               Sequence listing

<110> JSC BIOCAD

<120> MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF THAT SPECIFICALLY BINDS TO GD2 (GANGLIOSIDE GD2), AND USE THEREOF

<150> RU2021107773
<151> 24-03-2021

<160> 100

<170> BiSSAP 1.3.6

<210> 1
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Kabat) of the heavy chain variable domain
      of antibodies 07-015, 07-016, 07-028 


<400> 1
Gly His Asn Met Asn 
1               5   

<210> 2
<211> 5
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Kabat) of the heavy chain variable domain
      of antibodies 07-006, 07-031, 07-041, 10-001,10-002, 10-003, 10-007, 10-008, 10-009

<400> 2
Gly Lys Asn Met Asn 
1               5   

<210> 3
<211> 17
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (Kabat) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 3
Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 4
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Kabat) of the heavy chain variable domain
      of antibodies 07-031, 10-001, 10-002, 10-003

<400> 4
Gly Met Ile Tyr 
1               

<210> 5
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Kabat) of the heavy chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 5
Gly Met Phe Tyr 
1               

<210> 6
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Kabat) of the heavy chain variable domain
      of antibody 07-006

<400> 6
Gly Met Tyr Tyr 
1               

<210> 7
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Kabat) of the heavy chain variable domain
      of antibodies 07-015, 07-016, 07-028

<400> 7
Gly Met Leu Tyr 
1               

<210> 8
<211> 16
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028,07-031, 10-001, 10-002, 10-003

<400> 8
Arg Ser Ser Arg Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      



<210> 9
<211> 16
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Kabat) of the light chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 9
Arg Ser Ser Gln Asn Leu Val His Arg Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      



<210> 10
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-031,10-001, 10-002, 10-003

<400> 10
Lys Val Ser Asn Arg Phe Gly 
1               5           

<210> 11
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (Kabat) of the light chain variable domain
      of antibodies 07-028, 07-041, 10-007, 10-008, 10-009

<400> 11
Lys Val Asn Asn Arg Phe Ser 
1               5           

<210> 12
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-031,07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 12
Gly Gln Ser Thr His Val Pro Pro Leu Thr 
1               5                   10  

<210> 13
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Kabat) of the light chain variable domain
      of antibody 07-028

<400> 13
Ser Gln Ser Thr His Val Pro Pro Leu Ser 
1               5                   10  

<210> 14
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain variable domain
      of antibody 07-006 

<400> 14
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 15
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain variable domain
      of antibodies 07-015, 07-016 и 07-028

<400> 15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly His 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 16
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain variable domain
      of antibodies 07-031, 10-001, 10-02, 10-003

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 17
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain variable domain
      of antibodies 07-041, 10-007, 10-08, 10-009

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Phe Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 18
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain variable domain
      of antibodies 07-006 и 07-016

<400> 18
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Arg Ser Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Gly Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210> 19
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain variable domain
      of antibodies 07-015, 07-031, 10-001, 10-002, 10-003

<400> 19
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Arg Ser Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile His Lys Val Ser Asn Arg Phe Gly Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210> 20
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain variable domain
      of antibody 07-028

<400> 20
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Arg Ser Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile His Lys Val Asn Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210> 21
<211> 113
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 21
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Gln Asn Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile His Lys Val Asn Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys 
    

<210> 22
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 07-006

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 23
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibodies 07-015,
      07-016, 07-028

<400> 23
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly His 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 24
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 07-031

<400> 24
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 25
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 07-041

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Phe Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 26
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 07-006 +
      YTE

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 27
<211> 443
<212> PRT
<213> Artificial sequence

<220> 
<223> amino acid sequence of the heavy chain of antibodies 07-015 +
      YTE, 07-016 + YTE и 07-028 + YTE

<400> 27
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly His 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 28
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 10-001

<400> 28
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 29
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 10-007

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Phe Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 30
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 07-006 +
      YTE + K322A

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 31
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibodies 07-015 +
      YTE + K322A, 07-016 + YTE + K322A and 07-028 + YTE + K322A

<400> 31
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly His 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 32
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 10-002

<400> 32
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 33
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 10-008

<400> 33
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Phe Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 34
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 07-006 +
      K322A

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 35
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibodies 07-015 +
      K322A, 07-016 + K322A and 07-028 + K322A

<400> 35
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly His 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 36
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 10-003

<400> 36
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Ile Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 37
<211> 443
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the heavy chain of antibody 10-009

<400> 37
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Lys 
            20                  25                  30          
Asn Met Asn Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Phe Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Gly Met Phe Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 
305                 310                 315                 320 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210> 38
<211> 220
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain of antibodies 07-006,
      07-016

<400> 38
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Arg Ser Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Gly Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 39
<211> 220
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain of antibodies 07-015,
      07-031, 10-001, 10-002, 10-003

<400> 39
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Arg Ser Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile His Lys Val Ser Asn Arg Phe Gly Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 40
<211> 220
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain of antibody 07-028

<400> 40
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Arg Ser Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile His Lys Val Asn Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Ser Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 41
<211> 220
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence of the light chain of antibodies 07-041,
      10-007, 10-008, 10-009

<400> 41
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys Arg Ser Ser Gln Asn Leu Val His Arg 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile His Lys Val Asn Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 

<210> 42
<211> 30
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR1 (Kabat) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009


<400> 42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr 
            20                  25                  30  

<210> 43
<211> 14
<212> PRT
<213> Artificial sequence

<220> 
<223> amino acid sequence FR2 (Kabat) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 43
Trp Val Arg Gln Asn Ile Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 44
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR3 (Kabat) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 44
Arg Val Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Val Ser 
            20                  25                  30          



<210> 45
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR4 (Kabat) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 45
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 46
<211> 23
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR1 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-15, 007-16, 07-028, 07-031,07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 46
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Arg Ala Ser Leu Ser Cys 
            20              

<210> 47
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR2 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-016, 07-028, 07-041,10-007, 10-008, 10-009

<400> 47
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His 
1               5                   10                  15  

<210> 48
<211> 15
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR2 (Kabat) of the light chain variable domain
      of antibodies 07-015, 07-031, 10-001, 10-002, 10-003

<400> 48
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile His 
1               5                   10                  15  

<210> 49
<211> 32
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR3 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028,07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 49
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys 
            20                  25                  30          



<210> 50
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence FR4 (Kabat) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028,07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 50
Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  

<210> 51
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Chothia) of the heavy chain variable domain
      of antibodies 07-006, 07-031, 07-041, 10-001,10-002, 10-003, 10-007, 10-008, 10-009

<400> 51
Gly Ser Ser Phe Thr Gly Lys 
1               5           

<210> 52
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Chothia) of the heavy chain variable domain
      of antibodies 07-015, 07-016, 07-028

<400> 52
Gly Ser Ser Phe Thr Gly His 
1               5           

<210> 53
<211> 6
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (Chothia) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028,07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 53
Asp Pro Phe Tyr Gly Gly 
1               5       

<210> 54
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Chothia) of the heavy chain variable domain
      of antibodies л 07-031, 10-001, 10-002, 10-003

<400> 54
Gly Met Ile Tyr 
1               

<210> 55
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Chothia) of the heavy chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 55
Gly Met Phe Tyr 
1               

<210> 56
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Chothia) of the heavy chain variable domain
      of antibody 07-006

<400> 56
Gly Met Tyr Tyr 
1               

<210> 57
<211> 4
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Chothia) of the heavy chain variable domain
      of antibodies 07-015, 07-016, 07-028

<400> 57
Gly Met Leu Tyr 
1               

<210> 58
<211> 13
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Chothia) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 10-001, 10-002, 10-003

<400> 58
Arg Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His 
1               5                   10              

<210> 59
<211> 13
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (Chothia) of the light chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 59
Gln Asn Leu Val His Arg Asn Gly Asn Thr Tyr Leu His 
1               5                   10              

<210> 60
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (Chothia) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-031, 10-001, 10-002, 10-003

<400> 60
Lys Val Ser Asn Arg Phe Gly 
1               5           

<210> 61
<211> 7
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (Chothia) of the light chain variable domain
      of antibodies 07-028, 07-041, 10-007, 10-008, 10-009

<400> 61
Lys Val Asn Asn Arg Phe Ser 
1               5           

<210> 62
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Chothia) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-031,07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 62
Gly Gln Ser Thr His Val Pro Pro Leu Thr 
1               5                   10  

<210> 63
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (Chothia) of the light chain variable domain
      of antibody 07-028

<400> 63
Ser Gln Ser Thr His Val Pro Pro Leu Ser 
1               5                   10  

<210> 64
<211> 8
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (IMGT) of the heavy chain variable domain
      of antibodies 07-006, 07-031, 07-041, 10-001,10-002, 10-003, 10-007, 10-008, 10-009


<400> 64
Gly Ser Ser Phe Thr Gly Lys Asn 
1               5               

<210> 65
<211> 8
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (IMGT) of the heavy chain variable domain
      of antibodies 07-015, 07-016, 07-028

<400> 65
Gly Ser Ser Phe Thr Gly His Asn 
1               5               

<210> 66
<211> 8
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (IMGT) of the heavy chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028,07-031, 07-041, 10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 66
Ile Asp Pro Phe Tyr Gly Gly Thr 
1               5               

<210> 67
<211> 6
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (IMGT) of the heavy chain variable domain
      of antibodies 07-031, 10-001, 10-002, 10-003

<400> 67
Val Ser Gly Met Ile Tyr 
1               5       

<210> 68
<211> 6
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (IMGT) of the heavy chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 68
Val Ser Gly Met Phe Tyr 
1               5       

<210> 69
<211> 6
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (IMGT) of the heavy chain variable domain
      of antibody 07-006

<400> 69
Val Ser Gly Met Tyr Tyr 
1               5       

<210> 70
<211> 6
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (IMGT) of the heavy chain variable domain
      of antibody 07-015, 07-016, 07-028

<400> 70
Val Ser Gly Met Leu Tyr 
1               5       

<210> 71
<211> 11
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR1 (IMGT) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-028, 07-031, 10-001, 10-002, 10-003

<400> 71
Arg Ser Leu Val His Arg Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 72
<211> 11
<212> PRT
<213> Artificial sequence

<220> 
<223> amino acid sequence CDR1 (IMGT) of the light chain variable domain
      of antibodies 07-041, 10-007, 10-008, 10-009

<400> 72
Gln Asn Leu Val His Arg Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 73
<211> 3
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (IMGT) of the light chain variable domain
      of antibodies 07-006, 07-015, 07-016, 07-031, 10-001, 10-002, 10-003

<400> 73
Lys Val Ser 
1               

<210> 74
<211> 3
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (IMGT) of the light chain variable domain
      of antibodies 07-028, 07-041, 10-007, 10-008, 10-009

<400> 74
Lys Val Asn  
1               

<210> 75
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR3 (IMGT) of the light chain variable domain
      of antibodies  07-006, 07-015, 07-016, 07-31, 07-041,
      10-001, 10-002, 10-003, 10-007, 10-008, 10-009

<400> 75
Gly Gln Ser Thr His Val Pro Pro Leu Thr 
1               5                   10  

<210> 76
<211> 10
<212> PRT
<213> Artificial sequence


<220> 
<223> amino acid sequence CDR2 (IMGT) of the light chain variable domain
      of antibody 07-028

<400> 76
Ser Gln Ser Thr His Val Pro Pro Leu Ser 
1               5                   10  

<210> 77
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 07-006


<400> 77
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

tactactggg gtcagggcac tctggtgaca gtgtcgagt                            339


<210> 78
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 07-006

<400> 78
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaa                            339


<210> 79
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 07-015

<400> 79
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggcacaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ctgtactggg gtcagggcac tctggtgaca gtgtcgagt                            339


<210> 80
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 07-015

<400> 80
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccacaa ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaa                            339


<210> 81
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 07-016

<400> 81
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggcacaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ctgtactggg gtcagggcac tctggtgaca gtgtcgagt                            339


<210> 82
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 07-016

<400> 82
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaa                            339


<210> 83
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 07-028

<400> 83
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggcacaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ctgtactggg gtcagggcac tctggtgaca gtgtcgagt                            339


<210> 84
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 07-028

<400> 84
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtaaa caatagattc     180

tccggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgct ctcaaagtac acacgttcca     300

cccctatctt ttggacaagg gaccaagtta gaactgaaa                            339


<210> 85
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 07-031

<400> 85
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

atctactggg gtcagggcac tctggtgaca gtgtcgagt                            339


<210> 86
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 07-031

<400> 86
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccacaa ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaa                            339


<210> 87
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 07-041

<400> 87
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ttctactggg gtcagggcac tctggtgaca gtgtcgagt                            339


<210> 88
<211> 339
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 07-041

<400> 88
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaca gaacctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtaaa caatagattc     180

tccggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaa                            339


<210> 89
<211> 1329
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 10-001

<400> 89
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

atctactggg gtcagggcac tctggtgaca gtgtcgagtg ctagcaccaa gggcccatcg     360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     720

ccaaaaccca aggacaccct ctacatcacc cgggagcctg aggtcacatg cgtggtggtg     780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1020

gaaccacagg tgtacaccct gcccccatcc cgggacgagc tgaccaagaa ccaggtcagc    1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1200

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc    1320

ccgggtaaa                                                            1329


<210> 90
<211> 660
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 10-001

<400> 90
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccacaa ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaac gtacggtggc tgcaccatct     360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     660


<210> 91
<211> 1329
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 10-002

<400> 91
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

atctactggg gtcagggcac tctggtgaca gtgtcgagtg ctagcaccaa gggcccatcg     360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     720

ccaaaaccca aggacaccct ctacatcacc cgggagcctg aggtcacatg cgtggtggtg     780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg cgcggtctcc     960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1020

gaaccacagg tgtacaccct gcccccatcc cgggacgagc tgaccaagaa ccaggtcagc    1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1200

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc    1320

ccgggtaaa                                                            1329


<210> 92
<211> 660
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 10-002

<400> 92
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccacaa ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaac gtacggtggc tgcaccatct     360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     660


<210> 93
<211> 1329
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 10-003

<400> 93
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

atctactggg gtcagggcac tctggtgaca gtgtcgagtg ctagcaccaa gggcccatcg     360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg cgcggtctcc     960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1020

gaaccacagg tgtacaccct gcccccatcc cgggacgagc tgaccaagaa ccaggtcagc    1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1200

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc    1320

ccgggtaaa                                                            1329


<210> 94
<211> 660
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 10-003

<400> 94
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaag gtccctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccacaa ctcctcatcc acaaagtatc caatagattc     180

ggcggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaac gtacggtggc tgcaccatct     360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     660


<210> 95
<211> 1329
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 10-007

<400> 95
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ttctactggg gtcagggcac tctggtgaca gtgtcgagtg ctagcaccaa gggcccatcg     360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     720

ccaaaaccca aggacaccct ctacatcacc cgggagcctg aggtcacatg cgtggtggtg     780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1020

gaaccacagg tgtacaccct gcccccatcc cgggacgagc tgaccaagaa ccaggtcagc    1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1200

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc    1320

ccgggtaaa                                                            1329


<210> 96
<211> 660
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 10-007

<400> 96
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaca gaacctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtaaa caatagattc     180

tccggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaac gtacggtggc tgcaccatct     360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     660


<210> 97
<211> 1329
<212> DNA
<213> Artificial sequence

<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 10-008

<400> 97
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ttctactggg gtcagggcac tctggtgaca gtgtcgagtg ctagcaccaa gggcccatcg     360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     600

aagcccagca acaccaaagt ggacaagaga gttgagccca aatcttgtga caaaactcac     660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     720

ccaaaaccca aggacaccct ctacatcacc cgggagcctg aggtcacatg cgtggtggtg     780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg cgcggtctcc     960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1020

gaaccacagg tgtacaccct gcccccatcc cgggacgagc tgaccaagaa ccaggtcagc    1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1200

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc    1320

ccgggtaaa                                                            1329


<210> 98
<211> 660
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 10-008

<400> 98
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaca gaacctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtaaa caatagattc     180

tccggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaac gtacggtggc tgcaccatct     360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     660


<210> 99
<211> 1329
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      heavy chain variable domain of the antibody 10-009

<400> 99
caggtacaac tcgtacaatc tggggccgaa gtgaagaaac caggcgcttc cgttaaggtg      60

tcctgcaaag ccagcgggag ctcgttcaca gggaagaaca tgaattgggt ccgacagaac     120

attggacagg gattagaatg gatgggcgct atagatccct tctatggagg cacatcctac     180

aaccagaaat tcaagggccg cgttaccctc acagtcgata agtctatctc taccgcatac     240

atggaactgt cccgcttacg gtcggatgat acagcagtgt actattgtgt tagtgggatg     300

ttctactggg gtcagggcac tctggtgaca gtgtcgagtg ctagcaccaa gggcccatcg     360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc     420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc     480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc     540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac     600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac     660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg cgcggtctcc     960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    1020

gaaccacagg tgtacaccct gcccccatcc cgggacgagc tgaccaagaa ccaggtcagc    1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc    1200

ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca    1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaaaagcct ctccctgtcc    1320

ccgggtaaa                                                            1329


<210> 100
<211> 660
<212> DNA
<213> Artificial sequence


<220> 
<223> Nucleic acid that encodes the amino acid sequence of the 
      light chain variable domain of the antibody 10-009

<400> 100
gatatcgtga tgacacaaac cccattgagc ctgtccgtga cgccaggaga gcgcgctagt      60

ttaagttgtc ggagttcaca gaacctggtt caccggaatg gcaataccta cttgcactgg     120

tacttgcaga aacctgggca gtcgccaaag ctcctcatcc acaaagtaaa caatagattc     180

tccggcgtgc cagatagatt ctctggctct ggttctggta cagattttac tctgaagatt     240

tctcgggtgg aggccgagga cgtaggggtg tacttctgcg gccaaagtac acacgttcca     300

cccctaacct ttggacaagg gaccaagtta gaactgaaac gtacggtggc tgcaccatct     360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     660


