                         SEQUENCE LISTING

<110>  THE GENERAL HOSPITAL CORPORATION
 
<120>  COMPOSITIONS AND METHODS FOR PREVENTING OR DELAYING PUBERTY IN 
       PREPUBESCENT NON-HUMAN ANIMALS AND HUMANS

<130>  01133-0001-00PCT

<150>  US 63/164,254
<151>  2021-03-22

<150>  US 63/197,061
<151>  2021-06-04

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  588
<212>  PRT
<213>  Felis silvestris catus

<400>  1

Met Pro Gly Leu Leu Ser Pro Pro Ala Leu Val Leu Ser Val Met Gly 
1               5                   10                  15      


Ala Leu Leu Met Ala Gly Asp Pro Gly Glu Glu Val Ser Ser Thr Pro 
            20                  25                  30          


Ala Leu Pro Gly Gly Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe His 
        35                  40                  45              


Pro Asp Trp Asp Trp Gln Pro Pro Gly Ser Pro Gln Asp Pro Leu Cys 
    50                  55                  60                  


Leu Val Thr Leu Asp Arg Gly Gly Asn Gly Ser Gly Ser Pro Leu Arg 
65                  70                  75                  80  


Val Val Gly Ala Leu Arg Gly Tyr Glu His Ala Phe Leu Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Arg Trp Gly Pro His Gly Leu Ala Thr Phe Gly Val Cys 
            100                 105                 110         


Thr Pro Arg Asp Arg Gln Ala Ala Pro Phe Ser Leu Arg Gln Leu Gln 
        115                 120                 125             


Ala Trp Leu Gly Glu Pro Gly Gly Arg Arg Leu Val Val Leu His Leu 
    130                 135                 140                 


Glu Glu Val Thr Trp Glu Pro Thr Pro Ser Leu Lys Phe Gln Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Gly Ala Gly Pro Leu Glu Leu Ala Met Leu Val Leu Tyr 
                165                 170                 175     


Pro Gly Pro Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro Gly 
            180                 185                 190         


Thr Gln Ser Leu Cys Gln Ser Arg Asp Thr Arg Tyr Leu Val Leu Ala 
        195                 200                 205             


Val Asp His Pro Glu Gly Ala Trp Arg Ser Pro Gly Leu Thr Leu Thr 
    210                 215                 220                 


Leu Gln Pro Arg Arg Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu Gln 
225                 230                 235                 240 


Glu Leu Leu Phe Gly Pro Asp Pro Arg Cys Phe Thr Arg Met Thr Pro 
                245                 250                 255     


Ala Leu Leu Leu Leu Pro Gly Pro Ala Pro Ala Pro Leu Pro Ala Arg 
            260                 265                 270         


Gly Leu Leu Asp Gln Val Pro Leu Pro Pro Pro Arg Pro Ser Gln Glu 
        275                 280                 285             


Gln Ala Pro Glu Glu Pro Arg Ser Ser Ala Asp Pro Phe Leu Glu Thr 
    290                 295                 300                 


Leu Thr Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Ala Gln Ala Ser 
305                 310                 315                 320 


Pro Ala Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln 
                325                 330                 335     


Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Gln Glu Arg Leu Leu Asn 
            340                 345                 350         


Gly Gly Asp Glu Pro Leu Leu Leu Leu Leu Leu Pro Pro Ala Thr Pro 
        355                 360                 365             


Thr Ala Ala Ala Ala Ala Ala Gly Asp Pro Ala Pro Pro Arg Gly Pro 
    370                 375                 380                 


Ala Ser Ala Pro Trp Ala Ala Gly Leu Ala Arg Arg Val Ala Ala Glu 
385                 390                 395                 400 


Leu Gln Ala Ala Ala Ala Glu Leu Arg Gly Leu Pro Gly Leu Pro Pro 
                405                 410                 415     


Ala Ala Thr Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Asp 
            420                 425                 430         


Ser Gly Asp Ser Gly Asp Pro Gly Ala Pro Pro Gly Gly Pro Gly Gly 
        435                 440                 445             


Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala 
    450                 455                 460                 


Glu Trp Arg Gly Arg Glu Gln Ala Gly Pro Ala Arg Ala Gln Arg Ser 
465                 470                 475                 480 


Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser 
                485                 490                 495     


Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln 
            500                 505                 510         


Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn 
        515                 520                 525             


Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg 
    530                 535                 540                 


Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Ala 
545                 550                 555                 560 


Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His 
                565                 570                 575     


Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            580                 585             


<210>  2
<211>  572
<212>  PRT
<213>  Canis lupus familiaris

<400>  2

Met Gly Ala Leu Ala Leu Trp Pro Leu Ala Leu Ala Leu Ser Gly Met 
1               5                   10                  15      


Gly Pro Leu Leu Gly Ala Glu Ala Pro Gly Gly Glu Val Ser Gly Thr 
            20                  25                  30          


Pro Ala Ser Pro Gly Glu Pro Ala Thr Gly Thr Gly Gly Leu Leu Phe 
        35                  40                  45              


Gln Pro Asp Trp Asp Trp Pro Pro Ser Ala Pro Gln Asp Pro Leu Cys 
    50                  55                  60                  


Leu Val Thr Leu Asp Lys Gly Gly Asn Gly Ser Ser Pro Pro Leu Arg 
65                  70                  75                  80  


Val Ala Gly Ala Leu Arg Gly Tyr Glu His Thr Phe Leu Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Arg Trp Gly Pro His Asp Leu Ala Thr Phe Gly Ala Cys 
            100                 105                 110         


Ala Ala Ser Asp Gly Arg Thr Thr Gln Leu Ser Leu Arg Gln Leu Gln 
        115                 120                 125             


Ala Trp Leu Gly Ala Pro Gly Gly Arg Arg Leu Val Val Leu His Leu 
    130                 135                 140                 


Glu Glu Val Thr Trp Glu Pro Ala Leu Ser Leu Lys Phe Gln Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Gly Ala Ser Pro Leu Glu Leu Ala Leu Leu Val Leu Tyr 
                165                 170                 175     


Pro Gly Pro Gly Pro Glu Val Ala Val Thr Gly Ala Gly Leu Pro Gly 
            180                 185                 190         


Thr Gln Asn Leu Cys Arg Ser Arg Asn Thr Arg Tyr Leu Val Leu Ala 
        195                 200                 205             


Leu Asp His Pro Val Gly Ala Trp His Ser Pro Arg Val Thr Leu Thr 
    210                 215                 220                 


Val His Ala Arg Gly Asp Gly Ala Pro Leu Ser Thr Pro Gln Leu Gln 
225                 230                 235                 240 


Glu Leu Leu Phe Gly Pro Asp Ala Arg Cys Phe Thr Arg Met Thr Pro 
                245                 250                 255     


Ala Leu Leu Val Leu Arg Leu Pro Gly Pro Thr Ala Val Pro Ala Arg 
            260                 265                 270         


Gly Leu Leu Asp Leu Val Pro Phe Pro Pro Pro Arg Pro Ser Arg Glu 
        275                 280                 285             


Pro Ala Glu Pro Pro Pro Ser Ala Asp Pro Phe Leu Glu Thr Leu Thr 
    290                 295                 300                 


Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Thr Pro Ala Ser Pro Pro 
305                 310                 315                 320 


Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln Gly Leu 
                325                 330                 335     


Leu Asn Leu Ser Asp Pro Ala Thr Gln Glu Arg Leu Leu Gly Gly Glu 
            340                 345                 350         


Glu Pro Leu Leu Leu Leu Leu Pro Pro Pro Thr Ala Ala Ala Gly Pro 
        355                 360                 365             


Pro Ala Pro Pro Pro Arg Pro Ala Ser Ala Pro Trp Ala Ala Gly Leu 
    370                 375                 380                 


Ala Leu Arg Val Ala Ala Glu Leu Arg Ala Ala Ala Ala Glu Leu Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Leu Pro Pro Ala Ala Ala Pro Leu Leu Glu Arg Leu 
                405                 410                 415     


Leu Ala Leu Cys Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Asp 
            420                 425                 430         


Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala 
        435                 440                 445             


Glu Trp Arg Gly Arg Glu Arg Gly Gly Pro Pro Arg Ala Gln Arg Ser 
    450                 455                 460                 


Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser 
465                 470                 475                 480 


Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln 
                485                 490                 495     


Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn 
            500                 505                 510         


Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg 
        515                 520                 525             


Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Gly 
    530                 535                 540                 


Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His 
545                 550                 555                 560 


Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
                565                 570         


<210>  3
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary chimeric feline MIS amino acid sequence

<400>  3

Met Pro Gly Leu Leu Ser Pro Pro Ala Leu Val Leu Ser Val Met Gly 
1               5                   10                  15      


Ala Leu Leu Met Ala Gly Asp Pro Gly Glu Glu Val Ser Ser Thr Pro 
            20                  25                  30          


Ala Leu Pro Gly Gly Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe His 
        35                  40                  45              


Pro Asp Trp Asp Trp Gln Pro Pro Gly Ser Pro Gln Asp Pro Leu Cys 
    50                  55                  60                  


Leu Val Thr Leu Asp Arg Gly Gly Asn Gly Ser Gly Ser Pro Leu Arg 
65                  70                  75                  80  


Val Val Gly Ala Leu Arg Gly Tyr Glu His Ala Phe Leu Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Arg Trp Gly Pro His Gly Leu Ala Thr Phe Gly Val Cys 
            100                 105                 110         


Thr Pro Arg Asp Arg Gln Ala Ala Pro Phe Ser Leu Arg Gln Leu Gln 
        115                 120                 125             


Ala Trp Leu Gly Glu Pro Gly Gly Arg Arg Leu Val Val Leu His Leu 
    130                 135                 140                 


Glu Glu Val Thr Trp Glu Pro Thr Pro Ser Leu Lys Phe Gln Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Gly Ala Gly Pro Leu Glu Leu Ala Met Leu Val Leu Tyr 
                165                 170                 175     


Pro Gly Pro Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro Gly 
            180                 185                 190         


Thr Gln Ser Leu Cys Gln Ser Arg Asp Thr Arg Tyr Leu Val Leu Ala 
        195                 200                 205             


Val Asp His Pro Glu Gly Ala Trp Arg Ser Pro Gly Leu Thr Leu Thr 
    210                 215                 220                 


Leu Gln Pro Arg Arg Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu Gln 
225                 230                 235                 240 


Glu Leu Leu Phe Gly Pro Asp Pro Arg Cys Phe Thr Arg Met Thr Pro 
                245                 250                 255     


Ala Leu Leu Leu Leu Pro Gly Pro Ala Pro Ala Pro Leu Pro Ala Arg 
            260                 265                 270         


Gly Leu Leu Asp Gln Val Pro Leu Pro Pro Pro Arg Pro Ser Gln Glu 
        275                 280                 285             


Gln Ala Pro Glu Glu Pro Arg Ser Ser Ala Asp Pro Phe Leu Glu Thr 
    290                 295                 300                 


Leu Thr Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Ala Gln Ala Ser 
305                 310                 315                 320 


Pro Ala Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln 
                325                 330                 335     


Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Gln Glu Arg Leu Leu Asn 
            340                 345                 350         


Gly Gly Asp Glu Pro Leu Leu Leu Leu Leu Pro Pro Pro Thr Ala Ala 
        355                 360                 365             


Ala Gly Pro Pro Ala Pro Pro Pro Arg Pro Ala Ser Ala Pro Trp Ala 
    370                 375                 380                 


Ala Gly Leu Ala Leu Arg Val Ala Ala Glu Leu Arg Ala Ala Ala Ala 
385                 390                 395                 400 


Glu Leu Arg Gly Leu Pro Gly Leu Pro Pro Ala Thr Ala Pro Leu Leu 
                405                 410                 415     


Glu Arg Leu Leu Ala Leu Cys Pro Gly Gly Ser Gly Gly Ser Gly Gly 
            420                 425                 430         


Ser Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly 
        435                 440                 445             


Leu Arg Ala Glu Trp Arg Gly Arg Glu Arg Gly Gly Pro Pro Arg Ala 
    450                 455                 460                 


Gln Arg Ser Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg 
465                 470                 475                 480 


Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu 
                485                 490                 495     


Thr Tyr Gln Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser 
            500                 505                 510         


Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met 
        515                 520                 525             


Gln Ala Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr 
    530                 535                 540                 


Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser 
545                 550                 555                 560 


Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
                565                 570                 575 


<210>  4
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu Arg Ala Glu Glu Pro Ala Val 
            20                  25                  30          


Gly Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly 
        35                  40                  45              


Ser Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn 
    50                  55                  60                  


Gly Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu 
65                  70                  75                  80  


Gln Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp 
                85                  90                  95      


Leu Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu 
            100                 105                 110         


Pro Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln 
        115                 120                 125             


Arg Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro 
    130                 135                 140                 


Ser Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu 
145                 150                 155                 160 


Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val 
                165                 170                 175     


Thr Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp 
            180                 185                 190         


Thr Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg 
        195                 200                 205             


Gly Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg 
    210                 215                 220                 


Leu Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg 
225                 230                 235                 240 


Cys Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu 
                245                 250                 255     


Pro Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro 
            260                 265                 270         


Pro Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp 
        275                 280                 285             


Pro Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro 
    290                 295                 300                 


Pro Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu 
305                 310                 315                 320 


Ala Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu 
                325                 330                 335     


Glu Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro 
            340                 345                 350         


Thr Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser 
        355                 360                 365             


Ala Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
    370                 375                 380                 


Ala Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr 
385                 390                 395                 400 


Ala Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly 
                405                 410                 415     


Gly Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln 
            420                 425                 430         


Gly Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg 
        435                 440                 445             


Ala Gln Arg Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu 
    450                 455                 460                 


Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro 
465                 470                 475                 480 


Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln 
                485                 490                 495     


Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys 
            500                 505                 510         


Met Gln Val Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro 
        515                 520                 525             


Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile 
    530                 535                 540                 


Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 555                 560 


<210>  5
<211>  1767
<212>  DNA
<213>  Felis silvestris catus

<400>  5
atgcctggcc tgctgtcccc tcccgccctg gtgctgtccg tcatgggtgc cctgctgatg       60

gctggagacc ctggtgaaga agtgtcaagc accccagccc tgcctggagg acctgcaacc      120

ggcaccggag gcctgatctt ccacccagac tgggattggc agccacctgg ctctccacag      180

gatccactgt gcctggtgac cctggacaga ggaggaaacg gatctggctc cccactgaga      240

gtggtgggcg ccctgagggg atacgagcac gcctttctgg aggccgtgag gagagcaaga      300

tggggacctc acggcctggc caccttcggc gtgtgcaccc ctagggatag acaggccgcc      360

ccattttccc tgaggcagct gcaggcatgg ctgggagagc caggaggccg gcgcctggtg      420

gtgctgcacc tggaggaggt gacctgggag ccaaccccca gcctgaagtt ccaggagcca      480

ccacctggag gagcaggacc cctggagctg gccatgctgg tgctgtaccc tggaccagga      540

ccagaggtga ccgtgaccgg agcaggcctg cctggcaccc agtctctgtg ccagtccagg      600

gataccagat acctggtgct ggccgtggac cacccagagg gagcatggcg ctcccctggc      660

ctgaccctga ccctgcagcc taggagagat ggagcaccac tgagcaccgc acagctgcag      720

gagctgctgt tcggacctga cccacgctgt tttaccagga tgacccccgc cctgctgctg      780

ctgccaggac ctgcaccagc accactgcct gccagaggcc tgctggatca ggtgcccctg      840

ccaccaccta gacctagcca ggagcaggca cctgaggagc cacggtccag cgccgaccct      900

ttcctggaaa ccctgaccag gctggtgcgc gccctgaggg gaccaccagc acaggcctct      960

ccagccagac tggccctgga tccaggcgcc ctggccggat ttcctcaggg cctggtgaac     1020

ctgtccgatc cagcagcaca ggagcggctg ctgaatggag gcgacgagcc actgctgctg     1080

ctgctgctgc ctccagcaac cccaaccgcc gccgcagcag cagcaggcga ccctgccccc     1140

cctcggggcc cagcctctgc cccctgggcc gccggcctgg cccggcgcgt ggccgccgag     1200

ctgcaggccg ccgccgccga gctgagaggc ctgccaggcc tgccacccgc cgccaccccc     1260

ctgctggccc ggctgctggc cctgtgccct ggcgactccg gcgatagcgg cgacccagga     1320

gcacctccag gaggaccagg aggccctctg cgcgccctgc tgctgctgaa ggccctgcag     1380

ggcctgaggg ccgagtggcg gggccgcgag caggccggcc ctgccagagc acagcggtct     1440

gccggagcag gagcagcaga tggcccatgt gcactgaggg agctgagcgt ggacctgagg     1500

gcagagaggt ctgtgctgat ccccgaaacc taccaggcca acaattgcca gggagcatgt     1560

ggatggccac agtccgacag aaacccccgg tacggcaatc acgtggtgct gctgctgaag     1620

atgcaggcaa ggggagccgc cctggccagg cccccttgct gcgtgccaac cgcatacgca     1680

ggcaagctgc tgatcagcct gtctgaagaa agaatctctg ctcatcacgt ccccaatatg     1740

gtcgccactg aatgcggttg tcggtga                                         1767


<210>  6
<211>  1728
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence encoding an exemplary chimeric feline MIS

<400>  6
atgcctgggc tgctgtctcc acccgctctc gtcctgtccg tgatgggggc tctcctgatg       60

gctggcgacc ctggggaaga agtgtcctct acccccgccc tgcctggagg accagcaacc      120

ggcaccggag gcctgatctt ccacccagac tgggattggc agccacctgg cagcccccag      180

gaccctctgt gcctggtgac cctggatagg ggaggaaacg gatctggcag cccactgagg      240

gtggtgggcg ccctgagagg atacgagcac gccttcctgg aggccgtgag gagagcaaga      300

tggggacctc acggcctggc caccttcggc gtgtgcaccc cacgggaccg ccaggcagca      360

cctttctccc tgagacagct gcaggcatgg ctgggagagc caggaggccg gcgcctggtg      420

gtgctgcacc tggaggaggt gacctgggag ccaacccctt ctctgaagtt ccaggagcca      480

ccacctggag gagcaggacc cctggagctg gcaatgctgg tgctgtaccc aggaccagga      540

cctgaggtga ccgtgaccgg agcaggcctg cctggcaccc agagcctgtg ccagtccagg      600

gacaccagat acctggtgct ggcagtggat cacccagagg gagcatggag atcccccggc      660

ctgaccctga ccctgcagcc aaggagagac ggagcacctc tgtctaccgc acagctgcag      720

gagctgctgt tcggaccaga tccaaggtgt ttcaccagga tgacccccgc cctgctgctg      780

ctgcctggac cagcaccagc acctctgcca gcaaggggcc tgctggacca ggtgccactg      840

ccaccacctc ggccctctca ggagcaggca ccagaggagc cacgcagctc cgccgatccc      900

ttcctggaaa ccctgaccag actggtgcgg gccctgaggg gaccaccagc acaggccagc      960

cctgcccggc tggccctgga cccaggcgcc ctggccggct tcccacaggg cctggtgaac     1020

ctgtccgacc cagcagcaca ggagcgcctg ctgaacggag gcgatgagcc actgctgctg     1080

ctgctgcctc caccaaccgc agcagcagga cctccagcac cacctccaag gcctgccagc     1140

gccccatggg ccgccggcct ggccctgcgg gtggccgccg agctgcgcgc cgccgccgcc     1200

gagctgcggg gcctgcctgg cctgccccct gccaccgccc cactgctgga gcgcctgctg     1260

gccctgtgcc ccggcggcag cggcggctcc ggcggctctg gcgaccctct gagggccctg     1320

ctgctgctga aggccctgca gggcctgaga gcagagtgga ggggaagaga gcggggcggc     1380

ccacccaggg cccagagaag cgccggagca ggagcagcag acggaccttg tgccctgaga     1440

gagctgtctg tggatctgag ggcagagcgc agcgtgctga tcccagaaac ctaccaggcc     1500

aacaactgcc agggagcatg tggatggcct cagtccgata ggaacccaag atacggcaac     1560

cacgtggtgc tgctgctgaa gatgcaggca aggggagccg ccctggccag acctccatgc     1620

tgcgtgccaa ccgcatacgc aggcaagctg ctgatctccc tgtctgagga aagaatctct     1680

gctcatcacg tcccaaacat ggtcgcaacc gagtgtggct gtcgctga                  1728


<210>  7
<211>  554
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary recombinant modified human MIS (LRhMIS) protein

<400>  7

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Arg Ala Glu Glu Pro Ala Val Gly Thr Ser Gly Leu Ile 
            20                  25                  30          


Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly Ser Pro Gln Glu Pro Leu 
        35                  40                  45              


Cys Leu Val Ala Leu Gly Gly Asp Ser Asn Gly Ser Ser Ser Pro Leu 
    50                  55                  60                  


Arg Val Val Gly Ala Leu Ser Ala Tyr Glu Gln Ala Phe Leu Gly Ala 
65                  70                  75                  80  


Val Gln Arg Ala Arg Trp Gly Pro Arg Asp Leu Ala Thr Phe Gly Val 
                85                  90                  95      


Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu Pro Ser Leu Arg Arg Leu 
            100                 105                 110         


Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln Arg Leu Val Val Leu His 
        115                 120                 125             


Leu Glu Glu Val Thr Trp Glu Pro Thr Pro Ser Leu Arg Phe Gln Glu 
    130                 135                 140                 


Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu Leu Ala Leu Leu Val Leu 
145                 150                 155                 160 


Tyr Pro Gly Pro Gly Pro Glu Val Thr Val Thr Arg Ala Gly Leu Pro 
                165                 170                 175     


Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp Thr Arg Tyr Leu Val Leu 
            180                 185                 190         


Ala Val Asp Arg Pro Ala Gly Ala Trp Arg Gly Ser Gly Leu Ala Leu 
        195                 200                 205             


Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg Leu Ser Thr Ala Arg Leu 
    210                 215                 220                 


Gln Ala Leu Leu Phe Gly Asp Asp His Arg Cys Phe Thr Arg Met Thr 
225                 230                 235                 240 


Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu Pro Ala Pro Leu Pro Ala 
                245                 250                 255     


His Gly Gln Leu Asp Thr Val Pro Phe Pro Pro Pro Arg Pro Ser Ala 
            260                 265                 270         


Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp Pro Phe Leu Glu Thr Leu 
        275                 280                 285             


Thr Arg Leu Val Arg Ala Leu Arg Val Pro Pro Ala Arg Ala Ser Ala 
    290                 295                 300                 


Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu Ala Gly Phe Pro Gln Gly 
305                 310                 315                 320 


Leu Val Asn Leu Ser Asp Pro Ala Ala Leu Glu Arg Leu Leu Asp Gly 
                325                 330                 335     


Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro Thr Ala Ala Thr Thr Gly 
            340                 345                 350         


Asp Pro Ala Pro Leu His Asp Pro Thr Ser Ala Pro Trp Ala Thr Ala 
        355                 360                 365             


Leu Ala Arg Arg Val Ala Ala Glu Leu Gln Ala Ala Ala Ala Glu Leu 
    370                 375                 380                 


Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr Ala Pro Leu Leu Ala Arg 
385                 390                 395                 400 


Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly Gly Leu Gly Asp Pro Leu 
                405                 410                 415     


Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Val Glu Trp 
            420                 425                 430         


Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg Ala Arg Arg Ser Ala Gly 
        435                 440                 445             


Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser Val Asp 
    450                 455                 460                 


Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln Ala Asn 
465                 470                 475                 480 


Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg Asn Pro Arg 
                485                 490                 495     


Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Val Arg Gly Ala 
            500                 505                 510         


Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Ala Gly Lys 
        515                 520                 525             


Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His Val Pro 
    530                 535                 540                 


Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 


<210>  8
<211>  1680
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid encoding an exemplary recombinant modified human 
       (hMIS) protein of SEQ ID NO: 7

<400>  8
atgaagtggg tgagcttcat cagcctgctg ttcctgttca gcagcgctta ctcccgcggt       60

gtgttccgcc gcagagcaga ggagccagct gtgggcacca gtggcctcat cttccgagaa      120

gacttggact ggcctccagg cagcccacaa gagcctctgt gcctggtggc actgggcggg      180

gacagcaatg gcagcagctc ccccctgcgg gtggtggggg ctctaagcgc ctatgagcag      240

gccttcctgg gggccgtgca gagggcccgc tggggccccc gagacctggc caccttcggg      300

gtctgcaaca ccggtgacag gcaggctgcc ttgccctctc tacggcggct gggggcctgg      360

ctgcgggacc ctggggggca gcgcctggtg gtcctacacc tggaggaagt gacctgggag      420

ccaacaccct cgctgaggtt ccaggagccc ccgcctggag gagctggccc cccagagctg      480

gcgctgctgg tgctgtaccc tgggcctggc cctgaggtca ctgtgacgag ggctgggctg      540

ccgggtgccc agagcctctg cccctcccga gacacccgct acctggtgtt agcggtggac      600

cgccctgcgg gggcctggcg cggctccggg ctggccttga ccctgcagcc ccgcggagag      660

gactcccggc tgagtaccgc ccggctgcag gcactgctgt tcggcgacga ccaccgctgc      720

ttcacacgga tgaccccggc cctgctcctg ctgccgcggt ccgagcccgc gccgctgcct      780

gcgcacggcc agctggacac cgtgcccttc ccgccgccca ggccatccgc ggaactcgag      840

gagtcgccac ccagcgcaga ccccttcctg gagacgctca cgcgcctggt gcgggcgctg      900

cgggtccccc cggcccgggc ctccgcgccg cgcctggccc tggatccgga cgcgctggcc      960

ggcttcccgc agggcctagt caacctgtcg gaccccgcgg cgctggagcg cctactcgac     1020

ggcgaggagc cgctgctgct gctgctgagg cccactgcgg ccaccaccgg ggatcctgcg     1080

cccctgcacg accccacgtc ggcgccgtgg gccacggccc tggcgcgccg cgtggctgct     1140

gaactgcaag cggcggctgc cgagctgcga agcctcccgg gtctgcctcc ggccacagcc     1200

ccgctgctgg cgcgcctgct cgcgctctgc ccaggtggcc ccggcggcct cggcgatccc     1260

ctgcgagcgc tgctgctcct gaaggcgctg cagggcctgc gcgtggagtg gcgcgggcgg     1320

gatccgcgcg ggccgggtcg ggcacggcgc agcgcggggg ccaccgccgc cgacgggccg     1380

tgcgcgctgc gcgagctcag cgtagacctc cgcgccgagc gctccgtact catccccgag     1440

acctaccagg ccaacaattg ccagggcgtg tgcggctggc ctcagtccga ccgcaacccg     1500

cgctacggca accacgtggt gctgctgctg aagatgcagg cccgtggggc cgccctggcg     1560

cgcccaccct gctgcgtgcc caccgcctac gcgggcaagc tgctcatcag cctgtcggag     1620

gagcgcatca gcgcgcacca cgtgcccaac atggtggcca ccgagtgtgg ctgccggtga     1680


<210>  9
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary leader sequence

<400>  9

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  10
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary leader sequence

<400>  10

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  11
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary leader sequence

<400>  11

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary leader sequence

<400>  12

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary leader sequence

<400>  13

Met Lys Trp Val Ser Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  14
<211>  585
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary LR-fcMISv2 amino acid sequence

<400>  14

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Leu Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Asp Pro Gly Glu Glu Val Ser Ser Thr Pro Ala Leu Pro 
            20                  25                  30          


Gly Gly Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe His Pro Asp Trp 
        35                  40                  45              


Asp Trp Gln Pro Pro Gly Ser Pro Gln Asp Pro Leu Cys Leu Val Thr 
    50                  55                  60                  


Leu Asp Arg Gly Gly Asn Gly Ser Gly Ser Pro Leu Arg Val Val Gly 
65                  70                  75                  80  


Ala Leu Arg Gly Tyr Glu His Ala Phe Leu Glu Ala Val Arg Arg Ala 
                85                  90                  95      


Arg Trp Gly Pro His Gly Leu Ala Thr Phe Gly Val Cys Thr Pro Arg 
            100                 105                 110         


Asp Arg Gln Ala Ala Pro Phe Ser Leu Arg Gln Leu Gln Ala Trp Leu 
        115                 120                 125             


Gly Glu Pro Gly Gly Arg Arg Leu Val Val Leu His Leu Glu Glu Val 
    130                 135                 140                 


Thr Trp Glu Pro Thr Pro Ser Leu Lys Phe Gln Glu Pro Pro Pro Gly 
145                 150                 155                 160 


Gly Ala Gly Pro Leu Glu Leu Ala Met Leu Val Leu Tyr Pro Gly Pro 
                165                 170                 175     


Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro Gly Thr Gln Ser 
            180                 185                 190         


Leu Cys Gln Ser Arg Asp Thr Arg Tyr Leu Val Leu Ala Val Asp His 
        195                 200                 205             


Pro Glu Gly Ala Trp Arg Ser Pro Gly Leu Thr Leu Thr Leu Gln Pro 
    210                 215                 220                 


Arg Arg Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Phe Gly Pro Asp Pro Arg Cys Phe Thr Arg Met Thr Pro Ala Leu Leu 
                245                 250                 255     


Leu Leu Pro Gly Pro Ala Pro Ala Pro Leu Pro Ala Arg Gly Leu Leu 
            260                 265                 270         


Asp Gln Val Pro Leu Pro Pro Pro Arg Pro Ser Gln Glu Gln Ala Pro 
        275                 280                 285             


Glu Glu Pro Arg Ser Ser Ala Asp Pro Phe Leu Glu Thr Leu Thr Arg 
    290                 295                 300                 


Leu Val Arg Ala Leu Arg Gly Pro Pro Ala Gln Ala Ser Pro Ala Arg 
305                 310                 315                 320 


Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln Gly Leu Val 
                325                 330                 335     


Asn Leu Ser Asp Pro Ala Ala Gln Glu Arg Leu Leu Asn Gly Gly Asp 
            340                 345                 350         


Glu Pro Leu Leu Leu Leu Leu Leu Pro Pro Ala Thr Pro Thr Ala Ala 
        355                 360                 365             


Ala Ala Ala Ala Gly Asp Pro Ala Pro Pro Arg Gly Pro Ala Ser Ala 
    370                 375                 380                 


Pro Trp Ala Ala Gly Leu Ala Arg Arg Val Ala Ala Glu Leu Gln Ala 
385                 390                 395                 400 


Ala Ala Ala Glu Leu Arg Gly Leu Pro Gly Leu Pro Pro Ala Ala Thr 
                405                 410                 415     


Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Asp Ser Gly Asp 
            420                 425                 430         


Ser Gly Asp Pro Gly Ala Pro Pro Gly Gly Pro Gly Gly Pro Leu Arg 
        435                 440                 445             


Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala Glu Trp Arg 
    450                 455                 460                 


Gly Arg Glu Gln Ala Gly Pro Ala Arg Ala Arg Arg Ser Ala Gly Ala 
465                 470                 475                 480 


Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser Val Asp Leu 
                485                 490                 495     


Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln Ala Asn Asn 
            500                 505                 510         


Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn Pro Arg Tyr 
        515                 520                 525             


Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg Gly Ala Ala 
    530                 535                 540                 


Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Ala Gly Lys Leu 
545                 550                 555                 560 


Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His Val Pro Asn 
                565                 570                 575     


Met Val Ala Thr Glu Cys Gly Cys Arg 
            580                 585 


<210>  15
<211>  568
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary LR-clMIS

<400>  15

Met Lys Trp Val Thr Phe Ile Ser Leu Phe Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Glu Ala Pro Gly Gly Glu Val Ser Gly Thr Pro Ala Ser Pro 
            20                  25                  30          


Gly Glu Pro Ala Thr Gly Thr Gly Gly Leu Leu Phe Gln Pro Asp Trp 
        35                  40                  45              


Asp Trp Pro Pro Ser Ala Pro Gln Asp Pro Leu Cys Leu Val Thr Leu 
    50                  55                  60                  


Asp Lys Gly Gly Asn Gly Ser Ser Pro Pro Leu Arg Val Ala Gly Ala 
65                  70                  75                  80  


Leu Arg Gly Tyr Glu His Thr Phe Leu Glu Ala Val Arg Arg Ala Arg 
                85                  90                  95      


Trp Gly Pro His Asp Leu Ala Thr Phe Gly Ala Cys Ala Ala Ser Asp 
            100                 105                 110         


Gly Arg Thr Thr Gln Leu Ser Leu Arg Gln Leu Gln Ala Trp Leu Gly 
        115                 120                 125             


Ala Pro Gly Gly Arg Arg Leu Val Val Leu His Leu Glu Glu Val Thr 
    130                 135                 140                 


Trp Glu Pro Ala Leu Ser Leu Lys Phe Gln Glu Pro Pro Pro Gly Gly 
145                 150                 155                 160 


Ala Ser Pro Leu Glu Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly 
                165                 170                 175     


Pro Glu Val Ala Val Thr Gly Ala Gly Leu Pro Gly Thr Gln Asn Leu 
            180                 185                 190         


Cys Arg Ser Arg Asn Thr Arg Tyr Leu Val Leu Ala Leu Asp His Pro 
        195                 200                 205             


Val Gly Ala Trp His Ser Pro Arg Val Thr Leu Thr Val His Ala Arg 
    210                 215                 220                 


Gly Asp Gly Ala Pro Leu Ser Thr Pro Gln Leu Gln Glu Leu Leu Phe 
225                 230                 235                 240 


Gly Pro Asp Ala Arg Cys Phe Thr Arg Met Thr Pro Ala Leu Leu Val 
                245                 250                 255     


Leu Arg Leu Pro Gly Pro Thr Ala Val Pro Ala Arg Gly Leu Leu Asp 
            260                 265                 270         


Leu Val Pro Phe Pro Pro Pro Arg Pro Ser Arg Glu Pro Ala Glu Pro 
        275                 280                 285             


Pro Pro Ser Ala Asp Pro Phe Leu Glu Thr Leu Thr Arg Leu Val Arg 
    290                 295                 300                 


Ala Leu Arg Gly Pro Pro Thr Pro Ala Ser Pro Pro Arg Leu Ala Leu 
305                 310                 315                 320 


Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln Gly Leu Leu Asn Leu Ser 
                325                 330                 335     


Asp Pro Ala Thr Gln Glu Arg Leu Leu Gly Gly Glu Glu Pro Leu Leu 
            340                 345                 350         


Leu Leu Leu Pro Pro Pro Thr Ala Ala Ala Gly Pro Pro Ala Pro Pro 
        355                 360                 365             


Pro Arg Pro Ala Ser Ala Pro Trp Ala Ala Gly Leu Ala Leu Arg Val 
    370                 375                 380                 


Ala Ala Glu Leu Arg Ala Ala Ala Ala Glu Leu Arg Gly Leu Pro Gly 
385                 390                 395                 400 


Leu Pro Pro Ala Ala Ala Pro Leu Leu Glu Arg Leu Leu Ala Leu Cys 
                405                 410                 415     


Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Asp Pro Leu Arg Ala 
            420                 425                 430         


Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala Glu Trp Arg Gly 
        435                 440                 445             


Arg Glu Arg Gly Gly Pro Pro Arg Ala Arg Arg Ser Ala Gly Ala Gly 
    450                 455                 460                 


Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser Val Asp Leu Arg 
465                 470                 475                 480 


Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln Ala Asn Asn Cys 
                485                 490                 495     


Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn Pro Arg Tyr Gly 
            500                 505                 510         


Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg Gly Ala Ala Leu 
        515                 520                 525             


Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Gly Gly Lys Leu Leu 
    530                 535                 540                 


Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His Val Pro Asn Met 
545                 550                 555                 560 


Val Ala Thr Glu Cys Gly Cys Arg 
                565             


<210>  16
<211>  1713
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Exemplary nucleic acid encoding LR-clMIS

<400>  16
atgaagtggg tgaccttcat cagcctattc ttcctgttca gcagcgccta cagcgaagca       60

cctggcggcg aggtttccgg aacacccgct tcacctggcg aaccagcaac tggaacagga      120

ggcctactat tccagccaga ctgggattgg cccccttcag ccccccaaga ccctctatgc      180

ctagtaaccc tagataaagg aggcaacggc tcttccccac ccctacgagt ggcaggagcc      240

ctacgaggct acgaacacac attcctagag gccgtacgac gagctcgatg gggaccccac      300

gacctagcaa cctttggcgc ctgcgccgct tctgatggac gaacaaccca gctatcccta      360

cgacagctac aagcttggct aggagcacct ggaggccgac gactagtggt actacaccta      420

gaagaggtga catgggaacc cgccctatct ctaaagtttc aggagcctcc accaggagga      480

gcctcccctc tagaactagc tctactagta ctataccctg gaccaggacc agaggtggca      540

gtaaccggag ctggcctacc aggcactcaa aacctatgcc gatctcgaaa cacccgatac      600

ctcgtgctcg ctctagacca ccctgtagga gcatggcact caccacgagt gaccctaact      660

gtacacgcac gaggagacgg cgccccacta tctacccccc agctacaaga gctactattc      720

ggccccgatg cccgatgctt tactcgaatg acacctgctc tactagtgct acgactacct      780

ggcccaactg ctgtacctgc acgaggacta ctagacctag tgccattccc tccaccccga      840

ccttcccgag aaccagcaga gcctccaccc tcagccgatc catttctaga aacactaacc      900

cgactagtgc gagccctacg aggacctcca acacccgctt ccccccctcg actagcacta      960

gaccccggag ctctagcagg cttccctcag ggactactaa acctatcaga tccagctact     1020

caagagcgac tactaggagg cgaagagccc ctactactac tactaccacc ccctacagca     1080

gccgctggac caccagctcc tccaccccga cccgcctccg ctccttgggc agccggacta     1140

gcactacgag tagctgcaga actacgagcc gctgcagccg agctacgagg actaccaggc     1200

ctacctccag ctgcagcccc cctactagaa cgactactag ccctatgccc tggaggatcc     1260

ggaggatcag gaggatctgg cgacccacta cgagccctac tactactaaa agctctacag     1320

ggcctacgag cagaatggcg aggacgagag agaggaggac cacctcgagc acggcgatct     1380

gcaggagcag gagctgcaga cggaccttgc gcactacgag agctatcagt ggatctacga     1440

gccgaacgat ctgtactaat cccagagact taccaggcca acaactgcca aggagcttgc     1500

ggctggccac agtccgatcg aaacccccga tatggcaacc acgtggtact actactaaaa     1560

atgcaagcac gaggagccgc tctagcccga ccaccatgct gcgtgcctac cgcatatgga     1620

ggcaagctac taatttcact atctgaagaa cggatctccg cacatcacgt acctaatatg     1680

gtagctactg agtgtggttg tagatgaggt acc                                  1713


<210>  17
<211>  1725
<212>  DNA
<213>  Canis lupus familiaris

<400>  17
atgggcgcat tagcactttg gcctttagcc ttagcactat caggaatggg accactactg       60

ggagcagaag cacctggcgg cgaggtttcc ggaacacccg cttcacctgg cgaaccagca      120

actggaacag gaggcctact attccagcca gactgggatt ggcccccttc agccccccaa      180

gaccctctat gcctagtaac cctagataaa ggaggcaacg gctcttcccc acccctacga      240

gtggcaggag ccctacgagg ctacgaacac acattcctag aggccgtacg acgagctcga      300

tggggacccc acgacctagc aacctttggc gcctgcgccg cttctgatgg acgaacaacc      360

cagctatccc tacgacagct acaagcttgg ctaggagcac ctggaggccg acgactagtg      420

gtactacacc tagaagaggt gacatgggaa cccgccctat ctctaaagtt tcaggagcct      480

ccaccaggag gagcctcccc tctagaacta gctctactag tactataccc tggaccagga      540

ccagaggtgg cagtaaccgg agctggccta ccaggcactc aaaacctatg ccgatctcga      600

aacacccgat acctcgtgct cgctctagac caccctgtag gagcatggca ctcaccacga      660

gtgaccctaa ctgtacacgc acgaggagac ggcgccccac tatctacccc ccagctacaa      720

gagctactat tcggccccga tgcccgatgc tttactcgaa tgacacctgc tctactagtg      780

ctacgactac ctggcccaac tgctgtacct gcacgaggac tactagacct agtgccattc      840

cctccacccc gaccttcccg agaaccagca gagcctccac cctcagccga tccatttcta      900

gaaacactaa cccgactagt gcgagcccta cgaggacctc caacacccgc ttccccccct      960

cgactagcac tagaccccgg agctctagca ggcttccctc agggactact aaacctatca     1020

gatccagcta ctcaagagcg actactagga ggcgaagagc ccctactact actactacca     1080

ccccctacag cagccgctgg accaccagct cctccacccc gacccgcctc cgctccttgg     1140

gcagccggac tagcactacg agtagctgca gaactacgag ccgctgcagc cgagctacga     1200

ggactaccag gcctacctcc agctgcagcc cccctactag aacgactact agccctatgc     1260

cctggaggat ccggaggatc aggaggatct ggcgacccac tacgagccct actactacta     1320

aaagctctac agggcctacg agcagaatgg cgaggacgag agagaggagg accacctcga     1380

gcacaacgat ctgcaggagc aggagctgca gacggacctt gcgcactacg agagctatca     1440

gtggatctac gagccgaacg atctgtacta atcccagaga cttaccaggc caacaactgc     1500

caaggagctt gcggctggcc acagtccgat cgaaaccccc gatatggcaa ccacgtggta     1560

ctactactaa aaatgcaagc acgaggagcc gctctagccc gaccaccatg ctgcgtgcct     1620

accgcatatg gaggcaagct actaatttca ctatctgaag aacggatctc cgcacatcac     1680

gtacctaata tggtagctac tgagtgtggt tgtagatgag gtacc                     1725


<210>  18
<211>  589
<212>  PRT
<213>  Felis silvestris catus

<400>  18

Met Pro Gly Leu Leu Ser Pro Pro Ala Leu Val Leu Ser Val Met Gly 
1               5                   10                  15      


Ala Leu Leu Met Ala Gly Asp Pro Gly Glu Glu Val Ser Ser Thr Pro 
            20                  25                  30          


Ala Leu Pro Gly Gly Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe His 
        35                  40                  45              


Pro Asp Trp Asp Trp Gln Pro Pro Gly Ser Pro Gln Asp Pro Leu Cys 
    50                  55                  60                  


Leu Val Thr Leu Asp Arg Gly Gly Asn Gly Ser Gly Ser Pro Leu Arg 
65                  70                  75                  80  


Val Val Gly Ala Leu Arg Gly Tyr Glu His Ala Phe Leu Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Arg Trp Gly Pro His Gly Leu Ala Thr Phe Gly Val Cys 
            100                 105                 110         


Thr Pro Arg Asp Arg Gln Ala Ala Pro Phe Ser Leu Arg Gln Leu Gln 
        115                 120                 125             


Ala Trp Leu Gly Glu Pro Gly Gly Arg Arg Leu Val Val Leu His Leu 
    130                 135                 140                 


Glu Glu Val Thr Trp Glu Pro Thr Pro Ser Leu Lys Phe Gln Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Gly Ala Gly Pro Leu Glu Leu Ala Met Leu Val Leu Tyr 
                165                 170                 175     


Pro Gly Pro Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro Gly 
            180                 185                 190         


Thr Gln Ser Leu Cys Gln Ser Arg Asp Thr Arg Tyr Leu Val Leu Ala 
        195                 200                 205             


Val Asp His Pro Glu Gly Ala Trp Arg Ser Pro Gly Leu Thr Leu Thr 
    210                 215                 220                 


Leu Gln Pro Arg Arg Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu Gln 
225                 230                 235                 240 


Glu Leu Leu Phe Gly Pro Asp Pro Arg Cys Phe Thr Arg Met Thr Pro 
                245                 250                 255     


Ala Leu Leu Leu Leu Pro Gly Pro Ala Pro Ala Pro Leu Pro Ala Arg 
            260                 265                 270         


Gly Leu Leu Asp Gln Val Pro Leu Pro Pro Pro Arg Pro Ser Gln Glu 
        275                 280                 285             


Gln Ala Pro Glu Glu Pro Arg Ser Ser Ala Asp Pro Phe Leu Glu Thr 
    290                 295                 300                 


Leu Thr Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Ala Gln Ala Ser 
305                 310                 315                 320 


Pro Ala Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln 
                325                 330                 335     


Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Gln Glu Arg Leu Leu Asn 
            340                 345                 350         


Gly Gly Asp Glu Pro Leu Leu Leu Leu Leu Leu Pro Pro Ala Thr Pro 
        355                 360                 365             


Thr Ala Ala Ala Ala Ala Ala Ala Gly Asp Pro Ala Pro Pro Arg Gly 
    370                 375                 380                 


Pro Ala Ser Ala Pro Trp Ala Ala Gly Leu Ala Arg Arg Val Ala Ala 
385                 390                 395                 400 


Glu Leu Gln Ala Ala Ala Ala Glu Leu Arg Gly Leu Pro Gly Leu Pro 
                405                 410                 415     


Pro Ala Ala Thr Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly 
            420                 425                 430         


Asp Ser Gly Asp Ser Gly Asp Pro Gly Ala Pro Pro Gly Gly Pro Gly 
        435                 440                 445             


Gly Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg 
    450                 455                 460                 


Ala Glu Trp Arg Gly Arg Glu Gln Gly Gly Pro Ala Arg Ala Gln Arg 
465                 470                 475                 480 


Ser Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
                485                 490                 495     


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            500                 505                 510         


Gln Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg 
        515                 520                 525             


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    530                 535                 540                 


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
545                 550                 555                 560 


Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                565                 570                 575     


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            580                 585                 


<210>  19
<211>  3423
<212>  DNA
<213>  Felis silvestris catus

<400>  19
cggtgtccct gtgtcctccc aggatgccgg tgggtgaagg acagacccag gcagtcagca       60

gcgggtctgg gctctcttct gcggccgctc accctccttg gggtctccag ccaaatggct      120

gtgcttctgc agctccaggg tgccaagagg cagtgtgagc gagcacttgg ggagccccag      180

cttcgctggg agaccaccct ctggccaagc ccacgtgcac ccagcggtct gaacaccaag      240

atctccggtc cccatcagag ccgggtgccg gaggcctcca gggcgcctgc ccccctgccc      300

ccattccaga gctgttgatc gccggtctgg ttcccactcc ctcctgcaga gggggaaaac      360

ctcatcaagg acagtcgttg gaccaactgg gcacgggcgg cactctgtat cacgggtagg      420

aagataggcg gtcaggctgg aacagaagag gctttgagag gctcctctgc ctgcccaggc      480

ccacggcggg gcaccagacg ttggccccca aggtcacacc ccagaaggag ataggggctt      540

tgctcctgca caaacatccc ggtctcctcc atataagcca gagccacacg gcccctcaca      600

gcagccagga tgcctggtct gctctctccg ccggccctgg tgctgtcggt gatgggggct      660

ctgctgatgg ccggggaccc tggggaagag gtctccagca ccccggccct gcctggaggg      720

ccagccacag gcaccggggg tctcatcttc cacccggatt gggactggca gcccccgggc      780

agtccccaag accccctgtg cctggtgacg ctggacaggg gtggtaacgg gagcggctcc      840

ccgcttcggg tggtgggggc gctgagaggc tacgagcacg ccttcctcga ggctgtgcgg      900

cgggcccgct ggggtcccca cggcctggcc accttcggag tttgcacccc cagggacagg      960

caggccgccc cgttctctct gcggcagctg caggcgtggc tgggggagcc cggggggcgg     1020

cggctggtgg tgctgcacct ggaggaaggt acgtagggag ggggccacgg cctggggggg     1080

tgccacgctg ccaccactct ttccagaccg ggtcctgccg gagcccaact ctagacgcat     1140

cttggcctcc ggggaaggct gaggctgagg gcccaggaag tgggggccct tcgtgtctgg     1200

gggctgcaaa ccccccgatg ctttgcttcc aagcccaccc ctcctgcagc cctcctggga     1260

ggtgtttgcc gcccccccca ccccacgaag gagcagaagg gagtccgggc agagccatgc     1320

tccgcccaca cccctcctcc aagggtggtt agtgtgcggc ctgttcccgg acgctgctgg     1380

aggaaatggt ttcccagggg accctatggg ctcccccgct aaggagagcc ccagacagag     1440

accccatggg gtgctccagg ctcctcgcat tggggcaagg ccctgcaccc gatgtctggg     1500

cgtcaagcct ctcccggtac gggtgggggc tctccctgca ggactgcaag acgggcttcg     1560

gggaggtgct ggggcctcgg tgactcaggt gttgcccctt ccctatttgt ccctcctggc     1620

cacagtgaca tgggagccga caccctcact gaagttccag gagcccccgc ctggaggggc     1680

cggtccccta gagctggcga tgctggtgct gtaccccggc cctggccccg aggtcacggt     1740

cacaggggct gggctgccag gcacccaggt accggggtgt tgaaggcggt tagttctggg     1800

gcctccagga gccctccccc aacagaggag ggggaatggg gttttttaac tgtgctgaac     1860

agaaaggttc caagtccgct ggttggaacc ttgaaggggg gtgtcaaggg caatgggcag     1920

agcagggctg gtgtcctcgc cccccccccc ccacctggct aggctgagcc cccgtctcca     1980

cagagcctct gtcagtcccg ggacacccgc tacctggtgc tggcggtgga ccacccagaa     2040

ggggcctggc gcagccccgg gctcaccctg accctgcaac cccgcagaga cggtaggctc     2100

tccaagagag ggaccgggta agggtgggcg gcccgcggtc ctccgccccc gctcagccag     2160

gcccccgtgc tccgccacgc aggtgcgccc ctgagcaccg cccagctgca ggagctgctg     2220

ttcggccccg acccccgctg cttcacacgc atgaccccgg cgctgctcct gctgccgggg     2280

cccgcgcctg caccgctgcc cgcgcgtggc ctgctggacc aagtgcctct cccgccgccc     2340

aggtgtgcgc aggcccacgt tgggggtgtc gggaggggaa ccctgcacct gcccctaccg     2400

cccaactccg ccttccaggc cctcccagga gcaggcgcct gaggagccac ggtccagcgc     2460

cgaccccttc ctggagacgc tcacgcgcct ggtgcgcgcg ctgcgggggc ccccggccca     2520

ggcctcgccg gcgcgcctgg ccctggaccc cggcgcgctg gccggcttcc cgcagggcct     2580

ggtcaacctg tcggaccccg cggcgcagga gcgcctgctc aacggcggcg acgagccgct     2640

gctgctgctt ctgctgccac ccgccacgcc caccgccgcc gccgccgccg ccgccgggga     2700

ccccgcgccg ccgcgcggcc cggcgtccgc gccctgggcc gccggcctag cgcgtcgcgt     2760

ggccgccgag ctgcaggccg cggccgccga gctgcgaggg ctcccggggc tgccgccggc     2820

cgccacgccg ctgctggcgc gcctgctcgc gctgtgcccc ggggattcgg gggactcggg     2880

ggacccgggg gccccccccg gcggcccggg cggcccgctg cgcgcgctgc tgctgctcaa     2940

ggcgctgcag ggtctgcgcg cggagtggcg cgggcgcgag cagggcggac cggcgcgggc     3000

acagcgcagc gcgggggccg gggcggccga cgggccgtgc gcgctgcgcg agctgagcgt     3060

ggacctgcgc gccgagcgct ccgtgctcat cccggagacg taccaggcca acaactgcca     3120

gggcgcgtgc ggctggccgc agtccgaccg caacccgcgc tacggcaacc acgtggtgct     3180

gctgctcaag atgcaggccc gcggcgccgc cctggcgcgc ccgccctgct gcgtgcccac     3240

ggcctacgcg ggcaagctcc tcatcagcct gtcggaggag cgcatcagcg cgcaccacgt     3300

gcccaacatg gtggccaccg agtgcggctg ccggtgagcc ccgcaccgtg ccccccgagt     3360

ggcgtccccg cccgtattta ttcggacccc catcatcgcc ccaataaaga ccagcaagca     3420

cag                                                                   3423


<210>  20
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary LR-fcMIS-2 amino acid sequence

<400>  20

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Leu Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gly Asp Pro Gly Glu Glu Val Ser Ser Thr Pro Ala Leu Pro 
            20                  25                  30          


Gly Gly Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe His Pro Asp Trp 
        35                  40                  45              


Asp Trp Gln Pro Pro Gly Ser Pro Gln Asp Pro Leu Cys Leu Val Thr 
    50                  55                  60                  


Leu Asp Arg Gly Gly Asn Gly Ser Gly Ser Pro Leu Arg Val Val Gly 
65                  70                  75                  80  


Ala Leu Arg Gly Tyr Glu His Ala Phe Leu Glu Ala Val Arg Arg Ala 
                85                  90                  95      


Arg Trp Gly Pro His Gly Leu Ala Thr Phe Gly Val Cys Thr Pro Arg 
            100                 105                 110         


Asp Arg Gln Ala Ala Pro Phe Ser Leu Arg Gln Leu Gln Ala Trp Leu 
        115                 120                 125             


Gly Glu Pro Gly Gly Arg Arg Leu Val Val Leu His Leu Glu Glu Val 
    130                 135                 140                 


Thr Trp Glu Pro Thr Pro Ser Leu Lys Phe Gln Glu Pro Pro Pro Gly 
145                 150                 155                 160 


Gly Ala Gly Pro Leu Glu Leu Ala Met Leu Val Leu Tyr Pro Gly Pro 
                165                 170                 175     


Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro Gly Thr Gln Ser 
            180                 185                 190         


Leu Cys Gln Ser Arg Asp Thr Arg Tyr Leu Val Leu Ala Val Asp His 
        195                 200                 205             


Pro Glu Gly Ala Trp Arg Ser Pro Gly Leu Thr Leu Thr Leu Gln Pro 
    210                 215                 220                 


Arg Arg Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Phe Gly Pro Asp Pro Arg Cys Phe Thr Arg Met Thr Pro Ala Leu Leu 
                245                 250                 255     


Leu Leu Pro Gly Pro Ala Pro Ala Pro Leu Pro Ala Arg Gly Leu Leu 
            260                 265                 270         


Asp Gln Val Pro Leu Pro Pro Pro Arg Pro Ser Gln Glu Gln Ala Pro 
        275                 280                 285             


Glu Glu Pro Arg Ser Ser Ala Asp Pro Phe Leu Glu Thr Leu Thr Arg 
    290                 295                 300                 


Leu Val Arg Ala Leu Arg Gly Pro Pro Ala Gln Ala Ser Pro Ala Arg 
305                 310                 315                 320 


Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln Gly Leu Val 
                325                 330                 335     


Asn Leu Ser Asp Pro Ala Ala Gln Glu Arg Leu Leu Asn Gly Gly Asp 
            340                 345                 350         


Glu Pro Leu Leu Leu Leu Leu Leu Pro Pro Ala Thr Pro Thr Ala Ala 
        355                 360                 365             


Ala Ala Ala Ala Ala Gly Asp Pro Ala Pro Pro Arg Gly Pro Ala Ser 
    370                 375                 380                 


Ala Pro Trp Ala Ala Gly Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
385                 390                 395                 400 


Ala Ala Ala Ala Glu Leu Arg Gly Leu Pro Gly Leu Pro Pro Ala Ala 
                405                 410                 415     


Thr Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Asp Ser Gly 
            420                 425                 430         


Asp Ser Gly Asp Pro Gly Ala Pro Pro Gly Gly Pro Gly Gly Pro Leu 
        435                 440                 445             


Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala Glu Trp 
    450                 455                 460                 


Arg Gly Arg Glu Gln Gly Gly Pro Ala Arg Ala Arg Arg Ser Ala Gly 
465                 470                 475                 480 


Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser Val Asp 
                485                 490                 495     


Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln Ala Asn 
            500                 505                 510         


Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn Pro Arg 
        515                 520                 525             


Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg Gly Ala 
    530                 535                 540                 


Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Ala Gly Lys 
545                 550                 555                 560 


Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His Val Pro 
                565                 570                 575     


Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            580                 585     


