                         SEQUENCE LISTING

<110>  ONCXERNA THERAPEUTICS, INC.
 
<120>  TARGETED THERAPIES IN COLORECTAL CANCER 

<130>  4488.024PC01

<150>  US 63/166,167
<151>  2021-03-25  

<150>  US 63/188,321
<151>  2021-05-13

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH CDR1

<400>  1

Gly Tyr Asn Met Asn 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  2

His Ile Asp Pro Tyr Tyr Gly 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  3

Tyr Cys Val Lys Gly Gly Tyr Tyr 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  4

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  5

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  6

Leu Gln Tyr Val Ser Ser Pro Pro Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  7

Ser Tyr Ala Ile Ser 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  8

Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  9

Gly Arg Ser Met Val Arg Gly Val Ile Ile Pro Phe Asn Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  10

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  11

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  12

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF VH CDR1

<400>  13

Asn Tyr Trp Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF VH CDR2

<400>  14

Asp Ile Asn Pro Ser Asn Gly Arg Thr Ser Tyr Lys Glu Lys Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEGF VH CDR3

<400>  15

His Tyr Asp Asp Lys Tyr Tyr Pro Leu Met Asp Tyr 
1               5                   10          


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL4 VH CDR1

<400>  16

Thr Ala Tyr Tyr Ile His 
1               5       


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL4 VH CDR2

<400>  17

Tyr Ile Ser Asn Tyr Asn Arg Ala Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLL4 V4 CDR3

<400>  18

Arg Asp Tyr Asp Tyr Asp Val Gly Met Asp Tyr 
1               5                   10      


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  19

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Lys 
1               5                   10                  15  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  20

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  21

Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gly 
1               5                   10          


<210>  22
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asp Pro Tyr Tyr Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Tyr Tyr Gly His Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Gly Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Val Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  24
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Asn Tyr Asn Arg Ala Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Tyr Asp Val Gly Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Lys Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  26
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Arg Ser Met Val Arg Gly Val Ile Ile Pro Phe Asn Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  27
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain

<400>  27

Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  28
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR1

<400>  28

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  29
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR2

<400>  29

Ile Tyr Ala Asp Gly Ser Thr 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR3

<400>  30

Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10          


<210>  31
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR1

<400>  31

Glu Ser Val Ser Asn Asp 
1               5       


<210>  32
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR2

<400>  32

Tyr Ala Phe 
1           


<210>  33
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR3

<400>  33

His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  34
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain

<400>  34

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  35
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain

<400>  35

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  36
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR1

<400>  36

Gly Gly Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR2

<400>  37

Ile Ile Pro Met Phe Asp Thr Ala 
1               5               


<210>  38
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain CDR3

<400>  38

Ala Arg Ala Glu His Ser Ser Thr Gly Thr Phe Asp Tyr 
1               5                   10              


<210>  39
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR1

<400>  39

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  40
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR2

<400>  40

Ala Ala Ser 
1           


<210>  41
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain CDR3

<400>  41

Gln Gln Ala Asn His Leu Pro Phe Thr 
1               5                   


<210>  42
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ile Pro Met Phe Asp Thr Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ala Ile Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Glu His Ser Ser Thr Gly Thr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light Chain

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn His Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


