550                 555                 560 


His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
                565                 570                 575     


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
            580                 585                 590         


Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
        595                 600                 605             


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
    610                 615                 620                 


Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala Gly Ile Val His 
625                 630                 635                 640 


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
                645                 650                 655     


Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe Ile Leu Ser Gly 
            660                 665                 670         


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
        675                 680                 685             


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
    690                 695                 700                 


Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro Trp Lys Ala Phe 
705                 710                 715                 720 


Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
                725                 730                 735     


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Met 
            740                 745                 750         


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
        755                 760                 765             


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Val Phe Ala 
    770                 775                 780                 


Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
785                 790                 795                 800 


Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
                805                 810                 815     


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
            820                 825         


<210>  187
<211>  615
<212>  PRT
<213>  Mus musculus iRhom2, deletion of first 212 AA

<400>  187

Met Ser Phe Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser Val Leu 
1               5                   10                  15      


Asp Ala Thr Gly Gln Arg Cys Arg His Val Lys Arg Ser Phe Ala Tyr 
            20                  25                  30          


Pro Ser Phe Leu Glu Glu Asp Ala Val Asp Gly Ala Asp Thr Phe Asp 
        35                  40                  45              


Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp Asp Val 
    50                  55                  60                  


Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Val Pro His 
65                  70                  75                  80  


Ser Ala Ser Pro Val Ser Pro Asp Gly Val His Ile Pro Leu Lys Glu 
                85                  90                  95      


Tyr Ser Gly Gly Arg Ala Leu Gly Pro Gly Thr Gln Arg Gly Lys Arg 
            100                 105                 110         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        115                 120                 125             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    130                 135                 140                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
145                 150                 155                 160 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Ile Ile Ile Thr 
                165                 170                 175     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            180                 185                 190         


His Val Thr Thr Gln Leu Val Leu Lys Asn Arg Gly Val Tyr Glu Ser 
        195                 200                 205             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser Ser Ile 
    210                 215                 220                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
225                 230                 235                 240 


Gln Gln Ile Glu Gln Leu Val Arg Arg Glu Arg Asp Ile Glu Arg Thr 
                245                 250                 255     


Ser Gly Cys Cys Val Gln Asn Asp Arg Ser Gly Cys Ile Gln Thr Leu 
            260                 265                 270         


Lys Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asn 
        275                 280                 285             


Asp Thr Gly Pro Ser Asp Lys Ser Asp Leu Ser Gln Lys Gln Pro Ser 
    290                 295                 300                 


Ala Val Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala Ser 
305                 310                 315                 320 


Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile Cys 
                325                 330                 335     


Thr Glu Gln Ala Gln Ser Asn His Thr Gly Leu Leu His Ile Asp Cys 
            340                 345                 350         


Lys Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys Glu 
        355                 360                 365             


Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His Glu 
    370                 375                 380                 


Asp Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys Gly 
385                 390                 395                 400 


Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Ile 
                405                 410                 415     


Trp Leu Ser Leu Phe Leu His Ala Gly Ile Val His Cys Leu Val Ser 
            420                 425                 430         


Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala Gly 
        435                 440                 445             


Trp His Arg Ile Ser Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly Asn 
    450                 455                 460                 


Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala 
465                 470                 475                 480 


Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe Gln 
                485                 490                 495     


Ser Trp Gln Leu Leu Glu Arg Pro Trp Lys Ala Phe Phe Asn Leu Ser 
            500                 505                 510         


Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile Asp 
        515                 520                 525             


Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Met Leu Leu Ala Phe 
    530                 535                 540                 


Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg Lys 
545                 550                 555                 560 


Arg Ala Leu Ile Leu Val Ser Leu Leu Val Phe Ala Gly Leu Phe Ala 
                565                 570                 575     


Ser Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp Ile 
            580                 585                 590         


Glu Tyr Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys Tyr 
        595                 600                 605             


Glu Leu Asp Gln Val Leu His 
    610                 615 


<210>  188
<211>  559
<212>  PRT
<213>  Mus musculus iRhom2, deletion of first 268 AA

<400>  188

Met Ser Ser Met Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala 
1               5                   10                  15      


Ser Tyr Phe Arg Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp 
            20                  25                  30          


Gly Val His Ile Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly 
        35                  40                  45              


Pro Gly Thr Gln Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe 
    50                  55                  60                  


Ala Phe Asp Arg Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn 
65                  70                  75                  80  


Trp Leu Asn Arg Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg 
                85                  90                  95      


Gln Leu Glu Ser Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu 
            100                 105                 110         


Thr Phe Val His Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly 
        115                 120                 125             


Ile Ala Pro Val Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu 
    130                 135                 140                 


Lys Asn Arg Gly Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn 
145                 150                 155                 160 


Phe Trp Ile Gly Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys 
                165                 170                 175     


Phe Ser Pro Cys Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg 
            180                 185                 190         


Arg Glu Arg Asp Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp 
        195                 200                 205             


Arg Ser Gly Cys Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu 
    210                 215                 220                 


Ala Thr Phe Val Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser 
225                 230                 235                 240 


Asp Leu Ser Gln Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro 
                245                 250                 255     


Arg Thr Cys Glu Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp 
            260                 265                 270         


Asp Ile Thr Lys Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His 
        275                 280                 285             


Thr Gly Leu Leu His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys 
    290                 295                 300                 


Ile Gly Thr Lys Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu 
305                 310                 315                 320 


Phe Met His Gly Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val 
                325                 330                 335     


His Cys Leu Asp Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu 
            340                 345                 350         


Val Pro Asp Gln Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala 
        355                 360                 365             


Gly Ile Val His Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu 
    370                 375                 380                 


Arg Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe 
385                 390                 395                 400 


Ile Leu Ser Gly Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro 
                405                 410                 415     


Tyr Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala 
            420                 425                 430         


Cys Leu Phe Val Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro 
        435                 440                 445             


Trp Lys Ala Phe Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile 
    450                 455                 460                 


Cys Gly Leu Leu Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe 
465                 470                 475                 480 


Leu Ser Gly Met Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe 
                485                 490                 495     


Gly Thr Ser Asp Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu 
            500                 505                 510         


Leu Val Phe Ala Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile 
        515                 520                 525             


Tyr Pro Ile Asn Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe 
    530                 535                 540                 


Thr Ser Arg Phe Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
545                 550                 555                 


<210>  189
<211>  888
<212>  PRT
<213>  Homo sapiens iRhom1, full length, wild type, triple T7-Tag

<400>  189

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His 
    50                  55                  60                  


Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys 
    210                 215                 220                 


Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu 
            260                 265                 270         


Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro 
                325                 330                 335     


Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg 
            340                 345                 350         


Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys 
        355                 360                 365             


Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr 
    370                 375                 380                 


Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp 
385                 390                 395                 400 


Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu 
                405                 410                 415     


Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe 
            420                 425                 430         


Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr 
        435                 440                 445             


Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser 
    450                 455                 460                 


Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg 
465                 470                 475                 480 


Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu 
                485                 490                 495     


Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln 
            500                 505                 510         


Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp 
        515                 520                 525             


Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe 
    530                 535                 540                 


Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser 
545                 550                 555                 560 


Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys 
                565                 570                 575     


Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys 
            580                 585                 590         


Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu 
        595                 600                 605             


Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu 
    610                 615                 620                 


Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly 
625                 630                 635                 640 


Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu 
                645                 650                 655     


Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser 
            660                 665                 670         


Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly 
        675                 680                 685             


Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn 
    690                 695                 700                 


Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln 
                725                 730                 735     


Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu 
            740                 745                 750         


Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp 
        755                 760                 765             


Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe 
    770                 775                 780                 


Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys 
785                 790                 795                 800 


Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala 
                805                 810                 815     


Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys 
            820                 825                 830         


Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr 
        835                 840                 845             


Glu Leu Asp Ala Gln Leu His Met Ala Ser Met Thr Gly Gly Gln Gln 
    850                 855                 860                 


Met Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Met Ala Ser 
865                 870                 875                 880 


Met Thr Gly Gly Gln Gln Met Gly 
                885             


<210>  190
<211>  889
<212>  PRT
<213>  Homo sapiens iRhom2, full length, wild type, triple T7-Tag

<400>  190

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His Met Ala Ser Met Thr Gly Gly Gln 
    850                 855                 860                 


Gln Met Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Met Ala 
865                 870                 875                 880 


Ser Met Thr Gly Gly Gln Gln Met Gly 
                885                 


<210>  191
<211>  647
<212>  PRT
<213>  Homo sapiens iRhom2, deletion of first 242 AA, triple T7-Tag

<400>  191

Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser Val Leu 
1               5                   10                  15      


Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe Ala Phe 
            20                  25                  30          


Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr Phe Asp 
        35                  40                  45              


Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp Asp Val 
    50                  55                  60                  


Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile Pro His 
65                  70                  75                  80  


Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu Lys Glu 
                85                  90                  95      


Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg Ile Ala 
            100                 105                 110         


Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His Tyr Gly 
        115                 120                 125             


Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg Ser Ile 
    130                 135                 140                 


Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His Arg Pro 
145                 150                 155                 160 


Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr Leu Leu 
                165                 170                 175     


Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln His Val 
            180                 185                 190         


Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser Val Lys 
        195                 200                 205             


Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile Asp Leu 
    210                 215                 220                 


Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp Gly Gln 
225                 230                 235                 240 


Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp Ser Gly 
                245                 250                 255     


Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln Arg Lys 
            260                 265                 270         


Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp Asp Thr 
        275                 280                 285             


Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr Ser Gly 
    290                 295                 300                 


Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala Ser Ser 
305                 310                 315                 320 


Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile Cys Thr 
                325                 330                 335     


Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp Cys Glu 
            340                 345                 350         


Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys Glu Ile 
        355                 360                 365             


Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His Glu Glu 
    370                 375                 380                 


Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys Gly Leu 
385                 390                 395                 400 


Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu Trp 
                405                 410                 415     


Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val Ser Val 
            420                 425                 430         


Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala Gly Trp 
        435                 440                 445             


His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly Asn Leu 
    450                 455                 460                 


Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala Gly 
465                 470                 475                 480 


Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe Gln Ser 
                485                 490                 495     


Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu Ser Ala 
            500                 505                 510         


Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile Asp Asn 
        515                 520                 525             


Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala Phe Ala 
    530                 535                 540                 


Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg Lys Arg 
545                 550                 555                 560 


Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe Ala Ala 
                565                 570                 575     


Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp Ile Glu 
            580                 585                 590         


His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys Tyr Glu 
        595                 600                 605             


Leu Asp Gln Val Leu His Met Ala Ser Met Thr Gly Gly Gln Gln Met 
    610                 615                 620                 


Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Met Ala Ser Met 
625                 630                 635                 640 


Thr Gly Gly Gln Gln Met Gly 
                645         


<210>  192
<211>  889
<212>  PRT
<213>  Mus musculus iRhom1, full length, wild type, triple T7-Tag

<400>  192

Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys 
1               5                   10                  15      


Pro Pro Trp Leu Lys Leu Asp Ile Pro Ala Ala Val Pro Pro Ala Ala 
            20                  25                  30          


Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg 
        35                  40                  45              


Ser Val Ser Met Pro Ala Glu Thr Ala Arg Val Pro Ser Pro His His 
    50                  55                  60                  


Glu Pro Arg Arg Leu Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr 
65                  70                  75                  80  


Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp 
                85                  90                  95      


Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg 
            100                 105                 110         


Tyr Gly Lys Leu Lys Pro Gln Val Ile Arg Glu Leu Asp Leu Pro Ser 
        115                 120                 125             


Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr 
    130                 135                 140                 


Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala 
145                 150                 155                 160 


Arg Gly Arg Ala Phe Arg Met Ala Asp Asp Thr Ala Asp Gly Leu Ser 
                165                 170                 175     


Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe 
            180                 185                 190         


Ser Ser Ser Arg Ser Gly Phe Asn Arg Leu Pro Arg Arg Arg Lys Arg 
        195                 200                 205             


Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Val Lys 
    210                 215                 220                 


Gly Arg Ser Ile Arg Asp Gly Thr Leu Arg Arg Gly Gln Arg Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Met Val Asp Phe Pro Asp 
                245                 250                 255     


Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Val Leu His Glu Glu 
            260                 265                 270         


Met Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala 
        275                 280                 285             


Leu Lys Asp Trp Glu Lys Ala Pro Asp Gln Ala Asp Leu Thr Gly Gly 
    290                 295                 300                 


Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu 
305                 310                 315                 320 


Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Gly Pro Leu Ala Pro Gln 
                325                 330                 335     


Pro Lys Val Arg Leu Arg Gln Glu Val Val Ser Ala Ala Gly Pro Arg 
            340                 345                 350         


Arg Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu 
        355                 360                 365             


Lys Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr 
    370                 375                 380                 


Tyr Arg Lys Arg Ile Asp Ser Tyr Val Lys Arg Gln Ile Glu Asp Met 
385                 390                 395                 400 


Asp Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser 
                405                 410                 415     


Leu Val Thr Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly 
            420                 425                 430         


Phe Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Lys Arg Gly Val 
        435                 440                 445             


Tyr Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro 
    450                 455                 460                 


Ser Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met 
465                 470                 475                 480 


Arg Gln Asp Pro Gln Val His Ser Phe Ile Leu Ala Ala Arg Glu Arg 
                485                 490                 495     


Glu Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val 
            500                 505                 510         


Gln Thr Ser Lys Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys 
        515                 520                 525             


Trp Pro Val His Pro Ser Ala Pro Asp Leu Ala Gly Asn Lys Arg Gln 
    530                 535                 540                 


Phe Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser 
545                 550                 555                 560 


Ser Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Lys Ser Ser Ala Gly Asn His Thr Asn His Pro His Met Asp 
            580                 585                 590         


Cys Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys 
        595                 600                 605             


Glu Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val 
            660                 665                 670         


Ser Val Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu 
            740                 745                 750         


Leu Ala Val Val Leu Phe Leu Phe Ala Phe Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Phe Ala His Ile Ser Gly Phe Val Ser Gly Leu Phe Leu Ser 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg 
785                 790                 795                 800 


Lys Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu 
                805                 810                 815     


Ala Gly Leu Val Val Leu Phe Tyr Phe Tyr Pro Val Arg Cys Glu Trp 
            820                 825                 830         


Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Ala Gln Leu His Met Ala Ser Met Thr Gly Gly Gln 
    850                 855                 860                 


Gln Met Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Met Ala 
865                 870                 875                 880 


Ser Met Thr Gly Gly Gln Gln Met Gly 
                885                 


<210>  193
<211>  860
<212>  PRT
<213>  Mus musculus iRhom2, full length, wild type, triple T7-Tag

<400>  193

Met Ala Ser Ala Asp Lys Asn Gly Ser Asn Leu Pro Ser Val Ser Gly 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Ser Gln Ala Pro Gly Glu Gln Asp Ser Met Leu Pro Glu 
        35                  40                  45              


Arg Arg Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro 
    50                  55                  60                  


Arg Gly Arg Trp Gln Glu Gly Ala Glu Lys Arg Pro Gly Phe Arg Arg 
65                  70                  75                  80  


Gln Ala Ser Leu Ser Gln Ser Ile Arg Lys Ser Thr Ala Gln Trp Phe 
                85                  90                  95      


Gly Val Ser Gly Asp Trp Glu Gly Lys Arg Gln Asn Trp His Arg Arg 
            100                 105                 110         


Ser Leu His His Cys Ser Val His Tyr Gly Arg Leu Lys Ala Ser Cys 
        115                 120                 125             


Gln Arg Glu Leu Glu Leu Pro Ser Gln Glu Val Pro Ser Phe Gln Gly 
    130                 135                 140                 


Thr Glu Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu 
145                 150                 155                 160 


Ala Arg Gly Arg Ala Phe Arg His Pro Asp Glu Val Asp Arg Pro His 
                165                 170                 175     


Ala Ala His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe 
            180                 185                 190         


Thr Ser Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Ile 
        195                 200                 205             


Ser Val Ala His Met Ser Phe Gln Ala Ala Ala Ala Leu Leu Lys Gly 
    210                 215                 220                 


Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg His Val Lys Arg 
225                 230                 235                 240 


Ser Phe Ala Tyr Pro Ser Phe Leu Glu Glu Asp Ala Val Asp Gly Ala 
                245                 250                 255     


Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met 
            260                 265                 270         


Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg 
        275                 280                 285             


Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val His Ile 
    290                 295                 300                 


Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly Pro Gly Thr Gln 
305                 310                 315                 320 


Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg 
                325                 330                 335     


Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg 
            340                 345                 350         


Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser 
        355                 360                 365             


Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His 
    370                 375                 380                 


Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val 
385                 390                 395                 400 


Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Lys Asn Arg Gly 
                405                 410                 415     


Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Ile Gly 
            420                 425                 430         


Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys 
        435                 440                 445             


Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg Arg Glu Arg Asp 
    450                 455                 460                 


Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp Arg Ser Gly Cys 
465                 470                 475                 480 


Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val 
                485                 490                 495     


Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser Asp Leu Ser Gln 
            500                 505                 510         


Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro Arg Thr Cys Glu 
        515                 520                 525             


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
    530                 535                 540                 


Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His Thr Gly Leu Leu 
545                 550                 555                 560 


His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
                565                 570                 575     


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
            580                 585                 590         


Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
        595                 600                 605             


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
    610                 615                 620                 


Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala Gly Ile Val His 
625                 630                 635                 640 


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
                645                 650                 655     


Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe Ile Leu Ser Gly 
            660                 665                 670         


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
        675                 680                 685             


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
    690                 695                 700                 


Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro Trp Lys Ala Phe 
705                 710                 715                 720 


Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
                725                 730                 735     


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Met 
            740                 745                 750         


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
        755                 760                 765             


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Val Phe Ala 
    770                 775                 780                 


Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
785                 790                 795                 800 


Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
                805                 810                 815     


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His Met Ala Ser Met Thr 
            820                 825                 830         


Gly Gly Gln Gln Met Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met 
        835                 840                 845             


Gly Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
    850                 855                 860 


<210>  194
<211>  160
<212>  PRT
<213>  Homo sapiens TGFa, full length, wild type

<400>  194

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                  25                  30          


Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                  40                  45              


Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                  55                  60                  


Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                  70                  75                  80  


Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                  90                  95      


Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                 105                 110         


Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                 120                 125             


His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                 135                 140                 


Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 160 


<210>  195
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  mRhbdf2.3 fwd  primer

<400>  195
tcaatgagct ctttatgggg ca                                                22


<210>  196
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  mRhbdf2.3 rev primer

<400>  196
aaggtctcca tcccctcagg tc                                                22


<210>  197
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  mRhbdf2.3 IVT gRNA

<400>  197
aagcatgcta tcctgctcgc                                                   20


<210>  198
<211>  878
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His Asp Tyr Lys Asp His Asp Gly Asp 
    850                 855                 860                 


Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
865                 870                 875             


<210>  199
<211>  849
<212>  PRT
<213>  Mus musculus

<400>  199

Met Ala Ser Ala Asp Lys Asn Gly Ser Asn Leu Pro Ser Val Ser Gly 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Ser Gln Ala Pro Gly Glu Gln Asp Ser Met Leu Pro Glu 
        35                  40                  45              


Arg Arg Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro 
    50                  55                  60                  


Arg Gly Arg Trp Gln Glu Gly Ala Glu Lys Arg Pro Gly Phe Arg Arg 
65                  70                  75                  80  


Gln Ala Ser Leu Ser Gln Ser Ile Arg Lys Ser Thr Ala Gln Trp Phe 
                85                  90                  95      


Gly Val Ser Gly Asp Trp Glu Gly Lys Arg Gln Asn Trp His Arg Arg 
            100                 105                 110         


Ser Leu His His Cys Ser Val His Tyr Gly Arg Leu Lys Ala Ser Cys 
        115                 120                 125             


Gln Arg Glu Leu Glu Leu Pro Ser Gln Glu Val Pro Ser Phe Gln Gly 
    130                 135                 140                 


Thr Glu Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu 
145                 150                 155                 160 


Ala Arg Gly Arg Ala Phe Arg His Pro Asp Glu Val Asp Arg Pro His 
                165                 170                 175     


Ala Ala His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe 
            180                 185                 190         


Thr Ser Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Ile 
        195                 200                 205             


Ser Val Ala His Met Ser Phe Gln Ala Ala Ala Ala Leu Leu Lys Gly 
    210                 215                 220                 


Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg His Val Lys Arg 
225                 230                 235                 240 


Ser Phe Ala Tyr Pro Ser Phe Leu Glu Glu Asp Ala Val Asp Gly Ala 
                245                 250                 255     


Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met 
            260                 265                 270         


Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg 
        275                 280                 285             


Gly Val Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val His Ile 
    290                 295                 300                 


Pro Leu Lys Glu Tyr Ser Gly Gly Arg Ala Leu Gly Pro Gly Thr Gln 
305                 310                 315                 320 


Arg Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg 
                325                 330                 335     


Lys Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg 
            340                 345                 350         


Ser Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser 
        355                 360                 365             


Phe Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His 
    370                 375                 380                 


Ile Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val 
385                 390                 395                 400 


Gly Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Lys Asn Arg Gly 
                405                 410                 415     


Val Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Ile Gly 
            420                 425                 430         


Pro Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys 
        435                 440                 445             


Ile Arg Lys Asp Gln Gln Ile Glu Gln Leu Val Arg Arg Glu Arg Asp 
    450                 455                 460                 


Ile Glu Arg Thr Ser Gly Cys Cys Val Gln Asn Asp Arg Ser Gly Cys 
465                 470                 475                 480 


Ile Gln Thr Leu Lys Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val 
                485                 490                 495     


Lys Trp Gln Asn Asp Thr Gly Pro Ser Asp Lys Ser Asp Leu Ser Gln 
            500                 505                 510         


Lys Gln Pro Ser Ala Val Val Cys His Gln Asp Pro Arg Thr Cys Glu 
        515                 520                 525             


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
    530                 535                 540                 


Trp Pro Ile Cys Thr Glu Gln Ala Gln Ser Asn His Thr Gly Leu Leu 
545                 550                 555                 560 


His Ile Asp Cys Lys Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
                565                 570                 575     


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
            580                 585                 590         


Tyr Phe His Glu Asp Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
        595                 600                 605             


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
    610                 615                 620                 


Phe Tyr Arg Ile Trp Leu Ser Leu Phe Leu His Ala Gly Ile Val His 
625                 630                 635                 640 


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
                645                 650                 655     


Lys Leu Ala Gly Trp His Arg Ile Ser Ile Ile Phe Ile Leu Ser Gly 
            660                 665                 670         


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
        675                 680                 685             


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
    690                 695                 700                 


Glu Leu Phe Gln Ser Trp Gln Leu Leu Glu Arg Pro Trp Lys Ala Phe 
705                 710                 715                 720 


Phe Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
                725                 730                 735     


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Met 
            740                 745                 750         


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
        755                 760                 765             


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Val Phe Ala 
    770                 775                 780                 


Gly Leu Phe Ala Ser Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
785                 790                 795                 800 


Trp Pro Trp Ile Glu Tyr Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
                805                 810                 815     


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His Asp Tyr Lys Asp His 
            820                 825                 830         


Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
        835                 840                 845             


Lys 
    


<210>  200
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  T7 Epitope

<400>  200

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      


<210>  201
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  Triple FLAG Epitope

<400>  201

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


