                         SEQUENCE LISTING

<110>  Bayer AG
 
<120>  NOVEL ANTI-SEMA3A ANTIBODIES AND USES THEREOF

<130>  BHC201071

<160>  885  

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Asp Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys His Thr Gly Ile Gly Ala Asn Ser Ala Gly Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  2

Ser Tyr Pro Met Gly 
1               5   


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  3

Gly Ile Asp Asp Asp Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ala Val 
1               5                   10                  15      


Lys Gly 
        


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  4

His Thr Gly Ile Gly Ala Asn Ser Ala Gly Ser Ile Asp Ala 
1               5                   10                  


<210>  5
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  5

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Gly Gly Ser Tyr Thr Gly Ser Tyr 
            20                  25                  30          


Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val 
        35                  40                  45              


Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Leu Ser Gly Thr Thr Asn Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ala Asp Asn Ser Gly 
                85                  90                  95      


Asp Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  6

Ser Gly Gly Gly Ser Tyr Thr Gly Ser Tyr Tyr Tyr Gly 
1               5                   10              


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  7

Tyr Asn Asn Lys Arg Pro Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  8

Gly Ser Ala Asp Asn Ser Gly Asp Ala 
1               5                   


<210>  9
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  9
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatccta tgggctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtggccggc atcgacgacg atggcgatag cgatacaaga      180

tacgcccctg ccgtgaaggg cagagccacc atctccagag acaacagcaa gaacaccgtg      240

tacctgcaga tgaacagcct gagagccgag gacaccgccg tgtactattg tgccaagcac      300

acaggcatcg gcgccaattc tgccggctct attgatgcct ggggccaggg aacactggtc      360

acagtttctt ca                                                          372


<210>  10
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  10
agctatccta tgggc                                                        15


<210>  11
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  11
ggcatcgacg acgatggcga tagcgataca agatacgccc ctgccgtgaa gggc             54


<210>  12
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  12
cacacaggca tcggcgccaa ttctgccggc tctattgatg cc                          42


<210>  13
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  13
agctatgagc tgacacagcc tccaagcgtg tccgtgtctc ctggacagac cgccagaatc       60

acatgtagcg gcggaggcag ctacaccggc agctactact atggctggta tcagcagaag      120

cccggacagg cccctgtgac cgtgatctac tacaacaaca agcggcccag cgacatcccc      180

gagagatttt ctggctctct gagcggcacc accaacacac tgacaatctc tggcgtgcag      240

gccgaggacg aggccgatta ctattgtggc agcgccgata atagcggcga cgcctttggc      300

accggcacca aagttacagt gcta                                             324


<210>  14
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  14
agcggcggag gcagctacac cggcagctac tactatggc                              39


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  15
tacaacaaca agcggcccag c                                                 21


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  16
ggcagcgccg ataatagcgg cgacgcc                                           27


<210>  17
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Asp Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys His Thr Gly Ile Gly Ala Asn Ser Ala Gly Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  18

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Gly Gly Ser Tyr Thr Gly Ser Tyr 
            20                  25                  30          


Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val 
        35                  40                  45              


Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Leu Ser Gly Thr Thr Asn Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ala Asp Asn Ser Gly 
                85                  90                  95      


Asp Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  19
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  19
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatccta tgggctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtggccggc atcgacgacg atggcgatag cgatacaaga      180

tacgcccctg ccgtgaaggg cagagccacc atctccagag acaacagcaa gaacaccgtg      240

tacctgcaga tgaacagcct gagagccgag gacaccgccg tgtactattg tgccaagcac      300

acaggcatcg gcgccaattc tgccggctct attgatgcct ggggccaggg aacactggtc      360

acagtttctt cagccagcac caagggcccc agcgtgttcc ctctggcccc tagcagcaag      420

agcacatctg gcggaacagc cgccctgggc tgcctcgtga aggactactt tcccgagccc      480

gtgaccgtgt cctggaactc tggcgctctg acaagcggcg tgcacacctt tccagccgtg      540

ctgcagagca gcggcctgta ctctctgagc agcgtcgtga cagtgcccag cagctctctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

aaggtggaac ccaagagctg cgacaagacc cacacctgtc ccccttgtcc tgcccccgaa      720

ctgctgggag gcccttccgt gttcctgttc cccccaaagc ccaaggacac cctgatgatc      780

agccggaccc ccgaagtgac ctgcgtggtg gtggatgtgt cccacgagga ccctgaagtg      840

aagttcaatt ggtacgtgga cggcgtggaa gtgcacaacg ccaagaccaa gcctagagag      900

gaacagtaca acagcaccta ccgggtggtg tccgtgctga cagtgctgca ccaggactgg      960

ctgaacggca aagagtacaa gtgcaaggtg tccaacaagg ccctgcctgc ccccatcgag     1020

aaaaccatca gcaaggccaa gggccagccc cgcgaacccc aggtgtacac actgccccca     1080

agcagggacg agctgaccaa gaaccaggtg tccctgacct gtctcgtgaa aggcttctac     1140

ccctccgata tcgccgtgga atgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

accccccctg tgctggacag cgacggctca ttcttcctgt acagcaagct gaccgtggac     1260

aagtcccggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1320

aaccactaca cccagaagtc cctgagcctg agccctggc                            1359


<210>  20
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  20
agctatgagc tgacacagcc tccaagcgtg tccgtgtctc ctggacagac cgccagaatc       60

acatgtagcg gcggaggcag ctacaccggc agctactact atggctggta tcagcagaag      120

cccggacagg cccctgtgac cgtgatctac tacaacaaca agcggcccag cgacatcccc      180

gagagatttt ctggctctct gagcggcacc accaacacac tgacaatctc tggcgtgcag      240

gccgaggacg aggccgatta ctattgtggc agcgccgata atagcggcga cgcctttggc      300

accggcacca aagttacagt gctaggccag cctaaagccg cccctagcgt gaccctgttc      360

cctccaagca gcgaggaact gcaggccaac aaggccaccc tcgtgtgcct gatcagcgac      420

ttctatcctg gcgccgtgac cgtggcctgg aaggccgata gctctcctgt gaaggccggc      480

gtggaaacca ccacccctag caagcagagc aacaacaaat acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      600

ggcagcaccg tggaaaagac agtggcccct accgagtgca gc                         642


<210>  21
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Asp Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys His Thr Gly Ile Gly Ala Asn Ser Ala Gly Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  22

Ser Tyr Pro Met Gly 
1               5   


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  23

Gly Ile Asp Asp Asp Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ala Val 
1               5                   10                  15      


Lys Gly 
        


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  24

His Thr Gly Ile Gly Ala Asn Ser Ala Gly Ser Ile Asp Ala 
1               5                   10                  


<210>  25
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  25

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Gly Gly Ser Tyr Thr Gly Ser Tyr 
            20                  25                  30          


Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val 
        35                  40                  45              


Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Leu Ser Gly Thr Thr Asn Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ala Asp Asn Ser Gly 
                85                  90                  95      


Asp Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  26

Ser Gly Gly Gly Ser Tyr Thr Gly Ser Tyr Tyr Tyr Gly 
1               5                   10              


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  27

Tyr Asn Asn Lys Arg Pro Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  28

Gly Ser Ala Asp Asn Ser Gly Asp Ala 
1               5                   


<210>  29
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  29
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatccta tgggctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtggccggc atcgacgacg atggcgatag cgatacaaga      180

tacgcccctg ccgtgaaggg cagagccacc atctccagag acaacagcaa gaacaccgtg      240

tacctgcaga tgaacagcct gagagccgag gacaccgccg tgtactattg tgccaagcac      300

acaggcatcg gcgccaattc tgccggctct attgatgcct ggggccaggg aacactggtc      360

acagtttctt ca                                                          372


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  30
agctatccta tgggc                                                        15


<210>  31
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  31
ggcatcgacg acgatggcga tagcgataca agatacgccc ctgccgtgaa gggc             54


<210>  32
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  32
cacacaggca tcggcgccaa ttctgccggc tctattgatg cc                          42


<210>  33
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  33
agctatgagc tgacacagcc tccaagcgtg tccgtgtctc ctggacagac cgccagaatc       60

acatgtagcg gcggaggcag ctacaccggc agctactact atggctggta tcagcagaag      120

cccggacagg cccctgtgac cgtgatctac tacaacaaca agcggcccag cgacatcccc      180

gagagatttt ctggctctct gagcggcacc accaacacac tgacaatctc tggcgtgcag      240

gccgaggacg aggccgatta ctattgtggc agcgccgata atagcggcga cgcctttggc      300

accggcacca aagttacagt gcta                                             324


<210>  34
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  34
agcggcggag gcagctacac cggcagctac tactatggc                              39


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  35
tacaacaaca agcggcccag c                                                 21


<210>  36
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  36
ggcagcgccg ataatagcgg cgacgcc                                           27


<210>  37
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Asp Gly Asp Ser Asp Thr Arg Tyr Ala Pro Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys His Thr Gly Ile Gly Ala Asn Ser Ala Gly Ser Ile Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr 
        115                 120                 125             


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
    130                 135                 140                 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
            180                 185                 190         


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
    210                 215                 220                 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
                245                 250                 255     


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
        275                 280                 285             


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
    290                 295                 300                 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
            340                 345                 350         


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
        355                 360                 365             


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
    370                 375                 380                 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
385                 390                 395                 400 


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
                405                 410                 415     


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
            420                 425                 430         


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445             


<210>  38
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  38

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Gly Gly Ser Tyr Thr Gly Ser Tyr 
            20                  25                  30          


Tyr Tyr Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Thr Val 
        35                  40                  45              


Ile Tyr Tyr Asn Asn Lys Arg Pro Ser Asp Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Leu Ser Gly Thr Thr Asn Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Ala Asp Asn Ser Gly 
                85                  90                  95      


Asp Ala Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Glu 
        115                 120                 125             


Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln Gly 
145                 150                 155                 160 


Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met Ala 
                165                 170                 175     


Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu 
        195                 200                 205             


Ser Arg Ala Asp Cys Ser 
    210                 


<210>  39
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  39
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatccta tgggctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtggccggc atcgacgacg atggcgatag cgatacaaga      180

tacgcccctg ccgtgaaggg cagagccacc atctccagag acaacagcaa gaacaccgtg      240

tacctgcaga tgaacagcct gagagccgag gacaccgccg tgtactattg tgccaagcac      300

acaggcatcg gcgccaattc tgccggctct attgatgcct ggggccaggg aacactggtc      360

acagtttctt cagccaagac cacccccccc agcgtgtacc ctctggctcc tggatctgcc      420

gcccagacca acagcatggt caccctgggc tgcctcgtga agggctactt ccctgagcct      480

gtgaccgtga cctggaacag cggctctctg tctagcggcg tgcacacctt tccagccgtg      540

ctgcagagcg acctgtacac cctgagcagc agcgtgaccg tgcctagcag cacctggcct      600

agcgagacag tgacctgcaa cgtggcccac cctgccagca gcacaaaggt ggacaagaaa      660

atcgtgcccc gggactgcgg ctgcaagccc tgtatctgta ccgtgcccga ggtgtccagc      720

gtgttcatct tcccacccaa gcccaaggac gtgctgacca tcaccctgac ccccaaagtg      780

acctgtgtgg tggtggacat cagcaaggac gaccccgagg tgcagttcag ttggttcgtg      840

gacgacgtgg aagtgcacac agcccagacc cagcccagag aggaacagtt caacagcacc      900

ttcagaagcg tgtccgagct gcccatcatg caccaggact ggctgaacgg caaagagttc      960

aagtgcagag tgaacagcgc cgccttccct gcccccatcg agaaaaccat ctccaagacc     1020

aagggcagac ccaaggcccc tcaggtgtac acaatccccc cacccaaaga acagatggcc     1080

aaggacaagg tgtccctgac ctgcatgatc accgatttct tcccagagga catcaccgtg     1140

gaatggcagt ggaacggcca gcccgccgag aactacaaga acacccagcc tatcatggac     1200

accgacggca gctacttcgt gtacagcaag ctgaacgtgc agaagtccaa ctgggaggcc     1260

ggcaacacct tcacctgtag cgtgctgcac gagggcctgc acaatcacca caccgagaag     1320

tccctgtccc acagccctgg caag                                            1344


<210>  40
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  40
agctatgagc tgacacagcc tccaagcgtg tccgtgtctc ctggacagac cgccagaatc       60

acatgtagcg gcggaggcag ctacaccggc agctactact atggctggta tcagcagaag      120

cccggacagg cccctgtgac cgtgatctac tacaacaaca agcggcccag cgacatcccc      180

gagagatttt ctggctctct gagcggcacc accaacacac tgacaatctc tggcgtgcag      240

gccgaggacg aggccgatta ctattgtggc agcgccgata atagcggcga cgcctttggc      300

accggcacca aagttacagt gctaggccag cccaagagca gccctagcgt gaccctgttc      360

cctccaagca gcgaggaact ggaaacaaac aaggccaccc tcgtgtgcac catcaccgac      420

ttctaccccg gcgtcgtgac cgtggactgg aaggtggacg gcaccccagt gacccagggc      480

atggaaacca cccagcccag caagcagagc aacaacaagt acatggccag cagctacctg      540

accctgaccg ccagagcctg ggagagacac agctcctaca gctgccaagt gacccacgag      600

ggccacaccg tggaaaagag cctgagcaga gccgactgca gc                         642


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  42

Ser Tyr Gly Met His 
1               5   


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  43

Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Met Gly 
1               5                   10                  15      


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  44

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Val 
1               5                   10          


<210>  45
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  45

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  46

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  47

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  48

Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Val 
1               5                   10          


<210>  49
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  49
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gatagcgtga tgggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggatgcctt cgatgtgtgg ggccagggaa cactggttac cgtttcttca      360


<210>  50
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  50
agctatggca tgcac                                                        15


<210>  51
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  51
gccatcggca caggcggcga tacctactat gccgatagcg tgatgggc                    48


<210>  52
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  52
agggacgact acaccagcag ggatgccttc gatgtg                                 36


<210>  53
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  53
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgctgcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg atagcctgaa cggctatgtg      300

gttttcggcg gaggcaccaa gctgaccgtg cta                                   333


<210>  54
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  54
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  55
tacgacgacc tgctgcctag c                                                 21


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  56
gccgcctggg acgatagcct gaacggctat gtggtt                                 36


<210>  57
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  58
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  58

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  59
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  59
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctatggca tgcactgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gatagcgtga tgggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggatgcctt cgatgtgtgg ggccagggaa cactggttac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggccccta gcagcaagag cacatctggc      420

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gctctctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      660

aagagctgcg acaagaccca cacctgtccc ccttgtcctg cccccgaact gctgggaggc      720

ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc      780

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      840

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac      900

agcacctacc gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaacggcaaa      960

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgagaa aaccatcagc     1020

aaggccaagg gccagccccg cgaaccccag gtgtacacac tgcccccaag cagggacgag     1080

ctgaccaaga accaggtgtc cctgacctgt ctcgtgaaag gcttctaccc ctccgatatc     1140

gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggacagcg acggctcatt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1260

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagtccc tgagcctgag ccctggc                                         1347


<210>  60
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  60
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgctgcctag cggcgtgccc      180

gatagatttt ctggcagcaa gagcggcaca agcgccagcc tggctatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcgcc gcctgggacg atagcctgaa cggctatgtg      300

gttttcggcg gaggcaccaa gctgaccgtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  61
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  62

Ser Tyr Glu Met Asn 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  63

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  64

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  65

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  66

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  67

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  68

Ser Ser Tyr Ala Gly Ser Asn Pro Tyr Val Val 
1               5                   10      


<210>  69
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  69
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctc tatcggctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  70
agctacgaga tgaac                                                        15


<210>  71
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  71
ggcatcagct ggaatagcgg ctctatcggc tacgccgaca gcgtgaaggg c                51


<210>  72
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  72
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  73
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  73
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactactgc agcagctatg ccggcagcaa cccctacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  74
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  74
accggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  75
ggcaacagca acagacccag c                                                 21


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  76
agcagctatg ccggcagcaa cccctacgtt gtg                                    33


<210>  77
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  78
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  78

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  79
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  79
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctc tatcggctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggc                               1356


<210>  80
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  80
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtaccg gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat ctctggactg      240

agatctgagg acgaggccga ctactactgc agcagctatg ccggcagcaa cccctacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  81
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  81

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Tyr Tyr Asp Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Asn Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  82

Asp Tyr Ala Met Ser 
1               5   


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  83

Trp Ile Tyr Tyr Asp Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  84

Leu Asn Gly Asp Phe Asp Tyr 
1               5           


<210>  85
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  85

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  86
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  86

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Asp Val Ser 
1               5                   10              


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  87

Ala Asp Ser His Arg Pro Ser 
1               5           


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  88

Gly Ala Trp Asp Ser Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  89
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  89
gaagttcagc tgctggaatc tggcggcgga ctggttcaaa caggcggctc tctgagactg       60

agctgtgccg cctctggctt caccttcagc gattacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtcctgg atctactacg acagcggcag caagtactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgcgc caagctgaac      300

ggcgacttcg actattgggg ccagggcaca ctggtcacag tctcttca                   348


<210>  90
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  90
gattacgcca tgagc                                                        15


<210>  91
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  91
tggatctact acgacagcgg cagcaagtac tacgccgaca gcgtgaaggg c                51


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  92
ctgaacggcg acttcgacta t                                                 21


<210>  93
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  93
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc aacaacgacg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac gccgacagcc acagacctag cggcgtgcca      180

gatagattca gcggctctaa gagcggcaca tctgccagcc tggccatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcggc gcctgggatt ctagcctgag cggctatgtt      300

tttggcggag gcaccaagct gaccgtgcta                                       330


<210>  94
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  94
agcggcagca gctccaacat cggcaacaac gacgtgtcc                              39


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  95
gccgacagcc acagacctag c                                                 21


<210>  96
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  96
ggcgcctggg attctagcct gagcggctat gtt                                    33


<210>  97
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  97

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Tyr Tyr Asp Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Asn Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  98
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  98

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  99
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  99
gaagttcagc tgctggaatc tggcggcgga ctggttcaaa caggcggctc tctgagactg       60

agctgtgccg cctctggctt caccttcagc gattacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtcctgg atctactacg acagcggcag caagtactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actattgcgc caagctgaac      300

ggcgacttcg actattgggg ccagggcaca ctggtcacag tctcttcagc cagcaccaag      360

ggccccagcg tgttccctct ggcccctagc agcaagagca catctggcgg aacagccgcc      420

ctgggctgcc tcgtgaagga ctactttccc gagcccgtga ccgtgtcctg gaactctggc      480

gctctgacaa gcggcgtgca cacctttcca gccgtgctgc agagcagcgg cctgtactct      540

ctgagcagcg tcgtgacagt gcccagcagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggaacccaa gagctgcgac      660

aagacccaca cctgtccccc ttgtcctgcc cccgaactgc tgggaggccc ttccgtgttc      720

ctgttccccc caaagcccaa ggacaccctg atgatcagcc ggacccccga agtgacctgc      780

gtggtggtgg atgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc      840

gtggaagtgc acaacgccaa gaccaagcct agagaggaac agtacaacag cacctaccgg      900

gtggtgtccg tgctgacagt gctgcaccag gactggctga acggcaaaga gtacaagtgc      960

aaggtgtcca acaaggccct gcctgccccc atcgagaaaa ccatcagcaa ggccaagggc     1020

cagccccgcg aaccccaggt gtacacactg cccccaagca gggacgagct gaccaagaac     1080

caggtgtccc tgacctgtct cgtgaaaggc ttctacccct ccgatatcgc cgtggaatgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac     1200

ggctcattct tcctgtacag caagctgacc gtggacaagt cccggtggca gcagggcaac     1260

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1320

agcctgagcc ctggc                                                      1335


<210>  100
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  100
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc aacaacgacg tgtcctggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac gccgacagcc acagacctag cggcgtgcca      180

gatagattca gcggctctaa gagcggcaca tctgccagcc tggccatctc tggactgaga      240

tctgaggacg aggccgacta ctattgcggc gcctgggatt ctagcctgag cggctatgtt      300

tttggcggag gcaccaagct gaccgtgcta ggccagccta aagccgcccc tagcgtgacc      360

ctgttccctc caagcagcga ggaactgcag gccaacaagg ccaccctcgt gtgcctgatc      420

agcgacttct atcctggcgc cgtgaccgtg gcctggaagg ccgatagctc tcctgtgaag      480

gccggcgtgg aaaccaccac ccctagcaag cagagcaaca acaaatacgc cgccagcagc      540

tacctgagcc tgacccccga gcagtggaag tcccacagat cctacagctg ccaagtgacc      600

cacgagggca gcaccgtgga aaagacagtg gcccctaccg agtgcagc                   648


<210>  101
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  101

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  102

Ser Tyr Glu Met Asn 
1               5   


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  103

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  104

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  105
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  105

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  106

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  107

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  108

Ser Ser Tyr Ala Gly Ser Asn Pro Tyr Val Val 
1               5                   10      


<210>  109
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  109
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctc tatcggctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  110
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  110
agctacgaga tgaac                                                        15


<210>  111
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  111
ggcatcagct ggaatagcgg ctctatcggc tacgccgaca gcgtgaaggg c                51


<210>  112
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  112
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  113
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  113
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt tctagctacg ccggcagcaa cccctacgtg      300

gtgtttggcg gaggcaccaa gctgacagtt cta                                   333


<210>  114
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  114
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  115
ggcaacagca acagacccag c                                                 21


<210>  116
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  116
tctagctacg ccggcagcaa cccctacgtg gtg                                    33


<210>  117
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  117

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  118
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  118

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  119
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  119
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctc tatcggctac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggc                               1356


<210>  120
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  120
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt tctagctacg ccggcagcaa cccctacgtg      300

gtgtttggcg gaggcaccaa gctgacagtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  121
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  121

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  122

Ser Tyr Ala Met Ser 
1               5   


<210>  123
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  123

Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  124
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  124

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  125
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  125

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  126
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  126

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  127

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  128
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  128

Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Val 
1               5                   10          


<210>  129
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  129
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc attggcacag gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  130
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  130
agctacgcca tgagc                                                        15


<210>  131
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  131
gccattggca caggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  132
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  132
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  133
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  133
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cggctatgtt      300

gttttcggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  134
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  134
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  135
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  135
tacgacgacc tgcggcctag c                                                 21


<210>  136
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  136
gccgcctggg acgacagcct gaacggctat gttgtt                                 36


<210>  137
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  137

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  138
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  138

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  139
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  139
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc attggcacag gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggccccta gcagcaagag cacatctggc      420

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gctctctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      660

aagagctgcg acaagaccca cacctgtccc ccttgtcctg cccccgaact gctgggaggc      720

ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc      780

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      840

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac      900

agcacctacc gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaacggcaaa      960

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgagaa aaccatcagc     1020

aaggccaagg gccagccccg cgaaccccag gtgtacacac tgcccccaag cagggacgag     1080

ctgaccaaga accaggtgtc cctgacctgt ctcgtgaaag gcttctaccc ctccgatatc     1140

gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggacagcg acggctcatt cttcctgtac agcaagctga ccgtggacaa gtcccggtgg     1260

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagtccc tgagcctgag ccctggc                                         1347


<210>  140
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  140
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cggctatgtt      300

gttttcggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  141
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  141

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  142

Ser Tyr Ala Met Ser 
1               5   


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  143

Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  144

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  145
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  145

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  146

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  147

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  148
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  148

Ala Ala Trp Asp Asp Ser Leu Asn Asp Tyr Val Val 
1               5                   10          


<210>  149
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  149
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  150
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  150
agctacgcca tgagc                                                        15


<210>  151
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  151
gccatcggca caggcggcga tacctactat gccgactctg tgaagggc                    48


<210>  152
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  152
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  153
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  153
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgactacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  154
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  154
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  155
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  155
tacgacgacc tgcggcctag c                                                 21


<210>  156
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  156
gccgcctggg acgacagcct gaacgactac gttgtg                                 36


<210>  157
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  157

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  158
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  158

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  159
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  159
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  160
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  160
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgactacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  161
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  161

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  162

Ser Tyr Ala Met Ser 
1               5   


<210>  163
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  163

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  164
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  164

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  165
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  165

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Ile Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  166

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  167

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  168
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  168

Ala Ala Trp Asp Asp Ser Leu Asn Asp Ile Val Val 
1               5                   10          


<210>  169
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  169
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  170
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  170
agctacgcca tgagc                                                        15


<210>  171
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  171
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  172
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  172
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  173
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  173
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgacatcgtt      300

gttttcggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  174
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  174
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  175
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  175
tacgacgacc tgcggcctag c                                                 21


<210>  176
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  176
gccgcctggg acgacagcct gaacgacatc gttgtt                                 36


<210>  177
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  177

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  178
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  178

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Ile Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  179
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  179
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  180
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  180
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgacatcgtt      300

gttttcggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  181
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  181

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  182

Ser Tyr Ala Met Ser 
1               5   


<210>  183
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  183

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  184
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  184

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  185
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  185

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  186
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  186

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  187

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  188
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  188

Ala Ala Trp Asp Asp Ser Leu Asn Val Tyr Pro Val 
1               5                   10          


<210>  189
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  189
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  190
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  190
agctacgcca tgagc                                                        15


<210>  191
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  191
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  192
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  192
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  193
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  193
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgtgtaccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  194
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  194
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  195
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  195
tacgacgacc tgcggcctag c                                                 21


<210>  196
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  196
gccgcctggg acgacagcct gaacgtgtac cctgtt                                 36


<210>  197
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  197

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  198
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  198

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  199
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  199
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  200
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  200
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgtgtaccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  201
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  201

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  202

Ser Tyr Ala Met Ser 
1               5   


<210>  203
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  203

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  204
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  204

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  205
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  205

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Ile Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  206
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  206

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  207

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  208
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  208

His Ala Trp Asp Asp Ser Leu Asn Asp Ile Val Val 
1               5                   10          


<210>  209
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  209
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  210
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  210
agctacgcca tgagc                                                        15


<210>  211
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  211
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  212
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  212
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  213
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  213
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgacatcgtg      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  214
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  214
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  215
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  215
tacgacgacc tgcggcctag c                                                 21


<210>  216
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  216
cacgcctggg acgacagcct gaacgacatc gtggtt                                 36


<210>  217
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  217

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  218
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  218

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Ile Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  219
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  219
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  220
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  220
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgacatcgtg      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  221
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  221

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  222
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  222

Ser Tyr Ala Met Ser 
1               5   


<210>  223
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  223

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  224
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  224

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  225
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  225

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  226
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  226

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  227

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  228
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  228

His Ala Trp Asp Asp Ser Leu Asn Asp Tyr Pro Val 
1               5                   10          


<210>  229
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  229
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  230
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  230
agctacgcca tgagc                                                        15


<210>  231
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  231
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  232
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  232
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  233
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  233
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgactaccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  234
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  234
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  235
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  235
tacgacgacc tgcggcctag c                                                 21


<210>  236
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  236
cacgcctggg acgacagcct gaacgactac cctgtt                                 36


<210>  237
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  237

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  238
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  238

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  239
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  239
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  240
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  240
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgactaccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  241
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  241

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  242
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  242

Ser Tyr Ala Met Ser 
1               5   


<210>  243
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  243

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  244
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  244

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  245
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  245

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  246
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  246

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  247

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  248
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  248

His Ala Trp Asp Asp Ser Leu Asn Val Tyr Pro Val 
1               5                   10          


<210>  249
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  249
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  250
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  250
agctacgcca tgagc                                                        15


<210>  251
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  251
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  252
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  252
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  253
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  253
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgtgtaccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  254
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  254
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  255
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  255
tacgacgacc tgcggcctag c                                                 21


<210>  256
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  256
cacgcctggg acgacagcct gaacgtgtac cctgtt                                 36


<210>  257
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  257

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  258
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  258

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  259
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  259
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  260
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  260
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgtgtaccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  261
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  261

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  262
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  262

Ser Tyr Ala Met Ser 
1               5   


<210>  263
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  263

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  264
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  264

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  265
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  265

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Ile Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  266
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  266

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  267
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  267

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  268
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  268

His Ala Trp Asp Asp Ser Leu Asn Val Ile Pro Val 
1               5                   10          


<210>  269
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  269
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  270
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  270
agctacgcca tgagc                                                        15


<210>  271
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  271
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  272
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  272
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  273
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  273
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgtgatccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  274
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  274
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  275
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  275
tacgacgacc tgcggcctag c                                                 21


<210>  276
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  276
cacgcctggg acgacagcct gaacgtgatc cctgtt                                 36


<210>  277
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  277

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  278
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  278

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Ile Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  279
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  279
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  280
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  280
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgtgatccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  281
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  281

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  282
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  282

Ser Tyr Ala Met Leu 
1               5   


<210>  283
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  283

Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  284
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  284

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  285
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  285

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  286
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  286

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  287
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  287

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  288
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  288

Ala Ala Trp Asp Asp Ser Leu Asn Asp Tyr Val Val 
1               5                   10          


<210>  289
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  289
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgctgtgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  290
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  290
agctacgcca tgctg                                                        15


<210>  291
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  291
gccatcggca caggcggcga tacctactat gccgactctg tgaagggc                    48


<210>  292
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  292
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  293
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  293
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgactacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  294
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  294
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  295
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  295
tacgacgacc tgcggcctag c                                                 21


<210>  296
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  296
gccgcctggg acgacagcct gaacgactac gttgtg                                 36


<210>  297
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  297

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  298
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  298

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  299
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  299
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgctgtgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  300
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  300
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgactacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  301
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  301

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  302
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  302

Ser Tyr Ala Met Leu 
1               5   


<210>  303
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  303

Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  304
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  304

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  305
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  305

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  306
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  306

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  307

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  308
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  308

Ala Ala Trp Asp Asp Ser Leu Asn Val Tyr Val Val 
1               5                   10          


<210>  309
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  309
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgctgtgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  310
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  310
agctacgcca tgctg                                                        15


<210>  311
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  311
gccatcggca caggcggcga tacctactat gccgactctg tgaagggc                    48


<210>  312
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  312
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  313
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  313
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgtgtacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  314
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  314
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  315
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  315
tacgacgacc tgcggcctag c                                                 21


<210>  316
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  316
gccgcctggg acgacagcct gaacgtgtac gttgtg                                 36


<210>  317
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  317

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  318
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  318

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  319
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  319
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgctgtgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggcacag gcggcgatac ctactatgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  320
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  320
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgtgtacgtt      300

gtgtttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  321
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  321

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  322
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  322

Ser Tyr Ala Met Ser 
1               5   


<210>  323
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  323

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  324
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  324

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  325
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  325

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  326
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  326

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  327
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  327

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  328
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  328

His Ala Trp Asp Asp Ser Leu Asn Val Tyr Pro Val 
1               5                   10          


<210>  329
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  329
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  330
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  330
agctacgcca tgagc                                                        15


<210>  331
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  331
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  332
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  332
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  333
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  333
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgtgtaccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  334
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  334
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  335
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  335
tacgacgacc tgcggcctag c                                                 21


<210>  336
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  336
cacgcctggg acgacagcct gaacgtgtac cctgtt                                 36


<210>  337
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  337

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  338
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  338

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys His Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Tyr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  339
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  339
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  340
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  340
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ctattgtcac gcctgggacg acagcctgaa cgtgtaccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  341
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  341

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  342
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  342

Ser Tyr Ala Met Ser 
1               5   


<210>  343
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  343

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  344
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  344

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  345
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  345

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Ile Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  346
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  346

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  347
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  347

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  348
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  348

Ala Ala Trp Asp Asp Ser Leu Asn Asp Ile Pro Val 
1               5                   10          


<210>  349
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  349
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  350
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  350
agctacgcca tgagc                                                        15


<210>  351
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  351
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  352
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  352
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  353
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  353
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgacatccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  354
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  354
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  355
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  355
tacgacgacc tgcggcctag c                                                 21


<210>  356
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  356
gccgcctggg acgacagcct gaacgacatc cctgtt                                 36


<210>  357
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  357

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  358
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  358

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Asp Ile Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  359
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  359
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  360
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  360
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgacatccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  361
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  361

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  362
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  362

Ser Tyr Ala Met Ser 
1               5   


<210>  363
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  363

Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  364
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  364

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr 
1               5                   10          


<210>  365
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  365

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Ile Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  366
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  366

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  367
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  367

Tyr Asp Asp Leu Arg Pro Ser 
1               5           


<210>  368
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  368

Ala Ala Trp Asp Asp Ser Leu Asn Val Ile Pro Val 
1               5                   10          


<210>  369
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  369
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360


<210>  370
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  370
agctacgcca tgagc                                                        15


<210>  371
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  371
gccatcggct atggcggcga tacctactac gccgactctg tgaagggc                    48


<210>  372
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  372
agggacgact acaccagcag ggacgccttc gattat                                 36


<210>  373
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  373
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgtgatccct      300

gtttttggcg gaggcaccaa gctgaccgtt cta                                   333


<210>  374
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  374
agcggcagca gctccaacat cggcagcaac accgtgaac                              39


<210>  375
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  375
tacgacgacc tgcggcctag c                                                 21


<210>  376
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  376
gccgcctggg acgacagcct gaacgtgatc cctgtt                                 36


<210>  377
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  377

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Tyr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  378
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  378

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Ile Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  379
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  379
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttttac agctacgcca tgagctgggt ccgacaggcc      120

cctggaaaag gccttgaatg ggtgtccgcc atcggctatg gcggcgatac ctactacgcc      180

gactctgtga agggcagatt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgagagc cgaggacacc gccgtgtact attgcgccag aagggacgac      300

tacaccagca gggacgcctt cgattattgg ggccagggca cactggtcac cgtttcttca      360

gccagcacca agggccccag cgtgttccct ctggcccctt gtagcagaag caccagcgag      420

tctacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gcagcctggg caccaagacc      600

tacacctgta acgtggacca caagcccagc aacaccaagg tggacaagcg ggtggaatct      660

aagtacggcc ctccctgccc tccttgccca gcccctgaat ttctgggcgg accctccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccaggaagat cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggg cctgcccagc tccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcctccaa gccaggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcagactg accgtggaca agagccggtg gcaggaaggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtctctga gcctgggcaa g                                               1341


<210>  380
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  380
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caacatcggc agcaacaccg tgaactggta tcagcagctg      120

cctggcacag cccctaaact gctgatctac tacgacgacc tgcggcctag cggcgtgcca      180

gatagatttt ctggcagcaa gagcggcacc tctgccagcc tggctatttc tggactgcag      240

agcgaggacg aggccgacta ttattgtgcc gcctgggacg acagcctgaa cgtgatccct      300

gtttttggcg gaggcaccaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  381
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  381

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  382
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  382

Ser Tyr Glu Met Asn 
1               5   


<210>  383
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  383

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  384
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  384

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  385
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  385

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  386
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  386

Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  387
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  387

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  388
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  388

Ser Ser Tyr Ala Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  389
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  389
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  390
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  390
agctacgaga tgaac                                                        15


<210>  391
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  391
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  392
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  392
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  393
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  393
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc cgatattggc gccggatacg acgtgcactg gtatcagcaa      120

ctgcctggca cagcccctaa gctgctgatc tacggcaaca gcaacagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgc agcagctacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  394
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  394
acaggcagca gctccgatat tggcgccgga tacgacgtgc ac                          42


<210>  395
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  395
ggcaacagca acagacctag c                                                 21


<210>  396
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  396
agcagctacg ctggccccaa tccttacgtg gtg                                    33


<210>  397
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  397

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  398
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  398

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  399
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  399
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  400
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  400
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc cgatattggc gccggatacg acgtgcactg gtatcagcaa      120

ctgcctggca cagcccctaa gctgctgatc tacggcaaca gcaacagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgc agcagctacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  401
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  401

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  402
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  402

Ser Tyr Glu Met Asn 
1               5   


<210>  403
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  403

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  404
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  404

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  405
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  405

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ile 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  406
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  406

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  407

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  408
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  408

Gln Ser Tyr Ala Gly Ile Asn Pro Tyr Val Val 
1               5                   10      


<210>  409
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  409
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  410
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  410
agctacgaga tgaac                                                        15


<210>  411
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  411
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  412
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  412
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  413
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  413
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagagctacg ccggcatcaa cccctacgtg      300

gtgtttggcg gaggcaccaa gctgacagtt cta                                   333


<210>  414
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  414
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  415
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  415
ggcaacagca acagacccag c                                                 21


<210>  416
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  416
cagagctacg ccggcatcaa cccctacgtg gtg                                    33


<210>  417
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  417

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  418
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  418

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ile 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  419
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  419
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  420
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  420
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagagctacg ccggcatcaa cccctacgtg      300

gtgtttggcg gaggcaccaa gctgacagtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  421
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  421

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  422
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  422

Ser Tyr Glu Met Asn 
1               5   


<210>  423
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  423

Gly Ile Ser Trp Asn Ser Gly Trp Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  424
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  424

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  425
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  425

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  426
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  426

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  427
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  427

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  428
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  428

Gln Ser Tyr Ala Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  429
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  429
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgatttcagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcggctac      180

gccgatagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  430
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  430
agctacgaga tgaac                                                        15


<210>  431
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  431
ggcatcagct ggaatagcgg ctggatcggc tacgccgata gcgtgaaggg c                51


<210>  432
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  432
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  433
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  433
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  434
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  434
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  435
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  435
ggcaacagca acagacccag c                                                 21


<210>  436
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  436
cagtcttacg ctggccccaa tccttacgtg gtg                                    33


<210>  437
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  437

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  438
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  438

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  439
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  439
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgatttcagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcggctac      180

gccgatagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  440
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  440
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  441
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  441

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  442
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  442

Ser Tyr Glu Met Asn 
1               5   


<210>  443
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  443

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  444
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  444

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  445
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  445

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  446
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  446

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  447
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  447

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  448
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  448

Gln Ser Tyr Ala Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  449
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  449
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgatttcagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  450
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  450
agctacgaga tgaac                                                        15


<210>  451
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  451
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  452
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  452
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  453
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  453
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  454
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  454
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  455
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  455
ggcaacagca acagacccag c                                                 21


<210>  456
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  456
cagtcttacg ctggccccaa tccttacgtg gtg                                    33


<210>  457
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  457

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  458
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  458

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  459
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  459
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgatttcagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  460
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  460
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  461
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  461

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  462
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  462

Ser Tyr Glu Met Asn 
1               5   


<210>  463
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  463

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  464
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  464

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  465
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  465

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  466
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  466

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  467

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  468
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  468

Gln Ser Tyr Ala Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  469
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  469
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  470
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  470
agctacgaga tgaac                                                        15


<210>  471
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  471
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  472
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  472
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  473
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  473
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  474
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  474
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  475
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  475
ggcaacagca acagacccag c                                                 21


<210>  476
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  476
cagtcttacg ctggccccaa tccttacgtg gtg                                    33


<210>  477
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  477

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  478
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  478

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  479
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  479
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  480
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  480
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  481
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  481

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  482
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  482

Ser Tyr Glu Met Asn 
1               5   


<210>  483
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  483

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  484
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  484

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  485
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  485

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  486
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  486

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  487
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  487

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  488
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  488

Gln Ser Tyr Ala Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  489
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  489
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgacttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  490
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  490
agctacgaga tgaac                                                        15


<210>  491
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  491
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  492
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  492
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  493
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  493
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  494
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  494
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  495
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  495
ggcaacagca acagacccag c                                                 21


<210>  496
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  496
cagtcttacg ctggccccaa tccttacgtg gtg                                    33


<210>  497
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  497

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  498
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  498

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  499
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  499
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgacttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  500
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  500
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt cagtcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  501
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  501

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  502
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  502

Ser Tyr Glu Met Asn 
1               5   


<210>  503
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  503

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  504
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  504

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  505
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  505

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ile 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  506
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  506

Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  507
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  507

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  508
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  508

Gln Ser Tyr Ala Gly Ile Asn Pro Tyr Val Val 
1               5                   10      


<210>  509
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  509
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  510
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  510
agctacgaga tgaac                                                        15


<210>  511
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  511
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  512
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  512
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  513
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  513
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc cgatattggc gccggatacg acgtgcactg gtatcagcaa      120

ctgcctggca cagcccctaa gctgctgatc tacggcaaca gcaacagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgt cagagctacg ccggcatcaa cccctacgtg      300

gtgtttggcg gaggcaccaa gctgacagtt cta                                   333


<210>  514
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  514
acaggcagca gctccgatat tggcgccgga tacgacgtgc ac                          42


<210>  515
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  515
ggcaacagca acagacctag c                                                 21


<210>  516
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  516
cagagctacg ccggcatcaa cccctacgtg gtg                                    33


<210>  517
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  517

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  518
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  518

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ile 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  519
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  519
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  520
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  520
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc cgatattggc gccggatacg acgtgcactg gtatcagcaa      120

ctgcctggca cagcccctaa gctgctgatc tacggcaaca gcaacagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgt cagagctacg ccggcatcaa cccctacgtg      300

gtgtttggcg gaggcaccaa gctgacagtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  521
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  521

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  522
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  522

Ser Tyr Glu Met Asn 
1               5   


<210>  523
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  523

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  524
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  524

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  525
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  525

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Glu Gly Ile 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  526
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  526

Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  527
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  527

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  528
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  528

Ser Ser Tyr Glu Gly Ile Asn Pro Tyr Val Val 
1               5                   10      


<210>  529
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  529
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgacttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  530
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  530
agctacgaga tgaac                                                        15


<210>  531
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  531
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  532
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  532
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  533
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  533
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc cgatattggc gccggatacg acgtgcactg gtatcagcaa      120

ctgcctggca cagcccctaa gctgctgatc tacggcaaca gcaacagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgc agcagctacg agggcatcaa cccctacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  534
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  534
acaggcagca gctccgatat tggcgccgga tacgacgtgc ac                          42


<210>  535
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  535
ggcaacagca acagacctag c                                                 21


<210>  536
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  536
agcagctacg agggcatcaa cccctacgtg gtg                                    33


<210>  537
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  537

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  538
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  538

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Glu Gly Ile 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  539
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  539
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgacttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  540
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  540
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc cgatattggc gccggatacg acgtgcactg gtatcagcaa      120

ctgcctggca cagcccctaa gctgctgatc tacggcaaca gcaacagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgc agcagctacg agggcatcaa cccctacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  541
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  541

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  542
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  542

Ser Tyr Glu Met Asn 
1               5   


<210>  543
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  543

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  544
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  544

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  545
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  545

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Glu Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  546
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  546

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  547
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  547

Gly Ala Ser Asn Arg Pro Ser 
1               5           


<210>  548
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  548

Ser Ser Tyr Glu Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  549
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  549
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgatttcagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  550
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  550
agctacgaga tgaac                                                        15


<210>  551
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  551
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  552
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  552
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  553
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  553
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcgcca gcaatagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgc agcagctacg agggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  554
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  554
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  555
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  555
ggcgccagca atagacctag c                                                 21


<210>  556
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  556
agcagctacg agggccccaa tccttacgtg gtg                                    33


<210>  557
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  557

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  558
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  558

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Glu Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  559
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  559
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cgatttcagc agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  560
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  560
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcgcca gcaatagacc tagcggcgtg      180

cccgatagat tcagcggctc taagtctggc acaagcgcca gcctggccat tactggactg      240

caggccgaag atgaggccga ctactactgc agcagctacg agggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  561
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  561

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  562
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  562

Ser Tyr Glu Met Asn 
1               5   


<210>  563
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  563

Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  564
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  564

Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
1               5                   10                  


<210>  565
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  565

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  566
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  566

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  567
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  567

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  568
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  568

Ser Ser Tyr Ala Gly Pro Asn Pro Tyr Val Val 
1               5                   10      


<210>  569
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  569
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttca                                                              369


<210>  570
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  570
agctacgaga tgaac                                                        15


<210>  571
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  571
ggcatcagct ggaatagcgg ctggatcgac tacgccgaca gcgtgaaggg c                51


<210>  572
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  572
agcggctaca gcagctcttg gtttgacccc gacttcgact at                          42


<210>  573
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  573
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt agctcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt cta                                   333


<210>  574
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  574
acaggcagca gctccaatat cggagccggc tatgacgtgc ac                          42


<210>  575
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  575
ggcaacagca acagacccag c                                                 21


<210>  576
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  576
agctcttacg ctggccccaa tccttacgtg gtg                                    33


<210>  577
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  577

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Trp Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Ser Ser Ser Trp Phe Asp Pro Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  578
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  578

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Pro 
                85                  90                  95      


Asn Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  579
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  579
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcgat agctacgaga tgaactgggt ccgacaggcc      120

cctggcaaag gccttgaatg ggtgtccggc atcagctgga atagcggctg gatcgactac      180

gccgacagcg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaagcggc      300

tacagcagct cttggtttga ccccgacttc gactattggg gccagggcac actggtcaca      360

gtctcttcag ccagcaccaa gggccccagc gtgttccctc tggcccctag cagcaagagc      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaactctgg cgctctgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag      660

gtggaaccca agagctgcga caagacccac acctgtcccc cttgtcctgc ccccgaactg      720

ctgggaggcc cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatcagc      780

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc tgaagtgaag      840

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc tagagaggaa      900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgacag tgctgcacca ggactggctg      960

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgagaaa     1020

accatcagca aggccaaggg ccagccccgc gaaccccagg tgtacacact gcccccaagc     1080

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaagg cttctacccc     1140

tccgatatcg ccgtggaatg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac cgtggacaag     1260

tcccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagtccct gagcctgagc cctggcaag                            1359


<210>  580
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  580
cagtctgttc tgacacagcc tccatctgtg tctggcgccc ctggacagag agtgaccatc       60

agctgtacag gcagcagctc caatatcgga gccggctatg acgtgcactg gtatcagcag      120

ctgcctggca cagcccctaa actgctgatc tacggcaaca gcaacagacc cagcggcgtg      180

cccgatagat tttccggctc taagagcggc acaagcgcca gcctggctat tactggactg      240

caggccgagg acgaggccga ctactactgt agctcttacg ctggccccaa tccttacgtg      300

gtgtttggcg gcggaacaaa gctgaccgtt ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  581
<211>  990
<212>  PRT
<213>  Homo sapiens

<400>  581

His His His His His His Lys Asn Asn Val Pro Arg Leu Lys Leu Ser 
1               5                   10                  15      


Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu 
            20                  25                  30          


Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser 
        35                  40                  45              


Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asp Leu Val 
    50                  55                  60                  


Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg 
65                  70                  75                  80  


Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala 
                85                  90                  95      


Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala 
            100                 105                 110         


Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly 
        115                 120                 125             


His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser His Phe Glu 
    130                 135                 140                 


Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser 
145                 150                 155                 160 


Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met 
                165                 170                 175     


Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile 
            180                 185                 190         


Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Lys Phe Ile 
        195                 200                 205             


Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp Asp Lys Val 
    210                 215                 220                 


Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys 
225                 230                 235                 240 


Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly 
                245                 250                 255     


His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu 
            260                 265                 270         


Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu 
        275                 280                 285             


Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys Asn Pro Val 
    290                 295                 300                 


Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala 
305                 310                 315                 320 


Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro 
                325                 330                 335     


Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly 
            340                 345                 350         


Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly 
        355                 360                 365             


Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala 
    370                 375                 380                 


Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met Asn Asn Arg 
385                 390                 395                 400 


Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val 
                405                 410                 415     


Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile 
            420                 425                 430         


Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu 
        435                 440                 445             


Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe 
    450                 455                 460                 


Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln 
465                 470                 475                 480 


Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His 
                485                 490                 495     


Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg 
            500                 505                 510         


Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg Tyr Phe Pro 
        515                 520                 525             


Thr Ala Lys Arg Ala Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro 
    530                 535                 540                 


Leu Thr His Cys Ser Asp Leu His His Asp Asn His His Gly His Ser 
545                 550                 555                 560 


Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe Leu 
                565                 570                 575     


Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe Gln 
            580                 585                 590         


Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp Asp His Ile 
        595                 600                 605             


Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln Gln Lys Asp 
    610                 615                 620                 


Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Ile Gln Thr 
625                 630                 635                 640 


Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu Glu 
                645                 650                 655     


Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr Lys Glu Met 
            660                 665                 670         


Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe Met 
        675                 680                 685             


Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys Glu 
    690                 695                 700                 


Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly His 
705                 710                 715                 720 


Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu Asn Lys Lys 
                725                 730                 735     


Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser Val 
            740                 745                 750         


Asp Ile Glu Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr 
        755                 760                 765             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    770                 775                 780                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
785                 790                 795                 800 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                805                 810                 815     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            820                 825                 830         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        835                 840                 845             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    850                 855                 860                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
865                 870                 875                 880 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                885                 890                 895     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            900                 905                 910         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        915                 920                 925             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    930                 935                 940                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
945                 950                 955                 960 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                965                 970                 975     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985                 990 


<210>  582
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  582

Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asp Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Lys Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys Asn Pro Val Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr 
        435                 440                 445             


Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Ala Arg Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  583
<211>  563
<212>  PRT
<213>  Mus musculus (Mouse)

<400>  583

Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Val Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Ile Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Ala Arg Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  584
<211>  563
<212>  PRT
<213>  Rattus norvegicus (Rat)

<400>  584

Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Val Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Ala Arg Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  585
<211>  563
<212>  PRT
<213>  Canis lupus familiaris (dog)

<400>  585

Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Ser Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Gln Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Thr Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Pro Ile Ser Ala Met Glu Leu Ser Thr Lys Gln His Gln 
465                 470                 475                 480 


Leu Tyr Ala Gly Ser Pro Ala Gly Leu Ala Gln Leu Pro Leu Gln Arg 
                485                 490                 495     


Cys Ala Ala Tyr Gly Arg Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ala Ala Cys Ser Arg Tyr Phe Pro Ala 
        515                 520                 525             


Ala Lys Ala Arg Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  586
<211>  563
<212>  PRT
<213>  Macaca fascicularis (Cynomolgus monkey)

<400>  586

Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Ile Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Ala Arg Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  587
<211>  563
<212>  PRT
<213>  Sus scrofa (Pig)

<400>  587

Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Thr Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Val Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Val Gly Ser Ala Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Ala Arg Thr Arg Ala Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  588
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  site
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  588

Ser Tyr Xaa Met Xaa 
1               5   


<210>  589
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  589

Ser Tyr Ala Met Xaa 
1               5   


<210>  590
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  site
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  590

Ala Ile Gly Xaa Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Xaa Gly 
1               5                   10                  15      


<210>  591
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  591

Ala Ile Gly Xaa Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  592
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  site
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  592

Gly Ile Ser Trp Asn Ser Gly Xaa Ile Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  593
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  593

Gly Ile Ser Trp Asn Ser Gly Trp Ile Xaa Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  594
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  594

Arg Asp Asp Tyr Thr Ser Arg Asp Ala Phe Asp Xaa 
1               5                   10          


<210>  595
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  595

Thr Gly Ser Ser Ser Xaa Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  596
<211>  7
<212>  PRT
<213>  artificial

<220>
<221>  site
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  596

Tyr Asp Asp Leu Xaa Pro Ser 
1               5           


<210>  597
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  597

Gly Xaa Ser Asn Arg Pro Ser 
1               5           


<210>  598
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  site
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  598

Xaa Ala Trp Asp Asp Ser Leu Asn Xaa Xaa Xaa Val 
1               5                   10          


<210>  599
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  antibody sequence


<220>
<221>  site
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  site
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  site
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  599

Xaa Ser Tyr Xaa Gly Xaa Asn Pro Tyr Val Val 
1               5                   10      


<210>  600
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  600

Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr Lys 
1               5                   10                  15      


Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala Asn 
            20                  25                  30          


Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg Leu 
        35                  40                  45              


Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asp Leu Val Asn Ile 
    50                  55                  60                  


Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg Asp 
65                  70                  75                  80  


Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn Phe 
                85                  90                  95      


Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys Gly 
            100                 105                 110         


Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Ile Gly His His 
        115                 120                 125             


Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser His Phe Glu Asn Gly 
    130                 135                 140                 


Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu Leu 
145                 150                 155                 160 


Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly Arg 
                165                 170                 175     


Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg Thr 
            180                 185                 190         


Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Lys Phe Ile Ser Ala 
        195                 200                 205             


His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr Phe 
    210                 215                 220                 


Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala Thr 
225                 230                 235                 240 


His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His Arg 
                245                 250                 255     


Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile Cys 
            260                 265                 270         


Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu Gln 
        275                 280                 285             


Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys Asn Pro Val Val Tyr 
    290                 295                 300                 


Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val Cys 
305                 310                 315                 320 


Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr Ala 
                325                 330                 335     


His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg Val 
            340                 345                 350         


Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly Phe 
        355                 360                 365             


Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg Ser 
    370                 375                 380                 


His Pro Ala Met Tyr Asn Pro Val Phe Pro Met Asn Asn Arg Pro Ile 
385                 390                 395                 400 


Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val Asp 
                405                 410                 415     


Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly Thr 
            420                 425                 430         


Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr Trp 
        435                 440                 445             


Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg Glu 
    450                 455                 460                 


Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln Leu 
465                 470                 475                 480 


Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg Cys 
                485                 490                 495     


Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp Pro 
            500                 505                 510         


Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg Tyr Phe Pro Thr Ala 
        515                 520                 525             


Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Leu Thr 
    530                 535                 540                 


His Cys Ser Asp Leu His His Asp Asn His His Gly His Ser Pro Glu 
545                 550                 555                 560 


Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe Leu Glu Cys 
                565                 570                 575     


Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe Gln Arg Arg 
            580                 585                 590         


Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp Asp His Ile Ile Arg 
        595                 600                 605             


Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln Gln Lys Asp Ser Gly 
    610                 615                 620                 


Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Ile Gln Thr Leu Leu 
625                 630                 635                 640 


Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu Glu Leu Leu 
                645                 650                 655     


His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr Lys Glu Met Ser Asn 
            660                 665                 670         


Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe Met Gln Leu 
        675                 680                 685             


Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys Glu Gln Val 
    690                 695                 700                 


Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly His Thr Pro 
705                 710                 715                 720 


Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu Asn Lys Lys Gly Arg 
                725                 730                 735     


Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser Val 
            740                 745                 750 


<210>  601
<211>  752
<212>  PRT
<213>  Mus musculus

<400>  601

Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Glu Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Val Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Leu Gln His His Asp Asn His His Gly Pro Ser 
545                 550                 555                 560 


Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe Leu 
                565                 570                 575     


Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe Gln 
            580                 585                 590         


Arg Arg Asn Glu Asp Arg Lys Glu Glu Ile Arg Met Gly Asp His Ile 
        595                 600                 605             


Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu Gln Lys Lys Asp 
    610                 615                 620                 


Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Met Gln Thr 
625                 630                 635                 640 


Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu Glu 
                645                 650                 655     


Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Ile Lys Glu Met 
            660                 665                 670         


Ser Ser Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe Met 
        675                 680                 685             


Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys Glu 
    690                 695                 700                 


Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly His 
705                 710                 715                 720 


Ser Gln Gly Ser Ser Asn Lys Trp Lys His Met Gln Glu Ser Lys Lys 
                725                 730                 735     


Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser Val 
            740                 745                 750         


<210>  602
<211>  772
<212>  PRT
<213>  Macaca fascicularis

<400>  602

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     


Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Ile Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His 
                565                 570                 575     


His Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser 
            580                 585                 590         


Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr 
        595                 600                 605             


Trp Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val 
    610                 615                 620                 


Asp Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu 
625                 630                 635                 640 


Gln Arg Lys Asp Ser Gly Ser Tyr Leu Cys His Ala Val Glu His Gly 
                645                 650                 655     


Phe Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu 
            660                 665                 670         


His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys 
        675                 680                 685             


Thr Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr 
    690                 695                 700                 


Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp 
705                 710                 715                 720 


Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln 
                725                 730                 735     


Arg Pro Gly His Thr Gln Gly Asn Ser Asn Lys Trp Lys His Leu Gln 
            740                 745                 750         


Glu Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala 
        755                 760                 765             


Pro Arg Ser Val 
    770         


<210>  603
<211>  752
<212>  PRT
<213>  Rattus norvegicus

<400>  603

Asn Tyr Ala Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile Glu Val Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Gln Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Val Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Leu Gln His His Asp Asn His His Gly His Ser 
545                 550                 555                 560 


Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe Leu 
                565                 570                 575     


Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp Gln Phe Gln 
            580                 585                 590         


Arg Arg Asn Glu Asp Arg Lys Glu Glu Ile Arg Val Gly Asp His Ile 
        595                 600                 605             


Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu Gln Lys Lys Asp 
    610                 615                 620                 


Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe Met Gln Thr 
625                 630                 635                 640 


Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His Leu Glu Glu 
                645                 650                 655     


Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr Lys Glu Met 
            660                 665                 670         


Ser Ser Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg Asp Phe Met 
        675                 680                 685             


Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys Glu 
    690                 695                 700                 


Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Gly His 
705                 710                 715                 720 


Ser Gln Gly Ser Ser Asn Lys Trp Lys His Met Gln Glu Ser Lys Lys 
                725                 730                 735     


Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser Val 
            740                 745                 750         


<210>  604
<211>  772
<212>  PRT
<213>  Sus scrofa

<400>  604

Met Gly Trp Phe Ser Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asp Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Thr Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     


Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Val Gly Ser Ala Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His 
                565                 570                 575     


Arg Gly His Asn Phe Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser 
            580                 585                 590         


Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr 
        595                 600                 605             


Trp Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val 
    610                 615                 620                 


Asp Asp His Ile Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu 
625                 630                 635                 640 


Gln Arg Lys Asp Ser Gly Ser Tyr Leu Cys His Ala Val Glu His Gly 
                645                 650                 655     


Phe Met Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu 
            660                 665                 670         


His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Ser Ser Lys 
        675                 680                 685             


Thr Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Ile Trp Tyr 
    690                 695                 700                 


Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp 
705                 710                 715                 720 


Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln 
                725                 730                 735     


Arg Pro Gly His Thr Gln Gly Asn Ser Asn Lys Trp Lys His Leu Gln 
            740                 745                 750         


Glu Asn Lys Lys Cys Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala 
        755                 760                 765             


Pro Arg Ser Val 
    770         


<210>  605
<211>  772
<212>  PRT
<213>  Canis lupus familiaris

<400>  605

Met Gly Trp Leu Ala Arg Ile Ala Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Thr Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Ser Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asn Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Gln Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asp Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Thr Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     


Asn Asn Arg Pro Ile Met Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Pro Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln His Gln Leu Tyr Ala Gly Ser Pro Ala Gly Leu Ala Gln Leu 
            500                 505                 510         


Pro Leu Gln Arg Cys Ala Ala Tyr Gly Arg Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ala Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Ala Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn His 
                565                 570                 575     


His Ser His Ser Leu Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser 
            580                 585                 590         


Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr 
        595                 600                 605             


Trp Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val 
    610                 615                 620                 


Asp Asp His Ile Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu 
625                 630                 635                 640 


Gln Arg Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly 
                645                 650                 655     


Phe Met Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu 
            660                 665                 670         


His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys 
        675                 680                 685             


Thr Lys Glu Ile Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr 
    690                 695                 700                 


Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp 
705                 710                 715                 720 


Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln 
                725                 730                 735     


Arg Pro Gly His Thr Gln Gly Asn Ser Asn Lys Trp Lys His Leu Gln 
            740                 745                 750         


Glu Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala 
        755                 760                 765             


Pro Arg Ser Val 
    770         

	
<210> 	606
<400> 	606
000	
<210> 	607
<400> 	607
000	
<210> 	608
<400> 	608
000	
<210> 	609
<400> 	609
000	
<210> 	610
<400> 	610
000	
<210> 	611
<400> 	611
000	
<210> 	612
<400> 	612
000	
<210> 	613
<400> 	613
000	
<210> 	614
<400> 	614
000	
<210> 	615
<400> 	615
000	
<210> 	616
<400> 	616
000	
<210> 	617
<400> 	617
000	
<210> 	618
<400> 	618
000	
<210> 	619
<400> 	619
000	
<210> 	620
<400> 	620
000	
<210> 	621
<400> 	621
000	
<210> 	622
<400> 	622
000	
<210> 	623
<400> 	623
000	
<210> 	624
<400> 	624
000	
<210> 	625
<400> 	625
000	
<210> 	626
<400> 	626
000	
<210> 	627
<400> 	627
000	
<210> 	628
<400> 	628
000	
<210> 	629
<400> 	629
000	
<210> 	630
<400> 	630
000	
<210> 	631
<400> 	631
000	
<210> 	632
<400> 	632
000	
<210> 	633
<400> 	633
000	
<210> 	634
<400> 	634
000	
<210> 	635
<400> 	635
000	
<210> 	636
<400> 	636
000	
<210> 	637
<400> 	637
000	
<210> 	638
<400> 	638
000	
<210> 	639
<400> 	639
000	
<210> 	640
<400> 	640
000	
<210> 	641
<400> 	641
000	
<210> 	642
<400> 	642
000	
<210> 	643
<400> 	643
000	
<210> 	644
<400> 	644
000	
<210> 	645
<400> 	645
000	
<210> 	646
<400> 	646
000	
<210> 	647
<400> 	647
000	
<210> 	648
<400> 	648
000	
<210> 	649
<400> 	649
000	
<210> 	650
<400> 	650
000	
<210> 	651
<400> 	651
000	
<210> 	652
<400> 	652
000	
<210> 	653
<400> 	653
000	
<210> 	654
<400> 	654
000	
<210> 	655
<400> 	655
000	
<210> 	656
<400> 	656
000	
<210> 	657
<400> 	657
000	
<210> 	658
<400> 	658
000	
<210> 	659
<400> 	659
000	
<210> 	660
<400> 	660
000	
<210> 	661
<400> 	661
000	
<210> 	662
<400> 	662
000	
<210> 	663
<400> 	663
000	
<210> 	664
<400> 	664
000	
<210> 	665
<400> 	665
000	
<210> 	666
<400> 	666
000	
<210> 	667
<400> 	667
000	
<210> 	668
<400> 	668
000	
<210> 	669
<400> 	669
000	
<210> 	670
<400> 	670
000	
<210> 	671
<400> 	671
000	
<210> 	672
<400> 	672
000	
<210> 	673
<400> 	673
000	
<210> 	674
<400> 	674
000	
<210> 	675
<400> 	675
000	
<210> 	676
<400> 	676
000	
<210> 	677
<400> 	677
000	
<210> 	678
<400> 	678
000	
<210> 	679
<400> 	679
000	
<210> 	680
<400> 	680
000	
<210> 	681
<400> 	681
000	
<210> 	682
<400> 	682
000	
<210> 	683
<400> 	683
000	
<210> 	684
<400> 	684
000	
<210> 	685
<400> 	685
000	
<210> 	686
<400> 	686
000	
<210> 	687
<400> 	687
000	
<210> 	688
<400> 	688
000	
<210> 	689
<400> 	689
000	
<210> 	690
<400> 	690
000	
<210> 	691
<400> 	691
000	
<210> 	692
<400> 	692
000	
<210> 	693
<400> 	693
000	
<210> 	694
<400> 	694
000	
<210> 	695
<400> 	695
000	
<210> 	696
<400> 	696
000	
<210> 	697
<400> 	697
000	
<210> 	698
<400> 	698
000	
<210> 	699
<400> 	699
000	
<210> 	700
<400> 	700
000	
<210> 	701
<400> 	701
000	
<210> 	702
<400> 	702
000	
<210> 	703
<400> 	703
000	
<210> 	704
<400> 	704
000	
<210> 	705
<400> 	705
000	
<210> 	706
<400> 	706
000	
<210> 	707
<400> 	707
000	
<210> 	708
<400> 	708
000	
<210> 	709
<400> 	709
000	
<210> 	710
<400> 	710
000	
<210> 	711
<400> 	711
000	
<210> 	712
<400> 	712
000	
<210> 	713
<400> 	713
000	
<210> 	714
<400> 	714
000	
<210> 	715
<400> 	715
000	
<210> 	716
<400> 	716
000	
<210> 	717
<400> 	717
000	
<210> 	718
<400> 	718
000	
<210> 	719
<400> 	719
000	
<210> 	720
<400> 	720
000	
<210> 	721
<400> 	721
000	
<210> 	722
<400> 	722
000	
<210> 	723
<400> 	723
000	
<210> 	724
<400> 	724
000	
<210> 	725
<400> 	725
000	
<210> 	726
<400> 	726
000	
<210> 	727
<400> 	727
000	
<210> 	728
<400> 	728
000	
<210> 	729
<400> 	729
000	
<210> 	730
<400> 	730
000	
<210> 	731
<400> 	731
000	
<210> 	732
<400> 	732
000	
<210> 	733
<400> 	733
000	
<210> 	734
<400> 	734
000	
<210> 	735
<400> 	735
000	
<210> 	736
<400> 	736
000	
<210> 	737
<400> 	737
000	
<210> 	738
<400> 	738
000	
<210> 	739
<400> 	739
000	
<210> 	740
<400> 	740
000	
<210> 	741
<400> 	741
000	
<210> 	742
<400> 	742
000	
<210> 	743
<400> 	743
000	
<210> 	744
<400> 	744
000	
<210> 	745
<400> 	745
000	
<210> 	746
<400> 	746
000	
<210> 	747
<400> 	747
000	
<210> 	748
<400> 	748
000	
<210> 	749
<400> 	749
000	
<210> 	750
<400> 	750
000	
<210> 	751
<400> 	751
000	
<210> 	752
<400> 	752
000	
<210> 	753
<400> 	753
000	
<210> 	754
<400> 	754
000	
<210> 	755
<400> 	755
000	
<210> 	756
<400> 	756
000	
<210> 	757
<400> 	757
000	
<210> 	758
<400> 	758
000	
<210> 	759
<400> 	759
000	
<210> 	760
<400> 	760
000	
<210> 	761
<400> 	761
000	
<210> 	762
<400> 	762
000	
<210> 	763
<400> 	763
000	
<210> 	764
<400> 	764
000	
<210> 	765
<400> 	765
000	
<210> 	766
<400> 	766
000	
<210> 	767
<400> 	767
000	
<210> 	768
<400> 	768
000	
<210> 	769
<400> 	769
000	
<210> 	770
<400> 	770
000	
<210> 	771
<400> 	771
000	
<210> 	772
<400> 	772
000	
<210> 	773
<400> 	773
000	
<210> 	774
<400> 	774
000	
<210> 	775
<400> 	775
000	
<210> 	776
<400> 	776
000	
<210> 	777
<400> 	777
000	
<210> 	778
<400> 	778
000	
<210> 	779
<400> 	779
000	
<210> 	780
<400> 	780
000	
<210> 	781
<400> 	781
000	
<210> 	782
<400> 	782
000	
<210> 	783
<400> 	783
000	
<210> 	784
<400> 	784
000	
<210> 	785
<400> 	785
000	
<210> 	786
<400> 	786
000	
<210> 	787
<400> 	787
000	
<210> 	788
<400> 	788
000	
<210> 	789
<400> 	789
000	
<210> 	790
<400> 	790
000	
<210> 	791
<400> 	791
000	
<210> 	792
<400> 	792
000	
<210> 	793
<400> 	793
000	
<210> 	794
<400> 	794
000	
<210> 	795
<400> 	795
000	
<210> 	796
<400> 	796
000	
<210> 	797
<400> 	797
000	
<210> 	798
<400> 	798
000	
<210> 	799
<400> 	799
000	


<210>  800
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  800


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  801
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  801

Ser Tyr Tyr Met Ser 
1               5   


<210>  802
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  802

Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  803
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  803

Gly Gly Gln Gly Ala Met Asp Tyr 
1               5               


<210>  804
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  804

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  805
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  805

Arg Ala Ser Gln Ser Ile Gly Asp Tyr Leu His 
1               5                   10      


<210>  806
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  806

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  807
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  807

Gln Gln Gly Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  808
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  808
gaagtgcagc tggtggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc tccagagaca acagcaagaa caccctgtac      240

ctgcagatga gcagcctgag agccgaggat accgccgtgt actactgtgt tagaggcgga      300

cagggcgcca tggattattg gggccaggga accacagtga ccgtgtcatc a               351


<210>  809
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  809
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gattaagtac gccagccagt ccatcagcgg catccctgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccatcaccag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  810
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  810

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  811
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  811

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  812
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  812
gaagtgcagc tggtggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc tccagagaca acagcaagaa caccctgtac      240

ctgcagatga gcagcctgag agccgaggat accgccgtgt actactgtgt tagaggcgga      300

cagggcgcca tggattattg gggccaggga accacagtga ccgtgtcatc agccagcacc      360

aagggcccca gcgtgttccc tctggcccct agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct      480

ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tctctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gacaagaccc acacctgtcc cccttgtcct gcccccgaac tgctgggagg cccttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcccccaa gcagggacga gctgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcaagctg accgtggaca agtcccggtg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgagcctga gccctggcaa g                                               1341


<210>  813
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  813
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gattaagtac gccagccagt ccatcagcgg catccctgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccatcaccag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  814
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  814

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  815
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  815

Ser Tyr Tyr Met Ser 
1               5   


<210>  816
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  816

Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  817
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  817

Gly Gly Gln Gly Ala Met Asp Tyr 
1               5               


<210>  818
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  818

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  819
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  819

Arg Ala Ser Gln Ser Ile Gly Asp Tyr Leu His 
1               5                   10      


<210>  820
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  820

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  821
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  821

Gln Gln Gly Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  822
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  822
gaagtgcagc tggtggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg       60

tcttgtgccg cctctggctt cccattcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga gcagcctgag agccgaggat accgccgtgt actactgtgt tagaggcgga      300

cagggcgcca tggattattg gggccaggga accacagtga ccgtgtcatc a               351


<210>  823
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  823
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gattaagtac gccagccagt ccatcagcgg catccctgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccatcaccag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  824
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  824

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  825
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  825

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  826
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  826
gaagtgcagc tggtggaatc tggcggagga ctggttcaac ctggcggctc tctgagactg       60

tcttgtgccg cctctggctt cccattcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga gcagcctgag agccgaggat accgccgtgt actactgtgt tagaggcgga      300

cagggcgcca tggattattg gggccaggga accacagtga ccgtgtcatc agccagcacc      360

aagggcccca gcgtgttccc tctggcccct agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct      480

ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tctctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gacaagaccc acacctgtcc cccttgtcct gcccccgaac tgctgggagg cccttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcccccaa gcagggacga gctgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcaagctg accgtggaca agtcccggtg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgagcctga gccctggcaa g                                               1341


<210>  827
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  827
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gattaagtac gccagccagt ccatcagcgg catccctgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccatcaccag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  828
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  828

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  829
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  829

Ser Tyr Tyr Met Ser 
1               5   


<210>  830
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  830

Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  831
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  831

Gly Gly Gln Gly Ala Met Asp Tyr 
1               5               


<210>  832
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  832

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  833
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  833

Arg Ala Ser Gln Ser Ile Gly Asp Tyr Leu His 
1               5                   10      


<210>  834
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  834

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  835
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  835

Gln Gln Gly Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  836
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  836
gaagtgcagc tggtggaatc tggcggagga ctggttcagc tcggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc tccagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gaaaggtgga      300

cagggcgcca tggactattg gggccaggga acaacagtga ccgtgtcctc a               351


<210>  837
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  837
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gatctactat gccagccagt ccatcagcgg catccccgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccataagcag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  838
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  838

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  839
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  839

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  840
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  840
gaagtgcagc tggtggaatc tggcggagga ctggttcagc tcggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc tccagagaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gaaaggtgga      300

cagggcgcca tggactattg gggccaggga acaacagtga ccgtgtcctc agccagcacc      360

aagggcccca gcgtgttccc tctggcccct agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct      480

ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tctctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gacaagaccc acacctgtcc cccttgtcct gcccccgaac tgctgggagg cccttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcccccaa gcagggacga gctgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcaagctg accgtggaca agtcccggtg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgagcctga gccctggcaa g                                               1341


<210>  841
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  841
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gatctactat gccagccagt ccatcagcgg catccccgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccataagcag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  842
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  842

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Leu Gln Leu Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  843
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  843

Ser Tyr Tyr Met Ser 
1               5   


<210>  844
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  844

Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  845
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  845

Gly Gly Gln Gly Ala Met Asp Tyr 
1               5               


<210>  846
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  846

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  847
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  847

Arg Ala Ser Gln Ser Ile Gly Asp Tyr Leu His 
1               5                   10      


<210>  848
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  848

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  849
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  849

Gln Gln Gly Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  850
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  850
gaagtgcagc tggtggaatc tggcggagga ctgctgcagc ttggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc tccagagaca acagcaagaa caccctgaac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gaaaggtgga      300

cagggcgcca tggactattg gggccaggga acaacagtga ccgtgtcctc a               351


<210>  851
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  851
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gattaagtac gccagccagt ccatcagcgg catccctgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccataagcag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  852
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  852

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Leu Gln Leu Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Lys Ser Gly Gly Tyr Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Gln Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  853
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  853

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  854
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  854
gaagtgcagc tggtggaatc tggcggagga ctgctgcagc ttggcggatc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc agctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gacttgaatg ggtgtccacc atcatcaaga gcggcggcta cgcctactat      180

cccgacagcg tgaaggaccg gttcaccatc tccagagaca acagcaagaa caccctgaac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgt gaaaggtgga      300

cagggcgcca tggactattg gggccaggga acaacagtga ccgtgtcctc agccagcacc      360

aagggcccca gcgtgttccc tctggcccct agcagcaaga gcacatctgg cggaacagcc      420

gccctgggct gcctcgtgaa ggactacttt cccgagcccg tgaccgtgtc ctggaactct      480

ggcgctctga caagcggcgt gcacaccttt ccagccgtgc tgcagagcag cggcctgtac      540

tctctgagca gcgtcgtgac agtgcccagc agctctctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggaacc caagagctgc      660

gacaagaccc acacctgtcc cccttgtcct gcccccgaac tgctgggagg cccttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      780

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cctagagagg aacagtacaa cagcacctac      900

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      960

tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaga aaaccatcag caaggccaag     1020

ggccagcccc gcgaacccca ggtgtacaca ctgcccccaa gcagggacga gctgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta cagcaagctg accgtggaca agtcccggtg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgagcctga gccctggcaa g                                               1341


<210>  855
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  855
gagattgtgc tgacacagtc tcccgccaca ctgtctctta gccctggcga aagagccaca       60

ctgagctgta gagccagcca gagcatcggc gattacctgc actggtatca gcagaagcct      120

ggacaggccc ctcggctgct gattaagtac gccagccagt ccatcagcgg catccctgcc      180

agattttctg gcagcggctc tggcaccgat ttcaccctga ccataagcag cctggaacct      240

gaggacttcg ccgtgtacta ctgccagcag ggctacagct tcccctacac atttggcgga      300

ggcaccaagc tggaaatcaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  856
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  856

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Thr Glu Gly Ser Gly Val Gly Thr Ser Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Leu Gly Gly Gly Asn Pro Leu Asp Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  857
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  857

Ser Tyr Ala Val His 
1               5   


<210>  858
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  858

Ser Thr Glu Gly Ser Gly Val Gly Thr Ser Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  859
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  859

Met Leu Gly Gly Gly Asn Pro Leu Asp Tyr Leu Asp Tyr 
1               5                   10              


<210>  860
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  860

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Glu Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Ser Asp Phe Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Ser Gln Val Phe Gly Gly Gly Thr Gln Val Thr Val Leu 
            100                 105                 110     


<210>  861
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  861

Ser Gly Ser Ser Ser Asn Leu Gly Glu Gly Tyr Asp Val His 
1               5                   10                  


<210>  862
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  862

Tyr Ser Asp Phe Arg Pro Ser 
1               5           


<210>  863
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  863

Ala Ala Trp Asp Asp Ser Leu Ser Ser Gln Val 
1               5                   10      


<210>  864
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  864
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttaga agctatgccg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtgtccagc accgaaggct ctggcgtggg cacaagctac      180

accgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaatgctc      300

ggcggaggca accctctgga ctacctggat tattggggcc agggcaccct ggtcacagtc      360

tcttca                                                                 366


<210>  865
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  865
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caatctcggc gagggctatg acgtgcactg gtatcagcag      120

ctgcctggca aggcccctaa actgctgatc tactacagcg acttcagacc cagcggcgtg      180

tccgatagat tcagcggctc taagagcggc acatctgcca gcctggccat ctctggactg      240

cagagcgaag atgaggccga ctactattgc gccgcctggg atgatagcct gagcagccaa      300

gtttttggcg gcggaaccca agtgaccgtg cta                                   333


<210>  866
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  866

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Thr Glu Gly Ser Gly Val Gly Thr Ser Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Leu Gly Gly Gly Asn Pro Leu Asp Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  867
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  867

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Glu Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Ser Asp Phe Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Ser Gln Val Phe Gly Gly Gly Thr Gln Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  868
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  868
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttaga agctatgccg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtgtccagc accgaaggct ctggcgtggg cacaagctac      180

accgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaatgctc      300

ggcggaggca accctctgga ctacctggat tattggggcc agggcaccct ggtcacagtc      360

tcttcagcca gcaccaaggg ccccagcgtg ttccctctgg cccctagcag caagagcaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc cgaactgctg      720

ggaggccctt ccgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      780

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      840

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcctag agaggaacag      900

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      960

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc     1020

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc cccaagcagg     1080

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaaaggctt ctacccctcc     1140

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgacgg ctcattcttc ctgtacagca agctgaccgt ggacaagtcc     1260

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac     1320

tacacccaga agtccctgag cctgagccct ggcaag                               1356


<210>  869
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  869
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caatctcggc gagggctatg acgtgcactg gtatcagcag      120

ctgcctggca aggcccctaa actgctgatc tactacagcg acttcagacc cagcggcgtg      180

tccgatagat tcagcggctc taagagcggc acatctgcca gcctggccat ctctggactg      240

cagagcgaag atgaggccga ctactattgc gccgcctggg atgatagcct gagcagccaa      300

gtttttggcg gcggaaccca agtgaccgtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  870
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  870

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Thr Glu Gly Ser Gly Val Gly Thr Ser Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Leu Gly Gly Gly Asn Pro Leu Asp Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  871
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  871

Ser Tyr Ala Val His 
1               5   


<210>  872
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  872

Ser Thr Glu Gly Ser Gly Val Gly Thr Ser Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  873
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  873

Met Leu Gly Gly Gly Asn Pro Leu Asp Tyr Leu Asp Tyr 
1               5                   10              


<210>  874
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  874

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Glu Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Ser Asp Phe Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Ser Gln Val Phe Gly Gly Gly Thr Gln Val Thr Val Leu 
            100                 105                 110     


<210>  875
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  875

Ser Gly Ser Ser Ser Asn Leu Gly Glu Gly Tyr Asp Val His 
1               5                   10                  


<210>  876
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  876

Tyr Ser Asp Phe Arg Pro Ser 
1               5           


<210>  877
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  877

Ala Ala Trp Asp Asp Ser Leu Ser Ser Gln Val 
1               5                   10      


<210>  878
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  878
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttaga agctatgccg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtgtccagc accgaaggct ctggcgtggg cacaagctac      180

accgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaatgctc      300

ggcggaggca accctctgga ctacctggat tattggggcc agggcaccct ggtcacagtc      360

tcttca                                                                 366


<210>  879
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  879
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caatctcggc gagggctatg acgtgcactg gtatcagcag      120

ctgcctggca aggcccctaa actgctgatc tactacagcg acttcagacc cagcggcgtg      180

tccgatagat tcagcggctc taagagcggc acatctgcca gcctggccat ctctggactg      240

cagagcgaag atgaggccga ctactattgc gccgcctggg atgatagcct gagcagccaa      300

gtttttggcg gcggaaccca agtgaccgtg cta                                   333


<210>  880
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  880

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Thr Glu Gly Ser Gly Val Gly Thr Ser Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Leu Gly Gly Gly Asn Pro Leu Asp Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Ala Ala Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser 
225                 230                 235                 240 


Gly Ser Ala Ala Ala His His His His His His 
                245                 250     


<210>  881
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  881

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Leu Gly Glu Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Ser Asp Phe Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Ser Gln Val Phe Gly Gly Gly Thr Gln Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  882
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  882
gaagttcagc tgctggaatc tggcggcgga ctggttcaac ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt cacctttaga agctatgccg tgcactgggt ccgacaggcc      120

cctggaaaag gactggaatg ggtgtccagc accgaaggct ctggcgtggg cacaagctac      180

accgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaatgctc      300

ggcggaggca accctctgga ctacctggat tattggggcc agggcaccct ggtcacagtc      360

tcttcagcct ccaccaaggg cccatcggtg ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgcagc gggttctgaa caaaaactca tctcagaaga ggatctgtct      720

ggatcagcgg ccgcccatca tcatcatcat cat                                   753


<210>  883
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody sequence

<400>  883
cagtctgttc tgacacagcc tcctagcgcc tctggcacac ctggacagag agtgaccatc       60

agctgtagcg gcagcagctc caatctcggc gagggctatg acgtgcactg gtatcagcag      120

ctgcctggca aggcccctaa actgctgatc tactacagcg acttcagacc cagcggcgtg      180

tccgatagat tcagcggctc taagagcggc acatctgcca gcctggccat ctctggactg      240

cagagcgaag atgaggccga ctactattgc gccgcctggg atgatagcct gagcagccaa      300

gtttttggcg gcggaaccca agtgaccgtg ctaggccagc ctaaagccgc ccctagcgtg      360

accctgttcc ctccaagcag cgaggaactg caggccaaca aggccaccct cgtgtgcctg      420

atcagcgact tctatcctgg cgccgtgacc gtggcctgga aggccgatag ctctcctgtg      480

aaggccggcg tggaaaccac cacccctagc aagcagagca acaacaaata cgccgccagc      540

agctacctga gcctgacccc cgagcagtgg aagtcccaca gatcctacag ctgccaagtg      600

acccacgagg gcagcaccgt ggaaaagaca gtggccccta ccgagtgcag c               651


<210>  884
<211>  563
<212>  PRT
<213>  Oryctolagus cuniculus (Rabbit)

<400>  884

Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu Lys Leu Ser Tyr 
1               5                   10                  15      


Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe Asn Gly Leu Ala 
            20                  25                  30          


Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser Arg 
        35                  40                  45              


Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val Asn 
    50                  55                  60                  


Ile Lys Asp Phe Gln Lys Ile Ala Trp Pro Val Ser Tyr Thr Arg Arg 
65                  70                  75                  80  


Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Arg Glu Cys Ala Asn 
                85                  90                  95      


Phe Ile Lys Val Leu Lys Val Tyr Asn Gln Thr His Leu Tyr Ala Cys 
            100                 105                 110         


Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Val Gly Ile Gly His 
        115                 120                 125             


His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asp Ser His Phe Glu Asn 
    130                 135                 140                 


Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser Leu 
145                 150                 155                 160 


Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met Gly 
                165                 170                 175     


Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly Gln His His Pro Ile Arg 
            180                 185                 190         


Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile Ser 
        195                 200                 205             


Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Val Tyr 
    210                 215                 220                 


Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Ser Gly Lys Ala 
225                 230                 235                 240 


Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly His 
                245                 250                 255     


Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu Ile 
            260                 265                 270         


Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu Leu 
        275                 280                 285             


Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile Val 
    290                 295                 300                 


Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Arg Gly Ser Ala Val 
305                 310                 315                 320 


Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe Leu Gly Pro Tyr 
                325                 330                 335     


Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Phe Gln Gly Arg 
            340                 345                 350         


Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly Gly 
        355                 360                 365             


Phe Glu Ser Thr Lys Asp Leu Pro Asp Asp Val Ile Thr Phe Ala Arg 
    370                 375                 380                 


Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Asn Arg Pro 
385                 390                 395                 400 


Ile Met Val Lys Thr Asp Val Asn Tyr Gln Phe Thr Gln Ile Val Val 
                405                 410                 415     


Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile Gly 
            420                 425                 430         


Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu Thr 
        435                 440                 445             


Trp His Asp Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe Arg 
    450                 455                 460                 


Glu Pro Thr Thr Ile Ser Ala Met Glu Leu Ser Thr Lys Gln Gln Gln 
465                 470                 475                 480 


Leu Tyr Val Gly Ser Ala Ala Gly Val Ala Gln Leu Pro Leu His Arg 
                485                 490                 495     


Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg Asp 
            500                 505                 510         


Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro Thr 
        515                 520                 525             


Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro Leu 
    530                 535                 540                 


Thr His Cys Ser Asp Gly Gly Ile Glu Gly Arg Met Asp His His His 
545                 550                 555                 560 


His His His 
            


<210>  885
<211>  1689
<212>  DNA
<213>  Oryctolagus cuniculus (Rabbit)

<400>  885
aactatcaga acggcaagaa caacgtgccc cggctgaagc tgagctacaa agagatgctg       60

gaaagcaaca acgtgatcac cttcaacggc ctggccaaca gcagcagcta ccacaccttt      120

ctgctggacg aggaacggtc cagactgtac gtgggagcca aggaccacat cttcagcttc      180

aacctggtca acatcaagga cttccagaaa atcgcctggc ctgtgtccta caccagacgg      240

gatgagtgta aatgggccgg caaggacatc ctgagagagt gcgccaactt catcaaggtg      300

ctgaaggtgt acaatcagac ccacctgtac gcctgtggca ccggcgcttt tcaccctatc      360

tgtacctatg tcggcatcgg ccaccatcct gaggacaata tcttcaagct cgaggacagc      420

cacttcgaga acggcagagg caagagcccc tacgatccca aactgctgac agcctctctg      480

ctgatcgacg gcgagctgta ttctggcaca gccgccgatt tcatgggcag agacttcgcc      540

atcttcagaa ccctgggcca gcatcacccc atcagaaccg agcagcacga cagcagatgg      600

ctgaacgacc ccagattcat cagcgcccat ctgatccccg agagcgacaa ccccgaggac      660

gacaaggtgt acttcttctt ccgggaaaac gccatcgacg gggagcactc tggaaaagcc      720

acacacgcca gaatcggcca gatctgcaag aacgacttcg gcggccacag atccctcgtg      780

aacaagtgga ccaccttcct gaaggcccgg ctgatctgtt ctgtgcccgg acctaatggc      840

atcgataccc acttcgacga gctgcaggac gtgttcctga tgaacagcaa ggaccccaag      900

aatcccatcg tgtacggcgt gttcaccacc agcagcaaca tctttagagg cagcgccgtg      960

tgcatgtaca gcatgtccga tgtgcggaga gtgtttctgg gcccctacgc tcacagagat     1020

ggccccaatt atcagtgggt gccattccag ggcagagtgc cctatcctag acctggcacc     1080

tgtcctagca agacctttgg cggcttcgag agcaccaagg acctgcctga cgatgtgatt     1140

accttcgcca gatctcaccc cgccatgtac aaccctgtgt tccccatcaa caacaggccc     1200

atcatggtca agaccgacgt gaactaccag ttcacccaga tcgtggtgga cagagtggat     1260

gccgaggacg gccagtacga cgtgatgttc atcggcaccg atgtgggcac cgtgctgaaa     1320

gtggtgtcta tccccaaaga gacatggcac gacctggaag aggtgctgct ggaagagatg     1380

accgtgttca gagagcccac caccatctcc gccatggaac tgagcacaaa acagcaacag     1440

ctgtatgtgg gctccgccgc tggtgttgct caactgcctc tgcacagatg cgacatctac     1500

ggcaaagcct gcgccgagtg ttgcctggcc agagatcctt actgtgcctg ggatggcagc     1560

agctgcagca gatactttcc caccgccaag cggagaacca gacggcagga tatcagaaac     1620

ggcgaccctc tgacacactg cagcgacggt ggcatcgagg gccgcatgga tcatcatcat     1680

caccatcat                                                             1689


