                               SEQUENCE LISTING

<110> BLUEROCK THERAPEUTICS LP
 
<120> METHODS FOR OBTAINING INDUCED PLURIPOTENT STEM CELLS

<130> 025450.WO014

<140>
<141>

<150> 63/166,071
<151> 2021-03-25

<160> 15    

<170> PatentIn version 3.5

<210> 1
<211> 233
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210> 2
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Gly His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys Gly Ser Gly Ala Thr Asn Phe 
225                 230                 235                 240 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                245                 250                 


<210> 3
<211> 360
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210> 4
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn Gly Ser Gly Glu Gly Arg Gly Ser 
        355                 360                 365             


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    370                 375                 380 


<210> 5
<211> 413
<212> PRT
<213> Homo sapiens

<400> 5
Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Glu Leu 
            340                 345                 350         


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
        355                 360                 365             


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
    370                 375                 380                 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
385                 390                 395                 400 


Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
                405                 410             


<210> 6
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Pro Met Ala Val Ser Asp Ala Leu Leu Pro Ser Phe Ser Thr Phe Ala 
1               5                   10                  15      


Ser Gly Pro Ala Gly Arg Glu Lys Thr Leu Arg Gln Ala Gly Ala Pro 
            20                  25                  30          


Asn Asn Arg Trp Arg Glu Glu Leu Ser His Met Lys Arg Leu Pro Pro 
        35                  40                  45              


Val Leu Pro Gly Arg Pro Tyr Asp Leu Ala Ala Ala Thr Val Ala Thr 
    50                  55                  60                  


Asp Leu Glu Ser Gly Gly Ala Gly Ala Ala Cys Gly Gly Ser Asn Leu 
65                  70                  75                  80  


Ala Pro Leu Pro Arg Arg Glu Thr Glu Glu Phe Asn Asp Leu Leu Asp 
                85                  90                  95      


Leu Asp Phe Ile Leu Ser Asn Ser Leu Thr His Pro Pro Glu Ser Val 
            100                 105                 110         


Ala Ala Thr Val Ser Ser Ser Ala Ser Ala Ser Ser Ser Ser Ser Pro 
        115                 120                 125             


Ser Ser Ser Gly Pro Ala Ser Ala Pro Ser Thr Cys Ser Phe Thr Tyr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asn Asp Pro Gly Val Ala Pro Gly Gly Thr Gly 
145                 150                 155                 160 


Gly Gly Leu Leu Tyr Gly Arg Glu Ser Ala Pro Pro Pro Thr Ala Pro 
                165                 170                 175     


Phe Asn Leu Ala Asp Ile Asn Asp Val Ser Pro Ser Gly Gly Phe Val 
            180                 185                 190         


Ala Glu Leu Leu Arg Pro Glu Leu Asp Pro Val Tyr Ile Pro Pro Gln 
        195                 200                 205             


Gln Pro Gln Pro Pro Gly Gly Gly Leu Met Gly Lys Phe Val Leu Lys 
    210                 215                 220                 


Ala Ser Leu Ser Ala Pro Gly Ser Glu Tyr Gly Ser Pro Ser Val Ile 
225                 230                 235                 240 


Ser Val Ser Lys Gly Ser Pro Asp Gly Ser His Pro Val Val Val Ala 
                245                 250                 255     


Pro Tyr Asn Gly Gly Pro Pro Arg Thr Cys Pro Lys Ile Lys Gln Glu 
            260                 265                 270         


Ala Val Ser Ser Cys Thr His Leu Gly Ala Gly Pro Pro Leu Ser Asn 
        275                 280                 285             


Gly His Arg Pro Ala Ala His Asp Phe Pro Leu Gly Arg Gln Leu Pro 
    290                 295                 300                 


Ser Arg Thr Thr Pro Thr Leu Gly Leu Glu Glu Val Leu Ser Ser Arg 
305                 310                 315                 320 


Asp Cys His Pro Ala Leu Pro Leu Pro Pro Gly Phe His Pro His Pro 
                325                 330                 335     


Gly Pro Asn Tyr Pro Ser Phe Leu Pro Asp Gln Met Gln Pro Gln Val 
            340                 345                 350         


Pro Pro Leu His Tyr Gln Glu Leu Met Pro Pro Gly Ser Cys Met Pro 
        355                 360                 365             


Glu Glu Pro Lys Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg 
    370                 375                 380                 


Thr Ala Thr His Thr Cys Asp Tyr Ala Gly Cys Gly Lys Thr Tyr Thr 
385                 390                 395                 400 


Lys Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys 
                405                 410                 415     


Pro Tyr His Cys Asp Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser 
            420                 425                 430         


Asp Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe 
        435                 440                 445             


Gln Cys Gln Lys Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala 
    450                 455                 460                 


Leu His Met Lys Arg His Phe Gly Ser Gly Gln Cys Thr Asn Tyr Ala 
465                 470                 475                 480 


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
                485                 490             


<210> 7
<211> 317
<212> PRT
<213> Homo sapiens

<400> 7
Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210> 8
<211> 318
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Pro Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln 
1               5                   10                  15      


Gln Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly 
            20                  25                  30          


Gly Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala 
        35                  40                  45              


Phe Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn 
    50                  55                  60                  


Pro Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp 
65                  70                  75                  80  


Lys Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys 
                85                  90                  95      


Arg Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg 
            100                 105                 110         


Pro Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu 
        115                 120                 125             


Pro Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val 
    130                 135                 140                 


Gly Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser 
145                 150                 155                 160 


Tyr Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln 
                165                 170                 175     


Asp Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala 
            180                 185                 190         


Ala Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr 
        195                 200                 205             


Asn Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr 
    210                 215                 220                 


Ser Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser 
225                 230                 235                 240 


Met Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val 
                245                 250                 255     


Thr Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg 
            260                 265                 270         


Asp Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala 
        275                 280                 285             


Ala Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val 
    290                 295                 300                 


Pro Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315             


<210> 9
<211> 439
<212> PRT
<213> Homo sapiens

<400> 9
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210> 10
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Pro Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp 
1               5                   10                  15      


Tyr Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe 
            20                  25                  30          


Tyr Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu 
        35                  40                  45              


Asp Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro 
    50                  55                  60                  


Ser Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro 
65                  70                  75                  80  


Phe Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr 
                85                  90                  95      


Ala Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val 
            100                 105                 110         


Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn 
        115                 120                 125             


Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys 
    130                 135                 140                 


Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser 
145                 150                 155                 160 


Gly Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser 
                165                 170                 175     


Leu Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro 
            180                 185                 190         


Ser Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser 
        195                 200                 205             


Cys Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu 
    210                 215                 220                 


Leu Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val 
225                 230                 235                 240 


Leu His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu 
                245                 250                 255     


Gln Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln 
            260                 265                 270         


Ala Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His 
        275                 280                 285             


Ser Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser 
    290                 295                 300                 


Thr His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr 
305                 310                 315                 320 


Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln 
                325                 330                 335     


Ile Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu 
            340                 345                 350         


Glu Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg 
        355                 360                 365             


Asn Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu 
    370                 375                 380                 


Leu Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala 
385                 390                 395                 400 


Thr Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser 
                405                 410                 415     


Glu Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu 
            420                 425                 430         


Glu Gln Leu Arg Asn Ser Cys Ala 
        435                 440 


<210> 11
<211> 620
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Glu Ala Arg Thr Ser Leu Ser Ala His Cys Arg Gly Pro Leu 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Asp Leu Asp Leu Pro Gly Arg Ser Leu Ala 
            20                  25                  30          


Thr Pro Ala Pro Ser Cys Tyr Leu Leu Gly Ser Glu Pro Ser Ser Gly 
        35                  40                  45              


Leu Gly Leu Gln Pro Glu Thr His Leu Pro Glu Gly Ser Leu Lys Arg 
    50                  55                  60                  


Cys Cys Val Leu Gly Leu Pro Pro Thr Ser Pro Ala Ser Ser Ser Pro 
65                  70                  75                  80  


Cys Ala Ser Ser Asp Val Thr Ser Ile Ile Arg Ser Ser Gln Thr Ser 
                85                  90                  95      


Leu Val Thr Cys Val Asn Gly Leu Arg Ser Pro Pro Leu Thr Gly Asp 
            100                 105                 110         


Leu Gly Gly Pro Ser Lys Arg Ala Arg Pro Gly Pro Ala Ser Thr Asp 
        115                 120                 125             


Ser His Glu Gly Ser Leu Gln Leu Glu Ala Cys Arg Lys Ala Ser Phe 
    130                 135                 140                 


Leu Lys Gln Glu Pro Ala Asp Glu Phe Ser Glu Leu Phe Gly Pro His 
145                 150                 155                 160 


Gln Gln Gly Leu Pro Pro Pro Tyr Pro Leu Ser Gln Leu Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Gly Gly Leu Gly Leu Gly Leu Ala Gly Arg Val Val Ala 
            180                 185                 190         


Gly Arg Gln Ala Cys Arg Trp Val Asp Cys Cys Ala Ala Tyr Glu Gln 
        195                 200                 205             


Gln Glu Glu Leu Val Arg His Ile Glu Lys Ser His Ile Asp Gln Arg 
    210                 215                 220                 


Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala Gly Cys Val Arg Arg Tyr 
225                 230                 235                 240 


Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu Ile His Met Arg Val His 
                245                 250                 255     


Ser Gly Glu Lys Pro Asn Lys Cys Met Phe Glu Gly Cys Ser Lys Ala 
            260                 265                 270         


Phe Ser Arg Leu Glu Asn Leu Lys Ile His Leu Arg Ser His Thr Gly 
        275                 280                 285             


Glu Lys Pro Tyr Leu Cys Gln His Pro Gly Cys Gln Lys Ala Phe Ser 
    290                 295                 300                 


Asn Ser Ser Asp Arg Ala Lys His Gln Arg Thr His Leu Asp Thr Lys 
305                 310                 315                 320 


Pro Tyr Ala Cys Gln Ile Pro Gly Cys Ser Lys Arg Tyr Thr Asp Pro 
                325                 330                 335     


Ser Ser Leu Arg Lys His Val Lys Ala His Ser Ala Lys Glu Gln Gln 
            340                 345                 350         


Val Arg Lys Lys Leu His Ala Gly Pro Asp Thr Glu Ala Asp Val Leu 
        355                 360                 365             


Thr Glu Cys Leu Val Leu Gln Gln Leu His Thr Ser Thr Gln Leu Ala 
    370                 375                 380                 


Ala Ser Asp Gly Lys Gly Gly Cys Gly Leu Gly Gln Glu Leu Leu Pro 
385                 390                 395                 400 


Gly Val Tyr Pro Gly Ser Ile Thr Pro His Asn Gly Leu Ala Ser Gly 
                405                 410                 415     


Leu Leu Pro Pro Ala His Asp Val Pro Ser Arg His His Pro Leu Asp 
            420                 425                 430         


Ala Thr Thr Ser Ser His His His Leu Ser Pro Leu Pro Met Ala Glu 
        435                 440                 445             


Ser Thr Arg Asp Gly Leu Gly Pro Gly Leu Leu Ser Pro Ile Val Ser 
    450                 455                 460                 


Pro Leu Lys Gly Leu Gly Pro Pro Pro Leu Pro Pro Ser Ser Gln Ser 
465                 470                 475                 480 


His Ser Pro Gly Gly Gln Pro Phe Pro Thr Leu Pro Ser Lys Pro Ser 
                485                 490                 495     


Tyr Pro Pro Phe Gln Ser Pro Pro Pro Pro Pro Leu Pro Ser Pro Gln 
            500                 505                 510         


Gly Tyr Gln Gly Ser Phe His Ser Ile Gln Ser Cys Phe Pro Tyr Gly 
        515                 520                 525             


Asp Cys Tyr Arg Met Ala Glu Pro Ala Ala Gly Gly Asp Gly Leu Val 
    530                 535                 540                 


Gly Glu Thr His Gly Phe Asn Pro Leu Arg Pro Asn Gly Tyr His Ser 
545                 550                 555                 560 


Leu Ser Thr Pro Leu Pro Ala Thr Gly Tyr Glu Ala Leu Ala Glu Ala 
                565                 570                 575     


Ser Cys Pro Thr Ala Leu Pro Gln Gln Pro Ser Glu Asp Val Val Ser 
            580                 585                 590         


Ser Gly Pro Glu Asp Cys Gly Phe Phe Pro Asn Gly Ala Phe Asp His 
        595                 600                 605             


Cys Leu Gly His Ile Pro Ser Ile Tyr Thr Asp Thr 
    610                 615                 620 


<210> 12
<211> 305
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210> 13
<211> 258
<212> PRT
<213> Homo sapiens

<400> 13
Met Arg Ser Phe Asn Gln Val Ser Ser Ala Pro Gly Gly Ala Ser Lys 
1               5                   10                  15      


Gly Gly Gly Glu Glu Pro Gly Lys Leu Pro Glu Pro Ala Glu Glu Glu 
            20                  25                  30          


Ser Gln Val Leu Arg Gly Thr Gly His Cys Lys Trp Phe Asn Val Arg 
        35                  40                  45              


Met Gly Phe Gly Phe Ile Ser Met Ile Asn Arg Glu Gly Ser Pro Leu 
    50                  55                  60                  


Asp Ile Pro Val Asp Val Phe Val His Gln Ser Lys Leu Phe Met Glu 
65                  70                  75                  80  


Gly Phe Arg Ser Leu Lys Glu Gly Glu Pro Val Glu Phe Thr Phe Lys 
                85                  90                  95      


Lys Ser Ser Lys Gly Leu Glu Ser Ile Arg Val Thr Gly Pro Gly Gly 
            100                 105                 110         


Ser Pro Cys Leu Gly Ser Glu Arg Arg Pro Lys Gly Lys Thr Leu Gln 
        115                 120                 125             


Lys Arg Lys Pro Lys Gly Asp Arg Cys Tyr Asn Cys Gly Gly Leu Asp 
    130                 135                 140                 


His His Ala Lys Glu Cys Ser Leu Pro Pro Gln Pro Lys Lys Cys His 
145                 150                 155                 160 


Tyr Cys Gln Ser Ile Met His Met Val Ala Asn Cys Pro His Lys Asn 
                165                 170                 175     


Val Ala Gln Pro Pro Ala Ser Ser Gln Gly Arg Gln Glu Ala Glu Ser 
            180                 185                 190         


Gln Pro Cys Thr Ser Thr Leu Pro Arg Glu Val Gly Gly Gly His Gly 
        195                 200                 205             


Cys Thr Ser Pro Pro Phe Pro Gln Glu Ala Arg Ala Glu Ile Ser Glu 
    210                 215                 220                 


Arg Ser Gly Arg Ser Pro Gln Glu Ala Ser Ser Thr Lys Ser Ser Ile 
225                 230                 235                 240 


Ala Pro Glu Glu Gln Ser Lys Lys Gly Pro Ser Val Gln Lys Arg Lys 
                245                 250                 255     


Lys Thr 
        


<210> 14
<211> 7675
<212> DNA
<213> Venezuelan equine encephalitis virus

<400> 14
gaaagttcac gttgacatcg aggaagacag cccattcctc agagctttgc agcggagctt       60

cccgcagttt gaggtagaag ccaagcaggt cactgataat gaccatgcta atgccagagc      120

gttttcgcat ctggcttcaa aactgatcga aacggaggtg gacccatccg acacgatcct      180

tgacattgga agtgcgcccg cccgcagaat gtattctaag cacaagtatc attgtatctg      240

tccgatgaga tgtgcggaag atccggacag attgtataag tatgcaacta agctgaagaa      300

aaactgtaag gaaataactg ataaggaatt ggacaagaaa atgaaggagc tcgccgccgt      360

catgagcgac cctgacctgg aaactgagac tatgtgcctc cacgacgacg agtcgtgtcg      420

ctacgaaggg caagtcgctg tttaccagga tgtatacgcg gttgacggac cgacaagtct      480

ctatcaccaa gccaataagg gagttagagt cgcctactgg ataggctttg acaccacccc      540

ttttatgttt aagaacttgg ctggagcata tccatcatac tctaccaact gggccgacga      600

aaccgtgtta acggctcgta acataggcct atgcagctct gacgttatgg agcggtcacg      660

tagagggatg tccattctta gaaagaagta tttgaaacca tccaacaatg ttctattctc      720

tgttggctcg accatctacc acgagaagag ggacttactg aggagctggc acctgccgtc      780

tgtatttcac ttacgtggca agcaaaatta cacatgtcgg tgtgagacta tagttagttg      840

cgacgggtac gtcgttaaaa gaatagctat cagtccaggc ctgtatggga agccttcagg      900

ctatgctgct acgatgcacc gcgagggatt cttgtgctgc aaagtgacag acacattgaa      960

cggggagagg gtctcttttc ccgtgtgcac gtatgtgcca gctacattgt gtgaccaaat     1020

gactggcata ctggcaacag atgtcagtgc ggacgacgcg caaaaactgc tggttgggct     1080

caaccagcgt atagtcgtca acggtcgcac ccagagaaac accaatacca tgaaaaatta     1140

ccttttgccc gtagtggccc aggcatttgc taggtgggca aaggaatata aggaagatca     1200

agaagatgaa aggccactag gactacgaga tagacagtta gtcatggggt gttgttgggc     1260

ttttagaagg cacaagataa catctattta taagcgcccg gatacccaaa ccatcatcaa     1320

agtgaacagc gatttccact cattcgtgct gcccaggata ggcagtaaca cattggagat     1380

cgggctgaga acaagaatca ggaaaatgtt agaggagcac aaggagccgt cacctctcat     1440

taccgccgag gacgtacaag aagctaagtg cgcagccgat gaggctaagg aggtgcgtga     1500

agccgaggag ttgcgcgcag ctctaccacc tttggcagct gatgttgagg agcccactct     1560

ggaagccgat gtcgacttga tgttacaaga ggctggggcc ggctcagtgg agacacctcg     1620

tggcttgata aaggttacca gctacgctgg cgaggacaag atcggctctt acgctgtgct     1680

ttctccgcag gctgtactca agagtgaaaa attatcttgc atccaccctc tcgctgaaca     1740

agtcatagtg ataacacact ctggccgaaa agggcgttat gccgtggaac cataccatgg     1800

taaagtagtg gtgccagagg gacatgcaat acccgtccag gactttcaag ctctgagtga     1860

aagtgccacc attgtgtaca acgaacgtga gttcgtaaac aggtacctgc accatattgc     1920

cacacatgga ggagcgctga acactgatga agaatattac aaaactgtca agcccagcga     1980

gcacgacggc gaatacctgt acgacatcga caggaaacag tgcgtcaaga aagaactagt     2040

cactgggcta gggctcacag gcgagctggt ggatcctccc ttccatgaat tcgcctacga     2100

gagtctgaga acacgaccag ccgctcctta ccaagtacca accatagggg tgtatggcgt     2160

gccaggatca ggcaagtctg gcatcattaa aagcgcagtc accaaaaaag atctagtggt     2220

gagcgccaag aaagaaaact gtgcagaaat tataagggac gtcaagaaaa tgaaagggct     2280

ggacgtcaat gccagaactg tggactcagt gctcttgaat ggatgcaaac accccgtaga     2340

gaccctgtat attgacgaag cttttgcttg tcatgcaggt actctcagag cgctcatagc     2400

cattataaga cctaaaaagg cagtgctctg cggggatccc aaacagtgcg gtttttttaa     2460

catgatgtgc ctgaaagtgc attttaacca cgagatttgc acacaagtct tccacaaaag     2520

catctctcgc cgttgcacta aatctgtgac ttcggtcgtc tcaaccttgt tttacgacaa     2580

aaaaatgaga acgacgaatc cgaaagagac taagattgtg attgacacta ccggcagtac     2640

caaacctaag caggacgatc tcattctcac ttgtttcaga gggtgggtga agcagttgca     2700

aatagattac aaaggcaacg aaataatgac ggcagctgcc tctcaagggc tgacccgtaa     2760

aggtgtgtat gccgttcggt acaaggtgaa tgaaaatcct ctgtacgcac ccacctcaga     2820

acatgtgaac gtcctactga cccgcacgga ggaccgcatc gtgtggaaaa cactagccgg     2880

cgacccatgg ataaaaacac tgactgccaa gtaccctggg aatttcactg ccacgataga     2940

ggagtggcaa gcagagcatg atgccatcat gaggcacatc ttggagagac cggaccctac     3000

cgacgtcttc cagaataagg caaacgtgtg ttgggccaag gctttagtgc cggtgctgaa     3060

gaccgctggc atagacatga ccactgaaca atggaacact gtggattatt ttgaaacgga     3120

caaagctcac tcagcagaga tagtattgaa ccaactatgc gtgaggttct ttggactcga     3180

tctggactcc ggtctatttt ctgcacccac tgttccgtta tccattagga ataatcactg     3240

ggataactcc ccgtcgccta acatgtacgg gctgaataaa gaagtggtcc gtcagctctc     3300

tcgcaggtac ccacaactgc ctcgggcagt tgccactgga agagtctatg acatgaacac     3360

tggtacactg cgcaattatg atccgcgcat aaacctagta cctgtaaaca gaagactgcc     3420

tcatgcttta gtcctccacc ataatgaaca cccacagagt gacttttctt cattcgtcag     3480

caaattgaag ggcagaactg tcctggtggt cggggaaaag ttgtccgtcc caggcaaaat     3540

ggttgactgg ttgtcagacc ggcctgaggc taccttcaga gctcggctgg atttaggcat     3600

cccaggtgat gtgcccaaat atgacataat atttgttaat gtgaggaccc catataaata     3660

ccatcactat cagcagtgtg aagaccatgc cattaagctt agcatgttga ccaagaaagc     3720

ttgtctgcat ctgaatcccg gcggaacctg tgtcagcata ggttatggtt acgctgacag     3780

ggccagcgaa agcatcattg gtgctatagc gcggcagttc aagttttccc gggtatgcaa     3840

accgaaatcc tcacttgaag agacggaagt tctgtttgta ttcattgggt acgatcgcaa     3900

ggcccgtacg cacaatcctt acaagctttc atcaaccttg accaacattt atacaggttc     3960

cagactccac gaagccggat gtgcaccctc atatcatgtg gtgcgagggg atattgccac     4020

ggccaccgaa ggagtgatta taaatgctgc taacagcaaa ggacaacctg gcggaggggt     4080

gtgcggagcg ctgtataaga aattcccgga aagcttcgat ttacagccga tcgaagtagg     4140

aaaagcgcga ctggtcaaag gtgcagctaa acatatcatt catgccgtag gaccaaactt     4200

caacaaagtt tcggaggttg aaggtgacaa acagttggca gaggcttatg agtccatcgc     4260

taagattgtc aacgataaca attacaagtc agtagcgatt ccactgttgt ccaccggcat     4320

cttttccggg aacaaagatc gactaaccca atcattgaac catttgctga cagctttaga     4380

caccactgat gcagatgtag ccatatactg cagggacaag aaatgggaaa tgactctcaa     4440

ggaagcagtg gctaggagag aagcagtgga ggagatatgc atatccgacg actcttcagt     4500

gacagaacct gatgcagagc tggtgagggt gcatccgaag agttctttgg ctggaaggaa     4560

gggctacagc acaagcgatg gcaaaacttt ctcatatttg gaagggacca agtttcacca     4620

ggcggccaag gatatagcag aaattaatgc catgtggccc gttgcaacgg aggccaatga     4680

gcaggtatgc atgtatatcc tcggagaaag catgagcagt attaggtcga aatgccccgt     4740

cgaagagtcg gaagcctcca caccacctag cacgctgcct tgcttgtgca tccatgccat     4800

gactccagaa agagtacagc gcctaaaagc ctcacgtcca gaacaaatta ctgtgtgctc     4860

atcctttcca ttgccgaagt atagaatcac tggtgtgcag aagatccaat gctcccagcc     4920

tatattgttc tcaccgaaag tgcctgcgta tattcatcca aggaagtatc tcgtggaaac     4980

accaccggta gacgagactc cggagccatc ggcagagaac caatccacag aggggacacc     5040

tgaacaacca ccacttataa ccgaggatga gaccaggact agaacgcctg agccgatcat     5100

catcgaagag gaagaagagg atagcataag tttgctgtca gatggcccga cccaccaggt     5160

gctgcaagtc gaggcagaca ttcacgggcc gccctctgta tctagctcat cctggtccat     5220

tcctcatgca tccgactttg atgtggacag tttatccata cttgacaccc tggagggagc     5280

tagcgtgacc agcggggcaa cgtcagccga gactaactct tacttcgcaa agagtatgga     5340

gtttctggcg cgaccggtgc ctgcgcctcg aacagtattc aggaaccctc cacatcccgc     5400

tccgcgcaca agaacaccgt cacttgcacc cagcagggcc tgctcgagaa ccagcctagt     5460

ttccaccccg ccaggcgtga atagggtgat cactagagag gagctcgagg cgcttacccc     5520

gtcacgcact cctagcaggt cggtctcgag aaccagcctg gtctccaacc cgccaggcgt     5580

aaatagggtg attacaagag aggagtttga ggcgttcgta gcacaacaac aatgacggtt     5640

tgatgcgggt gcatacatct tttcctccga caccggtcaa gggcatttac aacaaaaatc     5700

agtaaggcaa acggtgctat ccgaagtggt gttggagagg accgaattgg agatttcgta     5760

tgccccgcgc ctcgaccaag aaaaagaaga attactacgc aagaaattac agttaaatcc     5820

cacacctgct aacagaagca gataccagtc caggaaggtg gagaacatga aagccataac     5880

agctagacgt attctgcaag gcctagggca ttatttgaag gcagaaggaa aagtggagtg     5940

ctaccgaacc ctgcatcctg ttcctttgta ttcatctagt gtgaaccgtg ccttttcaag     6000

ccccaaggtc gcagtggaag cctgtaacgc catgttgaaa gagaactttc cgactgtggc     6060

ttcttactgt attattccag agtacgatgc ctatttggac atggttgacg gagcttcatg     6120

ctgcttagac actgccagtt tttgccctgc aaagctgcgc agctttccaa agaaacactc     6180

ctatttggaa cccacaatac gatcggcagt gccttcagcg atccagaaca cgctccagaa     6240

cgtcctggca gctgccacaa aaagaaattg caatgtcacg caaatgagag aattgcccgt     6300

attggattcg gcggccttta atgtggaatg cttcaagaaa tatgcgtgta ataatgaata     6360

ttgggaaacg tttaaagaaa accccatcag gcttactgaa gaaaacgtgg taaattacat     6420

taccaaatta aaaggaccaa aagctgctgc tctttttgcg aagacacata atttgaatat     6480

gttgcaggac ataccaatgg acaggtttgt aatggactta aagagagacg tgaaagtgac     6540

tccaggaaca aaacatactg aagaacggcc caaggtacag gtgatccagg ctgccgatcc     6600

gctagcaaca gcgtatctgt gcggaatcca ccgagagctg gttaggagat taaatgcggt     6660

cctgcttccg aacattcata cactgtttga tatgtcggct gaagactttg acgctattat     6720

agccgagcac ttccagcctg gggattgtgt tctggaaact gacatcgcgt cgtttgataa     6780

aagtgaggac gacgccatgg ctctgaccgc gttaatgatt ctggaagact taggtgtgga     6840

cgcagagctg ttgacgctga ttgaggcggc tttcggcgaa atttcatcaa tacatttgcc     6900

cactaaaact aaatttaaat tcggagccat gatgaaatct ggaatgttcc tcacactgtt     6960

tgtgaacaca gtcattaaca ttgtaatcgc aagcagagtg ttgagagaac ggctaaccgg     7020

atcaccatgt gcagcattca ttggagatga caatatcgtg aaaggagtca aatcggacaa     7080

attaatggca gacaggtgcg ccacctggtt gaatatggaa gtcaagatta tagatgctgt     7140

ggtgggcgag aaagcgcctt atttctgtgg agggtttatt ttgtgtgact ccgtgaccgg     7200

cacagcgtgc cgtgtggcag accccctaaa aaggctgttt aagcttggca aacctctggc     7260

agcagacgat gaacatgatg atgacaggag aagggcattg catgaagagt caacacgctg     7320

gaaccgagtg ggtattcttt cagagctgtg caaggcagta gaatcaaggt atgaaaccgt     7380

aggaacttcc atcatagtta tggccatgac tactctagct agcagtgtta aatcattcag     7440

ctacctgaga ggggccccta taactctcta cggctaacct gaatggacta cgacatagtc     7500

tagtccgcca agtctagcat atgggcgcgt gaattcgccg cgaattggca agctgcttac     7560

atagaactcg cggcgattgg catgccgcct taaaattttt attttatttt tcttttcttt     7620

tccgaatcgg attttgtttt taatatttca aaaaaaaaaa aaaaaaaaaa aaaaa          7675


<210> 15
<211> 7675
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
gaaagttcac gttgacatcg aggaagacag cccattcctc agagctttgc agcggagctt       60

cccgcagttt gaggtagaag ccaagcaggt cactgataat gaccatgcta atgccagagc      120

gttttcgcat ctggcttcaa aactgatcga aacggaggtg gacccatccg acacgatcct      180

tgacattgga agtgcgcccg cccgcagaat gtattctaag cacaagtatc attgtatctg      240

tccgatgaga tgtgcggaag atccggacag attgtataag tatgcaacta agctgaagaa      300

aaactgtaag gaaataactg ataaggaatt ggacaagaaa atgaaggagc tggccgccgt      360

catgagcgac cctgacctgg aaactgagac tatgtgcctc cacgacgacg agtcgtgtcg      420

ctacgaaggg caagtcgctg tttaccagga tgtatacgcg gttgacggac cgacaagtct      480

ctatcaccaa gccaataagg gagttagagt cgcctactgg ataggctttg acaccacccc      540

ttttatgttt aagaacttgg ctggagcata tccatcatac tctaccaact gggccgacga      600

aaccgtgtta acggctcgta acataggcct atgcagctct gacgttatgg agcggtcacg      660

tagagggatg tccattctta gaaagaagta tttgaaacca tccaacaatg ttctattctc      720

tgttggctcg accatctacc acgagaagag ggacttactg aggagctggc acctgccgtc      780

tgtatttcac ttacgtggca agcaaaatta cacatgtcgg tgtgagacta tagttagttg      840

cgacgggtac gtcgttaaaa gaatagctat cagtccaggc ctgtatggga agccttcagg      900

ctatgctgct acgatgcacc gcgagggatt cttgtgctgc aaagtgacag acacattgaa      960

cggggagagg gtctcttttc ccgtgtgcac gtatgtgcca gctacattgt gtgaccaaat     1020

gactggcata ctggcaacag atgtcagtgc ggacgacgcg caaaaactgc tggttgggct     1080

caaccagcgt atagtcgtca acggtcgcac ccagagaaac accaatacca tgaaaaatta     1140

ccttttgccc gtagtggccc aggcatttgc taggtgggca aaggaatata aggaagatca     1200

agaagatgaa aggccactag gactacgaga tagacagtta gtcatggggt gttgttgggc     1260

ttttagaagg cacaagataa catctattta taagcgcccg gatacccaaa ccatcatcaa     1320

agtgaacagc gatttccact cattcgtgct gcccaggata ggcagtaaca cattggagat     1380

cgggctgaga acaagaatca ggaaaatgtt agaggagcac aaggagccgt cacctctcat     1440

taccgccgag gacgtacaag aagctaagtg cgcagccgat gaggctaagg aggtgcgtga     1500

agccgaggag ttgcgcgcag ctctaccacc tttggcagct gatgttgagg agcccactct     1560

ggaggcagac gtcgacttga tgttacaaga ggctggggcc ggctcagtgg agacacctcg     1620

tggcttgata aaggttacca gctacgatgg cgaggacaag atcggctctt acgctgtgct     1680

ttctccgcag gctgtactca agagtgaaaa attatcttgc atccaccctc tcgctgaaca     1740

agtcatagtg ataacacact ctggccgaaa agggcgttat gccgtggaac cataccatgg     1800

taaagtagtg gtgccagagg gacatgcaat acccgtccag gactttcaag ctctgagtga     1860

aagtgccacc attgtgtaca acgaacgtga gttcgtaaac aggtacctgc accatattgc     1920

cacacatgga ggagcgctga acactgatga agaatattac aaaactgtca agcccagcga     1980

gcacgacggc gaatacctgt acgacatcga caggaaacag tgcgtcaaga aagaactagt     2040

cactgggcta gggctcacag gcgagctggt ggatcctccc ttccatgaat tcgcctacga     2100

gagtctgaga acacgaccag ccgctcctta ccaagtacca accatagggg tgtatggcgt     2160

gccaggatca ggcaagtctg gcatcattaa aagcgcagtc accaaaaaag atctagtggt     2220

gagcgccaag aaagaaaact gtgcagaaat tataagggac gtcaagaaaa tgaaagggct     2280

ggacgtcaat gccagaactg tggactcagt gctcttgaat ggatgcaaac accccgtaga     2340

gaccctgtat attgacgaag cttttgcttg tcatgcaggt actctcagag cgctcatagc     2400

cattataaga cctaaaaagg cagtgctctg cggggatccc aaacagtgcg gtttttttaa     2460

catgatgtgc ctgaaagtgc attttaacca cgagatttgc acacaagtct tccacaaaag     2520

catctctcgc cgttgcacta aatctgtgac ttcggtcgtc tcaaccttgt tttacgacaa     2580

aaaaatgaga acgacgaatc cgaaagagac taagattgtg attgacacta ccggcagtac     2640

caaacctaag caggacgatc tcattctcac ttgtttcaga gggtgggtga agcagttgca     2700

aatagattac aaaggcaacg aaataatgac ggcagctgcc tctcaagggc tgacccgtaa     2760

aggtgtgtat gccgttcggt acaaggtgaa tgaaaatcct ctgtacgcac ccacctcaga     2820

acatgtgaac gtcctactga cccgcacgga ggaccgcatc gtgtggaaaa cactagccgg     2880

cgacccatgg ataaaaacac tgactgccaa gtaccctggg aatttcactg ccacgataga     2940

ggagtggcaa gcagagcatg atgccatcat gaggcacatc ttggagagac cggaccctac     3000

cgacgtcttc cagaataagg caaacgtgtg ttgggccaag gctttagtgc cggtgctgaa     3060

gaccgctggc atagacatga ccactgaaca atggaacact gtggattatt ttgaaacgga     3120

caaagctcac tcagcagaga tagtattgaa ccaactatgc gtgaggttct ttggactcga     3180

tctggactcc ggtctatttt ctgcacccac tgttccgtta tccattagga ataatcactg     3240

ggataactcc ccgtcgccta acatgtacgg gctgaataaa gaagtggtcc gtcagctctc     3300

tcgcaggtac ccacaactgc ctcgggcagt tgccactgga agagtctatg acatgaacac     3360

tggtacactg cgcaattatg atccgcgcat aaacctagta cctgtaaaca gaagactgcc     3420

tcatgcttta gtcctccacc ataatgaaca cccacagagt gacttttctt cattcgtcag     3480

caaattgaag ggcagaactg tcctggtggt cggggaaaag ttgtccgtcc caggcaaaat     3540

ggttgactgg ttgtcagacc ggcctgaggc taccttcaga gctcggctgg atttaggcat     3600

cccaggtgat gtgcccaaat atgacataat atttgttaat gtgaggaccc catataaata     3660

ccatcactat cagcagtgtg aagaccatgc cattaagctt agcatgttga ccaagaaagc     3720

ttgtctgcat ctgaatcccg gcggaacctg tgtcagcata ggttatggtt acgctgacag     3780

ggccagcgaa agcatcattg gtgctatagc gcggcagttc aagttttccc gggtatgcaa     3840

accgaaatcc tcacttgaag agacggaagt tctgtttgta ttcattgggt acgatcgcaa     3900

ggcccgtacg cacaattctt acaagctttc atcaaccttg accaacattt atacaggttc     3960

cagactccac gaagccggat gtgcaccctc atatcatgtg gtgcgagggg atattgccac     4020

ggccaccgaa ggagtgatta taaatgctgc taacagcaaa ggacaacctg gcggaggggt     4080

gtgcggagcg ctgtataaga aattcccgga aagcttcgat ttacagccga tcgaagtagg     4140

aaaagcgcga ctggtcaaag gtgcagctaa acatatcatt catgccgtag gaccaaactt     4200

caacaaagtt tcggaggttg aaggtgacaa acagttggca gaggcttatg agtccatcgc     4260

taagattgtc aacgataaca attacaagtc agtagcgatt ccactgttgt ccaccggcat     4320

cttttccggg aacaaagatc gactaaccca atcattgaac catttgctga cagctttaga     4380

caccactgat gcagatgtag ccatatactg cagggacaag aaatgggaaa tgactctcaa     4440

ggaagcagtg gctaggagag aagcagtgga ggagatatgc atatccgacg actcttcagt     4500

gacagaacct gatgcagagc tggtgagggt gcatccgaag agttctttgg ctggaaggaa     4560

gggctacagc acaagcgatg gcaaaacttt ctcatatttg gaagggacca agtttcacca     4620

ggcggccaag gatatagcag aaattaatgc catgtggccc gttgcaacgg aggccaatga     4680

gcaggtatgc atgtatatcc tcggagaaag catgagcagt attaggtcga aatgccccgt     4740

cgaagagtcg gaagcctcca caccacctag cacgctgcct tgcttgtgca tccatgccat     4800

gactccagaa agagtacagc gcctaaaagc ctcacgtcca gaacaaatta ctgtgtgctc     4860

atcctttcca ttgccgaagt atagaatcac tggtgtgcag aagatccaat gctcccagcc     4920

tatattgttc tcaccgaaag tgcctgcgta tattcatcca aggaagtatc tcgtggaaac     4980

accaccggta gacgagactc cggagccatc ggcagagaac caatccacag aggggacacc     5040

tgaacaacca ccacttataa ccgaggatga gaccaggact agaacgcctg agccgatcat     5100

catcgaagag gaagaagagg atagcataag tttgctgtca gatggcccga cccaccaggt     5160

gctgcaagtc gaggcagaca ttcacgggcc gccctctgta tctagctcat cctggtccat     5220

tcctcatgca tccgactttg atgtggacag tttatccata cttgacaccc tggagggagc     5280

tagcgtgacc agcggggcaa cgtcagccga gactaactct tacttcgcaa agagtatgga     5340

gtttctggcg cgaccggtgc ctgcgcctcg aacagtattc aggaaccctc cacatcccgc     5400

tccgcgcaca agaacaccgt cacttgcacc cagcagggcc tgctcgagaa ccagcctagt     5460

ttccaccccg ccaggcgtga atagggtgat cactagagag gagctcgagg cgcttacccc     5520

gtcacgcact cctagcaggt cggtctcgag aaccagcctg gtctccaacc cgccaggcgt     5580

aaatagggtg attacaagag aggagtttga ggcgttcgta gcacaacaac aatgacggtt     5640

tgatgcgggt gcatacatct tttcctccga caccggtcaa gggcatttac aacaaaaatc     5700

agtaaggcaa acggtgctat ccgaagtggt gttggagagg accgaattgg agatttcgta     5760

tgccccgcgc ctcgaccaag aaaaagaaga attactacgc aagaaattac agttaaatcc     5820

cacacctgct aacagaagca gataccagtc caggaaggtg gagaacatga aagccataac     5880

agctagacgt attctgcaag gcctagggca ttatttgaag gcagaaggaa aagtggagtg     5940

ctaccgaacc ctgcatcctg ttcctttgta ttcatctagt gtgaaccgtg ccttttcaag     6000

ccccaaggtc gcagtggaag cctgtaacgc catgttgaaa gagaactttc cgactgtggc     6060

ttcttactgt attattccag agtacgatgc ctatttggac atggttgacg gagcttcatg     6120

ctgcttagac actgccagtt tttgccctgc aaagctgcgc agctttccaa agaaacactc     6180

ctatttggaa cccacaatac gatcggcagt gccttcagcg atccagaaca cgctccagaa     6240

cgtcctggca gctgccacaa aaagaaattg caatgtcacg caaatgagag aattgcccgt     6300

attggattcg gcggccttta atgtggaatg cttcaagaaa tatgcgtgta ataatgaata     6360

ttgggaaacg tttaaagaaa accccatcag gcttactgaa gaaaacgtgg taaattacat     6420

taccaaatta aaaggaccaa aagctgctgc tctttttgcg aagacacata atttgaatat     6480

gttgcaggac ataccaatgg acaggtttgt aatggactta aagagagacg tgaaagtgac     6540

tccaggaaca aaacatactg aagaacggcc caaggtacag gtgatccagg ctgccgatcc     6600

gctagcaaca gcgtatctgt gcggaatcca ccgagagctg gttaggagat taaatgcggt     6660

cctgcttccg aacattcata cactgtttga tatgtcggct gaagactttg acgctattat     6720

agccgagcac ttccagcctg gggattgtgt tctggaaact gacatcgcgt cgtttgataa     6780

aagtgaggac gacgccatgg ctctgaccgc gttaatgatt ctggaagact taggtgtgga     6840

cgcagagctg ttgacgctga ttgaggcggc tttcggcgaa atttcatcaa tacatttgcc     6900

cactaaaact aaatttaaat tcggagccat gatgaaatct ggaatgttcc tcacactgtt     6960

tgtgaacaca gtcattaaca ttgtaatcgc aagcagagtg ttgagagaac ggctaaccgg     7020

atcaccatgt gcagcattca ttggagatga caatatcgtg aaaggagtca aatcggacaa     7080

attaatggca gacaggtgcg ccacctggtt gaatatggaa gtcaagatta tagatgctgt     7140

ggtgggcgag aaagcgcctt atttctgtgg agggtttatt ttgtgtgact ccgtgaccgg     7200

cacagcgtgc cgtgtggcag accccctaaa aaggctgttt aagcttggca aacctctggc     7260

agcagacgat gaacatgatg atgacaggag aagggcattg catgaagagt caacacgctg     7320

gaaccgagtg ggtattcttt cagagctgtg caaggcagta gaatcaaggt atgaaaccgt     7380

aggaacttcc atcatagtta tggccatgac tactctagct agcagtgtta aatcattcag     7440

ctacctgaga ggggccccta taactctcta cggctaacct gaatggacta cgacatagtc     7500

tagtccgcca agtctagcat atgggcgcgt gaattcgccg cgaattggca agctgcttac     7560

atagaactcg cggcgattgg catgccgcct taaaattttt attttatttt tcttttcttt     7620

tccgaatcgg attttgtttt taatatttca aaaaaaaaaa aaaaaaaaaa aaaaa          7675


