                         SEQUENCE LISTING

<110>  ALECTOR LLC
        
<120>  ANTI-TMEM106B ANTIBODIES FOR TREATING AND PREVENTING CORONAVIRUS 
       INFECTIONS

<130>  4503.015PC03

<150>  US 63/318,068
<151>  2022-03-09

<150>  US 63/239,498
<151>  2021-09-01

<150>  US 63/164,873
<151>  2021-03-23

<160>  534   

<170>  PatentIn version 3.5

<210>  1
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TMEM106B

<400>  1

Met Gly Lys Ser Leu Ser His Leu Pro Leu His Ser Ser Lys Glu Asp 
1               5                   10                  15      


Ala Tyr Asp Gly Val Thr Ser Glu Asn Met Arg Asn Gly Leu Val Asn 
            20                  25                  30          


Ser Glu Val His Asn Glu Asp Gly Arg Asn Gly Asp Val Ser Gln Phe 
        35                  40                  45              


Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser Val Thr Cys Pro Thr Cys 
    50                  55                  60                  


Gln Gly Thr Gly Arg Ile Pro Arg Gly Gln Glu Asn Gln Leu Val Ala 
65                  70                  75                  80  


Leu Ile Pro Tyr Ser Asp Gln Arg Leu Arg Pro Arg Arg Thr Lys Leu 
                85                  90                  95      


Tyr Val Met Ala Ser Val Phe Val Cys Leu Leu Leu Ser Gly Leu Ala 
            100                 105                 110         


Val Phe Phe Leu Phe Pro Arg Ser Ile Asp Val Lys Tyr Ile Gly Val 
        115                 120                 125             


Lys Ser Ala Tyr Val Ser Tyr Asp Val Gln Lys Arg Thr Ile Tyr Leu 
    130                 135                 140                 


Asn Ile Thr Asn Thr Leu Asn Ile Thr Asn Asn Asn Tyr Tyr Ser Val 
145                 150                 155                 160 


Glu Val Glu Asn Ile Thr Ala Gln Val Gln Phe Ser Lys Thr Val Ile 
                165                 170                 175     


Gly Lys Ala Arg Leu Asn Asn Ile Thr Ile Ile Gly Pro Leu Asp Met 
            180                 185                 190         


Lys Gln Ile Asp Tyr Thr Val Pro Thr Val Ile Ala Glu Glu Met Ser 
        195                 200                 205             


Tyr Met Tyr Asp Phe Cys Thr Leu Ile Ser Ile Lys Val His Asn Ile 
    210                 215                 220                 


Val Leu Met Met Gln Val Thr Val Thr Thr Thr Tyr Phe Gly His Ser 
225                 230                 235                 240 


Glu Gln Ile Ser Gln Glu Arg Tyr Gln Tyr Val Asp Cys Gly Arg Asn 
                245                 250                 255     


Thr Thr Tyr Gln Leu Gly Gln Ser Glu Tyr Leu Asn Val Leu Gln Pro 
            260                 265                 270         


Gln Gln 
        


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-1, TM-14, TM-23, TM-26, TM-27, TM-82, TM-89

<400>  2

Asn Tyr Leu Ile Glu 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRD-H1 -- TM-2

<400>  3

Glu Tyr Pro Met His 
1               5   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-3

<400>  4

Thr Leu Gly Arg Gly Val Gly 
1               5           


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-4, TM-18, TM-87

<400>  5

Asp Tyr Tyr Met Asn 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-5

<400>  6

Thr Tyr Gly Ile Thr 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-6

<400>  7

Glu Tyr Thr Ile His 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-7, TM-28, TM-86

<400>  8

Asp Tyr Tyr Ile His 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-8

<400>  9

Asp Tyr Pro Met His 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-9, TM-25

<400>  10

Gly Tyr Gly Met Ser 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-10, TM-31

<400>  11

Ser Tyr Trp Met Asn 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-11, TM-24

<400>  12

Asp Tyr Gly Val His 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-12, TM-19, TM-32

<400>  13

Asp Tyr Tyr Met Tyr 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-13, TM-84

<400>  14

Thr Phe Pro Ile Glu 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-15

<400>  15

Asn Tyr Trp Ile Thr 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-16, TM-20

<400>  16

Asp Tyr Tyr Met His 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-17

<400>  17

Asp Tyr Leu Ile Glu 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-21, TM-66, TM-70, TM-71

<400>  18

Asn Tyr Ala Met Ser 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-22

<400>  19

Ser Tyr Tyr Ile His 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-29, TM-88

<400>  20

Asp Tyr Tyr Ile Asn 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-30

<400>  21

Asn Tyr Asp Val Asn 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-33

<400>  22

Asp Tyr Asn Met Asn 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-34

<400>  23

Asp Ser Gly Met Asp 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-35

<400>  24

Arg His Trp Met Gln 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-37, TM-56, TM-59, TM-64, TM-81

<400>  25

Ser Tyr Trp Met His 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-39

<400>  26

Asp Tyr Trp Met His 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-41

<400>  27

Asp Cys Tyr Met His 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-42, TM-45, TM-52, TM-72

<400>  28

Asn Tyr Trp Met His 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-44

<400>  29

Asp Tyr Gly Met His 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-46

<400>  30

Ser Phe Trp Met Asn 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-47, TM-50

<400>  31

Asn Tyr Gly Val His 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-48, TM-60, TM-90

<400>  32

Ser Tyr Asp Ile Asn 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-49

<400>  33

Arg Phe Trp Met His 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-51

<400>  34

Thr Tyr Trp Ile Asp 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-1

<400>  35

Val Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Asn Glu Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-2

<400>  36

Met Ile Tyr Thr Asn Thr Gly Glu Pro Thr Tyr Ala Ala Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-3

<400>  37

Lys Ile Trp Trp Asn Asp Asp Lys Phe Tyr Tyr Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-4

<400>  38

Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr His Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-5

<400>  39

Glu Ile Tyr Pro Arg Ser Asp Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-6

<400>  40

Trp Phe Tyr Pro Gly Ser Thr Tyr Ile Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-7

<400>  41

Leu Val Tyr Pro Tyr Asn Gly Asp Thr Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-8

<400>  42

Val Ile Tyr Thr Asp Thr Gly Glu Pro Lys Tyr Ala Glu Val Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-9

<400>  43

Thr Ile Ser Ser Gly Ser Phe Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-10

<400>  44

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-11, TM-24

<400>  45

Val Ile Trp Asn Asn Gly Asn Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-12

<400>  46

Arg Ile Asp Pro Glu Asp Gly Asp Ala Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-13, TM-84

<400>  47

Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-14

<400>  48

Val Ile Asn Pro Gly Gly Gly Asn Thr Asp Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-15

<400>  49

Asp Ile Tyr Pro Gly Ser Gly Asn Ser Asn Tyr Asn Glu Ser Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-16, TM-20

<400>  50

Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-17

<400>  51

Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-18

<400>  52

Asn Ile Asn Pro Asn Asn Gly Asp Ala Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-19

<400>  53

Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Asn Ala Pro Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-21

<400>  54

Phe Ile Ser Asp Gly Gly Gly Tyr Ile Tyr Tyr Ala Asp Asn Val Lys 
1               5                   10                  15      


Asp 
    


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-22

<400>  55

Trp Ile Tyr Pro Gly Asn Gly Ile Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-23, TM-26

<400>  56

Val Ile Asn Pro Gly Ser Gly Ile Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-25

<400>  57

Thr Ile Ser Ser Gly Gly Arg Tyr Thr Val Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-27

<400>  58

Val Ile Asn Pro Gly Ser Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-28

<400>  59

Leu Val Tyr Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-29

<400>  60

Arg Ile Tyr Pro Gly Ser Gly Tyr Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-30

<400>  61

Trp Ile Tyr Pro Arg Asp Gly Thr Thr Ile Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-31

<400>  62

Tyr Ile Asn Pro Thr Ser Gly Tyr Thr Arg Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-32

<400>  63

Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Tyr Val Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-33

<400>  64

Val Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-34

<400>  65

Tyr Ile Ser Ser Gly Ser Ser Thr Thr His Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-35

<400>  66

Glu Ile Leu Pro Gly Ser Asn Asn Ile Tyr Tyr Asn Glu Lys Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-37, TM-59

<400>  67

Tyr Val Asn Pro Ser Ser Gly Tyr Thr Lys Asn Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-39

<400>  68

Phe Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-41

<400>  69

Arg Ile Asp Pro Glu Asp Gly Thr Thr Asn Phe Ala Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-42, TM-45

<400>  70

Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-44

<400>  71

Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-46

<400>  72

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-47, TM-50

<400>  73

Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-48, TM-60

<400>  74

Trp Ile Tyr Pro Arg Asp Gly Asn Thr Gln Tyr Ile Glu Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-49

<400>  75

Asn Ile Asp Pro Ser Asp Ser Gln Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-51

<400>  76

Asn Met Phe Pro Gly Ser Ser Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-52

<400>  77

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  78
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-1

<400>  78

Arg Gly Tyr Thr Ile Tyr Asp Phe Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  79
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-2

<400>  79

Ala Gly Tyr 
1           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-3

<400>  80

Ile Ala Gly Gly Thr Gly Ala Ala Tyr 
1               5                   


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-4

<400>  81

Ala Ala Thr Val Val Ala Gly Phe Asp Tyr 
1               5                   10  


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-5

<400>  82

Ser Lys Gly Ser Gly Thr Gly Asp Tyr 
1               5                   


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-6

<400>  83

His Glu Glu Asp Tyr Ser Asn Trp Phe Pro Phe 
1               5                   10      


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-7

<400>  84

Thr Tyr Tyr Ala Asn Ser Pro Asp Tyr 
1               5                   


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-8

<400>  85

Arg Leu Ala Tyr 
1               


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-9

<400>  86

Gln Asn Phe Tyr Tyr Gly Cys Glu Asp Tyr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-10

<400>  87

Trp Gly His Tyr Asp Glu Ala Met Asp Asp 
1               5                   10  


<210>  88
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-11, TM-24

<400>  88

Ser Leu Arg Pro Leu His Phe Asp Tyr 
1               5                   


<210>  89
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-12

<400>  89

Arg Val Ile Tyr Asp Gly Tyr Tyr Arg Thr Met Asp Cys 
1               5                   10              


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-13, TM-84

<400>  90

Tyr Phe Tyr Gly Gly Met Asp Tyr 
1               5               


<210>  91
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-14

<400>  91

Ser Pro Tyr Ser Ser Tyr Val Gly Tyr Ala Val Asp Tyr 
1               5                   10              


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-15

<400>  92

Lys Ala Tyr Gly Gly Phe Pro Tyr 
1               5               


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-16, TM-20

<400>  93

Ser Gln Pro Phe Thr Tyr 
1               5       


<210>  94
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-17

<400>  94

Ser Ser Tyr Gly Val Tyr Val Ala Tyr Pro Met Asp Tyr 
1               5                   10              


<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-18

<400>  95

Glu Gly Gln Leu Arg Leu Arg Arg Val Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-19

<400>  96

Arg Ile Gly Asn Leu Tyr His Val Met Asp Tyr 
1               5                   10      


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-21

<400>  97

Asp Gly Gly Thr Gly Phe Thr Tyr 
1               5               


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-22

<400>  98

Pro Tyr Tyr Gly Ile Arg Asn Cys Tyr Phe Asp Val 
1               5                   10          


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-23, TM-26

<400>  99

Ser Asp Phe Ile Thr Thr Val Val Ala Asp Tyr 
1               5                   10      


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-25

<400>  100

Asp Asn Phe Tyr Ser Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-27

<400>  101

Ile Ile Tyr Asp His Asp Trp Tyr Phe Asp Val 
1               5                   10      


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-28

<400>  102

Ser Tyr Phe Ser Asn Pro Ile Gly Tyr 
1               5                   


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-29

<400>  103

His Tyr Thr Asn Pro Phe Ala Tyr 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-30

<400>  104

Thr Leu Pro Gln Ala Met Asp Tyr 
1               5               


<210>  105
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-31

<400>  105

Ser Pro Pro Thr Val Val Leu Ile Gly Tyr Phe Asp Tyr 
1               5                   10              


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-32

<400>  106

Arg Thr Trp Asp Leu Tyr Tyr Ala Val Asp Asn 
1               5                   10      


<210>  107
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-33

<400>  107

Ser Tyr 
1       


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-34

<400>  108

Arg Asp Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10  


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-35

<400>  109

Ser Leu Tyr Asp Tyr Asp Gly Val Phe Ala Tyr 
1               5                   10      


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-37, TM-42, TM-45, TM-56, TM-59

<400>  110

Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-39

<400>  111

Glu Ala Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-41

<400>  112

Glu Trp Asp Ser Gly Ala Tyr 
1               5           


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-44

<400>  113

Asn Tyr Gly Ser Pro Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-46

<400>  114

Gly Asp Gly Phe Ser Tyr Phe Asp Tyr 
1               5                   


<210>  115
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-47, TM-50

<400>  115

Glu Ala Lys Leu Leu Arg Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-48, TM-60

<400>  116

Trp Ile Phe Tyr Ala Met Asp Tyr 
1               5               


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-49

<400>  117

Leu Ile Thr Val Asp Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  118
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-51

<400>  118

Lys Glu Gly Leu Trp Thr Tyr Gly Tyr Asp Gly Gly Ala Trp Phe Ala 
1               5                   10                  15      


Tyr 
    


<210>  119
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-52

<400>  119

Arg Gly Tyr Tyr Gly Arg Ser Pro Phe Ala Tyr 
1               5                   10      


<210>  120
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-1

<400>  120

Arg Ser Ser Gln Ser Ile Val Tyr Asn Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-2

<400>  121

Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-3, TM-9

<400>  122

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  123
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-4

<400>  123

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-5

<400>  124

Arg Ala Ser Glu Asn Ile Tyr Ile Tyr Leu Ala 
1               5                   10      


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-6

<400>  125

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  126
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-7

<400>  126

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Arg Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-8, TM-31

<400>  127

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  128
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-10

<400>  128

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Lys Thr Tyr Leu His 
1               5                   10                  15      


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-11

<400>  129

Lys Ser Ser Gln Ser Leu Leu Asn Ser Asn Asn Leu Gln Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  130
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-12

<400>  130

Arg Ser Ser Gln Thr Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-13, TM-84

<400>  131

Arg Ala Ser Glu Asn Ile Tyr Ser Ser Leu Gly 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-14, TM-17

<400>  132

Arg Ala Ser Gln Asp Ile Gly Ser Asn Leu Asn 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-15

<400>  133

Arg Val Ser Glu Asn Ile Tyr Asn Asn Leu Ala 
1               5                   10      


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-16, TM-20

<400>  134

Ser Ala Ser Ser Ser Leu Asn Tyr Met Tyr 
1               5                   10  


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-18

<400>  135

Arg Ala Ser Lys Ser Val Ser Ile Ser Val Tyr Thr Tyr Val His 
1               5                   10                  15  


<210>  136
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-19

<400>  136

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  137
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-21, TM-25

<400>  137

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  138
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-22

<400>  138

Arg Ser Gly Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-23, TM-26

<400>  139

Arg Ser Ser Gln Ser Leu Thr Asn Tyr Tyr Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-24

<400>  140

Lys Ser Ser Gln Ser Leu Leu Asn Ser Asn Asn Gln Gln Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-27

<400>  141

Ser Ala Ser Ser Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-28, TM-61, TM-86

<400>  142

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-29

<400>  143

Arg Ser Ser Lys Ser Leu Leu His Tyr Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-30

<400>  144

Arg Ser Ser Gln Thr Ile Val His Arg Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  145
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-32

<400>  145

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-33

<400>  146

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-34

<400>  147

Arg Ala Thr Ser Ser Val Thr Tyr Met His 
1               5                   10  


<210>  148
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-35

<400>  148

Arg Ser Ser Gln Ser Ile Val His Arg Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  149
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-37, TM-59

<400>  149

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Ser Tyr 
1               5                   10                  15      


<210>  150
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-39

<400>  150

Arg Ser Ser Lys Thr Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  151
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-41, TM-44

<400>  151

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  152
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-42, TM-45

<400>  152

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-46

<400>  153

Cys Ala Ser Ser Arg Val Asn Tyr Met His 
1               5                   10  


<210>  154
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-47

<400>  154

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  155
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-48, TM-54, TM-60

<400>  155

Arg Ser Ser Gln Ser Ile Val His Gly Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-49, TM-62

<400>  156

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-50

<400>  157

Arg Ala Ser Gln Asp Ile Asn Asn Tyr Leu Tyr 
1               5                   10      


<210>  158
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-51

<400>  158

Lys Ser Ser Gln Ser Leu Arg Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-52

<400>  159

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-1, TM-22, TM-30, TM-32, TM-35, TM-48, TM-54, TM-60, 
       TM-69, TM-83, TM-94

<400>  160

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-2, TM-34

<400>  161

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-3

<400>  162

Gln Met Ser Ser Leu Ala Ser 
1               5           


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-4

<400>  163

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-5

<400>  164

Asn Gly Lys Met Leu Ala Glu 
1               5           


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-6

<400>  165

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-7, TM-28, TM-61, TM-86

<400>  166

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-8

<400>  167

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-9, TM-21, TM-25, TM-29

<400>  168

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-10, TM-12

<400>  169

Lys Ile Ser Asn Arg Phe Ser 
1               5           


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-11, TM-24

<400>  170

Phe Ala Ser Ile Arg Glu Ser 
1               5           


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-13, TM-15, TM-84

<400>  171

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-14, TM-17, TM-89

<400>  172

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-16, TM-20, TM-73

<400>  173

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-18

<400>  174

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-19

<400>  175

Lys Val Phe Asn Arg Phe Ser 
1               5           


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-23, TM-26, TM-66, TM-82

<400>  176

Gly Ile Ser Asn Arg Phe Ser 
1               5           


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-27

<400>  177

Arg Thr Ser Thr Leu Ala Ser 
1               5           


<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-31

<400>  178

Arg Gly Asn Gly Leu Val Asp 
1               5           


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-33

<400>  179

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  180
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-37, TM-39, TM-42, TM-45, TM-56, TM-59, TM-63, TM-64,
       TM-68, TM-78, TM-80

<400>  180

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-41, TM-44, TM-47, TM-51

<400>  181

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-46, TM-49, TM-52, TM-62

<400>  182

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-50

<400>  183

Tyr Thr Ser Met Leu His Ser 
1               5           


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-1

<400>  184

Phe Gln Val Ser His Val Pro Phe Thr 
1               5                   


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-2

<400>  185

Gln Gln Trp Ser Ser Asn Pro Ser Thr 
1               5                   


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-3, TM-9

<400>  186

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-4

<400>  187

Val Leu Trp Tyr Ser Asn His Leu Val 
1               5                   


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-5

<400>  188

Gln His His Tyr Gly Ser Pro Pro Ala 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-6

<400>  189

Gln Gln Tyr Trp Ser Ser Pro Tyr Thr 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-7, TM-28, TM-86

<400>  190

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-8

<400>  191

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-10

<400>  192

Ser Gln Ile Thr His Val Pro Trp Thr 
1               5                   


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-11

<400>  193

Gln Gln His Tyr Asn Thr Pro Phe Thr 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-12, TM-35

<400>  194

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  195
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-13

<400>  195

Gln His Leu Trp Ser Ile Pro Trp Thr 
1               5                   


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-14, TM-17, TM-89

<400>  196

Leu Gln Tyr Ala Ser Ser Pro Arg Thr 
1               5                   


<210>  197
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-15

<400>  197

Gln His Phe Trp Asp Thr Pro Phe Thr 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-16, TM-20

<400>  198

Gln Gln Trp Thr Ser Phe Pro Pro Thr 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-18

<400>  199

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-19, TM-32

<400>  200

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-21

<400>  201

Val Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-22, TM-54

<400>  202

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-23, TM-26

<400>  203

Leu Gln Gly Thr His Gln Pro Arg Thr 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-24, TM-81

<400>  204

Gln Gln His Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  205
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-25

<400>  205

Ala Gln Asn Leu Glu Leu Trp Thr 
1               5               


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-27

<400>  206

Gln Gln Tyr His Ser Tyr Pro Arg Thr 
1               5                   


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-29

<400>  207

Ala Gln Asn Leu Glu Leu Pro Tyr Thr 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-30

<400>  208

Phe Gln Gly Ser His Leu Pro Trp Thr 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-31

<400>  209

Leu Gln Tyr Asp Glu Phe Pro Phe Thr 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-33

<400>  210

Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-34

<400>  211

Gln Gln Trp Ser Ser Asn Pro Tyr Thr 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-37, TM-42, TM-45, TM-56, TM-59

<400>  212

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  213
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-39

<400>  213

Met Gln His Leu Asp Tyr Pro Tyr Thr 
1               5                   


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-41

<400>  214

Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  215
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-44

<400>  215

Gln Gln Tyr Tyr Ser Tyr Pro Thr 
1               5               


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-46

<400>  216

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-47

<400>  217

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-48, TM-60

<400>  218

Phe Gln Gly Ser His Leu Pro Tyr Thr 
1               5                   


<210>  219
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-49, TM-62

<400>  219

Gln Gln Tyr His Ser Tyr Pro Pro Thr 
1               5                   


<210>  220
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-50

<400>  220

Gln Gln Gly Ser Thr Leu Met Tyr Thr 
1               5                   


<210>  221
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-51

<400>  221

Lys Gln Ser Tyr Asn Leu Leu Thr 
1               5               


<210>  222
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-52

<400>  222

Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
1               5                   


<210>  223
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-54

<400>  223

Thr Tyr Asp Leu Asn 
1               5   


<210>  224
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-61

<400>  224

Asn Tyr Trp Met Asn 
1               5   


<210>  225
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-62

<400>  225

Arg Tyr Trp Met His 
1               5   


<210>  226
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-63

<400>  226

Ser Phe Trp Met His 
1               5   


<210>  227
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-65

<400>  227

Ser Ser Trp Met His 
1               5   


<210>  228
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-68

<400>  228

Asp Asp Tyr Met His 
1               5   


<210>  229
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-69

<400>  229

Ser Tyr Gly Val His 
1               5   


<210>  230
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-73

<400>  230

Ser His Trp Met His 
1               5   


<210>  231
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-74

<400>  231

Ser Tyr Val Ile His 
1               5   


<210>  232
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-75

<400>  232

Ser Tyr Val Met His 
1               5   


<210>  233
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-76

<400>  233

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  234
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-77

<400>  234

Asp Tyr Glu Met His 
1               5   


<210>  235
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-78

<400>  235

Asn His Trp Met His 
1               5   


<210>  236
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-79

<400>  236

Asn Tyr Val Met His 
1               5   


<210>  237
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-80

<400>  237

Thr Phe Trp Met His 
1               5   


<210>  238
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-83

<400>  238

Thr Tyr Trp Ile His 
1               5   


<210>  239
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-85

<400>  239

Gly Tyr Trp Met His 
1               5   


<210>  240
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-91

<400>  240

Ser Gly Tyr Tyr Trp Asp 
1               5       


<210>  241
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-92

<400>  241

Asp Tyr Thr Met Asp 
1               5   


<210>  242
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-93

<400>  242

Ser Tyr Gly Ile Ser 
1               5   


<210>  243
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 -- TM-94

<400>  243

Asp Tyr Asn Met Asp 
1               5   


<210>  244
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-54

<400>  244

Trp Ile Tyr Pro Arg Gly Gly Ser Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  245
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-56

<400>  245

Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Lys Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  246
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-61

<400>  246

Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Lys Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  247
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-62

<400>  247

Asn Ile Asp Pro Ser Asp Ser Glu Thr Gln Tyr Asn Pro Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  248
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-63

<400>  248

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  249
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-64

<400>  249

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Asn Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  250
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-65

<400>  250

Glu Ile Asn Pro Lys Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  251
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-66

<400>  251

Thr Ile Gly Ser Val Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  252
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-68

<400>  252

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  253
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-69

<400>  253

Ile Met Gly Trp Asp Asp Lys Lys Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  254
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-70, TM-71

<400>  254

Thr Ile Gly Tyr Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  255
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-72

<400>  255

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  256
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-73

<400>  256

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  257
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-74

<400>  257

Phe Ile Asn Pro Asn Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  258
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-75

<400>  258

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  259
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-76

<400>  259

His Ile Phe Trp Asp Asp Asp Lys Arg Tyr Asn Leu Phe Leu Lys Ser 
1               5                   10                  15      


<210>  260
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-77

<400>  260

Val Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  261
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-78

<400>  261

Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn His Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  262
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-79

<400>  262

His Ile Thr Pro His Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  263
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-80

<400>  263

Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Glu Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  264
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-81

<400>  264

Asn Ile Asp Pro Ser Asp Ser Glu Ile His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  265
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-82

<400>  265

Val Ile Asn Pro Gly Ser Gly Ile Thr Asp Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  266
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-83

<400>  266

Asn Ile Asn Pro Ser Asn Gly Asn Thr Lys Asn Asn Glu Arg Phe Lys 
1               5                   10                  15      


Thr 
    


<210>  267
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-85

<400>  267

Arg Ile Asp Pro Tyr Ser Gly Asp Thr Arg Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  268
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-86

<400>  268

Val Ile Ser Pro Tyr Asn Asp Asn Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  269
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-87

<400>  269

Val Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  270
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-88

<400>  270

Val Ile Asn Pro Tyr Ser Gly Ala Thr Tyr Tyr Thr Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  271
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-89

<400>  271

Val Ile Asn Pro Gly Ser Gly Gly Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  272
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-90

<400>  272

Trp Ile Tyr Pro Arg Asp Gly Asn Ala Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  273
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-91

<400>  273

Tyr Ile Ser Tyr Asp Gly Asn Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  274
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-92

<400>  274

His Ile Asn Pro Asn Asp Gly Gly Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  275
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-93

<400>  275

Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Glu Ser 
1               5                   10                  15      


<210>  276
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 -- TM-94

<400>  276

Asp Ile Asn Pro Tyr Asn Gly Gly Thr Leu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  277
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-54

<400>  277

Tyr Ser Ile Tyr Ala Met Asp Tyr 
1               5               


<210>  278
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-61

<400>  278

Trp Gly Gly Ser Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  279
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-62

<400>  279

Leu Thr Thr Leu Asp Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-63, TM-80

<400>  280

Ser Ser Asn Trp Asp Asn Phe Asp Tyr 
1               5                   


<210>  281
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-64

<400>  281

Ser Arg Gly Gly Thr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
1               5                   10                  


<210>  282
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-65

<400>  282

Pro Thr Trp Phe Thr Tyr 
1               5       


<210>  283
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-66

<400>  283

Gln Glu Gly Ser Ser His Phe Asp Tyr 
1               5                   


<210>  284
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-68

<400>  284

Pro Gln Thr Ala Thr Thr Cys 
1               5           


<210>  285
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-69

<400>  285

Glu Ala Gly Pro Tyr Gly Met Asp Tyr 
1               5                   


<210>  286
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-70, TM-71

<400>  286

Gln Asp Ser Asn Tyr Glu Gly Val Trp Phe Ala Tyr 
1               5                   10          


<210>  287
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-72, TM-78

<400>  287

Ser Arg Gly Gly Tyr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
1               5                   10                  


<210>  288
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-73

<400>  288

Asn Tyr His Gly Ser Gly Pro Pro Phe Ala His 
1               5                   10      


<210>  289
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-74

<400>  289

Pro Tyr Tyr Asp Tyr Glu Gly Tyr Thr Met Asp Tyr 
1               5                   10          


<210>  290
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-75

<400>  290

Gly Gly Trp Phe Pro Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  291
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-76

<400>  291

Met Gly Arg Gln Arg Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  292
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-77

<400>  292

Tyr Gly Ile Glu Gly Tyr 
1               5       


<210>  293
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-79

<400>  293

Ser Gly Gln Phe Gly Arg Gly Asp Tyr Phe His Tyr 
1               5                   10          


<210>  294
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-81

<400>  294

Ser Pro Ala Gly Gln Ile Leu Asp Tyr 
1               5                   


<210>  295
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-82

<400>  295

Ser Pro Phe Ile Thr Thr Val Val Ala Asp Tyr 
1               5                   10      


<210>  296
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-83

<400>  296

Gly Asp Tyr Tyr Gly Thr Ser Tyr Pro Phe 
1               5                   10  


<210>  297
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-85

<400>  297

Tyr Gly Leu Gly His Ala Met Asp Tyr 
1               5                   


<210>  298
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-86

<400>  298

Thr Tyr Tyr Ser Asn Tyr Phe Asp Tyr 
1               5                   


<210>  299
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-87

<400>  299

Gly Asn Tyr Asp Trp Tyr Phe Asp Val 
1               5                   


<210>  300
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-88

<400>  300

Gly Gly Tyr Asp Tyr Gly His Trp Tyr Phe Asp Val 
1               5                   10          


<210>  301
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-89

<400>  301

Asp Pro Tyr Ser Lys Tyr Val His Tyr Pro Met Asp Tyr 
1               5                   10              


<210>  302
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-90

<400>  302

Val Ser Asp Tyr His Gly Gly Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-91

<400>  303

Ala Val Tyr Ser Val Gly Phe Ala Tyr 
1               5                   


<210>  304
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-92

<400>  304

Trp Val Tyr Tyr Tyr Gly Ile Ser Tyr Glu Gly Gly Ala Met Asp Tyr 
1               5                   10                  15      


<210>  305
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-93

<400>  305

Asn Pro Pro Lys Ile Phe Tyr Asp Tyr Leu Met Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 -- TM-94

<400>  306

Val Gly Tyr His Gly Thr Pro Asp Tyr 
1               5                   


<210>  307
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-56

<400>  307

Arg Ser Ser Lys Ser Leu Leu Gln Asn Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  308
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-63

<400>  308

Arg Ser Ser Gln Ser Leu Leu His Val Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  309
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-64, TM-71, TM-72

<400>  309

Arg Ser Ser Lys Ser Leu Leu His Thr Asn Gly Asn Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  310
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-65

<400>  310

Arg Ala Ser Gln Asn Ile Asn Ile Trp Leu Ser 
1               5                   10      


<210>  311
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-66

<400>  311

Arg Ser Ser Gln Ser Leu Val Asn Ser Tyr Gly Lys Thr Phe Leu Ser 
1               5                   10                  15      


<210>  312
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-68

<400>  312

Ser Ser Ser Lys Ser Leu Leu His Ser Ser Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  313
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-69

<400>  313

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  314
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-70

<400>  314

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  315
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-73

<400>  315

Ser Ala Ser Ser Gly Ile Ser Tyr Ile Tyr 
1               5                   10  


<210>  316
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-74

<400>  316

Lys Ala Ser Gln Asn Val Arg Ser Ala Val Ala 
1               5                   10      


<210>  317
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-75

<400>  317

Arg Ala Ser Gln Ser Val Asp Tyr Asn Gly Ile Ser Tyr Met His 
1               5                   10                  15  


<210>  318
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-76

<400>  318

Ser Ala Ser Leu Ser Ile Ser Tyr Val His 
1               5                   10  


<210>  319
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-77

<400>  319

Lys Ser Ser Gln Ser Leu Phe His Ser Asn Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  320
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-78

<400>  320

Arg Ser Ser Lys Ser Leu Leu His Val Asn Gly Asn Thr Tyr Leu Phe 
1               5                   10                  15      


<210>  321
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-79

<400>  321

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Ser Ile Tyr Ile His 
1               5                   10                  15  


<210>  322
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-80

<400>  322

Arg Ser Ser Gln Ser Leu Leu His Val Asn Gly His Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  323
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-81

<400>  323

Lys Ser Ser Gln Ser Leu Leu Asn Ser Lys Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  324
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-82

<400>  324

Arg Ser Ser Gln Ser Leu Ala Asn Thr Tyr Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  325
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-83

<400>  325

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Thr Tyr Leu His 
1               5                   10                  15      


<210>  326
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-85

<400>  326

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-87

<400>  327

Arg Ala Ser Arg Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  328
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-88

<400>  328

Ile Thr Ser Ser Asp Ile Asp Asp His Met Asn 
1               5                   10      


<210>  329
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-89

<400>  329

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Asn 
1               5                   10      


<210>  330
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-90

<400>  330

Arg Ser Ser Gln Ser Phe Val His Gly Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  331
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-91

<400>  331

Lys Ala Ser Gln Asn Val Tyr Thr Asn Val Ala 
1               5                   10      


<210>  332
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-92

<400>  332

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  333
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-93

<400>  333

Lys Ala Ser Gln Asp Val Gly Ser Ala Val Ala 
1               5                   10      


<210>  334
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 -- TM-94

<400>  334

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  335
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-65

<400>  335

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  336
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-70

<400>  336

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  337
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-71, TM-72

<400>  337

Arg Lys Ser Asn Leu Ala Ser 
1               5           


<210>  338
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-74

<400>  338

Leu Ala Ser Asn Arg His Thr 
1               5           


<210>  339
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-75

<400>  339

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  340
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-76

<400>  340

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  341
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-77

<400>  341

Met Val Ser Lys Leu Glu Ser 
1               5           


<210>  342
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-79

<400>  342

Leu Thr Ser Asn Leu Glu Ser 
1               5           


<210>  343
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-81

<400>  343

Phe Ala Phe Phe Arg Glu Ser 
1               5           


<210>  344
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-85, TM-91

<400>  344

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  345
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-87, TM-92

<400>  345

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  346
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-88

<400>  346

Glu Gly Asn Ala Leu Arg Pro 
1               5           


<210>  347
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-90

<400>  347

Lys Val Ser His Arg Phe Ser 
1               5           


<210>  348
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 -- TM-93

<400>  348

Trp Ser Ser Thr Arg Leu Pro 
1               5           


<210>  349
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-61

<400>  349

Gln Asn Asp Ser Asn Tyr Pro Phe Thr 
1               5                   


<210>  350
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-63

<400>  350

Met Gln His Leu Gln Tyr Pro Phe Ser 
1               5                   


<210>  351
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-64, TM-71, TM-72, TM-78

<400>  351

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  352
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-65

<400>  352

Leu Gln Gly Gln Ser Tyr Pro Tyr Thr 
1               5                   


<210>  353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-66

<400>  353

Leu Gln Gly Thr His Pro Pro Leu Thr 
1               5                   


<210>  354
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-68

<400>  354

Ala Gln Met Leu Glu Arg Pro Trp Thr 
1               5                   


<210>  355
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-69

<400>  355

Ser Gln Asn Thr His Val Pro Leu Thr 
1               5                   


<210>  356
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-70

<400>  356

Gln Gln Ser Lys Asp Val Pro Trp Thr 
1               5                   


<210>  357
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-73

<400>  357

His Gln Trp Arg Ser Tyr Pro Pro Thr 
1               5                   


<210>  358
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-74

<400>  358

Leu Gln His Trp Lys Tyr Pro Phe Thr 
1               5                   


<210>  359
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-75

<400>  359

Gln Gln Ser Ile Glu Asp Pro Trp Thr 
1               5                   


<210>  360
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-76

<400>  360

His Gln Trp Ser Ile Tyr Arg Thr 
1               5               


<210>  361
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-77

<400>  361

Leu Gln Val Thr His Phe Pro Leu Thr 
1               5                   


<210>  362
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-79

<400>  362

Gln His Ser Gly Glu Leu Pro Trp Thr 
1               5                   


<210>  363
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-80

<400>  363

Met Gln His Leu Gln Tyr Pro Phe Thr 
1               5                   


<210>  364
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-82

<400>  364

Leu Gln Gly Thr His Pro Pro Arg Thr 
1               5                   


<210>  365
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-83

<400>  365

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-84

<400>  366

Gln His Leu Trp Ser Val Pro Trp Thr 
1               5                   


<210>  367
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-85, TM-91

<400>  367

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  368
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-87

<400>  368

Gln Gln His Asn Glu Tyr Pro Leu Thr 
1               5                   


<210>  369
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-88

<400>  369

Leu Gln Ser Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  370
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-90

<400>  370

Phe Gln Asn Ser His Val Pro His Thr 
1               5                   


<210>  371
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-92

<400>  371

Gln Gln His Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  372
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-93

<400>  372

Gln Gln Tyr Thr Ser Tyr Pro Leu Thr 
1               5                   


<210>  373
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 -- TM-94

<400>  373

Ser Gln Ser Thr His Val Tyr Thr 
1               5               


<210>  374
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-1

<400>  374

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Lys Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Thr Ile Tyr Asp Phe Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  375
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-2

<400>  375

His Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Arg Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asn Thr Gly Glu Pro Thr Tyr Ala Ala Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Gly Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Thr Ala Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210>  376
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-3

<400>  376

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Leu 
            20                  25                  30          


Gly Arg Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Lys Ile Trp Trp Asn Asp Asp Lys Phe Tyr Tyr Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ile 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ala Gly Gly Thr Gly Ala Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  377
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-4

<400>  377

Glu Val Gln Val Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Ser Tyr His Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Thr Val Val Ala Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  378
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-5

<400>  378

Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Lys Gln Arg Gly Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Lys Gly Ser Gly Thr Gly Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  379
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-6

<400>  379

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Ser Thr Tyr Ile Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Glu Glu Asp Tyr Ser Asn Trp Phe Pro Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  380
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-7

<400>  380

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Pro 
1               5                   10                  15      


Pro Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Leu Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Tyr Pro Tyr Asn Gly Asp Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Tyr Ala Asn Ser Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  381
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-8

<400>  381

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Thr Asp Thr Gly Glu Pro Lys Tyr Ala Glu Val Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Arg Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210>  382
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-9

<400>  382

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Ser Phe Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asn Phe Tyr Tyr Gly Cys Glu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  383
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-10

<400>  383

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Ile His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly His Tyr Asp Glu Ala Met Asp Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  384
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-11, TM-24

<400>  384

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Gln Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Asn Asn Gly Asn Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Thr Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Ser Leu Arg Pro Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  385
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-12

<400>  385

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Gln Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Asp Ala Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Arg Val Ile Tyr Asp Gly Tyr Tyr Arg Thr Met Asp Cys Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  386
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-13

<400>  386

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Pro Ile Glu Trp Met Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Asp Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Tyr Gly Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  387
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-14

<400>  387

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Gly Gly Asn Thr Asp Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Pro Tyr Ser Ser Tyr Val Gly Tyr Ala Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  388
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-15

<400>  388

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Asn Ser Asn Tyr Asn Glu Ser Phe 
    50                  55                  60                  


Lys Arg Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Gln Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Ala Tyr Gly Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  389
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-16, TM-20

<400>  389

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ser Asp Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gln Pro Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  390
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-17

<400>  390

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ile Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asp Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Val Arg Ser Ser Tyr Gly Val Tyr Val Ala Tyr Pro Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  391
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-18

<400>  391

Glu Val Arg Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Val Asn Ile Asn Pro Asn Asn Gly Asp Ala Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gln Leu Arg Leu Arg Arg Val Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  392
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-19

<400>  392

Asp Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Asn Ala Pro Lys Phe 
    50                  55                  60                  


Arg Gly Met Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Arg Ile Gly Asn Leu Tyr His Val Met Asp Tyr Trp Gly His 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  393
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-21

<400>  393

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Glu Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asp Gly Gly Gly Tyr Ile Tyr Tyr Ala Asp Asn Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Arg His Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Thr Gly Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Val 
        115         


<210>  394
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-22

<400>  394

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Gly Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Tyr Gly Ile Arg Asn Cys Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  395
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-23, TM-26

<400>  395

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ile Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asp Phe Ile Thr Thr Val Val Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  396
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-25

<400>  396

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Arg Tyr Thr Val Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Phe Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Leu Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ala 
        115                 


<210>  397
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-27

<400>  397

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Leu Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ile Ile Tyr Asp His Asp Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  398
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-28

<400>  398

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Pro 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Met Ala Ser Val Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Tyr Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Phe Ser Asn Pro Ile Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Glu 
        115             


<210>  399
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-29

<400>  399

Gln Val Gln Leu Arg Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Tyr Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Gly Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asn His Tyr Thr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  400
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-30

<400>  400

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Asp Asn Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asp Val Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Thr Thr Ile Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      


Ala Arg Thr Leu Pro Gln Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  401
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-31

<400>  401

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Thr Ser Gly Tyr Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Pro Thr Val Val Leu Ile Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  402
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-32

<400>  402

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ile Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Tyr Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ile Gly Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Arg Thr Trp Asp Leu Tyr Tyr Ala Val Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  403
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-33

<400>  403

Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asn Tyr Gly Thr Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110     


<210>  404
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-34

<400>  404

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Ser 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Phe 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Thr His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  405
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-35

<400>  405

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Pro Gly Tyr Thr Phe Thr Arg His 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asn Asn Ile Tyr Tyr Asn Glu Lys Val 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Tyr Asp Tyr Asp Gly Val Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  406
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-37

<400>  406

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asn Pro Ser Ser Gly Tyr Thr Lys Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  407
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-39

<400>  407

His Val Gln Arg Gln Gln Ser Gly Thr Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  408
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-41

<400>  408

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Ile Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Cys 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Thr Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Thr Thr Asn Phe Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Trp Asp Ser Gly Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  409
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-42, TM-45

<400>  409

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Lys Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  410
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-44

<400>  410

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr Gly Ser Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  411
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-46

<400>  411

Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Phe 
            20                  25                  30          


Trp Met Asn Trp Val Lys Leu Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asp Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Phe Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ile Leu Thr Val Ser Ser 
        115             


<210>  412
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-47

<400>  412

Gln Val Gln Leu Lys Glu Ser Gly Pro Val Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Glu Ala Lys Leu Leu Arg Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  413
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-48, TM-60

<400>  413

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asn Thr Gln Tyr Ile Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Ile Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  414
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-49

<400>  414

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Phe 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Gln Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ile Thr Val Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  415
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-50

<400>  415

Gln Val Gln Leu Lys Glu Ser Gly Pro Val Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Glu Ala Lys Leu Leu Arg Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  416
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-51

<400>  416

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Met Phe Pro Gly Ser Ser Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Glu Gly Leu Trp Thr Tyr Gly Tyr Asp Gly Gly Ala Trp 
            100                 105                 110         


Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125     


<210>  417
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-52

<400>  417

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Val Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Tyr Gly Arg Ser Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  418
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-1

<400>  418

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  419
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-2

<400>  419

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Phe Leu Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Phe Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Ser Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  420
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-3

<400>  420

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Ser Gln Met Ser Ser Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Gly Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Phe Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  421
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-4

<400>  421

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  422
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-5

<400>  422

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ile Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Thr Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Gly Lys Met Leu Ala Glu Asn Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ser Pro Pro 
                85                  90                  95      


Ala Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  423
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-6

<400>  423

Asp Ile Gln Met Ser Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  424
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-7

<400>  424

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  425
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-8

<400>  425

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105         


<210>  426
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-9

<400>  426

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  427
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-10

<400>  427

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu His Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ile 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ser Lys 
            100                 105                 110         


<210>  428
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-11

<400>  428

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met His Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Asn Leu Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Thr Leu Leu Val Tyr Phe Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  429
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-12

<400>  429

Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Lys Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Asp Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  430
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-13

<400>  430

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Gln Gly Glu Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Leu Trp Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  431
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-14

<400>  431

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asn 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Val Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  432
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-15

<400>  432

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Val Ser Glu Asn Ile Tyr Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Glu Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Asp Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  433
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-16

<400>  433

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Leu Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Phe Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  434
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-17

<400>  434

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asn 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  435
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-18

<400>  435

Asp Ile Val Leu Ala Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ile Ser 
            20                  25                  30          


Val Tyr Thr Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  436
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-19

<400>  436

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Asp Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  437
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-20

<400>  437

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Leu Thr Met Thr Cys Ser Ala Ser Ser Ser Leu Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Phe Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  438
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-21

<400>  438

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  439
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-22

<400>  439

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Ile Ser Cys Arg Ser Gly Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  440
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-23, TM-26

<400>  440

Asp Ile Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Thr Asn Tyr 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Gln Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  441
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-24

<400>  441

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Arg 
    


<210>  442
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-25

<400>  442

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  443
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-27

<400>  443

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  444
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-28

<400>  444

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  445
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-29

<400>  445

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Tyr 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  446
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-30

<400>  446

Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  447
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-31

<400>  447

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Gly Asn Gly Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe 
                85                  90                  95      


Thr Phe Ala Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  448
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-32

<400>  448

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Asp Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  449
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-33

<400>  449

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Thr Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  450
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-34

<400>  450

Gln Ile Val Leu Ser Gln Ser Pro Val Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Thr Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Leu Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  451
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-35

<400>  451

Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  452
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-37, TM-59

<400>  452

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Ser Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  453
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-39

<400>  453

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Asp Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Gln Leu Glu Ile Lys 
            100                 105                 110         


<210>  454
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-41

<400>  454

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Thr Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  455
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-42, TM-45

<400>  455

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  456
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-44

<400>  456

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  457
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-46

<400>  457

Gln Ile Val Leu Thr Gln Ser Pro Val Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Cys Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Ser Tyr Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  458
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-47

<400>  458

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  459
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-48

<400>  459

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asn Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  460
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-49

<400>  460

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile His 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  461
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-50

<400>  461

Asp Val Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Met Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser Thr Leu Met Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  462
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-51

<400>  462

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Arg Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  463
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-52

<400>  463

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Asn Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Ala Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  464
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-54

<400>  464

Gln Val Gln Met Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Asp Leu Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Gly Gly Ser Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Tyr Ser Ile Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  465
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-56

<400>  465

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Gly Tyr Ser Lys Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Tyr Ala Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  466
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-59

<400>  466

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asn Pro Ser Ser Gly Tyr Thr Lys Asn Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Ser Ile Ser Asp Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  467
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-61

<400>  467

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Asp Tyr Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Tyr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Gly Ser Arg Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  468
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-62

<400>  468

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr Gln Tyr Asn Pro Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Thr Leu Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  469
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-63

<400>  469

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Phe Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Asn Trp Asp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  470
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-64

<400>  470

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Phe Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Gly Thr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  471
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-65

<400>  471

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Lys Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Pro Thr Trp Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  472
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-66

<400>  472

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Glu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Val Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Glu Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  473
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-68

<400>  473

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Ser Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Pro Gln Thr Ala Thr Thr Cys Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  474
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-69

<400>  474

Gln Val Gln Leu Lys Glu Ser Gly Pro Asp Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Phe Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Met Gly Trp Asp Asp Lys Lys Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Glu Ala Gly Pro Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  475
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-70

<400>  475

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Tyr Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Tyr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Gly Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Ser Asn Tyr Glu Gly Val Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  476
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-71

<400>  476

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Tyr Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asp Ser Asn Tyr Glu Gly Val Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  477
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-72

<400>  477

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Ser Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Lys Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Gly Tyr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  478
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-73

<400>  478

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Lys His Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Tyr His Gly Ser Gly Pro Pro Phe Ala His Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  479
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-74

<400>  479

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Asn Pro Asn Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Asp Tyr Glu Gly Tyr Thr Met Asp Tyr Gly Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  480
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-75

<400>  480

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Trp Phe Pro Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  481
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-76

<400>  481

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Lys Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Trp Asp Asp Asp Lys Arg Tyr Asn Leu Phe 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Met Ile Thr Ser Val Asp Thr Thr Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Gly Arg Gln Arg Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120 


<210>  482
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-77

<400>  482

Gln Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Tyr Gly Ile Glu Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  483
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-78

<400>  483

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Asp Thr His Tyr Asn His Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Ile Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Gly Gly Tyr Tyr Asp Tyr Gly Glu Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  484
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-79

<400>  484

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Leu Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala His Ile Thr Pro His Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Gln Phe Gly Arg Gly Asp Tyr Phe His Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  485
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-80

<400>  485

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Glu Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Asn Trp Asp Asn Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Val Thr Val Ser Ser 
        115             


<210>  486
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-81

<400>  486

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Ile His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Ala Gly Gln Ile Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  487
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-82

<400>  487

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Ile Thr Asp Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Arg Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser Pro Phe Ile Thr Thr Val Val Ala Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  488
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-83

<400>  488

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Asn Thr Lys Asn Asn Glu Arg Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Asp Tyr Tyr Gly Thr Ser Tyr Pro Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  489
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-84

<400>  489

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Phe 
            20                  25                  30          


Pro Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Tyr Gly Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  490
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-85

<400>  490

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Ala Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Gly Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Ser Gly Asp Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Leu Gly His Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  491
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-86

<400>  491

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Arg Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Pro Tyr Asn Asp Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Thr Tyr Tyr Ser Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  492
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-87

<400>  492

Glu Val Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gly Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Gly Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  493
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-88

<400>  493

Glu Ala Gln Leu Gln Gln Ser Gly Pro Val Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Ser Gly Ala Thr Tyr Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Gln Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Tyr Gly His Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  494
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-89

<400>  494

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Ser Lys Tyr Val His Tyr Pro Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  495
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-90

<400>  495

Gln Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Arg Asp Gly Asn Ala Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asn Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Ser Asp Tyr His Gly Gly Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  496
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-91

<400>  496

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asp Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Asn Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Val Tyr Ser Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  497
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-92

<400>  497

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Lys Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asn Pro Asn Asp Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Val Tyr Tyr Tyr Gly Ile Ser Tyr Glu Gly Gly Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  498
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-93

<400>  498

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Glu 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Pro Pro Lys Ile Phe Tyr Asp Tyr Leu Met Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  499
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Chain -- TM-94

<400>  499

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Gly Thr Leu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Arg Ser Leu Thr Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Tyr His Gly Thr Pro Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  500
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-54

<400>  500

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  501
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-56

<400>  501

Asp Ile Glu Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Gln Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  502
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-60

<400>  502

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  503
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-61

<400>  503

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Ser Asn Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Met 
            100                 105                 110         


Lys 
    


<210>  504
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-62

<400>  504

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ala Gly Ser Ser Pro Lys Pro Trp Ile His 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Arg Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Val Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  505
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-63

<400>  505

Asp Ile Val Met Thr Gln Ala Ser Pro Ser Val Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Val 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Arg Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Gln Tyr Pro Phe Ser Phe Gly Ser Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  506
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-64

<400>  506

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Phe Trp Phe Leu Gln Arg Pro Gly Arg Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  507
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-65

<400>  507

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Ile Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Gly Gln Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Gly Ile Lys 
            100                 105         


<210>  508
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-66

<400>  508

Asp Val Val Val Thr Gln Thr Pro Pro Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Asn Ser 
            20                  25                  30          


Tyr Gly Lys Thr Phe Leu Ser Trp Tyr Leu His Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Met Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  509
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-68

<400>  509

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Val Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      


Leu Glu Arg Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  510
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-69

<400>  510

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  511
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-70

<400>  511

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Asp Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Ala Ile Lys 
            100                 105                 110     


<210>  512
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-71, TM-72

<400>  512

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Phe Trp Phe Ile Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro His Leu Leu Ile Tyr Arg Lys Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  513
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-73

<400>  513

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Gly Ile Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Glu Thr Ser Tyr Ser Leu Thr Ile Ser Arg Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Trp Arg Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105     


<210>  514
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-74

<400>  514

Asp Val Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Glu 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Ala Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Lys Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  515
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-75

<400>  515

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Phe Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Ile 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  516
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-76

<400>  516

Gln Ile Ile Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Leu Ser Ile Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ile Tyr Arg Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105 


<210>  517
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-77

<400>  517

Asp Val Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Met Val Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  518
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-78

<400>  518

Asp Ile Val Met Thr Gln Ala Thr Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Val 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Phe Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  519
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-79

<400>  519

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Ser Ile Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Gly 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Ala Arg Leu Glu Ile Lys 
            100                 105                 110     


<210>  520
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-80

<400>  520

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Val 
            20                  25                  30          


Asn Gly His Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Gln Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  521
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-81

<400>  521

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Lys Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Phe Leu Val Tyr Phe Ala Phe Phe Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  522
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-82

<400>  522

Asp Val Val Val Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Phe Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ala Asn Thr 
            20                  25                  30          


Tyr Gly Asn Thr Tyr Leu Ser Trp Tyr Leu His Thr Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Phe Gly Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Thr Ile Lys Pro Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Gly 
                85                  90                  95      


Thr His Pro Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110         


<210>  523
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-83

<400>  523

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  524
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-84

<400>  524

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Ser 
            20                  25                  30          


Leu Gly Trp Tyr His Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Leu Trp Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  525
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-85

<400>  525

Asp Ile Ala Met Ser Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105         


<210>  526
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-86

<400>  526

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp His Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  527
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-87

<400>  527

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Arg Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  528
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-88

<400>  528

Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Met Ala Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Ser Asp Ile Asp Asp His 
            20                  25                  30          


Met Asn Trp Tyr Arg Gln Lys Pro Gly Glu Pro Pro Glu Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Ala Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Ile Phe Thr Ile Glu Asn Ile Leu Ser 
65                  70                  75                  80  


Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  529
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-89

<400>  529

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  530
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-90

<400>  530

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Phe Val His Gly 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser His Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Asn 
                85                  90                  95      


Ser His Val Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  531
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-91

<400>  531

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Tyr Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  532
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-92

<400>  532

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  533
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-93

<400>  533

Asp Ile Val Met Thr Gln Ser His Lys Leu Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ser Ser Thr Arg Leu Pro Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Val Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  534
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Chain -- TM-94

<400>  534

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


