                               SEQUENCE LISTING

<110> THE BROAD INSTITUTE, INC.
 
<120> COMPOSITIONS AND METHODS FOR TREATING A NEURODEGENERATIVE OR
      DEVELOPMENTAL DISORDER

<130> 167741-037001PCT

<140> PCT/US2022/021667
<141> 2022-03-24

<150> 63/165,919
<151> 2021-03-25

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 770
<212> PRT
<213> Homo sapiens

<400> 1
Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210> 2
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 2
agagcaagga cgcggcggat cccactcgca cagcagcgca ctcggtgccc cgcgcagggt       60

cgcagatgct gcccggtttg gcactgctcc tgctggccgc ctggacggct cgggcgctgg      120

aggtacccac tgatggtaat gctggcctgc tggctgaacc ccagattgcc atgttctgtg      180

gcagactgaa catgcacatg aatgtccaga atgggaagtg ggattcagat ccatcaggga      240

ccaaaacctg cattgatacc aaggaaggca tcctgcagta ttgccaagaa gtctaccctg      300

aactgcagat caccaatgtg gtagaagcca accaaccagt gaccatccag aactggtgca      360

agcggggccg caagcagtgc aagacccatc cccactttgt gattccctac cgctgcttag      420

ttggtgagtt tgtaagtgat gcccttctcg ttcctgacaa gtgcaaattc ttacaccagg      480

agaggatgga tgtttgcgaa actcatcttc actggcacac cgtcgccaaa gagacatgca      540

gtgagaagag taccaacttg catgactacg gcatgttgct gccctgcgga attgacaagt      600

tccgaggggt agagtttgtg tgttgcccac tggctgaaga aagtgacaat gtggattctg      660

ctgatgcgga ggaggatgac tcggatgtct ggtggggcgg agcagacaca gactatgcag      720

atgggagtga agacaaagta gtagaagtag cagaggagga agaagtggct gaggtggaag      780

aagaagaagc cgatgatgac gaggacgatg aggatggtga tgaggtagag gaagaggctg      840

aggaacccta cgaagaagcc acagagagaa ccaccagcat tgccaccacc accaccacca      900

ccacagagtc tgtggaagag gtggttcgag aggtgtgctc tgaacaagcc gagacggggc      960

cgtgccgagc aatgatctcc cgctggtact ttgatgtgac tgaagggaag tgtgccccat     1020

tcttttacgg cggatgtggc ggcaaccgga acaactttga cacagaagag tactgcatgg     1080

ccgtgtgtgg cagcgccatg tcccaaagtt tactcaagac tacccaggaa cctcttgccc     1140

gagatcctgt taaactccct acaacagcag ccagtacccc tgatgccgtt gacaagtatc     1200

tcgagacacc tggggatgag aatgaacatg cccatttcca gaaagccaaa gagaggcttg     1260

aggccaagca ccgagagaga atgtcccagg tcatgagaga atgggaagag gcagaacgtc     1320

aagcaaagaa cttgcctaaa gctgataaga aggcagttat ccagcatttc caggagaaag     1380

tggaatcttt ggaacaggaa gcagccaacg agagacagca gctggtggag acacacatgg     1440

ccagagtgga agccatgctc aatgaccgcc gccgcctggc cctggagaac tacatcaccg     1500

ctctgcaggc tgttcctcct cggcctcgtc acgtgttcaa tatgctaaag aagtatgtcc     1560

gcgcagaaca gaaggacaga cagcacaccc taaagcattt cgagcatgtg cgcatggtgg     1620

atcccaagaa agccgctcag atccggtccc aggttatgac acacctccgt gtgatttatg     1680

agcgcatgaa tcagtctctc tccctgctct acaacgtgcc tgcagtggcc gaggagattc     1740

aggatgaagt tgatgagctg cttcagaaag agcaaaacta ttcagatgac gtcttggcca     1800

acatgattag tgaaccaagg atcagttacg gaaacgatgc tctcatgcca tctttgaccg     1860

aaacgaaaac caccgtggag ctccttcccg tgaatggaga gttcagcctg gacgatctcc     1920

agccgtggca ttcttttggg gctgactctg tgccagccaa cacagaaaac gaagttgagc     1980

ctgttgatgc ccgccctgct gccgaccgag gactgaccac tcgaccaggt tctgggttga     2040

caaatatcaa gacggaggag atctctgaag tgaagatgga tgcagaattc cgacatgact     2100

caggatatga agttcatcat caaaaattgg tgttctttgc agaagatgtg ggttcaaaca     2160

aaggtgcaat cattggactc atggtgggcg gtgttgtcat agcgacagtg atcgtcatca     2220

ccttggtgat gctgaagaag aaacagtaca catccattca tcatggtgtg gtggaggttg     2280

acgccgctgt caccccagag gagcgccacc tgtccaagat gcagcagaac ggctacgaaa     2340

atccaaccta caagttcttt gagcagatgc agaactag                             2378


<210> 3
<211> 763
<212> PRT
<213> Homo sapiens

<400> 3
Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ser Ser Gly Thr Ser Asn Ser Gly Arg Ala Arg 
        515                 520                 525             


Ser Asp Pro Thr His Gln His Arg His Ser Gly Gly His Phe Thr Ala 
    530                 535                 540                 


Ala Val Gln Ala Met Asp Cys Glu Thr His Ser Pro Gln Val Arg Gln 
545                 550                 555                 560 


Gln Phe Pro Ala Pro Leu Gly Trp Ser Gly Thr Glu Ala Pro Thr Gln 
                565                 570                 575     


Val Thr Val Glu Thr His Pro Val Gln Glu Thr Thr Phe His Val Ala 
            580                 585                 590         


Pro Gln Gln Asn Ala Leu His His His His Gly Asn Ser Ser His His 
        595                 600                 605             


His His His His His His His His His His His Gly Gln Gln Ala Leu 
    610                 615                 620                 


Gly Asn Arg Thr Arg Pro Arg Val Tyr Asn Ser Pro Thr Asn Ser Ser 
625                 630                 635                 640 


Ser Thr Gln Asp Ser Met Glu Val Gly His Ser His His Ser Met Thr 
                645                 650                 655     


Ser Leu Ser Ser Ser Thr Thr Ser Ser Ser Thr Ser Ser Ser Ser Thr 
            660                 665                 670         


Gly Asn Gln Gly Asn Gln Ala Tyr Gln Asn Arg Pro Val Ala Ala Asn 
        675                 680                 685             


Thr Leu Asp Phe Gly Gln Asn Gly Ala Met Asp Val Asn Leu Thr Val 
    690                 695                 700                 


Tyr Ser Asn Pro Arg Gln Glu Thr Gly Ile Ala Gly His Pro Thr Tyr 
705                 710                 715                 720 


Gln Phe Ser Ala Asn Thr Gly Pro Ala His Tyr Met Thr Glu Gly His 
                725                 730                 735     


Leu Thr Met Arg Gln Gly Ala Asp Arg Glu Glu Ser Pro Met Thr Gly 
            740                 745                 750         


Val Cys Val Gln Gln Ser Pro Val Ala Ser Ser 
        755                 760             


<210> 4
<211> 2422
<212> DNA
<213> Homo sapiens

<400> 4
gttatagttt tgccgctgga ctcttccctc ccttccccca ccccatcagg atgatatgag       60

acttgaaaga agacgatgca tacaggagga gagacttcag catgcaaacc ttcatctgtt      120

cggcttgcac cgtcattttc attccatgct gctggccttc agatggctgg acagatgccc      180

cattcacatc agtacagtga ccgtcgccag ccaaacataa gtgaccaaca ggtttctgcc      240

ttatcatatt ctgaccagat tcagcaacct ctaactaacc aggtgatgcc tgatattgtc      300

atgttacaga ggcggatgcc ccaaaccttc cgtgacccag caactgctcc cctgagaaaa      360

ctttctgttg acttgatcaa aacatacaag catattaatg aggtttacta tgcaaaaaag      420

aagcgaagac accaacaggg ccagggagac gattctagtc ataagaagga acggaaggtt      480

tacaatgatg gttatgatga tgataactat gattatattg taaaaaacgg agaaaagtgg      540

atggatcgtt acgaaattga ctccttgata ggcaaaggtt cctttggaca ggttgtaaag      600

gcatatgatc gtgtggagca agaatgggtt gccattaaaa taataaagaa caagaaggct      660

tttctgaatc aagcacagat agaagtgcga cttcttgagc tcatgaacaa acatgacact      720

gaaatgaaat actacatagt gcatttgaaa cgccacttta tgtttcgaaa ccatctctgt      780

ttagtttttg aaatgctgtc ctacaacctc tatgacttgc tgagaaacac caatttccga      840

ggggtctctt tgaacctaac acgaaagttt gcgcaacaga tgtgcactgc actgcttttc      900

cttgcgactc cagaacttag tatcattcac tgtgatctaa aacctgaaaa tatccttctt      960

tgtaacccca aacgcagtgc aatcaagata gttgactttg gcagttcttg tcagttgggg     1020

cagaggatat accagtatat tcagagtcgc ttttatcggt ctccagaggt gctactggga     1080

atgccttatg accttgccat tgatatgtgg tccctcgggt gtattttggt tgaaatgcac     1140

actggagaac ctctgttcag tggtgccaat gaggtagatc agatgaataa aatagtggaa     1200

gttctgggta ttccacctgc tcatattctt gaccaagcac caaaagcaag aaagttcttt     1260

gagaagttgc cagatggcac ttggaactta aagaagacca aagatggaaa acgggagtac     1320

aaaccaccag gaacccgtaa acttcataac attcttggag tggaaacagg aggacctggt     1380

gggcgacgtg ctggggagtc aggtcatacg gtcgctgact acttgaagtt caaagacctc     1440

attttaagga tgcttgatta tgaccccaaa actcgaattc aaccttatta tgctctgcag     1500

cacagtttct tcaagaaaac agctgatgaa ggtacaaata caagtaatag tgtatctaca     1560

agccccgcca tggagcagtc tcagtcttcg ggcaccacct ccagtacatc gtcaagctca     1620

ggtggctcat cggggacaag caacagtggg agagcccggt cggatccgac gcaccagcat     1680

cggcacagtg gtgggcactt cacagctgcc gtgcaggcca tggactgcga gacacacagt     1740

ccccaggtgc gtcagcaatt tcctgctcct cttggttggt caggcactga agctcctaca     1800

caggtcactg ttgaaactca tcctgttcaa gaaacaacct ttcatgtagc ccctcaacag     1860

aatgcattgc atcatcacca tggtaacagt tcccatcatc accaccacca ccaccaccat     1920

caccaccacc atggacaaca agccttgggt aaccggacca ggccaagggt ctacaattct     1980

ccaacgaata gctcctctac ccaagattct atggaggttg gccacagtca ccactccatg     2040

acatccctgt cttcctcaac gacttcttcc tcgacatctt cctcctctac tggtaaccaa     2100

ggcaatcagg cctaccacaa tcgcccagtg gctgctaata ccttggactt tggacagaat     2160

ggagctatgg acgttaattt gaccgtctac tccaatcccc gccaagagac tggcatagct     2220

ggacatccaa cataccaatt ttctgctaat acaggtcctg cacattacat gactgaagga     2280

catctgacga tgaggcaagg ggctgataga gaagagtccc ccatgacagg agtttgtgtg     2340

caacagagtc ctgtagctag ctcgtgacta cattgaaact tgagtttgtt tcttgtgtgt     2400

ttttatagaa gtggtgtttt tt                                              2422


<210> 5
<211> 632
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Glu Leu Val Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Phe Val Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg 
        35                  40                  45              


Phe Pro Pro Pro Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Glu Lys Glu Pro Cys Cys Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Ile Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Ile Glu Arg Leu 
            100                 105                 110         


Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp Thr Phe His Lys 
        115                 120                 125             


Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met Cys Ala Lys Glu 
    130                 135                 140                 


Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Phe Ser Val Thr 
145                 150                 155                 160 


Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser Ile Asn Glu Val 
                165                 170                 175     


Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His Phe Arg Ser Leu 
            180                 185                 190         


Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu Ala Ser Lys Gln 
        195                 200                 205             


Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His Glu Gln Phe Ile 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ala Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp Gln Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp Val Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Leu Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Ala 
305                 310                 315                 320 


Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile Met Pro Pro Asn 
                325                 330                 335     


Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn Ala Pro Glu Glu 
            340                 345                 350         


Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His Phe Ser Gln Pro 
        355                 360                 365             


Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser Ser Val Val Ala 
    370                 375                 380                 


Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln Gly Met Val Pro 
385                 390                 395                 400 


Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu 
                405                 410                 415     


Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu 
            420                 425                 430         


Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser 
        435                 440                 445             


Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp 
    450                 455                 460                 


Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly 
465                 470                 475                 480 


His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala 
                485                 490                 495     


Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp 
            500                 505                 510         


Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg 
        515                 520                 525             


Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg 
    530                 535                 540                 


Gly Arg Gly Gly Gly Phe Lys Gly Asn Asp Asp His Ser Arg Thr Asp 
545                 550                 555                 560 


Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly 
                565                 570                 575     


Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr 
            580                 585                 590         


Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly 
        595                 600                 605             


Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln 
    610                 615                 620                 


Gln Pro Leu Val Asn Gly Val Pro 
625                 630         


<210> 6
<211> 4362
<212> DNA
<213> Homo sapiens

<400> 6
acggcgagcg cgggcggcgg cggtgacgga ggcgccgctg ccagggggcg tgcggcagcg       60

cggcggcggc ggcggcggcg gcggcggcgg aggcggcggc ggcggcggcg gcggcggcgg      120

aggcggcggc ggcggcggcg gcggcggcgg ctgggcctcg agcgcccgca gcccacctct      180

cgggggcggg ctcccggcgc tagcagggct gaagagaaga tggaggagct ggtggtggaa      240

gtgcggggct ccaatggcgc tttctacaag gcatttgtaa aggatgttca tgaagattca      300

ataacagttg catttgaaaa caactggcag cctgataggc agattccatt tcatgatgtc      360

agattcccac ctcctgtagg ttataataaa gatataaatg aaagtgatga agttgaggtg      420

tattccagag caaatgaaaa agagccttgc tgttggtggt tagctaaagt gaggatgata      480

aagggtgagt tttatgtgat agaatatgca gcatgtgatg caacttacaa tgaaattgtc      540

acaattgaac gtctaagatc tgttaatccc aacaaacctg ccacaaaaga tactttccat      600

aagatcaagc tggatgtgcc agaagactta cggcaaatgt gtgccaaaga ggcggcacat      660

aaggatttta aaaaggcagt tggtgccttt tctgtaactt atgatccaga aaattatcag      720

cttgtcattt tgtccatcaa tgaagtcacc tcaaagcgag cacatatgct gattgacatg      780

cactttcgga gtctgcgcac taagttgtct ctgataatga gaaatgaaga agctagtaag      840

cagctggaga gttcaaggca gcttgcctcg agatttcatg aacagtttat cgtaagagaa      900

gatctgatgg gtctagctat tggtactcat ggtgctaata ttcagcaagc tagaaaagta      960

cctggggtca ctgctattga tctagatgaa gatacctgca catttcatat ttatggagag     1020

gatcaggatg cagtgaaaaa agctagaagc tttctcgaat ttgctgaaga tgtaatacaa     1080

gttccaagga acttagtagg caaagtaata ggaaaaaatg gaaagctgat tcaggagatt     1140

gtggacaagt caggagttgt gagggtgagg attgaggctg aaaatgagaa aaatgttcca     1200

caagaagagg aaattatgcc accaaattcc cttccttcca ataattcaag ggttggacct     1260

aatgccccag aagaaaaaaa acatttagat ataaaggaaa acagcaccca tttttctcaa     1320

cctaacagta caaaagtcca gagggtgtta gtggcttcat cagttgtagc aggggaatcc     1380

cagaaacctg aactcaaggc ttggcagggt atggtaccat ttgtttttgt gggaacaaag     1440

gacagcatcg ctaatgccac tgttcttttg gattatcacc tgaactattt aaaggaagta     1500

gaccagttgc gtttggagag attacaaatt gatgagcagt tgcgacagat tggagctagt     1560

tctagaccac caccaaatcg tacagataag gaaaaaagct atgtgactga tgatggtcaa     1620

ggaatgggtc gaggtagtag accttacaga aatagggggc acggcagacg cggtcctgga     1680

tatacttcag gaactaattc tgaagcatca aatgcttctg aaacagaatc tgaccacaga     1740

gacgaactca gtgattggtc attagctcca acagaggaag agagggagag cttcctgcgc     1800

agaggagacg gacggcggcg tggaggggga ggaagaggac aaggaggaag aggacgtgga     1860

ggaggcttca aaggaaacga cgatcactcc cgaacagata atcgtccacg taatccaaga     1920

gaggctaaag gaagaacaac agatggatcc cttcagatca gagttgactg caataatgaa     1980

aggagtgtcc acactaaaac attacagaat acctccagtg aaggtagtcg gctgcgcacg     2040

ggtaaagatc gtaaccagaa gaaagagaag ccagacagcg tggatggtca gcaaccactc     2100

gtgaatggag taccctaaac tgcataattc tgaagttata tttcctatac catttccgta     2160

attcttattc catattagaa aactttgtta ggccaaagac aaatagtagg caagatggca     2220

cagggcatga aatgaacaca aattatgcta agaatttttt attttttggt attggccata     2280

agcaacaatt ttcagatttg cacaaaaaga taccttaaaa tttgaaacat tgcttttaaa     2340

actacttagc acttcagggc agattttagt tttattttct aaagtactga gcagtgatat     2400

tctttgttaa tttggaccat tttcctgcat tgggtgatca ttcaccagta cattctcagt     2460

ttttcttaat atatagcatt tatggtaatc atattagact tctgttttca atctcgtata     2520

gaagtcttca tgaaatgcta tgtcatttca tgtcctgtgt cagtttatgt tttggtccac     2580

ttttccagta ttttagtgga ccctgaaatg tgtgtgatgt gacatttgtc attttcatta     2640

gcaaaaaaag ttgtatgatc tgtgcctttt ttatatcttg gcaggtagga atattatatt     2700

tggatgcaga gttcagggaa gataagttgg aaacactaaa tgttaaagat gtagcaaacc     2760

ctgtcaaaca ttagtacttt atagaagaat gcatgctttc catatttttt tccttacata     2820

aacatcaggt taggcagtat aaagaatagg acttgttttt gtttttgttt tgttgcactg     2880

aagtttgata aatagtgtta ttgagagaga tgtgtaattt ttctgtatag acaggagaag     2940

aaagaactat cttcatctga gagaggctaa aatgttttca gctaggaaca aatcttcctg     3000

gtcgaaagtt agtaggatat gcctgctctt tggcctgatg accaatttta acttagagct     3060

ttttttttta attttgtctg ccccaagttt tgtgaaattt ttcatatttt aatttcaagc     3120

ttattttgga gagataggaa ggtcatttcc atgtatgcat aataatcctg caaagtacag     3180

gtactttgtc taagaaacat tggaagcagg ttaaatgttt tgtaaacttt gaaatatatg     3240

gtctaatgtt taagcagaat tggaaaagac taagatcggt taacaaataa caactttttt     3300

ttcttttttt cttttgtttt ttgaagtgtt ggggtttggt tttgtttttt gagtcttttt     3360

tttttaagtg aaatttattg aggaaaaata tgtgaaggac cttcactcta agatgttata     3420

tttttcttaa aaagtaactc ctagtagggg taccactgaa tctgtacaga gccgtaaaaa     3480

ctgaagttct gcctctgatg tattttgtga gtttgtttct ttgaattttc attttacagt     3540

tacttttcct tgcatacaaa caagcatata aaatggcaac aaactgcaca tgatttcaca     3600

aatattaaaa agtcttttaa aaagtattgc caaacattaa tgttgatttc tagttattta     3660

ttctgggaat gtatagtatt tgaaaacaga aattggtacc ttgcacacat catctgtaag     3720

ctgtttggtt ttaaaatact gtagataatt aaccaaggta gaatgacctt gtaatgtaac     3780

tgctcttggg caatattctc tgtacatatt agcgacaaca gattggattt tatgttgaca     3840

tttgtttggt tatagtgcaa tatattttgt atgcaagcag tttcaataaa gtttgatctt     3900

cctctgctaa attgatgttg atgcaatcct tacaaatgat tgcttttaaa attttaagct     3960

aggaaaagaa atctatagaa agtgttctgt tacaaaatgt aactgttacc attggaaatt     4020

tcacgtcata ggaagttagc ctttatctac ccaactttca agaaggttct ttaataaagc     4080

gaaaactcaa ccaaatggta cttttccaca gtgtaccatt aaaatatgca ctagtctctt     4140

tttacaaggc tgtattcagc aagggcctaa cttgcttaaa gtgtaattac taacttctaa     4200

aactgtactt tgattcacat gttttcaaat ggagttggag ttcattcata ttacaatatt     4260

tgtgtgctaa acgtgtatgt ttttcagttc aaagtcatga tgtttttaaa atcttattaa     4320

agtttcaaaa atctgaagat tgtttatcta gatgtaaatt tt                        4362


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
agctcaatgg cggtaactcc                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gcgctgctgg gaaccggccg                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
caggtcgcac tgcctcgcga                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
agaccagaca ccccctcccg                                                   20


