                         SEQUENCE LISTING

<110>  The Regents of the University of California
       WITTSTEN, Axel Hyrenius
       ROYBAL, Kole T.
       GARCIA, Julia
       ZHU, Iowis
       LIU, Raymond
 
<120>  HYBHYBRID RECEPTORS WITH MULTIPLE TRANSCRIPTIONAL REGULATORS

<130>  048536-667001WO

<140>  PCT/US2022/021605
<141>  2022-03-23

<150>  63/165,428
<151>  2021-03-24

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser 
    


<210>  2
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265                 270     


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            20                  25          


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Phe Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
1               5                   10                  15      


Cys Gly Val Leu Leu 
            20      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Ser Lys Arg Lys Arg Lys His 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  7
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  9
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                165                 170                 175     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            180                 185                 190         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser 
    210     


<210>  10
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
1               5                   10                  15      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            20                  25                  30          


Gly Cys Glu Leu 
        35      


<210>  11
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            20                  25  


<210>  12
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu Pro Val Gln Thr Thr Gln Glu 
            20                  25                  30          


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        35                  40                  45              


Glu Leu 
    50  


<210>  13
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu Pro Val Gln Thr Thr Gln Glu 
            20                  25                  30          


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        35                  40                  45              


Glu Leu Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    50                  55                  60                  


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
65                  70                  75  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
1               5                   10          


<210>  15
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser 
    370                 375                 380                 


Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys 
385                 390                 395                 400 


Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys 
                405                 410                 415     


Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg 
            420                 425                 430         


Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu 
        435                 440                 445             


Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp 
    450                 455                 460                 


Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr 
465                 470                 475                 480 


Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg 
                485                 490                 495     


Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg 
            500                 505                 510         


Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg 
        515                 520                 525             


Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
545                 550                 555                 560 


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
                565                 570                 575     


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            580                 585                 590         


Asp Met Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys 
        595                 600                 605             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    610                 615                 620                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
625                 630                 635                 640 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                645                 650                 655     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            660                 665                 670         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        675                 680                 685             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    690                 695                 700                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715         


<210>  16
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu 
    450                 455                 460                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
465                 470                 475                 480 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                485                 490                 495     


Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser 
            500                 505                 510         


Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser 
        515                 520                 525             


Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys 
    530                 535                 540                 


Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu 
545                 550                 555                 560 


Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu 
                565                 570                 575     


Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu 
            580                 585                 590         


Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val 
        595                 600                 605             


Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met 
    610                 615                 620                 


Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu 
625                 630                 635                 640 


Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala 
                645                 650                 655     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            660                 665                 670         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        675                 680                 685             


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 715         


<210>  17
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu 
    450                 455                 460                 


Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu 
465                 470                 475                 480 


Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr 
                485                 490                 495     


Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu 
            500                 505                 510         


Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe 
        515                 520                 525             


Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp 
    530                 535                 540                 


Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys 
545                 550                 555                 560 


Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu 
                565                 570                 575     


Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser 
            580                 585                 590         


Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly 
        595                 600                 605             


Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    610                 615                 620                 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
625                 630                 635                 640 


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
                645                 650                 655     


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        675                 680                 685             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    690                 695                 700                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
705                 710                 715         


<210>  18
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser 
    370                 375                 380                 


Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser 
            500                 505                 510         


Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser 
        515                 520                 525             


Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys 
    530                 535                 540                 


Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu 
545                 550                 555                 560 


Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu 
                565                 570                 575     


Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu 
            580                 585                 590         


Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val 
        595                 600                 605             


Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met 
    610                 615                 620                 


Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu 
625                 630                 635                 640 


Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala 
                645                 650                 655     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            660                 665                 670         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        675                 680                 685             


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 715         


<210>  19
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
            340                 345                 350         


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
        355                 360                 365             


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
    370                 375                 380                 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
385                 390                 395                 400 


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
                405                 410                 415     


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
            420                 425                 430         


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
        435                 440                 445             


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
    450                 455                 460                 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
465                 470                 475                 480 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
                485                 490                 495     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            500                 505                 510         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        515                 520                 525             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    530                 535                 540                 


Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Lys Arg Gly Arg Lys 
545                 550                 555                 560 


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
                565                 570                 575     


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            580                 585                 590         


Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys 
        595                 600                 605             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    610                 615                 620                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
625                 630                 635                 640 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                645                 650                 655     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            660                 665                 670         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        675                 680                 685             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    690                 695                 700                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715         


<210>  20
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
            340                 345                 350         


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
        355                 360                 365             


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
    370                 375                 380                 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
385                 390                 395                 400 


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
                405                 410                 415     


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
            420                 425                 430         


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
        435                 440                 445             


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
    450                 455                 460                 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
465                 470                 475                 480 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
                485                 490                 495     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            500                 505                 510         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        515                 520                 525             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    530                 535                 540                 


Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser 
545                 550                 555                 560 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                565                 570                 575     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            580                 585                 590         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        595                 600                 605             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    610                 615                 620                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
625                 630                 635                 640 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                645                 650                 655     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        675                 680                 685             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    690                 695                 700                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
705                 710                 715         


<210>  21
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser 
    370                 375                 380                 


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
385                 390                 395                 400 


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
                405                 410                 415     


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
            420                 425                 430         


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
        435                 440                 445             


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
    450                 455                 460                 


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
465                 470                 475                 480 


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
                485                 490                 495     


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
            500                 505                 510         


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
        515                 520                 525             


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
    530                 535                 540                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
545                 550                 555                 560 


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
                565                 570                 575     


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            580                 585                 590         


Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser 
        595                 600                 605             


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
    610                 615                 620                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
625                 630                 635                 640 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                645                 650                 655     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            660                 665                 670         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        675                 680                 685             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    690                 695                 700                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715 


<210>  22
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    450                 455                 460                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
465                 470                 475                 480 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                485                 490                 495     


Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu 
            500                 505                 510         


Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu 
        515                 520                 525             


Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr 
    530                 535                 540                 


Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu 
545                 550                 555                 560 


Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe 
                565                 570                 575     


Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp 
            580                 585                 590         


Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys 
        595                 600                 605             


Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu 
    610                 615                 620                 


Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser 
625                 630                 635                 640 


Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly 
                645                 650                 655     


Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            660                 665                 670         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        675                 680                 685             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
    690                 695                 700                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 715 


<210>  23
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    450                 455                 460                 


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
465                 470                 475                 480 


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                485                 490                 495     


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            500                 505                 510         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        515                 520                 525             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    530                 535                 540                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
545                 550                 555                 560 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                565                 570                 575     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            580                 585                 590         


Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
    610                 615                 620                 


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
625                 630                 635                 640 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                645                 650                 655     


Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        675                 680                 685             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    690                 695                 700                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
705                 710                 715 


<210>  24
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu 
            500                 505                 510         


Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu 
        515                 520                 525             


Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr 
    530                 535                 540                 


Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu 
545                 550                 555                 560 


Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe 
                565                 570                 575     


Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp 
            580                 585                 590         


Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys 
        595                 600                 605             


Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu 
    610                 615                 620                 


Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser 
625                 630                 635                 640 


Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly 
                645                 650                 655     


Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            660                 665                 670         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        675                 680                 685             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
    690                 695                 700                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 715 


<210>  25
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Met Lys 
                325                 330                 335     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            340                 345                 350         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        355                 360                 365             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    370                 375                 380                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                405                 410                 415     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            420                 425                 430         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        435                 440                 445             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    450                 455                 460                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
465                 470                 475                 480 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    530                 535                 540                 


Ser Gly Ser Gly Ser Gly Ser Gly Ser Lys Arg Gly Arg Lys Lys Leu 
545                 550                 555                 560 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                565                 570                 575     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            580                 585                 590         


Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser 
        595                 600                 605             


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
    610                 615                 620                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
625                 630                 635                 640 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                645                 650                 655     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            660                 665                 670         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        675                 680                 685             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    690                 695                 700                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715 


<210>  26
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Met Lys 
                325                 330                 335     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            340                 345                 350         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        355                 360                 365             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    370                 375                 380                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                405                 410                 415     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            420                 425                 430         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        435                 440                 445             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    450                 455                 460                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
465                 470                 475                 480 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    530                 535                 540                 


Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser 
545                 550                 555                 560 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                565                 570                 575     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            580                 585                 590         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        595                 600                 605             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    610                 615                 620                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
625                 630                 635                 640 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                645                 650                 655     


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        675                 680                 685             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    690                 695                 700                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
705                 710                 715 


<210>  27
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser 
                485                 490                 495     


Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys 
            500                 505                 510         


Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys 
        515                 520                 525             


Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg 
    530                 535                 540                 


Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu 
545                 550                 555                 560 


Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp 
                565                 570                 575     


Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr 
            580                 585                 590         


Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg 
        595                 600                 605             


Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg 
    610                 615                 620                 


Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg 
625                 630                 635                 640 


Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
                645                 650                 655     


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
            660                 665                 670         


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
        675                 680                 685             


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
    690                 695                 700                 


Asp Met Leu Gly Ser 
705                 


<210>  28
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Arg 
        355                 360                 365             


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
    370                 375                 380                 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
385                 390                 395                 400 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
                405                 410                 415     


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
            420                 425                 430         


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
        435                 440                 445             


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
    450                 455                 460                 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln 
                485                 490                 495     


Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys 
            500                 505                 510         


Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser 
        515                 520                 525             


Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val 
    530                 535                 540                 


Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro 
545                 550                 555                 560 


Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile 
                565                 570                 575     


Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp 
            580                 585                 590         


Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr 
        595                 600                 605             


Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser 
    610                 615                 620                 


Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
                645                 650                 655     


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
            660                 665                 670         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
        675                 680                 685             


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695             


<210>  29
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser 
            500                 505                 510         


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
        515                 520                 525             


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
    530                 535                 540                 


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
545                 550                 555                 560 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
                565                 570                 575     


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
            580                 585                 590         


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
        595                 600                 605             


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
    610                 615                 620                 


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
625                 630                 635                 640 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
                645                 650                 655     


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
            660                 665                 670         


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        675                 680                 685             


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    690                 695                 700                 


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
705                 710                 715                 720 


Leu Gly Ser 
            


<210>  30
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
385                 390                 395                 400 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly 
                405                 410                 415     


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            420                 425                 430         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        435                 440                 445             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    450                 455                 460                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
465                 470                 475                 480 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                485                 490                 495     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            500                 505                 510         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        515                 520                 525             


Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile 
    530                 535                 540                 


Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys 
545                 550                 555                 560 


Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg 
                565                 570                 575     


Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr 
            580                 585                 590         


Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile 
        595                 600                 605             


Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln 
    610                 615                 620                 


Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn 
625                 630                 635                 640 


Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro 
                645                 650                 655     


Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu 
            660                 665                 670         


Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly 
        675                 680                 685             


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
    690                 695                 700                 


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
705                 710                 715                 720 


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
                725                 730                 735     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
            740                 745             


<210>  31
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Gly Ser Gly Ser Gly Ser 
            340                 345                 350         


Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                405                 410                 415     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            420                 425                 430         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        435                 440                 445             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    450                 455                 460                 


Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser 
465                 470                 475                 480 


Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser 
                485                 490                 495     


Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys 
            500                 505                 510         


Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu 
        515                 520                 525             


Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu 
    530                 535                 540                 


Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu 
545                 550                 555                 560 


Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val 
                565                 570                 575     


Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met 
            580                 585                 590         


Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu 
        595                 600                 605             


Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp 
625                 630                 635                 640 


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
                645                 650                 655     


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
            660                 665                 670         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
        675                 680                 685 


<210>  32
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly 
    370                 375                 380                 


Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg 
385                 390                 395                 400 


Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys 
                405                 410                 415     


Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser 
            420                 425                 430         


Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg 
        435                 440                 445             


Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met 
    450                 455                 460                 


Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly 
465                 470                 475                 480 


Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu 
                485                 490                 495     


Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile 
            500                 505                 510         


Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln 
        515                 520                 525             


Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    530                 535                 540                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
545                 550                 555                 560 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
                565                 570                 575     


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            580                 585                 590         


Met Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe 
        595                 600                 605             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
    610                 615                 620                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
625                 630                 635                 640 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                645                 650                 655     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            660                 665                 670         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        675                 680                 685             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    690                 695                 700                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715     


<210>  33
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  34
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu 
    450                 455                 460                 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
465                 470                 475                 480 


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
                485                 490                 495     


Ser Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile 
            500                 505                 510         


Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys 
        515                 520                 525             


Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg 
    530                 535                 540                 


Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr 
545                 550                 555                 560 


Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile 
                565                 570                 575     


Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln 
            580                 585                 590         


Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn 
        595                 600                 605             


Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro 
    610                 615                 620                 


Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu 
625                 630                 635                 640 


Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly 
                645                 650                 655     


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            660                 665                 670         


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        675                 680                 685             


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
    690                 695                 700                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 715     


<210>  35
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            340                 345                 350         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu 
    450                 455                 460                 


Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu 
465                 470                 475                 480 


Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr 
                485                 490                 495     


Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu 
            500                 505                 510         


Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe 
        515                 520                 525             


Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp 
    530                 535                 540                 


Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys 
545                 550                 555                 560 


Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu 
                565                 570                 575     


Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser 
            580                 585                 590         


Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly 
        595                 600                 605             


Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    610                 615                 620                 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
625                 630                 635                 640 


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
                645                 650                 655     


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        675                 680                 685             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    690                 695                 700                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
705                 710                 715     


<210>  36
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly 
    370                 375                 380                 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile 
            500                 505                 510         


Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys 
        515                 520                 525             


Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg 
    530                 535                 540                 


Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr 
545                 550                 555                 560 


Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile 
                565                 570                 575     


Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln 
            580                 585                 590         


Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn 
        595                 600                 605             


Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro 
    610                 615                 620                 


Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu 
625                 630                 635                 640 


Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly 
                645                 650                 655     


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            660                 665                 670         


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        675                 680                 685             


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
    690                 695                 700                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 715     


<210>  37
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
            340                 345                 350         


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
        355                 360                 365             


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
    370                 375                 380                 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
385                 390                 395                 400 


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
                405                 410                 415     


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
            420                 425                 430         


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
        435                 440                 445             


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
    450                 455                 460                 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
465                 470                 475                 480 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
                485                 490                 495     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            500                 505                 510         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        515                 520                 525             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    530                 535                 540                 


Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Ser Lys Arg Ser 
545                 550                 555                 560 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                565                 570                 575     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            580                 585                 590         


Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe 
        595                 600                 605             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
    610                 615                 620                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
625                 630                 635                 640 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                645                 650                 655     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            660                 665                 670         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        675                 680                 685             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    690                 695                 700                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 715     


<210>  38
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val 
    290                 295                 300                 


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
305                 310                 315                 320 


Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
            340                 345                 350         


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
        355                 360                 365             


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
    370                 375                 380                 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
385                 390                 395                 400 


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
                405                 410                 415     


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
            420                 425                 430         


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
        435                 440                 445             


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
    450                 455                 460                 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
465                 470                 475                 480 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
                485                 490                 495     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            500                 505                 510         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        515                 520                 525             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    530                 535                 540                 


Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser 
545                 550                 555                 560 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
                565                 570                 575     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            580                 585                 590         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        595                 600                 605             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    610                 615                 620                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
625                 630                 635                 640 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                645                 650                 655     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
        675                 680                 685             


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
    690                 695                 700                 


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
705                 710                 715     


<210>  39
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Met 
    370                 375                 380                 


Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys 
385                 390                 395                 400 


Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys 
                405                 410                 415     


Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu 
            420                 425                 430         


Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu 
        435                 440                 445             


Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu 
    450                 455                 460                 


Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe 
465                 470                 475                 480 


Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser 
                485                 490                 495     


Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala 
            500                 505                 510         


Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr 
        515                 520                 525             


Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala 
    530                 535                 540                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
545                 550                 555                 560 


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
                565                 570                 575     


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            580                 585                 590         


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg 
        595                 600                 605             


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
    610                 615                 620                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
625                 630                 635                 640 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                645                 650                 655     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            660                 665                 670         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        675                 680                 685             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    690                 695                 700                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 


<210>  40
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
    450                 455                 460                 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
465                 470                 475                 480 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly 
                485                 490                 495     


Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln 
            500                 505                 510         


Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys 
        515                 520                 525             


Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser 
    530                 535                 540                 


Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val 
545                 550                 555                 560 


Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro 
                565                 570                 575     


Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile 
            580                 585                 590         


Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp 
        595                 600                 605             


Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr 
    610                 615                 620                 


Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser 
625                 630                 635                 640 


Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser 
                645                 650                 655     


Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            660                 665                 670         


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
        675                 680                 685             


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
    690                 695                 700                 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 


<210>  41
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Val 
                325                 330                 335     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            340                 345                 350         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        355                 360                 365             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    370                 375                 380                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
385                 390                 395                 400 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                405                 410                 415     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            420                 425                 430         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala 
    450                 455                 460                 


Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro 
465                 470                 475                 480 


Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro 
                485                 490                 495     


Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu 
            500                 505                 510         


Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg 
        515                 520                 525             


Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys 
    530                 535                 540                 


Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala 
545                 550                 555                 560 


Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu 
                565                 570                 575     


Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn 
            580                 585                 590         


Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly 
        595                 600                 605             


Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
    610                 615                 620                 


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
625                 630                 635                 640 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                645                 650                 655     


Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly 
            660                 665                 670         


Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        675                 680                 685             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    690                 695                 700                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
705                 710                 


<210>  42
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly 
                485                 490                 495     


Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln 
            500                 505                 510         


Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys 
        515                 520                 525             


Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser 
    530                 535                 540                 


Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val 
545                 550                 555                 560 


Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro 
                565                 570                 575     


Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile 
            580                 585                 590         


Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp 
        595                 600                 605             


Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr 
    610                 615                 620                 


Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser 
625                 630                 635                 640 


Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser 
                645                 650                 655     


Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            660                 665                 670         


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
        675                 680                 685             


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
    690                 695                 700                 


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
705                 710                 


<210>  43
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Met Lys 
                325                 330                 335     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            340                 345                 350         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        355                 360                 365             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    370                 375                 380                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
385                 390                 395                 400 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                405                 410                 415     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            420                 425                 430         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        435                 440                 445             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    450                 455                 460                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
465                 470                 475                 480 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                485                 490                 495     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            500                 505                 510         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        515                 520                 525             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    530                 535                 540                 


Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Ser Lys Arg Ser Arg Leu 
545                 550                 555                 560 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                565                 570                 575     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            580                 585                 590         


Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg 
        595                 600                 605             


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
    610                 615                 620                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
625                 630                 635                 640 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                645                 650                 655     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            660                 665                 670         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        675                 680                 685             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    690                 695                 700                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
705                 710                 


<210>  44
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Val Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10                  15      


Leu His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile 
            20                  25                  30          


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
        35                  40                  45              


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
    50                  55                  60                  


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His 
65                  70                  75                  80  


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
            100                 105                 110         


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
145                 150                 155                 160 


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
                165                 170                 175     


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
            180                 185                 190         


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
        195                 200                 205             


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
    210                 215                 220                 


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
225                 230                 235                 240 


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
                245                 250                 255     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala 
    290                 295                 300                 


Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu 
305                 310                 315                 320 


Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Met 
                325                 330                 335     


Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys 
            340                 345                 350         


Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys 
        355                 360                 365             


Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu 
    370                 375                 380                 


Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu 
385                 390                 395                 400 


Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu 
                405                 410                 415     


Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe 
            420                 425                 430         


Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser 
        435                 440                 445             


Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala 
    450                 455                 460                 


Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr 
465                 470                 475                 480 


Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala 
                485                 490                 495     


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
            500                 505                 510         


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
        515                 520                 525             


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
    530                 535                 540                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg 
545                 550                 555                 560 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                565                 570                 575     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            580                 585                 590         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        595                 600                 605             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    610                 615                 620                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
625                 630                 635                 640 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                645                 650                 655     


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser 
            660                 665                 670         


Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        675                 680                 685             


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    690                 695                 700                 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
705                 710                 715 


<210>  45
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Gln 
            20                  25                  30          


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
        35                  40                  45              


Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
65                  70                  75                  80  


Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr Gly Arg 
                85                  90                  95      


Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr Met Glu Leu 
            100                 105                 110         


Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Ser Leu 
        115                 120                 125             


Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
                165                 170                 175     


Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
                245                 250                 255     


Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys 
        275 


<210>  46
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Gln 
            20                  25                  30          


Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
65                  70                  75                  80  


Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            100                 105                 110         


Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu 
        115                 120                 125             


Gly Asp Ser Ser Arg Trp Ser Tyr Asp Leu Trp Gly Arg Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
                165                 170                 175     


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
            180                 185                 190         


Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Val Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val 
    210                 215                 220                 


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
225                 230                 235                 240 


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
                245                 250                 255     


Tyr Thr Ile Ala Ser Thr Leu Val Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu 
        275 


<210>  47
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Gln 
            20                  25                  30          


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
        35                  40                  45              


Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
65                  70                  75                  80  


Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr Gly Arg 
                85                  90                  95      


Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr Met Glu Leu 
            100                 105                 110         


Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Ser Leu 
        115                 120                 125             


Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
                165                 170                 175     


Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
                245                 250                 255     


Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met 
    290                 295                 300                 


Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly 
305                 310                 315                 320 


Val Leu Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            340                 345                 350         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly 
        355                 360                 365             


Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser 
                485                 490                 495     


Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys 
            500                 505                 510         


Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu 
        515                 520                 525             


Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His 
    530                 535                 540                 


Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu 
545                 550                 555                 560 


Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser 
                565                 570                 575     


Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn 
            580                 585                 590         


Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp 
        595                 600                 605             


Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser 
    610                 615                 620                 


Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe 
                645                 650                 655     


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            660                 665                 670         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        675                 680                 685             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700         


<210>  48
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Gln 
            20                  25                  30          


Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
65                  70                  75                  80  


Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            100                 105                 110         


Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu 
        115                 120                 125             


Gly Asp Ser Ser Arg Trp Ser Tyr Asp Leu Trp Gly Arg Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
                165                 170                 175     


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
            180                 185                 190         


Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Val Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val 
    210                 215                 220                 


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
225                 230                 235                 240 


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
                245                 250                 255     


Tyr Thr Ile Ala Ser Thr Leu Val Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met 
    290                 295                 300                 


Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly 
305                 310                 315                 320 


Val Leu Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            340                 345                 350         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Gly Ser Gly Ser Gly 
        355                 360                 365             


Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser 
                485                 490                 495     


Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys 
            500                 505                 510         


Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu 
        515                 520                 525             


Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His 
    530                 535                 540                 


Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu 
545                 550                 555                 560 


Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser 
                565                 570                 575     


Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn 
            580                 585                 590         


Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp 
        595                 600                 605             


Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser 
    610                 615                 620                 


Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe 
                645                 650                 655     


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            660                 665                 670         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        675                 680                 685             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700         


<210>  49
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
1               5                   10                  15      


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            20                  25                  30          


Tyr Arg Ser 
        35  


<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
1               5                   10                  15      


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            20                  25                  30          


<210>  51
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Gly 
1               5                   10                  15      


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            20                  25                  30          


Ala Tyr Arg Ser 
        35      


<210>  52
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Ser Asp Tyr Met Asn Met Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
1               5                   10                  15      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            20                  25          


<210>  53
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
1               5                   10                  15      


Ala Ala Tyr Arg Ser 
            20      


<210>  54
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Leu Leu 
                325                 330                 335     


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            340                 345                 350         


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        355                 360                 365             


Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly 
                485                 490                 495     


Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg 
            500                 505                 510         


Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys 
        515                 520                 525             


Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser 
    530                 535                 540                 


Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg 
545                 550                 555                 560 


Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met 
                565                 570                 575     


Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly 
            580                 585                 590         


Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu 
        595                 600                 605             


Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile 
    610                 615                 620                 


Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln 
625                 630                 635                 640 


Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                645                 650                 655     


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
            660                 665                 670         


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
        675                 680                 685             


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    690                 695                 700                 


Met Leu Gly Ser 
705             


<210>  55
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Ser Asp 
                325                 330                 335     


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
            340                 345                 350         


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser 
        355                 360                 365             


Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys 
                485                 490                 495     


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
            500                 505                 510         


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
        515                 520                 525             


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
    530                 535                 540                 


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
545                 550                 555                 560 


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
                565                 570                 575     


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
            580                 585                 590         


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
        595                 600                 605             


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
    610                 615                 620                 


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
625                 630                 635                 640 


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
                645                 650                 655     


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            660                 665                 670         


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        675                 680                 685             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    690                 695                 700                 


Ser 
705 


<210>  56
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Gly Pro Thr 
            340                 345                 350         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        355                 360                 365             


Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser 
                485                 490                 495     


Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys 
            500                 505                 510         


Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys 
        515                 520                 525             


Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg 
    530                 535                 540                 


Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu 
545                 550                 555                 560 


Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp 
                565                 570                 575     


Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr 
            580                 585                 590         


Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg 
        595                 600                 605             


Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg 
    610                 615                 620                 


Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg 
625                 630                 635                 640 


Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly 
                645                 650                 655     


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
            660                 665                 670         


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
        675                 680                 685             


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
    690                 695                 700                 


Asp Met Leu Gly Ser 
705                 


<210>  57
<211>  700
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Ser Asp 
                325                 330                 335     


Tyr Met Asn Met Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            340                 345                 350         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly 
        355                 360                 365             


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser Ser Ile 
                485                 490                 495     


Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys 
            500                 505                 510         


Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg 
        515                 520                 525             


Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr 
    530                 535                 540                 


Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile 
545                 550                 555                 560 


Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln 
                565                 570                 575     


Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn 
            580                 585                 590         


Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro 
        595                 600                 605             


Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu 
    610                 615                 620                 


Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala Ala Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
                645                 650                 655     


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            660                 665                 670         


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        675                 680                 685             


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700 


<210>  58
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser 
        355                 360                 365             


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
385                 390                 395                 400 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                405                 410                 415     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile 
                485                 490                 495     


Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala 
            500                 505                 510         


Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys 
        515                 520                 525             


Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu 
    530                 535                 540                 


Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu 
545                 550                 555                 560 


Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu 
                565                 570                 575     


Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp 
            580                 585                 590         


Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His 
        595                 600                 605             


Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln 
    610                 615                 620                 


Arg Gln Leu Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly 
625                 630                 635                 640 


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
                645                 650                 655     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            660                 665                 670         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        675                 680                 685             


Leu Asp Met Leu Gly Ser 
    690                 


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu Pro Tyr Ala Pro 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu Tyr Met Phe Met 
            20                  25                  


<210>  61
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu Tyr Met Phe Met Thr Pro Arg 
            20                  25                  30          


Arg Pro 
        


<210>  62
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
1               5                   10                  15      


Glu Glu Glu Glu Gly Gly Cys Glu Leu Ala Ala Tyr Arg Ser 
            20                  25                  30  


<210>  63
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Pro Tyr Ala Pro Gly Ser Gly Ser Gly 
        355                 360                 365             


Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser 
                485                 490                 495     


Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys 
            500                 505                 510         


Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu 
        515                 520                 525             


Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His 
    530                 535                 540                 


Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu 
545                 550                 555                 560 


Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser 
                565                 570                 575     


Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn 
            580                 585                 590         


Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp 
        595                 600                 605             


Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser 
    610                 615                 620                 


Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe 
                645                 650                 655     


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            660                 665                 670         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        675                 680                 685             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700         


<210>  64
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Tyr Met Phe Met Gly Ser Gly Ser Gly 
        355                 360                 365             


Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu Ser 
                485                 490                 495     


Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys 
            500                 505                 510         


Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu 
        515                 520                 525             


Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His 
    530                 535                 540                 


Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu 
545                 550                 555                 560 


Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser 
                565                 570                 575     


Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn 
            580                 585                 590         


Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp 
        595                 600                 605             


Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser 
    610                 615                 620                 


Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala 
625                 630                 635                 640 


Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp Phe 
                645                 650                 655     


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
            660                 665                 670         


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        675                 680                 685             


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700         


<210>  65
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Tyr Met Phe Met Thr Pro Arg Arg Pro 
        355                 360                 365             


Gly Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser 
                485                 490                 495     


Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
            500                 505                 510         


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
        515                 520                 525             


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
    530                 535                 540                 


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
545                 550                 555                 560 


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
                565                 570                 575     


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
            580                 585                 590         


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
        595                 600                 605             


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
    610                 615                 620                 


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
625                 630                 635                 640 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
                645                 650                 655     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
            660                 665                 670         


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
        675                 680                 685             


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    690                 695                 700                 


Leu Gly Ser 
705         


<210>  66
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
65                  70                  75                  80  


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
145                 150                 155                 160 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
                165                 170                 175     


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
            180                 185                 190         


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
        195                 200                 205             


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
    210                 215                 220                 


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
225                 230                 235                 240 


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
                245                 250                 255     


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met Tyr Val Ala Ala 
    290                 295                 300                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
305                 310                 315                 320 


Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser Gly Ser Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Ala Ala Tyr Arg Ser Gly Ser Gly Ser 
        355                 360                 365             


Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Lys Leu Leu 
                485                 490                 495     


Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys 
            500                 505                 510         


Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp 
        515                 520                 525             


Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala 
    530                 535                 540                 


His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe 
545                 550                 555                 560 


Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp 
                565                 570                 575     


Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp 
            580                 585                 590         


Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr 
        595                 600                 605             


Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser 
    610                 615                 620                 


Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala 
625                 630                 635                 640 


Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu Asp Asp 
                645                 650                 655     


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
            660                 665                 670         


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        675                 680                 685             


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    690                 695                 700             


<210>  67
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Gln 
            20                  25                  30          


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
        35                  40                  45              


Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
65                  70                  75                  80  


Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe Thr Gly Arg 
                85                  90                  95      


Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr Met Glu Leu 
            100                 105                 110         


Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Ser Leu 
        115                 120                 125             


Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
                165                 170                 175     


Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys 
                245                 250                 255     


Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met 
    290                 295                 300                 


Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly 
305                 310                 315                 320 


Val Leu Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            340                 345                 350         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Pro Tyr Ala Pro Gly 
        355                 360                 365             


Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met 
                485                 490                 495     


Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys 
            500                 505                 510         


Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys 
        515                 520                 525             


Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu 
    530                 535                 540                 


Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu 
545                 550                 555                 560 


Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu 
                565                 570                 575     


Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe 
            580                 585                 590         


Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser 
        595                 600                 605             


Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala 
    610                 615                 620                 


Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr 
625                 630                 635                 640 


Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala 
                645                 650                 655     


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
            660                 665                 670         


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
        675                 680                 685             


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
    690                 695                 700                 


Gly Ser 
705     


<210>  68
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Gln 
            20                  25                  30          


Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
65                  70                  75                  80  


Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            100                 105                 110         


Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Glu 
        115                 120                 125             


Gly Asp Ser Ser Arg Trp Ser Tyr Asp Leu Trp Gly Arg Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
                165                 170                 175     


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
            180                 185                 190         


Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
        195                 200                 205             


Ala Pro Lys Val Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val 
    210                 215                 220                 


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
225                 230                 235                 240 


Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
                245                 250                 255     


Tyr Thr Ile Ala Ser Thr Leu Val Val Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Thr Val Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        275                 280                 285             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Phe Met 
    290                 295                 300                 


Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly 
305                 310                 315                 320 


Val Leu Leu Ser Lys Arg Lys Arg Lys His Gly Ser Gly Ser Gly Ser 
                325                 330                 335     


Gly Ser Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            340                 345                 350         


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Pro Tyr Ala Pro Gly 
        355                 360                 365             


Ser Gly Ser Gly Ser Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ser Gly Ser Gly Ser Met 
                485                 490                 495     


Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys 
            500                 505                 510         


Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys 
        515                 520                 525             


Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu 
    530                 535                 540                 


Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu 
545                 550                 555                 560 


Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu 
                565                 570                 575     


Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe 
            580                 585                 590         


Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser 
        595                 600                 605             


Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala 
    610                 615                 620                 


Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr 
625                 630                 635                 640 


Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala 
                645                 650                 655     


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
            660                 665                 670         


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
        675                 680                 685             


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
    690                 695                 700                 


Gly Ser 
705     


<210>  69
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  70

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  71
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71

Gly Gly Ala Gly Cys Ala Cys Thr Gly Thr Cys Cys Thr Cys Cys Gly 
1               5                   10                  15      


Ala Ala Cys Gly 
            20  


