                               SEQUENCE LISTING

<110> MINA THERAPEUTICS LIMITED
                   
<120> TMEM173 SARNA COMPOSITIONS AND METHODS OF USE

<130> 2058.1034PCT

<140>
<141> 

<150>  US63/166,390
<151>  2021-03-26

<150>  US63/318,927
<151>  2022-03-11

<160> 85    

<170> PatentIn version 3.5

<210> 1
<211> 4001
<212> DNA
<213> Homo sapiens

<400> 1
gtcacagagg ccttcagaat gaagacccaa agacagaggg caaattgtct atttttacgt       60

ttaggttcat taaagtatgg acacccttgt tgaaatataa ttggacagaa agggtatgct      120

ctaatgctaa tagaatgagt ggggaaaccc agcctcgccc gtctgtctag attcttcttg      180

gcctctctga gcgtgtgttc cttctttctg agtgtggggc agggccctct ctggaagggg      240

gattttataa tctacactca aacaatgtag gtcagacctt cccttccctt cccttccctt      300

cccttccttc ctttctctct ctctcttttt ctttctttct tctctttttt ttttttttga      360

gacggagttt tgctcttgtc gcccaggctg gagtgcaatg gcacgatctc ggctcagtgc      420

aacctccgcc tcccaggttc aagcagttct cctgcctcag cctcccaaga agctgggatt      480

acaggcatgc gccatcacgc ccagctaatt ttttgtattt ttagtagaga tggggtttct      540

ccatgttggt caggatggtc ttgaactcct gacctcaggt gatctgcctg ccttggcctc      600

ccaaattgct gggattatag gagtgagcca ctgcacccgg cctttttttt tttttttttt      660

gagatggagt ttgactcttg ttgccgaggc tggagtgcag tggcatgatc tcggctcacc      720

gcaagctccg cctcctgggt tcaagcgatt ctcctgcctc agcctcctga gtagctggga      780

ttataggcac ccgccaccac gcccagcgaa ttttttgtac ttttagtaga gatggggttt      840

cactatgttg gccaggctgg tctcgaactc ctgacctcaa gtgatccatt tgccttggcc      900

tcccaaagtg cgaggattac aaggatgagc cattgcgcct ggcctatttt tttttttttt      960

tttttgagat agggtatcac tctgtcactt aggctggagt gcagtggtgc catcacaact     1020

cactgcaacc tctacctcca ggggtcaagt gatgctccca cctcagcctc ccaagtagct     1080

gggactatag gcgtgttccg tcatgcttgg ctaatttttt tttttttttt ttgtagagat     1140

gggatctccc tgtgttgctt aggctggtct caaacttctg ggctcaagtg atcctcctgc     1200

cttggcctcc caaagtgctg ggattactgg aatgaaatca aggcacagag caagctgggc     1260

tttggagcaa cccaccaggc ttcaagtccc cactctcaat tacttaaacc agttatttca     1320

cctccctgag cctcggatta tccatctata aaatggggct agaattatac ctacctgaca     1380

gggtggctgg tgaaatgata tacaagtgaa gtgatatatg caacacttgg cataatgtct     1440

ggaacaaggt aaacacttta ttattattat tattattata atttaggttg atgcatgggg     1500

attttataac ctacactcaa acaatgtagg tcagatcatt tttcttttct tttcttttct     1560

tttcttttga gacagtctcg ctcttgttgc ccaggctgga gtgcagtggc ctaatctctg     1620

ctcactgcaa cttccacctc tcaggttcca gcgattctcc tgcctcagcc tcccaagtag     1680

ctaagattac aagcgcccac caccacgcct ggctaatttt tgtttttagt agagatgggg     1740

tttcaccatg ttgctcaggc tggtcttgaa ctcctgacct caagtgatcc acccatctcg     1800

gcctcccaaa gcgctgggat tacaggcatg agccactgtg ccaggcctgc aattactttt     1860

gctcctacct aatatcatcc ccacaaccgc cttctgggca gaaaccggca ggctctcttg     1920

gagaagtcac aggcgtggcc atttcctgca aagagccaaa cccccattcc tctgtgcccc     1980

tcctctccca ccaagtgctt tataaaaata gctcttgtta ccggaaataa ctgttcattt     2040

ttcactcctc cctcctaggt cacacttttc agaaaaagaa tctgcatcct ggaaaccaga     2100

agaaaaatat gagacgggga atcatcgtgt gatgtgtgtg ctgcctttgg ctgagtgtgt     2160

ggagtcctgc tcaggtgtta ggtacagtgt gtttgatcgt ggtggcttga ggggaacccg     2220

ctgttcagag ctgtgactgc ggtgagtgtt tctaaacacc cttggtttgg gggtagcaaa     2280

gggcaatgga atggaggctt tctcaaacct cacccctgac cccaggactc aggcccagct     2340

catcagggct ttgagggaag gttcctacct cccttcctga ggaacaggaa ataccctcct     2400

tcccagcacc agtaaagctg cggtttggag aaacgccagg gctagagtgt tgtggagaaa     2460

ccaatcgttg ttaacatctc attttcaggc tgcactcaga gaagctgccc ttggctgctc     2520

gtagcgccgg gccttctctc ctcgtcatca tccagagcag ccagtgtccg ggaggcagaa     2580

ggtaggctca agatcagcct ggcagaacgc caaacctagg gcccctggca cccagaggcg     2640

agggggtgcc tgctggctgc cctgtcccca ctccctgagc tctgttttcc actttgttga     2700

ctaaggtcct ccctggggtg ggttccgggg acaggggaac ccaggtcccc aagggttctt     2760

ggttgggtac ggctgcacag gacagcttca agtctgggtc tgggatagtt gctgccttct     2820

ttcttcacca cacctgtggt ctccctgggt cttggtgggg cgtgtatgtg caggccctgc     2880

tctgttttca gcaaacctcg ctgagacagg agctttgggg tgacttattc ccagcctgcc     2940

tcctagaggt gtctctaaga gcagcctctg ggagtggctg ggcaccaggg aaaggggaac     3000

tgggaggaag tgcccagcca gagcctcagt cccagaaggg caggagggca aggggagaat     3060

ggtcatggat ttcttggtgc ccacagatgc cccactccag cctgcatcca tccatcccgt     3120

gtcccagggg tcacggggcc cagaaggcag ccttggttct gctgagtgcc tgcctggtga     3180

ccctttgggg gctaggagag ccaccagagc acactctccg gtacctggtg ctccacctag     3240

cctccctgca gctgggactg ctgttaaacg gggtctgcag cctggctgag gagctgcgcc     3300

acatccactc caggtgactc actgcagtac ccagggacgg ggtatccaac gtgtgtcact     3360

cccttgatgc ctagccctgc ccctccttga acctctctgg ctgagctggg ctgggggctg     3420

gggtctgggg tctggctgtc actcacaggt accggggcag ctactggagg actgtgcggg     3480

cctgcctggg ctgccccctc cgccgtgggg ccctgttgct gctgtccatc tatttctact     3540

actccctccc aaatgcggtc ggcccgccct tcacttggat gcttgccctc ctgggcctct     3600

cgcaggcact gaacatcctc ctgggcctca aggtatgaca cagggggagg tagaagctct     3660

ggccaagtgg tggctgtggc tggtgtgacc tgccctgagc tgagtactgg gagtgggact     3720

ggtttaaagg ctggagtcca tggagtagaa cctataatgt cctggaacag tgggtttggc     3780

aatggcaaaa gagggatcaa gtcaggagca ggttgggaag ccttggagga ggaggaggag     3840

ttctctgggt gtccttgatg gaggcccccc agccacatcc tgctgtccac agggcctggc     3900

cccagctgag atctctgcag tgtgtgaaaa agggaatttc aacgtggccc atgggctggc     3960

atggtcatat tacatcggat atctgcggct gatcctgcca g                         4001


<210> 2
<211> 19
<212> DNA
<213> Homo sapiens

<400> 2
gcagatatcc gatgtaata                                                    19


<210> 3
<211> 19
<212> DNA
<213> Homo sapiens

<400> 3
ccaagtgttg catatatca                                                    19


<210> 4
<211> 19
<212> DNA
<213> Homo sapiens

<400> 4
gtgtttacct tgttccaga                                                    19


<210> 5
<211> 19
<212> DNA
<213> Homo sapiens

<400> 5
atgagatgtt aacaacgat                                                    19


<210> 6
<211> 19
<212> DNA
<213> Homo sapiens

<400> 6
acgattggtt tctccacaa                                                    19


<210> 7
<211> 19
<212> DNA
<213> Homo sapiens

<400> 7
aaccaagggt gtttagaaa                                                    19


<210> 8
<211> 19
<212> DNA
<213> Homo sapiens

<400> 8
gtaggaacct tccctcaaa                                                    19


<210> 9
<211> 19
<212> DNA
<213> Homo sapiens

<400> 9
caggatcagc cgcagatat                                                    19


<210> 10
<211> 19
<212> DNA
<213> Homo sapiens

<400> 10
gggagggagt agtagaaat                                                    19


<210> 11
<211> 19
<212> DNA
<213> Homo sapiens

<400> 11
tcctgtctca gcgaggttt                                                    19


<210> 12
<211> 19
<212> DNA
<213> Homo sapiens

<400> 12
aacgattggt ttctccaca                                                    19


<210> 13
<211> 19
<212> DNA
<213> Homo sapiens

<400> 13
caacgattgg tttctccac                                                    19


<210> 14
<211> 19
<212> DNA
<213> Homo sapiens

<400> 14
cgattggttt ctccacaac                                                    19


<210> 15
<211> 19
<212> DNA
<213> Homo sapiens

<400> 15
gattggtttc tccacaaca                                                    19


<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
gcagauaucc gauguaaua                                                    19


<210> 17
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ccaaguguug cauauauca                                                    19


<210> 18
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
guguuuaccu uguuccaga                                                    19


<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
augagauguu aacaacgau                                                    19


<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
acgauugguu ucuccacaa                                                    19


<210> 21
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
aaccaagggu guuuagaaa                                                    19


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
guaggaaccu ucccucaaa                                                    19


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
caggaucagc cgcagauau                                                    19


<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gggagggagu aguagaaau                                                    19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
uccugucuca gcgagguuu                                                    19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
aacgauuggu uucuccaca                                                    19


<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
caacgauugg uuucuccac                                                    19


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
cgauugguuu cuccacaac                                                    19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gauugguuuc uccacaaca                                                    19


<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
uauuacaucg gauaucugc                                                    19


<210> 31
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ugauauaugc aacacuugg                                                    19


<210> 32
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ucuggaacaa gguaaacac                                                    19


<210> 33
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
aucguuguua acaucucau                                                    19


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
uuguggagaa accaaucgu                                                    19


<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
uuucuaaaca cccuugguu                                                    19


<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
uuugagggaa gguuccuac                                                    19


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
auaucugcgg cugauccug                                                    19


<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
auuucuacua cucccuccc                                                    19


<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
aaaccucgcu gagacagga                                                    19


<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
uguggagaaa ccaaucguu                                                    19


<210> 41
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
guggagaaac caaucguug                                                    19


<210> 42
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
guuguggaga aaccaaucg                                                    19


<210> 43
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
uguuguggag aaaccaauc                                                    19


<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 44
gcagauaucc gauguaauau u                                                 21


<210> 45
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 45
ccaaguguug cauauaucau u                                                 21


<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 46
guguuuaccu uguuccagau u                                                 21


<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 47
augagauguu aacaacgauu u                                                 21


<210> 48
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 48
acgauugguu ucuccacaau u                                                 21


<210> 49
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 49
aaccaagggu guuuagaaau u                                                 21


<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 50
guaggaaccu ucccucaaau u                                                 21


<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 51
caggaucagc cgcagauauu u                                                 21


<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 52
gggagggagu aguagaaauu u                                                 21


<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 53
uccugucuca gcgagguuuu u                                                 21


<210> 54
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 54
aacgauuggu uucuccacau u                                                 21


<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 55
caacgauugg uuucuccacu u                                                 21


<210> 56
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 56
cgauugguuu cuccacaacu u                                                 21


<210> 57
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 57
gauugguuuc uccacaacau u                                                 21


<210> 58
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 58
nacgauuggu uucuccacaa uu                                                22


<210> 59
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 59
naacgauugg uuucuccaca uu                                                22


<210> 60
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 60
ncaacgauug guuucuccac uu                                                22


<210> 61
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 61
ncgauugguu ucuccacaac uu                                                22


<210> 62
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 62
ngauugguuu cuccacaaca uu                                                22


<210> 63
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inv ddT

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 63
tacgauuggu uucuccacaa uu                                                22


<210> 64
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inv ddT

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 64
taacgauugg uuucuccaca uu                                                22


<210> 65
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inv ddT

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 65
tcaacgauug guuucuccac uu                                                22


<210> 66
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inv ddT

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 66
tcgauugguu ucuccacaac uu                                                22


<210> 67
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inv ddT

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 67
tgauugguuu cuccacaaca uu                                                22


<210> 68
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(1)
<223> Inv ddT

<220>
<221> modified_base
<222> (2)..(3)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-OMe modified nucleotide

<220>
<221> modified_base
<222> (21)..(22)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 68
tcgauugguu ucuccacaac uu                                                22


<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 69
uauuacaucg gauaucugcu u                                                 21


<210> 70
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 70
ugauauaugc aacacuuggu u                                                 21


<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 71
ucuggaacaa gguaaacacu u                                                 21


<210> 72
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 72
aucguuguua acaucucauu u                                                 21


<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 73
uuguggagaa accaaucguu u                                                 21


<210> 74
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 74
uuucuaaaca cccuugguuu u                                                 21


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 75
uuugagggaa gguuccuacu u                                                 21


<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 76
auaucugcgg cugauccugu u                                                 21


<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 77
auuucuacua cucccucccu u                                                 21


<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 78
aaaccucgcu gagacaggau u                                                 21


<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 79
uguggagaaa ccaaucguuu u                                                 21


<210> 80
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 80
guggagaaac caaucguugu u                                                 21


<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 81
guuguggaga aaccaaucgu u                                                 21


<210> 82
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 82
uguuguggag aaaccaaucu u                                                 21


<210> 83
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 83
guuguggaga aaccaaucgu u                                                 21


<210> 84
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> Inverted abasic nucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 84
cgauugguuu cacgagaucu u                                                 21


<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (20)..(21)
<223> 2'-OMe modified nucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 85
gaucucguga aaccaaucgu u                                                 21



