                         SEQUENCE LISTING

<110>  COMBANGIO, INC.
 
<120>  COMPOSITIONS COMPRISING C-MET AGONIST ANTIBODIES AND METHODS FOR 
       USE IN OCULAR TREATMENT

<130>  121785-5007-WO

<150>  63/165,678
<151>  2021-03-24

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid - Heavy chain - Human IgG1

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Thr Ala Ser Trp Gly Arg Trp Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  2
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid - Heavy chain - Human IgG1

<400>  2
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg       60

tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atctctggca gcggcggcag cacatattac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaatcgtg      300

acagccagct ggggccgttg gttcgattct tggggacagg gcacactggt caccgtgtca      360

tctgccagca ccaagggccc ttccgtgttt ccactggccc cctcctctaa atccacatct      420

ggcggcaccg ccgccctggg ctgtctggtg aaggactact tcccagagcc tgtgacagtg      480

tcctggaact ctggcgccct gacatccggc gtgcacacat ttccagccgt gctgcagagc      540

tccggcctgt acagcctgtc tagcgtggtg acagtgccct cctctagcct gggcacacag      600

acctatatct gcaacgtgaa tcacaagcca agcaatacca aggtggacaa gaaggtggag      660

cccaagtcct gtgataagac acacacctgc cccccttgtc ctgctcccga gctgctgggc      720

ggccctagcg tgttcctgtt tccacccaag cctaaggaca ccctgatgat ctcccggaca      780

cccgaggtga cctgcgtggt ggtggacgtg tctcacgagg atcctgaggt gaagttcaac      840

tggtatgtgg atggcgtgga ggtgcacaat gccaagacca agcccagaga ggagcagtac      900

aactctacat atagggtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggagtata agtgcaaggt gtccaataag gccctgcccg cccccatcga gaagacaatc     1020

agcaaggcca agggccagcc tcgggagcca caggtgtaca ccctgcctcc atccagagac     1080

gagctgacaa agaaccaggt gtctctgaca tgtctggtga agggcttcta tcctagcgat     1140

atcgccgtgg agtgggagtc caatggccag ccagagaaca attacaagac cacaccccct     1200

gtgctggact ccgatggctc cttctttctg tattccaagc tgaccgtgga taagtctcgg     1260

tggcagcagg gcaacgtgtt cagctgttcc gtgatgcacg aagccctgca taatcactat     1320

actcagaaat ccctgtccct gtcacctgga aag                                  1353


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide

<400>  3

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  4
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide

<400>  4
atgggctggt catgcattat tctgtttctg gtcgcaactg ctacaggcgt gcatagt          57


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid - Heavy chain variable region

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Val Thr Ala Ser Trp Gly Arg Trp Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide - Heavy chain variable region

<400>  6
gaggtgcagc tggttgaatc tggcggagga ctggttcagc ctggcggatc tctgagactg       60

tcttgtgccg ccagcggctt cacctttagc agctacgcca tgagctgggt ccgacaggct      120

cctggcaaag gccttgaatg ggtgtccgcc atctctggca gcggcggcag cacatattac      180

gccgattctg tgaagggcag attcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagaatcgtg      300

acagccagct ggggccgttg gttcgattct tggggacagg gcacactggt caccgtgtca      360

tct                                                                    363


<210>  7
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide - Human IgG1 constant

<400>  7

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  8
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide - Human IgG1 constant

<400>  8
gccagcacca agggcccttc cgtgtttcca ctggccccct cctctaaatc cacatctggc       60

ggcaccgccg ccctgggctg tctggtgaag gactacttcc cagagcctgt gacagtgtcc      120

tggaactctg gcgccctgac atccggcgtg cacacatttc cagccgtgct gcagagctcc      180

ggcctgtaca gcctgtctag cgtggtgaca gtgccctcct ctagcctggg cacacagacc      240

tatatctgca acgtgaatca caagccaagc aataccaagg tggacaagaa ggtggagccc      300

aagtcctgtg ataagacaca cacctgcccc ccttgtcctg ctcccgagct gctgggcggc      360

cctagcgtgt tcctgtttcc acccaagcct aaggacaccc tgatgatctc ccggacaccc      420

gaggtgacct gcgtggtggt ggacgtgtct cacgaggatc ctgaggtgaa gttcaactgg      480

tatgtggatg gcgtggaggt gcacaatgcc aagaccaagc ccagagagga gcagtacaac      540

tctacatata gggtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag      600

gagtataagt gcaaggtgtc caataaggcc ctgcccgccc ccatcgagaa gacaatcagc      660

aaggccaagg gccagcctcg ggagccacag gtgtacaccc tgcctccatc cagagacgag      720

ctgacaaaga accaggtgtc tctgacatgt ctggtgaagg gcttctatcc tagcgatatc      780

gccgtggagt gggagtccaa tggccagcca gagaacaatt acaagaccac accccctgtg      840

ctggactccg atggctcctt ctttctgtat tccaagctga ccgtggataa gtctcggtgg      900

cagcagggca acgtgttcag ctgttccgtg atgcacgaag ccctgcataa tcactatact      960

cagaaatccc tgtccctgtc acctggaaag tga                                   993


<210>  9
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide - Light Chain - Human Ig Kappa 
       Constant

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  10
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide - Light Chain - Human Ig Kappa 
       Constant

<400>  10
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc      120

ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct      180

agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag agctacagca cccctttcac atttggccct      300

ggcaccaagg tggacatcaa gaggacagtg gccgccccaa gcgtgttcat ctttccccct      360

tccgacgagc agctgaagtc tggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cctcgggagg ccaaggtcca gtggaaggtg gataacgccc tgcagtctgg caatagccag      480

gagtccgtga ccgagcagga ctctaaggat agcacatatt ccctgtctag caccctgaca      540

ctgagcaagg ccgattacga gaagcacaag gtgtatgcct gtgaagtcac ccatcagggg      600

ctgtcatcac ccgtcactaa gtcattcaat cgcggagaat gc                         642


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  12
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide

<400>  12
atgggctggt catgtattat tctgtttctg gtcgcaactg ctacaggggt ccatagt          57


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide - Light chain variable region

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide - Light chain variable region

<400>  14
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgta gagccagcca gagcatcagc agctacctga actggtatca gcagaagccc      120

ggcaaggccc ctaaactgct gatctatgcc gccagctctc tgcagtctgg cgtgccatct      180

agattttccg gcagcggctc tggcaccgac ttcaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag agctacagca cccctttcac atttggccct      300

ggcaccaagg tggacatcaa g                                                321


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide - Human Ig kappa constant

<400>  15

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  16
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide - Human Ig kappa constant

<400>  16
aggacagtgg ccgccccaag cgtgttcatc tttccccctt ccgacgagca gctgaagtct       60

ggcaccgcca gcgtggtgtg cctgctgaac aacttctacc ctcgggaggc caaggtccag      120

tggaaggtgg ataacgccct gcagtctggc aatagccagg agtccgtgac cgagcaggac      180

tctaaggata gcacatattc cctgtctagc accctgacac tgagcaaggc cgattacgag      240

aagcacaagg tgtatgcctg tgaagtcacc catcaggggc tgtcatcacc cgtcactaag      300

tcattcaatc gcggagaatg ctga                                             324


<210>  17
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide--Heavy chain variable region 
       (human)-humanIgG1 constant

<400>  17

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ile Val Thr Ala Ser Trp Gly Arg Trp Phe Asp 
        115                 120                 125             


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  18
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid peptide

<400>  18
gaattccccg ccaccatggg ctggtcatgc attattctgt ttctggtcgc aactgctaca       60

ggcgtgcata ggaggtgcag ctggttgaat ctggcggagg actggttcag cctggcggat      120

ctctgagact gtcttgtgcc gccagcggct tcacctttag cagctacgcc atgagctggg      180

tccgacaggc tcctggcaaa ggccttgaat gggtgtccgc catctctggc agcggcggca      240

gcacatatta cgccgattct gtgaagggca gattcaccat cagccgggac aacagcaaga      300

acaccctgta cctgcagatg aacagcctga gagccgagga caccgccgtg tactactgtg      360

ccagaatcgt gacagccagc tggggccgtt ggttcgattc ttggggacag ggcacactgg      420

tcaccgtgtc atctgccagc accaagggcc cttccgtgtt tccactggcc ccctcctcta      480

aatccacatc tggcggcacc gccgccctgg gctgtctggt gaaggactac ttcccagagc      540

ctgtgacagt gtcctggaac tctggcgccc tgacatccgg cgtgcacaca tttccagccg      600

tgctgcagag ctccggcctg tacagcctgt ctagcgtggt gacagtgccc tcctctagcc      660

tgggcacaca gacctatatc tgcaacgtga atcacaagcc aagcaatacc aaggtggaca      720

agaaggtgga gcccaagtcc tgtgataaga cacacacctg ccccccttgt cctgctcccg      780

agctgctggg cggccctagc gtgttcctgt ttccacccgc ctaaggacac cctgatgatc      840

tcccggacac ccgaggtgac ctgcgtggtg gtggacgtgt ctcacgagga tcctgaggtg      900

aagttcaact ggtatgtgga tggcgtggag gtgcacaatg ccaagaccaa gcccagagag      960

gagcagtaca actctacata tagggtggtg agcgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggagtataa gtgcaaggtg tccaataagg ccctgcccgc ccccatcgag     1080

aagacaatca gcaaggccaa gggccagcct cgggagccac aggtgtacac cctgcctcca     1140

tccagagacg agctgacaaa gaaccaggtg tctctgacat gtctggtgaa gggcttctat     1200

cctagcgata tcgccgtgga gtgggagtcc aatggccagc cagagaacaa ttacaagacc     1260

acaccccctg tgctggactc cgatggctcc ttctttctgt attccaagct gaccgtggat     1320

aagtctcggt ggcagcaggg caacgtgttc agctgttccg tgatgcacga agccctgcat     1380

aatcactata ctcagaaatc cctgtccctg tcacctggaa ataagctt                  1428


<210>  19
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide - light chain variable region 
       (human)--human Ig kappa constant

<400>  19

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
            100                 105                 110         


Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  20
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid peptide

<400>  20

Gly Ala Ala Thr Thr Cys Cys Cys Gly Cys Cys Gly Cys Cys Ala Cys 
1               5                   10                  15      


Cys Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Cys Ala Thr Gly Thr 
            20                  25                  30          


Ala Thr Thr Ala Thr Thr Cys Thr Gly Thr Thr Thr Cys Thr Gly Gly 
        35                  40                  45              


Thr Cys Gly Cys Ala Ala Cys Thr Gly Cys Thr Ala Cys Ala Gly Gly 
    50                  55                  60                  


Gly Gly Thr Cys Cys Ala Thr Ala Gly Gly Ala Cys Ala Thr Cys Cys 
65                  70                  75                  80  


Ala Gly Ala Thr Gly Ala Cys Ala Cys Ala Gly Ala Gly Cys Cys Cys 
                85                  90                  95      


Thr Ala Gly Cys Ala Gly Cys Cys Thr Gly Thr Cys Thr Gly Cys Cys 
            100                 105                 110         


Ala Gly Cys Gly Thr Gly Gly Gly Ala Gly Ala Cys Ala Gly Ala Gly 
        115                 120                 125             


Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly Thr Ala Gly 
    130                 135                 140                 


Ala Gly Cys Cys Ala Gly Cys Cys Ala Gly Ala Gly Cys Ala Thr Cys 
145                 150                 155                 160 


Ala Gly Cys Ala Gly Cys Thr Ala Cys Cys Thr Gly Ala Ala Cys Thr 
                165                 170                 175     


Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys 
            180                 185                 190         


Cys Gly Gly Cys Ala Ala Gly Gly Cys Cys Cys Cys Thr Ala Ala Ala 
        195                 200                 205             


Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Thr Gly Cys Cys Gly 
    210                 215                 220                 


Cys Cys Ala Gly Cys Thr Cys Thr Cys Thr Gly Cys Ala Gly Thr Cys 
225                 230                 235                 240 


Thr Gly Gly Cys Gly Thr Gly Cys Cys Ala Thr Cys Thr Ala Gly Ala 
                245                 250                 255     


Thr Thr Thr Thr Cys Cys Gly Gly Cys Ala Gly Cys Gly Gly Cys Thr 
            260                 265                 270         


Cys Thr Gly Gly Cys Ala Cys Cys Gly Ala Cys Thr Thr Cys Ala Cys 
        275                 280                 285             


Cys Cys Thr Gly Ala Cys Cys Ala Thr Ala Thr Cys Thr Ala Gly Cys 
    290                 295                 300                 


Cys Thr Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Gly Ala Cys Thr 
305                 310                 315                 320 


Thr Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala Cys Thr Gly 
                325                 330                 335     


Cys Cys Ala Gly Cys Ala Gly Ala Gly Cys Thr Ala Cys Ala Gly Cys 
            340                 345                 350         


Ala Cys Cys Cys Cys Thr Thr Thr Cys Ala Cys Ala Thr Thr Thr Gly 
        355                 360                 365             


Gly Cys Cys Cys Thr Gly Gly Cys Ala Cys Cys Ala Ala Gly Gly Thr 
    370                 375                 380                 


Gly Gly Ala Cys Ala Thr Cys Ala Ala Gly Ala Gly Gly Ala Cys Ala 
385                 390                 395                 400 


Gly Thr Gly Gly Cys Cys Gly Cys Cys Cys Cys Ala Ala Gly Cys Gly 
                405                 410                 415     


Thr Gly Thr Thr Cys Ala Thr Cys Thr Thr Thr Cys Cys Cys Cys Cys 
            420                 425                 430         


Thr Thr Cys Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Thr Gly 
        435                 440                 445             


Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Cys Cys Ala 
    450                 455                 460                 


Gly Cys Gly Thr Gly Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr 
465                 470                 475                 480 


Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Thr 
                485                 490                 495     


Cys Gly Gly Gly Ala Gly Gly Cys Cys Ala Ala Gly Gly Thr Cys Cys 
            500                 505                 510         


Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly Ala Thr Ala Ala 
        515                 520                 525             


Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly Cys 
    530                 535                 540                 


Ala Ala Thr Ala Gly Cys Cys Ala Gly Gly Ala Gly Thr Cys Cys Gly 
545                 550                 555                 560 


Thr Gly Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly Ala Cys Thr Cys 
                565                 570                 575     


Thr Ala Ala Gly Gly Ala Thr Ala Gly Cys Ala Cys Ala Thr Ala Thr 
            580                 585                 590         


Thr Cys Cys Cys Thr Gly Thr Cys Thr Ala Gly Cys Ala Cys Cys Cys 
        595                 600                 605             


Thr Gly Ala Cys Ala Cys Thr Gly Ala Gly Cys Ala Ala Gly Gly Cys 
    610                 615                 620                 


Cys Gly Ala Thr Thr Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys 
625                 630                 635                 640 


Ala Ala Gly Gly Thr Gly Thr Ala Thr Gly Cys Cys Thr Gly Thr Gly 
                645                 650                 655     


Ala Ala Gly Thr Cys Ala Cys Cys Cys Ala Thr Cys Ala Gly Gly Gly 
            660                 665                 670         


Gly Cys Thr Gly Thr Cys Ala Thr Cys Ala Cys Cys Cys Gly Thr Cys 
        675                 680                 685             


Ala Cys Thr Ala Ala Gly Thr Cys Ala Thr Thr Cys Ala Ala Thr Cys 
    690                 695                 700                 


Gly Cys Gly Gly Ala Gly Ala Ala Thr Gly Ala Ala Gly Cys Thr Thr 
705                 710                 715                 720 


