                         б

<110>  պҽҩɷ޹˾
       Ϻҽҩ޹˾
 
<120>  ض̵TACIļںϵ׺;

<130>  722033CPCT

<140>  PCT/CN2022/
<141>  2022-03-31

<150>  202110348497.6
<151>  2021-03-31

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser 
                165 


<210>  2
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-1

<400>  2

Ser Gly Leu Gly Arg Ser Arg Lys Gly Gly Lys Ser Arg Val Asp Gln 
1               5                   10                  15      


Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg Ser 
            20                  25                  30          


Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser 
        35                  40                  45              


Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe 
    50                  55                  60                  


Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His 
65                  70                  75                  80  


Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro 
                85                  90                  95      


Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val Asn 
            100                 105                 110         


Leu Pro Pro Glu Leu Arg Lys Gln Arg Ser Gly Glu Val Glu Gln Asn 
        115                 120                 125             


Ser Asp Asn Ser Gly Lys Tyr Gln Gly Leu Glu His Arg Gly Ser Glu 
    130                 135                 140                 


Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val Ala 
145                 150                 155                 160 


Leu Val Tyr Ser 
                


<210>  3
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-2

<400>  3

Ser Gly Leu Gly Arg Ser Arg Lys Gly Gly Lys Ser Arg Val Asp Gln 
1               5                   10                  15      


Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg Ser 
            20                  25                  30          


Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser 
        35                  40                  45              


Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe 
    50                  55                  60                  


Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His 
65                  70                  75                  80  


Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro 
                85                  90                  95      


Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val Asn 
            100                 105                 110         


Leu Pro Pro Glu Leu Arg Lys Gln Arg Ser Gly Glu Val Glu Asn Asn 
        115                 120                 125             


Ser Asp Asn Ser Gly 
    130             


<210>  4
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-3

<400>  4

Ser Gly Leu Gly Arg Ser Arg Lys Gly Gly Lys Ser Arg Val Asp Gln 
1               5                   10                  15      


Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg Ser 
            20                  25                  30          


Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser 
        35                  40                  45              


Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe 
    50                  55                  60                  


Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His 
65                  70                  75                  80  


Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro 
                85                  90                  95      


Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val Asn 
            100                 105                 110         


Leu Pro Pro Glu Leu Arg Lys Gln Arg Ser Gly Glu Val Glu 
        115                 120                 125     


<210>  5
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-4

<400>  5

Gly Gly Arg Ser Arg Val Asp Gln Glu Glu Arg Phe Pro Gln Gly Leu 
1               5                   10                  15      


Trp Thr Gly Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp 
            20                  25                  30          


Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln 
        35                  40                  45              


Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys 
    50                  55                  60                  


Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys 
65                  70                  75                  80  


Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu 
                85                  90                  95      


Asn Lys Leu Arg Ser Pro Val Asn Leu Pro Pro Glu Leu Arg Lys Gln 
            100                 105                 110         


Arg Ser Gly Glu Val Glu Asn Asn Ser Asp Asn Ser Gly Lys Tyr Gln 
        115                 120                 125             


Gly Leu Glu His Arg Gly Ser Glu Ala Ser Pro Ala Leu Pro Gly Leu 
    130                 135                 140                 


Lys Leu Ser Ala Asp Gln Val Ala Leu Val Tyr Ser 
145                 150                 155     


<210>  6
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-5

<400>  6

Gly Gly Arg Ser Arg Val Asp Gln Glu Glu Arg Phe Pro Gln Gly Leu 
1               5                   10                  15      


Trp Thr Gly Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp 
            20                  25                  30          


Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln 
        35                  40                  45              


Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys 
    50                  55                  60                  


Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys 
65                  70                  75                  80  


Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu 
                85                  90                  95      


Asn Lys Leu Arg Ser Pro Val Asn Leu Pro Pro Glu Leu Arg Lys Gln 
            100                 105                 110         


Arg Ser Gly Glu Val Glu Asn Asn Ser Asp Asn Ser Gly 
        115                 120                 125 


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-6

<400>  7

Gly Gly Arg Ser Arg Val Asp Gln Glu Glu Arg Phe Pro Gln Gly Leu 
1               5                   10                  15      


Trp Thr Gly Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp 
            20                  25                  30          


Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln 
        35                  40                  45              


Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys 
    50                  55                  60                  


Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys 
65                  70                  75                  80  


Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu 
                85                  90                  95      


Asn Lys Leu Arg Ser Pro Val Asn Leu Pro Pro Glu Leu Arg Lys Gln 
            100                 105                 110         


Arg Ser Gly Glu Val Glu 
        115             


<210>  8
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-7

<400>  8

Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg Ser Cys Pro Glu 
1               5                   10                  15      


Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr 
            20                  25                  30          


Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser 
        35                  40                  45              


Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg 
    50                  55                  60                  


Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys 
65                  70                  75                  80  


Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val Asn Leu Pro Pro 
                85                  90                  95      


<210>  9
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-8

<400>  9

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val Asn Leu Pro 
        35                  40                  45              


Pro Glu Leu Arg Lys Gln Arg Ser Gly Glu Val Glu Asn Asn Ser Asp 
    50                  55                  60                  


Asn Ser Gly Lys Tyr Gln Gly Leu Glu His Arg Gly Ser Glu Ala Ser 
65                  70                  75                  80  


Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val Ala Leu Val 
                85                  90                  95      


Tyr Ser 
        


<210>  10
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9

<400>  10

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  11
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
1               5                   10                  15      


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  12
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RCT-18

<400>  12

Ser Arg Val Asp Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly 
1               5                   10                  15      


Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
            20                  25                  30          


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
        35                  40                  45              


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
    50                  55                  60                  


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
65                  70                  75                  80  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
                85                  90                  95      


Arg Ser Pro Val Asn Leu Pro Pro Glu Leu Asp Lys Thr His Thr Cys 
            100                 105                 110         


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
145                 150                 155                 160 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                165                 170                 175     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        195                 200                 205             


Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                245                 250                 255     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            260                 265                 270         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        275                 280                 285             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330             


<210>  13
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-10

<400>  13

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys 
        35                  40  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   TACI-11

<400>  14

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn 
        35                  


<210>  15
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-12

<400>  15

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu 
        35              


<210>  16
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-13

<400>  16

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys 
        35          


<210>  17
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-14

<400>  17

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe 
        35      


<210>  18
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-1

<400>  18

Ser Thr Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  19
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-2

<400>  19

Ser Leu Ser Cys Ser Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  20
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-3

<400>  20

Ser Leu Ser Cys Arg Glu Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  21
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-4

<400>  21

Ser Leu Ser Cys Arg Gln Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  22
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-5

<400>  22

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-6

<400>  23

Ser Arg Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Thr Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  24
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-7

<400>  24

Ser Arg Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Ala Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  25
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-8

<400>  25

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  26
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-9

<400>  26

Ser Arg Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Thr Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Arg Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  27
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-10

<400>  27

Ser Leu Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  28
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-11

<400>  28

Ser Leu Ser Cys Ser Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  29
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-12

<400>  29

Ser Thr Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  30
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-13

<400>  30

Ser Thr Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Tyr Cys Glu Asn Lys Leu 
        35                  40      


<210>  31
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-14

<400>  31

Ser Thr Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Tyr Cys Glu Asn Lys Leu 
        35                  40      


<210>  32
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15

<400>  32

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Lys Leu 
        35                  40      


<210>  33
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15a

<400>  33

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Lys 
        35                  40  


<210>  34
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15b

<400>  34

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn 
        35                  


<210>  35
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   TACI-9-15c

<400>  35

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu 
        35              


<210>  36
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc1ںϵ

<400>  36

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Lys Leu Glu Pro Lys Ser Ser Asp Lys 
        35                  40                  45              


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    50                  55                  60                  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
65                  70                  75                  80  


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                85                  90                  95      


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            100                 105                 110         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        115                 120                 125             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    130                 135                 140                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
145                 150                 155                 160 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                165                 170                 175     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            180                 185                 190         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        195                 200                 205             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    210                 215                 220                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
225                 230                 235                 240 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                245                 250                 255     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            260                 265                 270         


Lys 
    


<210>  37
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc2ںϵ

<400>  37

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Glu Pro Lys Ser Ser Asp Lys Thr His 
        35                  40                  45              


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    50                  55                  60                  


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
65                  70                  75                  80  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                85                  90                  95      


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            100                 105                 110         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        115                 120                 125             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    130                 135                 140                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
145                 150                 155                 160 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                165                 170                 175     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            180                 185                 190         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        195                 200                 205             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    210                 215                 220                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
225                 230                 235                 240 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                245                 250                 255     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265                 270     


<210>  38
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc3ںϵ

<400>  38

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    50                  55                  60                  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
65                  70                  75                  80  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                85                  90                  95      


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            100                 105                 110         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        115                 120                 125             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    130                 135                 140                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
145                 150                 155                 160 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                165                 170                 175     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            180                 185                 190         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        195                 200                 205             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    210                 215                 220                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
225                 230                 235                 240 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                245                 250                 255     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265                 270 


<210>  39
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc4ںϵ

<400>  39

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Ser Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu 
225                 230                 235                 240 


Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys 
                245                 250                 255     


Gly Gln His Pro Lys Gln Cys Ala Ala Phe Cys Glu Asn Lys 
            260                 265                 270 


<210>  40
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc5ںϵ

<400>  40

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265 


<210>  41
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc6ںϵ

<400>  41

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
    50                  55                  60                  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
65                  70                  75                  80  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                85                  90                  95      


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            100                 105                 110         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        115                 120                 125             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    130                 135                 140                 


Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
145                 150                 155                 160 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                165                 170                 175     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            180                 185                 190         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        195                 200                 205             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    210                 215                 220                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
225                 230                 235                 240 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                245                 250                 255     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265                 270 


<210>  42
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc7ںϵ

<400>  42

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
    50                  55                  60                  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
65                  70                  75                  80  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                85                  90                  95      


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            100                 105                 110         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        115                 120                 125             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    130                 135                 140                 


Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
145                 150                 155                 160 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                165                 170                 175     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            180                 185                 190         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        195                 200                 205             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    210                 215                 220                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
225                 230                 235                 240 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                245                 250                 255     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 
            260                 265                 270         


Ser Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu 
        275                 280                 285             


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
    290                 295                 300                 


Gln Cys Ala Ala Phe Cys Glu Gln Lys 
305                 310             


<210>  43
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc8ںϵ

<400>  43

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
    50                  55                  60                  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
65                  70                  75                  80  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                85                  90                  95      


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            100                 105                 110         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        115                 120                 125             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    130                 135                 140                 


Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
145                 150                 155                 160 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                165                 170                 175     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            180                 185                 190         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        195                 200                 205             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    210                 215                 220                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
225                 230                 235                 240 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                245                 250                 255     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 
            260                 265                 270         


Ser Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu 
        275                 280                 285             


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
    290                 295                 300                 


Gln Cys Ala Ala Phe Cys Glu Ser Lys 
305                 310             


<210>  44
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-9-15Fc9ںϵ

<400>  44

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        35                  40                  45              


Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe 
    50                  55                  60                  


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
65                  70                  75                  80  


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                85                  90                  95      


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            100                 105                 110         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        115                 120                 125             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    130                 135                 140                 


Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
145                 150                 155                 160 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                165                 170                 175     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            180                 185                 190         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        195                 200                 205             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    210                 215                 220                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
225                 230                 235                 240 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                245                 250                 255     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 
            260                 265                 270         


Ser Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu 
        275                 280                 285             


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
    290                 295                 300                 


Gln Cys Ala Ala Phe Cys Glu Ser Ser 
305                 310             


<210>  45
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumabɱ

<400>  45

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  46
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumabɱ

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  47
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ser Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  48
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab LCDR1

<400>  49

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab LCDR2

<400>  50

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab LCDR3

<400>  51

Gln Gln Tyr Asn Ile Tyr Pro Tyr Thr 
1               5                   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab HCDR1

<400>  52

Thr Tyr Trp Leu Gly 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab HCDR2

<400>  53

Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ustekinumab HCDR3

<400>  54

Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe 
1               5                   10  


<210>  55
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-Mab1

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Ser Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr 
    450                 455                 460                 


Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln 
465                 470                 475                 480 


His Pro Lys Gln Cys Ala Ala Phe Cys Glu Asn Lys 
                485                 490         


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-Mab1

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  57
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-Mab2

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Gly Gly Gly Ser Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr 
    450                 455                 460                 


Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln 
465                 470                 475                 480 


His Pro Lys Gln Cys Ala Ala Phe Cys Glu Asn Lys 
                485                 490         


<210>  58
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-Mab2

<400>  58

Ser Thr Ser Cys Arg Glu Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Ala Phe Cys Glu Asn Lys Leu Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
    50                  55                  60                  


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
65                  70                  75                  80  


Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
                85                  90                  95      


Glu Lys Ala Pro Lys Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser 
            100                 105                 110         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        115                 120                 125             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    130                 135                 140                 


Gln Gln Tyr Asn Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
145                 150                 155                 160 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
                165                 170                 175     


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
            180                 185                 190         


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
        195                 200                 205             


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
    210                 215                 220                 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
225                 230                 235                 240 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
                245                 250                 255     


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265                 270 


<210>  59
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab

<400>  59

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  60
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab

<400>  60

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  61
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgGFc1

<400>  61

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  62
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgGFc2

<400>  62

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  63
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgGFc3

<400>  63

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
1               5                   10                  15      


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1

<400>  64

Glu Pro Lys Ser Ser 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2

<400>  65

Gly Gly Gly Ser 
1               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3

<400>  66

Gly Gly Gly Gly Ser 
1               5   


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  68
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-16

<400>  68

Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg 
1               5                   10                  15      


Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys 
            20                  25                  30          


Ala Tyr Phe Cys Glu 
        35          


<210>  69
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-17

<400>  69

Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp 
1               5                   10                  15      


Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala 
            20                  25                  30          


Tyr Phe Cys Glu 
        35      


<210>  70
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-18

<400>  70

Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys 
1               5                   10                  15      


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
            20                  25                  30          


Phe Cys Glu 
        35  


<210>  71
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-19

<400>  71

Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile 
1               5                   10                  15      


Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe 
            20                  25                  30          


Cys Glu 
        


<210>  72
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-20

<400>  72

Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser 
1               5                   10                  15      


Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys 
            20                  25                  30          


Glu 
    


<210>  73
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TACI-21

<400>  73

Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys 
1               5                   10                  15      


Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu 
            20                  25                  30          


