                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Johnson, Lexus R
       Minn, Andy J
       June, Carl H
 
<120>  CAR-T DELIVERY OF SYNTHETIC PEPTIDE THERAPEUTICS

<130>  046483-7321WO1(02830)

<150>  63/166,073
<151>  2021-03-25

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  1

Cys Ile Phe Glu Phe Pro Gly Cys 
1               5               


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  2

Ile Phe Glu Phe Pro Gly 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  3

Leu Phe Ile Leu Ser Gly 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  4

Thr Phe Glu Tyr Ser Gly 
1               5       


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  5

Met Phe Glu Tyr Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  6

Leu Phe Ile Lys Pro 
1               5   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  7

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  8

Ala Val Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ile Pro Val Ala 
            20              


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  9

Ala Val Pro Ile 
1               


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  10

Ala Val Pro Ile Gly Gly Gly Gly Gly Ile Pro Val Ala 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  11

Ala Val Pro Ile Gly Gly Gly Gly Gly Ala Val Pro Ile 
1               5                   10              


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  12

Ala Val Pro Ile Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ile Pro 
1               5                   10                  15      


Val Ala 
        


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  13

Ala Pro Leu Pro Pro 
1               5   


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  14

Cys Ala Pro Leu Pro Pro Cys 
1               5           


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  15

Ala Pro Leu Gly Gly 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  16

Val Pro His Pro Pro 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  17

Gly Ser Gly Gly Ser 
1               5   


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  repeat n times, where n represents an integer of at least 1

<400>  18

Gly Gly Gly Ser 
1               


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  19

Gly Gly Gly Gly Ser 
1               5   


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Gly Gly Ser Gly 
1               


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  21

Gly Gly Ser Gly Gly 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  22

Gly Ser Gly Ser Gly 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  23

Gly Ser Gly Gly Gly 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  24

Gly Gly Gly Ser Gly 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  25

Gly Ser Ser Ser Gly 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  26

Gly Gly Gly Gly Ser 
1               5   


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  27

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  28
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  28
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  29

Asp Lys Thr His Thr 
1               5   


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  30

Cys Pro Pro Cys 
1               


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  31

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  32

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  33

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  34

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  35

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  36

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  37

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  38

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  39

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  40

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  41
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv

<400>  41

Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu 
145                 150                 155                 160 


Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val 
                165                 170                 175     


Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val 
            180                 185                 190         


Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg 
        195                 200                 205             


Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met 
    210                 215                 220                 


Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His 
225                 230                 235                 240 


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser 
            260         


<210>  42
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-mesothelin scFv

<400>  42

Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr 
65                  70                  75                  80  


Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile 
        195                 200                 205             


Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr 
                245                 250                 255     


Lys Val Glu Ile Lys 
            260     


<210>  43
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-Her2 scFv

<400>  43

Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val 
1               5                   10                  15      


Ile Met Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Val Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


