б

<110>  ԭƼϺι˾

<120>  CLDN18.2ԭϵ׼;

<130>  0065-PA-045

<160>  93

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 VH

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met Asn Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  2
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 HCDR1

<400>  2

Asn Tyr Val Met Asn 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 HCDR2

<400>  3

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 HCDR3

<400>  4

Leu Tyr Arg Gly Asn Ala Met Asp Tyr 
1               5                   


<210>  5
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 VL

<400>  5

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Val Arg 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Val Tyr Ile Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  6
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E63A67E317B10IMAB362 LCDR1

<400>  6

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  7
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E63A67E317B10IMAB362 LCDR2

<400>  7

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 LCDR3

<400>  8

Gln Asn Val Tyr Ile Tyr Pro Phe Thr 
1               5                   


<210>  9
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 VH

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ile Ser Gly Gly Ile Asn Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Leu Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Val Thr Val Ser Ser 
        115             


<210>  10
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 HCDR1

<400>  10

Arg Tyr Gly Met Ser 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 HCDR2

<400>  11

Thr Ile Ile Ser Gly Gly Ile Asn Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 HCDR3

<400>  12

Leu Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   


<210>  13
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 VL

<400>  13

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  14
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 LCDR3

<400>  14

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  15
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7E3 VH

<400>  15

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Thr Asp Gly Pro Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asn Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  16
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7E314E1217B10 HCDR1

<400>  16

Asn Tyr Ile Ile His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7E314E1217B10 HCDR2

<400>  17

Tyr Ile Asn Pro Tyr Thr Asp Gly Pro Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7E314E1217B10 HCDR3

<400>  18

Leu Asn Arg Gly Asn Ala Met Asp Tyr 
1               5                   


<210>  19
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E1217B10 VH

<400>  19

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Thr Asp Gly Pro Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asn Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  20
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 VL

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Asn 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Leu Tyr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Asp Ile 
            100                 105                 110         


Lys Arg 
        


<210>  21
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 LCDR1

<400>  21

Lys Ser Ser Gln Ser Leu Leu Asn Asn Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  22
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 LCDR2

<400>  22

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 LCDR3

<400>  23

Gln Asn Asp Leu Tyr Tyr Pro Phe Thr 
1               5                   


<210>  24
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  17B10 VL

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  25
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  17B10 LCDR3

<400>  25

Gln Asn Asp Tyr Ser Phe Pro Phe Thr 
1               5                   


<210>  26
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 VH DNA

<400>  26
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact aactatgtta tgaactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactaagtac      180

aatgagaggt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagccttc      240

atggaggtca gcagcctgac ctctgaggac tctgcggtct actactgtgc aagactatat      300

agaggcaatg ctatggacta ctggggtcaa ggaacctcgg tcaccgtctc ctca            354


<210>  27
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 VL DNA

<400>  27
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagtaagaga gaaggtcact       60

ttgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaacttttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gcacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatgt ttatatttat      300

ccgttcacgt tcggtgctgg gaccaagctg gagctgaaac gg                         342


<210>  28
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 VH DNA

<400>  28
gaggtgcagt tggtggagtc tgggggagac ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttaagt cgttatggca tgtcttgggt tcgccagact      120

cctgacaaga ggctggagtg ggtctcaacc attattagtg gtggtattaa cacctactat      180

tcagacagtg tgaaggggcg attctccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgg aagactctac      300

tatggcaatg ctatggacta ctgggggcaa ggaaccgctg tcaccgtctc ctca            354


<210>  29
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 VL DNA

<400>  29
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacacattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat      300

cctctcacgt tcggtgctgg gaccaagctg gagctgaaac gg                         342


<210>  30
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  7E3 VH DNA

<400>  30
gaggtccagt tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact aactatatta tacactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acactgatgg tcctaagtac      180

aatgagaagt tcaaaggcag ggccacactg acttcagaca aatcctccag tacagcctac      240

atggagttca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagactaaat      300

agaggcaatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  31
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  14E1217B10 VH DNA

<400>  31
gaggtgcagc tgcaggagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact aactatatta tacactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acactgatgg tcctaagtac      180

aatgagaagt tcaaaggcag ggccacactg acttcagaca aatcctccag tacagcctac      240

atggagttca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagactaaat      300

agaggcaatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  32
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 VL DNA

<400>  32
gatattgtga tgacccagtc tccatcttcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacaatggaa atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cgctcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tctttattat      300

ccattcacgt tcggctcggg gacaaagttg gacataaaac gg                         342


<210>  33
<211>  342
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  17B10 VL DNA

<400>  33
gatattgtga tgacccagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact       60

atgaactgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg      180

gaatctgggg tccctgatcg gttcacaggc agtggatctg gaacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagtttt      300

ccattcacgt tcggctcggg gacaaagttg gaaataaaac gg                         342


<210>  34
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 H-FR1

<400>  34

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  35
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E314E1217B10 H-FR2

<400>  35

Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  36
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 H-FR3

<400>  36

Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Phe Met Glu 
1               5                   10                  15      


Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  37
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E314E1217B10 H-FR4

<400>  37

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  38
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 L-FR1

<400>  38

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Val Arg 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys 
            20              


<210>  39
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E33A614E1217B10 L-FR2

<400>  39

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  40
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E317B10 L-FR3

<400>  40

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  41
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E33A6 L-FR4

<400>  41

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
1               5                   10      


<210>  42
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  7E314E1217B10 H-FR3

<400>  42

Arg Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  43
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 H-FR1

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser 
            20                  25                  30  


<210>  44
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 H-FR2

<400>  44

Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ser 
1               5                   10                  


<210>  45
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 H-FR3

<400>  45

Arg Phe Ser Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Gly Arg 
            20                  25                  30          


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 H-FR4

<400>  46

Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
1               5                   10      


<210>  47
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 L-FR1

<400>  47

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  48
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  3A6 L-FR3

<400>  48

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr His Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  49
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E1217B10 H-FR1

<400>  49

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  50
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 L-FR1

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  51
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 L-FR3

<400>  51

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  52
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  14E12 L-FR4

<400>  52

Phe Gly Ser Gly Thr Lys Leu Asp Ile Lys Arg 
1               5                   10      


<210>  53
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  17B10 L-FR1

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys 
            20              


<210>  54
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  17B10 L-FR4

<400>  54

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  55
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 VH

<400>  55

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  56
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 VL

<400>  56

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  57
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 HCDR1

<400>  57

Ser Tyr Trp Ile Asn 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 HCDR2

<400>  58

Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  59
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 HCDR3

<400>  59

Ser Trp Arg Gly Asn Ser Phe Asp Tyr 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 LCDR3

<400>  60

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  61
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CLDN18.1

<400>  61
atgtccacca ccacatgcca agtggtggcg ttcctcctgt ccatcctggg gctggccggc       60

tgcatcgcgg ccaccgggat ggacatgtgg agcacccagg acctgtacga caaccccgtc      120

acctccgtgt tccagtacga agggctctgg aggagctgcg tgaggcagag ttcaggcttc      180

accgaatgca ggccctattt caccatcctg ggacttccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcgg ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct caggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagata      720

tacgatggag gtgcccgcac agaggacgag gtacaatctt atccttccaa gcacgactat      780

gtg                                                                    783


<210>  62
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CLDN18.2

<400>  62
atggccgtga ctgcctgtca gggcttgggg ttcgtggttt cactgattgg gattgcgggc       60

atcattgctg ccacctgcat ggaccagtgg agcacccaag acttgtacaa caaccccgta      120

acagctgttt tcaactacca ggggctgtgg cgctcctgtg tccgagagag ctctggcttc      180

accgagtgcc ggggctactt caccctgctg gggctgccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcgg ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct caggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagata      720

tacgatggag gtgcccgcac agaggacgag gtacaatctt atccttccaa gcacgactat      780

gtg                                                                    783


<210>  63
<211>  792
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  СCLDN18.1

<400>  63
atggccacca ccacgtgcca ggtggtaggg cttctcctgt ccctcctggg tctggccggc       60

tgcatagccg ccactgggat ggacatgtgg agcactcaag acctgtatga caacccagtc      120

accgccgtgt tccagtatga agggctctgg aggagttgcg tgcaacagag ctcggggttc      180

accgagtgcc ggccatactt caccatcctg ggccttccag ccatgctgca agctgtacga      240

gccctgatga tcgtgggcat tgttctgggg gtcatcggta tcctcgtgtc catcttcgcc      300

ctgaagtgca ttcgcattgg tagcatggat gactctgcca aggccaagat gactctgact      360

tctgggatct tgttcatcat ctccggcatc tgtgcaatca ttggtgtgtc tgtgtttgcc      420

aacatgctgg tgaccaactt ctggatgtcc acagctaaca tgtacagcgg catgggcggc      480

atgggtggca tggtgcagac cgttcagacc aggtacacct ttggtgcagc tctgttcgtg      540

ggctgggttg ctggaggcct caccctgatt gggggagtga tgatgtgcat cgcctgccgt      600

ggcctgacac cagatgacag caacttcaaa gctgtgtctt accatgcctc tggccaaaat      660

gttgcctaca ggcctggagg ctttaaggcc agcactggct ttgggtccaa caccagaaac      720

aagaagatct acgatggggg tgcccgcaca gaagacgatg aacagtctca tcctaccaag      780

tatgactatg tg                                                          792


<210>  64
<211>  792
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  СCLDN18.2

<400>  64
atgtcggtga ccgcctgcca gggcttgggg tttgtggtgt cactgatcgg gtttgcgggc       60

atcattgcag ccacttgtat ggaccagtgg agcacccagg atttatacaa caacccggtg      120

accgctgtat tcaactacca agggctatgg cgttcatgcg tccgagagag ctctggcttc      180

accgagtgcc gaggctactt caccctgttg gggttgccag ccatgctgca agctgtacga      240

gccctgatga tcgtgggcat tgttctgggg gtcatcggta tcctcgtgtc catcttcgcc      300

ctgaagtgca ttcgcattgg tagcatggat gactctgcca aggccaagat gactctgact      360

tctgggatct tgttcatcat ctccggcatc tgtgcaatca ttggtgtgtc tgtgtttgcc      420

aacatgctgg tgaccaactt ctggatgtcc acagctaaca tgtacagcgg catgggcggc      480

atgggtggca tggtgcagac cgttcagacc aggtacacct ttggtgcagc tctgttcgtg      540

ggctgggttg ctggaggcct caccctgatt gggggagtga tgatgtgcat cgcctgccgt      600

ggcctgacac cagatgacag caacttcaaa gctgtgtctt accatgcctc tggccaaaat      660

gttgcctaca ggcctggagg ctttaaggcc agcactggct ttgggtccaa caccagaaac      720

aagaagatct acgatggggg tgcccgcaca gaagacgatg aacagtctca tcctaccaag      780

tatgactatg tg                                                          792


<210>  65
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ʳз CLDN18.1

<400>  65
atgtccacca ccacatgcca agtggtggcg ttcctcctgt ccatcctggg gctggcgggc       60

tgcatcgcgg ccaccgggat ggacatgtgg agcacccagg acctgtacga caaccccgtc      120

acctctgtgt tccagtacga agggctgtgg aggagctgcg tgaggcagag ctcggggttc      180

accgagtgca ggccctattt caccatcctg ggccttccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcag ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct cgggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagaca      720

tatgatgggg gtgcccacac agaggacgag ttacaatctt atccttccaa gcacgactat      780

gtg                                                                    783


<210>  66
<211>  783
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  ʳзCLDN18.2

<400>  66
atggccgtga ctgcctgtca gggcttgggg ttcgtggttt cactgattgg gattgcgggc       60

atcattgctg ccacctgcat ggaccagtgg agcacccaag acttgtacaa caaccccgtg      120

acagctgtat tcaactacca ggggctgtgg cgctcctgtg tccgagagag ctctggcttc      180

accgagtgca ggggctactt caccctgctg gggctgccag ccatgctgca ggcagtgcga      240

gccctgatga tcgtaggcat cgtcctgggt gccattggcc tcctggtatc catctttgcc      300

ctgaaatgca tccgcattgg cagcatggag gactctgcca aagccaacat gacactgacc      360

tccgggatca tgttcattgt ctcaggtctt tgtgcaattg ctggagtgtc tgtgtttgcc      420

aacatgctgg tgactaactt ctggatgtcc acagctaaca tgtacaccgg catgggtggg      480

atggtgcaga ctgttcagac caggtacaca tttggtgcgg ctctgttcgt gggctgggtc      540

gctggaggcc tcacactaat tgggggtgtg atgatgtgca tcgcctgccg gggcctggca      600

ccagaagaaa ccaactacaa agccgtttct tatcatgcct cgggccacag tgttgcctac      660

aagcctggag gcttcaaggc cagcactggc tttgggtcca acaccaaaaa caagaagaca      720

tatgatgggg gtgcccacac agaggacgag ttacaatctt atccgtccaa gcacgactat      780

gtg                                                                    783


<210>  67
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 HCDR3; 3A6 HCDR3; 7E314E1217B10 HCDR3

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = AsnTyr

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = ArgTyr

<400>  67

Leu Xaa Xaa Gly Asn Ala Met Asp Tyr 
1               5                   


<210>  68
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 HCDR2; 7E314E1217B10 HCDR2

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AsnThr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = ProThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = LysArg

<400>  68

Tyr Ile Asn Pro Tyr Xaa Asp Gly Xaa Lys Tyr Asn Glu Xaa Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 LCDR3; 14E12 LCDR3; 3A6 LCDR3; 17B10 LCDR3

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AspVal

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = LeuTyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = IleSerTyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = PheLeu

<400>  69

Gln Asn Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  70
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E63A67E317B10IMAB362 LCDR2; 14E12 LCDR2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GlyTrp

<400>  70

Xaa Ala Ser Thr Arg Glu Ser 
1               5           


<210>  71
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E63A67E317B10IMAB362 LCDR1; 14E12 LCDR1

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AlaThr

<400>  71

Lys Ser Ser Gln Ser Leu Leu Asn Xaa Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Xaa 
    


<210>  72
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 H-FR1; 3A6 H-FR1; 14E1217B10 H-FR1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = GlyPro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaLys

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = SerThr

<400>  72

Glu Val Gln Leu Xaa Xaa Ser Gly Xaa Xaa Leu Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Xaa Lys Xaa Ser Cys Xaa Ala Ser Gly Xaa Thr Xaa Xaa 
            20                  25                  30  


<210>  73
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E314E1217B10 H-FR2; 3A6 H-FR2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LysThr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = GlySer

<400>  73

Trp Val Xaa Gln Xaa Pro Xaa Xaa Xaa Leu Glu Trp Xaa Xaa 
1               5                   10                  


<210>  74
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E314E1217B10 H-FR4; 3A6 H-FR4

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AlaSer

<400>  74

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  75
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 L-FR1; 3A6 L-FR1; 14E12 L-FR1; 17B10 L-FR1

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = AsnSer

<400>  75

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Xaa Val Xaa Xaa Xaa 
1               5                   10                  15      


Glu Lys Val Thr Xaa Xaa Cys 
            20              


<210>  76
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E317B10 L-FR3; 3A6 L-FR3; 14E12 L-FR3

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AspHis

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaThr

<400>  76

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Xaa Phe Xaa 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  77
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E33A6 L-FR4; 14E12 L-FR4; 17B10 L-FR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleLeu

<400>  77

Phe Gly Xaa Gly Thr Lys Leu Xaa Xaa Lys Arg 
1               5                   10      


<210>  78
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 VH PRT; 3A6 VH PRT; 7E3 VH PRT; 14E1217B10 VH PRT

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = GlyPro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = AlaLys

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AsnArg

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = GlyIleVal

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = IleMet

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = HisAsnSer

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = LysThr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa = ThrTyr

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa = IleAsn

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = GlyTyr

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = GlyAsnThr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AspIle

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = GlyAsn

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = ProThr

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = LysTyr

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa = LysArgSer

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa = PheVal

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = AlaPhe

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = AlaLeu

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = PheMetVal

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = LysThr

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = MetVal

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = AsnTyr

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = ArgTyr

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa = AlaSer

<400>  78

Glu Val Gln Leu Xaa Xaa Ser Gly Xaa Xaa Leu Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Xaa Lys Xaa Ser Cys Xaa Ala Ser Gly Xaa Thr Xaa Xaa Xaa Tyr 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Xaa Gln Xaa Pro Xaa Xaa Xaa Leu Glu Trp Xaa 
        35                  40                  45              


Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Lys Gly Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa Thr Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Ser Ser Leu Xaa Ser Glu Asp Xaa Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Xaa Arg Leu Xaa Xaa Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Xaa Val Thr Val Ser Ser 
        115             


<210>  79
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E67E3 VL PRT; 3A6 VL PRT; 14E12 VL PRT; 17B10 VL PRT

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = GlyTrp

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = AspHis

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = AspVal

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa = LeuTyr

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa = IleSerTyr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa = IleLeu

<400>  79

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Xaa Val Xaa Xaa Xaa 
1               5                   10                  15      


Glu Lys Val Thr Xaa Xaa Cys Lys Ser Ser Gln Ser Leu Leu Asn Xaa 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Xaa Phe Xaa Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Xaa Xaa Xaa Xaa Pro Xaa Thr Phe Gly Xaa Gly Thr Lys Leu Xaa Xaa 
            100                 105                 110         


Lys Arg 
        


<210>  80
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 H-FR3; 7E314E1217B10 H-FR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = PheVal

<400>  80

Xaa Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Xaa Met Glu 
1               5                   10                  15      


Xaa Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  81
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 

<400>  81

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Trp Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  82
<211>  220
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IMAB362 

<400>  82

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210>  83
<211>  45
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8

<400>  83

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  84
<211>  24
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8Ĥ

<400>  84

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  85
<211>  42
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  4-1BB̼

<400>  85

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  86
<211>  112
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD3 źŴ

<400>  86

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  87
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  T2Aи

<400>  87

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        

<210>  88
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CD8ź

<400>  88

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  89
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  linker

<400>  89

Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  90
<211>  250
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  5E6 scFv

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Arg Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys 
145                 150                 155                 160 


Ser Ser Gln Ser Leu Leu Ala Ser Gly Asn Gln Lys Asn Tyr Leu Thr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp 
            180                 185                 190         


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Val Ala Val Tyr Tyr Cys Gln Asn Val Tyr Ile Tyr Pro Phe Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
                245                 250 


<210>  91
<211>  416
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ori

<400>  91

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys 
            20                  25                  30          


Val Leu Leu Arg Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Glu 
        35                  40                  45              


Pro Pro Thr Cys Ser Pro Gln Gln Phe Thr Cys Phe Thr Gly Glu Ile 
    50                  55                  60                  


Asp Cys Ile Pro Val Ala Trp Arg Cys Asp Gly Phe Thr Glu Cys Glu 
65                  70                  75                  80  


Asp His Ser Asp Glu Leu Asn Cys Pro Val Cys Ser Glu Ser Gln Phe 
                85                  90                  95      


Gln Cys Ala Ser Gly Gln Cys Ile Asp Gly Ala Leu Arg Cys Asn Gly 
            100                 105                 110         


Asp Ala Asn Cys Gln Asp Lys Ser Asp Glu Lys Asn Cys Glu Val Leu 
        115                 120                 125             


Cys Leu Ile Asp Gln Phe Arg Cys Ala Asn Gly Gln Cys Ile Gly Lys 
    130                 135                 140                 


His Lys Lys Cys Asp His Asn Val Asp Cys Ser Asp Lys Ser Asp Glu 
145                 150                 155                 160 


Leu Asp Cys Tyr Pro Thr Glu Glu Pro Ala Pro Gln Ala Thr Asn Thr 
                165                 170                 175     


Val Gly Ser Val Ile Gly Val Ile Val Thr Ile Phe Val Ser Gly Thr 
            180                 185                 190         


Val Tyr Phe Ile Cys Gln Arg Met Leu Cys Pro Arg Met Lys Gly Asp 
        195                 200                 205             


Gly Glu Thr Met Thr Asn Asp Tyr Val Val His Gly Pro Ala Ser Val 
    210                 215                 220                 


Pro Leu Gly Tyr Val Pro His Pro Ser Ser Leu Ser Gly Ser Leu Pro 
225                 230                 235                 240 


Gly Met Ser Arg Gly Lys Ser Met Ile Ser Ser Leu Ser Ile Met Gly 
                245                 250                 255     


Gly Ser Ser Gly Pro Pro Tyr Asp Arg Ala His Val Thr Gly Ala Ser 
            260                 265                 270         


Ser Ser Ser Ser Ser Ser Thr Lys Gly Thr Tyr Phe Pro Ala Ile Leu 
        275                 280                 285             


Asn Pro Pro Pro Ser Pro Ala Thr Glu Arg Ser His Tyr Thr Met Glu 
    290                 295                 300                 


Phe Gly Tyr Ser Ser Asn Ser Pro Ser Thr His Arg Ser Tyr Ser Tyr 
305                 310                 315                 320 


Arg Pro Tyr Ser Tyr Arg His Phe Ala Pro Pro Thr Thr Pro Cys Ser 
                325                 330                 335     


Thr Asp Val Cys Asp Ser Asp Tyr Ala Pro Ser Arg Arg Met Thr Ser 
            340                 345                 350         


Val Ala Thr Ala Lys Gly Tyr Thr Ser Asp Leu Asn Tyr Asp Ser Glu 
        355                 360                 365             


Pro Val Pro Pro Pro Pro Thr Pro Arg Ser Gln Tyr Leu Ser Ala Glu 
    370                 375                 380                 


Glu Asn Tyr Glu Ser Cys Pro Pro Ser Pro Tyr Thr Glu Arg Ser Tyr 
385                 390                 395                 400 


Ser His His Leu Tyr Pro Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser 
                405                 410                 415     


<210>  92
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Standard scFv VH

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ile Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Asn Trp His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile His Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Tyr Asn Gly Asn Ser Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  93
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Standard scFv VL

<400>  93

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ala Tyr Ser Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        