                         SEQUENCE LISTING

<110>  Stichting VU
 
<120>  Inhibitors of the Wnt signaling pathway and uses thereof

<130>  P129812PC00

<140>  PCT/NL2022/050162
<141>  2022-03-24

<150>  EP 21164713.6
<151>  2021-03-24

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a positively charged or polar aa, or forms bridge with X at 
       position 9

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any aa, or forms bridge with X at position 8

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a negatively charged aa or an amide, or forms bridge with X 
       at position 7

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a hydrophobic aa, or forms bridge with X at position 6

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a negatively charged aa, or an amide, or forms bridge with X
       at position 4

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can be any aa, or forms bridge with X at position 3

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a hydrophobic aa, or forms bridge with X at position 2

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a hydrophobic aa, or forms bridge with X at position 1

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  2
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCF-4 tracer peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Linked to Fluorescein-PEG2

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  bAla

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  bAla

<400>  2

Asp Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Xaa Xaa Glu 
1               5                   10                  15      


Arg Asp Leu Ala Asp Val Lys Ser Ser Leu Val Asn 
            20                  25              


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 12


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  3

Xaa Val Thr Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Val Phe Xaa 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 12K631-Fl


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  K linked to Fluorescein

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  4

Xaa Val Thr Arg Lys Asp Val Xaa Pro Asp Ser Leu Leu Val Phe Xaa 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide A-o


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  5

Xaa Val Cys Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Cys Phe Xaa 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide B-o


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  6

Xaa Val Thr Arg Cys Asp Val Xaa Pro Asp Ser Cys Leu Val Phe Xaa 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide C-o


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  7

Xaa Val Thr Arg Asn Cys Val Xaa Pro Asp Cys Leu Leu Val Phe Xaa 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide A-ox


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  8

Xaa Val Cys Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Cys Phe Xaa 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide A-b1


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  9

Xaa Val Cys Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Cys Phe Xaa 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide A-b6K631-F1


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  K is linked to fluorescein

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  10

Xaa Val Cys Arg Lys Asp Val Xaa Pro Asp Ser Leu Leu Cys Phe Xaa 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide B-ox


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  forms a bridge with position 12

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  forms a bridge with position 5

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  11

Xaa Val Thr Arg Cys Asp Val Xaa Pro Asp Ser Cys Leu Val Phe Xaa 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide C-ox


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  forms a bridge with position 11

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  forms a bridge with position 6

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  12

Xaa Val Thr Arg Asn Cys Val Xaa Pro Asp Cys Leu Leu Val Phe Xaa 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide St-1


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is (S)-2-(4'-pentenyl)glycine,forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  13

Xaa Val Xaa Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Xaa Phe Xaa 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide St-2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is (S)-2-(5'-hexenyl)glycine, forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  14

Xaa Val Xaa Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Xaa Phe Xaa 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide St-3


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is (S)-2-(5'-hexenyl)glycine), forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  15

Xaa Val Xaa Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Xaa Phe Xaa 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide St-4


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is (S)-2-(5'-hexenyl)glycine, forms a bridge with position 14

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is (S)-2-(5'-hexenyl)glycine, forms a bridge with position 3

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  16

Xaa Val Xaa Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Xaa Phe Xaa 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide St-5


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 12

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 5

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  17

Xaa Val Thr Arg Xaa Asp Val Xaa Pro Asp Ser Xaa Leu Val Phe Xaa 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide St-6


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  bAla, linked to position 16

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 11

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D-amino acid Pro

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is (S)-2-(4'-pentenyl)glycine, forms a bridge with position 6

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  bAla, linked to position 1

<400>  18

Xaa Val Thr Arg Asn Xaa Val Xaa Pro Asp Xaa Leu Leu Val Phe Xaa 
1               5                   10                  15      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any aa, or forms bridge with position 11

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is a positively charged or polar amino aa, or forms bridge with
       position 10

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can be any aa, or forms bridge with position 9

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a negatively charged aa or an amide, or forms bridge with 
       position 8

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a is a hydrophobic aa, or forms bridge with position 7

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a negatively charged aa, or an amide,  or forms bridge with 
       position 5

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can be any aa, or forms bridge with position 4

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is a hydrophobic aa, or forms bridge with position 3

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a hydrophobic aa, or forms bridge with position 2

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a hydrophobic aa, or forms bridge with position 1

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any aa, or forms a bridge with position 13

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can be any aa, or forms a bridge with position 12

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a positively charged or polar aa, or forms a bridge with 
       position 11

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be any aa, or forms a bridge with position 10

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a negatively charged aa or an amide, or forms a bridge with 
       position 9

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a hydrophobic aa, or forms a bridge with position 8

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is a negatively charged aa, or an amide, or forms a bridge with
       position 6

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X can be any aa, or forms a bridge with position 5

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is a hydrophobic aa, or forms a bridge with position 4

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is a hydrophobic aa, or forms a bridge with position 3

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is a hydrophobic aa, or forms a bridge with position 2

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is an aromatic aa, or forms a bridge with position 1

<400>  20

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X forms a bridge with position 9 or is Arg, or a corresponding 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X forms a bridge with position 8 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X forms a bridge with position 7 or is selected from Asp, Glu, 
       Asn, and Gln, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X forms a bridge with position 6 or is selected from Val, Leu and
       Ile, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X forms a bridge with position 4 or is selected from Asp, Glu, 
       Asn, and Gln, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X forms a bridge with position 3 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X forms a bridge with position 2 or is selected from Val, Leu, 
       Ile and Cys, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X forms a bridge with position 1 or is selected from Val, Leu, 
       Ile and Cys, or corresponding non-natural amino acids

<400>  21

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X forms bridge with position 11 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X forms bridge with position 10 or is Arg, or a corresponding 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X forms bridge with position 9, or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X forms bridge with position 8 or is selected from Asp, Glu, Asn,
       and Gln, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X forms bridge with position 7 or is selected from Val, Leu and 
       Ile, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is linker

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X forms bridge with position 5 or is selected from Asp, Glu, Asn,
       and Gln

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X forms bridge with position 4 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X forms bridge with position 3 or is selected from Val, Leu, Ile 
       and Cys, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X forms bridge with position 2 or is selected from Val, Leu, Ile 
       and Cys, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X forms bridge with position 1 or is selected from Val, Leu, Ile 
       and Cys, or corresponding non-natural amino acids

<400>  22

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X forms bridge with position 13 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X forms bridge with position 12 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X forms bridge with position 11 or is Arg, or a corresponding 
       non-natural amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X forms bridge with position 10, or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X forms bridge with position 9, or is selected from Asp, Glu, 
       Asn, and Gln, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X forms bridge with position 8, or is selected from Val, Leu and 
       Ile, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X forms a bridge with position 6 or is selected from Asp, Glu, 
       Asn, and Gln, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X forms a bridge with position 5 or can be any aa

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X forms a bridge with position 4 or is selected from Val, Leu, 
       Ile and Cys, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X forms a bridge with position 3 or is selected from Val, Leu, 
       Ile and Cys, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X forms a bridge with position 2 or is selected from Val, Leu, 
       Ile and Cys, or corresponding non-natural amino acids

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X forms a bridge with position 1 or is selected from Phe, Tyr, 
       His and Trp, or corresponding non-natural amino acids

<400>  23

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X forms a bridge with position 9 or is Arg

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X forms a bridge with position 8 or is Asn

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X forms a bridge with position 7 or is Asp

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X forms a bridge with position 6 or is Val

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X forms a bridge with position 4 or is Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X forms a bridge with position 3 or is Ser

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X forms a bridge with position 2 or is Leu

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X forms a bridge with position 1 or is Leu

<400>  24

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X forms a bridge with position 11 or is Thr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X forms a bridge with position 10 or is Arg

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X forms a bridge with position 9 or is Asn

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X forms a bridge with position 8 or is Asp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X forms a bridge with position 7 or is Val

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X forms a bridge with position 5 or is Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X forms a bridge with position 4 or is Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X forms a bridge with position 3 or is Leu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X forms a bridge with position 2 or is Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X forms a bridge with position 1 or is Val

<400>  25

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cyclic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X forms a bridge with position 13 or is Val

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X forms a bridge with position 12 or is Thr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X forms a bridge with position 11 or is Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X forms a bridge with position 10 or is Asn

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X forms a bridge with position 9 or is Asp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X forms a bridge with position 8 or is Val

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is a linker

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X forms a bridge with position 6 or is Asp

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X forms a bridge with position 5 or is Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X forms a bridge with position 4 or is Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X forms a bridge with position 3 or is Leu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X forms a bridge with position 2 or is Val

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X forms a bridge with position 1 or is Phe

<400>  26

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  27
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-CBD peptide

<400>  27

Val Thr Arg Asn Asp Val Ala Pro Thr Leu Asx Ser Val Pro Gln Tyr 
1               5                   10                  15      


Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu 
            20                  25                  30          


Asn Leu Lys Ala Ala Asp Ser Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
        35                  40                  45              


Leu Leu Val Phe 
    50          


<210>  28
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 1

<400>  28

Pro Thr Leu Asx Ser Val Pro Gln Tyr Arg Pro Arg Pro Ala Asn Pro 
1               5                   10                  15      


Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala Asp Ser 
            20                  25                  30          


Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe 
        35                  40                  45  


<210>  29
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 2

<400>  29

Pro Gln Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe 
1               5                   10                  15      


Ile Asp Glu Asn Leu Lys Ala Ala Asp Ser Asp Pro Thr Ala Pro Pro 
            20                  25                  30          


Tyr Asp Ser Leu Leu Val Phe 
        35                  


<210>  30
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 3

<400>  30

Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala Asp Ser Asp 
1               5                   10                  15      


Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe 
            20                  25              


<210>  31
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 4


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is D-amino acid Pro

<400>  31

Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp 
1               5                   10                  15      


Glu Asn Leu Lys Ala Ala Asp Ser Asn Pro Thr Ala Pro Pro Tyr Asp 
            20                  25                  30          


Ser Leu Leu Val Phe Xaa Pro Gly Val Thr Arg Asn Asp Val Ala Pro 
        35                  40                  45              


Thr Leu Asx Ser Val Pro Gln 
    50                  55  


<210>  32
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 5


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is D-amino acid Pro

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  bAla

<400>  32

Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp 
1               5                   10                  15      


Glu Asn Leu Lys Ala Ala Asp Ser Asn Pro Thr Ala Pro Pro Tyr Asp 
            20                  25                  30          


Ser Leu Leu Val Phe Xaa Pro Xaa Val Thr Arg Asn Asp Val Ala Pro 
        35                  40                  45              


Thr Leu Asx Ser Val Pro Gln 
    50                  55  


<210>  33
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 6


<220>
<221>  MOD_RES
<222>  (38)..(39)
<223>  bAla

<400>  33

Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp 
1               5                   10                  15      


Glu Asn Leu Lys Ala Ala Asp Ser Asn Pro Thr Ala Pro Pro Tyr Asp 
            20                  25                  30          


Ser Leu Leu Val Phe Xaa Xaa Val Thr Arg Asn Asp Val Ala Pro Thr 
        35                  40                  45              


Leu Asx Ser Val Pro Gln 
    50                  


<210>  34
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 7


<220>
<221>  MOD_RES
<222>  (38)..(40)
<223>  bAla

<400>  34

Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp 
1               5                   10                  15      


Glu Asn Leu Lys Ala Ala Asp Ser Asn Pro Thr Ala Pro Pro Tyr Asp 
            20                  25                  30          


Ser Leu Leu Val Phe Xaa Xaa Xaa Val Thr Arg Asn Asp Val Ala Pro 
        35                  40                  45              


Thr Leu Asx Ser Val Pro Gln 
    50                  55  


<210>  35
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 8


<220>
<221>  MOD_RES
<222>  (32)..(33)
<223>  bAla

<400>  35

Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala 
1               5                   10                  15      


Asp Ser Asn Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Xaa 
            20                  25                  30          


Xaa Val Thr Arg Asn Asp Val Ala Pro Thr Leu Asx Ser Val Pro Gln 
        35                  40                  45              


<210>  36
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 9


<220>
<221>  MOD_RES
<222>  (7)..(8)
<223>  bAla

<400>  36

Asp Ser Leu Leu Val Phe Xaa Xaa Val Thr Arg Asn Asp Val Ala Pro 
1               5                   10                  15      


Thr Leu Asx Ser Val Pro Gln 
            20              


<210>  37
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 10


<220>
<221>  MOD_RES
<222>  (38)..(39)
<223>  bAla

<400>  37

Tyr Arg Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp 
1               5                   10                  15      


Glu Asn Leu Lys Ala Ala Asp Ser Asn Pro Thr Ala Pro Pro Tyr Asp 
            20                  25                  30          


Ser Leu Leu Val Phe Xaa Xaa Val Thr Arg Asn Asp Val 
        35                  40                  45  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 11


<220>
<221>  MOD_RES
<222>  (7)..(8)
<223>  bAla

<400>  38

Asp Ser Leu Leu Val Phe Xaa Xaa Val Thr Arg Asn Asp Val 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 12-l


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is D-amino acid Pro

<400>  39

Val Thr Arg Asn Asp Val Xaa Pro Asp Ser Leu Leu Val Phe 
1               5                   10                  


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tat

<400>  40

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


