                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals S.A.
 
<120>  IMMUNOGENIC COMPOSITIONS

<130>  VB66985WO02

<150>  US 63/166539
<151>  2021-03-26

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  198
<212>  PRT
<213>  Influenza A virus

<400>  1

Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
1               5                   10                  15      


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
            20                  25                  30          


Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln Arg 
        35                  40                  45              


Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly 
    50                  55                  60                  


Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu 
65                  70                  75                  80  


Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile 
                85                  90                  95      


Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val Leu Leu Leu Asn 
        115                 120                 125             


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    130                 135                 140                 


Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
145                 150                 155                 160 


Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser Val 
                165                 170                 175     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu 
            180                 185                 190         


Asn Arg Glu Lys Ile Asp 
        195             


<210>  2
<211>  198
<212>  PRT
<213>  Influenza A virus

<400>  2

Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
1               5                   10                  15      


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
            20                  25                  30          


Gly Ser Gly Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile 
        35                  40                  45              


Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly 
    50                  55                  60                  


Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu 
65                  70                  75                  80  


Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile 
                85                  90                  95      


Asp Lys Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly Ser 
            100                 105                 110         


Gly Gly Ser Gly Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Leu Asn 
        115                 120                 125             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    130                 135                 140                 


Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
145                 150                 155                 160 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                165                 170                 175     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            180                 185                 190         


Asn Arg Glu Lys Ile Asp 
        195             


<210>  3
<211>  212
<212>  PRT
<213>  Influenza A virus

<400>  3

Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Phe Pro Gly Cys Gly 
        35                  40                  45              


Val Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
    50                  55                  60                  


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
65                  70                  75                  80  


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
                85                  90                  95      


Ile Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln 
            100                 105                 110         


Ile Asn Gly Met Val Asn Arg Val Ile Glu Leu Met Glu Gln Gly Gly 
        115                 120                 125             


Pro Asp Cys Tyr Leu Ala Glu Leu Leu Val Ala Leu Leu Asn Gln His 
    130                 135                 140                 


Val Ile Asp Leu Thr Asp Ser Glu Met Arg Lys Leu Phe Glu Arg Thr 
145                 150                 155                 160 


Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe 
                165                 170                 175     


Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn 
            180                 185                 190         


Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg 
        195                 200                 205             


Phe Gln Ile Lys 
    210         


<210>  4
<211>  204
<212>  PRT
<213>  Influenza A virus

<400>  4

Leu Asp Lys Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Leu Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Phe Pro Gly Cys Gly Val Leu Met Leu Ala Thr Gly Met Arg 
        35                  40                  45              


Asn Val Pro Glu Leu Ile Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala 
    50                  55                  60                  


Gly Phe Leu Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
65                  70                  75                  80  


Phe Arg His Gln Asn Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr Lys 
                85                  90                  95      


Ser Thr Gln Ala Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg Val 
            100                 105                 110         


Val Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu Leu 
        115                 120                 125             


Leu Val Ala Met Leu Asn Gln His Val Ile Asp Met Ala Asp Ser Glu 
    130                 135                 140                 


Met Arg Asn Leu Tyr Glu Arg Val Arg Lys Gln Leu Arg Gln Asn Ala 
145                 150                 155                 160 


Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile Tyr His Ala Cys Asp Asp 
                165                 170                 175     


Ser Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Gln Tyr 
            180                 185                 190         


Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn Ile Asn 
        195                 200                 


<210>  5
<211>  163
<212>  PRT
<213>  Helicobacter pylori

<400>  5

Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
1               5                   10                  15      


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
            20                  25                  30          


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
        35                  40                  45              


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
    50                  55                  60                  


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
65                  70                  75                  80  


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
                85                  90                  95      


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
            100                 105                 110         


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
        115                 120                 125             


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
    130                 135                 140                 


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
145                 150                 155                 160 


Arg Lys Ser 
            


<210>  6
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H1ssF_pylori (subgenomic 
       promoter-stabilised HA stem from A/New Caledonia/20/1999 
       (H1N1)-SGG-H. pylori ferritin)

<400>  6

Met Lys Ala Lys Leu Leu Val Leu Leu Cys Thr Phe Thr Ala Thr Tyr 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Gln 
    50                  55                  60                  


Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asn Gly Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Thr Asp Leu Ala Glu Leu Leu Val Leu Leu Leu 
    130                 135                 140                 


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
145                 150                 155                 160 


Glu Lys Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asn Asn Glu Cys Met Glu Ser 
            180                 185                 190         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys 
        195                 200                 205             


Leu Asn Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu 
    210                 215                 220                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
225                 230                 235                 240 


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                245                 250                 255     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            260                 265                 270         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        275                 280                 285             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    290                 295                 300                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
305                 310                 315                 320 


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                325                 330                 335     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            340                 345                 350         


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
        355                 360                 365             


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
    370                 375                 380             


<210>  7
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H1ssF_pylori (subgenomic 
       promoter-stabilised HA stem from A/Michigan/45/2015 (H1N1)-SGG-H.
       pylori ferritin)

<400>  7

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser 
    50                  55                  60                  


Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asp Lys Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Leu 
    130                 135                 140                 


Asn Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr 
145                 150                 155                 160 


Glu Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser 
            180                 185                 190         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys 
        195                 200                 205             


Leu Asn Arg Glu Lys Ile Asp Ser Gly Gly Asp Ile Ile Lys Leu Leu 
    210                 215                 220                 


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
225                 230                 235                 240 


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
                245                 250                 255     


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
            260                 265                 270         


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
        275                 280                 285             


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
    290                 295                 300                 


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
305                 310                 315                 320 


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
                325                 330                 335     


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
            340                 345                 350         


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
        355                 360                 365             


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
    370                 375                 380     


<210>  8
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H3ssF_pylori (signal peptide-stabilised 
       HA stem from A/Finland/486/2004 (H3N2)-SGG-H. pylori ferritin)

<400>  8

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Phe Pro Gly Cys Gly 
    50                  55                  60                  


Val Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
65                  70                  75                  80  


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
                85                  90                  95      


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
            100                 105                 110         


Ile Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln 
        115                 120                 125             


Ile Asn Gly Met Val Asn Arg Val Ile Glu Leu Met Glu Gln Gly Gly 
    130                 135                 140                 


Pro Asp Cys Tyr Leu Ala Glu Leu Leu Val Ala Leu Leu Asn Gln His 
145                 150                 155                 160 


Val Ile Asp Leu Thr Asp Ser Glu Met Arg Lys Leu Phe Glu Arg Thr 
                165                 170                 175     


Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe 
            180                 185                 190         


Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn 
        195                 200                 205             


Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg 
    210                 215                 220                 


Phe Gln Ile Lys Ser Gly Gly Asp Ile Ile Lys Leu Leu Asn Glu Gln 
225                 230                 235                 240 


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
                245                 250                 255     


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
            260                 265                 270         


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
        275                 280                 285             


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
    290                 295                 300                 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
305                 310                 315                 320 


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
                325                 330                 335     


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
            340                 345                 350         


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
        355                 360                 365             


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
    370                 375                 380                 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
385                 390                 


<210>  9
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H10ssF_pylori (signal peptide-stabilised 
       HA stem from A/Jiangxi/IPB13/2013 (H10N8)-SGG-H. pylori ferritin)

<400>  9

Met Tyr Lys Ile Val Val Ile Ile Ala Leu Leu Gly Ala Val Lys Gly 
1               5                   10                  15      


Leu Asp Lys Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr Ile 
            20                  25                  30          


Val Lys Thr Leu Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 
        35                  40                  45              


Leu Val Phe Pro Gly Cys Gly Val Leu Met Leu Ala Thr Gly Met Arg 
    50                  55                  60                  


Asn Val Pro Glu Leu Ile Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala 
65                  70                  75                  80  


Gly Phe Leu Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
                85                  90                  95      


Phe Arg His Gln Asn Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr Lys 
            100                 105                 110         


Ser Thr Gln Ala Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg Val 
        115                 120                 125             


Val Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu Leu 
    130                 135                 140                 


Leu Val Ala Met Leu Asn Gln His Val Ile Asp Met Ala Asp Ser Glu 
145                 150                 155                 160 


Met Arg Asn Leu Tyr Glu Arg Val Arg Lys Gln Leu Arg Gln Asn Ala 
                165                 170                 175     


Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile Tyr His Ala Cys Asp Asp 
            180                 185                 190         


Ser Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Gln Tyr 
        195                 200                 205             


Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn Ile Asn Ser Gly Gly Asp 
    210                 215                 220                 


Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser 
225                 230                 235                 240 


Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp 
                245                 250                 255     


Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His 
            260                 265                 270         


Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln 
        275                 280                 285             


Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln 
    290                 295                 300                 


Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile 
305                 310                 315                 320 


Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe 
                325                 330                 335     


Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu 
            340                 345                 350         


Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His 
        355                 360                 365             


Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg 
    370                 375                 380                 


Lys Ser 
385     


<210>  10
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of stabilised HA stem from A/Anhui/1/2013 
       (H7N9)

<400>  10

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Leu 
            20                  25                  30          


Val Phe Pro Gly Cys Gly Val Leu Lys Leu Ala Thr Gly Met Lys Asn 
        35                  40                  45              


Val Pro Glu Ile Pro Lys Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly 
    50                  55                  60                  


Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe 
65                  70                  75                  80  


Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser 
                85                  90                  95      


Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg Val Ile 
            100                 105                 110         


Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu Leu Leu 
        115                 120                 125             


Val Ala Met Leu Asn Gln His Val Ile Asp Leu Ala Asp Ser Glu Met 
    130                 135                 140                 


Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu Asn Ala Glu 
145                 150                 155                 160 


Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys Asp Asp Asp 
                165                 170                 175     


Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Lys Tyr Arg 
            180                 185                 190         


Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp 
        195                 200             


<210>  11
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H7ssF_pylori (signal peptide-stabilised 
       HA stem from A/Anhui/1/2013 (H7N9)-SGG-H. pylori ferritin)

<400>  11

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Leu Val Phe Pro Gly Cys Gly Val Leu Lys Leu Ala Thr Gly Met 
    50                  55                  60                  


Lys Asn Val Pro Glu Ile Pro Lys Gly Arg Gly Leu Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr 
                85                  90                  95      


Gly Phe Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr 
            100                 105                 110         


Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg 
        115                 120                 125             


Val Ile Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu 
    130                 135                 140                 


Leu Leu Val Ala Met Leu Asn Gln His Val Ile Asp Leu Ala Asp Ser 
145                 150                 155                 160 


Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu Asn 
                165                 170                 175     


Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys Asp 
            180                 185                 190         


Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Lys 
        195                 200                 205             


Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Ser Gly Gly 
    210                 215                 220                 


Asp Ile Ile Lys Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser 
225                 230                 235                 240 


Ser Asn Leu Tyr Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu 
                245                 250                 255     


Asp Gly Ala Gly Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu 
            260                 265                 270         


His Ala Lys Lys Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val 
        275                 280                 285             


Gln Leu Thr Ser Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr 
    290                 295                 300                 


Gln Ile Phe Gln Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser 
305                 310                 315                 320 


Ile Asn Asn Ile Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr 
                325                 330                 335     


Phe Asn Phe Leu Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val 
            340                 345                 350         


Leu Phe Lys Asp Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn 
        355                 360                 365             


His Gly Leu Tyr Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser 
    370                 375                 380                 


Arg Lys Ser 
385         


<210>  12
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H1ssF_TM (signal peptide-stabilised HA 
       stem from A/Michigan/45/2015 (H1N1)-SGG-transmembrane element)

<400>  12

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Gly Ser Gly Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser 
    50                  55                  60                  


Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
65                  70                  75                  80  


Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
                85                  90                  95      


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala 
            100                 105                 110         


Ile Asp Lys Ile Thr Asn Met Val Asn Ser Val Ile Glu Lys Met Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Leu 
    130                 135                 140                 


Asn Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr 
145                 150                 155                 160 


Glu Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn 
                165                 170                 175     


Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser 
            180                 185                 190         


Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys 
        195                 200                 205             


Leu Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile 
    210                 215                 220                 


Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu 
225                 230                 235                 240 


Val Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser 
                245                 250                 255     


Leu Gln Cys Arg Ile Cys Ile 
            260             


<210>  13
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H3ssF_TM (signal peptide-stabilised HA 
       stem from A/Finland/486/2004 (H3N2)-SGG- transmembrane element)

<400>  13

Met Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Phe Pro Gly Cys Gly 
    50                  55                  60                  


Val Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
65                  70                  75                  80  


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
                85                  90                  95      


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
            100                 105                 110         


Ile Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln 
        115                 120                 125             


Ile Asn Gly Met Val Asn Arg Val Ile Glu Leu Met Glu Gln Gly Gly 
    130                 135                 140                 


Pro Asp Cys Tyr Leu Ala Glu Leu Leu Val Ala Leu Leu Asn Gln His 
145                 150                 155                 160 


Val Ile Asp Leu Thr Asp Ser Glu Met Arg Lys Leu Phe Glu Arg Thr 
                165                 170                 175     


Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe 
            180                 185                 190         


Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn 
        195                 200                 205             


Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg 
    210                 215                 220                 


Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile 
225                 230                 235                 240 


Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu 
                245                 250                 255     


Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn 
            260                 265                 270         


Ile Cys Ile 
        275 


<210>  14
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H10ssF_TM (signal peptide-stabilised HA 
       stem from A/Jiangxi/IPB13/2013 (H10N8)-SGG- transmembrane 
       element)

<400>  14

Met Tyr Lys Ile Val Val Ile Ile Ala Leu Leu Gly Ala Val Lys Gly 
1               5                   10                  15      


Leu Asp Lys Ile Cys Leu Gly His His Ala Val Ala Asn Gly Thr Ile 
            20                  25                  30          


Val Lys Thr Leu Thr Asn Glu Gln Glu Glu Val Thr Asn Ala Thr Glu 
        35                  40                  45              


Leu Val Phe Pro Gly Cys Gly Val Leu Met Leu Ala Thr Gly Met Arg 
    50                  55                  60                  


Asn Val Pro Glu Leu Ile Gln Gly Arg Gly Leu Phe Gly Ala Ile Ala 
65                  70                  75                  80  


Gly Phe Leu Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
                85                  90                  95      


Phe Arg His Gln Asn Ala Gln Gly Thr Gly Gln Ala Ala Asp Tyr Lys 
            100                 105                 110         


Ser Thr Gln Ala Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg Val 
        115                 120                 125             


Val Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu Leu 
    130                 135                 140                 


Leu Val Ala Met Leu Asn Gln His Val Ile Asp Met Ala Asp Ser Glu 
145                 150                 155                 160 


Met Arg Asn Leu Tyr Glu Arg Val Arg Lys Gln Leu Arg Gln Asn Ala 
                165                 170                 175     


Glu Glu Asp Gly Lys Gly Cys Phe Glu Ile Tyr His Ala Cys Asp Asp 
            180                 185                 190         


Ser Cys Met Glu Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Gln Tyr 
        195                 200                 205             


Arg Glu Glu Ala Leu Leu Asn Arg Leu Asn Ile Asn Pro Val Thr Leu 
    210                 215                 220                 


Ser Ser Gly Tyr Lys Asp Ile Ile Leu Trp Phe Ser Phe Gly Ala Ser 
225                 230                 235                 240 


Cys Phe Val Leu Leu Ala Val Val Met Gly Leu Phe Phe Phe Cys Leu 
                245                 250                 255     


Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
            260                 265         


<210>  15
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide sequence of H7ssF_TM (signal peptide-stabilised HA 
       stem from A/Anhui/1/2013 (H7N9)-SGG- transmembrane element)

<400>  15

Met Asn Thr Gln Ile Leu Val Phe Ala Leu Ile Ala Ile Ile Pro Thr 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr 
            20                  25                  30          


Lys Val Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr 
        35                  40                  45              


Glu Leu Val Phe Pro Gly Cys Gly Val Leu Lys Leu Ala Thr Gly Met 
    50                  55                  60                  


Lys Asn Val Pro Glu Ile Pro Lys Gly Arg Gly Leu Phe Gly Ala Ile 
65                  70                  75                  80  


Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr 
                85                  90                  95      


Gly Phe Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr 
            100                 105                 110         


Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Met Val Asn Arg 
        115                 120                 125             


Val Ile Glu Leu Met Glu Gln Gly Gly Pro Asp Cys Tyr Leu Ala Glu 
    130                 135                 140                 


Leu Leu Val Ala Met Leu Asn Gln His Val Ile Asp Leu Ala Asp Ser 
145                 150                 155                 160 


Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu Asn 
                165                 170                 175     


Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys Asp 
            180                 185                 190         


Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Lys 
        195                 200                 205             


Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro Val Lys 
    210                 215                 220                 


Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe Gly Ala 
225                 230                 235                 240 


Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe Ile Cys 
                245                 250                 255     


Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
            260                 265             


<210>  16
<211>  1418
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of unmodified nativeSP_H1ss_pylori from 
       A/Michigan/45/2015 (H1N1)

<400>  16
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aaggccaucc uggugguccu ccuguacacc uucaccacgg      120

ccaacgcgga cacccugugc aucggcuacc acgccaacaa cagcaccgac accguggaca      180

ccguccucga gaagaacgug accgugaccc acuccgucaa ccuggggagc ggccugcgcc      240

ucgccacggg gcugcggaac gugcccucca uccagagccg cggccuguuc ggggcgaucg      300

ccggcuucau cgagggcggg uggaccggca ugguggacgg gugguacggc uaccaccacc      360

agaacgagca gggguccggc uacgccgccg accucaagag cacccagaac gccaucgaca      420

agaucaccaa cauggucaac uccgugaucg agaagauggg cagcgggggc uccgggacgu      480

acaacgcgga gcugcuggug cuccugcuga acgagcggac ccucgacuac cacgacagca      540

acgucaagaa ccuguacgag aaggugcgca accagcugaa gaacaacgcc aaggagaucg      600

gcaacggcug cuucgaguuc uaccacaagu gcgacaacac gugcauggag uccgugaaga      660

acgggaccua cgacuacccg aaguacagcg aggaggccaa gcucaaccgg gagaagaucg      720

acagcggcgg ggacaucauc aagcuccuga acgagcaggu caacaaggag augcagucca      780

gcaaccugua cauguccaug agcuccuggu gcuacaccca cagccucgac ggcgccgggc      840

uguuccuguu cgaccacgcc gcggaggagu acgagcacgc caagaagcuc aucaucuucc      900

ugaacgagaa caacgugccc gugcagcuga ccuccaucag cgccccggag cacaaguucg      960

agggccucac gcagaucuuc cagaaggccu acgagcacga gcagcacauc uccgagagca     1020

ucaacaacau cguggaccac gccaucaagu ccaaggacca cgcgaccuuc aacuuccugc     1080

agugguacgu cgccgagcag cacgaggagg aggugcuguu caaggacauc cucgacaaga     1140

ucgagcugau cgggaacgag aaccacggcc uguaccucgc cgaccaguac gugaagggga     1200

ucgccaagag ccgcaagucc ugaggacuag ucccuguucc cagagcccac uuuuuuuucu     1260

uuuuuugaaa uaaaauagcc ugucuuucag aucucaaagg cucuuuucag agccaccaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                             1418


<210>  17
<211>  1424
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H1ss_pylori from A/Michigan/45/2015 (H1N1)

<400>  17
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aaggccaucc uggugguccu ccuguacacc uucaccacgg      120

ccaacgcgga cacccugugc aucggcuacc acgccaacaa cagcaccgac accguggaca      180

ccguccucga gaagaacgug accgugaccc acuccgucaa ccuggggagc ggccugcgcc      240

ucgccacggg gcugcggaac gugcccucca uccagagccg cggccuguuc ggggcgaucg      300

ccggcuucau cgagggcggg uggaccggca ugguggacgg gugguacggc uaccaccacc      360

agaacgagca gggguccggc uacgccgccg accucaagag cacccagaac gccaucgaca      420

agaucaccaa cauggucaac uccgugaucg agaagauggg cagcgggggc uccgggacgu      480

acaacgcgga gcugcuggug cuccugcuga acgagcggac ccucgacuac cacgacagca      540

acgucaagaa ccuguacgag aaggugcgca accagcugaa gaacaacgcc aaggagaucg      600

gcaacggcug cuucgaguuc uaccacaagu gcgacaacac gugcauggag uccgugaaga      660

acgggaccua cgacuacccg aaguacagcg aggaggccaa gcucaaccgg gagaagaucg      720

acagcggcgg ggacaucauc aagcuccuga acgagcaggu caacaaggag augcagucca      780

gcaaccugua cauguccaug agcuccuggu gcuacaccca cagccucgac ggcgccgggc      840

uguuccuguu cgaccacgcc gcggaggagu acgagcacgc caagaagcuc aucaucuucc      900

ugaacgagaa caacgugccc gugcagcuga ccuccaucag cgccccggag cacaaguucg      960

agggccucac gcagaucuuc cagaaggccu acgagcacga gcagcacauc uccgagagca     1020

ucaacaacau cguggaccac gccaucaagu ccaaggacca cgcgaccuuc aacuuccugc     1080

agugguacgu cgccgagcag cacgaggagg aggugcuguu caaggacauc cucgacaaga     1140

ucgagcugau cgggaacgag aaccacggcc uguaccucgc cgaccaguac gugaagggga     1200

ucgccaagag ccgcaagucc ugaugaugag gacuaguccc uguucccaga gcccacuuuu     1260

uuuucuuuuu uugaaauaaa auagccuguc uuucagaucu caaaggcucu uuucagagcc     1320

accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1424


<210>  18
<211>  1457
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of unmodified nativeSP_H3ss_pylori from 
       A/Finland/486/2004 (H3N2)

<400>  18
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aagaccauca ucgcccugag cuacauccuc ugccuggugu      120

ucgcccagaa gcugcccggc aacgacaaca gcaccgccac ccucugccug gggcaccacg      180

ccgugccaaa cggcacaauc gucaagacca ucaccaacga ccagaucgag gugaccaacg      240

caacagagcu gguguucccc gggugcggcg uccucaagcu ggccaccggg augaggaacg      300

ugcccgagaa gcagaccagg ggcaucuucg gcgccaucgc cggguucauc gagaacggcu      360

gggaggggau gguggacggc ugguacgggu ucaggcacca gaacuccgag ggcaucggcc      420

aggccgcaga ccucaagagc acccaggccg ccaucaacca gaucaacggg auggucaacc      480

gggugaucga gcugauggag cagggcgggc ccgacugcua ccuggccgag cugcucgugg      540

cacugcugaa ccagcacguc aucgaccuca cagacuccga gaugaggaag cuguucgagc      600

ggaccaagaa gcagcugagg gagaacgccg aggacauggg caacggcugc uucaagaucu      660

accacaagug cgacaacgcc ugcaucggga gcauccggaa cggcaccuac gaccacgacg      720

uguacaggga cgaggcccuc aacaaccggu uccagaucaa gagcggcggg gacaucauca      780

agcuccugaa cgagcagguc aacaaggaga ugcaguccag caaccuguac auguccauga      840

gcuccuggug cuacacccac agccucgacg gcgccgggcu guuccuguuc gaccacgccg      900

cggaggagua cgagcacgcc aagaagcuca ucaucuuccu gaacgagaac aacgugcccg      960

ugcagcugac cuccaucagc gccccggagc acaaguucga gggccucacg cagaucuucc     1020

agaaggccua cgagcacgag cagcacaucu ccgagagcau caacaacauc guggaccacg     1080

ccaucaaguc caaggaccac gcgaccuuca acuuccugca gugguacguc gccgagcagc     1140

acgaggagga ggugcuguuc aaggacaucc ucgacaagau cgagcugauc gggaacgaga     1200

accacggccu guaccucgcc gaccaguacg ugaaggggau cgccaagagc cgcaaguccu     1260

gaggacuagu cccuguuccc agagcccacu uuuuuuucuu uuuuugaaau aaaauagccu     1320

gucuuucaga ucucaaaggc ucuuuucaga gccaccaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaa                                                    1457


<210>  19
<211>  1463
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H3ss_pylori from A/Finland/486/2004 (H3N2)

<400>  19
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aagaccauca ucgcccugag cuacauccuc ugccuggugu      120

ucgcccagaa gcugcccggc aacgacaaca gcaccgccac ccucugccug gggcaccacg      180

ccgugccaaa cggcacaauc gucaagacca ucaccaacga ccagaucgag gugaccaacg      240

caacagagcu gguguucccc gggugcggcg uccucaagcu ggccaccggg augaggaacg      300

ugcccgagaa gcagaccagg ggcaucuucg gcgccaucgc cggguucauc gagaacggcu      360

gggaggggau gguggacggc ugguacgggu ucaggcacca gaacuccgag ggcaucggcc      420

aggccgcaga ccucaagagc acccaggccg ccaucaacca gaucaacggg auggucaacc      480

gggugaucga gcugauggag cagggcgggc ccgacugcua ccuggccgag cugcucgugg      540

cacugcugaa ccagcacguc aucgaccuca cagacuccga gaugaggaag cuguucgagc      600

ggaccaagaa gcagcugagg gagaacgccg aggacauggg caacggcugc uucaagaucu      660

accacaagug cgacaacgcc ugcaucggga gcauccggaa cggcaccuac gaccacgacg      720

uguacaggga cgaggcccuc aacaaccggu uccagaucaa gagcggcggg gacaucauca      780

agcuccugaa cgagcagguc aacaaggaga ugcaguccag caaccuguac auguccauga      840

gcuccuggug cuacacccac agccucgacg gcgccgggcu guuccuguuc gaccacgccg      900

cggaggagua cgagcacgcc aagaagcuca ucaucuuccu gaacgagaac aacgugcccg      960

ugcagcugac cuccaucagc gccccggagc acaaguucga gggccucacg cagaucuucc     1020

agaaggccua cgagcacgag cagcacaucu ccgagagcau caacaacauc guggaccacg     1080

ccaucaaguc caaggaccac gcgaccuuca acuuccugca gugguacguc gccgagcagc     1140

acgaggagga ggugcuguuc aaggacaucc ucgacaagau cgagcugauc gggaacgaga     1200

accacggccu guaccucgcc gaccaguacg ugaaggggau cgccaagagc cgcaaguccu     1260

gaugaugagg acuagucccu guucccagag cccacuuuuu uuucuuuuuu ugaaauaaaa     1320

uagccugucu uucagaucuc aaaggcucuu uucagagcca ccaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aaaaaaaaaa aaaaaaaaaa aaa                                             1463


<210>  20
<211>  1439
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H10ss_pylori from A/Jiangxi/IPB13/2013 (H10N8)

<400>  20
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uacaagaucg uggucaucau cgcccugcuc ggcgccguga      120

aggggcugga caagaucugc cucggccacc acgccguggc caacggaacc aucgucaaga      180

cccugacaaa cgagcaggag gaggugacca acgcaaccga gcugguguuc cccggcugcg      240

gaguccucau gcuggccacc ggcaugagga acgugccaga gcugauccag ggaaggggcc      300

ucuucggcgc caucgccgga uuccuggaga acggcuggga gggaauggug gacggcuggu      360

acggauucag gcaccagaac gcccagggca caggccaggc agccgacuac aagagcaccc      420

aggccgccau cgaccagauc accggaaugg ucaacagggu gguggagcug auggagcagg      480

gcgggcccga cugcuaccuc gcagagcugc uggucgccau gcucaaccag cacgugaucg      540

acauggccga cuccgagaug aggaaccugu acgagagggu gaggaagcag cugaggcaga      600

acgccgagga ggacggcaag ggcugcuucg agaucuacca cgccugcgac gacagcugca      660

uggaguccau caggaacaac accuacgacc acagccagua cagggaggag gcacuccuga      720

acaggcugaa caucaacagc ggcggggaca ucaucaagcu ccugaacgag caggucaaca      780

aggagaugca guccagcaac cuguacaugu ccaugagcuc cuggugcuac acccacagcc      840

ucgacggcgc cgggcuguuc cuguucgacc acgccgcgga ggaguacgag cacgccaaga      900

agcucaucau cuuccugaac gagaacaacg ugcccgugca gcugaccucc aucagcgccc      960

cggagcacaa guucgagggc cucacgcaga ucuuccagaa ggccuacgag cacgagcagc     1020

acaucuccga gagcaucaac aacaucgugg accacgccau caaguccaag gaccacgcga     1080

ccuucaacuu ccugcagugg uacgucgccg agcagcacga ggaggaggug cuguucaagg     1140

acauccucga caagaucgag cugaucggga acgagaacca cggccuguac cucgccgacc     1200

aguacgugaa ggggaucgcc aagagccgca aguccugaug augaggacua gucccuguuc     1260

ccagagccca cuuuuuuuuc uuuuuuugaa auaaaauagc cugucuuuca gaucucaaag     1320

gcucuuuuca gagccaccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1439


<210>  21
<211>  1442
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H7ss_pylori from A/Anhui/1/2013 (H7N9)

<400>  21
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aacacccaga uccugguguu cgcccucauc gccaucaucc      120

ccaccaacgc ggacaagauc ugccugggcc accacgccgu gagcaacgga accaagguca      180

acacccucac agagaggggc guggaggugg ucaacgccac cgagcuggug uuccccggau      240

gcggcgugcu gaagcucgca accggaauga agaacguccc agagaucccc aagggcaggg      300

gccuguucgg agccaucgcc ggcuucaucg agaacgggug ggagggccug aucgacgggu      360

gguacggcuu caggcaccag aacgcccagg gcgaggggac cgccgcagac uacaagucca      420

cacagagcgc caucgaccag aucaccggca uggugaacag ggugaucgag cucauggagc      480

agggcgggcc cgacugcuac cuggccgagc ugcucgucgc caugcugaac cagcacguga      540

ucgaccuggc agacuccgag auggacaagc ucuacgagag ggugaagagg cagcugaggg      600

agaacgccga ggaggacggc accgggugcu ucgagaucuu ccacaagugc gacgacgacu      660

gcauggccag caucaggaac aacaccuacg accacuccaa guacagggag gaggccaugc      720

agaacaggau ccagaucgac agcggcgggg acaucaucaa gcuccugaac gagcagguca      780

acaaggagau gcaguccagc aaccuguaca uguccaugag cuccuggugc uacacccaca      840

gccucgacgg cgccgggcug uuccuguucg accacgccgc ggaggaguac gagcacgcca      900

agaagcucau caucuuccug aacgagaaca acgugcccgu gcagcugacc uccaucagcg      960

ccccggagca caaguucgag ggccucacgc agaucuucca gaaggccuac gagcacgagc     1020

agcacaucuc cgagagcauc aacaacaucg uggaccacgc caucaagucc aaggaccacg     1080

cgaccuucaa cuuccugcag ugguacgucg ccgagcagca cgaggaggag gugcuguuca     1140

aggacauccu cgacaagauc gagcugaucg ggaacgagaa ccacggccug uaccucgccg     1200

accaguacgu gaaggggauc gccaagagcc gcaaguccug augaugagga cuagucccug     1260

uucccagagc ccacuuuuuu uucuuuuuuu gaaauaaaau agccugucuu ucagaucuca     1320

aaggcucuuu ucagagccac caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1440

aa                                                                    1442


<210>  22
<211>  1064
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of unmodified nativeSP_H1ss_TM from 
       A/Michigan/45/2015 (H1N1)

<400>  22
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aaggccaucc uggugguccu ccuguacacc uucaccacgg      120

ccaacgcgga cacccugugc aucggcuacc acgccaacaa cagcaccgac accguggaca      180

ccguccucga gaagaacgug accgugaccc acuccgucaa ccuggggagc ggccugcgcc      240

ucgccacggg gcugcggaac gugcccucca uccagagccg cggccuguuc ggggcgaucg      300

ccggcuucau cgagggcggg uggaccggca ugguggacgg gugguacggc uaccaccacc      360

agaacgagca gggguccggc uacgccgccg accucaagag cacccagaac gccaucgaca      420

agaucaccaa cauggucaac uccgugaucg agaagauggg cagcgggggc uccgggacgu      480

acaacgcgga gcugcuggug cuccugcuga acgagcggac ccucgacuac cacgacagca      540

acgucaagaa ccuguacgag aaggugcgca accagcugaa gaacaacgcc aaggagaucg      600

gcaacggcug cuucgaguuc uaccacaagu gcgacaacac gugcauggag uccgugaaga      660

acgggaccua cgacuacccg aaguacagcg aggaggccaa gcucaaccgg gagaagaucg      720

acggcgugaa gcucgagagc acccggaucu accagauccu ggccaucuac uccaccgucg      780

ccagcucccu ggugcucgug gucagccugg gggcgaucuc cuucuggaug ugcagcaacg      840

gcagccugca gugccgcauc ugcaucugag gacuaguccc uguucccaga gcccacuuuu      900

uuuucuuuuu uugaaauaaa auagccuguc uuucagaucu caaaggcucu uuucagagcc      960

accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1064


<210>  23
<211>  1070
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H1ss_TM from A/Michigan/45/2015 (H1N1)

<400>  23
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aaggccaucc uggugguccu ccuguacacc uucaccacgg      120

ccaacgcgga cacccugugc aucggcuacc acgccaacaa cagcaccgac accguggaca      180

ccguccucga gaagaacgug accgugaccc acuccgucaa ccuggggagc ggccugcgcc      240

ucgccacggg gcugcggaac gugcccucca uccagagccg cggccuguuc ggggcgaucg      300

ccggcuucau cgagggcggg uggaccggca ugguggacgg gugguacggc uaccaccacc      360

agaacgagca gggguccggc uacgccgccg accucaagag cacccagaac gccaucgaca      420

agaucaccaa cauggucaac uccgugaucg agaagauggg cagcgggggc uccgggacgu      480

acaacgcgga gcugcuggug cuccugcuga acgagcggac ccucgacuac cacgacagca      540

acgucaagaa ccuguacgag aaggugcgca accagcugaa gaacaacgcc aaggagaucg      600

gcaacggcug cuucgaguuc uaccacaagu gcgacaacac gugcauggag uccgugaaga      660

acgggaccua cgacuacccg aaguacagcg aggaggccaa gcucaaccgg gagaagaucg      720

acggcgugaa gcucgagagc acccggaucu accagauccu ggccaucuac uccaccgucg      780

ccagcucccu ggugcucgug gucagccugg gggcgaucuc cuucuggaug ugcagcaacg      840

gcagccugca gugccgcauc ugcaucugau gaugaggacu agucccuguu cccagagccc      900

acuuuuuuuu cuuuuuuuga aauaaaauag ccugucuuuc agaucucaaa ggcucuuuuc      960

agagccacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                1070


<210>  24
<211>  1100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of unmodified nativeSP_H3ss_TM from 
       A/Finland/486/2004 (H3N2)

<400>  24
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aagaccauca ucgcccugag cuacauccuc ugccuggugu      120

ucgcccagaa gcugcccggc aacgacaaca gcaccgccac ccucugccug gggcaccacg      180

ccgugccaaa cggcacaauc gucaagacca ucaccaacga ccagaucgag gugaccaacg      240

caacagagcu gguguucccc gggugcggcg uccucaagcu ggccaccggg augaggaacg      300

ugcccgagaa gcagaccagg ggcaucuucg gcgccaucgc cggguucauc gagaacggcu      360

gggaggggau gguggacggc ugguacgggu ucaggcacca gaacuccgag ggcaucggcc      420

aggccgcaga ccucaagagc acccaggccg ccaucaacca gaucaacggg auggucaacc      480

gggugaucga gcugauggag cagggcgggc ccgacugcua ccuggccgag cugcucgugg      540

cacugcugaa ccagcacguc aucgaccuca cagacuccga gaugaggaag cuguucgagc      600

ggaccaagaa gcagcugagg gagaacgccg aggacauggg caacggcugc uucaagaucu      660

accacaagug cgacaacgcc ugcaucggga gcauccggaa cggcaccuac gaccacgacg      720

uguacaggga cgaggcccuc aacaaccggu uccagaucaa gggcgucgag cucaagagcg      780

gcuacaagga cuggauccug uggaucuccu ucgcgaucag cugcuuccug cugugcgugg      840

cccugcucgg guucaucaug ugggccugcc agaagggcaa cauccggugc aacaucugca      900

ucugaggacu agucccuguu cccagagccc acuuuuuuuu cuuuuuuuga aauaaaauag      960

ccugucuuuc agaucucaaa ggcucuuuuc agagccacca aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa                                                 1100


<210>  25
<211>  1106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H3ss_TM from A/Finland/486/2004 (H3N2)

<400>  25
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aagaccauca ucgcccugag cuacauccuc ugccuggugu      120

ucgcccagaa gcugcccggc aacgacaaca gcaccgccac ccucugccug gggcaccacg      180

ccgugccaaa cggcacaauc gucaagacca ucaccaacga ccagaucgag gugaccaacg      240

caacagagcu gguguucccc gggugcggcg uccucaagcu ggccaccggg augaggaacg      300

ugcccgagaa gcagaccagg ggcaucuucg gcgccaucgc cggguucauc gagaacggcu      360

gggaggggau gguggacggc ugguacgggu ucaggcacca gaacuccgag ggcaucggcc      420

aggccgcaga ccucaagagc acccaggccg ccaucaacca gaucaacggg auggucaacc      480

gggugaucga gcugauggag cagggcgggc ccgacugcua ccuggccgag cugcucgugg      540

cacugcugaa ccagcacguc aucgaccuca cagacuccga gaugaggaag cuguucgagc      600

ggaccaagaa gcagcugagg gagaacgccg aggacauggg caacggcugc uucaagaucu      660

accacaagug cgacaacgcc ugcaucggga gcauccggaa cggcaccuac gaccacgacg      720

uguacaggga cgaggcccuc aacaaccggu uccagaucaa gggcgucgag cucaagagcg      780

gcuacaagga cuggauccug uggaucuccu ucgcgaucag cugcuuccug cugugcgugg      840

cccugcucgg guucaucaug ugggccugcc agaagggcaa cauccggugc aacaucugca      900

ucugaugaug aggacuaguc ccuguuccca gagcccacuu uuuuuucuuu uuuugaaaua      960

aaauagccug ucuuucagau cucaaaggcu cuuuucagag ccaccaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          1106


<210>  26
<211>  1076
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of unmodified nativeSP_H10ss_TM from 
       A/Jiangxi/IPB13/2013 (H10N8)

<400>  26
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uacaagaucg uggucaucau cgcccugcuc ggcgccguga      120

aggggcugga caagaucugc cucggccacc acgccguggc caacggaacc aucgucaaga      180

cccugacaaa cgagcaggag gaggugacca acgcaaccga gcugguguuc cccggcugcg      240

gaguccucau gcuggccacc ggcaugagga acgugccaga gcugauccag ggaaggggcc      300

ucuucggcgc caucgccgga uuccuggaga acggcuggga gggaauggug gacggcuggu      360

acggauucag gcaccagaac gcccagggca caggccaggc agccgacuac aagagcaccc      420

aggccgccau cgaccagauc accggaaugg ucaacagggu gguggagcug auggagcagg      480

gcgggcccga cugcuaccuc gcagagcugc uggucgccau gcucaaccag cacgugaucg      540

acauggccga cuccgagaug aggaaccugu acgagagggu gaggaagcag cugaggcaga      600

acgccgagga ggacggcaag ggcugcuucg agaucuacca cgccugcgac gacagcugca      660

uggaguccau caggaacaac accuacgacc acagccagua cagggaggag gcacuccuga      720

acaggcugaa caucaacccc gucacgcugu ccagcggcua caaggacauc auccuguggu      780

ucuccuucgg ggcgagcugc uucgugcucc uggccgucgu gaugggccug uucuucuucu      840

gccucaagaa cggcaacaug cgcugcacca ucugcaucug aggacuaguc ccuguuccca      900

gagcccacuu uuuuuucuuu uuuugaaaua aaauagccug ucuuucagau cucaaaggcu      960

cuuuucagag ccaccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         1076


<210>  27
<211>  1082
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H10ss_TM from A/Jiangxi/IPB13/2013 (H10N8)

<400>  27
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug uacaagaucg uggucaucau cgcccugcuc ggcgccguga      120

aggggcugga caagaucugc cucggccacc acgccguggc caacggaacc aucgucaaga      180

cccugacaaa cgagcaggag gaggugacca acgcaaccga gcugguguuc cccggcugcg      240

gaguccucau gcuggccacc ggcaugagga acgugccaga gcugauccag ggaaggggcc      300

ucuucggcgc caucgccgga uuccuggaga acggcuggga gggaauggug gacggcuggu      360

acggauucag gcaccagaac gcccagggca caggccaggc agccgacuac aagagcaccc      420

aggccgccau cgaccagauc accggaaugg ucaacagggu gguggagcug auggagcagg      480

gcgggcccga cugcuaccuc gcagagcugc uggucgccau gcucaaccag cacgugaucg      540

acauggccga cuccgagaug aggaaccugu acgagagggu gaggaagcag cugaggcaga      600

acgccgagga ggacggcaag ggcugcuucg agaucuacca cgccugcgac gacagcugca      660

uggaguccau caggaacaac accuacgacc acagccagua cagggaggag gcacuccuga      720

acaggcugaa caucaacccc gucacgcugu ccagcggcua caaggacauc auccuguggu      780

ucuccuucgg ggcgagcugc uucgugcucc uggccgucgu gaugggccug uucuucuucu      840

gccucaagaa cggcaacaug cgcugcacca ucugcaucug augaugagga cuagucccug      900

uucccagagc ccacuuuuuu uucuuuuuuu gaaauaaaau agccugucuu ucagaucuca      960

aaggcucuuu ucagagccac caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aa                                                                    1082


<210>  28
<211>  1079
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of unmodified nativeSP_H7ss_TM from 
       A/Anhui/1/2013 (H7N9)

<400>  28
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aacacccaga uccugguguu cgcccucauc gccaucaucc      120

ccaccaacgc ggacaagauc ugccugggcc accacgccgu gagcaacgga accaagguca      180

acacccucac agagaggggc guggaggugg ucaacgccac cgagcuggug uuccccggau      240

gcggcgugcu gaagcucgca accggaauga agaacguccc agagaucccc aagggcaggg      300

gccuguucgg agccaucgcc ggcuucaucg agaacgggug ggagggccug aucgacgggu      360

gguacggcuu caggcaccag aacgcccagg gcgaggggac cgccgcagac uacaagucca      420

cacagagcgc caucgaccag aucaccggca uggugaacag ggugaucgag cucauggagc      480

agggcgggcc cgacugcuac cuggccgagc ugcucgucgc caugcugaac cagcacguga      540

ucgaccuggc agacuccgag auggacaagc ucuacgagag ggugaagagg cagcugaggg      600

agaacgccga ggaggacggc accgggugcu ucgagaucuu ccacaagugc gacgacgacu      660

gcauggccag caucaggaac aacaccuacg accacuccaa guacagggag gaggccaugc      720

agaacaggau ccagaucgac cccgugaagc ugagcuccgg cuacaaggac gucauccucu      780

gguucagcuu cggggccucc ugcuucaucc ugcuggccau cgugaugggc cucguguuca      840

ucugcgucaa gaacgggaac augcgcugca ccaucugcau cugaggacua gucccuguuc      900

ccagagccca cuuuuuuuuc uuuuuuugaa auaaaauagc cugucuuuca gaucucaaag      960

gcucuuuuca gagccaccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa      1079


<210>  29
<211>  1085
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of N1-methylpseudouridine modified 
       nativeSP_H7ss_TM from A/Anhui/1/2013 (H7N9)

<400>  29
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug aacacccaga uccugguguu cgcccucauc gccaucaucc      120

ccaccaacgc ggacaagauc ugccugggcc accacgccgu gagcaacgga accaagguca      180

acacccucac agagaggggc guggaggugg ucaacgccac cgagcuggug uuccccggau      240

gcggcgugcu gaagcucgca accggaauga agaacguccc agagaucccc aagggcaggg      300

gccuguucgg agccaucgcc ggcuucaucg agaacgggug ggagggccug aucgacgggu      360

gguacggcuu caggcaccag aacgcccagg gcgaggggac cgccgcagac uacaagucca      420

cacagagcgc caucgaccag aucaccggca uggugaacag ggugaucgag cucauggagc      480

agggcgggcc cgacugcuac cuggccgagc ugcucgucgc caugcugaac cagcacguga      540

ucgaccuggc agacuccgag auggacaagc ucuacgagag ggugaagagg cagcugaggg      600

agaacgccga ggaggacggc accgggugcu ucgagaucuu ccacaagugc gacgacgacu      660

gcauggccag caucaggaac aacaccuacg accacuccaa guacagggag gaggccaugc      720

agaacaggau ccagaucgac cccgugaagc ugagcuccgg cuacaaggac gucauccucu      780

gguucagcuu cggggccucc ugcuucaucc ugcuggccau cgugaugggc cucguguuca      840

ucugcgucaa gaacgggaac augcgcugca ccaucugcau cugaugauga ggacuagucc      900

cuguucccag agcccacuuu uuuuucuuuu uuugaaauaa aauagccugu cuuucagauc      960

ucaaaggcuc uuuucagagc caccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1080

aaaaa                                                                 1085


